Patents by Inventor Yingzhi Bi

Yingzhi Bi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PYRAZOLO[1,5-a]PYRIMIDINE-BASED COMPOUNDS, COMPOSITIONS COMPRISING THEM, AND METHODS OF THEIR USE
    Publication number: 20150175610
    Abstract: Pyrazolo[1,5-a]pyrimidine-based compounds of the formula: are disclosed, wherein R1, R2 and R3 are defined herein. Compositions comprising the compounds and methods of their use to treat, manage and/or prevent diseases and disorders mediated by mediated by adaptor associated kinase 1 activity are also disclosed.
    Type: Application
    Filed: September 5, 2014
    Publication date: June 25, 2015
    Inventors: Yingzhi BI, Michael Walter GARDYAN, Michael Alan GREEN, Godwin KUMI, Yulian ZHANG
  • Imidazo[1,2-b]pyridazine-based compounds, compositions comprising them, and methods of their use
    Patent number: 8969565
    Abstract: Imidazo[1,2-b]pyridazine-based compounds of the formula: are disclosed, wherein R1, R2 and R3 are defined herein. Compositions comprising the compounds and methods of their use to treat, manage and/or prevent diseases and disorders mediated by mediated by adaptor associated kinase 1 activity are also disclosed.
    Type: Grant
    Filed: March 5, 2013
    Date of Patent: March 3, 2015
    Assignee: Lexicon Pharmaceuticals, Inc.
    Inventors: Yingzhi Bi, Kenneth Gordon Carson, Giovanni Cianchetta, Michael Alan Green, Godwin Kumi, Zhi Liang, Ying Jade Liu, Alan Main, Yulian Zhang, Gregory Glenn Zipp
  • Pyrazolo[1,5-a]pyrimidine-based compounds, compositions comprising them, and methods of their use
    Patent number: 8946415
    Abstract: Pyrazolo[1,5-a]pyrimidine-based compounds of the formula: are disclosed, wherein R1, R2 and R3 are defined herein. Compositions comprising the compounds and methods of their use to treat, manage and/or prevent diseases and disorders mediated by adaptor associated kinase 1 activity are also disclosed.
    Type: Grant
    Filed: March 5, 2013
    Date of Patent: February 3, 2015
    Assignee: Lexicon Pharmaceuticals, Inc.
    Inventors: Yingzhi Bi, Kenneth Gordon Carson, Giovanni Cianchetta, Michael Alan Green, Godwin Kumi, Alan Main, Yulian Zhang, Gregory Glenn Zipp
  • PYRAZOLO[1,5-a]PYRIMIDINE-BASED COMPOUNDS, COMPOSITIONS COMPRISING THEM, AND METHODS OF THEIR USE
    Publication number: 20130253194
    Abstract: Pyrazolo[1,5-a]pyrimidine-based compounds of the formula: are disclosed, wherein R1, R2 and R3 are defined herein. Compositions comprising the compounds and methods of their use to treat, manage and/or prevent diseases and disorders mediated by mediated by adaptor associated kinase 1 activity are also disclosed.
    Type: Application
    Filed: March 5, 2013
    Publication date: September 26, 2013
    Inventors: Yingzhi BI, Kenneth Gordon CARSON, Giovanni CIANCHETTA, Michael Alan GREEN, Godwin KUMI, Alan MAIN, Yulian ZHANG, Gregory Glenn ZIPP
  • IMIDAZO[1,2-b]PYRIDAZINE-BASED COMPOUNDS, COMPOSITIONS COMPRISING THEM, AND METHODS OF THEIR USE
    Publication number: 20130245021
    Abstract: Imidazo[1,2-b]pyridazine-based compounds of the formula: are disclosed, wherein R1, R2 and R3 are defined herein. Compositions comprising the compounds and methods of their use to treat, manage and/or prevent diseases and disorders mediated by mediated by adaptor associated kinase 1 activity are also disclosed.
