Patents by Inventor Zhiwen Zhang

Zhiwen Zhang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Glycoprotein synthesis
    Patent number: 7183082
    Abstract: Methods for making glycoproteins, both in vitro and in vivo, are provided. One method involves incorporating an unnatural amino acid into a protein and attaching one or more saccharide moieties to the unnatural amino acid. Another method involves incorporating an unnatural amino acid that includes a saccharide moiety into a protein. Proteins made by both methods can be further modified with additional sugars.
    Type: Grant
    Filed: March 29, 2005
    Date of Patent: February 27, 2007
    Assignee: The Scripps Research Institute
    Inventors: Peter G. Schultz, Lei Wang, Zhiwen Zhang
  • Site-specific incorporation of redox active amino acids into proteins
    Publication number: 20070009990
    Abstract: Compositions and methods of producing components of protein biosynthetic machinery that include orthogonal tRNAs, orthogonal aminoacyl-tRNA synthetases, and orthogonal pairs of tRNAs/synthetases, which incorporate redox active amino acids into proteins are provided. Methods for identifying these orthogonal pairs are also provided along with methods of producing proteins with redox active amino acids using these orthogonal pairs.
    Type: Application
    Filed: October 13, 2004
    Publication date: January 11, 2007
    Inventors: Lital Alfonta, Peter Schultz, Zhiwen Zhang
  • Glycoprotein synthesis
    Patent number: 7129333
    Abstract: Methods for making glycoproteins, both in vitro and in vivo, are provided. One method involves incorporating an unnatural amino acid into a protein and attaching one or more saccharide moieties to the unnatural amino acid. Another method involves incorporating an unnatural amino acid that includes a saccharide moiety into a protein. Proteins made by both methods can be further modified with additional sugars.
    Type: Grant
    Filed: March 29, 2005
    Date of Patent: October 31, 2006
    Assignee: The Scripps Research Institute
    Inventors: Peter G. Schultz, Lei Wang, Zhiwen Zhang
  • In vivo incorporation of unnatural amino acids
    Publication number: 20060233744
    Abstract: The invention provides methods and compositions for in vivo incorporation of unnatural amino acids. Also provided are compositions including proteins with unnatural amino acids.
    Type: Application
    Filed: October 18, 2005
    Publication date: October 19, 2006
    Inventors: Peter Shultz, Lei Wang, John Anderson, Jason Chin, David Liu, Thomas Magliery, Eric Meggers, Ryan Mehl, Miro Pastmark, Steven Santoro, Zhiwen Zhang
  • Methods and composition for the production of orthogonal tRNA-aminoacyltRNA synthetase pairs
    Publication number: 20060234367
    Abstract: This invention provides compositions and methods for generating components of protein biosynthetic machinery including orthogonal tRNAs, orthogonal aminoacyl-tRNA synthetases, and orthogonal pairs of tRNAs/synthetases. Methods for identifying orthogonal pairs are also provided. These components can be used to incorporate unnatural amino acids into proteins in vivo.
    Type: Application
    Filed: October 18, 2005
    Publication date: October 19, 2006
    Inventors: Peter Schultz, Lei Wang, John Anderson, Jason Chin, David Liu, Thomas Magliery, Eric Meggers, Ryan Mehl, Miro Pastrnak, Stephen Santoro, Zhiwen Zhang
  • Methods and compositions for the production of orthogonal tRNA-aminoacyl tRNA synthetase pairs
    Patent number: 7083970
    Abstract: This invention provides compositions and methods for generating components of protein biosynthetic machinery including orthogonal tRNAs, orthogonal aminoacyl-tRNA synthetases, and orthogonal pairs of tRNAs/synthetases. Methods for identifying orthogonal pairs are also provided. These components can be used to incorporate unnatural amino acids into proteins in vivo.
    Type: Grant
    Filed: April 19, 2002
    Date of Patent: August 1, 2006
    Assignees: The Scripps Research Institute, The Regents of the University of California
    Inventors: Peter Schultz, Lei Wang, John Christopher Anderson, Jason Chin, David R. Liu, Thomas J. Magliery, Eric L. Meggers, Ryan Aaron Mehl, Miro Pastrnak, Stephen William Santoro, Zhiwen Zhang
  • In vivo site-specific incorporation of N-acetyl-galactosamine amino acids in eubacteria
    Publication number: 20060110796
    Abstract: Methods and compositions for making glycoproteins, both in vitro and in vivo, are provided. One method involves incorporating an unnatural amino acid having a N-acetylgalactosamine moiety into a protein; optionally, the N-acetylgalactosamine-containing unnatural amino acid can be further modified with additional sugars.
