Patents by Inventor Yoshiyuki Fukase

Yoshiyuki Fukase has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Pyridinone- and pyridazinone-based compounds and uses thereof
    Patent number: 11964960
    Abstract: The various examples presented herein are directed to compounds of the formula A-L1-Het1-L2-Cy1 or a pharmaceutical acceptable salt, polymorph, prodrug, solvate or clathrate thereof, wherein: A is cycloalkyl, aryl, arylalkyl or heterocyclyl; Het1 is heterocyclyl containing at least two heteroatoms; Cy1 is a heterocyclyl; L1 is a bond, alkyl, alkenyl or alkynyl linker; L2 is an acyl or alkyl linker; and A and Cy1 are different. The compounds are useful in the treatment of fibrotic diseases, abnormal vascular leak and pathological angiogenesis.
    Type: Grant
    Filed: March 8, 2019
    Date of Patent: April 23, 2024
    Assignees: Cornell University, Tri-Institutional Therapeutics Discovery Institute
    Inventors: Timothy Hla, Irina Jilishitz, Peter Meinke, Andrew Stamford, Michael Foley, Ayumu Sato, Yasufimi Wada, Yoshiyuki Fukase, Asato Kina, Hiroki Takahagi, Hideyuki Igawa, William J. Polvino
  • Heterocyclic amide compounds having an RORvt inhibitory action
    Patent number: 11851449
    Abstract: The present invention relates to compound (I) or a salt thereof which has a ROR?t inhibitory action. In the formula (I), each symbol is as defined in the specification.
    Type: Grant
    Filed: May 10, 2021
    Date of Patent: December 26, 2023
    Assignee: TAKEDA PHARMACEUTICAL COMPANY LIMITED
    Inventors: Satoshi Yamamoto, Junya Shirai, Mitsunori Kono, Yoshihide Tomata, Ayumu Sato, Atsuko Ochida, Yoshiyuki Fukase, Shoji Fukumoto, Tsuneo Oda, Hidekazu Tokuhara, Naoki Ishii, Yusuke Sasaki
  • INHIBITORS OF ENL/AF9 YEATS
    Publication number: 20230027198
    Abstract: Methods and compositions for treating leukemia are disclosed. Acylated 6-aminoindoles, acylated 6-aminopyrrolopyridines and acylated 3-aminopyrrolo[3,2-c]pyridazines of the following formula inhibit ENL/AF9 YEATS and are therefore useful for treating leukemia.
    Type: Application
    Filed: December 17, 2020
    Publication date: January 26, 2023
    Inventors: Tanweer A. KHAN, Nigel LIVERTON, Yoshiyuki FUKASE, Mayako MICHINO, Andrew W. STAMFORD, Michael W. MILLER, David HUGGINS, Peter MEINKE, David C. ALLIS, Liling WAN, Tammy LADDUWAHETTY, Joseph VACCA
  • Pyrazoloquinazolinone antitumor agents
    Patent number: 11192893
    Abstract: Compounds of formula: are useful as antitumor agents. In these compounds, R10 is (a) (C1-C10) hydrocarbyl, (C1-C10)halohydrocarbyl, (C1-C6)hydroxyalkyl, or or R10 is (b) in which Q and A are linkers and Ar is optionally substituted monocyclic or bicyclic aryl or heteroaryl.
    Type: Grant
    Filed: May 18, 2018
    Date of Patent: December 7, 2021
    Assignee: The Rockefeller University
    Inventors: Tarun M. Kapoor, Moriteru Asano, Kazuyoshi Aso, Michael A. Foley, Yoshiyuki Fukase, Hideki Furukawa, Yashuhiro Hirata, Sachie Takashima, Tomohiro Okawa, Yuta Tanaka, Yayoi Yoshitomi
  • AMIDE COMPOUND
    Publication number: 20210277030
    Abstract: The present invention relates to compound (I) or a salt thereof which has a ROR?t inhibitory action. In the formula (I), each symbol is as defined in the specification.
    Type: Application
    Filed: May 10, 2021
    Publication date: September 9, 2021
    Inventors: Satoshi Yamamoto, Junya Shirai, Mitsunori Kono, Yoshihide Tomata, Ayumu Sato, Atsuko Ochida, Yoshiyuki Fukase, Shoji Fukumoto, Tsuneo Oda, Hidekazu Tokuhara, Naoki Ishii, Yusuke Sasaki
  • Heterocyclic amide compounds having RORyT inhibitory action
    Patent number: 11053262
    Abstract: The present invention relates to compound (I) or a salt thereof which has a ROR?t inhibitory action. In the formula (I), each symbol is as defined in the specification.
