Benzazoles: benzoxazole, benzthiazole and benzimidazole derivatives

Info

Publication number: 20020049142
Type: Application
Filed: Jan 23, 2001
Publication Date: Apr 25, 2002
Patent Grant number: 6544989
Inventors: Christopher John Mathews (Bracknell), Russell Viner (Bracknell), Susan Patricia Barnett (Bracknell), Christopher John Urch (Bracknell), Stephen Christopher Smith (Bracknell), Patrick Jelf Crowley (Bracknell), William Guy Whittingham (Bracknell), Stephen Paul Heaney (Bracknell), John Williams (Bracknell), Torquil Eoghan Macleod Fraser (Bracknell), Eric Daniel Clarke (Bracknell), David John Hughes (Bracknell), Sarah Armstrong (Bracknell), Nigel John Barnes (Bracknell), Alan John Whittle (Camelford), Brian Leslie Pilkington (Maidenhead), John Pilkington (Maidenhead)
Application Number: 09767880

Abstract

1 A compund of formula (I) wherein X is O or S; n is 0 or 1; Y is O, S or NR7; R1 is hydrogen, halogen, C1-6 aklyl, C1-6 haloalkyl, C1-6 alkoxy, C1-6 haloalkoxy, C1-6 alkylthio, C1-6 haloalkylthio, C3-6 cycloalkyl, C1-6 alkoxy(C1-6)alkyl or SF5, R2 is hydrogen, halogen, C1-6 alkyl, C1-6 alkoxy, C1-6 haloalkoxy, C1-6 alkylthio, C1-6 haloalkylthio, C1-6 alkylsulfinyl, C1-6 haloalkylsulfinyl, C1-6 alkylsulfonyl, C1-6 haloalkylsulfonyl, C1-6 haloalkyl, cyano, nitro, CHO, CH═NOR5, C1-6 alkylcarbonyl, C1-6 alkoxycarbonyl or SF5; or together R1 and R2 form a five or six membered saturated or unsturated carbocyclic ring, optionally substituted processes for preparing these compounds, compositions comprising them, methods of using them to combat fungal diseases and methods of using them to combat or control insect, acarine, mollusc and nematode pests.

Description

Description

[0001] The present invention relates to isothiazole derivatives, to processes for preparing them, to fungicidal, insecticidal, acaricidal, molluscicidal and nematicidal compositions comprising them, to methods of using them to combat fungal diseases (especially fungal diseases of plants) and to methods of using them to combat and control insect, acarine, mollusc and nematode pests.

[0002] Isothiazole derivatives are disclosed in WO 95/31448, WO 97/18198, WO 98/02424 and WO 98/05670.

[0003] The present invention provides a compound of formula (I): 2

[0004] wherein X is O or S; n is 0 or 1; Y is O, S or NR7; R1 is hydrogen, halogen, C1-6 alkyl, C1-6 haloalkyl, C1-6 alkoxy, C1-6 haloalkoxy, C1-6 alkylthio, C1-6 haloalkylthio, C3-6 cycloalkyl, C1-6 alkoxy(C1-6)alkyl or SF5; R2 is hydrogen, halogen, C1-6 alkyl, C1-6 alkoxy, C1-6 haloalkoxy, C1-6 alkylthio, C1-6 haloalkylthio, C1-6 alkylsulfinyl, C1-6 haloalkylsulfinyl, C1-6 alkylsulfonyl, C1-6 haloalkylsulfonyl, C1-6 haloalkyl, cyano, nitro, CHO, CH═NOR5, C1-6 alkylcarbonyl, C1-6 alkoxycarbonyl or SF; or together R1 and R2 form a five or six membered saturated or unsaturated carbocyclic ring, optionally substituted by one or two C1-6 allyl groups; R3 is hydrogen, C1-6 alkyl, CH2(C1-4 haloalkyl), C1-6 cyanoalkyl, C3-6 alkenyl, C3-6 alkynyl, C1-6 alkoxy(C1-6)alkyl, C1-6 alkylthio(C1-6)alkyl, C1-6 alkoxy(C1-6)alkoxy(C1-6)alkyl, C1-6 alkylcarbonyl, C1-6 alkoxycarbonyl, formyl, C1-6 alkylcarbonyl(C1-6)alkyl, C1-6 alkoxycarbonyl(C1-6)alkyl, C1-6 alkylaminocarbonyl, di(C1-6)alkylanminocarbonyl, optionally substituted phenoxycarbonyl, optionally substituted phenyl(C1-4)alkyl or S(O)qR6; R4 is hydrogen, halogen, cyano, C1-8 alkyl, C1-6 haloalkyl, C1-6 cyanoakyl, C2-6 alkenyl, C2-6 alkynyl, C3-7 cycloalkyl, C3-7 halocycloalkyl, C3-7 cyanocycloalkyl, C1-3 alkyl(C3-7)cycloalkyl, C1-3 alkyl(C3-7)halocycloalkyl, C3-6 cycloalkyl(C1-6)alkyl, C5-6 cycloalkenyl, C5-6cycloalkenyl(C1-6)alkyl, C2-6 haloalkenyl, C1-6 cyanoalkenyl, C1-6 alkoxy(C1-6)alkyl, formyl, C1-6 carboxyalkyl, C1-6 alkylcarbonyl(C1-6)alkyl, C1-6 alkoxycarbonyl(C1-6)alkyl, C1-6 alkylthio(C1-6) alkyl, C1-6 alkylsulfinyl(C1-6)alkyl, C1-6 alkylsulfonyl(C1-6)alkyl, aminocarbonyl(C1-6)alkyl, C1-6 alkylaminocarbonyl(C1-6)alkyl, di(C1-6)alkylaninocarbonyl(C1-6)alkyl, C1-6 alkoxycarbonyl, C1-6 alkylcarbonyl, aminocarbonyl, C1-6 alkylaminocarbonyl, di(C1-6) alkylaminocarbonyl, optionally substituted phenyl, optionally substituted phenyl(C1-4 )alkyl, optionally substituted phenyl(C2-4)alkenyl, optionally substituted heteroaryl, optionally substituted heteroaryl(C1-4)alkyl, optionally substituted heterocyclyl, optionally substituted heterocyclyl(C1-4)alkyl, a group OR8, a group SH, a group S(O)pR9, a group NR10R11 or a group C(R12)=NOR13; R5 is hydrogen, C1-6 alkyl, optionally substituted phenyl or optionally substituted phenyl(C1-4)alkyl; R6 is C1-6 alkyl, C1-6 haloalkyl or optionally substituted phenyl; R7 is hydrogen, cyano, C1-8 alkyl, C1-6 haloalkyl, C1-6 cyanoalkyl, C2-6 alkenyl, C2-6 alkynyl, C3-7 cycloalkyl, C2-6 haloalkenyl, C3-4 cycloalkyl(C1-6)alkyl, C1-6 alkoxy(C1-6)alkyl, 1-6 alkoxycarbonyl, C1-6 alkylcarbonyl, C1-6 alkylaminocarbonyl, di(C1-6)alkylaminocarbonyl, optionally substituted phenyl or optionally substituted heteroaryl; R8 is hydrogen, C1-6 alkyl, C1-6 haloalkyl, C3-6 alkenyl, C1-4 cyanoalkyl, C1-6 alkoxycarbonyl(C1-6)alkyl, optionally substituted phenyl, optionally substituted phenyl(C1-4)alkyl, optionally substituted heteroaryl, N═C(CH3)2; R9 is C1-6 alkyl, C1-6 haloalkyl, C3-6 alkenyl, cyano, C1-4 cyanoalkyl, C1-6 alkoxycarbonyl(C1-6)alkyl, optionally substituted phenyl, optionally substituted phenyl(C,. 4)alkyl or optionally substituted heteroaryl; R10 and R11 are, indepently, hydrogen, C1-8 alkyl, C3-7 cycloalkyl, C3-6 alkenyl, C3-6 alkynyl, C2-6 haloalkyl, C1-6 alkoxy(C1-6)alkyl, C1-6 alkoxycarbonyl, optionally substituted phenoxycarbonyl, formyl, C1-6 alkylcarbonyl, C1-6 alkylSO2, optionally substituted phenylSO2 or optionally substituted phenyl(C1-4)alkyl; R12 is C1-3 alkyl; R13 is C1-6 alkyl, optionally substituted phenyl(C1-2)alkyl; and p and q are, independently, 0, 1 or 2.

[0005] The compounds of formula (I) may exist in different isomeric or tautomeric forms. This invention covers all such isomers and tautomers and mixtures thereof in all proportions.

[0006] In a further aspect the present invention provides a compound of formula (I) wherein X is O or S; n is 0 or 1; Y is O, S or NR7; R1 is hydrogen, halogen, C1-6 allyl, C1-6 haloalkyl, C1-6 alkoxy, C1-6 haloalkoxy, C1-6 alkylthio, C3-6 cycloalkyl or C1-6 alkoxy(C1-6)alkyl; R2 is hydrogen, halogen, C1-6 alkyl, C1-6 haloalkyl, cyano, nitro, CHO, CH═NOR5, C1-6 alkylcarbonyl, C1-6 alkoxycarbonyl or C1-6 alkylS(O)x; or together R1 and R2 form a five or six membered saturated or unsaturated carbocyclic ring, optionally substituted by one or two C1-6 alkyl groups; R3 is hydrogen, C1-6 alkyl, CH2(C1-4 haloalkyl), C3-6 alkenyl, C3-6 alkynyl, C1-6 alkoxy(C1-6)alkyl, C1-6 alkylcarbonyl, C1-6 alkoxycarbonyl, formyl, optionally substituted phenoxycarbonyl, optionally substituted phenyl(C1-4)allyl or S(O)yR25; R4 is hydrogen, halogen, cyano, optionally substituted alkyl, C1-8 alkoxy, C1-8 haloalkoxy, C1-8 alkylthio, C2-6 alkenyl, C2-6 alkynyl, C3-7cycloalkyl (optionally substituted with halogen or C1-6 alkyl), C5-6 cycloalkenyl (optionally substituted with halogen or C1-6 alkyl), C2-6 haloalkenyl, NHSO2R24, NHCOR24, CONR20R21, NR20R21, COR24, CO2R20, optionally substituted phenyl, optionally substituted heteroaryl or a group ZR26; R5 is hydrogen, C1-6 alkyl, optionally substituted phenyl or optionally substituted phenyl(C1-4)alkyl; R25 is C1-6 alkyl, C1-6 haloalkyl or optionally substituted phenyl; Z is O, S, SO, SO2 or NR27; R7 is hydrogen, cyano, C1-8 alkyl, C1-6 haloalkyl, C1-6 cyanoalkyl, C2-6 alkenyl, C2-6 alkynyl, C3-7 cycloalkyl, C2-6 haloalkenyl, C3-6 cycloalkyl(C1-6)alkyl, C1-6 alkoxy(C1-6)alkyl, C1-6 alkoxycarbonyl, C1-6 alkylcarbonyl, C1-6 alkylaminocarbonyl, di(C1-6)alkylaminocarbonyl, optionally substituted phenyl or optionally substituted heteroaryl; R26 and R27 are, independently, hydrogen, C1-8 alkyl, C3-6 alkenyl, C3-6 alkynyl, C1-6 alkoxy(C1-6)alkyl, C1-6 alkoxycarbonyl, optionally substituted phenoxycarbonyl, C1-6 alkylcarbonyl or optionally substituted phenyl(C1-4)alkyl, or R26 and R27 join to form a 5- or 6-membered saturated or unsaturated ring optionally containing another heteroatom selected from oxygen, sulfur and nitrogen; R20 and R21 are, independently, hydrogen or C1-6 alkyl; R24 is C1-6 alkyl or phenyl; and x and y are, independently, 0, 1 or 2.

