Patents by Inventor Yingzhi Bi

Yingzhi Bi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20110251204
    Abstract: The present disclosure is generally directed to compounds which can modulate G-protein coupled receptor 88, compositions comprising such compounds, and methods for modulating G-protein coupled receptor 88.
    Type: Application
    Filed: October 4, 2010
    Publication date: October 13, 2011
    Inventors: Yingzhi Bi, Carolyn Diane Dzierba, Joanne J. Bronson, Cynthia Fink, Michael Green, David Kimball, John E. Macor, Soojin Kwon, Yulian Zhang, Greg Zipp
  • Publication number: 20110245264
    Abstract: The present disclosure is generally directed to compounds which can modulate G-protein coupled receptor 88, compositions comprising such compounds, and methods for modulating G-protein coupled receptor 88.
    Type: Application
    Filed: October 1, 2010
    Publication date: October 6, 2011
    Inventors: Yingzhi Bi, Carolyn Diane Dzierba, Joanne J. Bronson, Kenneth Carson, Giovanni Cianchetta, Li Dong, Cynthia Fink, Michael Green, David Kimball, John E. Macor, Soojin Kwon, Jiancheng Wang, Yulian Zhang, Greg Zipp
  • Patent number: 7989640
    Abstract: Compounds are provided which are useful in the treatment of androgen receptor-associated conditions, such as age-related diseases, which compounds have the structure wherein R1, R2 and R4, are as defined herein; G is an aryl, heterocyclo or heteroaryl group, wherein said group is mono- or polycyclic, and which is optionally substituted; n is an integer of 1 or 2; m is an integer of 1 or 2; Z is oxygen (—O—) or NR4h; a prodrug ester, all stereoisomers thereof and a pharmaceutically acceptable salt thereof. A method for treating androgen receptor-associated conditions such as age-related diseases is also provided.
    Type: Grant
    Filed: September 13, 2010
    Date of Patent: August 2, 2011
    Assignee: Bristol-Myers Squibb Company
    Inventors: Lawrence G. Hamann, Yingzhi Bi, Mark C. Manfredi, Alexandra A. Nirschl, James C. Sutton
  • Publication number: 20110015408
    Abstract: Compounds are provided which are useful in the treatment of androgen receptor-associated conditions, such as age-related diseases, which compounds have the structure wherein R1, R2 and R4, are as defined herein; G is an aryl, heterocyclo or heteroaryl group, wherein said group is mono- or polycyclic, and which is optionally substituted; n is an integer of 1 or 2; m is an integer of 1 or 2; Z is oxygen (—O—) or NR4h; a prodrug ester, all stereoisomers thereof and a pharmaceutically acceptable salt thereof. A method for treating androgen receptor-associated conditions such as age-related diseases is also provided.
    Type: Application
    Filed: September 13, 2010
    Publication date: January 20, 2011
    Inventors: Lawrence G. Hamann, Yingzhi Bi, Mark C. Manfredi, Alexandra A. Nirschl, James C. Sutton
  • Patent number: 7820702
    Abstract: Compounds are provided which are useful in the treatment of androgen receptor-associated conditions, such as age-related diseases, which compounds have the structure wherein R1, R2, R3, R4, R4a, R4b, R4c, R4c1, Rd, Re, Rf, Rg, Rh, R5, R5?, R7, and R7? are defined herein; G is aryl, heterocycle or heteroaryl group, wherein said group is mono- or polycyclic, and which is optionally substituted; and n is an integer of 1 or 2, m is an integer of 1 or 2, Z is oxygen (—O—) or NR4b, a prodrug ester, all stereoisomers thereof and a pharmaceutically acceptable salt thereof. A method for treating androgen receptor-associated conditions such as age-related diseases is also provided.
