Patents by Inventor Yunlong Zhang
Yunlong Zhang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 9079880Abstract: The present invention relates to compounds of formula (I): and pharmaceutically acceptable salts thereof, wherein R1 and X are as defined herein. The invention also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.Type: GrantFiled: June 29, 2011Date of Patent: July 14, 2015Assignee: Boehringer Ingelheim International GmbHInventors: John David Ginn, Daniel Richard Marshall, Robert Sibley, Ronald John Sorcek, Erick Richard Roush Young, Yunlong Zhang
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Patent number: 9073926Abstract: The present invention relates to compounds of Formula (I) and pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R4, R5 and n are as defined herein. The invention also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.Type: GrantFiled: December 1, 2010Date of Patent: July 7, 2015Assignee: Boehringer Ingelheim International GmbHInventors: Stephen James Boyer, Jennifer Burke, Xin Guo, Thomas Martin Kirrane, Jr., Roger John Snow, Yunlong Zhang
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Patent number: 9037222Abstract: This document discusses, among other things, a system comprising a sensor signal processor configured to receive a plurality of electrical sensor signals produced by a plurality of sensors and at least one sensor signal produced by an implantable sensor, a memory that includes information indicating a co-morbidity of a subject, a sensor signal selection circuit that selects a sensor signal to monitor from among the plurality of sensor signals, according to an indicated co-morbidity, a threshold adjustment circuit that adjusts a detection threshold of the selected sensor signal according to the indicated co-morbidity, and a decision circuit that applies the adjusted detection threshold to the selected sensor signal to determine whether an event associated with worsening heart failure (HF) occurred in the subject and outputs an indication of whether the event associated with worsening HF occurred to a user or process.Type: GrantFiled: December 26, 2013Date of Patent: May 19, 2015Assignee: Cardiac Pacemakers, Inc.Inventors: Haresh G. Sachanandani, Yunlong Zhang
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Patent number: 9031669Abstract: Various implantable medical device embodiments stimulate an autonomic neural target from within a pulmonary artery, and comprise at least one electrode, a power supply, a neural stimulator connected to the power supply, and an anchor structure. The neural stimulator is configured to generate a neural stimulation signal for delivery to the neural stimulation target through the at least one electrode. The anchor structure is configured to chronically and securely implant the neural stimulator, the power supply and the at least one electrode within the pulmonary artery. The anchor structure, the neural stimulator, the power supply and the at least one electrode are configured to be implanted through a pulmonary valve into the pulmonary artery. In various embodiments, the neural stimulator is configured to be operational to implement a neural stimulation protocol when chronically implanted within the pulmonary artery without a wired connection through the pulmonary valve.Type: GrantFiled: August 12, 2013Date of Patent: May 12, 2015Assignee: Cardiac Pacemakers, Inc.Inventors: Yunlong Zhang, Haresh G. Sachanandani, Dan Li, Bin Mi
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Patent number: 9026201Abstract: Various method embodiments of the present invention concern sensing patient-internal pressure measurements indicative of physiological exertion, identifying one or more steady state periods of physiological exertion based on the patient-internal pressure measurements, sensing extra-cardiac response data and cardiac response data corresponding to the one or more physiological exertion steady state periods, respectively comparing the extra-cardiac response data and the cardiac response data to extra-cardiac response information and cardiac response information associated with equivalent levels of physiological exertion intensity of the one or more steady state periods, and determining the likelihood that myocardial ischemia occurred during the one or more steady state periods based on the comparison of the extra-cardiac response data to the extra-cardiac response information and the cardiac response data to the cardiac response information.Type: GrantFiled: November 27, 2012Date of Patent: May 5, 2015Assignee: Cardiac Pacemakers, Inc.Inventors: Yi Zhang, Kenneth C. Beck, Aaron Lewicke, Yunlong Zhang
