Abstract: Disclosed are an automatic stable posture seabed base and a releasing method, belonging to the technical field of ocean observation. The automatic stable posture seabed base includes an accommodating body with an inner cavity for accommodating the first observation device and a seawater, and the accommodating body has first through holes for the seawater to enter and outflow the inner cavity; plugging members blocked at the first through holes to close or semi-close the first through holes; and a buoyancy body installed at a transducer of the first observation device, and a buoyancy of the buoyancy body is larger than a mass of the first observation device, so that the first observation device may float in the cover body after the cover body is filled with water, and a posture of the transducer in the cover body always keeps vertically to the sea surface.

Abstract: An on-line multi-component gas analysis system based on a spectral absorption technology includes a housing, wherein the housing includes an air inlet hole and an air outlet hole which are respectively connected with an air inlet pipe and an air outlet pipe, and the housing includes a dust removal and dehumidification device, a micro vacuum pump, an electronic flowmeter, and a plurality of different gas sensors; the dust removal and dehumidification device, which is configured to perform dust removal and dehumidification treatment on a gas entering from the air inlet hole; the micro vacuum pump, one end of which being connected with the dust removal and dehumidification device through a pipeline, and the other end of which being connected with the electronic flowmeter; and the plurality of different gas sensors. The disclosure includes an analysis method based on the on-line multi-component gas analysis system based on a spectral absorption technology.

Abstract: The present disclosure provides use of Clostridium ghonii combined with a tumor angiogenesis inhibitor in preparing a pharmaceutical product for treating a tumor. The present disclosure further provides a drug for treating a tumor, where the drug includes active ingredients of Clostridium ghonii and a tumor angiogenesis inhibitor.

Abstract: Disclosed are methods of isolating paired T cell receptor (TCR) alpha and beta chain sequences, or an antigen-binding portion thereof. Also disclosed are methods of automatically identifying the TCR alpha and beta chain V segment sequences and CDR3 sequences of a TCR having antigenic specificity for a mutated amino acid sequence encoded by a cancer-specific mutation. Methods of preparing a population of cells that express paired TCR alpha and beta chain sequences, or an antigen-binding portion thereof, are also disclosed. Isolated pairs of TCR alpha and beta chain sequences and isolated populations of cells prepared by the methods are also disclosed.

Abstract: Provided are a method and apparatus for sending a channel state, a method and apparatus for receiving a channel state and a storage medium. The method for sending a channel state includes following steps: a channel state report for characterizing a channel state comprising a precoding matrix is determined; and the channel state report for characterizing the channel state comprising the precoding matrix is sent, where the channel state report includes: a number of reported coefficients in coefficient matrixes for the precoding matrix and the reported coefficients in the coefficient matrixes for the precoding matrix; where the reported coefficients in the coefficient matrixes for the precoding matrix are used for indicating the precoding matrix.

Abstract: A low shrink tension packaging film contains a first polymer that is an ethylene-unsaturated carboxylic acid copolymer and a second polymer containing one or more copolymers selected from an ethylene-vinyl acetate copolymer and an ethylene-acrylate copolymer. A molar ratio of a specific structural unit of the first polymer to a specific structural unit of the second polymer is in a specific range, such that the low shrink tension packaging film has excellent optical and mechanical properties and a significantly low tension applied when being shrunk by heat.

Abstract: The present disclosure relates to use of a Clostridium ghonii spore combined with pembrolizumab in cancer treatment. It is found for the first time that the Clostridium ghonii spore combined with pembrolizumab can significantly improve a curative effect of colon cancer and reduce a dose of the pembrolizumab, and thus is efficient and low-toxic. Oncolysis by Clostridium ghonii can affect immunogenicity of a tumor microenvironment (TME) by various ways, converts an immunosuppressive state of the TME into an immune-activated state, adjusts the immunosuppressive TME, and breaks an immune tolerance. An optimal combination of the Clostridium ghonii spore and the pembrolizumab thoroughly removes about 20% of mouse tumor tissues. A benefit range of patients with tumors treated by a PD-1 antibody is expanded. The combination even has an obvious curative effect on patients failed the treatment by the PD-1 antibody.

Abstract: The present invention belongs to the field of medicinal chemistry and relates to a class of substituted tricyclic compounds as PRMT5 inhibitors and the use thereof. Specifically, the present invention provides a compound represented by formula (A) or an isomer, pharmaceutically acceptable salt, solvate, crystal or prodrug thereof, a preparation method therefor, a pharmaceutical composition containing the compounds, and the use of the compounds or the composition for treating a disease mediated by PRMT5. The compounds of the present invention show significant inhibitory activity on PRMT5.

Abstract: A flyback converter control architecture is provided in which primary-only feedback techniques are used to ensure smooth startup and detection of fault conditions. During steady-state operation, secondary-side regulation is employed. In addition, current limits are monitored during steady-state operation using primary-only feedback techniques to obviate the need for a secondary-side current sense resistor.

