Abstract: Disclosed is an isolated or purified T cell receptor (TCR) having antigenic specificity for mutated Kirsten rat sarcoma viral oncogene homolog (KRAS) presented in the context of an HLA-Cw*0802 molecule. Related polypeptides and proteins, as well as related nucleic acids, recombinant expression vectors, host cells, populations of cells, and pharmaceutical compositions are also provided. Also disclosed are methods of detecting the presence of cancer in a mammal and methods of treating or preventing cancer in a mammal.

Abstract: A base assembly includes a mounting structure and a support structure. The mounting structure includes a base body, a main body, and a guide rod provided between the base body and the main body. The support structure includes a sliding element and support legs. The sliding element is slidably connected to the guide rod. Each of the support legs is provided with a rotating end and a support end that are arranged opposite to each other. The rotating end is rotatably connected to the sliding element. The sliding element is slidable toward the main body to drive a plurality of support ends to approach each other, such that the base assembly is in a folded state. One of the base body and the support leg is provided with a first locking element, and the other of the base body and the support leg is provided with a second locking element.

Abstract: A base assembly includes a mounting structure and a support structure. The mounting structure includes a base body, a main body, and a guide rod provided between the base body and the main body. The support structure includes a sliding element and support legs. The sliding element is slidably connected to the guide rod. Each of the support legs is provided with a rotating end and a support end that are arranged opposite to each other. The rotating end is rotatably connected to the sliding element. The sliding element is slidable toward the main body to drive a plurality of support ends to approach each other, such that the base assembly is in a folded state. One of the base body and the support leg is provided with a first locking element, and the other of the base body and the support leg is provided with a second locking element.

Abstract: Compositions and methods for the treatment of viral infections include conjugates containing inhibitors of viral neuraminidase (e.g., zanamivir, peramivir, or analogs thereof) linked to an Fc monomer, an Fc domain, and Fc-binding peptide, an albumin protein, or albumin-binding peptide. In particular, conjugates can be used in the treatment of viral infections (e.g., influenza viral infections).

Abstract: Provided in the embodiments of the present disclosure are a blockchain-based method and system for handling domain name abuse. All network nodes in a public blockchain can report domain name abuse, and all network nodes receiving reported data are entitled to participate in the process of judging whether domain name abuse exists in the reported data. The public blockchain obtains a target judgment result of whether domain name abuse exists by means of integrating first judgment results of multiple identification nodes on whether domain name abuse exists in the reported data and credit value of each identification node. Alternatively, when the number of identification nodes in the public blockchain is less than a preset number of nodes, a consortium blockchain composed of regulatory agencies directly judges whether domain name abuse exists in the reported data, and the judgment result serves as the target judgment result.

Abstract: The present application provides an automated system and method for improving and generating annotated magnetic resonance (MRI) images based on magnetic resonance fingerprinting (MRF) data. The present disclosure also provides an automated method for generating the automated system for improving annotated MRI images. In some aspects, the method comprises accessing MRF data, MRI data, and images annotated with bulk-pixel labels that identify a tissue class for a group of patients. The annotated images can be used to train a machine learning system based on MRF data. The system can be trained to assign pixel labels to pixels outside the bulk-pixel labels to create an automated system. The automated system provided may be used to determine disease states using MRF data and generate machine-annotated images that include labels that indicate a tissue class. In this way, the present disclosure provides an automated system and method for improving incomplete annotations.

Abstract: Embodiments of the present disclosure provide a method and apparatus for processing a message header, a storage medium, and an electronic apparatus.

Abstract: Embodiments of the present disclosure provide a network configuration sending method and apparatus, a storage medium, and an electronic device. The method includes: determining N rule-action pairs corresponding to Quality of Service (QoS) configuration information of each layer in Hierarchical Quality of Service (HQoS) configuration, wherein the N rule-action pairs are used for representing network configuration rules and network configuration actions corresponding to the QoS configuration information, and N is a natural number greater than or equal to 1; and sending, to a forwarding plane of a Broadband Remote Access System (BRAS), target QoS configuration information mapped with the N rule-action pairs, wherein the forwarding plane is used for configuring the target QoS configuration information into a target device to configure a network of the target device.

