Patents by Inventor Zhi Hong

Zhi Hong has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Diaryl-purines, azapurines and -deazapurines as non-nucleoside reverse transcriptase inhibitor for treatment of HIV
    Patent number: 8227601
    Abstract: This application concerns certain 2-phenylamino-6-aryl amino-, 6-aryloxy-, and 6-arylthio-purines, -azapurines and -deazapurines. These compounds are non-nucleoside reverse transcriptase inhibitors and have potential as anti-HIV treatment.
    Type: Grant
    Filed: May 5, 2006
    Date of Patent: July 24, 2012
    Assignee: Ardea Biosciences, Inc.
    Inventors: Jean-Luc Girardet, Yung-Hyo Koh, Stephanie Shaw, Hong Woo Kim, Zhi Hong
  • Substituted thieno[3,2-d]pyrimidines as HIV inhibitors
    Patent number: 8211898
    Abstract: This application concerns certain 4-cyanophenylamino-substituted bicyclic heterocycles of formula I where the dashed line represents a double bond that may be located either between A and C(V) or between C(V) and D, where A is S or C(Z); D is S or C(W); provided that one and only one of A and D is S; where T is NH, O, or S; and where other substituents are defined herein. These compounds are non-nucleoside reverse transcriptase inhibitors and have potential as anti-HIV treatment.
    Type: Grant
    Filed: July 16, 2009
    Date of Patent: July 3, 2012
    Assignee: Ardea Biosciences, Inc.
    Inventors: Jean-Luc Girardet, Zhi Hong, Stephanie Shaw, Yung-hyo Koh
  • N[S(4-ARYL-TRIAZOL-3-YL)ALPHA-MERCAPTOACETYL]-P-AMINO BENZOIC ACIDS AS HIV REVERSE TRANSCRIPTASE INHIBITORS
    Publication number: 20120077981
    Abstract: A series of S-triazolyl ?-mercaptoacetanilides having N-(?-mercaptoacetyl) p amino benzoic acid derivatives. are provided, where Q is CO2H, or a salt or ester thereof, or a C(O) N-linked amino acid. The compounds inhibit several variants of the reverse transcriptase of HIV, and are useful in the treatment of HIV infections.
    Type: Application
    Filed: December 6, 2011
    Publication date: March 29, 2012
    Applicant: Ardea Biosciences Inc.
    Inventors: Jean-Luc Girardet, Yung-hyo Koh, Martha de la Rosa, Zhi Hong, Stanley Lang
  • HUMAN-MACHINE INTERFACE BASED ON TASK-SPECIFIC TEMPORAL POSTURAL SYNERGIES
    Publication number: 20120078381
    Abstract: A synergy-based human-machine interface that uses low-dimensional command signals to control a high dimensional virtual, robotic or paralyzed human hand is provided. Temporal postural synergies are extracted from angular velocities of finger joints of five healthy subjects when they perform hand movements that are similar to activities of daily living. Extracted Synergies are used in real-time brain control, where a virtual, robotic or paralyzed human hand is controlled to manipulate virtual or real world objects.
    Type: Application
    Filed: September 27, 2011
    Publication date: March 29, 2012
    Applicant: University of Pittsburgh - Of the Commonwealth System of Higher Education
    Inventors: Ramana Kumar Vinjamuri, Wei Wang, Zhi-Hong Mao, Douglas John Weber
  • COMPOUNDS FROM SOFT CORAL, METHOD OF PREPARATION AND PHARMACEUTICAL USES THEREOF
    Publication number: 20120071547
    Abstract: The invention relates to compounds from the soft coral and the generation thereof. The invention also relates to the uses of the compounds from the soft coral in inhibiting inducible nitric oxide synthase and/or cyclooxygenase-2 and in treating the diseases associated with inducible nitric oxide synthase and/or cyclooxygenase-2.
