Abstract: Systems, methods, and devices for computer-aided design, digital treatment planning, and direct additive manufacturing of dental appliances are provided. In some embodiments, a method includes receiving a treatment plan for a patient's teeth, the treatment plan specifying a target arrangement for the teeth and a plurality of treatment stages to reposition the teeth from an initial arrangement toward the target arrangement. The method can include identifying appliance design parameters for one or more dental appliances to implement at least one treatment stage of the plurality of treatment stages. The appliance design parameters can include one or more manufacturability parameters corresponding to an additive manufacturing process to be used to directly fabricate the one or more dental appliances. The method can further include determining an appliance geometry for the one or more dental appliances using the set of appliance design parameters.

Abstract: Methods and systems are provided for generating a treatment plan for arch expansion where a polymeric shell appliance is utilized to generate one or more activation forces that facilitate tooth movement. The polymeric shell appliances may comprise one or more tooth receiving cavities, in which each of the plurality of tooth receiving cavities is shaped and arranged to provide a counter moment of each of the plurality of teeth.

Abstract: Dental appliances and methods for expanding the lower dental arch. The appliances may be removable mandibular expander devices for efficient arch expansion while being comfortable to wear and easy to use. The appliances may include a lingual portion that is shaped and sized to apply an expansion force to lingual surfaces of one or more teeth. The shape and size of the lingual portion may be configured to distribute the forces among posterior and/or anterior teeth.

Abstract: Apparatuses (e.g., distalizers) and methods for distalizing a subject's teeth while preventing or reducing undesirable tipping and/or rotation of the teeth. The distalizer apparatuses may include tooth engagement regions shaped to accommodate molars, canines and/or premolar teeth, may include a transpalatal region extending between engagement regions having an anterior edge that is posterior to a premolar region of the first tooth engagement region, and may include an attachment site for an elastic band on the outer buccal surface.

Abstract: Methods and apparatuses for generating ortho-restorative treatment plans and orthodontic aligners. The ortho-restorative treatment plan may include prescribed movements of one or more teeth to correct mal-positioned teeth while accounting for planned restorative treatments on a patient's dentition. The methods may include forming a virtual target dentition model having a target restorative feature, and one or more virtual intermediate dentition models having one or more intermediate restorative features having a different shape and/or size as the target restorative feature. The methods may be used generate a series of aligners in accordance with the ortho-restorative treatment plan.

Abstract: According to the techniques herein, one or more sensors coupled to an aligner are used to sense one or more physical qualities of the aligner to determine whether the physical qualities indicate that the aligner material has relaxed and has, e.g., reduced the force systems applied to teeth and/or that the teeth movement for the stage has slowed down. The sensors may provide a signal that represents whether or not the physical qualities fall below a threshold value. A treatment plan may be modified if needed. These techniques have the potential to make treatment plans faster and more effective by speeding up some stages while making sure some, perhaps other, stages are implemented only after the teeth are near the appropriate position.

Abstract: Methods and apparatuses for retaining or treating a dental arch to apply a lateral expansion force to a lower jaw while permitting the extrusion of one or more teeth may include the use of a maxillary dental appliance device and/or a mandibular dental appliance device including projection regions extending from the occlusal surfaces of the device to apply a laterally outward expansion force.

Abstract: A system for correcting class III malocclusions is disclosed. The system may include a maxilla appliance having tooth receiving cavities shaped to receive teeth of the maxilla and a first coupling for receiving an elastic. The system may also include a mandibular appliance having tooth receiving cavities shaped to receive teeth of the mandible. In some embodiments, the system includes a class III corrective appliance having a first mount shaped to engage with the mandibular arch of the patient and having a second coupling shaped to receive the elastic.

Abstract: Methods and systems are provided for generating a treatment plan for arch expansion where a polymeric shell appliance is utilized to generate one or more activation forces that facilitate tooth movement. The polymeric shell appliances may comprise one or more tooth receiving cavities, in which each of the plurality of tooth receiving cavities is shaped and arranged to provide a counter moment of each of the plurality of teeth.

Abstract: A system for correcting class III malocclusions is disclosed. The system may include a maxilla appliance having tooth receiving cavities shaped to receive teeth of the maxilla and a first coupling for receiving an elastic. The system may also include a mandibular appliance having tooth receiving cavities shaped to receive teeth of the mandible. In some embodiments, the system includes a class III corrective appliance having a first mount shaped to engage with the mandibular arch of the patient and having a second coupling shaped to receive the elastic.

