Abstract: Devices, methods, and systems for placing dental auxiliaries on teeth are provided. In some embodiments, for example, a dental auxiliary positioner for placing a dental auxiliary on a tooth includes: a registration element configured to receive a patient's tooth; and an auxiliary support coupled to the registration element and further coupled to an auxiliary, where the auxiliary support is configured to position the auxiliary against a surface of the tooth, and where the auxiliary support includes a frame extending at least partially around the auxiliary, one or more struts coupling the auxiliary to the frame, and a flexible bridge coupling the frame to the registration element, where the flexible bridge is configured to bend in one or more directions relative to the tooth to adjust the position of the auxiliary on the surface of the tooth.

Abstract: Methods, devices, and systems for placing dental auxiliaries on teeth and/or removing dental auxiliaries from teeth are provided. In some embodiments, a device for removing a dental auxiliary from a tooth includes: a first elongate member having a proximal end and a distal end; a second elongate member having a proximal end and a distal end, where the first and second elongate members are pivotally coupled to each other; a scraper at the distal end of the second elongate member, where the scraper is configured to apply force to the dental auxiliary to remove the dental auxiliary from the tooth; and a pair of sidewalls configured to capture debris resulting from the removal of the dental auxiliary from the tooth.

Abstract: A system for correcting malocclusions may include a maxillary appliance having tooth receiving cavities shaped to receive teeth of a maxilla and a first elastic coupling at gingival line of the maxillary appliance. The first elastic coupling may be configured for receiving an elastic. The system may also include mandibular appliance having tooth receiving cavities shaped to receive teeth of a mandible. The system may also include a corrective appliance having a first coupling configured to be coupled to the mandibular appliance at a first location on a first side of incisors of a patient and a second coupling configured to be coupled to the mandibular appliance on a second side of the incisors, and having an arm extending from the corrective appliance towards the gingival line of the maxillary appliance and being shaped to receive the elastic.

Abstract: Systems and methods for additive manufacturing are provided. In some embodiments, a method for additive manufacturing includes forming a portion of an additively manufactured object within a reservoir of curable material by scanning a plurality of energy beams of a plurality of energy sources through a plurality of respective scanning regions in the curable material. The scanning regions can overlap at one or more object locations, such that a combined energy dosage delivered to the one or more object locations by two or more of the energy beams is greater than or equal to a threshold dosage for solidifying the curable material. The method can further include advancing the reservoir of curable material relative to the energy sources. The forming and advancing processes can be repeated to fabricate the additively manufactured object.

Abstract: A dental attachment placement device comprises a plurality of articulated registration elements shaped for placement on a plurality of teeth, which can facilitate placement, accommodate tooth movement, and improve alignment of the registration elements with the teeth, so as to accurately position an attachment for placement. The plurality of registration elements may comprise one or more attachment supports and one or more retention supports extending from the plurality of registration elements. A dental attachment can be removably coupled to the attachment support. The plurality of registration elements and attachment supports may be located on opposing sides of one or more teeth in order to maintain placement prior to adhering the attachment to the tooth. In some embodiments, each of the plurality of registration elements comprises a tooth registration surface shaped to engage the tooth with a specific position and orientation for accurate positioning of the attachment.

Abstract: Methods and systems for designing dental appliances are provided. In some embodiments, a method includes identifying one or more intended outcomes for one or more areas of a dental appliance, where the dental appliance is shaped to receive and engage with a person's dentition in accordance with a treatment plan; identifying one or more acceptability criteria for evaluating compliance with the one or more intended outcomes; obtaining an appliance model for the dental appliance, where the appliance model represents the one or more areas with one or more first physical properties conforming to the one or more acceptability criteria, and where the one or more first physical properties are different than one or more second physical properties outside the one or more areas; providing three-dimensional (3D) printing instructions to generate the dental appliance using the appliance model; and 3D printing the dental appliance using the 3D printing instructions.

Abstract: Methods for additive manufacturing of polymer and metal dental appliances are provided. In some embodiments, a method includes receiving a digital representation of a dental appliance including a first portion to be formed from a polymeric material and a second portion to be formed from a metallic material. The method can include fabricating the dental appliance using an additive manufacturing process. The additive manufacturing process can include depositing a first composition including a precursor of the polymeric material at the first portion of the dental appliance, and depositing a second composition including a plurality of metal particles at the second portion of the dental appliance.

Abstract: A system may include a body having a palatal portion of a first material and a surface shaped to match a shape of a patient's palate and extending between first tooth engagement structures shaped to engage teeth on a first side of a patient's arch and second tooth engagement structures shaped to engage teeth on a second side of a patient's arch and a reinforcement structure within the palatal portion, wherein the reinforcement structure includes at least one fiber fabricated of a second material, different than the first material, and a dimension of the at least one fiber at a middle portion between respective ends of the at least one fiber is greater than a dimension of the respective ends of the at least one fiber.

