Patents by Inventor Yuji Ito
Yuji Ito has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240250242Abstract: One embodiment of the present invention is composite particles containing silicon and carbon, which are characterized as follows. When the cross-sectional diameter and the silicon content rate of the composite particles are measured by cross-sectional SEM-EDS and composite particles having a cross-sectional diameter of half or less than the number average of the cross-sectional diameter are defined as small diameter composite particles, the proportion of the number of the small diameter composite particles in the number of the composite particles measured is 5% or more and 50% or less, the ratio of the average silicon content rate (% by mass) of particles other than the small diameter composite particles to the average silicon content rate (% by mass) of the small diameter composite particles is 0.90 or less, and the silicon content rate of the entire composite particles is 45% by mass or more.Type: ApplicationFiled: May 26, 2022Publication date: July 25, 2024Applicant: Resonac CorporationInventors: Yuji ITO, Masato FUJiTA, Akihisha TONEGAWA, Takayuki KURITA, Hirofumi INOUE
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Patent number: 12037417Abstract: The present invention relates to an IgG-binding peptide comprising a ligand capable of binding to a radioactive metal nuclide, an IgG-binding peptide labeled with a radioactive metal nuclide, a conjugate of the IgG-binding peptide and IgG, and a radionuclide imaging agent or a diagnostic agent for cancer comprising the IgG-binding peptide or the conjugate, etc.Type: GrantFiled: June 12, 2017Date of Patent: July 16, 2024Assignee: Kagoshima UniversityInventors: Yuji Ito, Yoshinari Shoyama, Akio Hayashi, Norihito Nakata
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Patent number: 12024549Abstract: The present invention provides a technique enabling modification of a soluble protein and in particular regioselective modification of a soluble protein. More specifically, the present invention provides a compound having an affinity substance to a soluble protein, a cleavable portion, and a reactive group represented by the following Formula (I): A-L-B-R??(I) wherein A is an affinity substance to a soluble protein; L is a cleavable linker which is a divalent group comprising a cleavable portion; B is (a) a divalent group comprising a bioorthogonal functional group or (b) a divalent group comprising no bioorthogonal functional group; and R is a reactive group to the soluble protein; or a salt thereof.Type: GrantFiled: October 25, 2019Date of Patent: July 2, 2024Assignee: Ajinomoto Co., Inc.Inventors: Kei Yamada, Yutaka Matsuda, Tomohiro Fujii, Natsuki Shikida, Reiko Yuji, Kazutaka Shimbo, Yuji Ito
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Patent number: 11998881Abstract: A stirring and defoaming device is a stirring and defoaming device of a revolution and rotation type, wherein a vacuum unit for sucking air in each container to bring the inside of each container into a vacuum state includes sealing bodies that seal respective containers, a vacuum generation source, a suction path running toward a revolution center with each container as a starting end, passing through the revolution center to go outside the system, and reaching the vacuum generation source placed outside the system, at least part of the suction path being an independent path from the starting end in association with each container, and at least two or more vacuum measurement units, each provided in an independent path.Type: GrantFiled: March 19, 2020Date of Patent: June 4, 2024Assignee: SHASHIN KAGAKU CO., LTD.Inventors: Yuji Ito, Fumihiko Takaoka
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Patent number: 12002958Abstract: The present invention relates to composite particles containing silicon and carbon, wherein a domain size region of vacancies of 2 nm or less is 44% by volume or more and 70% by volume or less when volume distribution information of domain sizes obtained by fitting a small-angle X-ray scattering spectrum of the composite particles with a spherical model in a carbon-vacancy binary system is accumulated in ascending order, and a true density calculated by dry density measurement by a constant volume expansion method using helium gas is 1.80 g/cm3 or more and 2.20 g/cm3 or less.Type: GrantFiled: May 28, 2021Date of Patent: June 4, 2024Assignee: Resonac CorporationInventors: Naoto Kawaguchi, Yuji Ito, Masato Fujita, Hirofumi Inoue
