Abstract: The present application provides the compounds of formula (J), or pharmaceutically acceptable salts, isomers, tautomer, or a mixture thereof, wherein n, W, A?, B?, R1, R2, and R3 are described herein. The compounds are inhibitors to the activities of phosphatidylinositol 3-kinase (PI3K) and are useful for treating conditions mediated by one or more PI3K isoforms. The present application further provides pharmaceutical compositions that include a compound of formula (I), or pharmaceutically acceptable salts, isomers, tautomer, or mixture thereof, and methods of using these compounds and compositions for treating conditions mediated by one or more PI3K isoforms.

Abstract: Compounds having the following formula (I) and methods of their use and preparation are disclosed:

Abstract: Methods and devices for dynamic VSIM provisioning on a multi-SIM wireless device having a first SIM as a Universal Integrated Circuit Card (UICC) and a virtual SIM (VSIM). A provisioning server may receive updated information from the wireless device, and based at least partially on the received information, determine whether the SIM profile on the VSIM of the wireless device should be changed. To change the SIM profile, the provisioning server may determine whether remote credential management procedures are enabled. If so, the provisioning server may select a new SIM profile from a plurality of SIM profiles, and provision the new SIM profile in the VSIM using remote credential management procedures. If remote credential management procedures are unavailable, the provisioning server may select a remote SIM from a plurality of remote SIMs associated with the provisioning server, and run the remote SIM to execute authentication processes for the wireless device.

Abstract: The present disclosure relates to compounds that are Syk inhibitors and to their use in the treatment of various disease states, including cancer and inflammatory conditions. In particular embodiments, the structure of the compounds is given by Formula I wherein X1, X2, X3, R2, R3, R4, R5, and Y are as described herein. The present disclosure further provides pharmaceutical compositions that include a compound of Formula I, or pharmaceutically acceptable salts thereof, and methods of using these compounds and compositions to treat conditions mediated by Syk.

Abstract: A method for inter-standard network roaming is provided. Upon roaming into a visited network, an access terminal may send a location update message that includes its current mobile subscriber identity. A roaming gateway receives the update message and uses the current mobile subscriber identity to determine whether the access terminal should be assigned a new mobile subscriber identity for operation in the visited network. If the current mobile subscriber identity indicates that the access terminal is not using a preferred roaming sponsor for the visited network, then the roaming gateway generates or selects a new mobile subscriber identity associated with the preferred roaming sponsor. The new mobile subscriber identity is securely transmitted to the access terminal which uses it for communications over the visited network thereafter.

Abstract: A method and apparatus for enabling backward compatibility in open market handsets (OMH) is provided. The method may include determining a type of an identity module based on one or more internal parameters of the identity module, and obtaining one or more credentials based at least in part on the determined the type identity module.

Abstract: Techniques for supporting location services with roaming are described. A method of supporting location services (LCS) for a mobile station roaming from a home network and communicating with a visited network includes receiving a domain name system (DNS) query at a DNS of the home network from a packet data serving node (PDSN) of the home network. The method also includes sending to the mobile station from the DNS of the home network an address of a serving position determining entity (S-PDE) in the visited network.

Abstract: Methods and apparatus for determining a charge for a communication with one or more devices may include identifying a communication from a first device to a second device. The methods and apparatus may further include determining if the first device has a relationship with the second device by identifying another communication between the first device and the second device prior to the time of the communication, and determining a charge amount based upon the determining.

Abstract: Techniques for supporting location services (LCS) with roaming are described. A method of supporting LCS in a network comprising a Secure User Plane Location (SUPL) enabled terminal (SET), a home SUPL location center (H-SLC), and a serving SUPL location center (S-SLC) includes receiving, at the H-SLC, a location request message for a location of the SET, where the location request message comprises an indication of a network location of the SET. The method includes sending, to the S-SLC in response to the location request message, a roaming request message. The method includes receiving, from the S-SLC in response to the roaming request message, a location report message comprising a position of the network location. The method also includes sending a reporting message comprising the position of the network location of the SET as the location of the SET.

