Yuji Ito has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
Abstract: The invention relates to an antibody which binds to cell adhesion molecule 3 (CADM3) or an antibody fragment thereof, a hybridoma which produces the antibody or the antibody fragment thereof, a nucleic acid comprising a nucleotide sequence encoding the antibody or the antibody fragment thereof, a transformant cell comprising a vector comprising the nucleic acid, a method for producing the antibody or the antibody fragment thereof, a composition comprising the antibody or the antibody fragment thereof, and a method for detecting or measuring an antigen present in the brain, a method for diagnosing or treating a brain disease, a method for enhancing the property of accumulating in a brain of an antibody, and a method for increasing the amount of an antibody in the brain, each of which using the antibody or the antibody fragment thereof, and the like.
June 26, 2019
Date of Patent:
January 16, 2024
KYOWA KIRIN CO., LTD., KAGOSHIMA UNIVERSITY
Abstract: A lithium ion battery lifetime prediction method executes, by a computer, acquiring training data including cycle measurement data and lifetime data of a battery, learning a lifetime prediction model using the training data with respect to one or more cycle numbers at which a prediction is made, to acquire a set of learned lifetime prediction models corresponding to the cycle numbers at which the prediction is made, respectively, successively acquiring cycle measurement data for prediction of a battery that is a prediction target, up to the cycle numbers at which the prediction is made, respectively, and inputting the cycle measurement data for prediction acquired up to the cycle numbers at which the prediction is made, to the learned lifetime prediction models of the corresponding cycle numbers at which the prediction is made, and acquiring a probability distribution of a lifetime at the cycle numbers at which the prediction is made, respectively, as an output.
Abstract: A method of manufacturing a micro-oscillator includes: preparing a substrate having a flat portion and a curved surface portion formed in a three-dimensional curved shape protruding from one surface of the flat portion, the curved surface portion being surrounded by the flat portion; and irradiating an outer surface of the curved surface portion with a laser beam to separate the curved surface portion from the flat portion.
Abstract: An object of the present invention is to provide carbon-coated Si—C composite particles capable of maintaining a high Si utilization rate and suppressing deterioration of initial coulombic efficiency due to oxidation over time of a lithium-ion secondary battery. The carbon-coated Si—C composite particles of the present invention includes Si—C composite particles containing a carbon material and silicon; and a carbonaceous layer present on surfaces of the Si—C composite particles, wherein the carbon coverage thereof is 70% or more, wherein the BET specific surface area is 200 m2/g or less; wherein R value (ID/IG) is 0.30 or more and 1.10 or less and ISi/IG is 0.15 or less, when the peak attributed to Si is present at 450 to 495 cm?1 and the intensity of the peak is defined as ISi, in Raman spectrum of the carbon-coated Si—C composite particles: and wherein the full width at half maximum of the peak of a 111 plane of Si is 3.00 deg.
Abstract: Composite carbon particles including a porous carbon material and a silicon component, the composite carbon particle having an average aspect ratio of 1.25 or less, and a ratio (ISi/IG) of a peak intensity (ISi) in the vicinity of 470 cm?1 to a peak intensity (IG) in the vicinity of 1580 cm?1 as measured by Raman spectroscopy of 0.30 or less, wherein the porous carbon material satisfies V1/V0>0.80 and V2/V0<0.10, when a total pore volume at a maximum value of a relative pressure P/P0 is defined as V0 and P0 is a saturated vapor pressure, a cumulative pore volume at a relative pressure P/P0=0.1 is defined as V1, a cumulative pore volume at a relative pressure P/P0=10?7 is defined as V2 in a nitrogen adsorption test, and has a BET specific surface area of 800 m2/g or more.
Abstract: Described is a labeling technique which can facilitate the metabolism in the liver after administration to patients without the reduction in the antibody function, thereby reducing accumulation of radionuclides in an organ such as the liver, and a modified antibody containing an IgG antibody and an IgG-binding peptide bound to the IgG antibody. The IgG-binding peptide has an amino acid sequence consisting of 13 to 17 amino acid residues, such as GPDCAYH(Xaa1)GELVWCTFH (SEQ ID NO: 2) wherein Xaa1 represents a lysine residue, a cysteine residue, an aspartic acid residue, a glutamic acid residue, 2-aminosuberic acid, or diaminopropionic acid, and a compound represented by the following formula (II-1) is linked at a position of the lysine residue via a modification linker to the N terminus of the IgG-binding peptide.
April 15, 2019
Date of Patent:
July 18, 2023
NIHON MEDI-PHYSICS CO., LTD., NATIONAL UNIVERSITY CORPORATION KAGOSHIMA UNIVERSITY, NATIONAL UNIVERSITY CORPORATION CHIBA UNIVERSITY
Abstract: The present invention relates to composite particles containing silicon and carbon, wherein a domain size region of vacancies of 2 nm or less is 44% by volume or more and 70% by volume or less when volume distribution information of domain sizes obtained by fitting a small-angle X-ray scattering spectrum of the composite particles with a spherical model in a carbon-vacancy binary system is accumulated in ascending order, and a true density calculated by dry density measurement by a constant volume expansion method using helium gas is 1.80 g/cm3 or more and 2.20 g/cm3 or less.
Abstract: A peptide vaccine complexed so that the peptide vaccine can be delivered specifically to the surface of specific immune cells and a method for delivering a peptide vaccine specifically to the surface of specific immune cells. The peptide vaccine is combined with an IgG binding peptide capable of binding to an IgG that is an agonist against molecules on the surface of specific immune cells such as dendritic cells.