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Patent number: 11965035Abstract: The invention relates to an antibody which binds to chondroitin sulfate proteoglycan 5 (CSPG5) or an antibody fragment thereof, a hybridoma which produces the antibody or the antibody fragment thereof, a nucleic acid comprising a nucleotide sequence encoding the antibody or the antibody fragment thereof, a transformant cell comprising a vector comprising the nucleic acid, a method for producing the antibody or the antibody fragment thereof, a composition comprising the antibody or the antibody fragment thereof, and a method for detecting or measuring an antigen present in the brain, a method for diagnosing or treating a brain disease, a method for enhancing the property of accumulating in a brain of an antibody, and a method for increasing the amount of an antibody in the brain, each of which using the antibody or the antibody fragment thereof, and the like.Type: GrantFiled: June 26, 2019Date of Patent: April 23, 2024Assignees: KYOWA KIRIN CO., LTD., KAGOSHIMA UNIVERSITYInventors: Nobuaki Takahashi, Ryosuke Nakano, Sayaka Maeda, Yuji Ito
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Publication number: 20240124577Abstract: The invention relates to an antibody which binds to myelin oligodendrocyte glycoprotein (MOG), an antibody fragment thereof, a hybridoma which produces the antibody or the antibody fragment, a nucleic acid containing a nucleotide sequence which encodes the antibody or the antibody fragment, a transformant cell containing a vector containing the nucleic acid, a method for producing the antibody or the antibody fragment, a composition containing the antibody or the antibody fragment and a method for detecting or measuring an antigen that is present in the brain, a method for diagnosing or treating a brain disease, a method for improving the property of an antibody of accumulating in the brain and a method for increasing the amount of an antibody in the brain which use the antibody or the antibody fragment.Type: ApplicationFiled: August 1, 2023Publication date: April 18, 2024Applicants: Kyowa Kirin Co., Ltd., KAGOSHIMA UNIVERSITYInventors: Nobuaki Takahashi, Ryosuke NAKANO, Sayaka MAEDA, Yuji ITO
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Patent number: 11873337Abstract: The invention relates to an antibody which binds to cell adhesion molecule 3 (CADM3) or an antibody fragment thereof, a hybridoma which produces the antibody or the antibody fragment thereof, a nucleic acid comprising a nucleotide sequence encoding the antibody or the antibody fragment thereof, a transformant cell comprising a vector comprising the nucleic acid, a method for producing the antibody or the antibody fragment thereof, a composition comprising the antibody or the antibody fragment thereof, and a method for detecting or measuring an antigen present in the brain, a method for diagnosing or treating a brain disease, a method for enhancing the property of accumulating in a brain of an antibody, and a method for increasing the amount of an antibody in the brain, each of which using the antibody or the antibody fragment thereof, and the like.Type: GrantFiled: June 26, 2019Date of Patent: January 16, 2024Assignees: KYOWA KIRIN CO., LTD., KAGOSHIMA UNIVERSITYInventors: Nobuaki Takahashi, Ryosuke Nakano, Sayaka Maeda, Takenao Yamada, Yuji Ito
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Publication number: 20230366936Abstract: A lithium ion battery lifetime prediction method executes, by a computer, acquiring training data including cycle measurement data and lifetime data of a battery, learning a lifetime prediction model using the training data with respect to one or more cycle numbers at which a prediction is made, to acquire a set of learned lifetime prediction models corresponding to the cycle numbers at which the prediction is made, respectively, successively acquiring cycle measurement data for prediction of a battery that is a prediction target, up to the cycle numbers at which the prediction is made, respectively, and inputting the cycle measurement data for prediction acquired up to the cycle numbers at which the prediction is made, to the learned lifetime prediction models of the corresponding cycle numbers at which the prediction is made, and acquiring a probability distribution of a lifetime at the cycle numbers at which the prediction is made, respectively, as an output.Type: ApplicationFiled: October 12, 2021Publication date: November 16, 2023Inventors: Yuji KURAUCHI, Takuya MINAMI, Yuji ITO, Daisuke KOHNO, Hirofumi INOUE, Yoshishige OKUNO
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Publication number: 20230294210Abstract: A method of manufacturing a micro-oscillator includes: preparing a substrate having a flat portion and a curved surface portion formed in a three-dimensional curved shape protruding from one surface of the flat portion, the curved surface portion being surrounded by the flat portion; and irradiating an outer surface of the curved surface portion with a laser beam to separate the curved surface portion from the flat portion.Type: ApplicationFiled: March 14, 2023Publication date: September 21, 2023Inventors: YUUKI INAGAKI, YUJI ITO, YUKI ICHIHASHI
