Patents by Inventor Yoshinori Yoshida

Yoshinori Yoshida has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10067145
    Abstract: The present invention provides a method that allows highly efficient and highly reliable evaluation of genomic stability of pluripotent stem cells, a method for removing pluripotent stem cells that have been identified as genomically unstable by the evaluation method from a culture of pluripotent stem cells to be evaluated, and a synthetic peptide that can be used for the methods. The methods provided by the present invention include preparing a culture of pluripotent stem cells of interest and analyzing an expression level of calreticulin for the pluripotent stem cells in the culture followed by identifying genomic stability or genomic instability of the stem cells on the basis of the expression level of calreticulin.
    Type: Grant
    Filed: October 30, 2014
    Date of Patent: September 4, 2018
    Assignees: TOAGOSEI CO., LTD., KYOTO UNIVERSITY
    Inventors: Tetsuhiko Yoshida, Nahoko Baileykobayashi, Yoshinori Yoshida, Kazuhisa Chonabayashi
  • Publication number: 20180150063
    Abstract: A processing device that processes a lens, comprising a design data receiver that receives design data of the lens from an external section. Also included are a memory that stores the received design data, an input section that inputs authentication information which is embedded in or attached to the lens and is used in use permission of design data, and a controller that performs an authentication process whether or not the authentication information corresponds to the design data and controls whether or not a processing of the lens by using the design data is started.
    Type: Application
    Filed: December 15, 2017
    Publication date: May 31, 2018
    Inventors: Yoshinori Yoshida, Yukio Honma, Hideya Inoue, Koji Yamagaki
  • Publication number: 20180127727
    Abstract: Provided is a method for producing myocardial cells from pluripotent stem cells. The myocardial cell production method provided by the present invention includes supplying an artificially produced synthetic peptide to a cell culture that contains pluripotent stem cells. The synthetic peptide is a peptide that contains a myocardial cell differentiation-inducing peptide sequence that induces pluripotent stem cells into myocardial cells. The myocardial cell differentiation-inducing peptide sequence is an amino acid sequence selected from the group consisting of (i) an amino acid sequence constituting the signal peptide of any protein belonging to the amyloid precursor protein (APP) family, (ii) a partial amino acid sequence of the amino acid sequence according to (i), and (iii) a modified amino acid sequence from the amino acid sequence according to (i) or (ii).
    Type: Application
    Filed: April 28, 2016
    Publication date: May 10, 2018
    Applicants: Toagosei Co., Ltd., KYOTO UNIVERSITY
    Inventors: Tetsuhiko Yoshida, Kenichi Tanaka, Nahoko Baileykobayashi, Yoshinori Yoshida
  • Publication number: 20180100203
    Abstract: An object of the present invention is to provide a method for increasing the purity of a type of tissue cell such as an endothelial cell, a hepatocyte, or an insulin-producing cell. The present invention solves the problem by providing a method comprising a step of introducing, into a cell population, an mRNA comprising a nucleic acid sequence recognized by an miRNA specifically expressed in endothelial cells, hepatocytes, or insulin-producing cells.
    Type: Application
    Filed: April 22, 2016
    Publication date: April 12, 2018
    Inventors: Yoshinori Yoshida, Hirohide Saito, Kenji Miki, Kei Endo, Seiya Takahashi
  • Publication number: 20180038533
    Abstract: A pipe joint includes a hollow joint main body; a nut that is screwed into the joint main body; a seal member that is mounted to inside of the joint main body; and a retainer that is placed between the joint main body and the nut and comprises a pawl portion engaged with a trough of a metal flexible pipe in a coupled state and a retainer locking portion caught and locked inside of the joint main body in the coupled state.
    Type: Application
    Filed: February 19, 2016
    Publication date: February 8, 2018
    Inventors: Makoto Ibayashi, Yoshinori Yoshida, Takashi Toku, Takaaki Inotani
  • Patent number: 9886027
    Abstract: A lens processing management system includes a lens processing section that processes a lens based on design data, an authentication section that is substantially attached to a lens material or a semi-finished lens product, and an authentication processing section that performs an authentication process for the processing of the lens using the authentication section.
    Type: Grant
    Filed: August 24, 2012
    Date of Patent: February 6, 2018
    Assignees: NIKON-ESSILOR CO., LTD., NIKON CORPORATION
    Inventors: Yoshinori Yoshida, Yukio Honma, Hideya Inoue, Koji Yamagaki
  • Publication number: 20170369846
    Abstract: An object of the present invention is to provide a novel method for sorting cardiomyocytes. Another object of the present invention is to provide a method for producing high-purity cardiomyocytes and a kit used therefor. The present invention provides a method for sorting cardiomyocytes, comprising a step of introducing miRNA-responsive mRNA into a cell group, wherein the miRNA-responsive mRNA consists of a sequence comprising the following (i) and (ii): (i) a nucleic acid specifically recognized by miRNA specifically expressed in cardiomyocytes, and (ii) a nucleic acid corresponding to the coding region of a gene, wherein translation of (ii) the nucleic acid corresponding to the coding region of a gene into protein is regulated by the nucleic acid sequence in (i) above, thereby achieving the aforementioned objects.