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Publication number: 20140336521Abstract: A system to measure intracardiac impedance includes implantable electrodes and a medical device. The electrodes sense electrical signals of a heart of a subject. The medical device includes a cardiac signal sensing circuit coupled to the implantable electrodes, an impedance measurement circuit coupled to the same or different implantable electrodes, and a controller circuit coupled to the cardiac signal sensing circuit and the impedance measurement circuit. The cardiac signal sensing circuit provides a sensed cardiac signal. The impedance measurement circuit senses intracardiac impedance between the electrodes to obtain an intracardiac impedance signal. The controller circuit determines cardiac cycles of the subject using the sensed cardiac signal, and detects tachyarrhythmia using cardiac-cycle to cardiac-cycle changes in a plurality of intracardiac impedance parameters obtained from the intracardiac impedance signal.Type: ApplicationFiled: May 7, 2013Publication date: November 13, 2014Applicant: Cardiac Pacemakers, Inc.Inventors: Yunlong Zhang, James O. Gilkerson, Yongxing Zhang, Loell Boyce Moon
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Patent number: 8851828Abstract: The present invention discloses a rotor of wind energy conversion system (WECS) with the Venturi-tube effect. All the blades mounted on the blade-mounting seat envelop together to form a revolving-body cage turbine, which can be divided from structure into a head portion at the windward end, a tail portion at the wind exhaust end, and an airstream compression portion between the head portion and the tail portion and constituted by the enveloping blades. The revolution diameter of the airstream compression portion is gradually substantially increased from the head portion to the tail portion. The cage turbine forms a dynamic Venturi tube during the revolving process, with which the blade revolves to constitute its outline tube wall with the air permeability. The airstream passes through a window between the blades, and the incoming wind does work towards the blade during the process of permeating from the external space to the internal space of this outline tube wall, thus realizing the energy transfer.Type: GrantFiled: September 22, 2009Date of Patent: October 7, 2014Assignees: Shanghai Forevoo New Energy Systems, Co. Ltd., Shanghai Powerfooo Energy System Co., Ltd.Inventor: Yunlong Zhang
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Publication number: 20140232672Abstract: A touch-based triggering method is provided for a mobile terminal. The method includes receiving a plurality of touch trajectories and, based on application programs or application program functions to be configured, establishing a mapping index table for storing mapping relationships between the received touch trajectories and the application programs or application program functions. The method also includes storing the mapping index table on the mobile terminal. Further, the method includes detecting and responding to a touch event, obtaining a touch trajectory corresponding to the touch event, comparing the obtained touch trajectory with the touch trajectories stored in the mapping index table for similarity matching and, when the obtained touch trajectory matches a stored touch trajectory in the mapping index table, triggering the application program or application program function corresponding to the stored touch trajectory.Type: ApplicationFiled: April 10, 2014Publication date: August 21, 2014Applicant: TENCENT TECHNOLOGY (SHENZHEN) COMPANY LIMITEDInventor: YUNLONG ZHANG
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Patent number: 8777557Abstract: The present invention provides a controllable compound rotor system for the WECS, with a pilot rotor working under low wind speed conditions and a main rotor working under high speed conditions. By proper switching of the clutch, the WECS can not only achieve a greater starting torque under low wind speed conditions, as well as to capture and utilize the low wind-speed wind energy after being started, but also give full play to the advantage of the main rotor having the excellent wind capturing efficiency under high wind speed and high turning speed conditions. Thus the WECS can capture and utilize wind energy under both low and high wind speed conditions, which greatly expands the speed and zone range wherein the WECS can be applied, facilitating wide application of the WECS.Type: GrantFiled: September 3, 2009Date of Patent: July 15, 2014Assignees: Shanghai Forevoo Windpower Technology Co., Ltd., Shanghai Powerfood Energy System Co., Ltd.Inventors: Yunlong Zhang, Hongying Zhang
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Patent number: 8781604Abstract: A lead includes a lead body and an electrode disposed proximate a distal end of the lead body. A retaining member is disposed proximate the distal end of the lead and adapted to retain the electrode proximate an interatrial septum when the retaining member is located on a left atrial side of the interatrial septum.Type: GrantFiled: April 1, 2009Date of Patent: July 15, 2014Assignee: Cardiac Pacemakers, Inc.Inventors: Yongxing Zhang, Yunlong Zhang
