Abstract: An example operation may include one or more of monitoring a plurality of brokers within a cluster to identify current workload attributes of the plurality of brokers, determining a health value of a lead broker within the cluster via execution of a machine learning model on current workload attributes of the lead broker, determining to modify resources assigned to the lead broker based on the determined health value of the lead broker, executing an optimization algorithm on the current workload attributes of the plurality of brokers within the cluster to determine an optimum task distribution, and reallocating tasks amongst the lead broker and the one or more other brokers within the cluster based on the optimum task distribution.

Abstract: Receiving a map update indication message from a map server; sending a first map update query request message to an OTA upgrade master node apparatus in a vehicle based on the map update indication message; receiving a first map update query feedback message that is fed back by the OTA upgrade master node apparatus based on the first map update query request message; sending a map data download start message to the map server in response to the first map update query feedback message; receiving map update data sent by the map server; and updating a map in the vehicle based on the map update data.

Abstract: A semiconductor device having a cell region, the cell region including a first set of one or more first blocks and a second set of one or more second blocks. Each of the first blocks including a clock gate and each of the second blocks includes a decoupling capacitor. The first set has two or more first blocks and/or the second set has two or more second blocks. The first blocks of the first set are interleaved with the second blocks of the second set.

Abstract: The invention relates to a computer implemented method and system for analyzing a video.

Abstract: Some embodiments of the invention provide a method for transmitting data messages via secure tunnels in a network. The method is performed at a gateway device. The method determines that a data message received at the gateway device should be sent via a secure interface of the gateway device. The method matches the data message to a firewall rule that maps to a particular secure tunnel used by the secure interface, with multiple different firewall rules mapping to multiple different secure tunnels used by the secure interface. The method encapsulates the data message with a header that comprises an indicator value specifying the particular secure tunnel and forwards the encapsulated data message to a destination interface.

Abstract: Some embodiments of the invention provide a system for implementing multiple logical routers. The system includes a Kubernetes cluster that includes multiple nodes, with each node executing a set of pods. The set of pods include a first pod for performing a first set of data message processing operations for the multiple logical routers and at least one respective separate pod for each respective logical router of the multiple logical routers. Each respective pod is for performing a respective second set of data message processing operations for the respective logical router.

Abstract: A polypeptide or protein directional modification method based on sulfhydryl-alkenyl azide coupling is provided. The method uses a sulfhydryl group-containing compound and a compound containing alkenyl azide group as reactants to generate an amino acid containing ?-carbonyl sulfide, a polypeptide containing ?-carbonyl sulfide and a protein bioconjugate containing ?-carbonyl sulfide, thereby achieving a chemical modification. The method is mild in conditions and wide in solvent selectivity, a reaction temperature is in a range of 37 degrees Celsius (° C.) to 40° C., and a reaction time is in a range of 10 minutes to 48 hours. The method is promising in preparing functional polypeptides or functional proteins, protein labeling, and biological medicine.

Abstract: Heterocyclic compounds useful as antagonists of adenosine receptors, and methods of treatment of diseases using antagonists of adenosine receptors are disclosed herein. Also disclosed herein are pharmaceutical compositions and methods of administration of heterocyclic antagonists of adenosine receptors and processes for producing heterocyclic antagonists of adenosine receptors.

Abstract: An IC structure includes first and second gates, first and second source regions, a shared drain region, and an isolation region. The first gate has a first portion extending along a first direction and a second portion extending along a second direction. The second gate has a first portion extending along the first direction and a second portion extending along the second direction. The shared drain region extends from the first portion of the first gate to the first portion of the second gate. The first source region is spaced apart from the shared drain region by the first gate. The second source region is spaced apart from the shared drain region by the second gate. The isolation region is between the first portion of the first gate and the first portion of the second gate, and resembles a quadrilateral pattern bordering the shared drain region.

Abstract: One or more computer processors encode a plurality of time sequenced global position system (GPS) datapoints onto a grided dimensional area; determine a general trajectory between each time sequenced GPS datapoint in the plurality of encoded time sequenced GPS datapoints and a subsequent encoded time sequenced GPS datapoint; cluster the encoded time sequenced GPS datapoints based on a respective determined trajectory with a plurality of encoded historical GPS datapoints; calculate an azimuth for each encoded time sequenced GPS datapoint in the plurality of time sequenced GPS datapoints utilizing a plurality of adjacent historical GPS datapoints contained within a respective cluster; generate a plurality of interpolated GPS datapoints utilizing calculated azimuths, determined general trajectories, and historical GPS datapoints; and aggregate the generated interpolated GPS datapoints with the plurality of time sequenced GPS datapoints into an interpolated route, wherein each GPS datapoint in the interpolated ro

Abstract: Disclosed herein are compounds of Formula (I?). Compounds of Formula (I?) inhibit, regulate and/or modulate kinase receptor, particularly Axl and Mer signal transduction pathways related to the changes in cellular activities as mentioned above, compositions which contain these compounds, and methods of using them to treat kinase-dependent diseases and conditions. The present invention also provides methods for making compounds as mentioned above, and compositions which contain these compounds.

