Abstract: The present application relates to the technical field of pharmaceutical chemistry, and particularly relates to compounds with ALK inhibitory activity and preparation method and use thereof. The compounds with ALK inhibitory activity provided by the present application are ALK inhibitors for treating diseases responsive to the inhibition of ALK kinase, can be used for treating ALK-positive diseases, such as tumors and cancers, and have broad application prospects.

Abstract: The present application provides mask plate, fabrication method thereof, and mask plate assembly. The mask plate includes two opening areas being respectively on different sides of mask pattern area along first direction, and two welding areas. One welding area is on a side of one opening area away from the mask pattern area along first direction, and the other welding area is on a side of the other opening area away from mask pattern area along first direction. Evaporation holes are arranged in mask unit, buffer holes are arranged in each opening area, and ratio of maximum dimension of buffer hole in any direction in plane where the mask plate is located to maximum dimension of evaporation hole in the direction is greater than 100. Buffer holes are distributed at equal intervals along a second direction, and second direction is in the plane and is perpendicular to first direction.

Abstract: A mask has a mask pattern region and a non-mask pattern region located at a peripheral of the mask pattern region. The mask pattern region includes at least one effective mask region. In any effective mask region, the mask includes a plurality of evaporation holes and at least one shielding; strip. Each shielding, strip is located between two adjacent evaporation holes. The mask has at least one welding region in the non-mask pattern region. A thickness of a portion of the mask in the non-mask pattern region and at least in the welding region is greater than a thickness of the shielding strip of the mask in the effective mask region, and the thickness refers to a dimension of the corresponding portion along a direction perpendicular to a plane where the mask is located.

Abstract: Provided are an ionomer composition including silica particles which satisfy a specific equation and are acidic in an aqueous solution state and an ionomer film produced therefrom. The ionomer composition has excellent miscibility, and when a film is produced using the composition, surface appearance such as transparency is well-improved, and wear resistance, coefficient of friction, and the like of the film are significantly improved.

Abstract: A low shrink tension packaging film contains a first polymer that is an ethylene-unsaturated carboxylic acid copolymer and a second polymer containing one or more copolymers selected from an ethylene-vinyl acetate copolymer and an ethylene-acrylate copolymer. A molar ratio of a specific structural unit of the first polymer to a specific structural unit of the second polymer is in a specific range, such that the low shrink tension packaging film has excellent optical and mechanical properties and a significantly low tension applied when being shrunk by heat.

Abstract: The present invention provides PD-1 monoclonal antibodies, particularly human monoclonal antibodies of PD-1, which specifically bind to PD-1 with high affinity and comprise a heavy chain and a light chain. The present invention further provides nucleic acid sequence encoding the antibodies of the invention, cloning or expression vectors, host cells and methods for expressing or isolating the antibodies. Immunoconjugates, therapeutic compositions comprising the antibodies of the invention are also provided. The invention also provides methods for treating various cancers with anti-PD-1 antibodies.

Abstract: A dual-band HP omnidirectional antenna includes an electrically small (ES) first omnidirectional loop antenna for a first band, and a second omnidirectional loop antenna for a second band. The first omnidirectional loop antenna and the second omnidirectional loop antenna are capable of operating independently in the first band and the second band. A loading effect of the second omnidirectional loop antenna adapted to suppress a higher-order mode of the first omnidirectional loop antenna.

Abstract: In response to receiving a request for an identity key from a first entity, an identity key for the first entity is generated. A first request from the first entity to replicate a set of data is received. The generated identity key for the first entity is added to the metadata of the set of data requested to be replicated. A determination is made whether a replication rule exists for the first entity. In response to determining that a replication rule exists for the first entity, the set of data is replicated according to the replication rule for the first entity.

Abstract: Provided are novel fully human monoclonal antibodies that bind to human LAG-3. It also provides the methods of hybridoma generation using humanized rats, the nucleic acid molecules encoding the anti-LAG-3 antibodies, expression vectors and host cells used for the expression of anti-LAG-3 antibodies. The invention further provides the methods for validating the function of antibodies in vitro. The antibodies of invention provide a potent agent for the treatment of multiple cancers via modulating human immune function.

Abstract: A plasma processing system for cleaning a substrate is provided. The plasma processing system includes a process chamber that includes: a chamber body enclosing an interior volume; and a substrate support disposed in the interior volume. The plasma processing system includes a vacuum pump; a first exhaust line fluidly coupled between the interior volume of the process chamber and the vacuum pump; and a second exhaust line fluidly coupled between the interior volume of the process chamber and the vacuum pump. The first exhaust line and the second exhaust line are arranged to provide alternative paths for the exhaust between the interior volume and the vacuum pump, and the first exhaust line has an internal diameter that is at least 50% smaller than the internal diameter of the second exhaust line.