    Type: Application
    Filed: March 5, 2013
    Publication date: September 19, 2013
    Inventors: Yingzhi BI, Kenneth Gordon CARSON, Giovanni CIANCHETTA, Michael Alan GREEN, Godwin KUMI, Zhi LIANG, Ying Jade LIU, Alan MAIN, Yulian ZHANG, Gregory Glenn ZIPP
  • Modulators of G protein-coupled receptor 88
    Patent number: 8497271
    Abstract: The present disclosure is generally directed to compounds which can modulate G-protein coupled receptor 88, compositions comprising such compounds, and methods for modulating G-protein coupled receptor 88.
    Type: Grant
    Filed: October 1, 2010
    Date of Patent: July 30, 2013
    Assignees: Bristol-Myers Squibb Company, Lexicon Pharmaceuticals, Inc.
    Inventors: Yingzhi Bi, Carolyn Diane Dzierba, Joanne J. Bronson, Kenneth Carson, Giovanni Cianchetta, Li Dong, Cynthia Fink, Michael Green, David Kimball, John E. Macor, Soojin Kwon, Jiancheng Wang, Yulian Zhang, Greg Zipp
  • Modulators of G protein-coupled receptor 88
    Patent number: 8426414
    Abstract: The present disclosure is generally directed to compounds which can modulate G-protein coupled receptor 88, compositions comprising such compounds, and methods for modulating G-protein coupled receptor 88.
    Type: Grant
    Filed: October 4, 2010
    Date of Patent: April 23, 2013
    Assignees: Bristol-Myers Squibb Company, Lexicon Pharmaceuticals, Inc.
    Inventors: Yingzhi Bi, Carolyn Diane Dzierba, Joanne J. Bronson, Cynthia Fink, Michael Green, David Kimball, John E. Macor, Soojin Kwon, Yulian Zhang, Greg Zipp
  • Modulators of G protein-coupled receptor 88
    Patent number: 8304577
    Abstract: The present disclosure is generally directed to compounds which can modulate G-protein coupled receptor 88, compositions comprising such compounds, and methods for modulating G-protein coupled receptor 88.
    Type: Grant
    Filed: October 5, 2010
    Date of Patent: November 6, 2012
    Assignees: Bristol-Myers Squibb Company, Lexicon Pharmaceuticals, Inc.
    Inventors: Carolyn Diane Dzierba, Richard A. Hartz, Yingzhi Bi, Vijay T. Ahuja, Joanne J. Bronson, Kenneth Carson, Giovanni Cianchetta, Michael Green, David Kimball, S. Roy Kimura, Soojin Kwon, John E. Macor, Yulian Zhang, Greg Zipp
  • Modulators of G Protein-Coupled Receptor 88
    Publication number: 20110251204
    Abstract: The present disclosure is generally directed to compounds which can modulate G-protein coupled receptor 88, compositions comprising such compounds, and methods for modulating G-protein coupled receptor 88.
    Type: Application
    Filed: October 4, 2010
    Publication date: October 13, 2011
    Inventors: Yingzhi Bi, Carolyn Diane Dzierba, Joanne J. Bronson, Cynthia Fink, Michael Green, David Kimball, John E. Macor, Soojin Kwon, Yulian Zhang, Greg Zipp
  • Modulators of G Protein-Coupled Receptor 88
    Publication number: 20110251196
    Abstract: The present disclosure is generally directed to compounds which can modulate G-protein coupled receptor 88, compositions comprising such compounds, and methods for modulating G-protein coupled receptor 88.
    Type: Application
    Filed: October 5, 2010
    Publication date: October 13, 2011
    Inventors: Carolyn Diane Dzierba, Richard A. Hartz, Yingzhi Bi, Vijay T. Ahuja, Joanne J. Bronson, Kenneth Carson, Giovanni Cianchetta, Michael Green, David Kimball, S. Roy Kimura, Soojin Kwon, John E. Macor, Yulian Zhang, Greg Zipp
  • Modulators of G Protein-Coupled Receptor 88
    Publication number: 20110245264
    Abstract: The present disclosure is generally directed to compounds which can modulate G-protein coupled receptor 88, compositions comprising such compounds, and methods for modulating G-protein coupled receptor 88.
