Patents by Inventor Yongbo Hu

Yongbo Hu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10960812
    Abstract: A fully transparent luggage rack having a color illuminant includes a transparent longitudinal rod, an illuminant, a mounting base, a wire and a hollow bolt. The longitudinal rod is connected to the mounting base; the illuminant is arranged in the longitudinal rod; the mounting base is also fixed to a vehicle roof by means of the hollow bolt; and the wire penetrates the hollow bolt and is connected to the illuminant. A vehicle which is arranged with the fully transparent luggage rack having the color illuminant may be provided.
    Type: Grant
    Filed: December 13, 2019
    Date of Patent: March 30, 2021
    Assignee: WINBO-DONGJIAN AUTOMOTIVE TECHNOLOGY CO., LTD.
    Inventors: Yongbo Chen, Zhihai Zhang, Wei Hu, Wenxiang He, Jie Yang, Weiting He
  • Publication number: 20210015915
    Abstract: The present disclosure provides novel compounds of Formula (I) below. Compounds of the disclosure act as STING modulators/agonists. The present disclosure further relates to methods of synthesis of compounds of Formula (I) and methods of using of compounds of Formula (I) for the prophylaxis or treatment of cancer and other STING-related diseases. The compounds have the structure represented by Formula (I): wherein each symbol is as defined in the description, or a pharmaceutically acceptable salt thereof.
    Type: Application
    Filed: March 22, 2019
    Publication date: January 21, 2021
    Applicant: Takeda Pharmaceutical Company Limited
    Inventors: Jeffrey CIAVARRI, Dylan Bradley ENGLAND, Kenneth M. GIGSTAD, Alexandra E. GOULD, Paul GREENSPAN, Yongbo HU, Shi-Chung HUANG, Steven Paul LANGSTON, Hirotake MIZUTANI, Zhan SHI, Stepan VYSKOCIL, He XU
  • Publication number: 20200114808
    Abstract: A fully transparent luggage rack having a color illuminant includes a transparent longitudinal rod, an illuminant, a mounting base, a wire and a hollow bolt. The longitudinal rod is connected to the mounting base; the illuminant is arranged in the longitudinal rod; the mounting base is also fixed to a vehicle roof by means of the hollow bolt; and the wire penetrates the hollow bolt and is connected to the illuminant. A vehicle which is arranged with the fully transparent luggage rack having the color illuminant may be provided.
    Type: Application
    Filed: December 13, 2019
    Publication date: April 16, 2020
    Inventors: Yongbo Chen, Zhihai Zhang, Wei Hu, Wenxiang He, Jie Yang, Weiting He
  • Publication number: 20200114829
    Abstract: A roof luggage rack, a roof luggage rack assembly, and a vehicle having a roof luggage rack are provided. The roof luggage rack includes a body portion, defining a receiving chamber, and an illuminator, arranged in the receiving chamber. According to present the roof luggage rack, a lighting effect is provided to illuminate a side of the vehicle. A driver can observe a traffic condition or check articles carried on the luggage rack at night. Further, the luggage rack may have a dazzling lighting effect, and the vehicle may have an aesthetic appearance.
    Type: Application
    Filed: December 16, 2019
    Publication date: April 16, 2020
    Inventors: YONGBO CHEN, Zhihai Zhang, Wei Hu, Wenxiang He, Jie Yang, Weiting He
  • Publication number: 20200114809
    Abstract: A luggage rack able to illuminate includes a body portion (101), fixed on a top of a vehicle. A plurality of illuminators (103) is further included and arranged with the illuminating luggage rack. By arranging the illuminators (103), surrounding vehicles and drivers may easily notice the vehicle having the illuminating luggage rack, ensuring driving safety.
    Type: Application
    Filed: December 13, 2019
    Publication date: April 16, 2020
    Inventors: YONGBO CHEN, ZHIHAI ZHANG, WEI HU, WENXIANG HE, JIE YANG, WEITING HE
  • Patent number: 10538533
    Abstract: The present invention provides a compound of formula I: and pharmaceutically acceptable salts thereof, wherein X, R1, R2, R3, R4, R5, L1, L2, m, and n, are as described in the specification. Such compounds are inhibitors of VPS34 and thus useful for treating proliferative, inflammatory, or cardiovascular disorders.
    Type: Grant
    Filed: August 1, 2017
    Date of Patent: January 21, 2020
    Assignee: Millennium Pharmaceuticals, Inc.
    Inventors: Indu T. Bharathan, Chris Blackburn, Jeffrey P. Ciavarri, Jouhara Chouitar, Courtney A. Cullis, Natalie D'Amore, Paul E. Fleming, Kenneth M. Gigstad, Krista E. Gipson, Mario Girard, Yongbo Hu, Janice Lee, Gang Li, Mansoureh Rezaei, Michael D. Sintchak, Francois Soucy, Stephen G. Stroud, Tricia J. Vos, Tzu-Tshin Wong, He Xu, Tianlin Xu, Yingchun Ye
  • Publication number: 20200001797
    Abstract: The present disclosure provides a roof luggage rack and an article separation device. When used as the roof luggage rack, the device may include a cross rod assembly to carry articles; a longitudinal rod to fix on a vehicle roof; a locking buckle, which has two ends respectively buckling with the cross rod assembly and the longitudinal rod in a detachable manner, such that the cross rod assembly and the longitudinal rod may be fixed in a detachable manner. The roof luggage rack and the article separation device may be combined and connected by different means to achieve various purposes, overcoming a problem of the device having a single usage purpose.
