Abstract: A probe unit is a probe unit used to measure hemoglobin dynamics inside a subject, and the probe unit includes a main body having flexibility, a first probe attached to the main body and having a first face from which a first light emitting portion for irradiating the subject with light is exposed, a second probe attached to the main body to face the first probe and having a second face from which a first light incidence portion for detecting light propagated inside the subject is exposed, a first light shielding member having light shielding properties, containing an elastic material, and attached to the first face to surround an emission axis of the first light emitting portion, and a second light shielding member having light shielding properties, containing an elastic material, and attached to the second face to surround an incidence axis of the first light incidence portion.

Abstract: The present invention relates to the phantom comprises water, an oil, an emulsifier and an oil coagulating agent.

Abstract: The present invention relates to the phantom comprises water, an oil, an emulsifier and a water coagulating agent, and having a scattering coefficient of 5 to 20 cm?1 at a wavelength of 750 to 1000 nm.

Abstract: An analysis apparatus includes a light emission unit configured to emit measurement light including light in a 900 nm wavelength band to a sample, a light detection unit configured to acquire spectrum data of reflected light in the sample, a data processing unit configured to perform a noise removing process on the spectrum data, a first determination unit configured to store a PLS regression model associated with prediction of an amount of triglyceride in the sample and to determine an amount of triglyceride in the sample by applying the spectrum data subjected to the noise removing process to the PLS regression model, and a second determination unit configured to store data indicating a correlation with an amount of triglyceride in the sample and to determine an amount of brown adipose tissue or beige fat in the sample based on the data and the amount of triglyceride determined by the first determination unit.

Abstract: A phantom design method includes a correction step and a calculation step. In the correction step, an absorption spectrum of a target of spectroscopic measurement by a near infrared spectrometer is corrected based on a refractive index of the target and a refractive index of a resin used as a base material of a phantom to generate a corrected absorption spectrum. In the calculation step, based on an absorption spectrum of the resin and an absorption spectrum of each of N types of dyes, a concentration of each of the N types of dyes to be contained in the base material is calculated such that an absorption spectrum of the phantom constituted by the base material containing the N types of dyes approximates the corrected absorption spectrum in a predetermined wavelength range of a near infrared region.

Abstract: A phantom design method includes a correction step and a calculation step. In the correction step, an absorption spectrum of a target of spectroscopic measurement by a near infrared spectrometer is corrected based on a refractive index of the target and a refractive index of a resin used as a base material of a phantom to generate a corrected absorption spectrum. In the calculation step, based on an absorption spectrum of the resin and an absorption spectrum of each of N types of dyes, a concentration of each of the N types of dyes to be contained in the base material is calculated such that an absorption spectrum of the phantom constituted by the base material containing the N types of dyes approximates the corrected absorption spectrum in a predetermined wavelength range of a near infrared region.

Abstract: A device for radiating pulsed light toward a thrombus in a blood vessel includes a light source configured to output monitoring light to be radiated into the blood vessel, a light detector configured to detect returned light of the monitoring light and output a detection signal, and a computer configured to acquire a time waveform, which is a change in an intensity of the returned light over time, based on the detection signal, wherein the computer is configured to obtain a parameter on the basis of the time waveform and evaluates a reaction in the blood vessel according to the radiation of the pulsed light on the basis of the parameter.

Abstract: A breast measurement apparatus includes a distance measurement unit measuring a distance from a skin to a light absorption portion for a measurement region of a breast which is a normal region including no tumor or an object region including a tumor, a light measurement unit measuring a hemoglobin amount in the measurement region by a light measurement method using measurement light of a predetermined wavelength, a correlation data storage unit storing normal correlation data of the distance to the light absorption portion and a normal hemoglobin amount generated based on measurement results for normal regions, and an evaluation value calculation unit calculating a property evaluation value of the tumor based on the normal hemoglobin amount, obtained from the normal correlation data and the distance to the light absorption portion in the object region, and an object hemoglobin amount in the object region.

Abstract: The present invention relates to the phantom comprises water, an oil, an emulsifier and a water coagulating agent, and having a scattering coefficient of 5 to 20 cm?1 at a wavelength of 750 to 1000 nm.

Abstract: The present invention relates to the phantom comprises water, an oil, an emulsifier and an oil coagulating agent.

Abstract: A biological measurement device includes a probe including a contact surface that includes a plurality of light input portions that input light to a measurement target part and a plurality of light receiving portions that receive measurement light output from the measurement target part, the contact surface being pressed against the measurement target part, and a calculation unit that calculates internal information on the basis of a result of detecting the measurement light obtained for each combination of the light input portion and the light receiving portion, wherein the plurality of light input portions and the plurality of light receiving portions constitute lattices having an interval d in a first direction and a second direction orthogonal to each other on the contact surface.

