Abstract: Provided are an image processing method, apparatus and system, a network device, a terminal and a storage medium. The method includes: acquiring composition indication information for indicating a composition and display manner of regions of interest (ROIs) in a video image; and generating a media stream of the video image based on at least the composition indication information, i.e., writing the composition indication information into a code stream of the video image.

Abstract: Provided is an image encoding method. The method includes: determining an intra prediction mode of an encoding block, and constructing a first prediction value of the encoding block according to the intra prediction mode; determining a filtering parameter according to the first prediction value and an original value of the encoding block, where the filtering parameter includes a filtering indication parameter; in a case where the filtering indication parameter indicates performing filtering processing on the first prediction value, performing the filtering processing on the first prediction value to obtain an intra prediction value; calculating a prediction difference parameter according to a difference between the original value of the encoding block and the intra prediction value; and encoding the intra prediction mode, the filtering parameter, and the prediction difference parameter, and writing encoded bits into a bitstream.

Abstract: Embodiments described herein relate to compositions including genetically modified CAR cells and uses thereof for treating cancer. Some embodiments of the present disclosure relate to compositions and methods for T cell response enhancement and/or CAR cell preparation. For example, a method may include obtaining cells comprising a CAR and culturing the cells in the presence of an agent that is recognized by the extracellular domain of the CAR.

Abstract: Provided in embodiments of the present disclosure are a media data processing method, an apparatus and a system. The method comprises: obtaining an optical signal of a sampling point by a collection device at the source end in an acquisition of media data; acquiring an optical signal intensity of the optical signal of the sampling point and a display brightness of a display device at destination end; determining an opto-electronic transfer control parameter according to the optical signal intensity of the optical signal of the sampling point and the display brightness; performing opto-electronic transfer on the optical signal of the sampling point according to the opto-electronic transfer control parameter to obtain a transferred electrical signal; and encoding the electrical signal and the opto-electronic transfer control parameter to obtain a bitstream.

Abstract: Disclosed are an image coding and decoding methods, an image processing device, and a computer storage medium. The image coding method comprises: obtaining a dynamic range of a copy parameter of a current coding sampling value segment according to a size of a reference area; and coding the copy parameter according to the dynamic range to generate a video bitstream containing information about the size of the reference area and information about the copy parameter. The decoding method comprises: parsing a video bitstream to obtain a dynamic range of a copy parameter of a decoding sampling value segment; and decoding the copy parameter according to the dynamic range.

Abstract: Embodiments relate to a method for increasing or maintaining a population of memory T-cells. The method includes introducing T-cells with a nucleic acid encoding a chimeric antigen receptor (CAR), wherein the CAR includes an extracellular domain, a transmembrane domain, and an intracellular domain, and the extracellular domain binds an antigen; introducing into the T-cells a nucleic acid encoding a modified PD-1, wherein the modified PD-1 lacks a functional PD-1 intracellular domain; and administering an effective amount of a composition comprising the T-cells to a subject having cancer.

Abstract: Several embodiments of the present invention are described for a media data processing method, apparatus and system. An example method comprises: obtaining an optical signal of a sampling point by a collection device at the source end in an acquisition of media data; according to an opto-electronic transfer control parameter, performing opto-electronic transfer for the optical signal of the sampling point to obtain a transferred electrical signal, wherein the opto-electronic transfer control parameter is determined on the basis of an optical signal intensity of the optical signal of the sampling point; and encoding the electrical signal and opto-electronic transfer control parameter to obtain a bitstream. According to the embodiment of the present invention, the problem of the lower accuracy in the media data processing is solved, thereby obtaining the effect of improving the accuracy in the media data processing.

Abstract: Disclosed are an image coding and decoding methods, an image processing device, and a computer storage medium. The image coding method comprises: obtaining a dynamic range of a copy parameter of a current coding sampling value segment according to a size of a reference area; and coding the copy parameter according to the dynamic range to generate a video bitstream containing information about the size of the reference area and information about the copy parameter. The decoding method comprises: parsing a video bitstream to obtain a dynamic range of a copy parameter of a decoding sampling value segment; and decoding the copy parameter according to the dynamic range.

Abstract: A method and apparatus for decoding a video bitstream, a method and apparatus for generating a video bitstream, storage medium and an electronic device are provided. The method for decoding the video bitstream includes that: a first parameter of a reference position of a slice in a video picture is acquired; a second parameter of the slice is acquired, the second parameter being used for determining a starting position of the slice in the video picture; and a starting position coordinate parameter of the slice in the video picture is calculated according to the first parameter and the second parameter.