    Type: Grant
    Filed: February 1, 2005
    Date of Patent: October 26, 2010
    Assignee: Bristol-Myers Squibb Company
    Inventors: Lawrence G. Hamann, Yingzhi Bi, Mark C. Manfredi, Alexandra A. Nirschl, James C. Sutton
  • Patent number: 7772267
    Abstract: There are provided compounds according to formula I wherein the substitutents are as described herein. Further provided are methods of using such compounds for the treatment of nuclear hormone receptor-associated conditions, such as age related diseases, for example sarcopenia. Also provided are pharmaceutical compositions containing such compounds and processes for preparing some of the compounds of the invention. Other embodiments are also disclosed.
    Type: Grant
    Filed: October 31, 2007
    Date of Patent: August 10, 2010
    Assignee: Bristol-Myers Squibb Company
    Inventors: Chong-qing Sun, Lawrence Hamann, David Augeri, Yingzhi Bi, Jeffrey Robl, Yan-Ting Huang, Tammy Wang, Alexandra Holubec, Ligaya Simpkins, James C. Sutton, James J. Li
  • Publication number: 20090286820
    Abstract: Multicyclic compounds, pharmaceutical compositions comprising them, and methods of their use are described.
    Type: Application
    Filed: May 19, 2009
    Publication date: November 19, 2009
    Inventors: Joseph Barbosa, Yingzhi Bi, Cynthia Anne Fink, Michael Alan Green, Jian Cheng Wang
  • Publication number: 20090181992
    Abstract: Multicyclic compounds and pharmaceutical compositions comprising them are described, along with methods of their use in the treatment of diseases such as age-associated memory impairment, Alzheimer's disease, Attention-Deficit/Hyperactivity Disorder (ADD/ADHD), autism, Down syndrome, Fragile X syndrome, Huntington's disease, Parkinson's disease, and schizophrenia.
    Type: Application
    Filed: March 24, 2009
    Publication date: July 16, 2009
    Inventors: Joseph Barbosa, Yingzhi Bi, Cynthia Anne Fink, Michael Alan Green, Jian Cheng Wang
  • Patent number: 7405234
    Abstract: The invention provides compounds according to formula I wherein the substitutents are as described herein. Further provided are methods of using such compounds for the treatment of nuclear hormone receptor-associated conditions, such as age related diseases, for example sarcopenia. Also provided are pharmaceutical compositions containing such compounds and processes for preparing some of the compounds of the invention.
    Type: Grant
    Filed: February 17, 2004
    Date of Patent: July 29, 2008
    Assignee: Bristol-Myers Squibb Company
    Inventors: Chong-Qing Sun, Lawrence Hamann, David Augeri, Yingzhi Bi, Jeffrey Robl, Yan-Ting Huang, Tammy Wang, Alexandra Holubec, Ligaya Simpkins, James C. Sutton, James J. Li
  • Publication number: 20080146596
    Abstract: Multicyclic compounds, pharmaceutical compositions comprising them, and methods of their use are described.
    Type: Application
    Filed: November 5, 2007
    Publication date: June 19, 2008
    Inventors: Joseph Barbosa, Yingzhi Bi, Cynthia Anne Fink, Michael Alan Green, Jian Cheng Wang
  • Publication number: 20080146600
    Abstract: Multicyclic compounds, pharmaceutical compositions comprising them, and methods of their use are described.
    Type: Application
    Filed: November 5, 2007
    Publication date: June 19, 2008
    Inventors: Joseph Barbosa, Yingzhi Bi, Cynthia Anne Fink, Michael Alan Green, Jian Cheng Wang
  • Patent number: 7388027
    Abstract: The present invention relates to bicyclic compounds according to formula I, pharmaceutical compositions containing such compounds and methods of using such compounds in the treatment of androgen receptor-associated conditions, such as age-related diseases, for example sarcopenia, wherein R1, R2, R2? R5, G, n and W are defined herein.