    Type: Grant
    Filed: September 19, 2019
    Date of Patent: July 6, 2021
    Assignee: TAKEDA PHARMACEUTICAL COMPANY LIMITED
    Inventors: Satoshi Yamamoto, Junya Shirai, Mitsunori Kono, Yoshihide Tomata, Ayumu Sato, Atsuko Ochida, Yoshiyuki Fukase, Shoji Fukumoto, Tsuneo Oda, Hidekazu Tokuhara, Naoki Ishii, Yusuke Sasaki
  • PYRIDINONE- AND PYRIDAZINONE-BASED COMPOUNDS AND USES THEREOF
    Publication number: 20200407339
    Abstract: The various examples presented herein are directed to compounds of the formula A-L1-Het1-L2-Cy1 or a pharmaceutical acceptable salt, polymorph, prodrug, solvate or clathrate thereof, wherein: A is cycloalkyl, aryl, arylalkyl or heterocyclyl; Het1 is heterocyclyl containing at least two heteroatoms; Cy1 is a heterocyclyl; L1 is a bond, alkyl, alkenyl or alkynyl linker; L2 is an acyl or alkyl linker; and A and Cy1 are different. The compounds are useful in the treatment of fibrotic diseases, abnormal vascular leak and pathological angiogenesis.
    Type: Application
    Filed: March 8, 2019
    Publication date: December 31, 2020
    Inventors: Timothy Hla, Irina Jilishitz, Peter Meinke, Andrew Stamford, Michael Foley, Ayumu Sato, Yasufimi Wada, Yoshiyuki Fukase, Asato Kina, Hiroki Takahagi, Hideyuki Igawa, William J. Polvino
  • AGENTS AND METHODS FOR TREATING DYSPROLIFERATIVE DISEASES
    Publication number: 20200392099
    Abstract: Compounds are described with the general formula (I) wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R12, and n are defined as anywhere herein, which are useful for the treatment of cancer and other dysproliferative diseases.
    Type: Application
    Filed: February 18, 2019
    Publication date: December 17, 2020
    Applicant: Memorial Sloan-kettering Cancer Center
    Inventors: YOSHIYUKI FUKASE, MARK DUGGAN, HANS-GUIDO WENDEL, KAMINI SINGH
  • PYRAZOLOQUINAZOLINONE ANTITUMOR AGENTS
    Publication number: 20200148687
    Abstract: Compounds of formula: are useful as antitumor agents. In these compounds, R10 is (a) (C1-C10) hydrocarbyl, (C1-C10)halohydrocarbyl, (C1-C6)hydroxyalkyl, or or R10 is (b) in which Q and A are linkers and Ar is optionally substituted monocyclic or bicyclic aryl or heteroaryl.
    Type: Application
    Filed: May 18, 2018
    Publication date: May 14, 2020
    Applicant: The Rockefeller University
    Inventors: Tarun M. KAPOOR, Moriteru ASANO, Kazuyoshi ASO, Michael A. FOLEY, Yoshiyuki FUKASE, Hideki FURUKAWA, Yashuhiro HIRATA, Sachie TAKASHIMA, Tomohiro OKAWA, Yuta TANAKA, Yayoi YOSHITOMI
  • AMIDE COMPOUND
    Publication number: 20200010487
    Abstract: The present invention relates to compound (I) or a salt thereof which has a ROR?t inhibitory action. In the formula (I), each symbol is as defined in the specification.
    Type: Application
    Filed: September 19, 2019
    Publication date: January 9, 2020
    Inventors: Satoshi Yamamoto, Junya Shirai, Mitsunori Kono, Yoshihide Tomata, Ayumu Sato, Atsuko Ochida, Yoshiyuki Fukase, Shoji Fukumoto, Tsuneo Oda, Hidekazu Tokuhara, Naoki Ishii, Yusuke Sasaki
  • Amide compound
    Patent number: 10472376
    Abstract: The present invention relates to compound (I) or a salt thereof which has a ROR?t inhibitory action. In the formula (I), each symbol is as defined in the specification.
