Abstract: The present disclosure relates to compositions and methods for treating Williams syndrome (WS), herein identified as a neurodevelopmental oligodendrocyte hypomyelination-associated disease, and to compositions and methods for treatment of other neurodevelopmental myelination abnormality diseases or disorders.

Abstract: Disclosed herein are methods for promoting neuronal outgrowth in a subject with a neuronal lesion in their CNS by administering effective amounts of a pro-regenerative OPN fragment, optionally with IGF1 and/or BDNF. A voltage gated potassium channel blocker can also be administered. Pharmaceutical compositions, devices for administration, and kits are also disclosed.

Abstract: The invention discloses an electric pressure cooker cover, comprising a steel cover, an exhaust valve component and a cover handle arranged on the steel cover, characterized in that, the electric pressure cooker cover is provided with a thermometer and pressure gauge component which is embedded in the cover handle, the thermometer and pressure gauge component comprises a dial arranged on the cover handle and a probe arranged under the dial, and the probe penetrates through the steel cover to extend into the cooker. By installing the thermometer and pressure gauge, the electric pressure cooker cover enables the user to directly and conveniently observe the temperature and pressure in the pressure cooker.

Abstract: The invention discloses a three-dimensional heating multifunctional cooker, comprising a cover component, an inner pot component, a housing component and a base component, the inner pot component comprises an inner pot, characterized in that, multiple heating components are arranged in the three-dimensional heating multifunctional cooker, the heating components comprise a first heating component arranged in the cover component, a second heating component surrounding the side wall of the inner pot and a third heating component arranged in the inner pot, and the heating components can be controlled separately. The three-dimensional heating multifunctional cooker of the invention is provided with multiple heating components, and thus it reduces the loss of heat from the side wall of the inner pot, which effectively increases the efficiency; it also realizes the three-dimensional heating for the food in the cooker, which increases the heating efficiency and reduces the energy consumption.

Abstract: A multipurpose cooker is composed of a base, a cooker body, cooker feet, a cooker cover, a cooker cover handle, cooker lugs, and a panel assembly and an operating mechanism on the cooker body; and an inner cooker is arranged in the cooker body, characterized in that, a food plate is arranged at the bottom of the inner cooker, a groove hole for placing heating members is opened in the middle of the food plate, and a heating tube as well as a seasoning box and a seasoning box cover outside the heating tube are arranged in the groove hole; and peripheral heating rings are also arranged in the side wall of the inner cooker.

Abstract: It discloses an electric pressure cooker with auxiliary heater, comprising pot cover subassembly, pot body subassembly, built-in heating plate subassembly and inner pot subassembly, characterized in that the said inner pot subassembly comprises inner pot, auxiliary heater and connector plug corresponding to auxiliary heater, the pot body is provided with connector socket corresponding to connector plug.

Abstract: Disclosed are compositions and methods for promoting survival of or axon regeneration in neurons by increasing mitochondrial motility in the neuron. Also disclosed are methods to treat neuronal injury and disease and disorders characterized by neuronal injury. Agents that increase Armcx1 activity, such as Armcx1 polypeptide or vectors comprising nucleic acid encoding Armcx1 polypeptide, are proposed for use in the methods. Pharmaceutical composition comprising the agents, and methods for identifying additional agents are also disclosed.

Abstract: A multipurpose cooker is composed of a base, a cooker body, cooker feet, a cooker cover, a cooker cover handle, cooker lugs, and a panel assembly and an operating mechanism on the cooker body; and an inner cooker is arranged in the cooker body, characterized in that, a food plate is arranged at the bottom of the inner cooker, a groove hole for placing heating members is opened in the middle of the food plate, and a heating tube as well as a seasoning box and a seasoning box cover outside the heating tube are arranged in the groove hole; and peripheral heating rings are also arranged in the side wall of the inner cooker.

Abstract: Disclosed herein is a method of promoting sustained survival, sustained regeneration, in a lesioned mature neuron, sustained compensatory outgrowth in a neuron, or combinations thereof. The method comprises contacting the lesioned mature neuron with an effective amount of an inhibitor of PTEN and an effective amount of an inhibitor of SOCS3 to thereby promote survival and/or regeneration and/or compensatory outgrowth of the neuron. Therapeutic methods of treatment of a subject with a neuronal lesion by administration of a therapeutically effective amount of an inhibitor of PTEN and a therapeutically effective amount of an inhibitor of SOCS3, are also disclosed, as are pharmaceutical compositions and devices for use in the methods.

Abstract: Disclosed herein is a method of promoting sustained survival, sustained regeneration, in a lesioned mature neuron, sustained compensatory outgrowth in a neuron, or combinations thereof. The method comprises contacting the lesioned mature neuron with an effective amount of an inhibitor of PTEN and an effective amount of an inhibitor of SOCS3 to thereby promote survival and/or regeneration and/or compensatory outgrowth of the neuron. Therapeutic methods of treatment of a subject with a neuronal lesion by administration of a therapeutically effective amount of an inhibitor of PTEN and a therapeutically effective amount of an inhibitor of SOCS3, are also disclosed, as are pharmaceutical compositions and devices for use in the methods.

