Publication number: 20240277874
Abstract: A fluorescence-magnetic resonance dual-modality contrast agent, a preparation method thereof and the use thereof. The contrast agent has the following structure: X-L-Y, wherein: formula (I); R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, and R12 are each independently selected from H, halogen, OH, NH2, COOH, CONH2, NO2, CN, and low alkyl groups, the low alkyl groups can be substituted with halogen, OH, NH2, COOH, CONH2, SO3H, NO2, and CN, wherein R3 and R4, taken together with the carbon atoms to which they are attached, may form a phenyl group or a heterocyclic group; R7 and R8, taken together with the carbon atoms to which they are attached, may form a phenyl group or heterocyclic group; L is a linking group; and Y is a metal chelate.
Type:
Application
Filed:
April 26, 2022
Publication date:
August 22, 2024
Applicants:
HAINAN POLY PHARMACEUTICAL CO., LTD., ZHEJIANG POLY PHARMACEUTICAL CO., LTD.
Inventors:
Yuxin HAN, Yifan ZHU, Minhua FAN, Zhen ZHANG, Xinglong ZHU