    Type: Application
    Filed: March 15, 2011
    Publication date: March 22, 2012
    Applicants: NATIONAL MUSEUM OF MARINE BIOLOGY & AQUARIUM, NATIONAL SUN YAT-SEN UNIVERSITY
    Inventors: JYH-HORNG SHEU, WEI-HSIEN WANG, ZHI-HONG WEN, BO-WEI CHEN, PING-JYUN SUNG
  • Dihydromyricetin as an IKK-beta inhibitor used for treatment of arthritis, cancer and autoimmune conditions, and other diseases or disorders
    Publication number: 20120053235
    Abstract: Use of dihydromyricetin (DMY) as an NF-?B inhibitor or an IKK-? inhibitor for the treatment of arthritis, cancer, autoimmune conditions and other disease is provided. A pharmaceutical composition comprising DMY is also provided.
    Type: Application
    Filed: August 3, 2011
    Publication date: March 1, 2012
    Applicant: HONG KONG BAPTIST UNIVERSITY
    Inventors: Liang LIU, Hua ZHOU, Ting LI, Kam Wai WONG, Zhi Hong JIANG
  • System and method for controlling downloading web pages
    Patent number: 8117536
    Abstract: A system for controlling downloading web pages is disclosed. The system parses a current web page to generate information about the web pages pointed to by the selected links in the current web page. A number of the selected links and the number of script commands is counted and information about each of the web pages pointed to by the selected links is obtained. Script commands are used for downloading the web pages pointed to by the selected links. The system also switching to a next page of the current web page if the current web page comprises two or more pages, and if the number of the script commands equals the number of the selected links.
    Type: Grant
    Filed: August 8, 2008
    Date of Patent: February 14, 2012
    Assignees: Hong Fu Jin Precision Industry (ShenZhen) Co., Ltd., Hon Hai Precision Industry Co., Ltd.
    Inventors: Chung-I Lee, Chien-Fa Yeh, Da-Peng Li, Zhi-Hong Li
  • N[S(4-aryl-triazol-3-yl)?-mercaptoacetyl]-amino benzoic acids as HIV reverse transcriptase inhibitors
    Patent number: 8106205
    Abstract: A series of S-triazolyl ?-mercaptoacetanilides having N-(?-mercaptoacetyl) p amino benzoic acid derivatives. are provided, where Q is CO2H, or a salt or ester thereof, or a C(O) N-linked amino acid. The compounds inhibit several variants of the reverse transcriptase of HIV, and are useful in the treatment of HIV infections.
    Type: Grant
    Filed: February 2, 2010
    Date of Patent: January 31, 2012
    Assignee: Ardea Biosciences, Inc.
    Inventors: Jean-Luc Girardet, Yung-hyo Koh, Martha De La Rosa, Zhi Hong, Stanley Lang
  • DERIVATIVES OF N-(ARYLAMINO)SULFONAMIDES AS INHIBITORS OF MEK
    Publication number: 20120022076
    Abstract: This invention concerns N-(2-arylamino)aryl sulfonamides, which are inhibitors of MEK and are useful in treatment of cancer and other hyperproliferative diseases.
    Type: Application
    Filed: September 23, 2011
    Publication date: January 26, 2012
    Inventors: Andreas MADERNA, Jean-Michel Vernier, Dinesh Barawkar, Varaprasad Chamakura, Hassan El Abdellaoul, Dinesh Barawkar, Zhi Hong
  • Derivatives of N-(arylamino) sulfonamides as inhibitors of MEK
    Patent number: 8101799
    Abstract: This invention concerns N—(2-arylamino) aryl sulfonamides, which are inhibitors of MEK and are useful in treatment of cancer and other hyperproliferative diseases.
    Type: Grant
    Filed: July 30, 2007
    Date of Patent: January 24, 2012
    Assignee: Ardea Biosciences
    Inventors: Andreas Maderna, Jean-Michel Vernier, Dinesh Barawkar, Varaprasad Chamakura, Hassan El Abdellaoui, Zhi Hong
  • S-TRIAZOLYL ALPHA-MERCAPTO ACETANILIDES AS INHIBITORS OF HIV REVERSE TRANSCRIPTASE
    Publication number: 20110313157
    Abstract: A series of S-triazolyl ?-mercaptoacetanilides having general structure (1) are provided, where Q is CO2H, CONR2, SO3H, or SO2NR2. The compounds inhibit several variants of the reverse transcriptase of HIV, and are useful in the treatment of HIV infections.
