Patents by Inventor Yongbo Hu

Yongbo Hu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • HETEROARYLS AND USES THEREOF
    Publication number: 20160333007
    Abstract: The present invention provides a compound of formula I: wherein R1, X1, X2, R2, R3, R4, R5, n, and m are as described in the specification. Such compounds are inhibitors of VPS34 and thus useful for treating proliferative, inflammatory, or cardiovascular disorders.
    Type: Application
    Filed: January 13, 2015
    Publication date: November 17, 2016
    Inventors: INDU T. BHARATHAN, Chris BLACKBURN, Jeffrey P. CIAVARRI, Jouhara CHOUITAR, Courtney A. CILLIS, Natalie D'AMORE, Paul E. FLE,OMG, Kenneth M. GIGSTAD, Kirsta E. GIPSON, Mario GIRARD, Yongbo HU, Janice LEE, Gang LI, Mansoureh REZAEI, Michael D. SINTCHAK, Francois SOUCY, Stephen g. STROUD, Tricia J. VOS, He XU, Yingchun YE
  • Halichondrin B analogs
    Patent number: 9469651
    Abstract: The invention includes halichondrin B analogs having pharmaceutical activity; in some cases, crystalline forms thereof, and in some cases, halichondrin B analogs having a further utility as synthetic intermediates.
    Type: Grant
    Filed: May 8, 2015
    Date of Patent: October 18, 2016
    Assignee: Eisai R&D Management Co., Ltd.
    Inventor: Yongbo Hu
  • METHODS USEFUL IN THE SYNTHESIS OF HALICHONDRIN B ANALOGS
    Publication number: 20160176895
    Abstract: In general, the present invention features improved methods useful for the synthesis of analogs of halichondrin B, such as eribulin and pharmaceutically acceptable salts thereof (e.g., eribulin mesylate).
    Type: Application
    Filed: March 3, 2016
    Publication date: June 23, 2016
    Inventors: Yongbo HU, Huiming ZHANG, Hiroyuki CHIBA, Yuki KOMATSU, Bryan M. LEWIS
  • Halichondrin B analogs
    Patent number: 9206194
    Abstract: The invention includes halichondrin B analogs having pharmaceutical activity; in some cases, crystalline forms thereof, and in some cases, halichondrin B analogs having a further utility as synthetic intermediate.
    Type: Grant
    Filed: October 21, 2013
    Date of Patent: December 8, 2015
    Assignee: Eisai R&D Management Co., Ltd.
    Inventor: Yongbo Hu
  • HALICHONDRIN B ANALOGS
    Publication number: 20150315206
    Abstract: The invention includes halichondrin B analogs having pharmaceutical activity; in some cases, crystalline forms thereof, and in some cases, halichondrin B analogs having a further utility as synthetic intermediates.
    Type: Application
    Filed: May 8, 2015
    Publication date: November 5, 2015
    Inventor: Yongbo HU
  • HETEROARYLS AND USES THEREOF
    Publication number: 20150225422
    Abstract: The present invention provides a compound of formula I: and pharmaceutically acceptable salts thereof, wherein X, R1, R2, R3, R4, R5, L1, L2, m, and n, are as described in the specification. Such compounds are inhibitors of VPS34 and thus useful for treating proliferative, inflammatory, or cardiovascular disorders.
    Type: Application
    Filed: January 13, 2015
    Publication date: August 13, 2015
    Inventors: Indu T. Bharathan, Chris Blackburn, Jeffrey P. Ciavarri, Jouhara Chouitar, Courtney A. Cullis, Natalie D'Amore, Paul E. Fleming, Kenneth M. Gigstad, Krista E. Gipson, Mario Girard, Yongbo Hu, Janice Lee, Gang Li, Mansoureh Rezaei, Michael D. Sintchak, Francois Soucy, Stephen G. Stroud, Tricia J. Vos, Tzu-Tshin Wong, He Xu, Tianlin Xu, Yingchun Ye
  • HETEROARYLS AND USES THEREOF
    Publication number: 20150175563
    Abstract: This invention provides compounds of formula IA-i-a or IB-i-a and subsets thereof: wherein Z, HY, R1, R2, R3, G1, W, n, and A and subsets thereof are as described in the specification. The compounds are inhibitors of PI3K and are thus useful for treating proliferative, inflammatory, or cardiovascular disorders.