    Type: Application
    Filed: October 20, 2005
    Publication date: May 25, 2006
    Applicant: The Scripps Research Institute
    Inventors: Peter Schultz, Sarah Hanson, Ran Xu, Zhiwen Zhang, Chi-Huey Wong
  • In vivo incorporation of unnatural amino acids
    Patent number: 7045337
    Abstract: The invention provides methods and compositions for in vivo incorporation of unnatural amino acids. Also provided are compositions including proteins with unnatural amino acids.
    Type: Grant
    Filed: April 19, 2002
    Date of Patent: May 16, 2006
    Assignees: The Scripps Research Institute, The Regents of the University of California
    Inventors: Peter Schultz, Lei Wang, John Christopher Anderson, Jason William Chin, David R. Liu, Thomas J. Magliery, Eric L. Meggers, Ryan A. Mehl, Miro Pastrnak, Steven William Santoro, Zhiwen Zhang
  • Methods and composition for the production of orthogonal tRNA-aminoacyltRNA synthetase pairs
    Publication number: 20060063244
    Abstract: This invention provides compositions and methods for generating components of protein biosynthetic machinery including orthogonal tRNAs, orthogonal aminoacyl-tRNA synthetases, and orthogonal pairs of tRNAs/synthetases. Methods for identifying orthogonal pairs are also provided. These components can be used to incorporate unnatural amino acids into proteins in vivo.
    Type: Application
    Filed: December 1, 2004
    Publication date: March 23, 2006
    Applicant: The Scripps Research Institute
    Inventors: Peter Schultz, Lei Wang, John Anderson, Jason Chin, David Liu, Thomas Magliery, Eric Meggers, Ryan Mehl, Miro Pastrnak, Stephen Santoro, Zhiwen Zhang
  • Glycoprotein synthesis
    Publication number: 20050266526
    Abstract: Methods for making glycoproteins, both in vitro and in vivo, are provided. One method involves incorporating an unnatural amino acid into a protein and attaching one or more saccharide moieties to the unnatural amino acid. Another method involves incorporating an unnatural amino acid that includes a saccharide moiety into a protein. Proteins made by both methods can be further modified with additional sugars.
    Type: Application
    Filed: December 14, 2004
    Publication date: December 1, 2005
    Applicant: The Scripps Research Institute
    Inventors: Peter Schultz, Lei Wang, Zhiwen Zhang
  • In vivo incorporation of unnatural amino acids
    Publication number: 20050250183
    Abstract: The invention provides methods and compositions for in vivo incorporation of unnatural amino acids. Also provided are compositions including proteins with unnatural amino acids.
    Type: Application
    Filed: December 17, 2004
    Publication date: November 10, 2005
    Applicant: The Scripps Research Institute
    Inventors: Peter Schultz, Lei Wang, John Anderson, Jason Chin, David Liu, Thomas Magliery, Eric Meggers, Ryan Mehl, Miro Pastrnak, Stephen Santoro, Zhiwen Zhang
  • Glycoprotein synthesis
    Publication number: 20050233412
    Abstract: Methods for making glycoproteins, both in vitro and in vivo, are provided. One method involves incorporating an unnatural amino acid into a protein and attaching one or more saccharide moieties to the unnatural amino acid. Another method involves incorporating an unnatural amino acid that includes a saccharide moiety into a protein. Proteins made by both methods can be further modified with additional sugars.
    Type: Application
    Filed: March 29, 2005
    Publication date: October 20, 2005
    Applicant: The Scripps Research Institute
    Inventors: Peter Schultz, Lei Wang, Zhiwen Zhang
  • Site-specific incorporation of redox active amino acids into proteins
    Publication number: 20050227318
    Abstract: Compositions and methods of producing components of protein biosynthetic machinery that include orthogonal tRNAs, orthogonal aminoacyl-tRNA synthetases, and orthogonal pairs of tRNAs/synthetases, which incorporate redox active amino acids into proteins are provided. Methods for identifying these orthogonal pairs are also provided along with methods of producing proteins with redox active amino acids using these orthogonal pairs.
