Patents by Inventor Yun Long

Yun Long has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Heterocyclylamines as PI3K inhibitors
    Patent number: 10646492
    Abstract: The present invention provides heterocyclylamine derivatives of Formula I: wherein the variables are defined herein, that modulate the activity of phosphoinositide 3-kinases (PI3Ks) and are useful in the treatment of diseases related to the activity of PI3Ks including, for example, inflammatory disorders, immune-based disorders, cancer, and other diseases.
    Type: Grant
    Filed: June 19, 2019
    Date of Patent: May 12, 2020
    Assignees: Incyte Corporation, Incyte Holdings Corporation
    Inventors: Yun-Long Li, Wenqing Yao, Andrew P. Combs, Song Mei, Joseph Glenn, Thomas P. Maduskuie, Jr., Richard B. Sparks
  • Benzimidazole derivatives as ERBB tyrosine kinase inhibitors for the treatment of cancer
    Patent number: 10647707
    Abstract: Provided herein are benzimidazole derivatives, for example, of Formula I, and pharmaceutical compositions thereof. Also provided herein are methods of their use for treating, preventing, or ameliorating one or more symptoms of a proliferative disease.
    Type: Grant
    Filed: June 11, 2018
    Date of Patent: May 12, 2020
    Assignee: Capella Therapeutics, Inc.
    Inventor: Yun Long
  • LACTAM-CONTAINING COMPOUNDS AND DERIVATIVES THEREOF AS FACTOR XA INHIBITORS
    Publication number: 20200140436
    Abstract: The present application describes lactam-containing compounds and derivatives thereof of Formula I: P4-P-M-M4?? I or pharmaceutically acceptable salt forms thereof, wherein ring P, if present is a 5-7 membered carbocycle or heterocycle and ring M is a 5-7 membered carbocycle or heterocycle. Compounds of the present invention are useful as inhibitors of trypsin-like serine proteases, specifically factor Xa.
    Type: Application
    Filed: January 8, 2020
    Publication date: May 7, 2020
    Inventors: Donald J.P. Pinto, Mimi L. Quan, Michael J. Orwat, Yun-Long Li, Wei Han, Jennifer X. Qiao, Patrick Y.S. Lam, Stephanie L. Koch
  • Fabric pretreatment for digital printing
    Patent number: 10640917
    Abstract: An aqueous blend of an azetidinium functionalized polymer and a polymer having quaternary amine groups is disclosed for use as aqueous pretreatment for substrates such as textiles and garments that are going to be digitally printed. The pretreatment may further comprise wetting agents, surfactants, and preservatives. The pretreatment may be dry or wet immediately prior to digital printing and may be heat treated to bond the pretreatment to the substrate and/or the subsequent print ink.
    Type: Grant
    Filed: November 20, 2014
    Date of Patent: May 5, 2020
    Assignee: LUBRIZOL ADVANCED MATERIALS, INC.
    Inventors: Yun-Long Pan, Gary A. Anderle, Stacy L. Rohde
  • PYRROLOTRIAZINE COMPOUNDS AS TAM INHIBITORS
    Publication number: 20200131185
    Abstract: This application relates to compounds of Formula I: or pharmaceutically acceptable salts thereof, which are inhibitors of TAM kinases which are useful for the treatment of disorders such as cancer.
    Type: Application
    Filed: September 4, 2019
    Publication date: April 30, 2020
    Inventors: Yun-Long Li, Xiaozhao Wang, Chunhong He
  • Magnetic sensor integrated circuit, motor component and application apparatus
    Patent number: 10637374
    Abstract: A magnetic sensor integrated circuit, a motor component and an application apparatus are provided. The integrated circuit includes: an input port, an output port, a magnetic field detection circuit and an output control circuit. The magnetic field detection circuit detects an external magnetic field and outputs magnetic field detection information. The output control circuit enables, at least based on the magnetic field detection information, the integrated circuit to switch at least between a first state, in which a current flows from the output port to an outside of the integrated circuit, and a second state, in which a current flows from the outside of the integrated circuit to the output port.
    Type: Grant
    Filed: August 8, 2016
    Date of Patent: April 28, 2020
    Assignee: JOHNSON ELECTRIC INTERNATIONAL AG
    Inventors: Chi Ping Sun, Fei Xin, Ken Wong, Shing Hin Yeung, Shu Juan Huang, Yun Long Jiang, Yue Li, Bao Ting Liu, En Hui Wang, Xiu Wen Yang, Li Sheng Liu, Yan Yun Cui
  • PYRIMIDINONES AS PI3K INHIBITORS
    Publication number: 20200123176
    Abstract: The present invention provides pyrimidinones that modulate the activity of phosphoinositide 3-kinases (PI3Ks) and are useful in the treatment of diseases related to the activity of PI3Ks including, for example, inflammatory disorders, immune-based disorders, cancer, and other diseases.
