Abstract: An object is to provide a resin composition having a high permittivity and a low dissipation factor, and having low water absorption, favorable thermal characteristics, a high glass transition temperature, a high peel strength of the metal foil, and a low coefficient of thermal expansion, and suitably used for producing an insulation layer of a printed wiring board; and a prepreg, a resin sheet, a laminate, a metal foil-clad laminate, and a printed wiring board obtainable by using the resin composition. The resin composition of the present invention contains: (A) a dielectric powder, (B) a cyanate ester compound, and (C) an epoxy compound, wherein a functional group equivalent ratio of a cyanate group of the cyanate ester compound (B) to an epoxy group of the epoxy compound (C) (cyanate group/epoxy group) is 0.1 to 2.0.

Abstract: Provision of an affinity carrier using a mutant VHH antibody. An affinity carrier comprising: a solid phase carrier; and an immunoglobulin-binding protein bound to the solid phase carrier; wherein the immunoglobulin-binding protein comprises a mutant VHH antibody or a fragment of the mutant VHH antibody that recognizes an epitope in at least one region selected from the group consisting of amino acids 127 to 184 of SEQ ID NO: 22 and amino acids 13 to 210 of SEQ ID NO: 23.

Abstract: A crosslinking agent for a protein or a peptide is represented by the following formula (I). In the formula, A is a hydrogen atom, a C1 to 6 alkyl group optionally substituted with a phenyl group or a halogen atom, or a phenyl group.

Abstract: A negative electrode material for a lithium-ion secondary battery containing a composite (C) that contains a porous carbon (A) and a Si-containing compound (B). The porous carbon (A) satisfies V1/V0>0.80 and V2/V0<0.10. When a total pore volume at the maximum value of a relative pressure P/P0 is defined as V0 and P0 is a saturated vapor pressure, a cumulative pore volume at a relative pressure P/P0=0.1 is defined as V1, and a cumulative pore volume at a relative pressure P/P0=10?7 is defined as V2 in a nitrogen adsorption test. Further, the porous carbon (A) has a BET specific surface area of 800 m2/g or more, and the Si-containing compound (B) is contained in pores of the porous carbon (A). Also disclosed is a negative electrode sheet including the negative electrode material and a lithium-ion secondary battery including the negative electrode sheet.

Abstract: Composite carbon particles including a porous carbon material and a silicon component, the composite carbon particle having an average aspect ratio of 1.25 or less, and a ratio (ISi/IG) of a peak intensity (ISi) in the vicinity of 470 cm?1 to a peak intensity (IG) in the vicinity of 1580 cm?1 as measured by Raman spectroscopy of 0.30 or less, wherein the porous carbon material satisfies V1/V0>0.80 and V2/V0<0.10, when a total pore volume at a maximum value of a relative pressure P/P0 is defined as V0 and P0 is a saturated vapor pressure, a cumulative pore volume at a relative pressure P/P0=0.1 is defined as V1, a cumulative pore volume at a relative pressure P/P0=10?7 is defined as V2 in a nitrogen adsorption test, and has a BET specific surface area of 800 m2/g or more.

Abstract: The present invention relates to an IgG-binding peptide comprising a ligand capable of binding to a radioactive metal nuclide, an IgG-binding peptide labeled with a radioactive metal nuclide, a conjugate of the IgG-binding peptide and IgG, and a radionuclide imaging agent or a diagnostic agent for cancer comprising the IgG-binding peptide or the conjugate, etc.

Abstract: The present invention provides a technique enabling modification of a soluble protein and in particular regioselective modification of a soluble protein. More specifically, the present invention provides a compound having an affinity substance to a soluble protein, a cleavable portion, and a reactive group represented by the following Formula (I): A-L-B-R??(I) wherein A is an affinity substance to a soluble protein; L is a cleavable linker which is a divalent group comprising a cleavable portion; B is (a) a divalent group comprising a bioorthogonal functional group or (b) a divalent group comprising no bioorthogonal functional group; and R is a reactive group to the soluble protein; or a salt thereof.

