Patents by Inventor Yun Long

Yun Long has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • BENZIMIDAZOLES FOR USE IN THE TREATMENT OF CANCER AND INFLAMMATORY DISEASES
    Publication number: 20180273511
    Abstract: Provided herein are methods for treating, preventing, or ameliorating one or more symptoms of a condition, disorder, or disease mediated by a lipid kinase or a protein kinase with benzimidazoles, for example, of Formula I or II, and pharmaceutical compositions thereof. Also provided herein are benzimidazoles, and pharmaceutical compositions thereof; and methods of their use for treating, preventing, or ameliorating one or more symptoms of a proliferative disease.
    Type: Application
    Filed: September 22, 2016
    Publication date: September 27, 2018
    Inventor: Yun Long
  • Bicyclic heteroarylaminoalkyl phenyl derivatives as PI3K inhibitors
    Patent number: 10077277
    Abstract: This application relates to derivatives of Formula I: and pharmaceutically acceptable salts thereof, which are inhibitors of PI3K, and compositions and methods of treatment related thereto.
    Type: Grant
    Filed: June 10, 2015
    Date of Patent: September 18, 2018
    Assignee: Incyte Corporation
    Inventors: Yun-Long Li, Andrew P. Combs
  • CRYSTALLINE FORMS OF A PI3K INHIBITOR
    Publication number: 20180258105
    Abstract: The present invention is related to crystalline forms of (S)-7-(1-(9H-purin-6-ylamino)ethyl)-6-(3-fluorophenyl)-3-methyl-5H-thiazolo[3,2-a]pyrimidin-5-one which is a PI3K inhibitor useful in the treatment of cancer and other diseases.
    Type: Application
    Filed: May 15, 2018
    Publication date: September 13, 2018
    Inventors: Yun-Long Li, Brian W. Metcalf, Hui-Yin Li
  • Integrated circuit, motor component and application device having the motor component
    Patent number: 10075108
    Abstract: An integrated circuit, a motor component including the integrated circuit and an application device having the motor component are provided according to embodiments of the present disclosure. The integrated circuit includes a housing, an integrated circuit die arranged inside the housing and multiple pins extended out from the housing. The integrated circuit die has a conductive back plate and an electronic circuit arranged on the conductive back plate. The multiple pins include an input pin and an output pin, each of the multiple pins has a lead frame inside the housing. And the conductive back plate is fixed to the lead frame of at least one ungrounded pin of the multiple pins in a manner of electrical insulation, thereby avoiding an short circuit for the integrated circuit due to an electrical connection between the conductive back plate and the lead frame fixed to the conductive back plate.
    Type: Grant
    Filed: August 8, 2016
    Date of Patent: September 11, 2018
    Assignee: Johnson Electric S.A.
    Inventors: Chi Ping Sun, Ken Wong, Shing Hin Yeung, Shu Juan Huang, Yun Long Jiang, Gang Qian, Yue Li, Bao Ting Liu, En Hui Wang, Fei Xin, Xiu Wen Yang, Li Sheng Liu, Yan Yun Cui
  • LACTAM-CONTAINING COMPOUNDS AND DERIVATIVES THEREOF AS FACTOR XA INHIBITORS
    Publication number: 20180244673
    Abstract: The present application describes lactam-containing compounds and derivatives thereof of Formula I: P4—P-M-M4??I or pharmaceutically acceptable salt forms thereof, wherein ring P, if present is a 5-7 membered carbocycle or heterocycle and ring M is a 5-7 membered carbocycle or heterocycle. Compounds of the present invention are useful as inhibitors of trypsin-like serine proteases, specifically factor Xa.
    Type: Application
    Filed: April 30, 2018
    Publication date: August 30, 2018
    Inventors: Donald J.P. Pinto, Mimi L. Quan, Michael J. Orwat, Yun-Long Li, Wei Han, Jennifer X. Qiao, Patrick Y.S. Lam, Stephanie L. Koch
  • Pharmaceutical compositions to reduce complications of ocular steroid
    Patent number: 10058616
    Abstract: The present invention relates to pharmaceutical compositions comprising a combination of a lipid cake mixture comprising one or more phospholipids, with or without cholesterol, and a steroid solution comprising an ocular steroid, derivative thereof a pharmaceutically acceptable salt thereof or a prodrug thereof, wherein the total amount of the phospholipid in the said composition is about 0.1 umol to less than about 2.5 umol per 50 ul of pharmaceutical composition and the side effects of the ocular steroid are reduced. The pharmaceutical composition is preferably administered by ocular route to treat ophthalmic diseases.
    Type: Grant
    Filed: February 8, 2013
    Date of Patent: August 28, 2018
    Assignees: TLC BIOPHARMACEUTICALS, INC., TAIWAN LIPOSOME COMPANY, LTD.
