Abstract: A series of S-triazolyl ?-mercaptoacetanilides having general structure (1) are provided, where Q is CO2H, CONR2, SO3H, or SO2NR2. The compounds inhibit several variants of the reverse transcriptase of HIV, and are useful in the treatment of HIV infections.

Abstract: A TFT array substrate which includes a plurality of pixels arranged in a matrix, has each pixel including sub-pixels in a 2×2 matrix. Two data lines are between neighboring columns of the sub-pixels and scan line is arranged between neighboring rows of the sub-pixels. The sub-pixels in same row can be electrically coupled to one scan line. The sub-pixels for the same color in one same column can be electrically coupled to the neighboring data line. The sub-pixels configured to display another same color in the same column can be electrically coupled to another neighboring same data line. Each two adjacent sub-pixels displaying a same color have opposite polarities.

Abstract: An Internet of things (IoT) controller may execute a first IoT application, associated with operating an IoT device, and a second IoT application associated with operating the IoT device. The IoT controller may load an IoT application program interface (API) associated with the first IoT application and the second IoT application, and may identify a first set of functions including a first function, associated with the first IoT application, and a second function associated with the second IoT application. The IoT controller may translate, based on the IoT API, the first set of functions to a second set of functions including a third function, associated with the first IoT application, and a fourth function associated with the second IoT application. The IoT controller may cause the IoT device to operate, based on the second set of functions, during the execution of the first IoT application and the second IoT application.

Abstract: A planar patch clamp device is disclosed, which can be used for culturing a neuron in the device so as to form a neuron network, and detecting an electrical property of the neuron that forms the neuron network. The planar patch clamp device includes a plurality of protrusions formed on a first surface, an extracellular matrix forming substance which is coated on the peripheries of a through hole, and electrode sections.

Abstract: The present Invention relates to Pharmaceutical compositions useful in the treatment or prevention or cure of viral infections, such as HCV infections, and diseases associated with such infections.

Abstract: A method of isolating at least one phenanthroindolizidine alkaloid, in particular with telomerase inhibitory activity, from Tylophora atrofolliculata is used to isolate and obtain for example about six to eight phenanthroindolizidine alkaloids, including at least four new phenanthroindolizidine alkaloids which have not been previously isolated. Experimental tests confirmed an exceptional telomerase inhibitory activity of the phenanthroindolizidine alkaloids isolated. A pharmaceutical composition includes at least one phenanthroindolizidine alkaloid and at least one pharmaceutical tolerable excipient. Still further, a method of treating a subject suffering from cancer includes administering at least one phenanthroindolizidine alkaloid isolated from Tylophora atrofolliculata. Also, a method of treating a subject suffering from cancer includes administering to the subject at least one phenanthroindolizidine alkaloid having certain formula.

Abstract: The present Invention relates to long acting pharmaceutical compositions useful in the treatment or prevention or cure of viral infections, such as HCV infections, and diseases associated with such infections.

Abstract: A method of isolating at least one phenanthroindolizidine alkaloid, in particular with HIF-1 inhibitory activity, from Tylophora atrofolliculata is used to isolate and obtain for example about 22 phenanthroindolizidine alkaloids, including at least 11 new phenanthroindolizidine alkaloids which have not been previously isolated. Experimental tests confirmed an exceptional HIF-1 inhibitory activity of the phenanthroindolizidine alkaloids isolated. A pharmaceutical composition includes at least one phenanthroindolizidine alkaloid and at least one pharmaceutical tolerable excipient. A method of treating a subject suffering from cancer includes administering at least one phenanthroindolizidine alkaloid isolated from Tylophora atrofolliculata. A method of treating a subject suffering from cancer includes administering at least one phenanthroindolizidine alkaloid to the subject.

Abstract: The present Invention relates to pharmaceutical compositions useful in the treatment or prevention or cure of viral infections, such as HCV infections, and diseases associated with such infections.

Abstract: The present invention relates to a method of treating or preventing the visual function loss in optic nerve in a subject after crush injury by using 4-(Phenylsulfanyl)butane-2-one (4-PSB-2). The present invention has the ability of enhancing the protection effect of RGCs, preserving the visual function in optic nerve after crush injury, recovering the visual function loss, attenuating apoptosis in optic nerve after injury, and inhibiting the inflammatory responses in optic nerves after ON injury.

Abstract: A method of isolating at least one phenanthroindolizidine alkaloid, in particular with HIF-1 inhibitory activity, from Tylophora atrofolliculata is used to isolate and obtain for example about 22 phenanthroindolizidine alkaloids, including at least 11 new phenanthroindolizidine alkaloids which have not been previously isolated. Experimental tests confirmed an exceptional HIF-1 inhibitory activity of the phenanthroindolizidine alkaloids isolated. A pharmaceutical composition includes at least one phenanthroindolizidine alkaloid and at least one pharmaceutical tolerable excipient. A method of treating a subject suffering from cancer includes administering at least one phenanthroindolizidine alkaloid isolated from Tylophora atrofolliculata. A method of treating a subject suffering from cancer includes administering at least one phenanthroindolizidine alkaloid to the subject.