Abstract: A fiber optic distribution box includes a box unit, a protective shield unit pivotally mounted on the box unit, and a plurality of mounting units detachably installed to the box unit for accommodating a plurality of adapters. The box unit includes a box body defining an interior space and a plurality of base brackets disposed on the box body and accommodated in the interior space. Each mounting unit includes a flanged seat and a tubular portion extending obliquely upwardly from the flanged seat.

Abstract: The present invention belongs to the technical field of marine exploration, and discloses a forward physical simulation method for seismic response characteristics of a marine natural gas hydrate system. A physical model is established according to distribution characteristics of a hydrate system in a research area; seismic response characteristics of natural gas hydrates and underlying free gas are determined; and a seismic interpretation result of the natural gas hydrate system is corrected according to a forward physical simulation result, so that forward physical simulation of the marine natural gas hydrate system is realized.

Abstract: The invention provides a microfluidic device comprising at least one cell culture chamber, the at least one cell culture chamber being connected to at least two openings, the device being configured to supply at least one physiologically active substance from at least one of the openings to the at least one cell culture chamber in such a manner as to form a concentration gradient or concentration gradients in the at least one chamber when cells and a hydrogel are introduced into the at least one cell culture chamber to culture the cells in a 3D-gel medium.

Abstract: A device includes a substrate retainer for retaining a substrate thereon, and a ring assembly including an upper ring which has a plurality of upper ring segments that are angularly displaced from each other. Each of the upper ring segments is movable between an inner position and an outer position so as to adjust a gap between an outer periphery of the substrate and an inner edge of each of the upper ring segments when the substrate is retained on the substrate retainer.

Abstract: A liquid introduction apparatus for introducing glue or other liquid into a product includes a platform and a housing mounted to the platform for defining a confined space. The confined space can form a sealed vacuum environment, and an introduction mechanism is arranged on the platform and is configured for introducing liquid into the product in a vacuum environment by discharging air from the confined space. The disclosure also provides an adhesive dispensing apparatus.

Abstract: Embodiments of the present disclosure provide an image processing method based on artificial intelligence (AI) and an image processing system. The method includes: obtaining a feature recognition result of an image by performing image processing on the image to recognize a feature of the image and the image being obtained by performing image acquisition on a section of a patient using a digital slide scanner to generate a whole slide image (WSI) as the image; determining an imaging area of the section within a field of view of an eyepiece of a microscope with which real-time imaging is performed on the section; determining, within the image, an image area corresponding to the imaging area of the section and acquiring, from the feature recognition result of the image, a target feature recognition result of the image area; and superimposing the target feature recognition result on the imaging area of the section.

Abstract: The present application discloses a 3D printing device and a release method and a liquid containing mechanism therefor, and relates to the field of 3D printing. The liquid containing mechanism comprises a material box foundation, a material box and a plurality of motion guide components. The material box foundation is a rigid annular plate with a mounting groove and is detachably mounted on a base of the 3D printing device, the mounting groove of the material box foundation is covered by a light-transmitting glass plate, and the glass plate is fixed on an upper surface of the material box foundation. The plurality of motion guide components are fixed to a peripheral edge of the material box and then detachably fixed on the material box foundation. Each of the motion guide components is a following component with an upper limit structure and a lower limit structure, and the following component is fixed to the peripheral edge of the material box.

Abstract: Logic may store data structures for two or more processors in memory such as cache, system management memory, protected memory, or other memory. Logic may compress the data structures to be stored in the memory. Logic may determine a reference data structure, store the reference data structure in the memory, determine a difference between a data structure for a second processor and the reference data structure, and store the difference in the memory. Logic may store the difference in the memory within a data structure such as a linked list or a bitmap. Logic may decompress the difference by combining the difference with the reference data structure. Logic may expand the useable data region to include cache in the two or more processors. Logic may instruct two or more processors to store their processor data structures in their respective caches and perform initialization with the processor data structures.

Abstract: A method includes forming an inner chamber in a process chamber of a plasma processing apparatus, the inner chamber having smaller volume than the process chamber. At least one gas is introduced into the inner chamber, and flow of the at least one gas into the inner chamber is measured. The flow of the at least one gas is adjusted to a desired rate, and a wafer is processed by the at least one gas at the desired rate while the inner chamber is not formed.