Patents by Inventor Zhiwen Zhang

Zhiwen Zhang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods and composition for the production of orthogonal tRNA-aminoacyl tRNA synthetase pairs
    Publication number: 20090053791
    Abstract: This invention provides compositions and methods for generating components of protein biosynthetic machinery including orthogonal tRNAs, orthogonal aminoacyl-tRNA synthetases, and orthogonal pairs of tRNAs/synthetases. Methods for identifying orthogonal pairs are also provided. These components can be used to incorporate unnatural amino acids into proteins in vivo.
    Type: Application
    Filed: October 26, 2007
    Publication date: February 26, 2009
    Inventors: Peter Schultz, Lei Wang, John Christopher Anderson, Jason W. Chin, David R. Liu, Thomas J. Magliery, Eric L. Meggers, Ryan Aaron Mehl, Miro Pastrnak, Stephen William Santoro, Zhiwen Zhang
  • Site-specific incorporation of redox active amino acids into proteins
    Patent number: 7494796
    Abstract: Compositions and methods of producing components of protein biosynthetic machinery that include orthogonal tRNAs, orthogonal aminoacyl-tRNA synthetases, and orthogonal pairs of tRNAs/synthetases, which incorporate redox active amino acids into proteins are provided. Methods for identifying these orthogonal pairs are also provided along with methods of producing proteins with redox active amino acids using these orthogonal pairs.
    Type: Grant
    Filed: October 13, 2004
    Date of Patent: February 24, 2009
    Assignee: The Scripps Research Institute
    Inventors: Lital Alfonta, Peter G. Schultz, Zhiwen Zhang
  • In vivo incorporation of unnatural amino acids
    Publication number: 20080261311
    Abstract: The invention provides methods and compositions for in vivo incorporation of unnatural amino acids. Also provided are compositions including proteins with unnatural amino acids.
    Type: Application
    Filed: October 26, 2007
    Publication date: October 23, 2008
    Inventors: Peter Schultz, Lei Wang, John Christopher Anderson, Jason William Chin, David R. Liu, Thomas J. Magliery, Eric L. Meggers, Ryan A. Mehl, Miro Pastrnak, Stephen William Santoro, Zhiwen Zhang
  • In vivo site-sepecific incorporation of N-acetyl-galactosamine amino acids in eubacteria
    Publication number: 20080241903
    Abstract: Methods and compositions for making glycoproteins, both in vitro and in vivo, are provided. One method involves incorporating an unnatural amino acid having a N-acetylgalactosamine moiety into a protein; optionally, the N-acetylgalactosamine-containing unnatural amino acid can be further modified with additional sugars.
    Type: Application
    Filed: April 8, 2008
    Publication date: October 2, 2008
    Applicant: The Scripps Research Institute
    Inventors: Peter G. Schultz, Sarah R. Hanson, Ran Xu, Zhiwen Zhang, Chi-Huey Wong
  • In vivo incorporation of unnatural amino acids
    Publication number: 20080227152
    Abstract: The invention provides methods and compositions for in vivo incorporation of unnatural amino acids. Also provided are compositions including proteins with unnatural amino acids.
    Type: Application
    Filed: October 26, 2007
    Publication date: September 18, 2008
    Applicants: The Scripps Research Institute, The Regents of the University of California
    Inventors: Peter Schultz, Lei Wang, John Christopher Anderson, Jason William Chin, David R. Liu, Thomas J. Magliery, Eric L. Meggers, Ryan A. Mehl, Miro Pastrnak, Stephen William Santoro, Zhiwen Zhang
  • Glycoprotein synthesis
    Publication number: 20080213828
    Abstract: Methods for making glycoproteins, both in vitro and in vivo, are provided. One method involves incorporating an unnatural amino acid into a protein and attaching one or more saccharide moieties to the unnatural amino acid. Another method involves incorporating an unnatural amino acid that includes a saccharide moiety into a protein. Proteins made by both methods can be further modified with additional sugars.
    Type: Application
    Filed: October 26, 2007
    Publication date: September 4, 2008
    Applicant: The Scripps Research Institute
    Inventors: Peter G. Schultz, Lei Wang, Zhiwen Zhang
  • In vivo incorporation of unnatural amino acids
    Publication number: 20080167243
    Abstract: The invention provides methods and compositions for in vivo incorporation of unnatural amino acids. Also provided are compositions including proteins with unnatural amino acids.