Abstract: Methods for designing orthodontic appliances are provided. In some embodiments, a method includes receiving a treatment plan for a patient's dentition and generating an aligner model representing an aligner configured to implement a treatment stage of the treatment plan. The aligner model can include a thickness map having a thickness parameter for each location of the aligner model. The method can include adjusting the thickness map by using the aligner model to evaluate an outcome when the aligner is applied to the patient's dentition, and iteratively reducing the value of each thickness parameter of the thickness map based on the evaluation until a resulting thickness is determined for each thickness parameter. The method can also include providing instructions to manufacture the aligner based on the aligner model with the resulting thickness for each thickness parameter of the thickness map.

Abstract: The disclosed systems, methods, and apparatus for designing, fabricating, and making directly fabricated metal and polymer dental appliances may include receiving patient data and a treatment plan and determining, using the patient data and the treatment plan, an appliance design for treating the patient. The method may include directly fabricating a metal and polymer appliance based on the appliance design. The apparatus may include a directly fabricated metal and polymer appliance.

Abstract: Discloses herein is an activated metal-organic framework of formula as defined in the application, and the metal organic framework has a BET surface area of from 250 to 1,000 m2/g as obtained from a 298 K CO2 sorption isotherm. In a particular embodiment, the activated metal-organic framework is aluminium formate (Al(HCOO)3) or vanadium formate (V(HCOO)3).

Abstract: Systems, methods, and devices for computer-aided design, digital treatment planning, and direct additive manufacturing of dental appliances are provided. In some embodiments, a method includes receiving a treatment plan for a patient's teeth, the treatment plan specifying a target arrangement for the teeth and a plurality of treatment stages to reposition the teeth from an initial arrangement toward the target arrangement. The method can include identifying appliance design parameters for one or more dental appliances to implement at least one treatment stage of the plurality of treatment stages. The appliance design parameters can include one or more manufacturability parameters corresponding to an additive manufacturing process to be used to directly fabricate the one or more dental appliances. The method can further include determining an appliance geometry for the one or more dental appliances using the set of appliance design parameters.

Abstract: Methods and systems for generating support structures for additively manufactured objects are described herein. In some embodiments, a method includes receiving a digital representation of a dental appliance configured to implement a treatment stage of a treatment plan for a patient's teeth. The method can include generating a support structure arrangement configured to support the dental appliance during an additive manufacturing process. The support structure arrangement can be generated using a machine learning model. The machine learning model can be trained on a training data set including appliance data representing geometries of a plurality of dental appliances, support structure data representing geometries of a plurality of support structure arrangements, and outcome data representing outcomes of the additive manufacturing process for the plurality of dental appliances with the respective support structure arrangements.

Abstract: Disclosed herein are methods for the rapid generation of recombinant poxviruses, for example, to enable vaccine development.

Abstract: Apparatuses and methods for assessing a dental x-ray image and predicting tooth eruption and/or exfoliation. The apparatuses may use one or more trained neural networks to assess a patient's x-rays as well as dental measurements determined from the patient's x-rays to predict approximately when a permanent tooth may erupt to replace a baby tooth. The neural networks may be trained using a data training set of x-ray images and accompanying dental measurement data.

Abstract: A resonance control method for differentiated phase correction under asymmetric positive and negative bilateral frequency domains includes a differentiated phase correction resonance control link with an independent phase correction angle at each resonance point, a decoupling link and a delay compensation link. As a high power converter has the characteristic of asymmetric positive and negative bilateral frequency domains under resonance control with decoupling, stability margin of a control link is enhanced while a negative-sequence current suppression capability is realized by means of differentiated phase correction at positive and negative resonance poles.

Abstract: Systems, methods, and devices for computer-aided design, digital treatment planning, and direct additive manufacturing of dental appliances are provided. In some embodiments, a method includes receiving a treatment plan for a patient's teeth, the treatment plan specifying a target arrangement for the teeth and a plurality of treatment stages to reposition the teeth from an initial arrangement toward the target arrangement. The method can include identifying appliance design parameters for one or more dental appliances to implement at least one treatment stage of the plurality of treatment stages. The appliance design parameters can include one or more manufacturability parameters corresponding to an additive manufacturing process to be used to directly fabricate the one or more dental appliances. The method can further include determining an appliance geometry for the one or more dental appliances using the set of appliance design parameters.

Abstract: Methods and systems are provided for generating a treatment plan for arch expansion where a polymeric shell appliance is utilized to generate one or more activation forces that facilitate tooth movement. The polymeric shell appliances may comprise one or more tooth receiving cavities, in which each of the plurality of tooth receiving cavities is shaped and arranged to provide a counter moment of each of the plurality of teeth.

Abstract: Dental appliances and methods for expanding the lower dental arch. The appliances may be removable mandibular expander devices for efficient arch expansion while being comfortable to wear and easy to use. The appliances may include a lingual portion that is shaped and sized to apply an expansion force to lingual surfaces of one or more teeth. The shape and size of the lingual portion may be configured to distribute the forces among posterior and/or anterior teeth.

Abstract: Apparatuses (e.g., distalizers) and methods for distalizing a subject's teeth while preventing or reducing undesirable tipping and/or rotation of the teeth. The distalizer apparatuses may include tooth engagement regions shaped to accommodate molars, canines and/or premolar teeth, may include a transpalatal region extending between engagement regions having an anterior edge that is posterior to a premolar region of the first tooth engagement region, and may include an attachment site for an elastic band on the outer buccal surface.