Abstract: Methods and apparatuses are provided for facilitating authentication of access terminal identities and for recording a usage relationship between a valid access terminal identity and a user identity. An access terminal and a validation server are both provisioned with corresponding validation keys. The access terminal may determine that a user identity is not recorded for use with the access terminal, and may send a report message to report a usage relationship between the access terminal identity and the user identity, where the report message is signed with a signature based on the validation key. The validation server authenticates the signature using the validation key in the validation server. The validation server may record the usage relationship between the authenticated access terminal identity and the user identity in a database, which database records may be employed to determine whether an access terminal requesting network access is authorized or unauthorized.

Abstract: Techniques for supporting location services (LCS) with roaming are described. A method of supporting LCS in a network comprising a Secure User Plane Location (SUPL) enabled terminal (SET), a home SUPL location center (H-SLC), and a serving SUPL location center (S-SLC) includes receiving, at the H-SLC, a location request message for a location of the SET, where the location request message comprises an indication of a network location of the SET. The method includes sending, to the S-SLC in response to the location request message, a roaming request message. The method includes receiving, from the S-SLC in response to the roaming request message, a location report message comprising a position of the network location. The method also includes sending a reporting message comprising the position of the network location of the SET as the location of the SET.

Abstract: Techniques for supporting location services with roaming are described. A method of supporting location services (LCS) for a mobile station roaming from a home network and communicating with a visited network includes receiving a domain name system (DNS) query at a DNS of the home network from a packet data serving node (PDSN) of the home network. The method also includes sending to the mobile station from the DNS of the home network an address of a serving position determining entity (S-PDE) in the visited network.

Abstract: Techniques for supporting location services with roaming are described. A mobile station interacts with a home mobile positioning center (H-MPC) in a home network for location services even when roaming. The mobile station communicates with a visited network for a data session and receives a request for its location. The mobile station sends first information (e.g., SID and NID) indicative of its current network location to the H-MPC. The H-MPC determines a serving mobile positioning center (S-MPC) in the visited network based on the first information. The S-MPC determines a serving position determining entity (S-PDE) in the visited network based on the first information. Depending on the selected positioning method, the H-MPC may receive an S-PDE address or a position estimate of the mobile station from the S-MPC and may forward this information to mobile station. The mobile station may communicate with the S-PDE for positioning using the S-PDE address.

Abstract: The present application includes novel inhibitors of HCV, compositions containing such compounds, therapeutic methods that include the administration of such compounds.

Abstract: A method and apparatus for enabling backward compatibility in open market handsets (OMH) is provided. The method may include determining a type of an identity module based on one or more internal parameters of the identity module, and obtaining one or more credentials based at least in part on the determined the type identity module.

Abstract: A system and method of incrementally updating a preferred roaming list (PRL) are disclosed. The systems and methods include modifying a removable user identity module (RUIM) card on the mobile device to accept data structures that include incremental update information for a PRL. The systems and methods also include modifying a removable user identity module (RUIM) card on the mobile device to execute operators that allow for a PRL to be incrementally updated.

Abstract: The invention is related to anti-viral compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.

Abstract: Methods and apparatus for determining a charge for a communication with one or more devices may include identifying a communication from a first device to a second device. The methods and apparatus may further include determining if the first device has a relationship with the second device by identifying another communication between the first device and the second device prior to the time of the communication, and determining a charge amount based upon the determining.

Abstract: A method for inter-standard network roaming is provided. Upon roaming into a visited network, an access terminal may send a location update message that includes its current mobile subscriber identity. A roaming gateway receives the update message and uses the current mobile subscriber identity to determine whether the access terminal should be assigned a new mobile subscriber identity for operation in the visited network. If the current mobile subscriber identity indicates that the access terminal is not using a preferred roaming sponsor for the visited network, then the roaming gateway generates or selects a new mobile subscriber identity associated with the preferred roaming sponsor. The new mobile subscriber identity is securely transmitted to the access terminal which uses it for communications over the visited network thereafter.

Abstract: The invention is related to anti-viral compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.