    Type: Grant
    Filed: July 2, 2014
    Date of Patent: November 12, 2019
    Assignee: TAKEDA PHARMACEUTICAL COMPANY LIMITED
    Inventors: Satoshi Yamamoto, Junya Shirai, Mitsunori Kono, Yoshihide Tomata, Ayumu Sato, Atsuko Ochida, Yoshiyuki Fukase, Shoji Fukumoto, Tsuneo Oda, Hidekazu Tokuhara, Naoki Ishii, Yusuke Sasaki
  • HETEROCYCLIC COMPOUND
    Publication number: 20180319812
    Abstract: The present invention relates to compound (I) or a salt thereof which has a ROR?t inhibitory action. wherein each symbol is as defined in the specification.
    Type: Application
    Filed: July 13, 2018
    Publication date: November 8, 2018
    Inventors: Satoshi Yamamoto, Junya Shirai, Hiroyuki Watanabe, Shoji Fukumoto, Tsuneo Oda, Hidekazu Tokuhara, Yoshihide Tomata, Naoki Ishii, Michiko Tawada, Mitsunori Kono, Atsuko Ochida, Takashi Imada, Yoshiyuki Fukase, Tomoya Yukawa
  • Heterocyclic compounds and their use as retinoid-related orphan receptor (ROR) gamma-T inhibitors
    Patent number: 10093629
    Abstract: Provided are heterocyclic compounds having a ROR?t inhibitory action represented by the formula (I): wherein each symbol is as defined in the specification, or a salt thereof.
    Type: Grant
    Filed: June 30, 2015
    Date of Patent: October 9, 2018
    Assignee: Takeda Pharmaceutical Company Limited
    Inventors: Satoshi Yamamoto, Junya Shirai, Tsuneo Oda, Mitsunori Kono, Atsuko Ochida, Takashi Imada, Hidekazu Tokuhara, Yoshihide Tomata, Naoki Ishii, Michiko Tawada, Yoshiyuki Fukase, Tomoya Yukawa, Shoji Fukumoto
  • Heterocyclic compound
    Patent number: 10053468
    Abstract: The present invention relates to compound (I) or a salt thereof which has a ROR?t inhibitory action. wherein each symbol is as defined in the specification.
    Type: Grant
    Filed: July 2, 2014
    Date of Patent: August 21, 2018
    Assignee: Takeda Pharmaceutical Company Limited
    Inventors: Satoshi Yamamoto, Junya Shirai, Hiroyuki Watanabe, Shoji Fukumoto, Tsuneo Oda, Hidekazu Tokuhara, Yoshihide Tomata, Naoki Ishii, Michiko Tawada, Mitsunori Kono, Atsuko Ochida, Takashi Imada, Yoshiyuki Fukase, Tomoya Yukawa
  • Heterocyclic compound
    Patent number: 10000488
    Abstract: The problem of the present invention is to provide a compound having a superior ROR?t inhibitory action, and useful as a prophylactic or therapeutic agent for psoriasis, inflammatory bowel disease, ulcerative colitis, Crohn's disease, rheumatoid arthritis, multiple sclerosis, uveitis, asthma, ankylopoietic spondylarthritis, systemic lupus erythematosus, chronic obstructive pulmonary disease or the like. The present invention relates to a compound represented by the formula (I): [wherein each symbol is as described in the DESCRIPTION] or a salt thereof, which has an ROR?t inhibitory action, and useful as a prophylactic or therapeutic agent for psoriasis, inflammatory bowel disease, ulcerative colitis, Crohn's disease, rheumatoid arthritis, multiple sclerosis, uveitis, asthma, ankylopoietic spondylarthritis, systemic lupus erythematosus, chronic obstructive pulmonary disease or the like.
    Type: Grant
    Filed: September 10, 2015
    Date of Patent: June 19, 2018
    Assignee: Takeda Pharmaceutical Company Limited
    Inventors: Satoshi Yamamoto, Junya Shirai, Tsuneo Oda, Takashi Imada, Mitsunori Kono, Ayumu Sato, Yoshihide Tomata, Atsuko Ochida, Naoki Ishii, Yusuke Sasaki, Yoshiyuki Fukase, Tomoya Yukawa, Shoji Fukumoto
  • Heterocyclic compound
    Patent number: 9834520
    Abstract: The present invention provides a heterocyclic compound having an ROR?t inhibitory action. The present invention relates to a compound represented by the formula (I): wherein Ar is a the partial structure (1) to the partial structure (5), Q is a bivalent group selected from the group consisting of (Ia)-(If), and B is a ring optionally having substituent(s), or a salt thereof.
