Abstract: Provided is a compound (Z) represented by the formula (1) or (2) below. In the formulas (1) and (2), Xs in each of the formulas (1) and (2) are each independently a carboxy group, a carboxylate group, or a monovalent group represented by the formula (3); at least one of Xs in each of the formulas (1) and (2) is a carboxy group or a carboxylate group; and at least one of Xs in each of the formulas (1) and (2) is a monovalent group represented by the formula (3) —C(O)—Y-(AO)n—R (3). In the formula (3), —Y— is —O—, —NH—, or —S—; A is a C2-C4 alkylene group; R is a hydrogen atom or a C1-C15 monovalent hydrocarbon group in which a hydrogen atom is optionally substituted with a C1-C10 alkoxy group; n is an integer of 4 to 1000; at least one of n As is an ethylene group; and when the formulas (1) and (2) each have multiple monovalent groups represented by the formula (3), each of —Y—, A, R, and n is the same or different among the monovalent groups.

Abstract: A gas sensor includes a sensor element, at least one powder compact, and at least one dense body. The sensor element includes an element body, a detection portion, at least one connector electrode, a porous layer, and a water intrusion reducing portion. The water intrusion reducing portion includes a plurality of dense layers that are arranged at intervals in the longitudinal direction and have a porosity of less than 10%, each of the plurality of dense layers being disposed such that a position thereof in the longitudinal direction overlaps an inner circumferential surface of any of the at least one dense body.

Abstract: A sensor element for detecting a specific gas concentration in a measurement-object gas, the sensor element includes; an elongate element body that includes a solid electrolyte layer and has a shape including at least one side surface extending in a longitudinal direction; a dense layer that is disposed on the side surface; and an intermediate layer disposed at least between the dense layer and the element body, wherein, when thermal expansion coefficients of the solid electrolyte layer, the dense layer, and the intermediate layer in a temperature range of from 20° C. to 1360° C. are denoted by thermal expansion coefficients Ea, Eb, and Ec, respectively, a ratio Ea/Eb is more than 1.0 and 5.0 or less, and Ea>Ec>Eb is satisfied.

Abstract: Provided are a biomarker identifying method including (1) to (4) and an application thereof. (1) An evaluation value for each of a plurality of biomarkers is derived based on annotation information imparted to each of biomarkers, and a measurement target biomarker is selected based on the evaluation value. (2) The evaluation data of the measurement target biomarker is acquired from the cell A and/or the culture system, before the start of culture of the cell A and/or during the culture. (3) The evaluation data of the discrimination marker of the B cell is acquired from the cell A and/or the culture system, at the final stage of the culture of the cell A and/or after the end of the culture. (4) At least one biomarker indicating characteristics of the cell A is identified from among the measurement target biomarkers, based on the data obtained from (2) and (3).

Abstract: An object of the present invention is to provide a method of producing a pluripotent stem cell capable of differentiating into a specific cell. According to the present invention, there is provided a method for producing a pluripotent stem cell capable of differentiating into a specific cell, the method including (i) a step of measuring, in a pluripotent stem cell as a sample, a phenotype associated with induction of epithelial-mesenchymal transition before differentiation induction; and (ii) a step of acquiring a pluripotent stem cell capable of differentiating into a specific cell using the measured phenotype as an indicator. According to the present invention, there are further provided a method of selecting a pluripotent stem cell capable of differentiating into a specific cell; a pluripotent stem cell capable of differentiating into a specific cell; a production method of a differentiated cell; a differentiated cell; and a method for quality evaluation of a pluripotent stem cell.

Abstract: A vehicle slope apparatus includes a slope plate configured to be moved in a deployment direction so as to be deployed at a lower end of a door opening portion and configured to be moved in a housing direction so as to be housed in a housing portion provided in a vehicle body, and a position holding device configured to hold a position of the slope plate against an external force.

Abstract: The present invention addresses the problem of providing: a method for producing brown adipocytes, osteoblasts, cartilage cells, neural cells, or cardiac cells from somatic cells without performing artificial gene transfer; brown adipocytes, osteoblasts, cartilage cells, neural cells, or cardiac cells; or a composition including a combination of chemical substances that can be used for the aforementioned production method. An example of the present invention is a method for producing brown adipocytes, osteoblasts, cartilage cells, neural cells, or cardiac cells including a step for culturing somatic cells in the presence or absence of an inhibitor or activator selected from the group consisting of an ALK5 inhibitor, an ALK6 inhibitor, an AMPK inhibitor, a cAMP activator, an ALK2 inhibitor, an ALK3 inhibitor, a GSK3 inhibitor, and an Erk inhibitor.

Abstract: There is provided a method including generating a phase contrast image of an aggregate of a pluripotent stem cell from a hologram in which the aggregates is captured; deriving a phase contrast amount density obtained by dividing a total phase contrast amount which is a value obtained by integrating a phase contrast amount of each of a plurality of pixels that constitute the phase contrast image, by a volume of the aggregate; and sorting the pluripotent stem cell based on the phase contrast amount density.