    Inventors: Keelung Hong, Luke S. S. Guo, Sheue-Fang Shih, Po-Chun Chang, Chih-Chiang Tsai, Hong-Hul Lin, Yun-Long Tseng
  • Pyrrolopyrimidine derivatives as TAM inhibitors
    Patent number: 10053465
    Abstract: This application relates to compounds of Formula I: or pharmaceutically acceptable salts thereof, which are inhibitors of TAM kinases which are useful for the treatment of disorders such as cancer.
    Type: Grant
    Filed: August 25, 2016
    Date of Patent: August 21, 2018
    Assignee: Incyte Corporation
    Inventors: Yun-Long Li, David M. Burns, Hao Feng, Joseph Glenn, Chunhong He, Taisheng Huang, Song Mei, Jun Pan, Xiaozhao Wang, Yingda Ye
  • MAGNETIC SENSOR AND AN INTEGRATED CIRCUIT
    Publication number: 20180234041
    Abstract: The present teaching relates to a method/apparatus for a magnetic sensor. The apparatus of the magnetic sensor resides in a housing and includes an input port and an output port, both extending from the housing. The apparatus also includes an electrical circuit which comprises a magnetic field detecting circuit, configured to detect an external magnetic field and output a magnetic induction signal that is indicative of information related to the external magnetic field, an output control circuit coupled between the magnetic field detecting circuit and the output port, and a state control circuit coupled with the output control circuit and configured to determine whether a predetermined condition is satisfied and signal the same to the output control circuit.
    Type: Application
    Filed: April 9, 2018
    Publication date: August 16, 2018
    Inventors: Chi Ping SUN, Fei XIN, Ken WONG, Shing Hin YEUNG, Hui Min GUO, Shu Zuo LOU, Xiao Ming CHEN, Guang Jie CAI, Chun Fai WONG, Shu Juan HUANG, Yun Long JIANG, Yue LI, Bao Ting LIU, En Hui WANG, Xiu Wen YANG, Li Sheng LIU, Yan Yun CUI
  • PHARMACEUTICAL COMPOSITIONS TO REDUCE COMPLICATIONS OF OCULAR STEROID
    Publication number: 20180193461
    Abstract: The present invention relates to pharmaceutical compositions comprising a combination of a lipid cake mixture comprising one or more phospholipids, with or without cholesterol, and a steroid solution comprising an ocular steroid, derivative thereof, a pharmaceutically acceptable salt thereof or a prodrug thereof, wherein the total amount of the phospholipid in the said composition is about 0.1 umol to less than about 2.5 umol per 50 ul of pharmaceutical composition and the side effects of the ocular steroid are reduced. The pharmaceutical composition is preferably administered by ocular route to treat ophthalmic diseases.
    Type: Application
    Filed: March 6, 2018
    Publication date: July 12, 2018
    Inventors: Keelung Hong, Luke S. S. Guo, Sheue-Fang Shih, Po-Chun Chang, Chih-Chiang Tsai, Hong-Hul Lin, Yun-Long Tseng
  • THIAZOLECARBOXAMIDES AND PYRIDINECARBOXAMIDE COMPOUNDS USEFUL AS PIM KINASE INHIBITORS
    Publication number: 20180193323
    Abstract: The present disclosure describes thiazole and pyridine carboxamide derivatives, their compositions and methods of use. The compounds inhibit the activity of the Pim kinases and are useful in the treatment of diseases related to the activity of Pim kinases including, e.g., cancer and other diseases.
    Type: Application
    Filed: November 16, 2017
    Publication date: July 12, 2018
    Inventors: Chu-Biao Xue, Yun-Long Li, Hao Feng, Jun Pan, Anlai Wang, Ke Zhang, Wenqing Yao, Fenglei Zhang, Jincong Zhuo
  • Benzimidazole derivatives as ERBB tyrosine kinase inhibitors for the treatment of cancer
    Patent number: 10005765
    Abstract: Provided herein are benzimidazole derivatives, for example, of Formula I, and pharmaceutical compositions thereof. Also provided herein are methods of their use for treating, preventing, or ameliorating one or more symptoms of a proliferative disease.
    Type: Grant
    Filed: March 19, 2015
    Date of Patent: June 26, 2018
    Assignee: Capella Therapeutics, Inc.
    Inventor: Yun Long
  • Bicyclic fused pyrimidine compounds as TAM inhibitors
    Patent number: 10005788
    Abstract: This application relates to compounds of Formula I: or pharmaceutically acceptable salts thereof, which are inhibitors of TAM kinases which are useful for the treatment of disorders such as cancer.
    Type: Grant
    Filed: June 16, 2017
    Date of Patent: June 26, 2018
    Assignee: Incyte Corporation
    Inventors: Yun-Long Li, David M. Burns
  • Ophthalmic Drug Delivery System Containing Phospholipid and Cholesterol
    Publication number: 20180169248
    Abstract: An ophthalmic drug delivery system that contains phospholipid and cholesterol for prolonging drug lifetime in the eyes.
