Patents by Inventor Zhigang He

Zhigang He has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20140213609
    Abstract: Survival of, or axon regeneration in a lesioned mature central nervous system (CNS) neuron is promoted by (a) contacting the neuron with a therapeutically effective amount of an exogenous activator of protein translation; and (b) detecting the resultant promotion of the survival of, or axon regeneration in the neuron.
    Type: Application
    Filed: April 3, 2014
    Publication date: July 31, 2014
    Applicant: CHILDREN'S MEDICAL CENTER CORPORATION
    Inventors: Zhigang HE, Kevin PARK, Kai LIU, Yang HU
  • Patent number: 8728756
    Abstract: Survival of, or axon regeneration in a lesioned mature central nervous system (CNS) neuron is promoted by (a) contacting the neuron with a therapeutically effective amount of an exogenous activator of protein translation; and (b) detecting the resultant promotion of the survival of, or axon regeneration in the neuron.
    Type: Grant
    Filed: December 28, 2012
    Date of Patent: May 20, 2014
    Assignee: Children's Medical Center Corporation
    Inventors: Zhigang He, Kevin Park, Kai Liu, Yang Hu
  • Publication number: 20130255509
    Abstract: Disclosed is an electric pressure cooker with a removable flip cover comprising a cooker body (1) and cooker cover (2), wherein a supporting arm (3) is provided on the surface of the cooker cover (2), a positioning seat (5) corresponding to the supporting arm (3) is arranged at the edge of the cooker body (1), a positioning and supporting point (7) is provided on the positioning seat (5), and the lower part of the supporting arm (3) movably slips over and slidably contacts the positioning and supporting point (7). The electric pressure cooker has a simple structure and it is convenient to wash the flip cover without the need for special parts.
    Type: Application
    Filed: December 22, 2011
    Publication date: October 3, 2013
    Inventors: Zhigang He, Zhibin Huang
  • Publication number: 20130180986
    Abstract: The present invention discloses a pressure cooker cover which comprises a cover (1) and a float valve (2), wherein a seal ring (7) is installed in the inner edge of the cover while hooks (8) are installed in the two side edges of the cover. A push-pull device (9) which can move the hooks back and forth is mounted in the ends of the hooks. The push-pull device comprises a rotating base (9-1) arranged in the middle portion of the cover, a rotating shaft (9-2) and a locking piece (9-3) which is coupled with the rotating shaft (9-2). Sliding chutes (9-31) are provided at the two sides of the locking piece. Guide columns (8-1) which are slidingly matched with the sliding chutes are set at two ends of the hooks (8).
    Type: Application
    Filed: November 11, 2010
    Publication date: July 18, 2013
    Inventors: Zhigang He, Zhibin Huang
  • Patent number: 8367352
    Abstract: Survival of, or axon regeneration in a lesioned mature central nervous system (CNS) neuron is promoted by (a) contacting the neuron with a therapeutically effective amount of an exogenous activator of protein translation; and (b) detecting the resultant promotion of the survival of, or axon regeneration in the neuron.
    Type: Grant
    Filed: June 6, 2009
    Date of Patent: February 5, 2013
    Assignee: Children's Medical Center Corporation
    Inventors: Zhigang He, Kevin Park, Kai Liu, Yang Hu
  • Patent number: 8142782
    Abstract: Compositions and methods for promoting neural regeneration in a patient determined to have a lesion in a mature CNS neuron are disclosed. The method comprises the step of contacting the neuron with an EGFR inhibitor sufficient to promote regeneration of the neuron.
    Type: Grant
    Filed: February 18, 2009
    Date of Patent: March 27, 2012
    Assignee: Children's Medical Center Corporation
    Inventors: Zhigang He, Vuk Koprivica
  • Patent number: 7959901
    Abstract: Compositions and methods for promoting neural regeneration in a patient determined to have a lesion in a mature CNS neuron are disclosed. The method comprises the step of contacting the neuron with an EGFR inhibitor sufficient to promote regeneration of the neuron.
    Type: Grant
    Filed: February 6, 2008
    Date of Patent: June 14, 2011
    Assignee: Children's Medical Center Corporation
    Inventors: Zhigang He, Vuk Koprivica
  • Publication number: 20110124706
    Abstract: Regeneration of injured CNS neurons in a mammal in need thereof is promoted by delivering directly to the body of the injured CNS neurons, such as with an intracerebral or intraretinal cannula, an effective amount of a specific inhibitor of SOCS3.
    Type: Application
    Filed: November 25, 2009
    Publication date: May 26, 2011
    Inventors: Zhigang He, Patrice D. Smith, Fang Sun
  • Patent number: 7745151
    Abstract: Inhibitors of Nogo Receptor (NgR)-p75 binding are used to reduce NgR-p75 binding mediated axon growth inhibition. Mixtures of NgR and p75 are used in pharmaceutical screens to characterize agents as inhibiting binding of NgR to p75 and promoting axon regeneration.
    Type: Grant
    Filed: August 2, 2002
    Date of Patent: June 29, 2010
    Assignee: Children's Medical Center Corporation
    Inventors: Zhigang He, Kevin C. Wang, Jieun A. Kim
  • Patent number: 7718928
    Abstract: A multifunction safe electric pressure cooker includes a lid, an outer body, a warming container, a control panel, an inner tank, a sealant washer, a heating plate under the inner tank, and a control device. The control device comprises a control circuit, a pressure switch, and a temperature control device. The lid has a floating valve, a pressure discharging valve, and a safety valve. Between the heating plate and the warming container there is a spring device. Under the heating plate is a pole. The control device employs a sensor to determine whether the inner tank is placed in the cooker. Between the lid and the body sets a lid safety control switch that connected to the control circuit. The electric pressure cooker is more convenient and durable, can fry and sauté food, and includes multiple safety devices.
