Abstract: Methods and apparatuses (including software) for optimizing dental treatment plans, including for optimizing the treatment plans using dental aligners. These methods and apparatuses may optimize a treatment plan by estimating a difference between a target set of tooth position and a predicted set of tooth positions using the treatment plan using a prediction network trained to use multiple translational and rotational directions for individual teeth as well as reaction forces on the individual teeth based on adjacent teeth.

Abstract: Methods and systems for producing orthodontic appliances are provided herein utilizing iterative modeling techniques to increase the efficiency and efficacy of said appliances. Further disclosed herein are the orthodontic appliances fabricated from such methods.

Abstract: Embodiments relate to an aligner breakage solution that tests damage to an aligner using machine learning. A method includes of training a machine learning model to predict damage to an orthodontic aligner includes gathering a training dataset comprising digital designs for a plurality of orthodontic aligners, wherein each digital design is associated with a respective orthodontic aligner of the plurality of orthodontic aligners, and wherein each digital design comprises metadata indicating whether the associated respective orthodontic aligner was damaged during manufacturing of the associated respective orthodontic aligner. The method further includes training the machine learning model using the training dataset, wherein the machine learning model is trained to process data from a digital design for an orthodontic aligner and to output a probability that the orthodontic aligner associated with the digital design will be damaged during manufacturing of the orthodontic aligner.

Abstract: Disclosed is device for calibrating oil-water two-phase flow sensor, the device includes a wellbore model, an oil-water separation mechanism, an oil-water mixing mechanism, an oil inlet mechanism and a water inlet mechanism, the oil-water separation mechanism has a mixture inlet, an oil outlet, and a water outlet. The beneficial effect of the technical scheme proposed in the disclosure is: the oil-water mixture flowing out of the wellbore model is separated by an oil-water separation mechanism, and the separated oil and water are introduced into the oil-water mixing mechanism through an oil inlet mechanism and a water inlet mechanism, respectively, for remixing, the oil-water mixture formed by re-mixing enters the wellbore model, and enters the next cycle, which can realize the reuse of oil and water, the miniaturization of the device, and reduction of the production cost of the device.

Abstract: A method for generating and fabricating a dental device having a body. The body may have a first plurality of tooth receiving cavities shaped to receive teeth of a first side of an arch. The body may also have a second plurality of tooth receiving cavities shaped to receive teeth of a second side of an arch. A palatal portion may extend between the first plurality of tooth receiving cavities and the second plurality of tooth receiving cavities. The palatal portion may be shaped to apply an expansion force to the teeth of the first side of the arch and the teeth of the second side of the arch. The palatal portion may include a plurality of bands that extend between the first plurality of tooth receiving cavities and the second plurality of tooth receiving cavities, each respective band may have a respective different thickness.

Abstract: Embodiments relate to an aligner breakage solution that tests damage to an aligner using machine learning. A method includes processing data from a digital design for an orthodontic aligner by a trained machine learning model and outputting, by the trained machine learning model, a probability that the orthodontic aligner associated with the digital design will be damaged during manufacturing of the orthodontic aligner. The method further includes making a comparison of the probability that the orthodontic aligner associated with the digital design will be damaged during manufacturing of the orthodontic aligner to a probability threshold and determining whether the orthodontic aligner is a high risk orthodontic aligner based on a result of the comparison. Responsive to determining that the orthodontic aligner is a high risk orthodontic aligner, the method includes performing at least one of a) a corrective action or b) selecting a manufacturing flow for high risk orthodontic aligners.

Abstract: Embodiments relate to an aligner breakage solution that tests probability of aligner breakage at weak points. A method includes gathering a digital model representing an aligner for a dental arch of a patient, receiving material property information for a material to be used to manufacture the aligner, and analyzing one or more regions of the aligner. Analyzing a region of the aligner comprises simulating application of a load around the region, determining at least one of a stress, a strain or a strain energy density at the region, evaluating a strength of the aligner at the region, and determining whether the region satisfies a damage criterion based on the strength of the aligner at the region.

Abstract: Embodiments relate to an aligner breakage solution that tests progressive damage to an aligner. A method includes gathering a digital model representing an aligner for a dental arch of a patient, and simulating progressive damage to the aligner. Simulating progressive damage for a region of the aligner comprises simulating, using at least the digital model, a sequence of loads on the aligner, determining an amount of damage to the region of the aligner for each load, and after each simulation of a load on the aligner, updating the digital model based on the amount of damage to the region of the aligner. The method further includes determining whether a damage criterion is satisfied for at least one region of the aligner and determining whether to implement one or more corrective actions for the aligner.

Abstract: Disclosed is device for calibrating oil-water two-phase flow sensor, the device includes a wellbore model, an oil-water separation mechanism, an oil-water mixing mechanism, an oil inlet mechanism and a water inlet mechanism, the oil-water separation mechanism has a mixture inlet, an oil outlet, and a water outlet. The beneficial effect of the technical scheme proposed in the disclosure is: the oil-water mixture flowing out of the wellbore model is separated by an oil-water separation mechanism, and the separated oil and water are introduced into the oil-water mixing mechanism through an oil inlet mechanism and a water inlet mechanism, respectively, for remixing, the oil-water mixture formed by re-mixing enters the wellbore model, and enters the next cycle, which can realize the reuse of oil and water, the miniaturization of the device, and reduction of the production cost of the device.