    Type: Application
    Filed: July 29, 2014
    Publication date: June 25, 2015
    Inventors: Brian S. Freeze, Masaaki Hirose, Yongbo Hu, Todd B. Sells, Zhan Shi, Stepan Vyskocil, Tianlin Xu
  • HETEROARYLS AND USES THEREOF
    Publication number: 20150175593
    Abstract: This invention provides compounds of formula IA-a or IB-a and subsets thereof: wherein Z, HY, R1, R2, G1, W, n, and A and subsets thereof are as described in the specification. The compounds are inhibitors of PI3K and are thus useful for treating proliferative, inflammatory, or cardiovascular disorders.
    Type: Application
    Filed: July 29, 2014
    Publication date: June 25, 2015
    Inventors: Masaaki Hirose, Zhigen Hu, Yongbo Hu, Hong Myung Lee, Zhan Shi, Stepan Vyskocil, Tianlin Xu
  • Heteroaryls and uses thereof
    Patent number: 9062038
    Abstract: This invention provides compounds of formula IA or IB: wherein HY, R1, R2, G1, W, n, and A are as described in the specification. The compounds are inhibitors of PI3K and/or mTor and are thus useful for treating proliferative, inflammatory, or cardiovascular disorders.
    Type: Grant
    Filed: August 10, 2011
    Date of Patent: June 23, 2015
    Assignee: Millennium Pharmaceuticals, Inc.
    Inventors: Masaaki Hirose, Yongbo Hu, Zhigen Hu, Hong Myung Lee, Zhan Shi, Stepan Vyskocil, Tianlin Xu
  • METHODS USEFUL IN THE SYNTHESIS OF HALICHONDRIN B ANALOGS
    Publication number: 20150158881
    Abstract: In general, the present invention features improved methods useful for the synthesis of analogs of halichondrin B, such as eribulin and pharmaceutically acceptable salts thereof (e.g., eribulin mesylate).
    Type: Application
    Filed: December 5, 2014
    Publication date: June 11, 2015
    Inventors: Yongbo HU, Huiming ZHANG, Hiroyuki CHIBA, Yuki KOMATSU, Bryan M. LEWIS
  • Halichondrin B analogs
    Patent number: 9029573
    Abstract: The invention includes halichondrin B analogs having pharmaceutical activity; in some cases, crystalline forms thereof, and in some cases, halichondrin B analogs having a further utility as synthetic intermediate.
    Type: Grant
    Filed: October 21, 2013
    Date of Patent: May 12, 2015
    Assignee: Eisai R&D Management Co., Ltd.
    Inventor: Yongbo Hu
  • Heteroaryls and uses thereof
    Patent number: 8796268
    Abstract: This invention provides compounds of formula IA-i-a or IB-i-a and subsets thereof: wherein Z, HY, R1, R2, R3, G1, W, n, and A and subsets thereof are as described in the specification. The compounds are inhibitors of PI3K and are thus useful for treating proliferative, inflammatory, or cardiovascular disorders.
    Type: Grant
    Filed: August 11, 2011
    Date of Patent: August 5, 2014
    Assignee: Millennium Pharmaceuticals, Inc.
    Inventors: Brian S. Freeze, Masaaki Hirose, Yongbo Hu, Todd B. Sells, Zhan Shi, Stepan Vyskocil, Tianlin Xu
  • Heteroaryls and uses thereof
    Patent number: 8796271
    Abstract: This invention provides compounds of formula IA-a or IB-a and subsets thereof: wherein Z, HY, R1, R2, G1, W, n, and A and subsets thereof are as described in the specification. The compounds are inhibitors of PI3K and are thus useful for treating proliferative, inflammatory, or cardiovascular disorders.
    Type: Grant
    Filed: August 11, 2011
    Date of Patent: August 5, 2014
    Assignee: Millennium Pharmaceuticals, Inc.
    Inventors: Masaaki Hirose, Zhigen Hu, Yongbo Hu, Hong Myung Lee, Zhan Shi, Stepan Vyskocil, Tianlin Xu
  • HALICHONDRIN B ANALOGS
    Publication number: 20140163244
    Abstract: The invention includes halichondrin B analogs having pharmaceutical activity; in some cases, crystalline forms thereof, and in some cases, halichondrin B analogs having a further utility as synthetic intermediate.
    Type: Application
    Filed: October 21, 2013
    Publication date: June 12, 2014
    Applicant: Eisai R&D Management Co., Ltd.