[0007] Alkyl is straight or branched chain and is, for example, methyl, ethyl, n-propyl, n-butyl, n-pentyl, n-hexyl, iso-propyl, n-butyl, sec-butyl, iso-butyl, tert-butyl or neo-pentyl.

[0008] Halogen is fluorine, chlorine, bromine or iodine.

[0009] Haloalkyl groups are alwyl groups which are optionally substituted with one or more of the same or different halogen atoms and are, for example, CF3, CH2CF3 or CH2CHF2.

[0010] Phenyl(C1-4)alkyl is, for example, 1-phenyleth-1-yl, 2-phenyleth-1-yl, 2-phenylprop-2-yl, 3-phenylprop-1-yl, but is preferably benzyl. The term heteroaryl refers to an aromatic ring containing one or more heteroatoms (preferably one or two heteroatoms) selected from O, S and N. Examples of such rings include pyridine, pyrnmidine, furan, quinazoline, thiophene, thiazole, oxazole and isoxazole.

[0011] The term heterocyclyl refers to a non-aromatic ring containing one or more (preferably one or two) heteroatoms selected from O, S and N. Examples of such rings include 1,3-dioxolanyl, tetrrhydrofrryl and morpholinyl. It is preferred that heterocyclyl is optionally substituted by C1-6 alkyl.

[0012] Cycloalkenyl includes cyclopentenyl, cyclohexenyl and cyclohexadienyl.

[0013] It is preferred that phenyl moieties and heteroaryl groups are optionally substituted by one or more substituents independently selected from halogen, C1-6 alkyl, C1-6 haloalkyl, C1-6 alkoxy(C1-6)alkyl, C1-6 alkoxy, C1-6 haloalkoxy, C1-6 alkylthio, C1-6 haloalkylthio, C1-6 alkylsulfinyl, C1-6 haloalkylsulfinyl, C1-6 aIkylsulfonyl, C1-6 haloalkylsulfonyl, C2-6 alkenyl, C2-6 haloalkenyl, C2-6 alkynyl, C3-6 cycloalkyl, nitro, cyano, CO2H, C1-6 alkylcarbonyl, C1-6 alkoxycarbonyl, R14R15N or R16R17NC(O); wherein R14, R13, R16 and R17 are, independently, hydrogen or C1-6 allyl.

[0014] It is preferred that R1 is C1-2 alkyl, especially, methyl.

[0015] It is preferred that R2 is hydrogen, cyano or halogen, especially, halogen (especially bromo or chloro).

[0016] It is preferred that R3 is hydrogen, C1-6 alkyl or C1-6 alkoxy(C1-6)alkyl.

[0017] It is further preferred that R3 is hydrogen, ethyl or ethoxymethyl.

[0018] It is preferred that R4 is C1-6 alkoxy(C1-6)alkyl, C1-6 haloalkyl, (C1-6 alkyl)amino, di-(C1-6 alkyl)amino (such as N(C2H5)2 or N(C2H5)(CH[CH2]CH3)), morpholino, C1-6 alkyl or C1-6 alkoxy, especially morpholino, C1-6 alkyl or C1-6 alkoxy.

[0019] It is preferred that n is 0.

[0020] It is preferred that X is oxygen.

[0021] It is preferred that Y is oxygen or sulphur.

[0022] It is preferred that the compounds -of the invention are of formula (Ia).

[0023] In one particular aspect the present invention provides a compound of formula (Ia) wherein R1 is C1-4 alkyl (especially methyl or ethyl); R2 is hydrogen, halogen (especially chloro or bromo) or cyano; or R1 and R2 together form a cyclopentyl, cyclohexyl or phenyl ring; R3 is hydrogen, C1-4 alkyl (especially methyl or ethyl), C1-6 alkenyl (especially allyl), C1-6 alkynyl (especially propargyl), or C1-6 alkoxy(C1-6)alkyl (especially methoxymethyl and ethoxymethyl); n is 0; X and Y are both oxygen; and R4 is C1-6 alkyl [optionaly substituted with halogen, C1-4 alkoxy, C1-4 alkylthio, C1-4 haloalkylthio, alkylamino, dialkylamino (wherein the alkyl groups may form part of a five or six-membered ring, optionally containing one heteroatom such as oxygen or nitrogen), phenyl (itself optionally substituted with halogen), C3-6 cycloalkyl, C3-6 alkenyl, C3-6 alkynyl, C3-6 cycloalkyl, phenyl [optionally substituted with halogen, C1-4 haloalkyl (especially CF3), nitro, CO2H, or cyano] or heteroaryl (especiallypyridyl or pyrimidinyl) [optionally substituted with C1-4 alkyl or C1-4 haloalkyl]].

[0024] In one particular aspect the present invention provides a compound of formula (Ia) wherein R1 is C1-4alkyl (especially methyl or ethyl); R2 is hydrogen, halogen (especially chloro or bromo) or cyano; or R1 and R2 together form a cyclopentyl, cyclohexyl or phenyl ring; R3 is hydrogen, C1-4 alkyl (especially methyl or ethyl), phenyl(C1-4)alkyl (especially benzyl), C1-4 alkylcarbonyl (especially acetyl) or C1-4 alkylsulfonyl (especially methanesulfonyl); n is 0; X is oxygen; Y is oxygen or sulphur (especially oxygen); R4 is hydrogen, C1-8 alkyl [optionally substituted with halogen, C1-4 alkoxy, C4 alkylS(O)m, phenyl (itself optionally substituted with halogen), phenoxy, NR20R21, CO2H, CONR22R23, cyano, C3-6 cycloalkyl or CO(C1-6 alkoxy)], C1-8 alkoxy (optionally substituted with halogen), C1-8 alkylthio, C2-8 alkenyl (optionally substituted with halogen), NHSO2R24, NHCOR24, NR20R21, COR24, CO2R20, C2-8 alkynyl, C3-6 cycloalyl (optionally substituted with halogen or C1-6 alkyl), C5-6 cycloalkenyl, phenyl [optionally substituted with halogen, C1-4haloalkyl (especially CF3), C1-4 alkoxy, nitro, CO2R20 or cyano] or heteroaryl (especially pyridyl, pyrimidinyl, furanyl or thiophenyl) [optionally substituted with C1-6 alkyl, nitro or C1-4 haloalkyl]; R20, R21, R22 and R23 are, independently, hydrogen or C1-4 alkyl; R24 is C1-4 alkyl or phenyl; and m is 0, 1 or 2.

[0025] The physical parameter K concerns the relative solubility of a compound in n-octanol and water and, for a compound [A]: 1 K o / w = ( solubiltiy ⁢ ⁢ of ⁢ ⁢ compound ⁢ [ A ] ⁢ ⁢ in ⁢ ⁢ n ⁢ - ⁢ octanol ) ( solubility ⁢ ⁢ of ⁢ ⁢ compound ⁢ [ A ] ⁢ ⁢ in ⁢ ⁢ water )

[0026] In a further aspect the present invention provides a compound of formula (I) wherein log10Ko/w (calculated using the CLOGP3 program, available from BioByte Corp.,201 West 4th Street, Suite 204, Claremont, Calif. 91711, USA) of the compound is in the range zero to 8, preferably in the range 1 to 6 and more preferably in the range 1.2 to 5.2.

[0027] It will readily be seen that the side chain portion of formula (XIX): 3

[0028] is a portion of a compound of formula (I). The longest bond path of the side chain portion of formula (XIX) is the path involving the minimum number of bonds from the carbon labelled # to the furthest atom of the side chain, having an atomic weight greater than 10 Daltons. If there is more than one longest bond path, each involving the same minimum number of bonds, there is a set of longest bond paths.

[0029] In a further aspect of the present invention it is preferred that R4 is hydrogen, SH, C1-6 alkyl, C3-6 cycloalyl, C2-6 alkenyl, C2-5 alkynyl, C1-4 haloalkyl, C1-4 cyanoalkyl, C2-6 haloalkenyl, optionally substituted heterocyclyl(C1-4)alkyl, C2-6 cyanoalkenyl (such as 1-cyano-2-methylpropenyl), phenyl (optionally substituted with fluoro, chloro, bromo, nitro, cyano, C1-6 alkyl, C1-2 alkoxy, C1-4 haloalkyl (such as trifluoromethyl), C1-4 haloalkoxy (such as trifluoromethoxy), methanesulfonyl, methylenedioxy or di(C1-4 alkyl)amino (such as dimethylamino)), phenyl(C1-3)alkyl (phenyl optionally substituted with halogen, nitro, cyano, C1-6 alkyl, C1-2 alkoxy, C1-4 haloalkyl (such as trifluoromethyl), C1-4 haloalkoxy (such as trifluoromethoxy), methanesulfonyl, or methylenedioxy), formyl, optionally substituted heterocyclyl, optionally substituted heteroaryl, optionally substituted heteroaryl(C1-4)alkyl, C1-2 alkylcarbonyl, C1-4 alkoxycarbonyl, C1-5 alkoxycarbonyl(C1,)4alkyl, a group NR10R11, a group OR8, C1-4 alkoxymethyl, chlorine, a group SR9, or a group C(R12)═NOR13; R8 is hydrogen, C1-5 alkyl, C1-4 haloalkyl (such as 2,2,2-trifluoroethyl), C2-4 alkenyl (such as allyl), phenyl (optionally substituted with fluoro, chloro, bromo, nitro, cyano, C1-6 alkyl, C1-2 alkoxy, C1-4 haloalkyl (such as trifluoromethyl), C1-4 haloalkoxy (such as trifluoromethoxy), methanesulfonyl, or methylenedioxy), phenyl(CH) (phenyl optionally substituted with fluoro, chloro, bromo, nitro, cyano, C1-6 alkyl, C1-2 alkoxy, C1-4 haloalkyl (such as trifluoromethyl), C1-4 haloalkoxy (such as trifluoromethoxy), methanesulfonyl, or methylenedioxy), N═C(CH3)2; R9 is C1-5 alkyl, phenyl (optionally substituted with fluoro, chloro, bromo, nitro, cyano, C1-6 alkyl, C1-2 alkoxy, C1-4 haloalkyl (such as trifluoromethyl), C1-4 haloalkoxy (such as trifluoromethoxy), methanesulfonyl, methylenedioxy or di(C1-4 alkyl)amino (such as dimethylamino)), C1-2 haloalkyl, cyano, cyanomethyl or C1-2 alkoxycarbonylmethyl; R10 and R11 are, independently, hydrogen, C1-4 alkyl, C5-6 cycloalkyl, formyl, C1-3alkylcarbonyl, phenoxycarbonyl, C1-2 alkylSO2 or phenylSO2; R12 is C1-2 alkyl; R13 is C1-2 alkyl or benzyl; heterocyclyl is, for example, tetrahydrofuryl, 1,3-dioxolanyl or morpholinyl; an example of an optional substituent for heterocyclyl is C1-4 alkyl; heteroaryl is, for example, thienyl, furyl, pyridyl, quinazolinyl, pyrazolyl or isoxazolyl; and examples of optional substituents for heteroaryl include C1-6 alkyl, C1-6 haloalkyl and phenoxy.

[0030] In a further aspect the present invention provides a compound of formula (I) wherein the side chain portion of formula (XIX) is such that each atom having an atomic weight greater than 10 Daltons in the side chain portion is no more than four bond lengths away from any of the atoms present in the longest bond path or one of the longest bond paths.