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Publication number: 20230234852Abstract: An object of the present invention is to provide carbon-coated Si—C composite particles capable of maintaining a high Si utilization rate and suppressing deterioration of initial coulombic efficiency due to oxidation over time of a lithium-ion secondary battery. The carbon-coated Si—C composite particles of the present invention includes Si—C composite particles containing a carbon material and silicon; and a carbonaceous layer present on surfaces of the Si—C composite particles, wherein the carbon coverage thereof is 70% or more, wherein the BET specific surface area is 200 m2/g or less; wherein R value (ID/IG) is 0.30 or more and 1.10 or less and ISi/IG is 0.15 or less, when the peak attributed to Si is present at 450 to 495 cm?1 and the intensity of the peak is defined as ISi, in Raman spectrum of the carbon-coated Si—C composite particles: and wherein the full width at half maximum of the peak of a 111 plane of Si is 3.00 deg.Type: ApplicationFiled: May 28, 2021Publication date: July 27, 2023Applicant: SHOWA DENKO K.K.Inventors: Masato FUJITA, Yuji ITO, Hirofumi INOUE
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Publication number: 20230231111Abstract: Composite carbon particles including a porous carbon material and a silicon component, the composite carbon particle having an average aspect ratio of 1.25 or less, and a ratio (ISi/IG) of a peak intensity (ISi) in the vicinity of 470 cm?1 to a peak intensity (IG) in the vicinity of 1580 cm?1 as measured by Raman spectroscopy of 0.30 or less, wherein the porous carbon material satisfies V1/V0>0.80 and V2/V0<0.10, when a total pore volume at a maximum value of a relative pressure P/P0 is defined as V0 and P0 is a saturated vapor pressure, a cumulative pore volume at a relative pressure P/P0=0.1 is defined as V1, a cumulative pore volume at a relative pressure P/P0=10?7 is defined as V2 in a nitrogen adsorption test, and has a BET specific surface area of 800 m2/g or more.Type: ApplicationFiled: May 28, 2021Publication date: July 20, 2023Applicant: SHOWA DENKO K.K.Inventors: Takayuki KURITA, Kohei AKIMOTO, Yuji ITO, Hirofumi INOUE, Jinseok BAEK
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Patent number: 11701440Abstract: Described is a labeling technique which can facilitate the metabolism in the liver after administration to patients without the reduction in the antibody function, thereby reducing accumulation of radionuclides in an organ such as the liver, and a modified antibody containing an IgG antibody and an IgG-binding peptide bound to the IgG antibody. The IgG-binding peptide has an amino acid sequence consisting of 13 to 17 amino acid residues, such as GPDCAYH(Xaa1)GELVWCTFH (SEQ ID NO: 2) wherein Xaa1 represents a lysine residue, a cysteine residue, an aspartic acid residue, a glutamic acid residue, 2-aminosuberic acid, or diaminopropionic acid, and a compound represented by the following formula (II-1) is linked at a position of the lysine residue via a modification linker to the N terminus of the IgG-binding peptide.Type: GrantFiled: April 15, 2019Date of Patent: July 18, 2023Assignees: NIHON MEDI-PHYSICS CO., LTD., NATIONAL UNIVERSITY CORPORATION KAGOSHIMA UNIVERSITY, NATIONAL UNIVERSITY CORPORATION CHIBA UNIVERSITYInventors: Shota Komoto, Yu Ogawa, Yoshinari Shoyama, Tadashi Hatano, Yuji Ito, Yasushi Arano, Hiroyuki Suzuki, Tomoya Uehara
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Publication number: 20230223537Abstract: The present invention relates to composite particles containing silicon and carbon, wherein a domain size region of vacancies of 2 nm or less is 44% by volume or more and 70% by volume or less when volume distribution information of domain sizes obtained by fitting a small-angle X-ray scattering spectrum of the composite particles with a spherical model in a carbon-vacancy binary system is accumulated in ascending order, and a true density calculated by dry density measurement by a constant volume expansion method using helium gas is 1.80 g/cm3 or more and 2.20 g/cm3 or less.Type: ApplicationFiled: May 28, 2021Publication date: July 13, 2023Applicant: SHOWA DENKO K.K.Inventors: Naoto KAWAGUCHI, Yuji ITO, Masato FUJITA, Hirofumi INOUE
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Publication number: 20230210967Abstract: A peptide vaccine complexed so that the peptide vaccine can be delivered specifically to the surface of specific immune cells and a method for delivering a peptide vaccine specifically to the surface of specific immune cells. The peptide vaccine is combined with an IgG binding peptide capable of binding to an IgG that is an agonist against molecules on the surface of specific immune cells such as dendritic cells.Type: ApplicationFiled: April 21, 2021Publication date: July 6, 2023Inventors: Yukie SASAKURA, Norihiro NAKAMURA, Yuji MISHIMA, Noriko MATSUMOTO, Fumiko ISODA, Yuji ITO