    Type: Application
    Filed: June 30, 2011
    Publication date: December 22, 2011
    Applicant: ARDEA BIOSCIENCES INC.
    Inventors: Jean-Luc Girardet, Yung-Hyo Koh, Martha De La Rosa, Esmir Gunic, Zhi Hong, Stanley Lang, Woo-Hong Kim
  • Inhibitors of MEK
    Patent number: 8063049
    Abstract: This invention concerns to N-(2-aylamino)aryl sulfonamides, which are inhibitors of MEK, methods of using such compounds in the treatment of hyperproliferative diseases, and to pharmaceutical compositions containing such compounds.
    Type: Grant
    Filed: September 10, 2010
    Date of Patent: November 22, 2011
    Assignee: Ardea Biosciences, Inc.
    Inventors: Yung-hyo Koh, Zhi Hong, Jean-Michel Vernier, Andreas Maderna
  • Electrical connector with a metallic shell with a mating opening divided into two different interfaces
    Patent number: 8052469
    Abstract: Provided is an electrical connector including an insulative housing having a main body and a pair of tongue plates perpendicular extending from said main body along a mating direction. Said tongue plates are parallel to each other and each defines a plurality of terminal grooves thereon. A plurality of terminals are received in the terminal grooves. A metallic shell is retained on the main body of the insulative housing and encloses said pair of tongue plates thereby defining a mating opening therein. The mating opening defines a first and a second different interfaces in communication with each other. At least a partition portion protrudes toward the mating opening from said main body and defines a bottom surface to act as a top wall of the second interface.
    Type: Grant
    Filed: November 30, 2009
    Date of Patent: November 8, 2011
    Assignee: Hon Hai Precision Ind. Co., Ltd.
    Inventors: Yu-Hua Mao, Zhi-Hong Fang, Fa-Chun Wang
  • System and method for downloading text content and images in web pages
    Patent number: 8041732
    Abstract: A computer-based method for downloading text content and images in web pages is provided. The method includes downloading a web page as a temporary extensible markup language (XML) file in an application server, and searching the temporary XML file for predetermined information in the temporary XML file. The method further includes searching the temporary XML file for text content in the temporary XML file. Furthermore, the method includes converting a relative path of the image uniform resource locator (URL) to an absolute path by joining the URL of the web page to the front of the relative path of the image URL, and generating a local path for each image in the temporary XML file and storing each image into an application server according to the local path.
    Type: Grant
    Filed: December 9, 2008
    Date of Patent: October 18, 2011
    Assignees: Hong Fu Jin Precision Industry (ShenZhen) Co., Ltd., Hon Hai Precision Industry Co., Ltd.
    Inventors: Chung-I Lee, Chien-Fa Yeh, Da-Peng Li, Zhi-Hong Li
  • RESONANT CONVERTING DEVICE, AND CONTROL MODULE AND METHOD FOR CONTROLLING A RESONANT CONVERTER
    Publication number: 20110249473
    Abstract: A method for controlling operation of a resonant converter is to be implemented by a control module that generates a drive signal for controlling a power switch of the resonant converter to thereby control an output voltage and an output current provided by the resonant converter to a load. The method includes: (A) configuring the control module to determine if the load is operating in a first mode or a second mode; (B) configuring the control module to generate the drive signal according to the output voltage when the control module determines that the load is operating in the first mode; and (C) configuring the control module to generate the drive signal according to the output current when the control module determines that the load is operating in the second mode.
    Type: Application
    Filed: September 27, 2010
    Publication date: October 13, 2011
    Applicant: SILITEK ELECTRONIC (GUANGZHOU) CO., LTD.