    Type: Application
    Filed: October 26, 2007
    Publication date: July 10, 2008
    Inventors: Peter Schultz, Lei Wang, John Christopher Anderson, Jason William Chin, David R. Liu, Thomas J. Magliery, Eric L. Meggers, Ryan Aaron Mehl, Miro Pastrnak, Stephen William Santoro, Zhiwen Zhang
  • In vivo incorporation of unnatural amino acids
    Publication number: 20080166783
    Abstract: The invention provides methods and compositions for in vivo incorporation of unnatural amino acids. Also provided are compositions including proteins with unnatural amino acids.
    Type: Application
    Filed: May 4, 2007
    Publication date: July 10, 2008
    Applicant: The Scripps Research Institute and The Regents of the University of California
    Inventors: Peter Schultz, Lei Wang, John Christopher Anderson, Jason William Chin, David R. Liu, Thomas J. Magliery, Eric L. Meggers, Ryan A. Mehl, Miro Pastrnak, Stephen William Santoro, Zhiwen Zhang
  • In vivo site-specific incorporation of N-acetyl-galactosamine amino acids in eubacteria
    Patent number: 7378263
    Abstract: Methods and compositions for making glycoproteins, both in vitro and in vivo, are provided. One method involves incorporating an unnatural amino acid having a N-acetylgalactosamine moiety into a protein; optionally, the N-acetylgalactosamine-containing unnatural amino acid can be further modified with additional sugars.
    Type: Grant
    Filed: October 20, 2005
    Date of Patent: May 27, 2008
    Assignee: The Scripps Research Institute
    Inventors: Peter G. Schultz, Sarah R. Hanson, Ran Xu, Zhiwen Zhang, Chi-Heuy Wong
  • In vivo incorporation of unnatural amino acids
    Patent number: 7368275
    Abstract: The invention provides methods and compositions for in vivo incorporation of unnatural amino acids. Also provided are compositions including proteins with unnatural amino acids.
    Type: Grant
    Filed: October 18, 2005
    Date of Patent: May 6, 2008
    Assignees: The Scripps Research Institute, The Regents of the University of California
    Inventors: Peter Schultz, Lei Wang, John Christopher Anderson, Jason W. Chin, David R. Liu, Thomas J. Magliery, Eric Meggers, Ryan Aaron Mehl, Miro Pastrnak, Steven William Santoro, Zhiwen Zhang
  • Methods and composition for the production of orthogonal tRNA-aminoacyltRNA synthetase pairs
    Patent number: 7354761
    Abstract: This invention provides compositions and methods for generating components of protein biosynthetic machinery including orthogonal tRNAs, orthogonal aminoacyl-tRNA synthetases, and orthogonal pairs of tRNAs/synthetases. Methods for identifying orthogonal pairs are also provided. These components can be used to incorporate unnatural amino acids into proteins in vivo.
    Type: Grant
    Filed: October 18, 2005
    Date of Patent: April 8, 2008
    Assignees: The Scripps Research Institute, The Regents of the University of California
    Inventors: Peter G. Schultz, Lei Wang, John Christopher Anderson, Jason Chin, David R. Liu, Thomas J. Magliery, Eric L. Meggers, Ryan Aaron Mehl, Miro Pastrnak, Steven William Santoro, Zhiwen Zhang
  • In Vivo Site-Specific Incorporation of N-Acetyl-Galactosamine Amino Acids in Eubacteria
    Publication number: 20080064059
    Abstract: Methods and compositions for making glycoproteins, both in vitro and in vivo, are provided. One method involves incorporating an unnatural amino acid having a N-acetylgalactosamine moiety into a protein; optionally, the N-acetylgalactosamine-containing unnatural amino acid can be further modified with additional sugars.
    Type: Application
    Filed: October 20, 2005
    Publication date: March 13, 2008
    Inventors: Peter Schultz, Sarah Hanson, Ran Xu, Zhiwen Zhang, Chi-Huey Wong
  • Glycoprotein synthesis
    Patent number: 7262040
    Abstract: Methods for making glycoproteins, both in vitro and in vivo, are provided. One method involves incorporating an unnatural amino acid into a protein and attaching one or more saccharide moieties to the unnatural amino acid. Another method involves incorporating an unnatural amino acid that includes a saccharide moiety into a protein. Proteins made by both methods can be further modified with additional sugars.