    Type: Application
    Filed: October 13, 2004
    Publication date: October 13, 2005
    Applicant: The Scripps Research Institute
    Inventors: Lital Alfonta, Peter Schultz, Zhiwen Zhang
  • Glycoprotein synthesis
    Publication number: 20050209133
    Abstract: Methods for making glycoproteins, both in vitro and in vivo, are provided. One method involves incorporating an unnatural amino acid into a protein and attaching one or more saccharide moieties to the unnatural amino acid. Another method involves incorporating an unnatural amino acid that includes a saccharide moiety into a protein. Proteins made by both methods can be further modified with additional sugars.
    Type: Application
    Filed: March 29, 2005
    Publication date: September 22, 2005
    Applicant: The Scripps Research Institute
    Inventors: Peter Schultz, Lei Wang, Zhiwen Zhang
  • Methods and composition for the production of orthogonal tRNA-aminoacyltRNA synthetase pairs
    Publication number: 20050208536
    Abstract: This invention provides compositions and methods for generating components of protein biosynthetic machinery including orthogonal tRNAs, orthogonal aminoacyl-tRNA synthetases, and orthogonal pairs of tRNAs/synthetases. Methods for identifying orthogonal pairs are also provided. These components can be used to incorporate unnatural amino acids into proteins in vivo.
    Type: Application
    Filed: December 10, 2004
    Publication date: September 22, 2005
    Applicant: The Scripps Research Institute
    Inventors: Peter Schultz, Lei Wang, John Anderson, Jason Chin, David Liu, Thomas Magliery, Eric Meggers, Ryan Mehl, Miro Pastrnak, Stephen Santoro, Zhiwen Zhang
  • Glycoprotein synthesis
    Publication number: 20050186657
    Abstract: Methods for making glycoproteins, both in vitro and in vivo, are provided. One method involves incorporating an unnatural amino acid into a protein and attaching one or more saccharide moieties to the unnatural amino acid. Another method involves incorporating an unnatural amino acid that includes a saccharide moiety into a protein. Proteins made by both methods can be further modified with additional sugars.
    Type: Application
    Filed: March 29, 2005
    Publication date: August 25, 2005
    Applicant: The Scripps Research Institute
    Inventors: Peter Schultz, Lei Wang, Zhiwen Zhang
  • Glycoprotein synthesis
    Publication number: 20050186656
    Abstract: Methods for making glycoproteins, both in vitro and in vivo, are provided. One method involves incorporating an unnatural amino acid into a protein and attaching one or more saccharide moieties to the unnatural amino acid. Another method involves incorporating an unnatural amino acid that includes a saccharide moiety into a protein. Proteins made by both methods can be further modified with additional sugars.
    Type: Application
    Filed: March 29, 2005
    Publication date: August 25, 2005
    Applicant: The Scripps Research Institute
    Inventors: Peter Schultz, Lei Wang, Zhiwen Zhang
  • Glycoprotein synthesis
    Publication number: 20050181471
    Abstract: Methods for making glycoproteins, both in vitro and in vivo, are provided. One method involves incorporating an unnatural amino acid into a protein and attaching one or more saccharide moieties to the unnatural amino acid. Another method involves incorporating an unnatural amino acid that includes a saccharide moiety into a protein. Proteins made by both methods can be further modified with additional sugars.
    Type: Application
    Filed: March 29, 2005
    Publication date: August 18, 2005
    Applicant: The Scripps Research Institute
    Inventors: Peter Schultz, Lei Wang, Zhiwen Zhang
  • Glycoprotein synthesis
    Patent number: 6927042
    Abstract: Methods for making glycoproteins, both in vitro and in vivo, are provided. One method involves incorporating an unnatural amino acid into a protein and attaching one or more saccharide moieties to the unnatural amino acid. Another method involves incorporating an unnatural amino acid that includes a saccharide moiety into a protein. Proteins made by both methods can be further modified with additional sugars.
    Type: Grant
    Filed: October 15, 2003
    Date of Patent: August 9, 2005
    Assignee: The Scripps Research Institute
    Inventors: Peter G. Schultz, Lei Wang, Zhiwen Zhang
  • Selective incorporation of 5-hydroxytryptophan into proteins in mammalian cells
    Publication number: 20050136513
    Abstract: This invention provides methods and compositions for incorporation of an unnatural amino acid into a peptide using an orthogonal aminoacyl tRNA synthetase/tRNA pair. In particular, an orthogonal pair is provided to incorporate 5-hydroxy-L-tryptophan in a position encoded by an opal mutation.
    Type: Application
    Filed: December 16, 2004
    Publication date: June 23, 2005
    Applicant: The Scripps Research Institute
    Inventors: Zhiwen Zhang, Lital Alfonta, Peter Schultz