Abstract: Techniques for encoding or decoding digital video or pictures include acquiring a video bitstream that includes an encoded video image that is a two-dimensional image comprising multiple regions of a panoramic image in three-dimensional coordinates, extracting neighboring information for the multiple regions, performing, using the neighboring information, post-processing of a video image decoded from the video bitstream, and generating a display image from the video image after the post-processing.

Abstract: The present disclosure relates to compositions and methods for treating cancer. For example, a modified cell may include a polynucleotide comprising an NFAT promoter, a nucleotide sequence encoding therapeutic agent, and a nucleotide sequence encoding a VHL-interaction domain of HIF1?, wherein the therapeutic agent comprises, for example, IL-12, IL-6, and/or IFN?.

Abstract: Devices, systems and methods for deriving intra prediction samples when the intra prediction mode for a coding block is the planar mode are described. In an aspect, a method for video coding includes selecting a first set of reference samples that are reconstructed neighboring samples of a current block, and determining a prediction value for a prediction sample of the current block by interpolating at least one of the first set and a second set of reference samples, where a reference sample of the second set of reference samples is based on a weighted sum of a first sample and a second sample from the first set of reference samples, and where the reference sample is aligned horizontally with the first sample, aligned vertically with the second sample, and positioned on an opposite side of the prediction sample with respect to either the first or the second sample.

Abstract: The present disclosure relates to compositions and methods for compositions, methods, and kits for treating cancer using modified T cells in which TRAC genes are inactivated using a Zinc-finger nuclease (ZFN). The ZFN may include a first zinc finger protein (ZFP) that binds a first target site in a T-cell receptor alpha constant (TRAC) gene and a second ZFP that binds a second target site in the TRAC gene.

Abstract: The present disclosure provides a method and device for image coding and a method and device for image decoding, and the method includes: a representative pixel set of a coding block is constructed, and information for constructing the representative pixel set is determined; predicted values of pixel samples in the coding block are constructed, a generation manner for the predicted values including: constructing the predicted values of the pixel samples according to reconstructed pixel samples in an image region outside the coding block and pixel values of the representative pixel set; and the information for constructing the representative pixel set and information for constructing the predicted values are coded and written into a video bitstream.

Abstract: Techniques for encoding, decoding, and extracting one or more bitstreams to form one or more sub-bitstreams are described. In one example aspect, a method for video or picture processing includes partitioning a picture into one or more tiles and generating one or more bitstreams using one or more configurations based on the one or more tiles. Generating each of the one or more bitstreams includes partitioning each of the one or more tiles into one or more slices, and performing, for each slice among the one or more slices a first encoding step to encode a tile identifier in a header of the slice, and a second encoding step to encode, in the header of the slice, a second address of the slice that indicates a location of the slice in the tile.

Abstract: The present disclosure relates to compositions and methods for compositions, methods, and kits for treating cancer using modified T cells in which TRAC genes are inactivated using a Zinc-finger nuclease (ZFN). The ZFN may include a first zinc finger protein (ZFP) that binds a first target site in a T-cell receptor alpha constant (TRAC) gene and a second ZFP that binds a second target site in the TRAC gene.

Abstract: Disclosed are an encoding processing method and device, a decoding processing method and device, an encoder and a decoder. The encoding processing method includes: determining a filtering process to be applied to a pixel in a prediction reference block for an encoding block; filtering the pixel in the prediction reference block according to the filtering process; constructing a pixel prediction value for the encoding block according to a filtered pixel sampling value in the prediction reference block; and encoding the encoding block according to the pixel prediction value.

Abstract: The present disclosure provides picture encoding and decoding methods, picture encoding and decoding devices as well as a decoder and an encoder. The picture decoding method includes: parsing a video bitstream to obtain candidate reshaping parameters from a picture-layer and/or slice-layer data unit of the video bitstream, and determining a reshaping parameter used for reshaping a reconstructed picture according to the obtained candidate reshaping parameters; and reshaping the reconstructed picture by using the reshaping parameter. The reconstructed picture is a picture obtained by decoding the video bitstream before performing the reshaping.

Abstract: The present disclosure relates to compositions and methods for enhancing T cell response and/or CAR cell expansion and/or maintenance in vivo and/or in vitro. For example, in a method of in vivo cell expansion, the method comprises administering an effective amount of cells comprising an antigen binding molecule to a subject; and administering an effective amount of presenting cells expressing a solid tumor antigen that the binding molecule binds.

Abstract: The present disclosure relates to compositions and methods for reducing immune tolerance associated with CAR T cell therapy. Embodiments of the present disclosure include isolated nucleic acid sequence comprising a nucleic acid sequence that encodes modified programmed cell death protein 1 (PD-1) and a nucleic acid sequence that encodes chimeric antigen receptor (CAR).