Abstract: The invention is concerned with the compounds of formula I: and pharmaceutically acceptable salts and esters thereof, wherein W, X, Y, and R1-R7 are defined in the detailed description and claims. In addition, the present invention relates to methods of manufacturing and using the compounds of formula I as well as pharmaceutical compositions containing such compounds. The compounds of formula I are antagonists or partial agonists at the CRTH2 receptor and may be useful in treating diseases and disorders associated with that receptor such as asthma.

Abstract: A picture encoding and decoding method, a picture encoding and decoding device and a network system are provided, in which, the picture encoding method includes: determining a prediction block used by a picture block according to a division manner of the picture block; determining a corresponding division level in the picture block or the prediction block of transform blocks corresponding to the picture block or the prediction block, in which, the transform blocks corresponding to the picture block or the prediction block include one or more transform blocks; determining a size of the transform blocks corresponding to the picture block or the prediction block according to the division manner of the picture block and the division level; determining identification information for identifying the division level corresponding to the transform blocks corresponding to the picture block or the prediction block; and writing the identification information into a code stream.

Abstract: A method and apparatus for realizing adaptive quantization in the process of image/video coding, which includes the following steps: acquiring the parameter information of the neighbor blocks of the current block; determining the quantization mode of the current block according to the parameter information of the neighbor blocks; and performing quantization processing on transform coefficients of the current block by using the determined quantization mode. Wherein, block coding type and motion vector of the neighbor blocks are used as the parameter information for determining the quantization mode of the current block. An apparatus for adaptive quantization in process of image/video coding is provided. The invention can use different quantization mode for adaptive quantization in different image content of an image sequence, thereby improving the subjective quality of the compressed images at the same bit rate.

Abstract: A compound of formula (I) or a pharmaceutically acceptable salt or ester thereof, wherein A1 to A3 and R1 to R10 have the significance given in claim 1, can be used as a medicament. These compounds are useful in the treatment or prophylaxis of diseases that are related to AMPK regulation, such as obesity, dyslipidemia, hyperglycemia, type 1 or type 2 diabetes and cancers.

Abstract: A method of obtaining a disparity vector and its encoding/decoding in the multi-view coding process is disclosed. The present invention includes essentially: determining a disparity vector between two views during the multi-view image coding, and computing a disparity vector between the other two views according to the disparity vector between the two views and the known relative location information between each of the views. Thereafter, the disparity vector is used for multi-view encoding/decoding. The present invention further makes use of the correlation between the disparity vector and depth information of the spatial vector on one hand, and on the other hand makes use of the direct relationship between the disparity vector and the location of each of the cameras. It is experimentally proved that the disparity vector between several views can be accurately computed during the multi-view coding, thereby improving the performance of multi-view coding.

Abstract: An encoding method with multiple image block division manners is disclosed, including: determining a division manner and a division direction of an image block; dividing the image block to obtain image subblocks sequentially arranged horizontally or vertically; determining whether the image subblocks need subdivision, and if subdivision is not needed, predicting the encoding object in the frame according to the image subblocks, to obtain residual data; performing transformation, quantization, and entropy encoding for the residual data so as to obtain coded residual data; and writing the division manner of the image block, the division direction of the image block, an identifier indicating whether the image subblocks need subdivision, and the coded residual data into a bitstream. By applying the encoding method, better prediction accuracy can be achieved when the image block presents a small change of pixel value in the horizontal or vertical direction.

Abstract: An image interpolation method includes: obtaining pixel values of integer pixel points and/or sub-pixel points in the row, column or any other directions of pixel points; obtaining pre-calculated interpolation coefficients, and interpolating the pixel points. A method for obtaining image interpolation coefficients includes: solving a one-dimensional Wiener-Hopf equation to obtain needed interpolation coefficients in different directions. An image interpolation apparatus performs interpolation filter processing on pixel points by using a first obtaining module, a second obtaining module, and a first calculating module. With the image interpolation method and apparatus, and the method for obtaining interpolation coefficients, the interpolation filter accuracy of the pixel points may be improved, the search accuracy of pixel points may be improved, and thus a more accurate matching block may be obtained in a reference image.

Abstract: The invention is concerned with the compounds of formula I: and pharmaceutically acceptable salts and esters thereof, wherein Q, W, X, R1—R5 and n are defined in the detailed description and claims. In addition, the present invention relates to methods of manufacturing and using the compounds of formula I as well as pharmaceutical compositions containing such compounds. The compounds of formula I are antagonists at the CRTH2 receptor and may be useful in treating diseases and disorders associated with that receptor such as asthma.