    Type: Grant
    Filed: March 2, 2005
    Date of Patent: June 17, 2008
    Assignee: Bristol-Myers Squibb Company
    Inventors: James J. Li, Lawrence Hamann, David Augeri, Yingzhi Bi
  • Publication number: 20080139598
    Abstract: This invention relates to multicyclic compounds, pharmaceutical compositions comprising them, and methods of their use.
    Type: Application
    Filed: November 5, 2007
    Publication date: June 12, 2008
    Inventors: Joseph Barbosa, Yingzhi Bi, Cynthia Anne Fink, Jian Cheng Wang
  • Patent number: 7384958
    Abstract: Compounds of the formula (I) are useful as inhibitors of cGMP PDE especially Type 5.
    Type: Grant
    Filed: March 1, 2007
    Date of Patent: June 10, 2008
    Assignee: Bristol-Myers Squibb Company
    Inventors: Yingzhi Bi, Guixue Yu, David P. Rotella, John E. Macor
  • Patent number: 7378430
    Abstract: Compounds of the formula (I) are useful as inhibitors of cGMP PDE especially Type 5.
    Type: Grant
    Filed: December 18, 2006
    Date of Patent: May 27, 2008
    Assignee: Bristol-Myers Squibb Company
    Inventors: Yingzhi Bi, Guixue Yu, David P. Rotella, John E. Macor
  • Publication number: 20080108649
    Abstract: There are provided compounds according to formula I wherein the substitutents are as described herein. Further provided are methods of using such compounds for the treatment of nuclear hormone receptor-associated conditions, such as age related diseases, for example sarcopenia. Also provided are pharmaceutical compositions containing such compounds and processes for preparing some of the compounds of the invention. Other embodiments are also disclosed.
    Type: Application
    Filed: October 31, 2007
    Publication date: May 8, 2008
    Applicant: BRISTOL-MYERS SQUIBB COMPANY
    Inventors: Chong-Qing Sun, Lawrence Hamann, David Augeri, Yingzhi Bi, Jeffrey Robl, Yan-Ting Huang, Tammy Wang, Alexandra Holubec, Ligaya Simpkins, James Sutton, James Li
  • Publication number: 20080103188
    Abstract: There are provided bicyclic compounds according to formula I, pharmaceutical compositions containing such compounds and methods of using such compounds in the treatment of androgen receptor-associated conditions, such as age-related diseases, for example sarcopenia, wherein R1, R2, R2?, R5, G, n and W are defined herein. Other embodiments are also provided.
    Type: Application
    Filed: October 31, 2007
    Publication date: May 1, 2008
    Applicant: BRISTOL-MYERS SQUIBB COMPANY
    Inventors: James LI, Lawrence HAMMANN, David AUGERI, Yingzhi BI
  • Patent number: 7256208
    Abstract: The present invention relates to novel compounds useful in the treatment of androgen receptor associated conditions, such as age-related diseases, pharmaceutical compositions containing at least one of the compounds of the present invention and methods of treating a patient in need of therapy for an androgen receptor associated condition by administering a therapeutically effective amount of at least compound of the present invention.
    Type: Grant
    Filed: November 9, 2004
    Date of Patent: August 14, 2007
    Assignee: Bristol-Myers Squibb Company
    Inventors: Yingzhi Bi, Lawrence G. Hamann, Mark C. Manfredi, Ligaya M. Simpkins
  • Publication number: 20070155788
    Abstract: Compounds of the formula (I) are useful as inhibitors of cGMP PDE especially Type 5.
    Type: Application
    Filed: March 1, 2007
    Publication date: July 5, 2007
    Inventors: Yingzhi Bi, Guixue Yu, David Rotella, John Macor
  • Publication number: 20070155775
    Abstract: Compounds of the formula (I) are useful as inhibitors of cGMP PDE especially Type 5.
    Type: Application
    Filed: March 1, 2007
    Publication date: July 5, 2007
    Inventors: Yingzhi Bi, Guixue Yu, David Rotella, John Macor