Patents by Inventor Yunlong Zhang

Yunlong Zhang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20240229373
    Abstract: A slope trimming attachment includes a base, a first cutting device, a leveling mechanism and a turning mechanism. The first cutting device and the leveling mechanism are respectively arranged on the turning mechanism. The turning mechanism is rotatably arranged on the base and is configured to be able to adjust an angle of the cutting surface of the first cutting device relative to the slope surface and an angle of the leveling surface of the leveling mechanism relative to the slope surface through rotation. A working machine with the disclosed slope trimming attachment is not only convenient to operate, but also realizes the simultaneous execution of cutting, leveling and compacting operations on the slope surface, improves the construction efficiency of the slope surface trimming, and thereby ensuring the construction quality.
    Type: Application
    Filed: April 29, 2022
    Publication date: July 11, 2024
    Inventors: Hao Chen, Yunlong Zhang, Youfa Cheng
  • Publication number: 20240197922
    Abstract: Methods of manufacturing a biological therapy are described. The methods can comprise detecting a level of a molecular attribute of the biological therapy in a formulation, determining a rate of change of the molecular attribute under the storage conditions, and estimating a level of molecular attribute exposure received by the subjects at the time of said administration. Production lots of the biological therapy comprising the molecular attribute can be manufactured comprising the molecular attribute at or below a specified specification for permissible levels of the molecular attribute based on the estimated level of molecule attribute exposure. Methods of developing a manufacturing process for a biological therapy are described. Methods of assessing the clinical impact of a molecular attribute of a biological therapy are described.
    Type: Application
    Filed: June 13, 2023
    Publication date: June 20, 2024
    Applicant: AMGEN INC.
    Inventors: Nathan JOH, Marisa JOUBERT, Gerd Richard KLEEMAN, Linda Owers NARHI, Noel J. RIEDER, Joshua TOKUDA, Zhongqi ZHANG, Yunlong ZHANG
  • Publication number: 20240051423
    Abstract: A charging pile type recognition method includes: obtaining a charging parameter of an electric vehicle within a preset time period; determining a proportion of a preset power charging capacity of a charging pile within the preset time period according to the charging parameter, wherein the proportion of the preset power charging capacity is equal to a ratio of a first amount of electricity charged into the electric vehicle by the charging pile at a preset power within the preset time period to a total amount of electricity charged into the electric vehicle by the charging pile within the preset time period; and determining a type of the charging pile according to the proportion of the preset power charging capacity.
    Type: Application
    Filed: September 28, 2023
    Publication date: February 15, 2024
    Inventors: Yunlong ZHANG, Haowen LI, Honglin YANG, Yiwen HUANG, Anjin PAN, Jibing JIANG
  • Publication number: 20240043402
    Abstract: The present disclosure is directed to tetrahydroquinazoline derivatives of Formula (I) and their use for selectively killing HIV infected GAG-POL expressing cells without concomitant cytotoxicity to HIV naive cells, and for the treatment or prophylaxis of infection by HIV, or for the treatment, prophylaxis or delay in the onset or progression of AIDS or AIDS Related Complex (ARC).
    Type: Application
    Filed: December 6, 2021
    Publication date: February 8, 2024
    Applicant: Merck Sharp & Dohme LLC
    Inventors: Antonella Converso, David N. Hunter, Abdellatif El Marrouni, Anthony J. Roecker, Anthony W. Shaw, William D. Shipe, Cheng Wang, Deping Wang, Yunlong Zhang
  • Publication number: 20230357204
    Abstract: The present disclosure is directed to tetrahydroquinazoline derivatives of Formula I and their use for selectively killing HIV infected GAG-POL expressing cells without concomitant cytotoxicity to HIV naïve cells, and for the treatment or prophylaxis of infection by HIV, or for the treatment, prophylaxis or delay in the onset or progression of AIDS or AIDS Related Complex (ARC).
    Type: Application
    Filed: August 25, 2021
    Publication date: November 9, 2023
    Applicant: Merck Sharp & Dohme LLC
    Inventors: Antonella Converso, Abdellatif El Marrouni, Anthony W. Shaw, David N. Hunter, Ashley Forster, Cheng Wang, Yunlong Zhang
  • Patent number: 11648250
    Abstract: The present disclosure is directed to tetrahydroquinazoline derivatives of Formula I and their use for selectively killing HIV infected GAG-POL expressing cells without concomitant cytotoxicity to HIV naïve cells, and for the treatment or prophylaxis of infection by HIV, or for the treatment, prophylaxis or delay in the onset or progression of AIDS or AIDS Related Complex (ARC).