Abstract: There is provided a method including generating a phase contrast image of an aggregate of a pluripotent stem cell from a hologram in which the aggregate is captured; deriving, based on the phase contrast image, an index value indicating a complexity or simplicity of a contour line, the index value being determined according to a relationship between an area of the aggregate and a length of the contour line of the aggregate; and sorting the pluripotent stem cell based on the index value.

Abstract: A first spring array and a second spring array are provided in a holder body. Three sample plates can be mounted in the holder body. On each sample plate, pressing-up forces from the first spring array and the second spring array are applied, but upward movement of each sample plate is restricted by an inner surface of a cover.

Abstract: An imaging device images a sample holder held by a sample stage. At a front side (target side) of the imaging device, a light emitter device array and a mask array are provided. A plurality of light beams are generated by the light emitter device array. A plurality of center parts of the plurality of light beams are masked by the mask array. A plurality of shadows produced thereby are covered by a plurality of peripheral parts of the plurality of light beams.

Abstract: A motor control device controls driving of a motor, which outputs torque to a rack shaft as a load by rotation of a shaft fixed to a rotor. The motor control device has a rotation stress check unit for determining a rotation stress indicating a rotation stress, which is applied inversely from the load to a protection target member such as a shaft, bearing and oil seal related to the rotation of the shaft or torque transmission to the load. The rotation stress check unit determines the rotation stress is excessive based on that an absolute value of a rotation evaluation value exceeds a stress threshold value. The stress threshold value is set to be larger than an absolute value of an upper limit value realized in normal drive control.

Abstract: An object of the present invention is to provide a producing method for a pluripotent stem cell capable of differentiating into a specific cell. According to the present invention, there is provided a producing method for a pluripotent stem cell capable of differentiating into a specific cell. According to the present invention, there is provided a pluripotent stem cell capable of differentiating into a specific cell. According to the present invention, there is provided a producing method for a differentiated cell, and a differentiated cell. According to the present invention, there is provided a method for quality evaluation of a pluripotent stem cell. Further, according to the present invention, there is provided a method of screening a pluripotent stem cell capable of differentiating into a specific cell.

Abstract: First shape data representing a three-dimensional shape of a sample unit including a sample is generated based on a result of three-dimensional shape measurement of the sample. Second shape data representing a three-dimensional shape of a structure which exists in a sample chamber is generated. Movement of the sample unit is controlled based on the first shape data and the second shape data such that collision of the sample unit with the structure does not occur.

Abstract: A slide device includes a lower rail; an upper rail disposed movably with respect to the lower rail; a screw provided on one of the lower rail and the upper rail; and a nut provided on the other one of the lower rail and the upper rail, and engaging the screw, wherein: the upper rail moves relatively with respect to the lower rail in accordance with rotation of at least one of the screw and the nut; the lower rail includes a bottom wall, a side wall extending upward from the bottom wall, and an upper wall extending toward the center in a width direction from the side wall; and the screw or the nut provided on the lower rail has a central axis line which is disposed in a space enclosed by the bottom wall, the side wall, and the upper wall of the lower rail.

Abstract: Provided is an information processing apparatus including an acquiring unit that acquires cell information indicating a state of a cell from production of a pluripotent stem cell to differentiation of the pluripotent stem cell into a specific differentiated cell by differentiation induction, and process history information indicating a history of a processing process for obtaining the differentiated cell, and a deriving unit that derives differentiation potency information indicating differentiation potency of the pluripotent stem cell based on the cell information and the process history information which are acquired by the acquiring unit.

Abstract: A first spring array and a second spring array are provided in a holder body. Three sample plates can be mounted in the holder body. On each sample plate, pressing-up forces from the first spring array and the second spring array are applied, but upward movement of each sample plate is restricted by an inner surface of a cover.

Abstract: An object of the present invention is to provide a method for three-dimensionally culturing a pluripotent stem cell, in which the pluripotent stem cell can maintain good proliferative properties even in a case where the frequency of the medium exchange is reduced. According to the present invention, a method for three-dimensionally culturing a pluripotent stem cell, in which a pluripotent stem cell is cultured in a medium that always contains 35 ng/mL or more of basic fibroblast growth factor until a cell concentration reaches 1.4×106 cells/mL or more, is provided.

Abstract: An object of the present invention is to provide a method for producing a pluripotent stem cell that can efficiently differentiate into a target differentiated cell. According to the present invention, a method for producing a cell is provided, the method including a first step of obtaining an undifferentiated cell which is obtained by introducing a reprogramming factor into a somatic cell and has a relatively low ability to differentiate into a specific differentiated cell; and a second step of treating the cell while maintaining an undifferentiated state of the cell to obtain a cell having a relatively high ability to differentiate into the specific differentiated cell.

Abstract: An imaging device images a sample holder held by a sample stage. At a front side (target side) of the imaging device, a light emitter device array and a mask array are provided. A plurality of light beams are generated by the light emitter device array. A plurality of center parts of the plurality of light beams are masked by the mask array. A plurality of shadows produced thereby are covered by a plurality of peripheral parts of the plurality of light beams.