[0031] In another aspect the present invention provides a compound of formula (Ia) or (Ib) wherein R1 is C1-2 alkyl, chloro, CF3, OCH3 or SCH3; R2 is hydrogen, halogen (such as fluorine, chlorine or bromine), cyano, nitro, C1-4alkyl (such as methyl), C1-4alkoxy (such methoxy) or SCH3; or R1 and R2 join to form a C3-7cycloalkyl (such as cyclopentyl or cyclohexyl) or phenyl ring; R3 is hydrogen, C1-6 alkyl optionally substituted with cyano, halogen, (C1-6)alkoxy, (C1-6)alkoxy(C1-4)alkoxy, C1-4alkoxycarbonyl, phenyl or C1-4 alkylthio (such as methyl, ethyl, n-propyl, iso-propyl, cyanomethyl, 2,2,2-trifluoroethyl, (C1-2)alkoxymethyl, methoxyethoxymethyl, methoxycarbonylmethyl, phenylmethyl or methylthiomethyl), C3-6 alkenyl (such as allyl), C3-6 alkynyl (such as propargyl), carbonyl substituted with C1-6alkoxy, C1-4alkylamino or di(C1-4alkyl)amino (such as C1-2 alkoxycarbonyl, methylaminocarbonyl or dimethylaminocarbonyl), C1-4alkylthio (such as methylthio) or phenylthio; X is oxygen or sulphur; Y is oxygen, sulphur or NR7; n is 0; R4 is hydrogen, SH, C1-6 alkyl, C3-6 cycloalkyl, C2-6 alkenyl, C2-5 alkynyl, C1-4 haloalkyl, C1-4 cyanoalkyl, C2-6 haloalkenyl, optionally substituted heterocyclyl(C1-4)allyl, 1-cyano-2-methylpropenyl, phenyl (optionally substituted with fluoro, chloro, bromo, nitro, cyano, C1-2 alkyl, tert-butyl, C1-2 alkoxy, trifluoromethyl, trifluoromethoxy, methanesulfonyl, methylenedioxy or dimethylamino), phenyl(C1-3)alkyl (phenyl optionally substituted with fluorine), formyl, optionally substituted heteroyclyl, optionally substituted heteroaryl, optionally substituted heteroaryl(C1-4)alkyl, C1-2 alkylcarbonyl, C1-4 alkoxycarbonyl, C1-5 alkoxycarbonyl(C1-4)alkyl, a group NR10R11, a group OR8, C1-4 alkoxymethyl, chlorine, a group SR9, or a group C(R12)═NOR13; R7 is hydrogen or C1-4alkyl (such as methyl); R8 is hydrogen, C1-5 alkyl, 2,2,2-trifluoroethyl, allyl, phenyl (optionally substituted with chloro), phenyl(CH2) (phenyl optionally substituted with fluoro, chloro), N═C(CH3)2; R9 is C1-5 alkyl, phenyl C1-2haloalkyl, cyano, cyanomethyl or C1-2 alkoxycarbonylmethyl; R10 and R11 are, independently, hydrogen, C1-4alkyl, C5-6 cycloalkyl, formyl, C1-3 alkylcarbonyl, phenoxycarbonyl, C1-2 alkylSO2 or phenylSO2; R12 is C1-2 alkyl; R13 is C1-2alkyl or benzyl; heterocyclyl is, for example, tetrahydrofuryl, 1,3-dioxolanyl or morpholinyl; an example of an optional substituent for heterocyclyl is C1-4alkyl; heteroaryl is, for example, thienyl, furyl, pyridyl, quinazolinyl, pyrazolyl or isoxazolyl; and examples of optional substituents for heteroaryl include C1-6 alkyl, C1-6 haloalkyl and phenoxy. Specific preferred values of R4 are recited in Table A1.

[0032] The compounds in the following Tables illustrate compounds of the invention. Table A1 provides 352 compounds of formula (Ia) wherein R1 is methyl; R2 is hydrogen; R3 is hydrogen; X and Y are each oxygen; n is 0; and R4 is as defined in the Table. 1 TABLE A1 Compound Number R4 1 H 2 CH3 3 CH2CH3 4 CH2CH2CH3 5 CH2CH2CH2CH3 6 CH2CH2CH2CH2CH3 7 CH2CH2CH2CH2CH2CH3 8 CH(CH3)2 9 C(CH3)3 10 CH(CH3)CH2CH3 11 CH2CH(CH3)CH2CH3 12 CH(CH3)CH2CH2CH3 13 CH(CH2CH3)2 14 CH2CH(CH3)2 15 CH2C(CH3)3 16 CH2CH2CH(CH3)2 17 CH2CH2C(CH3)3 18 C(CH3)2CH3 19 C(CH3)2CH2CH3 20 C(CH3)2CH2CH2CH3 21 cyclopropyl 22 1-methylcyclopropyl 23 2-methylcyclopropyl 24 1-cyanocyclopropyl 25 2,2-dichloro-3,3-dimethylcyclopropyl 26 2,2-dichloro-1-ethyl-3-methylcyclopropyl 27 cyclobutyl 28 cyclopentyl 29 1-methylcyclopentyl 30 1-cyclopentenyl 31 2-cyclopentenyl 32 3-cyclopentenyl 33 2-cyclopentenylmethyl 34 1-cyclopentenylmethyl 35 cyclohexyl 36 1-methylcyclohexyl 37 1-cyclohexenyl 38 2-cyclohexenyl 39 cyclohexylmethyl 40 2-cyclohexenylmethyl 41 cyclopropylmethyl 42 cyclopentylmethyl 43 2-cyclopentylethyl 44 CH═CH2 45 CH═CHCH3 46 CH═C(CH3)2 47 C(CH3)═CHCH3 48 CH═CHCH2CH2CH3 49 C(CH3)═C(CH3)2 50 CH═CHCH(CH3)2 51 CH2CH═CH2 52 CH2CH═CHCH3 53 CH2CH═C(CH3)2 54 CH2C(CH3)═CH2 55 CH2C(CH3)═CHCH3 56 CH2C(CH3)═C(CH3)2 57 CH2CH2CH═CH2 58 C(CH3)═CHCH3 59 C(CH3)2CH═CH2 60 C(CH3)═CHCH2CH3 61 CH═CHCH═CHCH3 62 cyclopentyldienyl 63 4-nitrostyryl 64 C≡CH 65 C≡CCH3 66 C≡CCH2CH3 67 CH2C≡CH 68 CH(CH3)C≡CH 69 C(CH3)2C≡CH 70 CH2CH2C≡CH 71 CH2CH2C≡CCH3 72 CH2CH2COCH3 73 CH2F 74 CHF2 75 CF3 76 CF(CH3)2 77 CH2CF3 78 CF2CF3 79 CF2CHF2 80 CF2CF2CF3 81 CF2CF2CF2CF3 82 CF═CFCF2CF3 83 CF2Cl 84 CF2Br 85 CFClCF3 86 CF2CF2Cl 87 CF2CFClCF3 88 CFBrCF3 89 CH2Cl 90 CH2CH2Cl 91 CH2CH2CH2Cl 92 CH2CH2CH2CH2Cl 93 CH(Cl)CH3 94 CH(Cl)—C6H5 95 CH(Cl)CH2CH3 96 CH(Cl)CH2Cl 97 CCl(CH3)2 98 C(CH3)2CH2Cl 99 CHCl2 100 C(CH2Cl)2CH3 101 C(CH3)2CHCl2 102 CH2CH(Cl)CH3 103 CCl3 104 CCl2CCl3 105 CH═CHCl 106 CCl═CH2 107 CCl═CCl2 108 CH2Br 109 CHBr2 110 C(CH3)2Br 111 CH(Br)CH(CH3)2 112 C(CH3)BrCH2Br 113 CH2CN 114 CH2CH2CN 115 CH(CH3)CN 116 C(CH3)2CN 117 CH2CH(CH3)CN 118 CH2C(CH3)2CN 119 C(CN)═C(CH3)2 120 CH2CO2CH3 121 CH2CO2CH2CH3 122 CH2CO2C(CH3)3 123 CH(CH3)CO2CH3 124 CH(CH3)CO2CH2CH3 125 CH(CH3)CO2C(CH3)3 126 C(CH3)2CO2CH3 127 C(CH3)2CO2CH2CH3 128 C(CH3)2CO2C(CH3)3 129 CH2C(CH3)2CH2CO2CH2CH3 130 CH2OCH3 131 CH2OCH2CH3 132 CH2CH2OCH3 133 CH2OCH(CH3)2 134 CH2OC(CH3)3 135 C(CH3)2OCOCH3 136 C(CH3)2OH 137 CH2OCH2CH2OCH3 138 CH2OCH2CH2OCH2CH3 139 CH2CH2OH 140 CH2O—C6H5 141 CH(CH3)O—C6H5 142 1-methyl-1-(4-chlorophenoxy)ethyl 143 2-nitrophenoxymethyl 144 4-nitrophenoxymethyl 145 2-tetrahydrofuryl 146 3-tetrahydrofuryl 147 2-tetrahydrofurylmethyl 148 3-tetrahydrofurylmethyl 149 (1,3-dioxolan-2-yl)methyl 150 (2-methyl-1,3-dioxolan-2-yl)methyl 151 (1,3-dioxolan-4-yl)methyl 152 (2-methyl-1,3-dioxolan-4-yl)methyl 153 CHO 154 COCH3 155 COCH2CH3 156 CO2CH3 157 CO2CH2CH3 158 CO2CH(CH3)2 159 CO2C(CH3)3 160 CO2C(CH3)2CH2CH3 161 CH2CH2CO2H 162 CH2CH2CO2CH3 163 CH2CH2CO2CH2CH3 164 CH2CH2CH2CO2CH3 165 CH2CH2CH2CO2CH2CH3 166 CH═NOH 167 C(CH3)═NOCH3 168 C(CH3)═NOH 169 C(CH3)═NOCH3 170 C(CH3)═NOCH2—C6H5 171 CH2SCH3 172 CH2CH2SCH3 173 CH2S—C6H5 174 Cl 175 NH2 176 NHCH3 177 NHCH2CH3 178 NHCH2CH2CH3 179 N(CH3)2 180 N(CH3)CH2CH3 181 N(CH2CH3)2 182 NHCH(CH3)2 183 NHC(CH3)3 184 N(CH3)CH(CH3)2 185 N(CH3)C(CH3)3 186 NH-cyclopentyl 187 NH-cyclohexyl 188 N(CH3)-cyclopentyl 189 N(CH3)-cyclohexyl 190 N(CH2CH3)-cyclohexyl 191 morpholino 192 NHCHO 193 NHCOCH3 194 NHCOCH2CH3 195 NHCOCH(CH3)2 196 NHCO—C6H5 197 N(CH3)CHO 198 N(CH3)COCH3 199 N(CH3)COCH2CH3 200 NHSO2CH3 201 NHSO2CH2CH3 202 NHSO2—C6H5 203 OCH3 204 OCH2CH3 205 OCH2CH2CH3 206 OCH(CH3)2 207 OC(CH3)3 208 OCH2CH(CH3)2 209 OCH(CH3)CH2CH3 210 OCH2CF3 211 OCH2C(CH3)3 212 OCH2—C6H5 213 4-fluorobenzyloxy 214 2,4-dichlorobenzyloxy 215 OCH2CH═CH2 216 O—C6H5 217 2-chlorophenoxy 218 4-chlorophenoxy 219 O—N═C(CH3)2 220 SCH3 221 SCH2CH3 222 S(CH2)2CH3 223 SCH(CH3)2 224 SC(CH3)3 225 SCH2CH(CH3)2 226 SCH2C(CH3)3 227 S—C6H5 228 SCH2CN 229 SCH2CO2CH3 230 SCH2CO2CH2CH3 231 SCHF2 232 SCF3 233 SCH2CF3 234 SCF2CF2H 235 SCN 236 CH2C6H5 237 CH(CH3)C6H5 238 C(CH3)2C6H5 239 CH2C6F5 240 3,5-diF—C6H3 241 3-CH3O—C6H4 242 4-F—C6H4 243 4-F—C6H4 244 2,6-diCl-4-CF3—C6H2 245 CH(CH2CH3)C6H5 246 CH(C6H5)2 247 CH2CH2C6H5 248 C6H5 249 2-Br—C6H4 250 3-Br—C6H4 251 4-Br—C6H4 252 4-tert-butyl-C6H4 253 2-Cl—C6H4 254 3-Cl—C6H4 255 4-Cl—C6H4 256 2,3-diCl—C6H3 257 2,4-diCl—C6H3 258 2,5-diCl—C6H3 259 2,6-diCl—C6H3 260 3,4-diCl—C6H3 261 3,5-diCl—C6H3 262 2,4,6-triCl—C6H2 263 C6Cl5 264 2-Cl-4-F—C6H3 265 2-Cl-6-F—C6H3 266 4-Cl-2,5-diF—C6H2 267 2-Cl-4-NO2—C6H3 268 2-Cl-4-CF3—C6H3 269 2-Cl-6-CF3—C6H3 270 2-Cl-4-methanesulfonyl-C6H3 271 2,4-diCl-5-F—C6H2 272 2-F—C6H4 273 3-F—C6H4 274 4-F—C6H4 275 2,3-diF—C6H3 276 2,4-diF—C6H3 277 2,5-diF—C6H3 278 2,6-diF—C6H3 279 3,4-diF—C6H3 280 3,5-diF—C6H3 281 2,3,4-triF—C6H2 282 2,3,5-triF—C6H2 283 2,3,6-triF—C6H2 284 2,4,6-triF—C6H2 285 3,4,5-triF—C6H2 286 2,3,4,5-tetraF—C6H 287 C6F5 288 2-F-3-CF3—C6H3 289 2-F-4-CF3—C6H3 290 2-F-5-CF3—C6H3 291 2-F-6-CF3—C6H3 292 4-F-2-CF3—C6H3 293 4-F-3-CF3—C6H3 294 5-F-2-CF3—C6H3 295 2-CN—C6H4 296 3-CN—C6H4 297 4-CN—C6H4 298 4-dimethylaminophenyl 299 2-C2H5O—C6H4 300 3-C2H5O—C6H4 301 4-C2H5O—C6H4 302 2-C2H5—C6H4 303 3-C2H5—C6H4 304 4-C2H5—C6H4 305 2-CH3O—C6H4 306 3-CH3O—C6H4 307 4-CH3O—C6H4 308 3,4-diCH3O—C6H3 309 3,5-diCH3O—C6H3 310 2,6-diCH3O—C6H3 311 3,4-(methylenedioxy)phenyl 312 2-CH3—C6H4 313 3-CH3—C6H4 314 4-CH3—C6H4 315 2,3-diCH3—C6H3 316 2,4-diCH3—C6H3 317 2,5-diCH3—C6H3 318 2,6-diCH3—C6H3 319 3,4-diCH3—C6H3 320 2,4,6-triCH3—C6H2 321 2-NO2—C6H4 322 3-NO2—C6H4 323 4-NO2—C6H4 324 4-methanesulfonyl-2-nitrophenyl 325 3-trifluoromethoxyphenyl 326 2-trifluoromethylphenyl 327 3-trifluoromethylphenyl 328 4-trifluoromethylphenyl 329 4-carboxymethylphenyl 330 2-thienyl 331 3-chloro-2-thienyl 332 3,4,5-trichloro-2-thienyl 333 2-benzothiophenyl 334 2-thienylmethyl 335 5-tert-butyl-2-furyl 336 5-nitro-2-furyl 337 pyridin-2-yl 338 pyridin-3-yl 339 pyridin-4-yl 340 3-chloro-2-pyridyl 341 6-chloro-2-pyridyl 342 2,6-dichloro-4-pyridyl 343 2-chloro-3-pyridyl 344 2-phenoxy-3-pyridyl 345 2-quinazolinyl 346 4-biphenyl 347 1,3-dimethyl-5-pyrazolyl 348 4-chloro-1,3-dimethyl-5-pyrazolyl 349 5-isoxazolyl 350 6-trifluoromethyl-2-pyridyl 351 OH 352 SH