Abstract: A method of evaluating a therapeutic effect of a drug in a cancer patient, comprising a comparison step of comparing a first absolute hemoglobin concentration in a sternum portion of the cancer patient before administration of the drug and a second absolute hemoglobin concentration in the sternum portion of the cancer patient after administration of the drug; and an evaluation step of evaluating the therapeutic effect of the drug in the cancer patient based on the result of comparison performed through the comparison step.

Abstract: A device for radiating pulsed light toward a thrombus in a blood vessel includes a light source configured to output monitoring light to be radiated into the blood vessel, a light detector configured to detect returned light of the monitoring light and output a detection signal, and a computer configured to acquire a time waveform, which is a change in an intensity of the returned light over time, based on the detection signal, wherein the computer is configured to obtain a parameter on the basis of the time waveform and evaluates a reaction in the blood vessel according to the radiation of the pulsed light on the basis of the parameter.

Abstract: A mammography device is disclosed. The mammography device includes a container configured to surround the breast and a plurality of optical fibers attached to be directed inward in the container and configured to perform radiation and detection of light. The container has a base member having an opening, a plurality of annular members continuously disposed to come in communication with the opening, and a bottom member disposed inside the annular member spaced the farthest distance from the base member. The annular members and the bottom member are configured to relatively displace the adjacent annular member on the side of the base member or the base member in a communication direction. Some of the plurality of optical fibers is attached to the plurality of annular members.

Abstract: A breast measurement apparatus includes a distance measurement unit measuring a distance from a skin to a light absorption portion for a measurement region of a breast which is a normal region including no tumor or an object region including a tumor, a light measurement unit measuring a hemoglobin amount in the measurement region by a light measurement method using measurement light of a predetermined wavelength, a correlation data storage unit storing normal correlation data of the distance to the light absorption portion and a normal hemoglobin amount generated based on measurement results for normal regions, and an evaluation value calculation unit calculating a property evaluation value of the tumor based on the normal hemoglobin amount, obtained from the normal correlation data and the distance to the light absorption portion in the object region, and an object hemoglobin amount in the object region.

Abstract: A breast measurement apparatus comprises a receptacle for surrounding a breast; a plurality of optical fibers for irradiating the breast with examination light and detecting transmitted scattered light from the breast; an inner image generation unit for generating an optical CT image concerning the breast according to a detection signal of the transmitted scattered light; an ultrasonic probe, arranged so as to face the inside of the receptacle, for scanning the breast with an ultrasonic wave and receiving a reflected wave from the breast; an image generation unit for generating an ultrasonic image concerning the breast according to the reflected wave; and a mechanism for injecting and discharging a liquid interface agent into and from the inside of the receptacle.

Abstract: In measurement data selection, when a vector composed of measurement data obtained for respective combinations of light emitting positions, light detection positions, and resolving times in a time-resolved waveform is given as y, a vector in which pixel values of learning image data are components is given as x, and a system matrix for calculating internal image data from the measurement data is given as A1, the vector y which meets the conditional expressions (2) and (3) min?y?00??(2), ?x?A1Ty?22??2??(3) or the conditional expression (4) min(?y?00+??x?A1Ty?22)??(4) is determined, and upon measurement of a subject, only the measurement data corresponding to nonzero components of the vector y is used to prepare the internal image data.

Abstract: The bioinstrumentation apparatus includes a light irradiation unit irradiating a measurement region with light, a light detection unit detecting diffused light from the measurement region, and a computing unit generating a reconstructed image for the interior of the measurement region. The computing unit calculates J coefficients wj set for every pixel of the reconstructed image and more than 0 and not more than 1 (where J is the number of pixels of the reconstructed image) and carries out successive approximation computation by the following iterative formula xj(k+1)=xj(k)+wjdj(k) (where k is an integer from 1 to N, N is the number of times of iterative computation, xj(k) is a pixel value of the jth pixel on the kth iterative computation, and dj(k) is an update amount of the jth pixel on the kth iterative computation) to generate the reconstructed image.

Abstract: In measurement data selection, when a vector composed of measurement data obtained for respective combinations of light emitting positions, light detection positions, and resolving times in a time-resolved waveform is given as y, a vector in which pixel values of learning image data are components is given as x, and a system matrix for calculating internal image data from the measurement data is given as A1, the vector y which meets the conditional expressions (2) and (3) min?y?00??(2), ?x?A1Ty?22??2??(3) or the conditional expression (4) min(?y?00+??x?A1Ty?22)??(4) is determined, and upon measurement of a subject, only the measurement data corresponding to nonzero components of the vector y is used to prepare the internal image data.

Abstract: A mammography device is disclosed. The mammography device includes a container configured to surround the breast and a plurality of optical fibers attached to be directed inward in the container and configured to perform radiation and detection of light. The container has a base member having an opening, a plurality of annular members continuously disposed to come in communication with the opening, and a bottom member disposed inside the annular member spaced the farthest distance from the base member. The annular members and the bottom member are configured to relatively displace the adjacent annular member on the side of the base member or the base member in a communication direction. Some of the plurality of optical fibers is attached to the plurality of annular members.