Patents by Inventor Yongbo Hu

Yongbo Hu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Halichondrin B Analogs
    Publication number: 20110054194
    Abstract: The invention includes halichondrin B analogs having pharmaceutical activity; in some cases, crystalline forms thereof, and in some cases, halichondrin B analogs having a further utility as synthetic intermediates.
    Type: Application
    Filed: April 3, 2009
    Publication date: March 3, 2011
    Applicant: Eisai R&D Management Co., Ltd.
    Inventor: Yongbo Hu
  • Anilino-pyrimidine analogs
    Patent number: 7799915
    Abstract: The present invention relates to compounds of formula I: wherein R1, R2, R3, R4, R5, and R6 are defined herein.
    Type: Grant
    Filed: October 13, 2005
    Date of Patent: September 21, 2010
    Assignee: Wyeth LLC
    Inventors: Fuk-Wah Sum, Dennis William Powell, Yixian Zhang, Lijing Chen, Scott Lee Kincaid, Lee Dalton Jennings, Yongbo Hu, Adam Matthew Gilbert, Matthew Gregory Bursavich
  • Signal-1/signal-2 bifunctional peptide inhibitors
    Patent number: 7786257
    Abstract: A novel peptide sequence having the general formula AB wherein each of A and B represent a chain of amino acid residues and wherein said A chain is capable of binding with a major histocompatibility complex on an antigen presenting cell, and wherein said B chain is capable of binding with a Signal-2 receptor on an antigen presenting cell. Preferred forms of the peptide sequence further include an X chain positioned intermediate the A chain and the B chain. Moreover, preferred forms include an A chain which has at least about 10% sequence homology with a Signal-1 moiety, or is a peptidomimetic of a Signal-1 moiety, said B chain has at least 10% sequence homology with a Signal-2 receptor moiety, or is a peptidomimetic of a Signal-2 receptor moiety, and wherein the X chain has at least one amino acid residue, or is a peptidomimetic of that amino acid residue.
    Type: Grant
    Filed: December 18, 2000
    Date of Patent: August 31, 2010
    Assignee: University of Kansas
    Inventors: Joseph S. Murray, Teruna J. Siahaan, Yongbo Hu
  • Benzo[C][2,7]Naphtyridine Derivatives, Methods of Making Thereof and Methods of Use Thereof
    Publication number: 20080293712
    Abstract: The present invention relates to Benzo[c][2,7]naphthyridine Derivatives, compositions comprising an effective amount of a Benzo[c][2,7]naphthyridine Derivative, methods for treating or preventing a proliferative disorder or an autoimmune disease, comprising administering to a subject in need thereof an effective amount of a Benzo[c][2,7]naphthyridine Derivative, methods for modulating PDK-1 activity, PKA activity, Akt activity, S6K activity, or PKC activity, comprising administering to a subject in need thereof an effective amount of a Benzo[c][2,7]naphthyridine Derivative. The invention also relates to processes for preparing a Benzo[c][2,7]naphthyridine Derivative.
    Type: Application
    Filed: March 4, 2008
    Publication date: November 27, 2008
    Applicant: WYETH
    Inventors: Allan WISSNER, Middleton Brawner FLOYD, JR., Russell DUSHIN, Heidi L. FRASER, Yongbo HU, Andreas MADERNA, Thomas NITTOLI, Yanong Daniel WANG
  • Anilino-pyrimidine phenyl and benzothiophene analogs
    Publication number: 20070244140
    Abstract: The present invention relates to compounds of formula III: wherein R2, R3, R5 and R6 are as defined herein.
    Type: Application
    Filed: April 10, 2007
    Publication date: October 18, 2007
    Applicant: Wyeth
    Inventors: Yongbo Hu, Fuk-Wah Sum, Martin Di Grandi, Emily Norton
  • Anilino-pyrimidine analogs
    Publication number: 20060079543
    Abstract: The present invention relates to compounds of formula I: wherein R1, R2, R3, R4, R5, and R6 are defined herein.
    Type: Application
    Filed: October 13, 2005
    Publication date: April 13, 2006
    Applicant: Wyeth
    Inventors: Fuk-Wah Sum, Dennis Powell, Yixian Zhang, Lijing Chen, Scott Kincaid, Lee Jennings, Yongbo Hu, Adam Gilbert, Matthew Bursavich
  • Signal-1/signal-2 bifunctional peptide inhibitors
    Publication number: 20050107585
    Abstract: A novel peptide sequence having the general formula AB wherein each of A and B represent a chain of amino acid residues and wherein said A chain is capable of binding with a major histocompatibility complex on an antigen presenting cell, and wherein said B chain is capable of binding with a Signal-2 receptor on an antigen presenting cell. Preferred forms of the peptide sequence further include an X chain positioned intermediate the A chain and the B chain. Moreover, preferred forms include an A chain which has at least about 10% sequence homology with a Signal-1 moiety, or is a peptidomimetic of a Signal-1 moiety, said B chain has at least 10% sequence homology with a Signal-2 receptor moiety, or is a peptidomimetic of a Signal-2 receptor moiety, and wherein the X chain has at least one amino acid residue, or is a peptidomimetic of that amino acid residue.
    Type: Application
    Filed: December 18, 2000
    Publication date: May 19, 2005
    Inventors: Joseph Murray, Teruna Siahaan, Yongbo Hu