    Type: Application
    Filed: August 20, 2019
    Publication date: April 23, 2020
    Inventors: Yun-Long Li, Brian W. Metcalf, Andrew P. Combs
  • OPERATING METHOD OF INTERACTIVE TOUCH DISPLAY SYSTEM
    Publication number: 20200104009
    Abstract: An operating method of interactive touch display system includes following steps. Step 1 is for executing a scanning process, which is scanning whether at least one object is in a predetermined region in accordance with a camera or not, then calculating to obtain the number of the object if the result is yes (or true). Step 2 is for executing a drawing process in accordance with the number of the object, which is calculating the position of the at least one object to display at least one toolbox corresponding to the at least one object on an interactive display. Wherein the number of the toolbox is equal to the number of the object, and the position of the interactive display of each toolbox corresponds to the position of the predetermined region of each corresponding object.
    Type: Application
    Filed: September 18, 2019
    Publication date: April 2, 2020
    Inventors: Po-Cheng Chen, Yun-Long Sie
  • Benzimidazoles for use in the treatment of cancer and inflammatory diseases
    Patent number: 10590108
    Abstract: Provided herein are methods for treating, preventing, or ameliorating one or more symptoms of a condition, disorder, or disease mediated by a lipid kinase or a protein kinase with benzimidazoles, for example, of Formula I or II, and pharmaceutical compositions thereof. Also provided herein are benzimidazoles, and pharmaceutical compositions thereof; and methods of their use for treating, preventing, or ameliorating one or more symptoms of a proliferative disease.
    Type: Grant
    Filed: September 22, 2016
    Date of Patent: March 17, 2020
    Assignee: CAPELLA THERAPEUTICS, INC.
    Inventor: Yun Long
  • TRICYCLIC FUSED THIOPHENE DERIVATIVES AS JAK INHIBITORS
    Publication number: 20200040002
    Abstract: The present invention provides tricyclic fused thiophene derivatives, as well as their compositions and methods of use, that modulate the activity of Janus kinase (JAK) and are useful in the treatment of diseases related to the activity of JAK including, for example, inflammatory disorders, autoimmune disorders, cancer, and other diseases.
    Type: Application
    Filed: June 27, 2019
    Publication date: February 6, 2020
    Inventors: Yun-Long Li, Wenyu Zhu, Song Mei, Joseph Glenn
  • BIPYRAZOLE DERIVATIVES AS JAK INHIBITORS
    Publication number: 20200010456
    Abstract: The present invention provides compounds of Formula I: or pharmaceutically acceptable salts thereof, as well as their compositions and methods of use, that inhibit the activity of Janus kinase (JAK) and are useful in the treatment of diseases related to the activity of JAK including, for example, inflammatory disorders, autoimmune disorders, cancer, and other diseases.
    Type: Application
    Filed: August 29, 2019
    Publication date: January 9, 2020
    Inventors: Yun-Long Li, Jincong Zhuo, Ding-Quan Qian, Song Mei, Ganfeng Cao, Yongchun Pan, Qun Li, Zhongjiang Jia
  • HETEROCYCLIC COMPOUNDS USEFUL AS PIM KINASE INHIBITORS
    Publication number: 20200002309
    Abstract: The present application is concerned with heterocyclic compounds that inhibit the activity of Pim kinases and are useful in the treatment of diseases related to the activity of Pim kinases including, e.g., cancers and other diseases.
    Type: Application
    Filed: September 9, 2019
    Publication date: January 2, 2020
    Inventors: Oleg Vechorkin, Yun-Long Li, Alexander Sokolsky, Anlai Wang, Wenyu Zhu, Jincong Zhuo
  • Thiazolecarboxamides and pyridinecarboxamide compounds useful as PIM kinase inhibitors
    Patent number: 10517858
    Abstract: The present disclosure describes thiazole and pyridine carboxamide derivatives, their compositions and methods of use. The compounds inhibit the activity of the Pim kinases and are useful in the treatment of diseases related to the activity of Pim kinases including, e.g., cancer and other diseases.
    Type: Grant
    Filed: March 11, 2019
    Date of Patent: December 31, 2019
    Assignees: Incyte Holdings Corporation, Incyte Corporation
    Inventors: Chu-Biao Xue, Yun-Long Li, Hao Feng, Ke Zhang
  • Pyrrolopyrimidine derivatives as TAM inhibitors
    Patent number: 10519163
    Abstract: This application relates to compounds of Formula I: or pharmaceutically acceptable salts thereof, which are inhibitors of TAM kinases which are useful for the treatment of disorders such as cancer.