TABLE A2

[0033] Table A2 provides 352 compounds of formula (Ia) wherein R1 is methyl; R2 is fluoro; R3 is hydrogen; X and Y are each oxygen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE A3

[0034] Table A3 provides 352 compounds of formula (Ia) wherein R1 is methyl; R2 is chloro; R3 is hydrogen; X and Y are each oxygen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE A4

[0035] Table A4 provides 352 compounds of formula (Ia) wherein R1 is methyl; R2 is bromo; R3 is hydrogen; X and Y are each oxygen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE A5

[0036] Table A5 provides 352 compounds of formula (Ia) wherein R1 is methyl; R2 is cyano; R3 is hydrogen; X and Y are each oxygen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE A6

[0037] Table A6 provides 352 compounds of formula (Ia) wherein R1 is ethyl; R2 is hydrogen; R3 is hydrogen; X and Y are each oxygen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE A7

[0038] Table A7 provides 352 compounds of formula (Ia) wherein R1 is ethyl; R2 is fluoro; R3 is hydrogen; X and Y are each oxygen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE A8

[0039] Table A8 provides 352 compounds of formula (Ia) wherein R1 is ethyl; R2 is chloro; R3 is hydrogen; X and Y are each oxygen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE A9

[0040] Table A9 provides 352 compounds of formula (Ia) wherein R1 is ethyl; R2 is bromo; R3 is hydrogen; X and Y are each oxygen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE A10

[0041] Table A10 provides 352 compounds of formula (Ia) wherein R1 is ethyl; R2 is cyano; R3 is hydrogen; X and Y are each oxygen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLEA11

[0042] Table A11 provides 352 compounds of formula (Ia) wherein R1 is methyl; R2 is hydrogen; R3 is hydrogen; X is oxygen; Y is sulphur; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE A12

[0043] Table A12 provides 352 compounds of formula (Ia) wherein R1 is methyl; R2 is fluoro; R3 is hydrogen; X is oxygen; Y is sulphur, n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE A13

[0044] Table A13 provides 352 compounds of formula (Ia) wherein R1 is methyl; R2 is chloro; R3 is hydrogen; X is oxygen; Y is sulphur, n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE A14

[0045] Table A14 provides 352 compounds of formula (Ia) wherein R1 is methyl; R2 is bromo; R3 is hydrogen; X is oxygen; Y is sulphur, n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE A15

[0046] Table A15 provides 352 compounds of formula (Ia) wherein R1 is methyl; R2 is cyano; R3 is hydrogen; X is oxygen; Y is sulphur, n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE A16

[0047] Table A16 provides 352 compounds of formula (Ia) wherein R1 is ethyl; R2 is hydrogen; R3 is hydrogen; X is oxygen; Y is sulphur; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE A17

[0048] Table A17 provides 352 compounds of formula (Ia) wherein R1 is ethyl; R2 is fluoro; R3 is hydrogen; X is oxygen; Y is sulphur; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE A18

[0049] Table A18 provides 352 compounds of formula (Ia) wherein R1 is ethyl; R2 is chloro; R3 is hydrogen; X is oxygen; Y is sulphur, n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE A19

[0050] Table A19 provides 352 compounds of formula (Ia) wherein R1 is ethyl; R2 is bromo; R3 is hydrogen; X is oxygen; Y is sulphur, n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE A20

[0051] Table A20 provides 352 compounds of formula (Ia) wherein R1 is ethyl; R2 is cyano; R3 is hydrogen; X is oxygen; Y is sulphur; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE A21

[0052] Table A21 provides 352 compounds of formula (Ib) wherein R1 is methyl; R2 is hydrogen; R3 is hydrogen; X and Y are each oxygen; n is 0; and the values of RT match those of the correspondingly numbered compounds of Table A1.

TABLE A22

[0053] Table A22 provides 352 compounds of formula (Ib) wherein R1 is methyl; R2 is fluoro; R3 is hydrogen; X and Y are each oxygen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE A23

[0054] Table A23 provides 352 compounds of formula (Ib) wherein R1 is methyl; R2 is chloro; R3 is hydrogen; X and Y are each oxygen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE A24

[0055] Table A24 provides 352 compounds of formula (Ib) wherein R1 is methyl; R2 is bromo; R3 is hydrogen; X and Y are each oxygen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE A25

[0056] Table A25 provides 352 compounds of formula (Ib) wherein R1 is methyl; R2 is cyano; R3 is hydrogen; X and Y are each oxygen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE A26

[0057] Table A26 provides 352 compounds of formula (Ib) wherein R1 is ethyl; R2 is hydrogen; R3 is hydrogen; X and Y are each oxygen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE A27

[0058] Table A27 provides 352 compounds of formula (Ib) wherein R1 is ethyl; R2 is fluoro; R3 is hydrogen; X and Y are each oxygen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE A28

[0059] Table A28 provides 352 compounds of formula (Ib) wherein R1 is ethyl; R2 is chloro; R3 is hydrogen; X and Y are each oxygen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE A29

[0060] Table A29 provides 352 compounds of formula (Ib) wherein R1 is ethyl; R2 is bromo; R3 is hydrogen; X and Y are each oxygen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE A30

[0061] Table A30 provides 352 compounds of formula (Ib) wherein R1 is ethyl; R2 is cyano; R3 is hydrogen; X and Y are each oxygen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE A31

[0062] Table A31 provides 352 compounds of formula (Ib) wherein R1 is methyl; R2 is hydrogen; R3 is hydrogen; X is oxygen; Y is sulphur; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE A32

[0063] Table A32 provides 352 compounds of formula (Ib) wherein R1 is methyl; R2 is fluoro; R3 is hydrogen; X is oxygen; Y is sulphur, n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE A33

[0064] Table A33 provides 352 compounds of formula (Ib) wherein R1 is methyl; R2 is chloro; R3 is hydrogen; X is oxygen; Y is sulphur; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE A34

[0065] Table A34 provides 352 compounds of formula (Ib) wherein R1 is methyl; R2 is bromo; R3 is hydrogen; X is oxygen; Y is sulphur; n is 0; and the values of R4 match those of is the correspondingly numbered compounds of Table A1.