    Type: Application
    Filed: October 1, 2010
    Publication date: October 6, 2011
    Inventors: Yingzhi Bi, Carolyn Diane Dzierba, Joanne J. Bronson, Kenneth Carson, Giovanni Cianchetta, Li Dong, Cynthia Fink, Michael Green, David Kimball, John E. Macor, Soojin Kwon, Jiancheng Wang, Yulian Zhang, Greg Zipp
  • Sulfonylpyrrolidine modulators of androgen receptor function and method
    Patent number: 7989640
    Abstract: Compounds are provided which are useful in the treatment of androgen receptor-associated conditions, such as age-related diseases, which compounds have the structure wherein R1, R2 and R4, are as defined herein; G is an aryl, heterocyclo or heteroaryl group, wherein said group is mono- or polycyclic, and which is optionally substituted; n is an integer of 1 or 2; m is an integer of 1 or 2; Z is oxygen (—O—) or NR4h; a prodrug ester, all stereoisomers thereof and a pharmaceutically acceptable salt thereof. A method for treating androgen receptor-associated conditions such as age-related diseases is also provided.
    Type: Grant
    Filed: September 13, 2010
    Date of Patent: August 2, 2011
    Assignee: Bristol-Myers Squibb Company
    Inventors: Lawrence G. Hamann, Yingzhi Bi, Mark C. Manfredi, Alexandra A. Nirschl, James C. Sutton
  • SULFONYLPYRROLIDINE MODULATORS OF ANDROGEN RECEPTOR FUNCTION AND METHOD
    Publication number: 20110015408
    Abstract: Compounds are provided which are useful in the treatment of androgen receptor-associated conditions, such as age-related diseases, which compounds have the structure wherein R1, R2 and R4, are as defined herein; G is an aryl, heterocyclo or heteroaryl group, wherein said group is mono- or polycyclic, and which is optionally substituted; n is an integer of 1 or 2; m is an integer of 1 or 2; Z is oxygen (—O—) or NR4h; a prodrug ester, all stereoisomers thereof and a pharmaceutically acceptable salt thereof. A method for treating androgen receptor-associated conditions such as age-related diseases is also provided.
    Type: Application
    Filed: September 13, 2010
    Publication date: January 20, 2011
    Inventors: Lawrence G. Hamann, Yingzhi Bi, Mark C. Manfredi, Alexandra A. Nirschl, James C. Sutton
  • Sulfonylpyrrolidine modulators of androgen receptor function and method
    Patent number: 7820702
    Abstract: Compounds are provided which are useful in the treatment of androgen receptor-associated conditions, such as age-related diseases, which compounds have the structure wherein R1, R2, R3, R4, R4a, R4b, R4c, R4c1, Rd, Re, Rf, Rg, Rh, R5, R5?, R7, and R7? are defined herein; G is aryl, heterocycle or heteroaryl group, wherein said group is mono- or polycyclic, and which is optionally substituted; and n is an integer of 1 or 2, m is an integer of 1 or 2, Z is oxygen (—O—) or NR4b, a prodrug ester, all stereoisomers thereof and a pharmaceutically acceptable salt thereof. A method for treating androgen receptor-associated conditions such as age-related diseases is also provided.
    Type: Grant
    Filed: February 1, 2005
    Date of Patent: October 26, 2010
    Assignee: Bristol-Myers Squibb Company
    Inventors: Lawrence G. Hamann, Yingzhi Bi, Mark C. Manfredi, Alexandra A. Nirschl, James C. Sutton
  • Bicyclic modulators of androgen receptor function
    Patent number: 7772267
    Abstract: There are provided compounds according to formula I wherein the substitutents are as described herein. Further provided are methods of using such compounds for the treatment of nuclear hormone receptor-associated conditions, such as age related diseases, for example sarcopenia. Also provided are pharmaceutical compositions containing such compounds and processes for preparing some of the compounds of the invention. Other embodiments are also disclosed.