Abstract: A method of manufacturing a micro-oscillator includes: preparing a substrate having a flat portion and a curved surface portion formed in a three-dimensional curved shape protruding from one surface of the flat portion, the curved surface portion being surrounded by the flat portion; and irradiating an outer surface of the curved surface portion with a laser beam to separate the curved surface portion from the flat portion.

Abstract: A composite particle including carbon and silicon, in which the composite particle contains a crystalline metal oxide particle, and the end of the metal oxide particle is present inside the surface of the composite particle, and pores are present on the surface of the composite particle. According to the present invention, there can be provided a composite particle, in which silicon is attached to the inside of fine pores of a carbon material that has been provided with specific fine pores, the composite particle also contains a crystalline metal oxide particle, the end of the metal oxide particle is present inside the surface of the composite particle, and furthermore, pores are present on the surface of the composite particle. By using this composite particle, a lithium-ion secondary battery with excellent rate characteristics and cycle characteristics can be provided.

Abstract: A stirring and defoaming device is a stirring and defoaming device of a revolution and rotation type, wherein a vacuum unit for sucking air in each container to bring the inside of each container into a vacuum state includes sealing bodies that seal respective containers, a vacuum generation source, a suction path running toward a revolution center with each container as a starting end, passing through the revolution center to go outside the system, and reaching the vacuum generation source placed outside the system, at least part of the suction path being an independent path from the starting end in association with each container, and at least two or more vacuum measurement units, each provided in an independent path.

Abstract: A composite particle includes a particle including a carbon material and silicon, and a coating layer including carbon and oxygen on the surface of the particle, in which the composite particle has a true density of 1.80 to 1.99 g/cm3; in the Raman spectrum, a peak is present at 450 to 495 cm?1, and when the intensity of the peak is defined as ISi and the intensity of the G band is defined as IG, ISi/IG is 1.3 or less; and when the ratios of the number of atoms of Si, O, and C in X-ray photoelectron spectroscopy are defined as ASi, AO, and AC, respectively, and the ratios of SiO2 and SiO are defined as BSiO2 and BSiO, respectively, ASi is 0.05 or more, and ISi/IG and AC/(AC+ASi×(BSiO2+BSiO)) have predetermined relationships.

Abstract: One embodiment of the present invention is composite particles containing silicon and carbon, which are characterized as follows. When the cross-sectional diameter and the silicon content rate of the composite particles are measured by cross-sectional SEM-EDS and composite particles having a cross-sectional diameter of half or less than the number average of the cross-sectional diameter are defined as small diameter composite particles, the proportion of the number of the small diameter composite particles in the number of the composite particles measured is 5% or more and 50% or less, the ratio of the average silicon content rate (% by mass) of particles other than the small diameter composite particles to the average silicon content rate (% by mass) of the small diameter composite particles is 0.90 or less, and the silicon content rate of the entire composite particles is 45% by mass or more.

Abstract: The present invention relates to an IgG-binding peptide comprising a ligand capable of binding to a radioactive metal nuclide, an IgG-binding peptide labeled with a radioactive metal nuclide, a conjugate of the IgG-binding peptide and IgG, and a radionuclide imaging agent or a diagnostic agent for cancer comprising the IgG-binding peptide or the conjugate, etc.

Abstract: The present invention provides a technique enabling modification of a soluble protein and in particular regioselective modification of a soluble protein. More specifically, the present invention provides a compound having an affinity substance to a soluble protein, a cleavable portion, and a reactive group represented by the following Formula (I): A-L-B-R??(I) wherein A is an affinity substance to a soluble protein; L is a cleavable linker which is a divalent group comprising a cleavable portion; B is (a) a divalent group comprising a bioorthogonal functional group or (b) a divalent group comprising no bioorthogonal functional group; and R is a reactive group to the soluble protein; or a salt thereof.

