Abstract: The present application discloses a camptothecin drug and its antibody conjugate. Based on a comprehensive understanding of ADC drugs, the inventor designed a series of active anti-tumor exatecan-derivatives. The designed anti-tumor molecular compound showed good anti-tumor activity in the experiment.

Abstract: An array substrate and a touch display device. The array substrate includes a touch signal line, a common electrode and a first pixel electrode on a substrate. The first pixel electrode includes a first edge and a second edge arranged along the first direction and extending along the second direction, the touch signal line extends along the second direction, and the touch signal line is located between the first edge and the second edge. The via hole connection part of the touch signal line is electrically connected to the common electrode through the touch line via hole, and a size of the via hole connection part in the first direction is greater than a size of a portion of the touch signal line in the first direction, and the portion of the touch signal line is adjacent to the via hole connection part.

Abstract: Disclosed are a display panel and a driving method therefor, and a display device. Two adjacent rows of sub-pixels are taken as a row group, and the row group is provided with a first sub row group and a second sub row group that are arranged in a column direction; a gate electrode of a first transistor in the first sub row group is electrically connected to a first gate line; a gate electrode of a second transistor in the second sub row group is electrically connected to a second gate line; two adjacent sub-pixels in the column direction share one third transistor, and a gate electrode of the third transistor in the row group is electrically connected to a third gate line; and the first transistor and the second transistor in one column of sub-pixels are electrically connected to a data line by means of the shared third transistor.

Abstract: An electronic paper display screen and a manufacturing method therefor, and a display device. The electronic paper display screen includes a first electronic paper screen and a second liquid crystal display layer which are stacked; the first electronic paper screen is an electrophoretic electronic paper screen, the second liquid crystal display layer is a cholesteric liquid crystal display screen, and the second liquid crystal display layer includes a first substrate, a second substrate and a control drive circuit; the first substrate is provided with multiple first electrodes arranged in a first direction, and the second substrate is provided with multiple second electrodes arranged in a second direction; and at least one of the first substrate and the second substrate is further provided with multiple metal wires, the metal wires are respectively connected to the control drive circuit and the electrodes of the substrate to which the metal wires belong.

Abstract: Novel antibody-drug conjugates (ADCs) and methods of using such ADCs to treat proliferative disorders are described herein. The ADCs may comprise a PARP protein automodified with a plurality of poly-ADP-ribose polymers functionalized with novel NAD+ analogues. The automodified PARP with functionalized poly-ADP-ribose polymers provide a novel type of drug carrier, which allows facile conjugation of monoclonal antibodies and cytotoxic drug in high ratios.

Abstract: The present invention relates to a multi-postbiotics-compounded rejuvenating essence, which includes the following components in percentage by weight: 8.0-13.0% of butanediol, 2.0-3.0% of triglyceride octoate/caprate/succinate, 2.0-3.0% of polyglutamate sodium, 0.5-1.0% of extract of Japanese Ardisia herb stems, 0.5-1.0% of yeast/rice ferment filtrate, 0.5-1.0% of fission yeast mycelium ferment filtrate, 0.5-1.0% of lactobacillus/mung bean extract/sodium glutamate ferment filtrate, 0.5-1.0% of lactobacillus ferment, 0.5-1.0% of bacillus/rice bran extract/soybean extract ferment filtrate, 0.5-1.0% of Streptococcus thermophilus ferment, 0.1-0.2% of collargol, and 65.3-79.4% of deionized water, wherein the essence is put in an airtight container and is injected with hydrogen.

Abstract: A charging output protection circuit and a charging output protection method. The charging output protection circuit includes a battery pack, a charger, a hardware control unit, and a software control unit, the hardware control unit including a detecting circuit for detecting whether a voltage of the battery pack is normal, a first triode connected to the detecting circuit, and a first a relay, the first triode is configured to control the first relay to be switched off or on based on the detection result of the detecting circuit; the software control unit includes a single chip microcomputer, a communication circuit for communicating between the single chip microcomputer and the battery pack, a second triode and a second relay connected to the single chip microcomputer, and the second triode is used for controlling the second relay to be switched off or on based on the instruction of the single chip microcomputer.

Abstract: Provided is use of tectorigenin in the preparation of a medicament for treatment of chicken necrotic enteritis. Using tectorigenin for treating chicken necrotic enteritis can significantly reduce the degree of pathological changes in the intestinal tract of chickens with necrotic enteritis, and has a good therapeutic effect on chicken necrotic enteritis caused by Clostridium perfringens.

Abstract: A ground collision avoidance method in an ownship vehicle is disclosed. The method includes: retrieving position measurements for the ownship vehicle and for a dynamic obstacle; retrieving mapping data from an airport map database that includes coordinate data for airport travel pathways; adjusting a position measurement for the ownship vehicle and a position measurement for the dynamic obstacle based on coordinate data retrieved from the airport map database and historical aircraft movement data; predicting a series of future positions for the ownship vehicle that are constrained by airport surface operation rules; predicting a series of future positions for the dynamic obstacle that are constrained by airport surface operation rules; calculating whether a potential collision is imminent; and causing a collision alert to be displayed when the processor has determined that a potential collision between the ownship vehicle and the dynamic obstacle is imminent.

Abstract: A multi-purpose internal component for an aerosol-generating product includes a hollow cylinder and air-permeable sealing members located at two ends of the hollow cylinder, where the hollow cylinder is filled with a functional material. The hollow cylinder can be filled with a smoke-generating material, a material with cooling, fragrance-enhancing, and harm-reducing functions, a filter material, and the like, such that multiple functions can be achieved; and the air-permeable sealing members at the two ends enable an air-flow channel. The internal component for an aerosol-generating product is simple and widely used in aerosol-generating products. An aerosol-generating product using the multi-purpose internal component for an aerosol-generating product is provided, where the multi-purpose internal component for an aerosol-generating product can be used as an aerosol-generating component, a multi-functional component, or a filter component.