    Type: Application
    Filed: March 20, 2015
    Publication date: December 28, 2017
    Inventors: Yoshinori Yoshida, Hirohide Saito, Kenji Miki, Kei Endo, Seiya Takahashi
  • Publication number: 20170349883
    Abstract: From a cell population containing cardiomyocytes, the cardiomyocytes are extracted using a marker(s) specific to cardiomyocytes, that is, at least one marker selected from CORIN, NCAM1, CRYAB, HBEGF, DMD, ATPIF1, CAV2, ITGAV, DCBLD2, CLIC4, BMPR2, CTSB, TMEM123, USP14, and MIR761.
    Type: Application
    Filed: December 24, 2015
    Publication date: December 7, 2017
    Inventors: Yoshinori Yoshida, Shunsuke Funakoshi
  • Publication number: 20170335285
    Abstract: The present invention provides a method for producing or detecting cardiomyocytes by extracting/detecting cardiomyocytes from a cell population which includes cardiomyocytes using, as an index, positivity of NCAM1, SSEA3, SSEA4 and/or CD340.
    Type: Application
    Filed: June 12, 2017
    Publication date: November 23, 2017
    Inventors: Shinya Yamanaka, Yoshinori Yoshida, Shunsuke Funakoshi
  • Patent number: 9822342
    Abstract: The present invention provides a method for efficiently producing cardiomyocytes from pluripotent stem cells, which method comprises the steps of dissociating embryoid bodies obtained during the production process, and allowing reaggregation of the resulting cells to allow formation of embryoid bodies.
    Type: Grant
    Filed: May 9, 2014
    Date of Patent: November 21, 2017
    Assignee: KYOTO UNIVERSITY
    Inventors: Shinya Yamanaka, Yoshinori Yoshida, Kenji Miki
  • Patent number: 9528092
    Abstract: Provided is a method of improving the efficiency of establishment of induced pluripotent stem cells, comprising culturing somatic cells under hypoxic conditions in the step of nuclear reprogramming thereof.
    Type: Grant
    Filed: July 30, 2009
    Date of Patent: December 27, 2016
    Assignee: Kyoto University
    Inventors: Shinya Yamanaka, Yoshinori Yoshida
  • Publication number: 20160318975
    Abstract: A method for promoting expression of calreticulin in at least one kind of eukaryotic cell, and a synthetic peptide useful in this method are provided. In the method provided by the present invention, a culture of target cells is prepared, and a calreticulin expression-promoting peptide having calreticulin expression-promoting activity is supplied at least once to that culture.
    Type: Application
    Filed: December 24, 2014
    Publication date: November 3, 2016
    Applicants: TOAGOSEI CO., LTD., KYOTO UNIVERSITY
    Inventors: Nahoko BAILEYKOBAYASHI, Tetsuhiko YOSHIDA, Yoshinori YOSHIDA, Kazuhisa CHONABAYASHI
  • Patent number: 9447408
    Abstract: The present invention provides a method of improving the efficiency of establishment of induced pluripotent stem (iPS) cells by inhibiting p38 function in the step of somatic cell nuclear reprogramming. The 38 function can be inhibited by bringing an inhibitor selected from the group consisting of (1) a chemical inhibitor of p38 (2) a dominant negative mutant of p38 or a nucleic acid that encodes the same, (3) a nucleic acid selected from the group consisting of siRNAs and shRNAs targeted to p38 and DNAs that encode the same and (4) an inhibitor of p38 pathway into contact with a somatic cell and the like.
    Type: Grant
    Filed: September 14, 2011
    Date of Patent: September 20, 2016
    Assignee: Kyoto University
    Inventors: Shinya Yamanaka, Yoshinori Yoshida, Hidaka Yokota
  • Publication number: 20160252523
    Abstract: The present invention provides a method that allows highly efficient and highly reliable evaluation of genomic stability of pluripotent stem cells, a method for removing pluripotent stem cells that have been identified as genomically unstable by the evaluation method from a culture of pluripotent stem cells to be evaluated, and a synthetic peptide that can be used for the methods. The methods provided by the present invention include preparing a culture of pluripotent stem cells of interest and analyzing an expression level of calreticulin for the pluripotent stem cells in the culture followed by identifying genomic stability or genomic instability of the stem cells on the basis of the expression level of calreticulin.