    Inventors: MING-ZHU LI, JING-YAN LI, QING-LIN ZHAO, ZHI-HONG YE, CHUN-LIN ZHANG
  • Methods of treating cancer with an antibody-drug conjugate
    Patent number: 8034959
    Abstract: The present invention provides analogues of duocarmycins that are potent cytotoxins. Also provided are peptidyl and disulfide linkers that are cleaved in vivo. The linkers are of use in forming prodrugs and conjugates of the cytotoxins of the invention as well as other diagnostic and therapeutic moieties. The invention provides prodrugs and conjugates of the duocarmycin analogues with the linker arms of the invention.
    Type: Grant
    Filed: March 2, 2009
    Date of Patent: October 11, 2011
    Assignee: Medarex, Inc.
    Inventors: Howard P. Ng, Zhi-Hong Li, Danny P. C. McGee, Oliver L. Saunders, Guoxian Wu, David John King, Valeri Martichonok, Sharon Elaine Boyd, Thomas J. Lobl
  • Receptacle connector having reinforced bracket increasing overall rigidity
    Patent number: 8033866
    Abstract: A receptacle connector comprises an insulative housing having a base portion; a plurality of terminals retained in the insulative housing; a shielding shell assembled on the base portion of the insulative housing and defined a mating cavity. A reinforced bracket includes a main portion attached to a bottom of the shielding shell and a pair of mounting portions extending from two ends of the main portion. Therefore, overall rigidity of the receptacle connector may be increased.
    Type: Grant
    Filed: October 13, 2009
    Date of Patent: October 11, 2011
    Assignee: Hon Hai Precision Ind. Co., Ltd.
    Inventors: Yu-Hua Mao, Zhi-Hong Fang
  • Composition for Inhibiting Melanogenesis and Use Thereof
    Publication number: 20110212194
    Abstract: The present invention provides a Cinnamomum subavenium extract for inhibiting melanogenesis. The present invention also provides a composition for inhibiting melanogenesis including compounds inhibit tyrosinase activity.
    Type: Application
    Filed: August 2, 2010
    Publication date: September 1, 2011
    Applicant: KAOHSIUNG MEDICAL UNIVERSITY
    Inventors: Hui-Min Wang, Chung-Yi Chen, Zhi-Hong Wen
  • Low profile connector with combo solder tails
    Patent number: 7993161
    Abstract: A low profile connector for mounting on a PCB comprising: an insulative housing, a plurality of terminals, a shielding shell and an auxiliary member. Each terminal is provided with a contacting section and a solder portion extending beyond insulative housing for connecting with the PCB. The shielding shell defines a mating opening surrounding the contact portion, and the auxiliary member defines a main portion attached to a bottom surface of the shielding shell and at least one horizontal portion located at one end thereof for mounting on an upper surface of the PCB. The shielding shell further includes a vertical portion perpendicular to the horizontal portion for inserting a hole of the PCB, and the horizontal portion of the auxiliary member has a concavity for receiving the vertical portion which decreasing space that the connector located on the PCB.
    Type: Grant
    Filed: April 6, 2010
    Date of Patent: August 9, 2011
    Assignee: Hon Hai Precision Ind. Co., Ltd.
    Inventors: Yu-Hua Mao, Zhi-Hong Fang
  • S-TRIAZOLE ALPHA- MERCAPTOACETANILIDES AS INHIBITORS OF HIV REVERSE TRANSCRIPTASE
    Publication number: 20110190491
    Abstract: A series of S-triazolyl ?-mercaptoacetanilides having general structure (1) are provided, where Q is CO2H, CONR2, SO3H, or SO2NR2. The compounds inhibit several variants of the reverse transcriptase of HIV, and are useful in the treatment of HIV infections.
    Type: Application
    Filed: April 6, 2011
    Publication date: August 4, 2011
    Applicant: Ardea Biosciences, Inc.
    Inventors: Jean-Luc Girardet, Yung-Hyo Koh, Martha De La Rosa, Esmir Gunic, Zhi Hong, Stanley Lang, Woo-Hong Kim