    Type: Application
    Filed: September 12, 2019
    Publication date: January 2, 2020
    Inventors: Yongbo CHEN, Zhihai ZHANG, Wei HU, Jie YANG
  • Patent number: 10450324
    Abstract: In general, the present invention features improved methods useful for the synthesis of analogs of halichondrin B, such as eribulin and pharmaceutically acceptable salts thereof (e.g., eribulin mesylate).
    Type: Grant
    Filed: July 10, 2018
    Date of Patent: October 22, 2019
    Assignee: EISAI R&D MANAGEMENT CO., LTD.
    Inventors: Yongbo Hu, Huiming Zhang, Hiroyuki Chiba, Yuki Komatsu, Bryan M. Lewis
  • Publication number: 20190154714
    Abstract: A device for separating a reagent from a reactor includes a collecting means, provided with a liquid receiving port and a solid receiving port, a holding component disposed above the collecting means and used for placing the reactor, and a rotating mechanism for driving the holding component to rotate. The liquid receiving port and the solid receiving port are arranged at different positions in the circumferential direction of rotation of the holding component, when the holding component passes over the liquid receiving port, reagent in the reactor falls into the liquid receiving port, when the rotating mechanism continues rotating in the original direction until the holding component passes over the solid receiving port, the reactor falls into the solid receiving port from the holding component.
    Type: Application
    Filed: June 30, 2016
    Publication date: May 23, 2019
    Inventors: Kunhui HU, Yujin XIAO, Fuxing ZHANG, Benqing WU, Yongbo SONG
  • Patent number: 10202373
    Abstract: The present invention provides a compound of formula I: wherein R1, X1, X2, R2, R3, R4, R5, n, and m are as described in the specification. Such compounds are inhibitors of VPS34 and thus useful for treating proliferative, inflammatory, or cardiovascular disorders.
    Type: Grant
    Filed: January 13, 2015
    Date of Patent: February 12, 2019
    Assignee: MILLENNIUM PHARMACEUTICALS, INC.
    Inventors: Indu T. Bharathan, Chris Blackburn, Jeffrey P. Ciavarri, Jouhara Chouitar, Courtney A. Cullis, Natalie D'Amore, Paul E. Fleming, Kenneth M. Gigstad, Krista E. Gipson, Mario Girard, Yongbo Hu, Janice Lee, Gang Li, Mansoureh Rezaei, Michael D. Sintchak, Francois Soucy, Stephen G. Stroud, Tricia J. Vos, He Xu, Yingchun Ye
  • Publication number: 20190010166
    Abstract: In general, the present invention features improved methods useful for the synthesis of analogs of halichondrin B, such as eribulin and pharmaceutically acceptable salts thereof (e.g., eribulin mesylate).
    Type: Application
    Filed: July 10, 2018
    Publication date: January 10, 2019
    Inventors: Yongbo HU, Huiming ZHANG, Hiroyuki CHIBA, Yuki KOMATSU, Bryan M. LEWIS
  • Patent number: 10144742
    Abstract: This invention provides compounds of formula I and subsets thereof: wherein T, J, R, R4, Rq, o, RA, and RB and subsets thereof are as described in the specification. The compounds are inhibitors of NAMPT and are thus useful for treating cancer, inflammatory conditions, or T-cell mediated autoimmune disease.
    Type: Grant
    Filed: April 17, 2015
    Date of Patent: December 4, 2018
    Assignee: Millennium Pharmaceuticals, Inc.
    Inventors: Kenneth M. Gigstad, David P. Cardin, Takaharu Hirayama, Masaaki Hirose, Yongbo Hu, Hiroyuki Kakei, Hong Myung Lee, Takashi Motoyaji, Noriyuki Nii, Zhan Shi, Stepan Vyskocil, Hiroyuki Watanabe
  • Patent number: 10030032
    Abstract: In general, the present invention features improved methods useful for the synthesis of analogs of halichondrin B, such as eribulin and pharmaceutically acceptable salts thereof (e.g., eribulin mesylate).
    Type: Grant
    Filed: June 30, 2017
    Date of Patent: July 24, 2018
    Assignee: EISAI R&D MANAGEMENT CO., LTD.
    Inventors: Yongbo Hu, Huiming Zhang, Hiroyuki Chiba, Yuki Komatsu, Bryan M. Lewis
  • Publication number: 20180118762
    Abstract: The present invention provides a compound of formula I: and pharmaceutically acceptable salts thereof, wherein X, R1, R2, R3, R4, R5, L1, L2, m, and n, are as described in the specification. Such compounds are inhibitors of VPS34 and thus useful for treating proliferative, inflammatory, or cardiovascular disorders.