Abstract: According to the techniques herein, one or more sensors coupled to an aligner are used to sense one or more physical qualities of the aligner to determine whether the physical qualities indicate that the aligner material has relaxed and has, e.g., reduced the force systems applied to teeth and/or that the teeth movement for the stage has slowed down. The sensors may provide a signal that represents whether or not the physical qualities fall below a threshold value. A treatment plan may be modified if needed. These techniques have the potential to make treatment plans faster and more effective by speeding up some stages while making sure some, perhaps other, stages are implemented only after the teeth are near the appropriate position.

Abstract: A method for use in additively manufacturing an orthodontic aligner may include receiving a digital model of an aligner, processing the digital model of the aligner to modify the digital model based on predicted deviations during fabrication to generate a first updated digital model of the aligner, determining that whether the predicted deviations of a physical aligner additively manufactured based on the first updated digital model of the aligner are acceptable, and outputting the first updated digital model of the aligner for fabrication of the physical aligner by additive manufacture of the physical aligner.

Abstract: Disclosed herein are flavivirus signal peptide mutants useful for enhancing the production and secretion of flavivirus envelope (E) viral proteins or virus-like proteins. Also disclosed herein are methods of vaccinating subjects (e.g.

Abstract: A system for correcting class III malocclusions is disclosed. The system may include a maxilla appliance having tooth receiving cavities shaped to receive teeth of the maxilla and a first coupling for receiving an elastic. The system may also include a mandibular appliance having tooth receiving cavities shaped to receive teeth of the mandible. In some embodiments, the system includes a class III corrective appliance having a first mount shaped to engage with the mandibular arch of the patient and having a second coupling shaped to receive the elastic.

Abstract: Methods for designing orthodontic appliances are provided. In some embodiments, a method includes receiving a treatment plan for a patient's dentition and generating an aligner model representing an aligner configured to implement a treatment stage of the treatment plan. The aligner model can include a thickness map having a thickness parameter for each location of the aligner model. The method can include adjusting the thickness map by using the aligner model to evaluate an outcome when the aligner is applied to the patient's dentition, and iteratively reducing the value of each thickness parameter of the thickness map based on the evaluation until a resulting thickness is determined for each thickness parameter. The method can also include providing instructions to manufacture the aligner based on the aligner model with the resulting thickness for each thickness parameter of the thickness map.

Abstract: Apparatuses and methods for customized retainers to prevent relapse. In particular, described herein are customized retainers, and methods and apparatuses for making customized retainers that specifically reenforce and prevent movement of one or more teeth having a higher likelihood of relapse following completion of an orthodontic treatment plan.

Abstract: Methods and apparatuses (including software) for optimizing dental treatment plans, including for optimizing the treatment plans using dental aligners. These methods and apparatuses may optimize a treatment plan by estimating a difference between a target set of tooth position and a predicted set of tooth positions using the treatment plan using a prediction network trained to use multiple translational and rotational directions for individual teeth as well as reaction forces on the individual teeth based on adjacent teeth.

Abstract: Methods and systems for producing orthodontic appliances are provided herein utilizing iterative modeling techniques to increase the efficiency and efficacy of said appliances. Further disclosed herein are the orthodontic appliances fabricated from such methods.

Abstract: Embodiments relate to an aligner breakage solution that tests damage to an aligner using machine learning. A method includes of training a machine learning model to predict damage to an orthodontic aligner includes gathering a training dataset comprising digital designs for a plurality of orthodontic aligners, wherein each digital design is associated with a respective orthodontic aligner of the plurality of orthodontic aligners, and wherein each digital design comprises metadata indicating whether the associated respective orthodontic aligner was damaged during manufacturing of the associated respective orthodontic aligner. The method further includes training the machine learning model using the training dataset, wherein the machine learning model is trained to process data from a digital design for an orthodontic aligner and to output a probability that the orthodontic aligner associated with the digital design will be damaged during manufacturing of the orthodontic aligner.

Abstract: Disclosed is device for calibrating oil-water two-phase flow sensor, the device includes a wellbore model, an oil-water separation mechanism, an oil-water mixing mechanism, an oil inlet mechanism and a water inlet mechanism, the oil-water separation mechanism has a mixture inlet, an oil outlet, and a water outlet. The beneficial effect of the technical scheme proposed in the disclosure is: the oil-water mixture flowing out of the wellbore model is separated by an oil-water separation mechanism, and the separated oil and water are introduced into the oil-water mixing mechanism through an oil inlet mechanism and a water inlet mechanism, respectively, for remixing, the oil-water mixture formed by re-mixing enters the wellbore model, and enters the next cycle, which can realize the reuse of oil and water, the miniaturization of the device, and reduction of the production cost of the device.