Abstract: The present application provides methods of treating PI3K? related disorders using compounds of Formula I: or pharmaceutically acceptable salts thereof.

Abstract: A food processing apparatus is provided that includes: a housing structure, a food container structure which is disposed in the housing structure, and an image capturing module, which is located on the food container structure and includes a shell, an image capturing assembly and an air curtain assembly. The shell includes an optical channel which includes a lower opening end, an upper opening end and a wall surface disposed between the lower opening end and the upper opening end. The lower opening end faces the food container structure, the image capturing assembly is disposed at the upper opening end, and the air curtain assembly is disposed on the wall surface. In this way, the air curtain assembly can blow away or block the oil fumes after the food is heated, so that the image capturing module can observe the food processing clearly without being affected by the oil fumes.

Abstract: The present invention relates to pharmaceutical compositions comprising at least one liposome, at least one polyvalent counterion donor or a pharmaceutically acceptable salt thereof, at least one monovalent counterion donor or a pharmaceutically acceptable salt thereof, and an amphipathic therapeutic agent or a derivative or pharmaceutically acceptable salt thereof. The present invention also relates to methods of inhibiting cancer cell growth while reducing toxicity, comprising administering the pharmaceutical composition described herein.

Abstract: Embodiments of the disclosure provide an information processing method, an information processing apparatus, and a storage medium. The method includes: obtaining source data; encoding sub-data in the source data based on a target word feature vector to obtain hidden feature vectors corresponding to the sub-data, the target word feature vector representing a sentiment feature standard; obtaining a word feature vector corresponding to the source data based on the hidden feature vectors corresponding to the sub-data; and inputting the word feature vector into a preset sentiment classification network to obtain a result of sentiment polarity prediction of the source data. According to the embodiments of the disclosure, the accuracy of sentiment polarity prediction may be improved.

Abstract: This application relates to compounds of Formula I: or pharmaceutically acceptable salts thereof, which are inhibitors of TAM kinases which are useful for the treatment of disorders such as cancer.

Abstract: This application relates to derivatives of Formula I: and pharmaceutically acceptable salts thereof, which are inhibitors of PI3K, and compositions and methods of treatment related thereto.

Abstract: The present invention provides pyrimidinones that modulate the activity of phosphoinositide 3-kinases (PI3Ks) and are useful in the treatment of diseases related to the activity of PI3Ks including, for example, inflammatory disorders, immune-based disorders, cancer, and other diseases.

Abstract: The present invention provides compounds of Formula I: or pharmaceutically acceptable salts thereof, as well as their compositions and methods of use, that inhibit the activity of Janus kinase (JAK) and are useful in the treatment of diseases related to the activity of JAK including, for example, inflammatory disorders, autoimmune disorders, cancer, and other diseases.

Abstract: The present application is concerned with heterocyclic compounds that inhibit the activity of Pim kinases and are useful in the treatment of diseases related to the activity of Pim kinases including, e.g., cancers and other diseases.

Abstract: Provided is an artificial intelligence (AI) computing device applied to an industrial automation system. The AI computing device is connected to a field bus via a field bus interface and is communicated with a controller. The AI computing device processes data sent by the controller by using a built-in AI computing architecture, analyzes the data, and sends the analysis result to the controller. Also provided are a corresponding method and apparatus, an engineer station, and an industrial automation system.

Abstract: A bean roasting apparatus with a stirring barrel body, a receiving structure and an image capturing assembly is provided. The stirring barrel body has an opening. The receiving structure has a bean-through opening and an observation opening. The image capturing assembly has at least one image capturing device and a reflective surface which is disposed in the capturing scope of the at least one image capturing device and is tilted facing the at least one image capturing device and the observation opening. Therefore, the at least one image capturing device can capture an image inside the receiving structure through the reflective surface and the observation opening. Another bean roasting apparatus with an image capturing assembly is provided, wherein at least one image capturing device of the image capturing assembly can capture an image inside the receiving structure through the observation opening directly.

Abstract: The present invention provides methods of treating arthritis. A sustained release composition comprising liposomes and one or more therapeutic agent or a pharmaceutically acceptable salt thereof is administered to a subject in need thereof. The liposomes may be in an aqueous suspension. The sustained release composition can be administered intraarticularly.

Abstract: This application relates to compounds of Formula I: or pharmaceutically acceptable salts thereof, which are inhibitors of TAM kinases which are useful for the treatment of disorders such as cancer.

Abstract: The present invention provides compounds of Formula I: or pharmaceutically acceptable salts thereof, as well as their compositions and methods of use, that inhibit the activity of Janus kinase (JAK) and are useful in the treatment of diseases related to the activity of JAK including, for example, inflammatory disorders, autoimmune disorders, cancer, and other diseases.

Abstract: Provided is an anesthetic composition for locally administering a local anesthetic agent to a subject in need thereof. The anesthetic composition has a lipid based complex prepared by hydrating a lipid cake containing a local anesthetic agent and a lipid mixture with an aqueous buffer solution at a pH higher than 5.5. Also provided is a method to prepare an anesthetic composition using a simpler and more robust for large-scale manufacture and for providing a high molar ratio of local anesthetic agent to phospholipid content as compared to the prior art. This anesthetic composition has a prolonged duration of efficacy adapted to drug delivery.

Abstract: Provide is a method of using a topoisomerase I inhibitor in treatment of cancer to reduce bone marrow suppression. The method includes administering to a subject in need thereof an effective amount of a pharmaceutical composition. The composition has at least one hydrophobic topoisomerase I inhibitor or a pharmaceutically acceptable salt thereof, and at least one polyethylene glycol (PEG) conjugated phospholipid, wherein the molar ratio of said PEG conjugated phospholipid to said hydrophobic topoisomerase I inhibitor or said pharmaceutically acceptable salt of said hydrophobic topoisomerase I inhibitor is about 0.45:1 to about 1.05:1.

Abstract: The present invention provides methods of treating arthritis. A sustained release composition comprising liposomes and one or more therapeutic agent or a pharmaceutically acceptable salt thereof is administered to a subject in need thereof. The liposomes may be in an aqueous suspension. The sustained release composition can be administered intraarticularly.

Abstract: The present application relates to a system and method for sharing data on a medical cloud platform based on third-party business. The system includes: a terminal device and a cloud platform. The cloud platform receives a massive quantity of vital-sign data that are sent by the terminal device, analyzes and processes the massive quantity of vital-sign data by using the deep-learning framework of distributed parallel computation, screens abnormal data, and sends an abnormal-event warning to the user, to prompt the medical care personnel to quickly intervene.

Abstract: Provided herein are benzimidazole derivatives, for example, of Formula (I), and pharmaceutical compositions thereof. Also provided herein are methods of their use for treating, preventing, or ameliorating one or more symptoms of a proliferative disease.

Abstract: A submersible power generating system for generating electricity from total potential energy of still water has a closed endless rotation cascade cage apparatus, a compressed air generating apparatus, a compressed air storage apparatus, a gas injection apparatus, a gas retrieving apparatus, a building, an initiation power supply apparatus, a power generating apparatus, an intelligent control apparatus, a safety apparatus, a water treatment apparatus and a maintenance facility. The submersible power generating system makes full use of natural properties of water and air, performs continuous energy conversion, and achieves energy balance in three stages, so as to directly converse total potential energy of still water into electric energy, thereby achieving stable power production and obtaining inexhaustible and clean electric energy.