Patents by Inventor Yun Long

Yun Long has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • HETEROCYCLYLAMINES AS PI3K INHIBITORS
    Publication number: 20190298724
    Abstract: The present invention provides heterocyclylamine derivatives of Formula I: wherein the variables are defined herein, that modulate the activity of phosphoinositide 3-kinases (PI3Ks) and are useful in the treatment of diseases related to the activity of PI3Ks including, for example, inflammatory disorders, immune-based disorders, cancer, and other diseases.
    Type: Application
    Filed: June 19, 2019
    Publication date: October 3, 2019
    Inventors: Richard B. Sparks, Andrew P. Combs, Brent Douty, Yun-Long Li, Song Mei, Eddy W. Yue
  • Pyrimidinones as PI3K inhibitors
    Patent number: 10428087
    Abstract: The present invention provides pyrimidinones that modulate the activity of phosphoinositide 3-kinases (PI3Ks) and are useful in the treatment of diseases related to the activity of PI3Ks including, for example, inflammatory disorders, immune-based disorders, cancer, and other diseases.
    Type: Grant
    Filed: April 23, 2018
    Date of Patent: October 1, 2019
    Assignees: Incyte Corporation, Incyte Holdings Corporation
    Inventors: Yun-Long Li, Brian W. Metcalf, Andrew P. Combs
  • METHODS OF TREATING ARTHRITIS
    Publication number: 20190290583
    Abstract: The present invention provides methods of treating arthritis. A sustained release composition comprising liposomes and one or more therapeutic agent or a pharmaceutically acceptable salt thereof is administered to a subject in need thereof. The liposomes may be in an aqueous suspension. The sustained release composition can be administered intraarticularly.
    Type: Application
    Filed: June 12, 2019
    Publication date: September 26, 2019
    Inventors: KEELUNG HONG, LUKE S. S. GUO, YUN-LONG TSENG, SHEUE-FANG SHIH, PO-CHUN CHANG, CHIH-CHIANG TSAI, HONG-HUI LIN
  • Pharmaceutical compositions of hydrophobic camptothecin derivatives
    Patent number: 10391056
    Abstract: The present invention provides a pharmaceutical composition comprising at least one hydrophobic camptothecin derivative or a pharmaceutically acceptable salt of said derivative and a polyethylene glycol (PEG) conjugated phospholipid. Also provided is a method to inhibit cancer cells in a subject in need thereof by administering the pharmaceutical composition of the present invention.
    Type: Grant
    Filed: November 2, 2012
    Date of Patent: August 27, 2019
    Assignees: Taiwan Lipsome Company, LTD., TLC Biopharmaceuticals, Inc.
    Inventors: Pei Kan, ChiaHung Hung, KeeIung Hong, Yun-Long Tseng, Yung-Hsu Chan
  • Blowing system with expandable functions, expansion device, and operating method
    Patent number: 10378783
    Abstract: The disclosure is related to a blowing apparatus with expandable functions, an expansion device, and an operating method. The blowing apparatus has an electrical interface used to connect one of the expansion devices with various functions. The blowing apparatus has a control unit used to identify an operating mode of the expansion device connected with the blowing apparatus. A control signal is therefore generated. According to the control signal, the control unit controls rotating speed of a fan unit and a heating temperature of a heating unit. The expansion device can be disposed with a mist unit having a container and a mist generating unit. The mist unit sprays the mist to an outlet cap of the expansion device. The blowing apparatus then blows the mist out of the outlet cap by means of the rotating speed of fan unit and the temperature of heating unit.
    Type: Grant
    Filed: September 9, 2016
    Date of Patent: August 13, 2019
    Assignee: JIYONSON CO., LTD.
    Inventor: Yun-Long Tun
  • Heterocyclylamines as PI3K inhibitors
    Patent number: 10376513
    Abstract: The present invention provides heterocyclylamine derivatives of Formula I: wherein the variables are defined herein, that modulate the activity of phosphoinositide 3-kinases (PI3Ks) and are useful in the treatment of diseases related to the activity of PI3Ks including, for example, inflammatory disorders, immune-based disorders, cancer, and other diseases.