Abstract: The present disclosure provides an injection pen needle, which includes a needle head, a needle seat, an outer sleeve, a sliding sleeve and a limit ring, wherein the needle head is arranged on the needle seat; the needle seat comprises baffle plates; the outer sleeve is arranged on the needle seat in a sleeving manner; the lower part of the sliding sleeve enters the outer sleeve and is adapted to move up and down in the outer sleeve, and a channel hole, from which the needle head can penetrate out, is formed in the top of the sliding sleeve; the limit ring is arranged in the outer sleeve; the limit ring comprises sliding blocks; the bottom of the sliding sleeve pushes against the limit ring; and when the sliding sleeve moves up and down in the outer sleeve.

Abstract: Disclosed are an electrical penetration assembly, a manufacturing method thereof, and an electrical penetration device, which relate to the technical field of electrical penetration.

Abstract: A phase shifter that includes an RF splitter is disclosed. The RF splitter is arranged so that an RF input signal is provided to, and split over portions of, a feed line that connects an antenna element with a radio transmitter/receiver/transceiver, thus realizing a feed line splitter. Feed line splitters described herein are provided with switches that allow changing a point at which the RF input signal is fed to the feed line, where the switches may be semiconductor-based or MEMS-based switches. The point at which the RF input signal is provided to the feed line to be split defines the electrical path length that the RF energy will travel down each respective path of the feed line splitter, which, in turn, changes the phase shift realized at each output of the feed line splitter. Different antenna elements may be coupled to different outputs of the feed line splitter.

Abstract: An intelligent lock guard device, including a box body, the box body includes an upper box cover and a lower box body being buckled to form a hollow box body; the protection lock, including a lock catch and a lock body mechanism; the lock catch includes a fixing crossbeam and a locking rod, the fixing crossbeam is fixed on the upper box cover, and the locking rod is provided with a locking hole; the locking body mechanism, including a lock shaft, a toothed belt and a motor; the locking body mechanism is fixed on the lower box body; the lock shaft is provided with a lock cylinder convex bar, and the track of the toothed belt is parallel to the direction in which the lock cylinder convex bar is inserted or removed from the locking hole.

Abstract: A double Schottky-barrier diode includes a semi-insulating substrate, a left mesa formed by growth and etching on the semi-insulating substrate, a middle mesa formed by growth and etching on the semi-insulating substrate, a right mesa formed by growth and etching on the semi-insulating substrate, two anode probes and two air-bridge fingers. The two Schottky contacts are closely fabricated on the same mesa (middle mesa) in a back-to-back manner to obtain even symmetric C-V characteristics and odd symmetric I-V characteristics from the device level. The output of a frequency multiplier fabricated using the double Schottky-barrier diode only has odd harmonics, but no even harmonics, which is suitable for the production of high-order frequency multipliers. The cathodes of the two Schottky contacts are connected by the buffer layer without ohmic contact.

Abstract: The present invention is directed to a manifold for directing cooling fluid and/or gas to a heat exchanger in a flow configuration designed to optimize heat transfer from the heat exchanger. The manifold can take many different forms such as a layered construction with distributed inlet paths, local outlet paths, a central collection changer and a path for fluid removal. The manifold can be formed from a metal, plastic, rubber, ceramic, or other heat resistant material known to or conceivable by one of skill in the art. The manifold can also be combined with any type of heat exchanger known to or conceivable by one of skill in the art to form a thermal management unit. To optimize overall properties such as low pressure drop, high heat transfer, and excellent temperature uniformity of the thermal management unit, the manifold can be graded, expanded and scaled as needed.

Abstract: A pipelined analog-to-digital converter and an output calibration method for the same. The pipelined analog-to-digital converter introduces an error calibration mechanism on the basis of traditional pipelined analog-to-digital converters through a control module, an equivalent gain error extraction module, an error storage module and a coding reconstruction module to compensate for gain errors and setup errors caused by operational amplifiers in a pipelined conversion module, so that the analog-to-digital conversion accuracy is improved, and requirements for the gain and bandwidth of the operational amplifier are relaxed, which can effectively reduce the power consumption of the analog-to-digital converter and the complexity of the corresponding analog circuit; a curve fitting method is adopted to obtain an ideal output sequence and then calculate errors; meanwhile, extraction and calibration of equivalent gain errors are all done in digital ways, and therefore accuracy thereof is high.

Abstract: A connecting device and an assembly of the connecting device and a mating device are provided. The connecting device includes an insulating main body, a plurality of terminals, a magnet set, an inner housing, a crown leaf spring, an outer housing, and a wave spring. The plurality of terminals are disposed on the insulating main body, the magnet set is disposed on the insulating main body, and the inner housing is sleeved around the insulating main body. The wave spring and the crown leaf spring are each disposed between the inner housing and the outer housing, and abut the inner housing, so that the insulating main body, the plurality of terminals, the magnet set, and the inner housing are arranged in a floating state.

Abstract: Provided is a method of preparation of (1R, 3S)-3-amino-1-cyclopentanol, the method including: contacting N-acylhydroxyamine and cyclopentadiene for an asymmetric cycloaddition, to yield a first intermediate I; hydrogenating the first intermediate I to yield a second intermediate II; hydrolyzing, ammonolyzing, hydrazinolyzing, or alcoholyzing an amido bond of the second intermediate II to yield a third intermediate III; and hydrogenating the third intermediate III to yield (1R, 3S)-3-amino-1-cyclopentanol.