Abstract: A switching power converter is provided that communicates with a mobile device to receive a value of a load detection current. The switching power converter adjusts the cycling of a power switch until a constant current mode of operation is entered with a known output current driving the mobile device. The switching power converter subtracts the load current from the output current to measure a soft-short circuit current.

Abstract: The present invention provides PD-1 monoclonal antibodies, particularly human monoclonal antibodies of PD-1, which specifically bind to PD-1 with high affinity and comprise a heavy chain and a light chain. The present invention further provides nucleic acid sequence encoding the antibodies of the invention, cloning or expression vectors, host cells and methods for expressing or isolating the antibodies. Immunoconjugates, therapeutic compositions comprising the antibodies of the invention are also provided. The invention also provides methods for treating various cancers with anti-PD-1 antibodies.

Abstract: The present disclosure discloses a method for execution of a computational graph in a neural network model and an apparatus thereof, including: creating task execution bodies on a native machine according to a physical computational graph compiled and generated by a deep learning framework, and designing a solution for allocating a plurality of idle memory blocks to each task execution body, so that the entire computational graph participates in deep learning training tasks of different batches of data in a pipelining and parallelizing manner.

Abstract: In response to receiving a request for an identity key from a first entity, an identity key for the first entity is generated. A first request from the first entity to replicate a set of data is received. The generated identity key for the first entity is added to the metadata of the set of data requested to be replicated. A determination is made whether a replication rule exists for the first entity. In response to determining that a replication rule exists for the first entity, the set of data is replicated according to the replication rule for the first entity.

Abstract: A well cementing method is described for improving cementing quality by controlling the hydration heat of cement slurry. By controlling the degree and/or rate of hydration heat release from cement slurry, the method improves the hydration heat release during formation of cement with curing of cement slurry, improves the binding quality between the cement and the interfaces, and in turn improves the cementing quality at the open hole section and/or the overlap section. The cementing method improves cementing quality of oil and gas wells and reduces the risk of annular pressure.

Abstract: Provided are a channel state information transmission method and apparatus, an electronic device, and a storage medium. The channel state information transmission method includes determining configuration information, transmitting the configuration information to a terminal, and receiving channel state information which is reported according to the configuration information by the terminal. The configuration information includes at least one of the size of a subband, a channel state information reporting band, the number R of precoding matrix subbands contained in each subband, or report content of the channel state information. The report content of the channel state information includes a precoding matrix indicator (PMI).

Abstract: Provided are CSI feedback and receiving methods, apparatuses, a device, and a storage medium. The method includes: a terminal determines PMI, the PMI includes at least one of: first base vector information, second base vector information, second coefficient amplitude information or phase information; for one transmission layer, a frequency domain resource in one preset frequency domain unit corresponds to one precoding vector, the precoding vector is a linear combination of first base vectors, and weighting coefficients used in the linear combination of the first base vectors are first coefficients; on multiple frequency domain units contained in a CSI feedback band, a vector composed of first coefficients corresponding to a same first base vector is a linear combination of second base vectors, and weighting coefficients used in the linear combination of the second base vectors are second coefficients; and the terminal feeds back CSI containing the PMI to a base station.

Abstract: Provided are novel fully human monoclonal antibodies that bind to human LAG-3. It also provides the methods of hybridoma generation using humanized rats, the nucleic acid molecules encoding the anti-LAG-3 antibodies, expression vectors and host cells used for the expression of anti-LAG-3 antibodies. The invention further provides the methods for validating the function of antibodies in vitro. The antibodies of invention provide a potent agent for the treatment of multiple cancers via modulating human immune function.

Abstract: A plasma processing system for cleaning a substrate is provided. The plasma processing system includes a process chamber that includes: a chamber body enclosing an interior volume; and a substrate support disposed in the interior volume. The plasma processing system includes a vacuum pump; a first exhaust line fluidly coupled between the interior volume of the process chamber and the vacuum pump; and a second exhaust line fluidly coupled between the interior volume of the process chamber and the vacuum pump. The first exhaust line and the second exhaust line are arranged to provide alternative paths for the exhaust between the interior volume and the vacuum pump, and the first exhaust line has an internal diameter that is at least 50% smaller than the internal diameter of the second exhaust line.

Abstract: Provided are anti-CD40 agonistic antibodies, the nucleic acid molecules encoding the anti-CD40 antibodies, expression vectors and host cells used for the expression of anti-CD40 antibodies. Further provided are the methods for validating the function of antibodies in vitro and the efficacy of antibodies in vivo. The antibodies provide a very potent agent for the treatment of cancers via modulating immune functions.

Abstract: The present disclosure provides monoclonal antibodies against protein programmed cell death 1 (PD-1), which can block the binding of PD-1 ligands to PD-1, and therefore block the inhibitory function of PD-1 ligands on PD-1 expressing T cells. The antibodies of disclosure provide very potent agents for the treatment of multiple cancers via modulating human immune function.