Abstract: An object of the present invention is to provide composite particles capable of suppressing oxidation over time of a Si—C composite material. Composite particles (B) of the present invention contains composite particles (A) containing carbon and silicon; and amorphous layers coating surfaces thereof, where the composite particles (B) have ISi/IG of 0.10 or more and 0.65 or less, and have R value (ID/IG) of 1.00 or more and 1.30 or less, when a peak due to silicon is present at 450 to 495 cm?1, an intensity of the peak is defined as ISi, an intensity of a G band (peak intensity in the vicinity of 1600 cm?1) is defined as IG, and an intensity of a D band (peak intensity in the vicinity of 1360 cm?1) is defined as ID in a Raman spectrum, and where the composite particles (B) have a full width at half maximum of a peak of a 111 plane of Si of 3.0 deg. or more using a Cu-K? ray in an XRD pattern.
Abstract: A negative electrode material for a lithium-ion secondary battery containing a composite (C) that contains a porous carbon (A) and a Si-containing compound (B). The porous carbon (A) satisfies V1/V0>0.80 and V2/V0<0.10. When a total pore volume at the maximum value of a relative pressure P/P0 is defined as V0 and P0 is a saturated vapor pressure, a cumulative pore volume at a relative pressure P/P0=0.1 is defined as V1, and a cumulative pore volume at a relative pressure P/P0=10?7 is defined as V2 in a nitrogen adsorption test. Further, the porous carbon (A) has a BET specific surface area of 800 m2/g or more, and the Si-containing compound (B) is contained in pores of the porous carbon (A). Also disclosed is a negative electrode sheet including the negative electrode material and a lithium-ion secondary battery including the negative electrode sheet.
Abstract: An object of the present invention is to provide a method by which a peptide having a specific binding capability that can be used for purification of a target molecule can be produced at a low cost, and specifically relates to a peptide fusion protein including one or more peptides having specific binding capability and a scaffold protein, the peptide being inserted into the amino acid sequence of the scaffold protein directly or via a peptide linker, and/or being linked to the N-terminal and/or C-terminal of the scaffold protein.
Abstract: The present disclosure provides a busbar unit capable of improving the detection accuracy of the temperature of a busbar by a temperature sensor. The busbar unit (10) comprises a busbar (13), a temperature sensor (14), an insulating covering member (7) that is made of resin and covers the busbar (13) and the temperature sensor (14). The temperature sensor (14) has a thermistor element (41) and a case (51) that accommodates the thermistor element (41). The busbar (13) has a sensor holding part (22) that holds the temperature sensor (14). The sensor holding part (22) has a first support part (31) having a first contact surface (31a), a second support part (32) having a second contact surface (32a) facing the first contact surface (31a), and a connection part that connects ends of the first support part (31) and the second support part (32). The sensor holding part (22) holds the temperature sensor (14) by sandwiching the case (51) between the first contact surface (31a) and the second contact surface (32a).
Abstract: One aspect of the present disclosure provides a terminal block capable of improving mounting position accuracy. A terminal block according to the one aspect of the present disclosure includes a plate made of metal and to be fixed to a first case made of metal, a housing held on the plate, and a plurality of terminals held in the housing. The plate includes a first positioning hole through which a first positioning pin is inserted.
Abstract: A point which requires visual attention is added to map data. A map data generation device acquires image data in which the outside is captured from a vehicle by an input device and a point data of the vehicle, associates both data, and generates a visual saliency map acquired by estimating fluctuation of visual saliency based on the image data by the visual saliency extraction unit. Then, whether or not a point or a section indicated by position information corresponding to the visual saliency map is a point or a section which requires visual attention is analyzed based on the visual saliency map by an analysis unit, and the point or the section which requires the visual attention is added to the map data based on an analysis result of the analysis unit by an addition device.
Abstract: A sleeve is provided inside a body configuring a channel selector valve, and first and second guide portions with which outer peripheries of first and second land portions of a valve body are in sliding contact are formed on one end side and the other end side of the sleeve. The first and second guide portions are formed to axially overlap with the first and second land portions so as to abut the first and second land portions at all times when the valve body axially moves. The valve body includes a plurality of communicating paths penetrating through the valve body in the axial direction, and, in the sleeve, a first space formed on one end side of the valve body and a second space formed on the other end side of the valve body communicate with each other via the communicating paths.
March 24, 2020
Date of Patent:
December 6, 2022
HITACHI ASTEMO, LTD.
Naoki Oikawa, Yuta Soma, Ken Motohashi, Yuji Ito
Abstract: An objective is to provide an Fc-modified antibody or the like having a long serum half-life according to a CCAP method, more specifically, an antibody or the like where IgBP is bound to only one site, based on findings of the inventors. Provided is an objective antibody or the like by purification and production of an Fc-modified antibody or the like with a column bound to an Fc region of an antibody. Specifically, an antibody where only one of two binding sites of Fc is selectively modified is provided by allowing an IgBP-bound antibody produced by a CCAP method to adsorb to a carrier of an IgBP-immobilized column, or forming a state where only one Fc of an antibody is bound to an IgBP binding column and then adding a peptide reagent for CCAP to the column to perform a reaction of a CCAP method in the column.
Abstract: It is an object of the present invention to provide a method for modifying an antibody in a specific and simple manner, and others. The present invention relates to: an IgG-binding peptide, an IgG-binding peptide modified with a crosslinking agent, a complex of an IgG-binding peptide modified with the crosslinking agent and IgG, a method for producing the complex, and others.
Abstract: A stirring and defoaming device is a stirring and defoaming device of a revolution and rotation type, wherein a vacuum unit for sucking air in each container to bring the inside of each container into a vacuum state includes sealing bodies that seal respective containers, a vacuum generation source, a suction path running toward a revolution center with each container as a starting end, passing through the revolution center to go outside the system, and reaching the vacuum generation source placed outside the system, at least part of the suction path being an independent path from the starting end in association with each container, and at least two or more vacuum measurement units, each provided in an independent path.