TABLE A35

[0066] Table A35 provides 352 compounds of formula (Ib) wherein R1 is methyl; R2 is cyano; R3 is hydrogen; X is oxygen; Y is sulphur; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE A36

[0067] Table A36 provides 352 compounds of formula (Ib) wherein R1 is ethyl; R2 is hydrogen; R3 is hydrogen; X is oxygen; Y is sulphur; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE A37

[0068] Table A37 provides 352 compounds of formula (Ib) wherein R1 is ethyl; R2 is fluoro; R3 is hydrogen; X is oxygen; Y is sulphur, n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE A38

[0069] Table A38 provides 352 compounds of formula (Ib) wherein R1 is ethyl; R2 is chloro; R3 is hydrogen; X is oxygen; Y is sulphur; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE A39

[0070] Table A39 provides 352 compounds of formula (Ib) wherein R1 is ethyl; R2 is bromo. R3 is hydrogen; X is oxygen; Y is sulphur; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE A40

[0071] Table A40 provides 352 compounds of formula (Ib) wherein R1 is ethyl; R2 is cyano; R3 is hydrogen; X is oxygen; Y is sulphur; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE A41

[0072] Table A41 provides 352 compounds of formula (Ib) wherein R1 is methyl; R2 is hydrogen; R3 is hydrogen; X is oxygen; Y is NR7; R1 is hydrogen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE A42

[0073] Table A42 provides 352 compounds of formula (Ib) wherein R1 is methyl; R2 is fluoro; R3 is hydrogen; X is oxygen; Y is NR7; R7 is hydrogen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE A43

[0074] Table A43 provides 352 compounds of formula (Ib) wherein R1 is methyl; R2 is chloro; R3 is hydrogen; X is oxygen; Y is NRC; R7 is hydrogen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE A44

[0075] Table A44 provides 352 compounds of formula (Ib) wherein R1 is methyl; R2 is bromo; R3 is hydrogen; X is oxygen; Y is NR7; R7 is hydrogen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE A45

[0076] Table A45 provides 352 compounds of formula (Ib) wherein R1 is methyl; R2 is cyano; R3 is hydrogen; X is oxygen; Y is NR7; R7 is hydrogen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE A46

[0077] Table A46 provides 352 compounds of formula (Ib) wherein R1 is ethyl; R2 is hydrogen; R3 is hydrogen; X is oxygen; Y is NR7; R7 is hydrogen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE A47

[0078] Table A47 provides 352 compounds of formula (Ib) wherein R1 is ethyl; R2 is fluoro; R3 is hydrogen; X is oxygen; Y is NR7; R7 is hydrogen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE A48

[0079] Table A48 provides 352 compounds of formula (Ib) wherein R1 is ethyl; R2 is chloro; R3 is hydrogen; X is oxygen; Y is NR7; R7 is hydrogen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE A49

[0080] Table A49 provides 352 compounds of formula (Ib) wherein R1 is ethyl; R2 is bromo; R3 is hydrogen; X is oxygen; Y is NR7; R7 is hydrogen; n is 0; and the values of R4 match ?5 those of the correspondingly numbered compounds of Table A1.

TABLE A50

[0081] Table A50 provides 352 compounds of formula (Ib) wherein R1 is ethyl; R2 is cyano; R3 is hydrogen; X is oxygen; Y is NR7; R7 is hydrogen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE A51

[0082] Table A51 provides 352 compounds of formula (Ib) wherein R1 is methyl; R2 is hydrogen; R3 is hydrogen; X is oxygen; Y is NR7; R7 is methyl; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE A52

[0083] Table A52 provides 352 compounds of formula (Ib) wherein R1 is methyl; R2 is fluoro; R3 is hydrogen; X is oxygen; Y is NR7; R7 is methyl; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE A53

[0084] Table A53 provides 352 compounds of formula (Ib) wherein R1 is methyl; R2 is chloro; R3 is hydrogen; X is oxygen; Y is NR7; R7 is methyl; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE A54

[0085] Table A54 provides 352 compounds of formula (Ib) wherein R1 is methyl; R2 is bromo; R3 is hydrogen; X is oxygen; Y is NR7; R7 is methyl; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE A55

[0086] Table A55 provides 352 compounds of formula (Ib) wherein R1 is methyl; R2 is cyano; R3 is hydrogen; X is oxygen; Y is NR7; R7 is methyl; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE A56

[0087] Table A56 provides 352 compounds of formula (Ib) wherein R1 is ethyl; R2 is hydrogen; R3 is hydrogen; X is oxygen; Y is NR7; R7 is methyl; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE A57

[0088] Table AS7 provides 352 compounds of formula (ab) wherein R1 is ethyl; R2 is fluoro; R3 is hydrogen; X is oxygen; Y is NR7; R7 is methyl; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE A58

[0089] Table A58 provides 352 compounds of formula (Ib) wherein R1 is ethyl; R2 is chloro; R3 is hydrogen; X is oxygen; Y is NR7; R7 is methyl; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE A59

[0090] Table A59 provides 352 compounds of formula (Ib) wherein R1 is ethyl; R2 is bromo; R3 is hydrogen; X is oxygen; Y is NR7; R7 is methyl; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE A60

[0091] Table A60 provides 352 compounds of formula (Ib) wherein R1 is ethyl; R2 is cyano; R3 is hydrogen; X is oxygen; Y is NR7; R7 is methyl; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE A61

[0092] Table A61 provides 352 compounds of formula (Ia) wherein R1 is methyl; R2 is hydrogen; R3 is hydrogen; X is oxygen; Y is NR7; R1 is methyl; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE A62

[0093] Table A62 provides 352 compounds of formula (Ia) wherein R1 is methyl; R2 is fluoro; R3 is hydrogen; X is oxygen; Y is NR7; R7 is methyl; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE A63

[0094] Table A63 provides 352 compounds of formula (Ia) wherein R1 is methyl; R2 is chloro; R3 is hydrogen; X is oxygen; Y is NRC; R7 is methyl; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE A64

[0095] Table A64 provides 352 compounds of formula (Ia) wherein R1 is methyl; R2 is bromo; R3 is hydrogen; X is oxygen; Y is NR7; R7 is methyl; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE A65

[0096] Table A65 provides 352 compounds of formula(ab) wherein R1 is methyl; R2 is cyano; R3 is hydrogen; X is oxygen; Y is NR7; R7 is methyl; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE A66

[0097] Table A66 provides 352 compounds of formula (Ia) wherein R1 is ethyl; R2 is hydrogen; R3 is hydrogen; X is oxygen; Y is NR7; R7 is methyr; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE A67

[0098] Table A67 provides 352 compounds of formula (Ia) wherein R1 is ethyl; R2 is fluoro; R3 is hydrogen; X is oxygen; Y is NR7; R7 is methyl; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE A68

[0099] Table A68 provides 352 compounds of formula (Ia) wherein R1 is ethyl; R2 is chloro; R3 is hydrogen; X is oxygen; Y is NR7; R7 is methyl; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE A69

[0100] Table A69 provides 352 compounds of formula (Ia) wherein R1 is ethyl; R2 is bromo; R3 is hydrogen; X is oxygen; Y is NR7; R7 is methyl; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE A70

[0101] Table A70 provides 352 compounds of formula (Ia) wherein R1 is ethyl; R2 is cyano; R3 is hydrogen; X is oxygen; Y is NR7; R4 is methyl; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE B1

[0102] Table B1 provides 352 compounds of formula (Ia) wherein R1 is methyl; R2 is hydrogen; R3 is methyl; X and Y are each oxygen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE B2

[0103] Table B2 provides 352 compounds of formula (Ia) wherein R1 is methyl; R2 is fluoro; is R3 is methyl; X and Y are each oxygen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE B3

[0104] Table B3 provides 352 compounds of formula (Ia) wherein R1 is methyl; R2 is chloro; R3 is methyl; X and Y are each oxygen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE B4

[0105] Table B4 provides 352 compounds of formula (Ia) wherein R! is methyl, R2 is bromo; R3 is methyl; X and Y are each oxygen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE B5

[0106] Table B5 provides 352 compounds of formula (Ia) wherein R1 is methyl; R2 is cyano; R3 is methyl; X and Y are each oxygen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE B6

[0107] Table B6 provides 352 compounds of formula (Ia) wherein R1 is ethyl; R2 is hydrogen; R3 is methyl; X and Y are each oxygen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE B7

[0108] Table B7 provides 352 compounds of formula (Ia) wherein R1 is ethyl; R2 is fluoro; R3 is methyl; X and Y are each oxygen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE B8

[0109] Table B8 provides 352 compounds of formula (Ia) wherein R1 is ethyl; R2 is chloro; R3 is methyl; X and Y are each oxygen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE B9

[0110] Table B9 provides 352 compounds of formula (Ia) wherein R1 is ethyl; R2 is bromo;

[0111] R3 is methyl; X and Y are each oxygen; n is 0; and the values of R1 match those of the correspondingly numbered compounds of Table A1.

TABLE B10

[0112] Table B10 provides 352 compounds of formula (Ia) wherein R1 is ethyl; R2 is cyano; R3 is methyl; X and Y are each oxygen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE B11

[0113] Table B11 provides 352 compounds of formula (Ia) wherein R1 is methyl; R2 is hydrogen; R3 is methyl; X is oxygen; Y is sulphur, n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE B12

[0114] Table B12 provides 352 compounds of formula (Ia) wherein R1 is methyl; R2 is fluoro; R3 is methyl; X is oxygen; Y is sulphur, n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE B13

[0115] Table B13 provides 352 compounds of formula (Ia) wherein R1 is methyl; R2 is chloro; R3 is methyl; X is oxygen; Y is sulphur, n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE B14

[0116] Table B 14 provides 352 compounds of formula (Ia) wherein R1 is methyl; R2 is bromo; R3 is methyl; X is oxygen; Y is sulphur; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE B15

[0117] Table B15 provides 352 compounds of formula (Ia) wherein R1 is methyl; R2 is cyano; R3 is methyl; X is oxygen; Y is sulphur; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE B16

[0118] Table B16 provides 352 compounds of formula (Ia) wherein R1 is ethyl; R2 is hydrogen; R3 is methyl; X is oxygen; Y is sulphur; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE B17

[0119] Table B 17 provides 352 compounds of formula (Ia) wherein R1 is ethyl; R2 is fluoro; is R3 is methyl; X is oxygen; Y is sulphur; n is 0; apd the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE B18

[0120] Table B18 provides 352 compounds of formula (Ia) wherein R1 is ethyl; R2 is chloro; R3 is methyl; X is oxygen; Y is sulphur; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE B19

[0121] Table B19 provides 352 compounds of formula (Ia) wherein R1 is ethyl; R2 is bromo; R3 is methyl; X is oxygen; Y is sulphur, n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE B20

[0122] Table B20 provides 352 compounds of formula (Ia) wherein R1 is ethyl; R2 is cyano; R3 is methyl; X is oxygen; Y is sulphur, n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE B21

[0123] Table B21 provides 352 compounds of formula (Ib) wherein R1 is methyl; R2 is hydrogen; R3 is methyl; X and Y are each oxygen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE B22

[0124] Table B22 provides 352 compounds of formula (Ib) wherein R1 is methyl; R2 is fluoro; R3 is methyl; X and Y are each oxygen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE B23

[0125] Table B23 provides 352 compounds of formula (Ib) wherein R1 is methyl; R2 is chloro; R3 is methyl; X and Y are each oxygen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE B24

[0126] Table B24 provides 352 compounds of formula (Ib) wherein R1 is methyl; Re is bromo; R3 is methyl; X and Y are each oxygen; n is 0; and the values of R4 match those of is the correspondingly numbered compounds of Table A1.

TABLE B25

[0127] Table B25 provides 352 compounds of formula (Ib) wherein R1 is methyl; R is cyano; R3 is methyl; X and Y are each oxygen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE B26

[0128] Table B26 provides 352 compounds of formula (Ib) wherein R1 is ethyl; R2 is hydrogen; R3 is methyl; X and Y are each oxygen; n is 0; and tht values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE B27

[0129] Table B27 provides 352 compounds of formula (Ib) wherein R1 is ethyl; 2 is fluoro;

[0130] R3 is methyl; X and Y are each oxygen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE B28

[0131] Table B28 provides 352 compounds of formula P) wherein R1 is ethyl; R2 is chloro; R3 is methyl; X and Y are each oxygen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE B29

[0132] Table B29 provides 352 compounds of formula (Ib) wherein R1 is ethyl; R2 is bromo; R3 is methyl; X and Y are each oxygen; n is 0; and the values of R1 match those of the correspondingly numbered compounds of Table A1.