    Type: Application
    Filed: February 5, 2018
    Publication date: June 21, 2018
    Inventors: SHEUE-FANG SHIH, PO-CHUN CHANG, YUN-LONG TSENG, LUKE S.S. GUO, KEELUNG HONG
  • Furo- and thieno-pyridine carboxamide compounds useful as pim kinase inhibitors
    Patent number: 10000507
    Abstract: The present disclosure describes furo- and thieno-pyridine carboxamide compounds, as well as their compositions and methods of use. The compounds inhibit the activity of the Pim kinases, and are useful in the treatment of diseases related to the activity of Pim kinases including, e.g., cancer and other diseases.
    Type: Grant
    Filed: December 15, 2016
    Date of Patent: June 19, 2018
    Assignee: Incyte Corporation
    Inventors: Yun-Long Li, David M. Burns, Hao Feng, Taisheng Huang, Song Mei, Jun Pan, Hai-Fen Ye, Wenyu Zhu, Maria Rafalski, Anlai Wang, Chu-Biao Xue
  • Ophthalmic drug delivery system containing phospholipid and cholesterol
    Patent number: 9987360
    Abstract: An ophthalmic drug delivery system that contains phospholipid and cholesterol for prolonging drug lifetime in the eyes.
    Type: Grant
    Filed: December 16, 2014
    Date of Patent: June 5, 2018
    Assignees: TAIWAN LIPOSOME CO. LTD., TLC BIOPHARMACEUTICALS, INC.
    Inventors: Sheue-Fang Shih, Po-Chun Chang, Yun-Long Tseng, Luke S. S. Guo, Keelung Hong
  • Crystalline forms of a PI3K inhibitor
    Patent number: 9988401
    Abstract: The present invention is related to crystalline forms of (S)-7-(1-(9H-purin-6-ylamino) ethyl)-6-(3-fluorophenyl)-3-methyl-5H-thiazolo[3,2-a]pyrimidin-5-one which is a PI3K inhibitor useful in the treatment of cancer and other diseases.
    Type: Grant
    Filed: May 10, 2016
    Date of Patent: June 5, 2018
    Assignee: Incyte Corporation
    Inventors: Yun-Long Li, Brian W. Metcalf, Hui-Yin Li
  • TRICYCLIC FUSED THIOPHENE DERIVATIVES AS JAK INHIBITORS
    Publication number: 20180148460
    Abstract: The present invention provides tricyclic fused thiophene derivatives, as well as their compositions and methods of use, that modulate the activity of Janus kinase (JAK) and are useful in the treatment of diseases related to the activity of JAK including, for example, inflammatory disorders, autoimmune disorders, cancer, and other diseases.
    Type: Application
    Filed: January 18, 2018
    Publication date: May 31, 2018
    Inventors: Yun-Long Li, Wenyu Zhu, Song Mei, Joseph Glenn
  • Pyrrolotriazine compounds as tam inhibitors
    Patent number: 9981975
    Abstract: This application relates to compounds of Formula I: or pharmaceutically acceptable salts thereof, which are inhibitors of TAM kinases which are useful for the treatment of disorders such as cancer.
    Type: Grant
    Filed: March 27, 2017
    Date of Patent: May 29, 2018
    Assignee: Incyte Corporation
    Inventors: Yun-Long Li, Xiaozhao Wang, Chunhong He
  • Pyrimidinones as PI3K inhibitors
    Patent number: 9975907
    Abstract: The present invention provides pyrimidinones that modulate the activity of phosphoinositide 3-kinases (PI3Ks) and are useful in the treatment of diseases related to the activity of PI3Ks including, for example, inflammatory disorders, immune-based disorders, cancer, and other diseases.
    Type: Grant
    Filed: July 27, 2016
    Date of Patent: May 22, 2018
    Assignees: Incyte Holdings Corporation, Incyte Corporation
    Inventors: Yun-Long Li, Brian W. Metcalf, Andrew P. Combs
  • Magnetic sensor and an integrated circuit
    Patent number: 9973121
    Abstract: The present teaching relates to a magnetic sensor residing in a housing. The magnetic sensor includes an input port and an output port, both extending from the housing, wherein the input port is to be connected to an external alternating current (AC) power supply. The magnetic sensor also includes an electric circuit which comprises an output control circuit coupled with the output port and configured to be at least responsive to a magnetic induction signal and the external AC power supply to control the magnetic sensor to operate in a state in which a load current flows through the output port. The magnetic induction signal is indicative of at least one characteristic of an external magnetic field detected by the electrical circuit and the operating frequency of the magnetic sensor is positively proportional to the frequency of the external AC power supply.
    Type: Grant
    Filed: August 8, 2016
    Date of Patent: May 15, 2018
    Assignee: JOHNSON ELECTRIC S.A.
    Inventors: Chi Ping Sun, Fei Xin, Ken Wong, Shing Hin Yeung, Hui Min Guo, Shu Zuo Lou, Xiao Ming Chen, Guang Jie Cai, Chun Fai Wong, Shu Juan Huang, Yun Long Jiang, Yue Li, Bao Ting Liu, En Hui Wang, Xiu Wen Yang, Li Sheng Liu, Yan Yun Cui