    Type: Application
    Filed: August 1, 2017
    Publication date: May 3, 2018
    Inventors: Indu T. BHARATHAN, Chris BLACKBURN, Jeffrey P. CIAVARRI, Jouhara CHOUITAR, Courtney A. CULLIS, Natalie D'AMORE, Paul E. FLEMING, Kenneth M. GIGSTAD, Krista E. GIPSON, Mario GIRARD, Yongbo HU, Janice LEE, Gang LI, Mansoureh REZAEI, Michael D. SINTCHAK, Francois SOUCY, Stephen G. STROUD, Tricia J. VOS, Tzu-Tshin WONG, He XU, Tianlin XU, Yingchun YE
  • Patent number: 9802960
    Abstract: The present invention provides a compound of formula I: and pharmaceutically acceptable salts thereof, wherein X, R1, R2, R3, R4, R5, L1, L2, m, and n, are as described in the specification. Such compounds are inhibitors of VPS34 and thus useful for treating proliferative, inflammatory, or cardiovascular disorders.
    Type: Grant
    Filed: January 13, 2015
    Date of Patent: October 31, 2017
    Assignee: Millennium Pharmaceuticals, Inc.
    Inventors: Indu T. Bharathan, Chris Blackburn, Jeffrey P. Ciavarri, Jouhara Chouitar, Courtney A. Cullis, Natalie D'Amore, Paul E. Fleming, Kenneth M. Gigstad, Krista E. Gipson, Mario Girard, Yongbo Hu, Janice Lee, Gang Li, Mansoureh Rezaei, Michael D. Sintchak, Francois Soucy, Stephen G. Stroud, Tricia J. Vos, Tzu-Tshin Wong, He Xu, Tianlin Xu, Yingchun Ye
  • Publication number: 20170298078
    Abstract: In general, the present invention features improved methods useful for the synthesis of analogs of halichondrin B, such as eribulin and pharmaceutically acceptable salts thereof (e.g., eribulin mesylate).
    Type: Application
    Filed: June 30, 2017
    Publication date: October 19, 2017
    Inventors: Yongbo HU, Huiming ZHANG, Hiroyuki CHIBA, Yuki KOMATSU, Bryan M. LEWIS
  • Patent number: 9751854
    Abstract: The present invention provides a compound of formula I: and pharmaceutically acceptable salts thereof, wherein X, R1, R2, R3, R4, R5, L1, L2, m, and n, are as described in the specification. Such compounds are inhibitors of VPS34 and thus useful for treating proliferative, inflammatory, or cardiovascular disorders.
    Type: Grant
    Filed: November 9, 2016
    Date of Patent: September 5, 2017
    Assignee: Millennium Pharmaceuticals, Inc.
    Inventors: Indu T. Bharathan, Chris Blackburn, Jeffrey P. Ciavarri, Jouhara Chouitar, Courtney A. Cullis, Natalie D'Amore, Paul E. Fleming, Kenneth M. Gigstad, Krista E. Gipson, Mario Girard, Yongbo Hu, Janice Lee, Gang Li, Mansoureh Rezaei, Michael D. Sintchak, Francois Soucy, Stephen G. Stroud, Tricia J. Vos, Tzu-Tshin Wong, He Xu, Tianlin Xu, Yingchun Ye
  • Patent number: 9695188
    Abstract: In general, the present invention features improved methods useful for the synthesis of analogs of halichondrin B, such as eribulin and pharmaceutically acceptable salts thereof (e.g., eribulin mesylate).
    Type: Grant
    Filed: March 3, 2016
    Date of Patent: July 4, 2017
    Assignee: EISAI R&D MANAGEMENT CO., LTD.
    Inventors: Yongbo Hu, Huiming Zhang, Hiroyuki Chiba, Yuki Komatsu, Bryan M. Lewis
  • Publication number: 20170174704
    Abstract: This invention provides compounds of formula I and subsets thereof: wherein T, J, R, R4, Rq, o, RA, and RB and subsets thereof are as described in the specification. The compounds are inhibitors of NAMPT and are thus useful for treating cancer, inflammatory conditions, or T-cell mediated autoimmune disease.
    Type: Application
    Filed: April 17, 2015
    Publication date: June 22, 2017
    Applicant: Millennium Pharmaceuticals, Inc.
    Inventors: Kenneth M. Gigstad, David P. Cardin, Takaharu Hirayama, Masaaki Hirose, Yongbo Hu, Hiroyuki Kakei, Hong Myung Lee, Takashi Motoyaji, Noriyuki Nii, Zhan Shi, Stepan Vyskocil, Hiroyuki Watanabe
  • Patent number: RE47797
    Abstract: Intermediates and methods of their use in the synthesis of analogs of halichondrin B are provided.
    Type: Grant
    Filed: April 3, 2018
    Date of Patent: January 7, 2020
    Assignee: EISAI R&D MANAGEMENT CO., LTD.
    Inventors: Farid Benayoud, Trevor Lee Calkins, Charles E. Chase, William Christ, Bryan M. Lewis, Matthew Schnaderbeck, Marc Pesant, Brian Austad, Silvio Campagna, Yongbo Hu, Gordon Wilkie, Xiaojie Zhu, Francis G. Fang