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Publication number: 20230216025Abstract: An object of the present invention is to provide composite particles capable of suppressing oxidation over time of a Si—C composite material. Composite particles (B) of the present invention contains composite particles (A) containing carbon and silicon; and amorphous layers coating surfaces thereof, where the composite particles (B) have ISi/IG of 0.10 or more and 0.65 or less, and have R value (ID/IG) of 1.00 or more and 1.30 or less, when a peak due to silicon is present at 450 to 495 cm?1, an intensity of the peak is defined as ISi, an intensity of a G band (peak intensity in the vicinity of 1600 cm?1) is defined as IG, and an intensity of a D band (peak intensity in the vicinity of 1360 cm?1) is defined as ID in a Raman spectrum, and where the composite particles (B) have a full width at half maximum of a peak of a 111 plane of Si of 3.0 deg. or more using a Cu-K? ray in an XRD pattern.Type: ApplicationFiled: May 28, 2021Publication date: July 6, 2023Applicant: SHOWA DENKO K.K.Inventors: Akifumi TAKEDA, Masato FUJITA, Yuji ITO, Hirofumi INOUE
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Publication number: 20230207780Abstract: A negative electrode material for a lithium-ion secondary battery containing a composite (C) that contains a porous carbon (A) and a Si-containing compound (B). The porous carbon (A) satisfies V1/V0>0.80 and V2/V0<0.10. When a total pore volume at the maximum value of a relative pressure P/P0 is defined as V0 and P0 is a saturated vapor pressure, a cumulative pore volume at a relative pressure P/P0=0.1 is defined as V1, and a cumulative pore volume at a relative pressure P/P0=10?7 is defined as V2 in a nitrogen adsorption test. Further, the porous carbon (A) has a BET specific surface area of 800 m2/g or more, and the Si-containing compound (B) is contained in pores of the porous carbon (A). Also disclosed is a negative electrode sheet including the negative electrode material and a lithium-ion secondary battery including the negative electrode sheet.Type: ApplicationFiled: May 28, 2021Publication date: June 29, 2023Applicant: SHOWA DENKO K.K.Inventors: Takayuki KURITA, Yuji ITO, Hirofumi INOUE
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Patent number: 11643474Abstract: An object of the present invention is to provide a method by which a peptide having a specific binding capability that can be used for purification of a target molecule can be produced at a low cost, and specifically relates to a peptide fusion protein including one or more peptides having specific binding capability and a scaffold protein, the peptide being inserted into the amino acid sequence of the scaffold protein directly or via a peptide linker, and/or being linked to the N-terminal and/or C-terminal of the scaffold protein.Type: GrantFiled: August 1, 2019Date of Patent: May 9, 2023Assignees: KAGOSHIMA UNIVERSITY, DAICEL CORPORATIONInventors: Yuji Ito, Seiichi Uchimura, Hiromichi Okura
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Publication number: 20230135939Abstract: The present disclosure provides a busbar unit capable of improving the detection accuracy of the temperature of a busbar by a temperature sensor. The busbar unit (10) comprises a busbar (13), a temperature sensor (14), an insulating covering member (7) that is made of resin and covers the busbar (13) and the temperature sensor (14). The temperature sensor (14) has a thermistor element (41) and a case (51) that accommodates the thermistor element (41). The busbar (13) has a sensor holding part (22) that holds the temperature sensor (14). The sensor holding part (22) has a first support part (31) having a first contact surface (31a), a second support part (32) having a second contact surface (32a) facing the first contact surface (31a), and a connection part that connects ends of the first support part (31) and the second support part (32). The sensor holding part (22) holds the temperature sensor (14) by sandwiching the case (51) between the first contact surface (31a) and the second contact surface (32a).Type: ApplicationFiled: July 28, 2020Publication date: May 4, 2023Inventor: Yuji ITO
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Publication number: 20230097871Abstract: The present invention provides a compound represented by formula (I) or a pharmaceutically acceptable salt thereof which has the effect of antagonizing the LPA1 receptor.Type: ApplicationFiled: July 29, 2020Publication date: March 30, 2023Applicant: TAISHO PHARMACEUTICAL CO., LTD.Inventors: Shoichi KURODA, Yuki KOBAYASHI, Kanako HATANAKA, Yuji ITO, Fumito UNEUCHI, Yuko UEHARA