Patents by Inventor Zhiwen Zhang

Zhiwen Zhang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Glycoprotein synthesis
    Publication number: 20050186657
    Abstract: Methods for making glycoproteins, both in vitro and in vivo, are provided. One method involves incorporating an unnatural amino acid into a protein and attaching one or more saccharide moieties to the unnatural amino acid. Another method involves incorporating an unnatural amino acid that includes a saccharide moiety into a protein. Proteins made by both methods can be further modified with additional sugars.
    Type: Application
    Filed: March 29, 2005
    Publication date: August 25, 2005
    Applicant: The Scripps Research Institute
    Inventors: Peter Schultz, Lei Wang, Zhiwen Zhang
  • Glycoprotein synthesis
    Publication number: 20050186656
    Abstract: Methods for making glycoproteins, both in vitro and in vivo, are provided. One method involves incorporating an unnatural amino acid into a protein and attaching one or more saccharide moieties to the unnatural amino acid. Another method involves incorporating an unnatural amino acid that includes a saccharide moiety into a protein. Proteins made by both methods can be further modified with additional sugars.
    Type: Application
    Filed: March 29, 2005
    Publication date: August 25, 2005
    Applicant: The Scripps Research Institute
    Inventors: Peter Schultz, Lei Wang, Zhiwen Zhang
  • Glycoprotein synthesis
    Publication number: 20050181471
    Abstract: Methods for making glycoproteins, both in vitro and in vivo, are provided. One method involves incorporating an unnatural amino acid into a protein and attaching one or more saccharide moieties to the unnatural amino acid. Another method involves incorporating an unnatural amino acid that includes a saccharide moiety into a protein. Proteins made by both methods can be further modified with additional sugars.
    Type: Application
    Filed: March 29, 2005
    Publication date: August 18, 2005
    Applicant: The Scripps Research Institute
    Inventors: Peter Schultz, Lei Wang, Zhiwen Zhang
  • Glycoprotein synthesis
    Patent number: 6927042
    Abstract: Methods for making glycoproteins, both in vitro and in vivo, are provided. One method involves incorporating an unnatural amino acid into a protein and attaching one or more saccharide moieties to the unnatural amino acid. Another method involves incorporating an unnatural amino acid that includes a saccharide moiety into a protein. Proteins made by both methods can be further modified with additional sugars.
    Type: Grant
    Filed: October 15, 2003
    Date of Patent: August 9, 2005
    Assignee: The Scripps Research Institute
    Inventors: Peter G. Schultz, Lei Wang, Zhiwen Zhang
  • Selective incorporation of 5-hydroxytryptophan into proteins in mammalian cells
    Publication number: 20050136513
    Abstract: This invention provides methods and compositions for incorporation of an unnatural amino acid into a peptide using an orthogonal aminoacyl tRNA synthetase/tRNA pair. In particular, an orthogonal pair is provided to incorporate 5-hydroxy-L-tryptophan in a position encoded by an opal mutation.
    Type: Application
    Filed: December 16, 2004
    Publication date: June 23, 2005
    Applicant: The Scripps Research Institute
    Inventors: Zhiwen Zhang, Lital Alfonta, Peter Schultz
  • Glycoprotein synthesis
    Publication number: 20040138106
    Abstract: Methods for making glycoproteins, both in vitro and in vivo, are provided. One method involves incorporating an unnatural amino acid into a protein and attaching one or more saccharide moieties to the unnatural amino acid. Another method involves incorporating an unnatural amino acid that includes a saccharide moiety into a protein. Proteins made by both methods can be further modified with additional sugars.
    Type: Application
    Filed: October 15, 2003
    Publication date: July 15, 2004
    Applicant: The Scripps Research Institute
    Inventors: Peter G. Schultz, Lei Wang, Zhiwen Zhang
  • Methods and compositions for the production of orthogonal tRNA-aminoacyltRNA synthetase pairs
    Publication number: 20030108885
    Abstract: This invention provides compositions and methods for generating components of protein biosynthetic machinery including orthogonal tRNAs, orthogonal aminoacyl-tRNA synthetases, and orthogonal pairs of tRNAs/synthetases. Methods for identifying orthogonal pairs are also provided. These components can be used to incorporate unnatural amino acids into proteins in vivo.
    Type: Application
    Filed: April 19, 2002
    Publication date: June 12, 2003
    Applicant: The Scripps Research Institute
    Inventors: Peter Schultz, Lei Wang, John Christopher Anderson, Jason W. Chin, David R. Liu, Thomas J. Magliery, Eric L. Meggers, Ryan Aaron Mehl, Miro Pastrnak, Stephen William Santoro, Zhiwen Zhang
  • In vivo incorporation of unnatural amino acids
    Publication number: 20030082575
    Abstract: The invention provides methods and compositions for in vivo incorporation of unnatural amino acids. Also provided are compositions including proteins with unnatural amino acids.
    Type: Application
    Filed: April 19, 2002
    Publication date: May 1, 2003
    Applicant: The Scripps Research Institute
    Inventors: Peter Schultz, Lei Wang, John Christopher Anderson, Jason William Chin, David R. Liu, Thomas J. Magliery, Eric L. Meggers, Ryan A. Mehl, Miro Pastrnak, Stephen William Santoro, Zhiwen Zhang