TABLE B30

[0133] Table B30 provides 352 compounds of formula (Ib) wherein R1 is ethyl; R2 is cyano; R3 is methyl; X and Y are each oxygen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE B31

[0134] Table B31 provides 352 compounds of formula (Ib) wherein R1 is methyl; R2 is hydrogen; R3 is methyl; X is oxygen; Y is sulphur; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE B32

[0135] Table B32 provides 352 compounds of formula (Ib) wherein R1 is methyl; R2 is fluoro; R3 is methyl; X is oxygen; Y is sulphur; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE B33

[0136] Table B33 provides 352 compounds of formula (b) wherein R1 is methyl; R2 is chloro; R3 is methyl; X is oxygen; Y is sulphur, n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE B34

[0137] Table B34 provides 352 compounds of formula (Ib) wherein R1 is methyl; R is bromo; R3 is methyl; X is oxygen; Y is sulphur, n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE B35

[0138] Table B35 provides 352 compounds of formula (Ib) wherein R1 is methyl; R2 is cyano; R3 is methyl; X is oxygen; Y is sulphur, n is 0; and the values of 4 match those of the correspondingly numbered compounds of Table A1.

TABLE B36

[0139] Table B36 provides 352 compounds of formula (Ib) wherein R1 is ethyl; R2 is hydrogen; R3 is methyl; X is oxygen; Y is sulphur; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE B37

[0140] Table B37 provides 352 compounds of formula (Ib) wherein R1 is ethyl; R2 is fluoro; R3 is methyl; X is oxygen; Y is sulphur; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE B38

[0141] Table B338 provides 352 compounds of formula (Ib) wherein R1 is ethyl; R2 is chloro; R3 is methyl; X is oxygen; Y is sulphur; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE B39

[0142] Table B39 provides 352 compounds of formula (Ib) wherein R1 is ethyl; R2 is bromo; R3 is methyl; X is oxygen; Y is sulphur; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE B40

[0143] Table B40 provides 352 compounds of formula (Ib) wherein R1 is ethyl; R2 is cyano; R3 is methyl; X is oxygen; Y is sulphur; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE B41

[0144] Table B41 provides 352 compounds of formula (Ib) wherein R1 is methyl; Rl is hydrogen; Rl is methyl; X is oxygen; Y is NR7; R7 is hydrogen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE B42

[0145] Table B42 provides 352 compounds of formula (Ib) wherein R1 is methyl; R2 is fluoro; R3 is methyl; X is oxygen; Y is NR7; R7 is hydrogen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE B43

[0146] Table B43 provides 352 compounds of formula (Ib) wherein R1 is methyl; R2 is chloro; R3 is methyl; X is oxygen; Y is NR7; R7 is hydrogen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE B44

[0147] Table B44 provides 352 compounds of formula (Ib) wherein R1 is methyl; R2 is bromo; R3 is methyl; X is oxygen; Y is NR7; R7 is hydrogen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE B45

[0148] Table B45 provides 352 compounds of formula (Ib) wherein R1 is methyl; R2 is cyano; R3 is methyl; X is oxygen; Y is NR7; R7 is hydrogen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE B46

[0149] Table B46 provides 352 compounds of formula (Ib) wherein R1 is ethyl; R2 is hydrogen; R3 is methyl; X is oxygen; Y is NR7; R7 is hydrogen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE B47

[0150] Table B47 provides 352 compounds of formula (Ib) wherein R1 is ethyl; R2 is fluoro; R3 is methyl; X is oxygen; Y is NR7; R7 is hydrogen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE B48

[0151] Table B48 provides 352 compounds of formula (Ib) wherein R1 is ethyl; R2 is chloro; R3 is methyl; X is oxygen; Y is NR7; R7 is hydrogen; n is 0; and the values of match those of the correspondingly nwnbered compounds of Table A1.

TABLE B49

[0152] Table B49 provides 352 compounds of formula (Ib) wherein R1 is ethyl; le is bromo; R3 is methyl; X is oxygen; Y is NRl; R7 is hydrogen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE B50

[0153] Table B50 provides 352 compounds of formula (Ib) wherein R1 is ethyl; R2 is cyano; R3 is methyl; X is oxygen; Y is NR7; R7 is hydrogen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE B51

[0154] Table B51 provides 352 compounds of formula (Ib) wherein R1 is methyl; R2 is hydrogen; R3 is methyl; X is oxygen; Y is NR7; R7 is methyl; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE B52

[0155] Table B52 provides 352 compounds of formula (Ib) wherein R1 is methyl; R2 is fluoro; R3 is methyl; X is oxygen; Y is NRC; R7 is methyl; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE B53

[0156] Table B53 provides 352 compounds of formula (Ib) wherein R1 is methyl; R2 is chloro; R3 is methyl; X is oxygen; Y is NR7; R7 is methyl; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE B54

[0157] Table B54 provides 352 compounds of formula (Ib) wherein R1 is methyl; R2 is bromo; R3 is methyl; X is oxygen; Y is NR7; R7 is methyl; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE B55

[0158] Table B55 provides 352 compounds of formula (Ib) wherein R1 is methyl; R2 is cyano; R3 is methyl; X is oxygen; Y is NR7; R7 is methyl; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE B56

[0159] Table B56 provides 352 compounds of formula (Ib) wherein, R1 is ethyl; R2 is hydrogen; R3 is methyl; X is oxygen; Y is NR7; R1 is methyl; n iso; and the values of RW match those of the correspondingly numbered compounds of Table A1.

TABLE B57

[0160] Table B57 provides 352 compounds of formula (Ib) wherein R1 is ethyl; R2 is fluoro; R3 is methyl; X is oxygen; Y is NR7; R7 is methyl; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE B58

[0161] Table B58 provides 352 compounds of formula (Ib) wherein R1 is ethyl; R2 is chloro; R3 is methyl; X is oxygen; Y is NR7; R7 is methyl; n is 0; and the values of RV match those of the correspondingly numbered compounds of Table A1.

TABLE B59

[0162] Table B59 provides 352 compounds of formula (ab) wherein R1 is ethyl; R2 is bromo; R3 is methyl; X is oxygen; Y is NRC; R1 is methyl; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE B60

[0163] Table B60 provides 352 compounds of formula (Ib) wherein R1 is ethyl; R1 is cyano; R3 is methyl; X is oxygen; Y is NR7; R7 is methyl; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE B61

[0164] Table B61 provides 352 compounds of formula (Ia) wherein R1 is methyl; R2 is hydrogen; R3 is methyl; X is oxygen; Y is NR7; R7 is methyl; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE B62

[0165] Table B62 provides 352 compounds of formula (Ia) wherein R1 is methyl; R2 is fluoro; R3 is methyl; X is oxygen; Y is NR7; R7 is methyl; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE B63

[0166] Table B63 provides 352 compounds of formula (Ia) wherein R1 is methyl; R2 is chloro; R3 is methyl; X is oxygen; Y is NR7; R7 is methyl; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE B64

[0167] Table B64 provides 352 compounds of formula (Ia) wherein R1 is methyl; R2 is bromo; R3 is methyl; X is oxygen; Y is NR7; R7 is methyl; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE B65

[0168] Table B65 provides 352 compounds of formula (Ib) wherein R1 is methyl; R2 is cyano; R3 is methyl; X is oxygen; Y is NR7; R7 is methyl; n is 0; and the values of R1 match those of the correspondingly numbered compounds of Table A1.

TABLE B66

[0169] Table B66 provides 352 compounds of formula (Ia) wherein R1 is ethyl; R2 is hydrogen; R3 is methyl; X is oxygen; Y is NR7; R7 is methyl; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE B67

[0170] Table B67 provides 352 compounds of formula (Ia) wherein R1 is ethyl; R2 is fluoro; R3 is methyl; X is oxygen; Y is NR7; R7 is methyl; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE B68

[0171] Table B68 provides 352 compounds of formula (Ia) wherein R1 is ethyl; R2 is chloro; R3 is methyl; X is oxygen; Y is NR7; R7 is methyl; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE B69

[0172] Table B69 provides 352 compounds of formula (Ia) wherein R1 is ethyl; R2 is bromo; R3is methyl; X is oxygen; Y is NR7; R7 is methyl; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE B70

[0173] Table B70 provides 352 compounds of formula (Ia) wherein R1 is ethyl; R2 is cyano; R3 is methyl; X is oxygen; Y is NR7; R7 is methyl; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE C1

[0174] Table C1 provides 352 compounds of formula (Ia) wherein R1 is methyl; R2 is hydrogen; R3 is ethyl; X and Y are each oxygen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE C2

[0175] Table C2 provides 352 compounds of formula (Ia) wherein R1 is methyl; R2 is fluoro; R3 is ethyl; X and Y are each oxygen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE C3

[0176] Table C3 provides 352 compounds of formula (Ia) wherein R1 is methyl; R2 is chloro; R3 is ethyl; X and Y are each oxygen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE C4

[0177] Table C4 provides 352 compounds of formula (Ia) wherein R1 is methyl; R2 is bromo; R3 is ethyl; X and Y are each oxygen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE C5

[0178] Table C5 provides 352 compounds of formula (Ia) wherein R1 is methyl; R2 is cyano; R3 is ethyl; X and Y are each oxygen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE C6

[0179] Table C6 provides 352 compounds of formula (Ia) wherein R1 is ethyl; R2 is hydrogen; R3 is ethyl; X and Y are each oxygen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE C7

[0180] Table C7 provides 352 compounds of formula (Ia) wherein R1 is ethyl; R2 is fluoro; R3 is ethyl; X and Y are each oxygen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE C8

[0181] Table C8 provides 352 compounds of formula (Ia) wherein R1 is ethyl; R2 is chloro; R3 is ethyl; X and Y are each oxygen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE C9

[0182] Table C9 provides 352 compounds of formula (Ia) wherein R1 is ethyl; R2 is bromo; R3 is ethyl; X and Y are each oxygen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE C10

[0183] Table C10 provides 352 compounds of formula (Ia) wherein R1 is ethyl; R2 is cyano; R3 is ethyl; X and Y are each oxygen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLEC11

[0184] Table C11 provides 352 compounds of formula (Ia) wherein R1 is methyl; R2 is hydrogen; R3 is ethyl; X is oxygen; Y is sulphur; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE C12

[0185] Table C12 provides 352 compounds of formula (Ia) wherein R1 is methyl; R2 is fluoro; R3 is ethyl; X is oxygen; Y is sulphur; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE C13

[0186] Table C13 provides 352 compounds of formula (Ia) wherein R1 is methyl; R2 is chloro; R3 is ethyl; X is oxygen; Y is sulphur; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE C14

[0187] Table C14 provides 352 compounds of formula (Ia) wherein R1 is methyl; R2 is bromo; R3 is ethyl; X is oxygen; Y is sulphur; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE C15

[0188] Table C15 provides 352compounds of formula (Ia) wherein R1 is methyl; R2 is cyano; R3 is ethyl; X is oxygen; Y is sulphur; n is 0; and the values of R4 match those of the correspondingly numbered compounds of-Table A1.

TABLE C16

[0189] Table C16 provides 352 compounds of formula (Ia) wherein R1 is ethyl; R2 is hydrogen; R3 is ethyl; X is oxygen; Y is sulphur, n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE C17

[0190] Table C17 provides 352 compounds of formula (Ia) wherein R1 is ethyl; R2 is fluoro; R3 is ethyl; X is oxygen; Y is sulphur, n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE C18

[0191] Table C18 provides 352 compounds of formula (Ia) wherein R1 is ethyl; R2 is chloro; R3 is ethyl; X is oxygen; Y is sulphur, n is 0; and the values of RV match those of the correspondingly numbered compounds of Table A1.