    Type: Grant
    Filed: March 13, 2014
    Date of Patent: December 5, 2017
    Assignee: Takeda Pharmaceutical Company Limited
    Inventors: Satoshi Yamamoto, Junya Shirai, Yoshiyuki Fukase, Ayumu Sato, Mitsunori Kouno, Yoshihide Tomata, Atsuko Ochida, Kazuko Yonemori, Tsuneo Oda, Tomoya Yukawa
  • HETEROCYCLIC COMPOUND
    Publication number: 20170253591
    Abstract: The problem of the present invention is to provide a compound having a superior ROR?t inhibitory action, and useful as a prophylactic or therapeutic agent for psoriasis, inflammatory bowel disease, ulcerative colitis, Crohn's disease, rheumatoid arthritis, multiple sclerosis, uveitis, asthma, ankylopoietic spondylarthritis, systemic lupus erythematosus, chronic obstructive pulmonary disease or the like. The present invention relates to a compound represented by the formula (I): [wherein each symbol is as described in the DESCRIPTION] or a salt thereof, which has an ROR?t inhibitory action, and useful as a prophylactic or therapeutic agent for psoriasis, inflammatory bowel disease, ulcerative colitis, Crohn's disease, rheumatoid arthritis, multiple sclerosis, uveitis, asthma, ankylopoietic spondylarthritis, systemic lupus erythematosus, chronic obstructive pulmonary disease or the like.
    Type: Application
    Filed: September 10, 2015
    Publication date: September 7, 2017
    Inventors: Satoshi YAMAMOTO, Junya SHIRAI, Tsuneo ODA, Takashi IMADA, Mitsunori KONO, Ayumu SATO, Yoshihide TOMATA, Atsuko OCHIDA, Naoki ISHII, Yusuke SASAKI, Yoshiyuki FUKASE, Tomoya YUKAWA, Shoji FUKUMOTO
  • HETEROCYCLIC COMPOUNDS AND THEIR USE AS RETINOID-RELATED ORPHAN RECEPTOR (ROR) GAMMA-T INHIBITORS
    Publication number: 20170144973
    Abstract: Provided are heterocyclic compounds having a ROR?t inhibitory action represented by the formula (I): wherein each symbol is as defined in the specification, or a salt thereof.
    Type: Application
    Filed: June 30, 2015
    Publication date: May 25, 2017
    Applicant: Takenda Pharmaceutical Company Limited
    Inventors: Satoshi YAMAMOTO, Junya SHIRAI, Tsuneo ODA, Mitsunori KONO, Atsuko OCHIDA, Takashi IMADA, Hidekazu TOKUHARA, Yoshihide TOMATA, Naoki ISHII, Michiko TAWADA, Yoshiyuki FUKASE, Tomoya YUKAWA, Shoji FUKUMOTO
  • Heterocyclic compound
    Patent number: 9650343
    Abstract: The present invention provides a heterocyclic compound having a ROR?t inhibitory action. The present invention relates to a compound represented by the formula (I): wherein each symbol is as defined in the specification. or a salt thereof.
    Type: Grant
    Filed: February 26, 2016
    Date of Patent: May 16, 2017
    Assignee: Takeda Pharmaceutical Company Limited
    Inventors: Satoshi Yamamoto, Junya Shirai, Tsuneo Oda, Mitsunori Kono, Atsuko Ochida, Takashi Imada, Hidekazu Tokuhara, Yoshihide Tomata, Naoki Ishii, Michiko Tawada, Yoshiyuki Fukase, Tomoya Yukawa, Shoji Fukumoto
  • Heterocyclic compound
    Patent number: 9630924
    Abstract: The present invention provides a heterocyclic compound having a ROR?t inhibitory action. The present invention relates to a compound represented by the formula (I): wherein each symbol is as defined in the specification. or a salt thereof.
    Type: Grant
    Filed: February 26, 2016
    Date of Patent: April 25, 2017
    Assignee: Takeda Pharmaceutical Company Limited
    Inventors: Satoshi Yamamoto, Junya Shirai, Tsuneo Oda, Mitsunori Kono, Atsuko Ochida, Takashi Imada, Hidekazu Tokuhara, Yoshihide Tomata, Naoki Ishii, Michiko Tawada, Yoshiyuki Fukase, Tomoya Yukawa, Shoji Fukumoto