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Patent number: 8770574Abstract: A paper feeding mechanism includes a vacuum absorption variable-speed paper feeding mechanism and a vacuum absorption constant-speed paper feeding mechanism, two edge pressing wheels are installed on a edge pressing paper feeding shaft arranged above a constant-speed paper feeding wheel in the middle, the gaps between the edge pressing wheels and the constant-speed paper feeding wheel in the middle are smaller than the thickness of a paper board, and the distance between the two edge pressing wheels is adjusted by moving on the edge pressing paper feeding wheel shaft.Type: GrantFiled: May 4, 2011Date of Patent: July 8, 2014Assignee: Qingdao Meiguang Machinery Co., Ltd.Inventors: Yanyou Zhu, Yunlong Zhang, Zonghua Xu
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Patent number: 8768444Abstract: An implantable medical device senses a plurality of electrograms from substantially different atrial locations, detects regional depolarizations from the electrograms, and analyzes timing relationships among the regional depolarizations. The timing relationships provide a basis for effective therapy control and/or prognosis of certain cardiac disorders. In one embodiment, an atrial activation sequence is mapped to show the order of occurrences of the regional depolarizations during an atrial depolarization for classifying a detected tachyarrhythmia by its origin. In another embodiment, conduction time between two atrial locations is measured for monitoring the development of an abnormal atrial conditions and/or the effect of a therapy.Type: GrantFiled: November 1, 2011Date of Patent: July 1, 2014Assignee: Cardiac Pacemakers, Inc.Inventors: Yunlong Zhang, Julie A. Thompson, James O. Gilkerson, Yongxing Zhang
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Publication number: 20140161830Abstract: Provided herein are lipidoids that may be prepared from the conjugate addition of alkylamines to acrylates. In some embodiments, provided lipidoids are biodegradable and may be used in a variety of drug delivery systems. Given the amino moiety of the lipidoids, they are well-suited for the delivery of polynucleotides, in addition to other agents. Nanoparticles containing the inventive lipidoids and polynucleotides have been prepared and have been shown to be effective in delivering siRNA.Type: ApplicationFiled: November 25, 2013Publication date: June 12, 2014Applicant: Massachusetts Institute of TechnologyInventors: Daniel Griffith Anderson, Kathryn Ann Whitehead, Joseph R. Dorkin, Arturo Jose Vegas, Yunlong Zhang
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Patent number: 8712521Abstract: This document discusses, among other things, systems, devices, and methods for measuring cardiac impedances and producing one or more resynchronization index parameters each indicative of a cardiac synchrony or asynchrony using the measured cardiac impedances. In one example, the one or more resynchronization index parameters are used to adjust one or more pacing parameters of a cardiac resynchronization therapy.Type: GrantFiled: June 29, 2011Date of Patent: April 29, 2014Assignee: Cardiac Pacemakers, Inc.Inventor: Yunlong Zhang
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Publication number: 20140107503Abstract: This document discusses, among other things, a system comprising a sensor signal processor configured to receive a plurality of electrical sensor signals produced by a plurality of sensors and at least one sensor signal produced by an implantable sensor, a memory that includes information indicating a co-morbidity of a subject, a sensor signal selection circuit that selects a sensor signal to monitor from among the plurality of sensor signals, according to an indicated co-morbidity, a threshold adjustment circuit that adjusts a detection threshold of the selected sensor signal according to the indicated co-morbidity, and a decision circuit that applies the adjusted detection threshold to the selected sensor signal to determine whether an event associated with worsening heart failure (HF) occurred in the subject and outputs an indication of whether the event associated with worsening HF occurred to a user or process.Type: ApplicationFiled: December 26, 2013Publication date: April 17, 2014Applicant: Cardiac Pacemakers, Inc.Inventors: Haresh G. Sachanandani, Yunlong Zhang
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Patent number: 8697911Abstract: The present invention relates to compounds of formula (I): and pharmaceutically acceptable salts thereof, wherein R1 and R2 are as defined herein. The invention also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.Type: GrantFiled: June 29, 2011Date of Patent: April 15, 2014Assignee: Boehringer Ingelheim International GmbHInventors: Brian Nicholas Cook, Jennifer A. Kowalski, Xiang Li, Daniel Richard Marshall, Sabine Schlyer, Robert Sibley, Lana Louise Smith-Keenan, Fariba Soleymanzadeh, Ronald John Sorcek, Erick Richard Roush Young, Yunlong Zhang