    Type: Grant
    Filed: August 24, 2018
    Date of Patent: August 13, 2019
    Assignees: Incyte Holdings Corporation, Incyte Corporation
    Inventors: Richard B. Sparks, Andrew P. Combs, Brent Douty, Yun-Long Li, Song Mei, Eddy W. Yue
  • Tricyclic fused thiophene derivatives as JAK inhibitors
    Patent number: 10370387
    Abstract: The present invention provides tricyclic fused thiophene derivatives, as well as their compositions and methods of use, that modulate the activity of Janus kinase (JAK) and are useful in the treatment of diseases related to the activity of JAK including, for example, inflammatory disorders, autoimmune disorders, cancer, and other diseases.
    Type: Grant
    Filed: January 18, 2018
    Date of Patent: August 6, 2019
    Assignees: Incyte Holdings Corporation, Incyte Corporation
    Inventors: Yun-Long Li, Wenyu Zhu, Song Mei
  • Ring binder mechanism
    Patent number: 10369833
    Abstract: A ring mechanism has an elongate housing and rings for holding loose-leaf pages. Each ring has ring members mounted on pivoting hinge plates for movement between open and closed positions. An actuator has opening and closing arms extending from an actuator body for opening and closing the rings. The mechanism has a travel bar moveable between a locked position in which a locking element blocks pivoting movement of the hinge plates and an unlocked position. The actuator has a flexible arm positioned to push the travel bar toward the locked position when the actuator closes the rings. At least a portion of the flexible arm is adapted to deform during closing in a manner that includes rotation in a first direction relative to the body of the actuator. Movement of the actuator to close the rings includes rotation of the actuator in the first direction relative to the housing.
    Type: Grant
    Filed: May 6, 2015
    Date of Patent: August 6, 2019
    Assignee: World Wide Stationery Mfg. Co., Ltd.
    Inventors: Ming Hua Huang, Yun Long Li
  • CONTROLLED DRUG RELEASE LIPOSOME COMPOSITIONS AND METHODS THEREOF
    Publication number: 20190216932
    Abstract: The present invention relates to pharmaceutical compositions comprising at least one liposome, at least one polyvalent counterion donor or a pharmaceutically acceptable salt thereof, at least one monovalent counterion donor or a pharmaceutically acceptable salt thereof, and an amphipathic therapeutic agent or a derivative or pharmaceutically acceptable salt thereof. The present invention also relates to methods of inhibiting cancer cell growth while reducing toxicity, comprising administering the pharmaceutical composition described herein.
    Type: Application
    Filed: January 7, 2019
    Publication date: July 18, 2019
    Applicants: TAIWAN LIPOSOME COMPANY, LTD., TLC BIOPHARMACEUTICALS, INC.
    Inventors: Pei KAN, Yun-Long TSENG, Han-Chun OU, Chun-yen LAI
  • Pharmaceutical compositions to reduce complications of ocular steroid
    Patent number: 10350294
    Abstract: The present invention relates to pharmaceutical compositions comprising a combination of a lipid cake mixture comprising one or more phospholipids, with or without cholesterol, and a steroid solution comprising an ocular steroid, derivative thereof, a pharmaceutically acceptable salt thereof or a prodrug thereof, wherein the total amount of the phospholipid in the said composition is about 0.1 umol to less than about 2.5 umol per 50 ul of pharmaceutical composition and the side effects of the ocular steroid are reduced. The pharmaceutical composition is preferably administered by ocular route to treat ophthalmic diseases.
    Type: Grant
    Filed: March 6, 2018
    Date of Patent: July 16, 2019
    Assignees: TAIWAN LIPOSOME COMPANY, LTD., TLC BIOPHARMACEUTICALS, INC.