Abstract: Disclosed are methods for promoting survival of, or axon regeneration in a lesioned mature central nervous system (CNS) by contacting the neuron with a therapeutically effective amount of an exogenous activator of protein translation. Detecting the resultant promotion of the survival of, or axon regeneration in the neuron may further be performed. The methods may be performed using an inhibitor of phosphatase and tensin homolog (PTEN). Pharmaceutical compositions and preloaded devices for use in the methods are also disclosed.

Abstract: Survival of, or axon regeneration in a lesioned mature central nervous system (CNS) neuron is promoted by (a) contacting the neuron with a therapeutically effective amount of an exogenous activator of protein translation; and (b) detecting the resultant promotion of the survival of, or axon regeneration in the neuron.

Abstract: It discloses an electric pressure cooker with auxiliary heater, comprising pot cover subassembly, pot body subassembly, built-in heating plate subassembly and inner pot subassembly, characterized in that the said inner pot subassembly comprises inner pot, auxiliary heater and connector plug corresponding to auxiliary heater, the pot body is provided with connector socket corresponding to connector plug.

Abstract: Disclosed herein is a method of promoting sustained survival, sustained regeneration, in a lesioned mature neuron, sustained compensatory outgrowth in a neuron, or combinations thereof. The method comprises contacting the lesioned mature neuron with an effective amount of an inhibitor of PTEN and an effective amount of an inhibitor of SOCS3 to thereby promote survival and/or regeneration and/or compensatory outgrowth of the neuron. Therapeutic methods of treatment of a subject with a neuronal lesion by administration of a therapeutically effective amount of an inhibitor of PTEN and a therapeutically effective amount of an inhibitor of SOCS3, are also disclosed, as are pharmaceutical compositions and devices for use in the methods.

Abstract: A cooking pot comprises a pot body, a control device, an electrical heating device, a thermostat and a temperature sensor, wherein the electrical heating device, thermostat and temperature sensor are provided in the pot body, and the control device is connected with the electrical heating device, thermostat and temperature sensor, characterized in that the said pot body is provided with an outer pot and an inner pot, the electrical heating device clings to or is close to the outer pot, the inner pot is provided inside the outer pot, and the external bottom surface of the inner port is in contact with the internal bottom surface of the outer pot.

Abstract: Disclosed herein is a method of promoting sustained survival, sustained regeneration, in a lesioned mature neuron, sustained compensatory outgrowth in a neuron, or combinations thereof. The method comprises contacting the lesioned mature neuron with an effective amount of an inhibitor of PTEN and an effective amount of an inhibitor of SOCS3 to thereby promote survival and/or regeneration and/or compensatory outgrowth of the neuron. Therapeutic methods of treatment of a subject with a neuronal lesion by administration of a therapeutically effective amount of an inhibitor of PTEN and a therapeutically effective amount of an inhibitor of SOCS3, are also disclosed, as are pharmaceutical compositions and devices for use in the methods.

Abstract: Disclosed herein is a method of promoting sustained survival, sustained regeneration, in a lesioned mature neuron, sustained compensatory outgrowth in a neuron, or combinations thereof. The method comprises contacting the lesioned mature neuron with an effective amount of an inhibitor of PTEN and an effective amount of an inhibitor of SOCS3 to thereby promote survival and/or regeneration and/or compensatory outgrowth of the neuron. Therapeutic methods of treatment of a subject with a neuronal lesion by administration of a therapeutically effective amount of an inhibitor of PTEN and a therapeutically effective amount of an inhibitor of SOCS3, are also disclosed, as are pharmaceutical compositions and devices for use in the methods.

Abstract: A pressure cooker cover comprises a cover (1) and a float valve (2), wherein a seal ring (7) is installed in the inner edge of the cover while hooks (8) are installed in the two side edges of the cover. A push-pull device (9) which can move the hooks back and forth is mounted in the ends of the hooks. The push-pull device comprises a rotating base (9-1) arranged in the middle portion of the cover, a rotating shaft (9-2) and a locking piece (9-3) which is coupled with the rotating shaft (9-2). Sliding chutes (9-31) are provided at the two sides of the locking piece. Guide columns (8-1) which are slidingly matched with the sliding chutes are set at two ends of the hooks (8).

Abstract: A pressure cooker cover comprises a cover (1) and a float valve (2), wherein a seal ring (7) is installed in the inner edge of the cover while hooks (8) are installed in the two side edges of the cover. A push-pull device (9) which can move the hooks back and forth is mounted in the ends of the hooks. The push-pull device comprises a rotating base (9-1) arranged in the middle portion of the cover, a rotating shaft (9-2) and a locking piece (9-3) which is coupled with the rotating shaft (9-2). Sliding chutes (9-31) are provided at the two sides of the locking piece. Guide columns (8-1) which are slidingly matched with the sliding chutes are set at two ends of the hooks (8).

Abstract: Disclosed herein is a method of promoting sustained survival, sustained regeneration, in a lesioned mature neuron, sustained compensatory outgrowth in a neuron, or combinations thereof. The method comprises contacting the lesioned mature neuron with an effective amount of an inhibitor of PTEN and an effective amount of an inhibitor of SOCS3 to thereby promote survival and/or regeneration and/or compensatory outgrowth of the neuron. Therapeutic methods of treatment of a subject with a neuronal lesion by administration of a therapeutically effective amount of an inhibitor of PTEN and a therapeutically effective amount of an inhibitor of SOCS3, are also disclosed, as are pharmaceutical compositions and devices for use in the methods.