    Type: Grant
    Filed: October 31, 2007
    Date of Patent: August 10, 2010
    Assignee: Bristol-Myers Squibb Company
    Inventors: Chong-qing Sun, Lawrence Hamann, David Augeri, Yingzhi Bi, Jeffrey Robl, Yan-Ting Huang, Tammy Wang, Alexandra Holubec, Ligaya Simpkins, James C. Sutton, James J. Li
  • (R)-PHENYL(HETEROCYCLE)METHANOL-BASED COMPOUNDS, COMPOSITIONS COMPRISING THEM AND METHODS OF THEIR USE
    Publication number: 20090286820
    Abstract: Multicyclic compounds, pharmaceutical compositions comprising them, and methods of their use are described.
    Type: Application
    Filed: May 19, 2009
    Publication date: November 19, 2009
    Inventors: Joseph Barbosa, Yingzhi Bi, Cynthia Anne Fink, Michael Alan Green, Jian Cheng Wang
  • (S)-PHENYL(HETEROCYCLE)METHANOL-BASED COMPOUNDS, COMPOSITIONS COMPRISING THEM AND METHODS OF THEIR USE
    Publication number: 20090181992
    Abstract: Multicyclic compounds and pharmaceutical compositions comprising them are described, along with methods of their use in the treatment of diseases such as age-associated memory impairment, Alzheimer's disease, Attention-Deficit/Hyperactivity Disorder (ADD/ADHD), autism, Down syndrome, Fragile X syndrome, Huntington's disease, Parkinson's disease, and schizophrenia.
    Type: Application
    Filed: March 24, 2009
    Publication date: July 16, 2009
    Inventors: Joseph Barbosa, Yingzhi Bi, Cynthia Anne Fink, Michael Alan Green, Jian Cheng Wang
  • Bicyclic modulators of androgen receptor function
    Patent number: 7405234
    Abstract: The invention provides compounds according to formula I wherein the substitutents are as described herein. Further provided are methods of using such compounds for the treatment of nuclear hormone receptor-associated conditions, such as age related diseases, for example sarcopenia. Also provided are pharmaceutical compositions containing such compounds and processes for preparing some of the compounds of the invention.
    Type: Grant
    Filed: February 17, 2004
    Date of Patent: July 29, 2008
    Assignee: Bristol-Myers Squibb Company
    Inventors: Chong-Qing Sun, Lawrence Hamann, David Augeri, Yingzhi Bi, Jeffrey Robl, Yan-Ting Huang, Tammy Wang, Alexandra Holubec, Ligaya Simpkins, James C. Sutton, James J. Li
  • (S)-PHENYL(HETEROCYCLE)METHANOL-BASED COMPOUNDS, COMPOSITIONS COMPRISING THEM AND METHODS OF THEIR USE
    Publication number: 20080146600
    Abstract: Multicyclic compounds, pharmaceutical compositions comprising them, and methods of their use are described.
    Type: Application
    Filed: November 5, 2007
    Publication date: June 19, 2008
    Inventors: Joseph Barbosa, Yingzhi Bi, Cynthia Anne Fink, Michael Alan Green, Jian Cheng Wang
  • (R)-PHENYL(HETEROCYCLE)METHANOL-BASED COMPOUNDS, COMPOSITIONS COMPRISING THEM AND METHODS OF THEIR USE
    Publication number: 20080146596
    Abstract: Multicyclic compounds, pharmaceutical compositions comprising them, and methods of their use are described.
    Type: Application
    Filed: November 5, 2007
    Publication date: June 19, 2008
    Inventors: Joseph Barbosa, Yingzhi Bi, Cynthia Anne Fink, Michael Alan Green, Jian Cheng Wang