    Type: Grant
    Filed: August 25, 2021
    Date of Patent: May 16, 2023
    Assignee: Merck Sharp & Dohme LLC
    Inventors: Antonella Converso, Abdellatif El Marrouni, Anthony W. Shaw, David N. Hunter, Ashley Forster, Cheng Wang, Yunlong Zhang
  • Publication number: 20230124955
    Abstract: Described herein are compounds and compositions characterized, in certain embodiments, by conjugation of various groups, such as lipophilic groups, to an amino or amide group of an amino acid, a linear or cyclic peptide, a linear or cyclic polypeptide, or structural isomer thereof, to provide compounds of the present invention, collectively referred to herein as “APPLs”. Such APPLs are deemed useful for a variety of applications, such as, for example, improved nucleotide delivery. Exemplary APPLs include, but are not limited to, compounds of Formula (I), (II), (III), (IV), (V), and (VI), and salts thereof, as described herein: wherein m, n, p, R?, R1, R2, R3, R4, R5, R8, Z, W, Y, and Z are as defined herein.
    Type: Application
    Filed: August 23, 2022
    Publication date: April 20, 2023
    Applicant: Massachusetts Institute of Technology
    Inventors: Yizhou Dong, Kevin Thomas Love, Robert S. Langer, Daniel Griffith Anderson, Delai Chen, Yi Chen, Arturo Jose Vegas, Akinleye C. Alabi, Yunlong Zhang
  • Patent number: 11590991
    Abstract: A bogie and a rail vehicle, wherein the bogie includes: a framework, a wheel pair connected to the framework, a braking hanger fixed to the framework, a hanger slider used for fixedly connecting to a vehicle wheel braking clamp, and a transmission member; the hanger slider is connected to the braking hanger, and the transmission member is connected to the hanger slider; a first end of the transmission member extends to a side surface of a vehicle wheel in the wheel pair, and the transmission member is used to drive the hanger slider to move along the lateral direction with respect to the braking hanger when the first end is subjected to a thrust applied in the lateral direction by the vehicle wheel, so that the vehicle wheel braking clamp moves to a position corresponding to the vehicle wheel.
    Type: Grant
    Filed: August 20, 2018
    Date of Patent: February 28, 2023
    Assignee: CRRC TANGSHAN CO., LTD.
    Inventors: Lixin Zhang, Hongjiang Xu, Hongwei Jing, Yunlong Zhang, Chuan Ma, Guangsheng Zheng, Chao Li
  • Patent number: 11458158
    Abstract: Described herein are compounds and compositions characterized, in certain embodiments, by conjugation of various groups, such as lipophilic groups, to an amino or amide group of an amino acid, a linear or cyclic peptide, a linear or cyclic polypeptide, or structural isomer thereof, to provide compounds of the present invention, collectively referred to herein as “APPLs”. Such APPLs are deemed useful for a variety of applications, such as, for example, improved nucleotide delivery. Exemplary APPLs include, but are not limited to, compounds of Formula (I), (II), (III), (IV), (V), and (VI), and salts thereof, as described herein: wherein m, n, p, R?, R1, R2, R3, R4, R5, R8, Z, W, Y, and Z are as defined herein.
    Type: Grant
    Filed: May 5, 2020
    Date of Patent: October 4, 2022
    Assignee: Massachusetts Institute of Technology
    Inventors: Yizhou Dong, Kevin Thomas Love, Robert S. Langer, Daniel Griffith Anderson, Delai Chen, Yi Chen, Arturo Jose Vegas, Akinleye C. Alabi, Yunlong Zhang
  • Publication number: 20220289700
    Abstract: Epoxide functionalized polyaromatic feedstocks and processes for their preparation are described. The processes involve functionalizing polyaromatic hydrocarbon molecules and/or polyheterocyclic molecules present in petroleum or petrochemical streams with epoxide. The epoxide functionalized poly aromatic feedstock can be further treated so as to effect oligomerization or polymerization. The oligomers or polymers may be thermoplastic or thermoset materials and may find use in, for example, infrastructure applications, composites, fillers, fire retardants and 3-D printing materials.