Abstract: The present disclosure provides monoclonal antibodies against protein programmed cell death 1 (PD-1), which can block the binding of PD-1 ligands to PD-1, and therefore block the inhibitory function of PD-1 ligands on PD-1 expressing T cells. The antibodies of disclosure provide very potent agents for the treatment of multiple cancers via modulating human immune function.

Abstract: Provided are anti-CD40 agonistic antibodies, the nucleic acid molecules encoding the anti-CD40 antibodies, expression vectors and host cells used for the expression of anti-CD40 antibodies. Further provided are the methods for validating the function of antibodies in vitro and the efficacy of antibodies in vivo. The antibodies provide a very potent agent for the treatment of cancers via modulating immune functions.

Abstract: A point-to-multipoint data transmission method and device, the method including a left earbud and a right earbud of a true wireless stereo (TWS) headset separately performing pairing and service content negotiation with an electronic device. The left earbud receives left configuration information sent by the electronic device, to configure a left ISO channel, and the right earbud receives right configuration information sent by the electronic device, to configure a right ISO channel. The left earbud receives, based on the BLE-based audio profile, audio data that is sent by the electronic device through the left ISO channel, and the right earbud receives, based on the BLE-based audio profile, the audio data that is sent by the electronic device through the right ISO channel. The left earbud and the right earbud play the respectively received audio data based on a first timestamp.

Abstract: Provided are novel fully human monoclonal antibodies that bind to human LAG-3. It also provides the methods of hybridoma generation using humanized rats, the nucleic acid molecules encoding the anti-LAG-3 antibodies, expression vectors and host cells used for the expression of anti-LAG-3 antibodies. The invention further provides the methods for validating the function of antibodies in vitro. The antibodies of invention provide a potent agent for the treatment of multiple cancers via modulating human immune function.

Abstract: An audio data transmission method. An electronic device transmits audio data to a first earbud of a TWS headset by using a first CIS of a first CIG, and transmits audio data to a second earbud of the TWS headset by using a second CIS of the first CIG. The electronic device determines that the TWS headset is switched from a double-earbud mode (namely, a mode in which the first earbud and the second earbud are used together as audio input/output devices of the electronic device) to a first single-earbud mode (namely, a mode in which the first earbud is independently used as an audio input/output device of the electronic device). In response to the determining, the electronic device deactivates the second CIS, stops transmitting audio data to the second earbud by using the second CIS, and continues transmitting audio data to the first earbud by using the first CIS.

Abstract: Embodiments of this application disclose a method and a system for switching a sound channel of a headset, and a headset terminal, to accurately identify and determine a left-ear wearing status and a right-ear wearing status of a headset terminal, and accurately send a left-channel input audio signal and a right-channel input audio signal. A user does not need to manually switch a left channel and a right channel of the headset terminal. This greatly improves convenience of using the headset terminal.

Abstract: Provided are a warehousing management system and method. The system includes: a control server, an inventory container, an access device, a temporary container, a workstation and a carrying device. The control server is configured to, in response to a current task, determine a first target inventory container in which a target storage container hit by the current task is located, a first target access device, a target temporary container, a target workstation, and a first target carrying device, and control the first target access device to take out the target storage container from the first target inventory container, carry and store the target storage container to the target temporary container; and control the first target carrying device to move the target temporary container to the target workstation for operation.

Abstract: An earphone and a mobile terminal is provided, in which the earphone includes a housing and a speaker assembly. The housing internally includes a front cavity and a rear cavity that are separated by the speaker assembly. The front cavity is located on a side that is of the speaker assembly and that is a sound output direction, and the rear cavity is located on an opposite side of the sound output direction of the speaker assembly. One or more sound guide channels are disposed in the housing, each sound guide channel is disposed in a sidewall of the housing, and each sound guide channel is configured to: when the earphone is normally worn, connect air inside an ear canal of a user to air outside the ear canal without connecting air in the front cavity to air in the rear cavity.

Abstract: An electronic device establishes a first Bluetooth connection to a first wireless earbud, where there is a wireless connection between the first wireless earbud and a second wireless earbud. The electronic device establishes a second Bluetooth connection to the second wireless earbud by using the first wireless earbud. The electronic device simultaneously maintains the first Bluetooth connection and the second Bluetooth connection.

Abstract: A computer-implemented method comprises initializing a plurality of segment lists. Each segment list of the plurality of segment lists corresponds to a respective one of a plurality of disk drives. Each segment list divides storage space of the respective disk drive into a plurality of segments. The method further comprises, for each of the plurality of disk drives, identifying one or more candidate segments from the plurality of segments; calculating a respective segment distance variance for one or more combinations of identified candidate segments. Each combination of identified candidate segments includes one candidate segment for each of the plurality of disk drives. The method further comprises selecting a combination of the one or more combinations of identified candidate segments having the smallest respective segment distance variance; and storing data on the plurality of disk drives according to the selected combination of identified candidate segments.