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Patent number: 8644916Abstract: This document discusses, among other things, a system comprising a sensor signal processor configured to receive a plurality of electrical sensor signals produced by a plurality of sensors and at least one sensor signal produced by an implantable sensor, a memory that includes information indicating a co-morbidity of a subject, a sensor signal selection circuit that selects a sensor signal to monitor from among the plurality of sensor signals, according to an indicated co-morbidity, a threshold adjustment circuit that adjusts a detection threshold of the selected sensor signal according to the indicated co-morbidity, and a decision circuit that applies the adjusted detection threshold to the selected sensor signal to determine whether an event associated with worsening heart failure (HF) occurred in the subject and outputs an indication of whether the event associated with worsening HF occurred to a user or process.Type: GrantFiled: March 22, 2013Date of Patent: February 4, 2014Assignee: Cardiac Pacemakers, Inc.Inventors: Haresh G. Sachanandani, Yunlong Zhang
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Publication number: 20140031339Abstract: The present invention relates to compounds of formula (I): or a pharmaceutically acceptable salt thereof, wherein A1, A2, L1 and B are as defined herein. The compounds of formula (I) are useful as inhibitors of leukotriene A4 hydrolase (LTA4H) and treating LTA4H related disorders. The present invention also relates to pharmaceutical compositions comprising the compounds of formula (I), methods of using these compounds in the treatment of various diseases and disorders, and processes for preparing these compounds.Type: ApplicationFiled: July 16, 2013Publication date: January 30, 2014Applicant: BOEHRINGER INGELHEIM INTERNATIONAL GMBHInventors: Asitha ABEYWARDANE, Steven Richard BRUNETTE, Michael Jason BURKE, Thomas Martin KIRRANE, JR., Chuk Chui MAN, Daniel Richard MARSHALL, Anil Kumar PADYANA, Hossein RAZAVI, Robert SIBLEY, Lana Louise SMITH KEENAN, Roger John SNOW, Ronald John SORCEK, Hidenori TAKAHASHI, Steven John TAYLOR, Michael Robert TURNER, Erick Richard Roush YOUNG, Qiang ZHANG, Yunlong ZHANG, Renee M. ZINDELL
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Publication number: 20130331919Abstract: Various implantable medical device embodiments stimulate an autonomic neural target from within a pulmonary artery, and comprise at least one electrode, a power supply, a neural stimulator connected to the power supply, and an anchor structure. The neural stimulator is configured to generate a neural stimulation signal for delivery to the neural stimulation target through the at least one electrode. The anchor structure is configured to chronically and securely implant the neural stimulator, the power supply and the at least one electrode within the pulmonary artery. The anchor structure, the neural stimulator, the power supply and the at least one electrode are configured to be implanted through a pulmonary valve into the pulmonary artery. In various embodiments, the neural stimulator is configured to be operational to implement a neural stimulation protocol when chronically implanted within the pulmonary artery without a wired connection through the pulmonary valve.Type: ApplicationFiled: August 12, 2013Publication date: December 12, 2013Applicant: Cardiac Pacemakers, Inc.Inventors: Yunlong Zhang, Haresh G. Sachanandani, Dan Li, Bin Mi
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Patent number: 8527064Abstract: Various implantable medical device embodiments stimulate an autonomic neural target from within a pulmonary artery, and comprise at least one electrode, a power supply, a neural stimulator connected to the power supply, and an anchor structure. The neural stimulator is configured to generate a neural stimulation signal for delivery to the neural stimulation target through the at least one electrode. The anchor structure is configured to chronically and securely implant the neural stimulator, the power supply and the at least one electrode within the pulmonary artery. The anchor structure, the neural stimulator, the power supply and the at least one electrode are configured to be implanted through a pulmonary valve into the pulmonary artery. In various embodiments, the neural stimulator is configured to be operational to implement a neural stimulation protocol when chronically implanted within the pulmonary artery without a wired connection through the pulmonary valve.Type: GrantFiled: December 3, 2008Date of Patent: September 3, 2013Assignee: Cardiac Pacemakers, Inc.Inventors: Yunlong Zhang, Haresh G. Sachanandani, Dan Li, Bin Mi