    Inventors: Keelung Hong, Luke S. S. Guo, Sheue-Fang Shih, Po-Chun Chang, Chih-Chiang Tsai, Hong-Hul Lin, Yun-Long Tseng
  • THIAZOLECARBOXAMIDES AND PYRIDINECARBOXAMIDE COMPOUNDS USEFUL AS PIM KINASE INHIBITORS
    Publication number: 20190209537
    Abstract: The present disclosure describes thiazole and pyridine carboxamide derivatives, their compositions and methods of use. The compounds inhibit the activity of the Pim kinases and are useful in the treatment of diseases related to the activity of Pim kinases including, e.g., cancer and other diseases.
    Type: Application
    Filed: March 11, 2019
    Publication date: July 11, 2019
    Inventors: Chu-Biao Xue, Yun-Long Li, Hao Feng, Jun Pan, Anlai Wang, Ke Zhang, Wenqing Yao, Fenglei Zhang, Jincong Zhuo
  • SALTS OF (S)-7-(1-(9H-PURIN-6-YLAMINO)ETHYL)-6-(3-FLUOROPHENYL)-3-METHYL-5H-THIAZOLO[3,2-A]PYRIMIDIN-5-ONE
    Publication number: 20190202840
    Abstract: The present invention relates to salt forms of the phosphoinositide 3-kinase (PI3K) inhibitor (S)-7-(1-(9H-purin-6-ylamino)ethyl)-6-(3-fluorophenyl)-3-methyl-5H-thiazolo[3,2-a]pyrimidin-5-one, pharmaceutical compositions comprising the same, and methods of using the salts and compositions for the treatment of PI3K-associated diseases such as cancer.
    Type: Application
    Filed: March 7, 2019
    Publication date: July 4, 2019
    Inventors: Yun-Long Li, Brian W. Metcalf, Hui-Yin Li
  • Methods of treating arthritis
    Patent number: 10322086
    Abstract: The present invention provides methods of treating arthritis. A sustained release composition comprising liposomes and one or more therapeutic agent or a pharmaceutically acceptable salt thereof is administered to a subject in need thereof. The liposomes may be in an aqueous suspension. The sustained release composition can be administered intraarticularly.
    Type: Grant
    Filed: September 5, 2017
    Date of Patent: June 18, 2019
    Assignees: TLC BIOPHARMACEUTICALS, INC., TAIWAN LIPOSOME COMPANY, LTD.
    Inventors: Keelung Hong, Luke S. S. Guo, Yun-Long Tseng, Sheue-Fang Shih, Po-Chun Chang, Chih-Chiang Tsai, Hong-Hui Lin
  • BENZIMIDAZOLE DERIVATIVES AS ERBB TYROSINE KINASE INHIBITORS FOR THE TREATMENT OF CANCER
    Publication number: 20190169204
    Abstract: Provided herein are benzimidazole derivatives, for example, of Formula (I), and pharmaceutical compositions thereof. Also provided herein are methods of their use for treating, preventing, or ameliorating one or more symptoms of a proliferative disease.
    Type: Application
    Filed: February 7, 2019
    Publication date: June 6, 2019
    Inventor: Yun Long
  • DART HAVING A LATCHED STABILIZER FOR BLOWGUN
    Publication number: 20190154419
    Abstract: A dart for a blowgun is provided with a hollow main shaft; a head releasably secured to a front end of the hollow main shaft; and a stabilizer formed with a rear portion of the hollow main shaft and including a plurality of flexible latches and a plurality of gaps each disposed between two adjacent flexible latches. The latches may expand or contract to be in a minimum friction contact with an inner wall of a blowgun in a launching operation.
    Type: Application
    Filed: November 19, 2018
    Publication date: May 23, 2019
    Inventor: Yun-Long KUO
  • Electronic device and magnetic sensor integrated circuit
    Patent number: 10295371
    Abstract: An electronic device and a magnetic sensor integrated circuit thereof are provided. The magnetic sensor integrated circuit includes a shell, a semiconductor substrate installed in the shell and a first to a third port extending from the shell. A rectifier and a position sensor are provided on the semiconductor substrate. The rectifier includes first and second output terminals and two input terminals respectively connected to the first and second ports. In a case that the first and second ports are positively or negatively connected to an external power supply, a voltage output by the first output terminal of the rectifier is higher than the voltage output by the second output terminal of the rectifier. The position sensor is connected to the first and second output terminals of the rectifier, and a magnetic field signal detected by the position sensor is output by the third port.