Abstract: The present invention provides a method of isolating at least one ingredient with anti-viral efficacy from Baphicacanthus cusia. The ingredient can be an alkaloid, a triterpenoid, a lignan, a phenylethanoid, a sesquiterpene lactone, or a flavonoid. Two new alkaloids are produced, which have not been previously reported. Moreover, the method isolates 12 compounds which could not or have not been previously isolated. A pharmaceutical composition includes the at least one ingredient and at least one pharmaceutical tolerable excipient. A method of treating a subject suffering from a viral disease includes administering at least one ingredient isolated from Baphicacanthus cusia.

Abstract: The present invention provides a general four-port on-wafer high frequency de-embedding method. The method comprises: for each on-wafer de-embedding dummy, building a model considering the distributive nature of high frequency characteristics of the on-wafer de-embedding dummy; obtaining the intrinsic Y-parameter admittance matrix of said N on-wafer de-embedding dummies by calculation or simulation by using said models; and solving the equation set which the corresponding measurement and calculation or simulation data of said on-wafer de-embedding dummies satisfy for the elements of the related admittance matrices of the parasitic four-port network to be stripped in de-embedding and model parameters of models on which said calculation or simulation is based.

Abstract: This invention concerns N-(2-arylamino) aryl sulfonamides, which are inhibitors of MEK and are useful in treatment of cancer and other hyperproliferative diseases.

Abstract: A transformer holder assembled with a transformer and placed into a through hole of a circuit board is provided, which includes a bottom wall and an annular side wall surrounding and connected to the periphery of the bottom wall. The bottom wall and the annular side wall together form an accommodating groove for containing the transformer. The transformer holder extends outward along left and right lateral edges of the annular side wall to respectively form a first flange and a second flange, and the first flange and the second flange cover a gap between an inner edge of the through hole of the circuit board and the annular side wall of the transformer holder.

Abstract: The present invention relates to a method for modulating angiogenesis in a subject in need thereof, which comprises administering an effective amount of composition comprising excavatolide B and a pharmaceutically acceptable carrier to the subject.

Abstract: A power supply apparatus with a protection function includes a pulse width modulation control unit, a pulse width modulation detecting unit, a switch unit and a feedback circuit. The feedback circuit detects a bus voltage. When the feedback circuit detects that the bus voltage is greater than a predetermined voltage, the feedback circuit sends an informing signal to the pulse width modulation control unit. The pulse width modulation control unit adjusts a duty cycle of a pulse width modulation signal and sends the pulse width modulation signal to the pulse width modulation detecting unit. When the pulse width modulation detecting unit detects that the duty cycle of the pulse width modulation signal is less than a predetermined cycle, the pulse width modulation detecting unit turns off the switch unit to stop outputting power to avoid a reverse current phenomenon.

Abstract: The present invention relates to a method of identifying and preferably quantifying at least one sphingolipid, in particular the sphingolipid portion in wild-type Cordyceps or Cordyceps derivates. A further aspect relates to a method of identifying wild-type Cordyceps in a Cordyceps sample as well as for identifying Cordyceps derivates in a Cordyceps sample. The methods of the present invention, thus, allow for determining the quality and safety of Cordyceps products and for advantageously differentiating between wild-type Cordyceps and Cordyceps derivates via the ratio and/or presence of certain sphingolipids especially suitable as markers.

Abstract: A method of isolating at least one sphingolipid portion selected from a sphingoid base portion, a ceramide portion, a glycosphingolipid portion or a phosphosphingolipid portion from Cordyceps, in particular from wild-type Cordyceps, allows for obtaining sphingolipid portions having an increased amount of one of sphingoid bases, ceramides, glycosphingolipids or phosphosphingolipids. The sphingolipid portions isolated contained significant amounts of sphingolipids not reported so far, and possess exceptional immunosuppressive activities. A method of treating a subject suffering from an inflammatory disease like an autoimmune disease or an allergic disease includes administering sphingolipids isolated from Cordyceps, in particular from wild-type Cordyceps. A method of treating a subject suffering from an inflammatory disease includes administering certain sphingolipids to the subject.

Abstract: A TFT array substrate which includes a plurality of pixels arranged in a matrix, has each pixel including sub-pixels in a 2×2 matrix. Two data lines are between neighboring columns of the sub-pixels and scan line is arranged between neighboring rows of the sub-pixels. The sub-pixels in same row can be electrically coupled to one scan line. The sub-pixels for the same color in one same column can be electrically coupled to the neighboring data line. The sub-pixels configured to display another same color in the same column can be electrically coupled to another neighboring same data line. Each two adjacent sub-pixels displaying a same color have opposite polarities.