Abstract: A nanobody and its application based on SARS-CoV-2 S protein are provided, and the present disclosure relates to biomedical technology. The present disclosure chooses the Spike S1+S2 ECD of SARS-CoV-2 as a target, and screens the nanobody against of SARS-CoV-2 by using a nanobody library. After an ELISA test, the Spike S1+S2 ECD target of SARS-CoV-2 can be specifically identified while a SPIKE RBD target is identified, and a binding signal is relatively strong. The corresponding nanobody sequence is constructed into a prokaryotic expression vector for expression and purification to express the target nanobody successfully. After the purification, the purity is greater than 90%. The ELISA test of VHH nanobody showed that the purified nanobody has higher affinity to the two targets.

Abstract: Described herein are systems, methods, and software to manage the selection of an edge gateway or edge for processing a packet. In one implementation, a first edge may receive a packet and hash addressing information in the packet to select a second edge to process the packet. The first edge may further forward the packet to the second edge, permitting the second edge to process the packet. Once processed, the second edge may forward the packet to a destination host computing system and notify the host computing system to use the second edge for response packets directed at a source internet protocol (IP) address in the packet.

Abstract: In some implementations, a storage node receives data processing instructions from a compute node of a network architecture. The storage node detects a Directed Acyclic Graph (DAG) within the data processing instructions. The DAG includes a plurality of data processing operations arranged within the DAG according to an execution. The data processing operations further include user-defined function (UDF) information associated with a UDF. The storage node may retrieve a first data object from an object store of the distributed storage node based on object keys information within the plurality of data processing operations. The storage node may execute the plurality of data processing operations using the retrieved first data object to generate a DAG execution result, the executing of the plurality of data processing operations based on the execution order. The storage node may communicate the DAG execution result to the compute node in response to the data processing instructions.

Abstract: An uplink transmission method, a terminal, and a network side device are provided. The method includes: determining, by the terminal, a first duration according to first information; and performing multiple first uplink transmissions on a first serving cell based on the first duration, where the multiple first uplink transmissions meet a predetermined requirement.

Abstract: For a network including multiple computers acting as tunnel endpoints in a network, some embodiments provide a method for processing data messages in parallel using multiple processors (e.g., cores) of each computer. Each computer in some embodiments has a set of interfaces configured as tunnel endpoints connecting to multiple tunnels. In some embodiments, the multiple processors encrypt data messages according to a set of encryption parameters or multiple sets of encryption parameters that specify an encryption policy for data messages requiring encryption, an encryption algorithm, an encryption key, a destination network address, and an encryption-parameter-set identifier.

Abstract: A novel design of a gateway that handles traffic in and out of a network by using a datapath pipeline is provided. The datapath pipeline includes multiple stages for performing various data-plane packet-processing operations at the edge of the network. The processing stages include centralized routing stages and distributed routing stages. The processing stages can include service-providing stages such as NAT and firewall. The gateway caches the result previous packet operations and reapplies the result to subsequent packets that meet certain criteria. For packets that do not have applicable or valid result from previous packet processing operations, the gateway datapath daemon executes the pipelined packet processing stages and records a set of data from each stage of the pipeline and synthesizes those data into a cache entry for subsequent packets.

Abstract: The disclosure relates to a preparation method and use of a pyrazole compound containing 1-(3,4-dimethoxyphenyl)-?-carboline unit. The pyrazole compound is prepared by reacting pyrazole aldehyde and 1-(3,4-dimethoxyphenyl)-?-carboline acylhydrazine. The pyrazole compound containing 1-(3,4-dimethoxyphenyl)-?-carboline unit has good inhibitory activity against tumor cell HGC-27. The pyrazole compound could be used in the preparation of anti-tumor drugs.

Abstract: The present disclosure provides methods and compositions for tracking nucleic acid fragment origin by target-specific barcode tagging when original nucleic acid targets break into small fragments. Nucleic acid targets are captured in vitro on a solid support with clonally localized nucleic acid barcode templates. Many nucleic acid targets canbe processed simultaneously in a massively parallel fashion without partition. These nucleic acid target tracking methods can be used for a variety of applications in both whole genome sequencing and targeted sequencing in order to accurately identify genomic variants, haplotype phasing and assembly, for example.