    Type: Grant
    Filed: August 8, 2016
    Date of Patent: May 21, 2019
    Assignee: JOHNSON ELECTRIC INTERNATIONAL AG
    Inventors: Chi Ping Sun, Fei Xin, Ken Wong, Shing Hin Yeung, Shu Juan Huang, Yun Long Jiang, Yue Li, Bao Ting Liu, En Hui Wang, Xiu Wen Yang, Li Sheng Liu, Yan Yun Cui
  • ASSISTING APPARATUS FOR BEAN ROASTING AND BEAN ROASTING APPARATUS
    Publication number: 20190142054
    Abstract: An assisting apparatus for bean roasting and a bean roasting apparatus are provided. The present invention senses sound in a chamber of a bean roasting device through a microphone to generate an audio signal, and control the bean roasting procedure by determining that the energy value of the audio signal crosses a threshold at a time point based on the observation time window.
    Type: Application
    Filed: November 16, 2018
    Publication date: May 16, 2019
    Inventors: Yun-Long TUN, Chia-Yen LIU, Yi-Chi LIN
  • ASSISTING APPARATUS FOR BEAN ROASTING AND BEAN ROASTING APPARATUS
    Publication number: 20190142053
    Abstract: An assisting apparatus for bean roasting and a bean roasting apparatus are provided. The assisting apparatus captures a scene in a chamber of the bean roasting device through an image capturing device to generate an image, compares the image with a historical roasting pattern set based on a plurality of color attributes of a color space to determine a roasting level represented by the image, and controls the bean roasting procedure.
    Type: Application
    Filed: November 16, 2018
    Publication date: May 16, 2019
    Inventors: Yun-Long TUN, Chia-Yen LIU, Yi-Chi LIN
  • Pharmaceutical compositions to reduce complications of ocular steroid
    Patent number: 10286076
    Abstract: The present invention relates to pharmaceutical compositions comprising a combination of a lipid cake mixture comprising one or more phospholipids, with or without cholesterol, and a steroid solution comprising an ocular steroid, derivative thereof, a pharmaceutically acceptable salt thereof or a prodrug thereof, wherein the total amount of the phospholipid in the said composition is about 0.1 umol to less than about 2.5 umol per 50 ul of pharmaceutical composition and the side effects of the ocular steroid are reduced. The pharmaceutical composition is preferably administered by ocular route to treat ophthalmic diseases.
    Type: Grant
    Filed: March 6, 2018
    Date of Patent: May 14, 2019
    Assignees: TAIWAN LIPOSOME COMPANY, LTD., TLC BIOPHARMACEUTICALS, INC.
    Inventors: Keelung Hong, Luke S. S. Guo, Sheue-Fang Shih, Po-Chun Chang, Chih-Chiang Tsai, Hong-Hul Lin, Yun-Long Tseng
  • HETEROCYCLYLAMINES AS PI3K INHIBITORS
    Publication number: 20190134040
    Abstract: The present invention provides heterocyclylamine derivatives of Formula I: wherein the variables are defined herein, that modulate the activity of phosphoinositide 3-kinases (PI3Ks) and are useful in the treatment of diseases related to the activity of PI3Ks including, for example, inflammatory disorders, immune-based disorders, cancer, and other diseases.
    Type: Application
    Filed: August 24, 2018
    Publication date: May 9, 2019
    Inventors: Yun-Long Li, Wenqing Yao, Andrew P. Combs, Eddy W. Yue, Song Mei, Wenyu Zhu, Joseph Glenn, Thomas P. Maduskuie, JR., Richard B. Sparks, Brent Douty, Chunhong He