    Type: Application
    Filed: August 10, 2020
    Publication date: September 15, 2022
    Inventors: Yunlong Zhang, Jordan N. Metz
  • Publication number: 20220282091
    Abstract: Processes for chemically treating polyaromatic feedstock to form aromatic-containing oligomers or polymers are provided. The processes are characterized by treatment of a plurality of different polyaromatic hydrocarbon molecules and/or polyheterocyclic molecules present in polyaromatic feedstock with a first reagent so as to functionalize the molecules. Further treatment in a second step affords oligomeric or polymeric products which may be crosslinked. The products may be thermoplastic or thermoset materials and may find use in, for example, infrastructure applications, composites, fillers, fire retardants and 3-D printing materials.
    Type: Application
    Filed: August 10, 2020
    Publication date: September 8, 2022
    Inventors: Yunlong Zhang, Jordan N. Metz, Huaxing Zhou, August W. Bosse, Suzzy C. Ho, Timothy D. Shaffer, Ozcan Altintas
  • Publication number: 20220062284
    Abstract: The present disclosure is directed to tetrahydroquinazoline derivatives of Formula I and their use for selectively killing HIV infected GAG-POL expressing cells without concomitant cytotoxicity to HIV naïve cells, and for the treatment or prophylaxis of infection by HIV, or for the treatment, prophylaxis or delay in the onset or progression of AIDS or AIDS Related Complex (ARC).
    Type: Application
    Filed: August 25, 2021
    Publication date: March 3, 2022
    Applicant: Merck Sharp & Dohme Corp.
    Inventors: Antonella Converso, Abdellatif El Marrouni, Anthony W. Shaw, David N. Hunter, Ashley Forster, Cheng Wang, Yunlong Zhang
  • Publication number: 20210237782
    Abstract: A bogie and a rail vehicle, wherein the bogie includes: a framework, a wheel pair connected to the framework, a braking hanger fixed to the framework, a hanger slider used for fixedly connecting to a vehicle wheel braking clamp, and a transmission member; the hanger slider is connected to the braking hanger, and the transmission member is connected to the hanger slider; a first end of the transmission member extends to a side surface of a vehicle wheel in the wheel pair, and the transmission member is used to drive the hanger slider to move along the lateral direction with respect to the braking hanger when the first end is subjected to a thrust applied in the lateral direction by the vehicle wheel, so that the vehicle wheel braking clamp moves to a position corresponding to the vehicle wheel.
    Type: Application
    Filed: August 20, 2018
    Publication date: August 5, 2021
    Applicant: CRRC TANGSHAN CO., LTD.
    Inventors: Lixin ZHANG, Hongjiang XU, Hongwei JING, Yunlong ZHANG, Chuan MA, Guangsheng ZHENG, Chao LI
  • Patent number: 10858342
    Abstract: The present invention relates to compounds of formula I: and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, R5 and n are as defined herein. The invention also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.
    Type: Grant
    Filed: June 21, 2017
    Date of Patent: December 8, 2020
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Michael Balestra, Jennifer Burke, Zhidong Chen, Derek Cogan, John Lord, Daniel Richard Marshall, Bryan P. McKibben, Kenneth M. Meyers, Yunlong Zhang
  • Patent number: D968347
    Type: Grant
    Filed: December 25, 2020
    Date of Patent: November 1, 2022
    Assignee: BEIJING XIAOMI MOBILE SOFTWARE CO., LTD.
    Inventors: Luxi Wang, Yunlong Zhang
  • Patent number: D974340
    Type: Grant
    Filed: December 23, 2020
    Date of Patent: January 3, 2023
    Assignee: Beijing Xiaomi Mobile Software Co., Ltd.
    Inventor: Yunlong Zhang
  • Patent number: D979525
    Type: Grant
    Filed: June 4, 2021
    Date of Patent: February 28, 2023
    Assignee: BEIJING XIAOMI MOBILE SOFTWARE CO., LTD.
    Inventors: Yunlong Zhang, Rui Yin
  • Patent number: D982538
    Type: Grant
    Filed: December 23, 2020
    Date of Patent: April 4, 2023
    Assignee: Beijing Xiaomi Mobile Software Co., Ltd.
    Inventor: Yunlong Zhang
  • Patent number: D984974
    Type: Grant
    Filed: September 14, 2021
    Date of Patent: May 2, 2023
    Assignee: BEIJING XIAOMI MOBILE SOFTWARE CO., LTD.
    Inventor: Yunlong Zhang
  • Patent number: D1031680
    Type: Grant
    Filed: October 13, 2021
    Date of Patent: June 18, 2024
    Assignee: BEIJING XIAOMI MOBILE SOFTWARE CO., LTD.
    Inventor: Yunlong Zhang