Abstract: The present invention relates to a compound of formula (I) as well as pharmaceutically acceptable salt thereof, wherein R1 to R4 have the significance given in claim 1. The compound may be used, for example, for the treatment or prophylaxis of obesity, hyperglycemia, dyslipidemia, and type 1 or type 2 diabetes.

Abstract: An improved gene sequence optimization method, the systematic optimization method, is described for boosting the recombinant expression of genes in bacteria, yeast, insect and mammalian cells. This general method takes into account of multiple, preferably most or all, of the parameters and factors affecting protein expression including codon usage, tRNA usage, GC-content, ribosome binding sequences, promoter, 5?-UTR, ORF and 3?-UTR sequences of the genes to improve and optimize the gene sequences to boost the protein expression of the genes in bacteria, yeast, insect and mammalian cells. In particular, the invention relates to a system and a method for sequence optimization for improved recombinant protein expression using a particle swarm optimization algorithm. The improved systematic optimization method can be incorporated into a software for more efficient optimization.

Abstract: The invention is concerned with the compounds of formula I: and pharmaceutically acceptable salts and esters thereof, wherein Q, R1-R3 and n are defined in the detailed description and claims. In addition, the present invention relates to methods of manufacturing and using the compounds of formula I as well as pharmaceutical compositions containing such compounds. The compounds of formula I are antagonists at the CRTH2 receptor and may be useful in treating diseases and disorders associated with that receptor such as asthma.

Abstract: The invention provides compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with the activity of Cannabinoid Receptor 1 (CB1).

Abstract: A method and apparatus for realizing adaptive quantization in the process of image/video coding, which includes the following steps: acquiring the parameter information of the neighbor blocks of the current block; determining the quantization mode of the current block according to the parameter information of the neighbor blocks; and performing quantization processing on transform coefficients of the current block by using the determined quantization mode. Wherein, block coding type and motion vector of the neighbor blocks are used as the parameter information for determining the quantization mode of the current block. An apparatus for adaptive quantization in process of image/video coding is provided. The invention can use different quantization mode for adaptive quantization in different image content of an image sequence, thereby improving the subjective quality of the compressed images at the same bit rate.

Abstract: The invention is concerned with the compounds of formula I: and pharmaceutically acceptable salts and esters thereof, wherein Q, W, X, R1-R5 and n are defined in the detailed description and claims. In addition, the present invention relates to methods of manufacturing and using the compounds of formula I as well as pharmaceutical compositions containing such compounds. The compounds of formula I are antagonists at the CRTH2 receptor and may be useful in treating diseases and disorders associated with that receptor such as asthma.

Abstract: The invention is concerned with the compounds of formula I: and pharmaceutically acceptable salts and esters thereof, wherein R1-R5, A, B, Q, W, and X are defined in the detailed description and claims. In addition, the present invention relates to methods of manufacturing and using the compounds of formula I as well as pharmaceutical compositions containing such compounds. The compounds of formula I are antagonists at the CRTH2 receptor and may be useful in treating diseases and disorders associated with that receptor such as asthma.

Abstract: The invention is concerned with the compounds of formula I: and pharmaceutically acceptable salts and esters thereof, wherein Q, R1-R3 and n are defined in the detailed description and claims. In addition, the present invention relates to methods of manufacturing and using the compounds of formula I as well as pharmaceutical compositions containing such compounds. The compounds of formula I are antagonists at the CRTH2 receptor and may be useful in treating diseases and disorders associated with that receptor such as asthma.

Abstract: A method and apparatus for realizing adaptive quantization in the process of image/video coding, which includes the following steps: acquiring the parameter information of the neighbor blocks of the current block; determining the quantization mode of the current block according to the parameter information of the neighbor blocks; and performing quantization processing on transform coefficients of the current block by using the determined quantization mode. Wherein, block coding type and motion vector of the neighbor blocks are used as the parameter information for determining the quantization mode of the current block. An apparatus for adaptive quantization in process of image/video coding is provided. The invention can use different quantization mode for adaptive quantization in different image content of an image sequence, thereby improving the subjective quality of the compressed images at the same bit rate.

Abstract: The invention provides compounds having Formula Ia, or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R4 and Y are as defined in the specification; as well as pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with the activity of Cannabinoid Receptor 1 (CB1).

Abstract: The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated TPO activity, particularly diseases or disorders that involve thrombocytopenia.

Abstract: The invention is concerned with the compounds of formula I: and pharmaceutically acceptable salts and esters thereof, wherein Q, W, X, R1-R5 and n are defined in the detailed description and claims. In addition, the present invention relates to methods of manufacturing and using the compounds of formula I as well as pharmaceutical compositions containing such compounds. The compounds of formula I are antagonists at the CRTH2 receptor and may be useful in treating diseases and disorders associated with that receptor such as asthma.