    Type: Grant
    Filed: March 29, 2005
    Date of Patent: August 28, 2007
    Assignee: The Scripps Research Institute
    Inventors: Peter G. Schultz, Lei Wang, Zhiwen Zhang
  • Glycoprotein synthesis
    Publication number: 20070184517
    Abstract: Methods for making glycoproteins, both in vitro and in vivo, are provided. One method involves incorporating an unnatural amino acid into a protein and attaching one or more saccharide moieties to the unnatural amino acid. Another method involves incorporating an unnatural amino acid that includes a saccharide moiety into a protein. Proteins made by both methods can be further modified with additional sugars.
    Type: Application
    Filed: September 12, 2006
    Publication date: August 9, 2007
    Applicant: THE SCRIPPS RESEARCH INSTITUTE
    Inventors: Peter Schultz, Lei Wang, Zhiwen Zhang
  • Glycoprotein synthesis
    Publication number: 20070172915
    Abstract: Methods for making glycoproteins, both in vitro and in vivo, are provided. One method involves incorporating an unnatural amino acid into a protein and attaching one or more saccharide moieties to the unnatural amino acid. Another method involves incorporating an unnatural amino acid that includes a saccharide moiety into a protein. Proteins made by both methods can be further modified with additional sugars.
    Type: Application
    Filed: October 11, 2006
    Publication date: July 26, 2007
    Applicant: The Scripps Research Institute
    Inventors: Peter Schultz, Lei Wang, Zhiwen Zhang
  • Glycoprotein synthesis
    Patent number: 7238510
    Abstract: Methods for making glycoproteins, both in vitro and in vivo, are provided. One method involves incorporating an unnatural amino acid into a protein and attaching one or more saccharide moieties to the unnatural amino acid. Another method involves incorporating an unnatural amino acid that includes a saccharide moiety into a protein. Proteins made by both methods can be further modified with additional sugars.
    Type: Grant
    Filed: December 14, 2004
    Date of Patent: July 3, 2007
    Assignee: The Scripps Research Institute
    Inventors: Peter G. Schultz, Lei Wang, Zhiwen Zhang
  • In vivo incorporation of unnatural amino acids
    Publication number: 20070117184
    Abstract: The invention provides methods and compositions for in vivo incorporation of unnatural amino acids. Also provided are compositions including proteins with unnatural amino acids.
    Type: Application
    Filed: October 18, 2006
    Publication date: May 24, 2007
    Inventors: Peter Schultz, Lei Wang, John Anderson, Jason Chin, David Liu, Thomas Magliery, Eric Meggers, Ryan Mehl, Miro Pastrnak, Stephen Santoro, Zhiwen Zhang
  • Selective incorporation of 5-hydroxytryptophan into proteins in mammalian cells
    Publication number: 20070111193
    Abstract: This invention provides methods and compositions for incorporation of an unnatural amino acid into a peptide using an orthogonal aminoacyl tRNA synthetase/tRNA pair. In particular, an orthogonal pair is provided to incorporate 5-hydroxy-L-tryptophan in a position encoded by an opal mutation.
    Type: Application
    Filed: December 16, 2004
    Publication date: May 17, 2007
    Inventors: Zhiwen Zhang, Lital Alfonta, Peter Schultz
  • Glycoprotein synthesis
    Patent number: 7217809
    Abstract: Methods for making glycoproteins, both in vitro and in vivo, are provided. One method involves incorporating an unnatural amino acid into a protein and attaching one or more saccharide moieties to the unnatural amino acid. Another method involves incorporating an unnatural amino acid that includes a saccharide moiety into a protein. Proteins made by both methods can be further modified with additional sugars.
    Type: Grant
    Filed: March 29, 2005
    Date of Patent: May 15, 2007
    Assignee: The Scripps Research Institute
    Inventors: Peter G. Schultz, Lei Wang, Zhiwen Zhang
  • Glycoprotein synthesis
    Patent number: 7199222
    Abstract: Methods for making glycoproteins, both in vitro and in vivo, are provided. One method involves incorporating an unnatural amino acid into a protein and attaching one or more saccharide moieties to the unnatural amino acid. Another method involves incorporating an unnatural amino acid that includes a saccharide moiety into a protein. Proteins made by both methods can be further modified with additional sugars.
    Type: Grant
    Filed: March 29, 2005
    Date of Patent: April 3, 2007
    Assignee: The Scripps Research Institute
    Inventors: Peter G. Shultz, Lei Wang, Zhiwen Zhang