    Type: Grant
    Filed: December 15, 2006
    Date of Patent: May 18, 2010
    Inventors: Zhigang He, Zhibin Huang
  • Patent number: 7691590
    Abstract: Oligodendrocyte-myelin glycoprotein (OMgp)-specific binding agents are used to reduce OMgp-mediated axon growth inhibition. Mixtures of axons and OMgp and mixtures of Nogo receptor (NgR) and OMgp are used in pharmaceutical screens to characterize agents as inhibiting binding of NgR to OMgp and promoting axon regeneration.
    Type: Grant
    Filed: December 18, 2007
    Date of Patent: April 6, 2010
    Assignee: Children's Medical Center Corporation
    Inventors: Zhigang He, Kevin C. Wang, Vuk Koprivica, Jieun A. Kim
  • Publication number: 20090305333
    Abstract: Survival of, or axon regeneration in a lesioned mature central nervous system (CNS) neuron is promoted by (a) contacting the neuron with a therapeutically effective amount of an exogenous activator of protein translation; and (b) detecting the resultant promotion of the survival of, or axon regeneration in the neuron.
    Type: Application
    Filed: June 6, 2009
    Publication date: December 10, 2009
    Inventors: Zhigang He, Kevin Park, Kai Liu, Yang Hu
  • Patent number: 7625709
    Abstract: Inhibitors of Nogo Receptor (NgR)-p75 binding are used to reduce NgR-p75 binding mediated axon growth inhibition. Mixtures of NgR and p75 are used in pharmaceutical screens to characterize agents as inhibiting binding of NgR to p75 and promoting axon regeneration.
    Type: Grant
    Filed: December 27, 2005
    Date of Patent: December 1, 2009
    Assignee: Children's Medical Center Corporation
    Inventors: Zhigang He, Kevin C. Wang, Jieun A. Kim
  • Publication number: 20090220570
    Abstract: Regenerative growth of an adult mammalian central nervous system neuron axon subject to growth inhibition by endogenous, myelin growth repulsion factors is promoted by delivering to the axon a therapeutically effective amount of a specific inhibitor of protein kinase C, whereby regenerative growth of the axon is promoted and a resultant promotion of the regenerative growth of the axon is detected.
    Type: Application
    Filed: May 18, 2009
    Publication date: September 3, 2009
    Inventors: Zhigang He, Vuk Koprivica, Rajeev Sivasankanan
  • Publication number: 20090181420
    Abstract: Regeneration of a lesioned CNS axon of a mature neuron, determined to be subject to regeneration inhibition by Smad2/3 signaling, is promoted by contacting the neuron with an inhibitor of Smad2/3 signaling sufficient to promote regeneration of the axon.
    Type: Application
    Filed: March 13, 2009
    Publication date: July 16, 2009
    Inventors: Zhigang He, Fan Wang
  • Publication number: 20090148494
    Abstract: Compositions and methods for promoting neural regeneration in a patient determined to have a lesion in a mature CNS neuron are disclosed. The method comprises the step of contacting the neuron with an EGFR inhibitor sufficient to promote regeneration of the neuron.
    Type: Application
    Filed: February 18, 2009
    Publication date: June 11, 2009
    Inventors: Zhigang He, Vuk Koprivica
  • Patent number: 7524640
    Abstract: Regeneration of a lesioned CNS axon of a mature neuron, determined to be subject to regeneration inhibition by Smad2/3 signaling, is promoted by contacting the neuron with an inhibitor of Smad2/3 signaling sufficient to promote regeneration of the axon.
    Type: Grant
    Filed: August 6, 2006
    Date of Patent: April 28, 2009
    Assignees: Children's Medical Center Corporation, Duke University
    Inventors: Zhigang He, Fan Wang
  • Patent number: 7449442
    Abstract: Compositions and methods for promoting neural regeneration in a patient determined to have a lesion in a mature CNS neuron are disclosed. The method comprises the step of contacting the neuron with an EGFR inhibitor sufficient to promote regeneration of the neuron.
    Type: Grant
    Filed: July 12, 2005
    Date of Patent: November 11, 2008
    Assignee: Children's Medical Center Corporation
    Inventors: Zhigang He, Vuk Koprivica
  • Publication number: 20080188411
    Abstract: Oligodendrocyte-myelin glycoprotein (OMgp)-specific binding agents are used to reduce OMgp-mediated axon growth inhibition. Mixtures of axons and OMgp and mixtures of Nogo receptor (NgR) and OMgp are used in pharmaceutical screens to characterize agents as inhibiting binding of NgR to OMgp and promoting axon regeneration.
    Type: Application
    Filed: December 18, 2007
    Publication date: August 7, 2008
    Inventors: Zhigang He, Kevin C. Wang, Vuk Koprivica, Jieun A. Kim
  • Publication number: 20080145314
    Abstract: Compositions and methods for promoting neural regeneration in a patient determined to have a lesion in a mature CNS neuron are disclosed. The method comprises the step of contacting the neuron with an EGFR inhibitor sufficient to promote regeneration of the neuron.
    Type: Application
    Filed: February 6, 2008
    Publication date: June 19, 2008
    Inventors: Zhigang He, Vuk Koprivica