TABLE C19

[0192] Table C19 provides 352 compounds of formula (Ia) wherein R1 is ethyl; R2 is bromo; R3 is ethyl; X is oxygen; Y is sulphur; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE C20

[0193] Table C20 provides 352 compounds of formula (Ia) wherein R1 is ethyl; R2 is cyano; R3 is ethyl; X is oxygen; Y is sulphur; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE C21

[0194] Table C21 provides 352 compounds of formula (Ib) wherein R1 is methyl; R2 is hydrogen; R3 is ethyl; X and Y are each oxygen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE C22

[0195] Table C22 provides 352 compounds of formula (Ib) wherein R1 is methyl; R2 is fluoro; R3 is ethyl; X and Y are each oxygen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE C23

[0196] Table C23 provides 352 compounds of formula (Ib) wherein R1 is methyl; R2 is chloro; R3 is ethyl; X and Y are each oxygen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE C24

[0197] Table C24 provides 352 compounds of formula (Ib) wherein R1 is methyl; R2 is bromo; R3 is ethyl; X and Y are each oxygen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE C25

[0198] Table C25 provides 352 compounds of formula (Ib) wherein R1 is methyl; R2 is cyano; R3 is ethyl; X and Y are each oxygen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE C26

[0199] Table C26 provides 352 compounds of formula (Ib) wherein R1 is ethyl; R2 is hydrogen; R3 is ethyl; X and Y are each oxygen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE C27

[0200] Table C27 provides 352 compounds of formula (Ib) wherein R1 is ethyl; R1 is fluoro; R3 is ethyl; X and Y are each oxygen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE C28

[0201] Table C28 provides 352 compounds of formula (Ib) wherein R1 is ethyl; R2 is chloro; R3 is ethyl; X and Y are each oxygen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE C29

[0202] Table C29 provides 352 compounds of formula (Ib) wherein R1 is ethyl; R2 is bromo; R3 is ethyl; X and Y are each oxygen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE C30

[0203] Table C30 provides 352 compounds of formula (Ib) wherein R1 is ethyl; R2 is cyano; R3 is ethyl; X and Y are each oxygen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE C31

[0204] Table C31 provides 352 compounds of formula (Ib) wherein R1 is methyl; R2 is hydrogen; R3 is ethyl; X is oxygen; Y is sulphur, n is 0; and the values of R4 match those of the correspondingly numbered compounds. of Table A1.

TABLE C32

[0205] Table C32 provides 352 compounds of formula (Ib) wherein R1 is methyl; R2 is fluoro; R3 is ethyl; X is oxygen; Y is sulphur; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE C33

[0206] Table C33 provides 352 compounds of formula (Ib) wherein R1 is methyl; R2 is chloro; R3 is ethyl; X is oxygen; Y is sulphur; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE C34

[0207] Table C34 provides 352 compounds of formula (Ib) wherein R1 is methyl; R2 is bromo; R3 is ethyl; X is oxygen; Y is sulphur; n is0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE C35

[0208] Table C35 provides 352 compounds of formula (Ib) wherein R1 is methyl; R2 is cyano; R3 is ethyl; X is oxygen; Y is sulphur; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE C36

[0209] Table C36 provides 352 compounds of formula (Ib) wherein R1 is ethyl; R2 is hydrogen; R3 is ethyl; X is oxygen; Y is sulphur; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE C37

[0210] Table C37 provides 352 compounds of formula (Ib) wherein R1 is ethyl; R2 is fluoro; R 3 is ethyl; X is oxygen; Y is sulphur, n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE C38

[0211] Table C38 provides 352 compounds of formula (Ib) wherein R1 is ethyl; R2 is chloro; R3 is ethyl; X is oxygen; Y is sulphur; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE C39

[0212] Table C39 provides 352 compounds of formula (Ib) wherein R1 is ethyl; R isbromo; R3 is ethyl; X is oxygen; Y is sulphur, n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE C40

[0213] Table C40 provides 352 compounds of formula (b) wherein R1 is ethyl; R2 is cyano; R3 is ethyl; X is oxygen; Y is sulphur; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE C41

[0214] Table C41 provides 352 compounds of formula (Ib) wherein R1 is methyl; R2 is hydrogen; R3 is ethyl; X is oxygen; Y is NR7; R7 is hydrogen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE C42

[0215] Table C42 provides 352 compounds of formula (ab) wherein R1 is methyl; R2 is fluoro; R3 is ethyl; X is oxygen; Y is NR7; R7 is hydrogen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE C43

[0216] Table C43 provides 352 compounds of formula (Ib) wherein R1 is methyl; R2 is chloro; R3 is ethyl; X is oxygen; Y is NR7; R7 is hydrogen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE C44

[0217] Table C44 provides 352 compounds of formula (Ib) wherein R1 is methyl; R2 is bromo; R3 is ethyl; X is oxygen; Y is NR7; R7 is hydrogen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE C45

[0218] Table C45 provides 352 compounds of formula (Ib) wherein R1 is methyl; R2is cyano; R3 is ethyl; X is oxygen; Y is NR7; R7 is hydrogen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLEC46

[0219] Table C46 provides 352 compounds of formula (Ib) wherein R1 is ethyl; R2 is hydrogen; R3 is ethyl; X is oxygen; Y is NR7; R7 is hydrogen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE C47

[0220] Table C47 provides 352 compounds of formula (Ib) wherein R1 is ethyl; R2 is fluoro; R3 is ethyl; X is oxygen; Y is NR7; R7 is hydrogen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE C48

[0221] Table C48 provides 352 compounds of formula (Ib) wherein R1 is ethyl; R2 is chloro; R3 is ethyl; X is oxygen; Y is NR7; R7 is hydrogen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE C49

[0222] Table C49 provides 352 compounds of formula (Ib) wherein R1 is ethyl; R2 is bromo; R3 is ethyl; X is oxygen; Y is NR7; R7 is hydrogen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE C50

[0223] Table C50 provides 352 compounds of formula (Ib) wherein R1 is ethyl; R2 is cyano; R3 is ethyl; X is oxygen; Y is NR7; R1 is hydrogen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE C51

[0224] Table C51 provides 352 compounds of formula (Ib) wherein R1 is methyl; R2 is hydrogen; R3 is ethyl; X is oxygen; Y is NR7; R7 is methyl; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE C52

[0225] Table C52 provides 352 compounds of formula (Ib) wherein R1 is methyl; R2 is fluoro; R3 is ethyl; X is oxygen; Y is NR7; R7 is methyl; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE C53

[0226] Table C53 provides 352 compounds of formula (Ib) wherein R1 is methyl; R2 is chloro; R3 is ethyl; X is oxygen; Y is NR7; R7 is methyl; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE C54

[0227] Table C54 provides 352 compounds of formula (Ib) wherein R1 is methyl; R2 is bromo; R3 is ethyl; X is oxygen; Y is NR7; R7 is methyl; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE C55

[0228] Table C55 provides 352 compounds of formula (Ib) wherein R1 is methyl; R2 is cyano; R3 is ethyl; X is oxygen; Y is NR7; R7 is methyl; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE C56

[0229] Table C56 provides 352 compounds of formula (Ib) wherein R1 is ethyl; R2 is hydrogen; R3 is ethyl; X is oxygen; Y is NR7; R7 is methyl; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE C57

[0230] Table C57 provides 352 compounds of formula (Ib) wherein R1 is ethyl; R2 is fluoro; R3 is ethyl; X is oxygen; Y is NR7; R7 is methyl; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE C58

[0231] Table C58 provides 352 compounds of formula (Ib) wherein R1 is ethyl; R2 is chloro; R3 is ethyl; X is oxygen; Y is NR7; R7 is methyl; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE C59

[0232] Table C59 provides 352 compounds of formula (b) wherein R1 is ethyl; R2 is bromo; R3 is ethyl; X is oxygen; Y is NR7; R7 is methyl; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE C60

[0233] Table C60 provides 352 compounds of formula (Ib) wherein R1 is ethyl; R2 is cyano; R3 is ethyl; X is oxygen; Y is NR7; R7 is methyl; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE-C61

[0234] Table C61 provides 352 compounds of formula (Ia) wherein R1 is methyl; R2 is hydrogen; R3 is ethyl; X is oxygen; Y is NR7; R7 is methyl; n is 6; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE C62

[0235] Table C62 provides 352 compounds of formula (Ia) wherein R1 is methyl; R2 is fluoro; R3 is ethyl; X is oxygen; Y is NR7; R7 is methyl; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE C63

[0236] Table C63 provides 352 compounds of formula (Ia) wherein R1 is methyl; R2 is chloro; R3 is ethyl; X is oxygen; Y is NR7; R7 is methyl; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE C64

[0237] Table C64 provides 3 52 compounds of formula (Ia) wherein R1 is methyl; R1 is bromo; R1 is ethyl; X is oxygen; Y is NR7; R7 is methyl; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE C65

[0238] Table C65 provides 3 52 compounds of formula (Ib) wherein R1 is methyl; R2 is cyano; R3 is ethyl; X is oxygen; Y is NR7; R7 is methyl; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE C66

[0239] Table C66 provides 352 compounds of formula (Ia) wherein R1 is ethyl; le is hydrogen; le is ethyl; X is oxygen;r Y is NR7; R7 is methyl; n is 0; and the values of R4match those of the correspondingly numbered compounds of Table A1.

TABLE C67

[0240] Table C67 provides 3 52 compounds of formula (Ia) wherein R1 is ethyl; R1 is fluoro; R1 is ethyl; is oxygen; Y is NRC; R7 is methyl; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE C68

[0241] Table C68 provides 352 compounds of formula (Ia) wherein R1 is ethyl; R2 is chloro; R3 is ethyl; X is oxygen; Y is NR7; R7 is methyl; n is 0; and the values of le match those of the correspondingly numbered compounds of Table A1.

TABLE C69

[0242] Table C69 provides 3 52 compounds of formula (Ia) wherein R1 is ethyl; R2 is bromo; R3is ethyl; X is oxygen; Y is NR7; R7 is methyl; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE C70

[0243] Table C70 provides 352 compounds of formula (Ia) wherein R1 is ethyl; R2 is cyano; R3is ethyl; X is oxygen; Y is NW7; R7 is methyl; n is 0;, and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE D1

[0244] Table D1 provides 352 compounds of formula (Ia) wherein R1 is methyl; R2 is hydrogen; R3 is CH2CH2CH3; X and Y are each oxygen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE D2

[0245] Table D2 provides 352 compounds of formula (Ia) wherein R1 is methyl; R2 is fluoro; R3 is CH2CH2CH3; X and Y are each oxygen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE D3

[0246] Table D3 provides 352 compounds of formula (Ia) wherein R1 is methyl; R2 is chloro; R3 is CH2CH2CH3; X and Y are each oxygen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE D4

[0247] Table D4 provides 352 compounds of formula (Ia) wherein R1 is methyl; R2 is bromo; R3 is CH2CH2CH3; X and Y are each oxygen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE D5

[0248] Table D5 provides 352 compounds of formula (Ia) wherein R1 is methyl; R2 is cyano; R3 is CH2CH2CH3; X and Y are each oxygen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE D6

[0249] Table D6 provides 352 compounds of formula (Ia) wherein R1 is ethyl; R2 is hydrogen; R3 is CH2CH2CH3; X and Y are each oxygen; n is 0;, and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE D7

[0250] Table D7 provides 352 compounds of formula (Ia) wherein R1 is ethyl; R2 is fluoro; R3 is CH2CH2CH3; X and Y are each oxygen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE D8