    Type: Application
    Filed: October 30, 2014
    Publication date: September 1, 2016
    Applicants: TOAGOSEI CO., LTD., KYOTO UNIVERSITY
    Inventors: Tetsuhiko YOSHIDA, Nahoko BAILEYKOBAYASHI, Yoshinori YOSHIDA, Kazuhisa CHONABAYASHI
  • Patent number: 9397160
    Abstract: Provided is a semiconductor device having improved performance. A semiconductor substrate is formed with unit LDMOSFET elements. The unit LDMOSFET elements have respective source regions electrically coupled to each other via a first source interconnect line and a second source interconnect line. The unit LDMOSFET elements have respective gate electrodes electrically coupled to each other via a first gate interconnect line and also electrically coupled to a second gate interconnect line in the same layer as that of the second source interconnect line via the first gate interconnect line. The unit LDMOSFET elements have respective drain regions electrically coupled to a back surface electrode via a conductive plug embedded in a trench of the semiconductor substrate. Each of the first source interconnect line and the first gate interconnect line has a thickness smaller than that of the second source interconnect line. Over the plug, the first gate interconnect line extends.
    Type: Grant
    Filed: September 3, 2015
    Date of Patent: July 19, 2016
    Assignee: RENESAS ELECTRONICS CORPORATION
    Inventors: Yoshinori Yoshida, Hirokazu Kato, Tsuyoshi Kachi, Keisuke Furuya
  • Publication number: 20160146788
    Abstract: The present invention provides a method of screening for a therapeutic or prophylactic drug for acute myeloid leukemia or myelodysplastic syndrome, comprising the following steps: (a) a step of forming colonies of hematopoietic progenitor cells induced from pluripotent stem (iPS) cells produced from non-T cells in blood mononuclear cells isolated from myelodysplastic syndrome patients, in the presence of a test substance and in the absence of the test substance, and (b) a step of selecting the test substance as a candidate for a therapeutic or prophylactic drug for acute myeloid leukemia or myelodysplastic syndrome and the like when the colony number in the presence of the test substance increases from the colony number in the absence of the test substance.
    Type: Application
    Filed: May 23, 2014
    Publication date: May 26, 2016
    Inventors: Shinya Yamanaka, Yoshinori Yoshida, Kazuhisa Chonabayashi
  • Publication number: 20160137981
    Abstract: A method for producing hematopoietic stem cells and/or hematopoietic progenitor cells from pluripotent stem cells is described. The method includes a step of culturing pluripotent stem cells in the presence of IGF2. A method is described for selecting an induced pluripotent stem cell(s) having high capacity to differentiate into hematopoietic stem cells and/or hematopoietic progenitor cells, or into blood cells, based on the expression level(s) of one or more genes such as TRIM58, CTSF, FAM19A5, and TCERG1L genes, or on the DNA methylation state(s) of the TRIM58, CSMD1, and/or FAM19A5 gene(s).
    Type: Application
    Filed: June 11, 2014
    Publication date: May 19, 2016
    Inventors: Shinya Yamanaka, Yoshinori Yoshida, Masatoshi Nishizawa
  • Publication number: 20160122716
    Abstract: The present invention provides a method for efficiently producing cardiomyocytes from pluripotent stem cells, which method comprises the steps of dissociating embryoid bodies obtained during the production process, and allowing reaggregation of the resulting cells to allow formation of embryoid bodies.
    Type: Application
    Filed: May 9, 2014
    Publication date: May 5, 2016
    Applicant: Kyoto University
    Inventors: Shinya Yamanaka, Yoshinori Yoshida, Kenji Miki
  • Patent number: 9311684
    Abstract: A lens processing management system (1) includes: a processing device (20) which processes lenses; a data supply device (10) which can supply design data to the processing device; and a control means (24) which limits the processing of lenses using the design data in the processing device.
    Type: Grant
    Filed: August 28, 2009
    Date of Patent: April 12, 2016
    Assignee: NIKON-ESSILOR CO., LTD.
    Inventors: Yoshinori Yoshida, Yukio Honma
  • Publication number: 20150380487
    Abstract: Provided is a semiconductor device having improved performance. A semiconductor substrate is formed with unit LDMOSFET elements. The unit LDMOSFET elements have respective source regions electrically coupled to each other via a first source interconnect line and a second source interconnect line. The unit LDMOSFET elements have respective gate electrodes electrically coupled to each other via a first gate interconnect line and also electrically coupled to a second gate interconnect line in the same layer as that of the second source interconnect line via the first gate interconnect line. The unit LDMOSFET elements have respective drain regions electrically coupled to a back surface electrode via a conductive plug embedded in a trench of the semiconductor substrate. Each of the first source interconnect line and the first gate interconnect line has a thickness smaller than that of the second source interconnect line. Over the plug, the first gate interconnect line extends.
    Type: Application
    Filed: September 3, 2015
    Publication date: December 31, 2015
    Inventors: Yoshinori Yoshida, Hirokazi Kato, Tsuyoshi Kachi, Keisuke Furuya