Abstract: A resonance control method for differentiated phase correction under asymmetric positive and negative bilateral frequency domains includes a differentiated phase correction resonance control link with an independent phase correction angle at each resonance point, a decoupling link and a delay compensation link. As a high power converter has the characteristic of asymmetric positive and negative bilateral frequency domains under resonance control with decoupling, stability margin of a control link is enhanced while a negative-sequence current suppression capability is realized by means of differentiated phase correction at positive and negative resonance poles.

Abstract: The disclosure provides resins, polymeric materials, and devices incorporating force probes. Advantageously, the force probes emit an emission useful for determining the amount of force or stress applied to a material incorporated with force probes. Further, the present disclosure provides methods of detecting forces and stress applied to force probe incorporated materials. Materials such as orthodontic appliances comprising force probes possess particular advantage and utility as measurement of the emission of the orthodontic appliance(s) from a patient can aid in evaluating treatment progress.

Abstract: Computer-implemented methods and systems for designing oral appliances. These methods and systems may include receiving patient data and a treatment plan (including a proposed one or more dental appliances), and determining, using the patient data and the treatment plan, an improved appliance design for treating the patient. These methods and systems may include evaluating the appliance design based on simulation and finalizing the appliance design based on the evaluation.

Abstract: Embodiments relate to an aligner breakage solution. A method includes obtaining a digital design of a polymeric aligner for a dental arch of a patient. The polymeric aligner is shaped to apply forces to teeth of the dental arch. The method also includes performing an analysis on the digital design of the polymeric aligner using at least one of a) a trained machine learning model, b) a numerical simulation, c) a geometry evaluator or d) a rules engine. The method may also include determining, based on the analysis, whether the digital design of the polymeric aligner includes probable points of damage, wherein for a probable point of damage there is a threshold probability that breakage, deformation, or warpage will occur. The method may also include, responsive to determining that the digital design of the polymeric aligner comprises probable points of damage, performing corrective actions based on the probable points of damage.

Abstract: Disclosed herein are methods for the rapid generation of recombinant viruses, for example, to enable vaccine development.

Abstract: A system for correcting class III malocclusions is disclosed. The system may include a maxilla appliance having tooth receiving cavities shaped to receive teeth of the maxilla and a first coupling for receiving an elastic. The system may also include a mandibular appliance having tooth receiving cavities shaped to receive teeth of the mandible. In some embodiments, the system includes a class III corrective appliance having a first mount shaped to engage with the mandibular arch of the patient and having a second coupling shaped to receive the elastic.

Abstract: A non-invasive detection method, device, system and wearable apparatus for tissue element are provided. The method includes: emitting incident light of multiple predetermined wavelengths to a detected site, respectively; for each predetermined wavelength, obtaining light intensity values emitted from a surface of the detected site based on multiple photosensitive surfaces, wherein multiple photosensitive surfaces are at predetermined distances from a center of the incident light; and determining a concentration of the tissue element to be detected according to light intensity values in multiple predetermined wavelengths.

Abstract: The disclosed systems, methods, and apparatus for designing, fabricating, and making directly fabricated metal and polymer dental appliances may include may include receiving patient data and a treatment plan and determining, using the patient data and the treatment plan, an appliance design for treating the patient. The method may include directly fabricating a metal and polymer appliance based on the appliance design. The apparatus may include a directly fabricated metal and polymer appliance.

Abstract: A dental attachment placement device comprises a plurality of registration elements shaped for placement on a plurality of teeth and one or more flexible arms for biasing the registration element to a tooth. A first a first flexible arm may extend from a registration element on a lingual side. The first flexible arm may have a connected end and a distal end. The distal end may be configured to extend at least part way over the tooth and apply a lingual force to bias the registration element against the tooth.

Abstract: A dental attachment placement device comprises a plurality of articulated registration elements shaped for placement on a plurality of teeth, which can facilitate placement, accommodate tooth movement, and improve alignment of the registration elements with the teeth, so as to accurately position an attachment for placement. The plurality of registration elements may comprise one or more attachment supports and one or more retention supports extending from the plurality of registration elements. A dental attachment can be removably coupled to the attachment support. The plurality of registration elements and attachment supports may be located on opposing sides of one or more teeth in order to maintain placement prior to adhering the attachment to the tooth. In some embodiments, each of the plurality of registration elements comprises a tooth registration surface shaped to engage the tooth with a specific position and orientation for accurate positioning of the attachment.

Abstract: A dental attachment placement device comprises a plurality of articulated registration elements shaped for placement on a plurality of teeth, which can facilitate placement, accommodate tooth movement, and improve alignment of the registration elements with the teeth, so as to accurately position an attachment for placement. An orthodontic device may include a plurally of registration element. A plurality of first flexible arms may extend from each registration element on a lingual side. The first flexible arm may have a connected end and a distal end. The distal end may be configured to extend at least part way over the tooth and apply a lingual force to bias the registration element against the tooth. A plurality of attachment supports may each be located on a buccal side of the plurally of registration elements and include an attachment frame that is releasably coupled to an attachment.