    Type: Grant
    Filed: July 11, 2018
    Date of Patent: December 31, 2019
    Assignee: Incyte Corporation
    Inventors: Yun-Long Li, David M. Burns, Hao Feng, Joseph Glenn, Chunhong He, Song Mei, Jun Pan, Xiaozhao Wang, Yingda Ye
  • Bicyclic heteroarylaminoalkyl phenyl derivatives as PI3K inhibitors
    Patent number: 10479803
    Abstract: This application relates to derivatives of Formula I: and pharmaceutically acceptable salts thereof, which are inhibitors of PI3K, and compositions and methods of treatment related thereto.
    Type: Grant
    Filed: August 24, 2018
    Date of Patent: November 19, 2019
    Assignee: Incyte Corporation
    Inventors: Yun-Long Li, Andrew P. Combs
  • PHARMACEUTICAL COMPOSITIONS OF HYDROPHOBIC CAMPTOTHECIN DERIVATIVES
    Publication number: 20190321356
    Abstract: Provide is a method of using a topoisomerase I inhibitor in treatment of cancer to reduce bone marrow suppression. The method includes administering to a subject in need thereof an effective amount of a pharmaceutical composition. The composition has at least one hydrophobic topoisomerase I inhibitor or a pharmaceutically acceptable salt thereof, and at least one polyethylene glycol (PEG) conjugated phospholipid, wherein the molar ratio of said PEG conjugated phospholipid to said hydrophobic topoisomerase I inhibitor or said pharmaceutically acceptable salt of said hydrophobic topoisomerase I inhibitor is about 0.45:1 to about 1.05:1.
    Type: Application
    Filed: July 3, 2019
    Publication date: October 24, 2019
    Inventors: Pei KAN, ChiaHung HUNG, Keelung HONG, Yun-Long TSENG, Yung-Hsu CHAN
  • Heterocyclic compounds useful as Pim kinase inhibitors
    Patent number: 10450296
    Abstract: The present application is concerned with heterocyclic compounds that inhibit the activity of Pim kinases and are useful in the treatment of diseases related to the activity of Pim kinases including, e.g., cancers and other diseases.
    Type: Grant
    Filed: January 25, 2018
    Date of Patent: October 22, 2019
    Assignee: Incyte Corporation
    Inventors: Oleg Vechorkin, Yun-Long Li, Alexander Sokolsky, Anlai Wang, Wenyu Zhu, Jincong Zhuo
  • Pyrrolotriazine compounds as TAM inhibitors
    Patent number: 10442810
    Abstract: This application relates to compounds of Formula I: or pharmaceutically acceptable salts thereof, which are inhibitors of TAM kinases which are useful for the treatment of disorders such as cancer.
    Type: Grant
    Filed: May 4, 2018
    Date of Patent: October 15, 2019
    Assignee: Incyte Corporation
    Inventors: Yun-Long Li, Xiaozhao Wang, Chunhong He
  • Bipyrazole derivatives as JAK inhibitors
    Patent number: 10435392
    Abstract: The present invention provides compounds of Formula I: or pharmaceutically acceptable salts thereof, as well as their compositions and methods of use, that inhibit the activity of Janus kinase (JAK) and are useful in the treatment of diseases related to the activity of JAK including, for example, inflammatory disorders, autoimmune disorders, cancer, and other diseases.
    Type: Grant
    Filed: February 15, 2018
    Date of Patent: October 8, 2019
    Assignee: Incyte Corporation
    Inventors: Yun-Long Li, Jincong Zhuo, Ding-Quan Qian, Song Mei
  • Motor component, application device and sensor integrated circuit
    Patent number: 10439529
    Abstract: A sensor integrated circuit includes a rectifier, a power supply module, an output control circuit and a detecting circuit. The rectifier is configured to convert an external power supply into a first direct current power supply. The power supply module includes a voltage regulator configured to generate a second direct current power supply different from the first direct current power supply. The detecting circuit is powered by the second direct current power supply and configured to detect an inputted signal and correspondingly generate a control signal. The output control circuit is configured to control, in response to at least the control signal, the sensor integrated circuit to operate in at least one of a first state in which a current flows out from an output port and a second state in which a current flows in from the output port.
    Type: Grant
    Filed: August 8, 2016
    Date of Patent: October 8, 2019
    Assignee: JOHNSON ELECTRIC INTERNATIONAL AG
    Inventors: Chi Ping Sun, Fei Xin, Ken Wong, Shing Hin Yeung, Hui Min Guo, Shu Zuo Lou, Xiao Ming Chen, Guang Jie Cai, Chun Fai Wong, Shu Juan Huang, Yun Long Jiang, Yue Li, Bao Ting Liu, En Hui Wang, Xiu Wen Yang, Li Sheng Liu, Yan Yun Cui