Abstract: A stirring and defoaming device is a stirring and defoaming device of a revolution and rotation type, wherein a vacuum unit for sucking air in each container to bring the inside of each container into a vacuum state includes sealing bodies that seal respective containers, a vacuum generation source, a suction path running toward a revolution center with each container as a starting end, passing through the revolution center to go outside the system, and reaching the vacuum generation source placed outside the system, at least part of the suction path being an independent path from the starting end in association with each container, and at least two or more vacuum measurement units, each provided in an independent path.

Abstract: The present invention relates to composite particles containing silicon and carbon, wherein a domain size region of vacancies of 2 nm or less is 44% by volume or more and 70% by volume or less when volume distribution information of domain sizes obtained by fitting a small-angle X-ray scattering spectrum of the composite particles with a spherical model in a carbon-vacancy binary system is accumulated in ascending order, and a true density calculated by dry density measurement by a constant volume expansion method using helium gas is 1.80 g/cm3 or more and 2.20 g/cm3 or less.

Abstract: The invention relates to an antibody which binds to chondroitin sulfate proteoglycan 5 (CSPG5) or an antibody fragment thereof, a hybridoma which produces the antibody or the antibody fragment thereof, a nucleic acid comprising a nucleotide sequence encoding the antibody or the antibody fragment thereof, a transformant cell comprising a vector comprising the nucleic acid, a method for producing the antibody or the antibody fragment thereof, a composition comprising the antibody or the antibody fragment thereof, and a method for detecting or measuring an antigen present in the brain, a method for diagnosing or treating a brain disease, a method for enhancing the property of accumulating in a brain of an antibody, and a method for increasing the amount of an antibody in the brain, each of which using the antibody or the antibody fragment thereof, and the like.

Abstract: The invention relates to an antibody which binds to myelin oligodendrocyte glycoprotein (MOG), an antibody fragment thereof, a hybridoma which produces the antibody or the antibody fragment, a nucleic acid containing a nucleotide sequence which encodes the antibody or the antibody fragment, a transformant cell containing a vector containing the nucleic acid, a method for producing the antibody or the antibody fragment, a composition containing the antibody or the antibody fragment and a method for detecting or measuring an antigen that is present in the brain, a method for diagnosing or treating a brain disease, a method for improving the property of an antibody of accumulating in the brain and a method for increasing the amount of an antibody in the brain which use the antibody or the antibody fragment.

Abstract: The invention relates to an antibody which binds to cell adhesion molecule 3 (CADM3) or an antibody fragment thereof, a hybridoma which produces the antibody or the antibody fragment thereof, a nucleic acid comprising a nucleotide sequence encoding the antibody or the antibody fragment thereof, a transformant cell comprising a vector comprising the nucleic acid, a method for producing the antibody or the antibody fragment thereof, a composition comprising the antibody or the antibody fragment thereof, and a method for detecting or measuring an antigen present in the brain, a method for diagnosing or treating a brain disease, a method for enhancing the property of accumulating in a brain of an antibody, and a method for increasing the amount of an antibody in the brain, each of which using the antibody or the antibody fragment thereof, and the like.

Abstract: A lithium ion battery lifetime prediction method executes, by a computer, acquiring training data including cycle measurement data and lifetime data of a battery, learning a lifetime prediction model using the training data with respect to one or more cycle numbers at which a prediction is made, to acquire a set of learned lifetime prediction models corresponding to the cycle numbers at which the prediction is made, respectively, successively acquiring cycle measurement data for prediction of a battery that is a prediction target, up to the cycle numbers at which the prediction is made, respectively, and inputting the cycle measurement data for prediction acquired up to the cycle numbers at which the prediction is made, to the learned lifetime prediction models of the corresponding cycle numbers at which the prediction is made, and acquiring a probability distribution of a lifetime at the cycle numbers at which the prediction is made, respectively, as an output.