    Inventor: Yongbo HU
  • Halichondrin B analogs
    Patent number: 8598373
    Abstract: The invention includes halichondrin B analogs having pharmaceutical activity; in some cases, crystalline forms thereof, and in some cases, halichondrin B analogs having a further utility as synthetic intermediates.
    Type: Grant
    Filed: April 3, 2009
    Date of Patent: December 3, 2013
    Assignee: Eisai R&D Management Co., Ltd.
    Inventor: Yongbo Hu
  • HETEROARYLS AND USES THEREOF
    Publication number: 20130267563
    Abstract: This invention provides compounds of formula IA or IB: wherein HY, R1, R2, G1, W, n, and A are as described in the specification. The compounds are inhibitors of PI3K and/or mTor and are thus useful for treating proliferative, inflammatory, or cardiovascular disorders.
    Type: Application
    Filed: August 10, 2011
    Publication date: October 10, 2013
    Applicant: Millennium Pharmaceuticals, Inc.
    Inventors: Masaaki Hirose, Yongbo Hu, Zhigen Hu, Hong Myung Lee, Zhan Shi, Stephan Vyskocil, Tianlin Xu
  • HETEROARYLS AND USES THEREOF
    Publication number: 20120178723
    Abstract: This invention provides compounds of formula IA-a or IB-a and subsets thereof: wherein Z, HY, R1, R2, G1, W, n, and A and subsets thereof are as described in the specification. The compounds are inhibitors of PI3K and are thus useful for treating proliferative, inflammatory, or cardiovascular disorders.
    Type: Application
    Filed: August 11, 2011
    Publication date: July 12, 2012
    Applicant: Millennium Pharmaceuticals, Inc.
    Inventors: Masaaki Hirose, Zhigen Hu, Yongbo Hu, Hong Myung Lee, Zhan Shi, Stepan Vyskocil, Tianlin Xu
  • HETEROARYLS AND USES THEREOF
    Publication number: 20120172345
    Abstract: This invention provides compounds of formula IA-i-a or IB-i-a and subsets thereof: wherein Z, HY, R1, R2, R3, G1, W, n, and A and subsets thereof are as described in the specification. The compounds are inhibitors of PI3K and are thus useful for treating proliferative, inflammatory, or cardiovascular disorders.
    Type: Application
    Filed: August 11, 2011
    Publication date: July 5, 2012
    Applicant: Millennium Pharmaceuticals, Inc.
    Inventors: Brian S. Freeze, Masaaki Hirose, Yongbo Hu, Todd B. Sells, Zhan Shi, Stepan Vyskocil, Tianlin Xu
  • INTERMEDIATES FOR THE PREPARATION OF ANALOGS OF HALICHONDRIN B
    Publication number: 20120029213
    Abstract: Intermediates and methods of their use in the synthesis of analogs of halichondrin B are provided.
    Type: Application
    Filed: June 29, 2011
    Publication date: February 2, 2012
    Applicant: Eisai R&D Management Co., Ltd.
    Inventors: Brian Austad, Farid Benayoud, Trevor Calkins, Silvio Campagna, Charles E. Chase, William Christ, Francis G. Fang, Yongbo Hu, Bryan M. Lewis, Marc Pesant, Matthew Schnaderbeck, Gordon Wilkie, Xiaojie Zhu
  • PROCESS FOR PREPARING CERTAIN CINNAMIDE COMPOUNDS
    Publication number: 20110172427
    Abstract: This invention relates to a new synthesis, intermediates and precursors leading to a mixture of the compounds 11 and 12 as shown below. It also relates to the resolution of the stereoisomeric mixture to provide in substantial stereochemical purity compound 12. The synthesis of the invention involves preparation of compound 7 and compound 10 as shown below and their reaction to prepare a mixture of compound 11 and compound 12.
    Type: Application
    Filed: August 26, 2009
    Publication date: July 14, 2011
    Applicant: EISAI R&D MANAGEMENT CO., LTD.
    Inventors: Taiju Nakamura, Masaaki Matsuda, Yongbo Hu, Daiju Hasegawa, Yorihisa Hoshino, Kazato Inanaga, Minetaka Isomura, Nobuaki Sato, Kazuhiro Yoshizawa, George A. Moniz, Gordon D. Wilkie, Francis G. Fang, Yoshihiro Nishikawa