[0251] Table D8 provides 352 compounds of formula (Ia) wherein R1 is ethyl; R2 is chloro; R3 is CH2CH2CH3; X and Y are each oxygen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE D9

[0252] Table D9 provides 352 compounds of formula (Ia) wherein R1 is ethyl; R2 is bromo; R3 is CH2CH2CH3; X and Y are each oxygen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE D10

[0253] Table D10 provides 352 compounds of formula (Ia) wherein R1 is ethyl; R2 is cyano; R3 is CH2CH2CH3; X and Y are each oxygen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLED11

[0254] Table D11 provides 352 compounds of formula (Ia) wherein R1 is methyl; R2 is hydrogen; R3 is CH2CH2CH3; X is oxygen; Y is sulphur; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE D12

[0255] Table D12 provides 352 compounds of formula (Ia) wherein R1 is methyl; R2 is is fluoro; R3 is CH2CH2CH3; X is oxygen; Y is sulphur; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE D13

[0256] Table D13 provides 352 compounds of formula (Ia) wherein R1 is methyl; R2 is chloro; R3 is CH2CH2CH3; X is oxygen; Y is sulphur, n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE D14

[0257] Table D14 provides 352 compounds of formula (Ia) wherein R1 is methyl; R2 is bromo; R3 is CH2CH2CH3; X is oxygen; Y is sulphur, n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE D15

[0258] Table DI5 provides 352 compounds of formula (Ia) wherein R1 is methyl; W is cyano; R3 is CH2CH2CH3; X is oxygen; Y is sulphur; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE D16

[0259] Table D16 provides 352 compounds of formula (Ia) wherein R1 is ethyl; R2 is hydrogen; R3 is CH2CH2CH3; X is oxygen; Y is sulphur; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE D17

[0260] Table D17 provides 352 compounds of formula (Ia) wherein R1 is ethyl; R2 is fluoro; R3 is CH2CH2CH3; X is oxygen; Y is sulphur; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE D18

[0261] Table Dl g provides 352 compounds of formula (Ia) wherein R1 is ethyl; R2 is chloro; R3 is CH2CH2CH3; X is oxygen; Y is sulphur; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE D19

[0262] Table D19 provides 352 compounds of formula (a) wherein R1 is ethyl; R2 is bromo; R3 is CH2CH2CH3; X is oxygen; Y is sulphur; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE D20

[0263] Table D20 provides 352 compounds of formula (Ia) wherein R1 is ethyl; R2 is cyano; R3 is CH2CH2CH3; X is oxygen; Y is sulphur; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE D21

[0264] Table D21 provides 352 compounds of formula (b) wherein R1 is methyl; R2 is hydrogen; R3 is CH2CH2CH3; X and Y are each oxygen; n is (Y, and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE D22

[0265] Table D22 provides 352 compounds of formula (Ib) wherein R1 is methyl; R2 is fluoro; R3 is CH2CH2CH3; X and Y are each oxygen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE D23

[0266] Table D23 provides 352 compounds of formula (Ib) wherein R1 is methyl; R2 is chloro; R3 is CH2CH2CH3; X and Y are each oxygen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE D24

[0267] Table D24 provides 352 compounds of formula (Ib) wherein R1 is methyl; R2 is bromo; R3 is CH2CH2CH3; X and Y are each oxygen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE D25

[0268] Table D25 provides 352 compounds of formula (Ib) wherein R1 is methyl; R2 is cyano; R3 is CH2CH2CH3; X and Y are each oxygen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE D26

[0269] Table D26 provides 352 compounds of formula (b) wherein R1 is ethyl; R2 is hydrogen; R3 is CH2CH2CH3; X and Y are each oxygen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE D27

[0270] Table D27 provides 352 compounds of formula (Ib) wherein R1 is ethyl; R2 is fluoro; R3 is CH2CH2CH3; X and Y are each oxygen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE D28

[0271] Table D28 provides 352 compounds of formula (Ib) wherein R1 is ethyl; R2 is chloro; R3 is CH2CH2CH3; X and Y are each oxygen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE D29

[0272] Table D29 provides 352 compounds of formula (Ib) wherein R1 is ethyl; R2 is bromo; R3 is CH2CH2CH3; X and Y are each oxygen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE D30

[0273] Table D30 provides 352 compounds of formula (Ib) wherein R1 is ethyl; R2 is cyano; R3 is CH2CH2CH3; X and Y are each oxygen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE D31

[0274] Table D31 provides 352 compounds of formula (Ib) wherein R1 is methyl; R2 is hydrogen; R3 is CH2CH2CH3; X is oxygen; Y is sulphur; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE D32

[0275] Table D32 provides 352 compounds of formula (Ib) wherein RX is methyl; R2 is fluoro; R3 is CH2CH2CH3; X is oxygen; Y is sulphur, n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE D33

[0276] Table D33 provides 352 compounds of formula (Ib) wherein R1 is methyl; R2 is chloro; R3 is CH2CH2CH3; X is oxygen; Y is sulphur, n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE D34

[0277] Table D34 provides 352 compounds of formula (Ib) wherein R1 is methyl; R2 is bromo; R3 is CH2CH2CH3; X is oxygen; Y is sulphur; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE D35

[0278] Table D35 provides 352 compounds of formula (Ib) wherein R1 is methyl; R2 is cyano; R3 is CH2CH2CH3; X is oxygen; Y is sulphur; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE1 D36

[0279] Table D36 provides 352 compounds of formula (Ib) wherein R1 is ethyl; R2 is hydrogen; R3 is CH2CH2CH3; X is oxygen; Y is sulphur, n is 0, and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE D37

[0280] Table D37 provides 352 compounds of formula (Ib) wherein R1 is ethyl; R2 is fluoro; R3 is CH2CH2CH3; X is oxygen; Y is sulphur, n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE D38

[0281] Table D38 provides 352 compounds of formula (Ib) wherein R1 is ethyl; R2 is chloro; R3 is CH2CH2CH3; X is oxygen; Y is sulphur, n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE D39

[0282] Table D39 provides 352 compounds of formula (Ib) wherein R1 is ethyl; R2 is bromo; R3 is CH2CH2CH3; X is oxygen; Y is sulphur; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE D40

[0283] Table D40 provides 352 compounds of formula (Ib) wherein R1 is ethyl; R2 is cyano; R3 is CH2CH2CH3; X is oxygen; Y is sulphur; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE D41

[0284] Table D41 provides 352 compounds of formula (Ib) wherein R1 is methyl; R2 is hydrogen; R3 is CH2CH2CH3; X is oxygen; Y is NR7; R7 is hydrogen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE D42

[0285] Table D42 provides 352 compounds of formula (Ib) wherein R1 is methyl; R2 is fluoro; R3 is CH2CH,.CH3; X is oxygen; Y is NR7; R7 is hydrogen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE D43

[0286] Table D43 provides 352 compounds of formula (Ib) wherein R1 is methyl; R2 is chloro; R3 is CH2C2H; X is oxygen Y is NR7; R7 is hydrogen; n is 0; and the values of IV match those of the correspondingly numbered compounds of Table A1.

[0287] Table D44 provides 352 compounds of formula (Ib) wherein R1 is methyl; W is bromo; R3 is CH2CH2CH3; X is oxygen; Y is NR7; R7 is hydrogen; n is 0; and the values of match those of the correspondingly numbered compounds of Table A1.

TABLE D45

[0288] Table D45 provides 352 compounds of formula (Ib) wherein R1 is methyl; R2 is cyano; R3 is CH2CH2CH3; X is oxygen; Y is NR7; R7 is hydrogen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE D46

[0289] Table D46 provides 352 compounds of formula (Ib) wherein R1 is ethyl; R2 is hydrogen; R3 is CH2CH2CH3; X is oxygen; Y is NR7; R7 is hydrogen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE D47

[0290] Table D47 provides 352 compounds of formula (Ib) wherein R1 is ethyl; R2 is fluoro; R3 is CH2CH2CH3; X is oxygen; Y is NR7; R7 is hydrogen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE D48

[0291] Table D48 provides 352 compounds of formula (Ib) wherein R1 is ethyl; R2 is chloro; R3 is CH2CH2CH3; X is oxygen; Y is NR7; R7 is hydrogen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE D49

[0292] Table D49 provides 352 compounds of formula (Ib) wherein R1 is ethyl; R2 is bromo; R3 is CH2CH2CH3; X is oxygen; Y is NR7; R7 is hydrogen; n is 0; and the values of R4 match 1s those of the correspondingly numbered compounds of Table A1.

TABLE D50

[0293] Table D50 provides 352 compounds of formula (Ib) wherein R1 is ethyl; R2 is cyano; R3 is CH2CH2CH3; X is oxygen; Y is NR7; R7 is hydrogen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE D51

[0294] Table D51 provides 352 compounds of formula (Ib) wherein R1 is methyl; R2 is hydrogen; R3 is CH2CH2CH3; X is oxygen; Y is NR7; R7 is methyl; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE D52

[0295] Table D52 provides 352 compounds of formula (Ib) wherein R1 is methyl; R2 is fluoro; R3 is CH2CH2CH3; X is oxygen; Y is NR7; R7 is methyl; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE D53

[0296] Table D53 provides 352 compounds of formula (Ib) wherein R1 is methyl; R2 is chloro; R3 is CH2CH2CH3; X is oxygen; Y is NR7; R7 is methyl; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE D54

[0297] Table D54 provides 352 compounds of formula (Ib) wherein R1 is methyl; R2 is bromo; R3 is CH2CH2CH3; X is oxygen; Y is NR7; R1 is methyl; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE D55

[0298] Table D55 provides 352 compounds of formula (Ib) wherein R1 is methyl; R2 is cyano; R3 is CH2CH2CH3; X is oxygen; Y is NR7; R7 is methyl; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE D56

[0299] Table D56 provides 352 compounds of formula (Ib) wherein R1 is ethyl; R2 is hydrogen; R3 is CH2CH2CH3; X is oxygen; Y is NR7; R7is methyl; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE D57

[0300] Table D57 provides 352 compounds of formula (Ib) wherein R1 is ethyl; R2 is fluoro; R3 is CH2CH2CH3; X is oxygen; Y is NR7; R7 is methyl; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE D58

[0301] Table D58 provides 352 compounds of formula (Ib) wherein R1 is ethyl; R2 is chloro;

[0302] R3 is CH2CH2CH3; X is oxygen; Y is NR7; R7 is methyl; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE D59

[0303] Table D59 provides 352 compounds of formula (Ib) wherein R! is ethyl; R2 is bromo;

[0304] R3 is CH2CH2CH3; X is oxygen; Y is NR7; R7 is methyl; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE D60

[0305] Table D60 provides 352 compounds of formula (b) wherein R1 is ethyl; l2 is cyano;

[0306] R3 is CH2CH2CH3; X is oxygen; Y is NR7; R7 is methyl; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE D61

[0307] Table D61 provides 352 compounds of formula (Ia) wherein R1 is methyl; R2 is hydrogen; R3 is CH2CH2CH3; X is oxygen; Y is NRC; R7 is methyl; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE D62

[0308] Table D62 provides 352 compounds of formula (Ia) wherein R1 is methyl; R2 is fluoro; R3 is CH2CH2CH3; X is oxygen; Y is NR7; R7 is methyl; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE D63

[0309] Table D63 provides 352 compounds of formula (Ia) wherein R1 is methyl; R2 is chloro; R3 is CH2CH2CH3; X is oxygen; Y is NR7; R1 is methyl; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE D64

[0310] Table D64 provides 352 compounds of formula (Ia) wherein R1 is methyl; R2 is bromo; R3 is CH2CH2CH3; X is oxygen; Y is NR7; k7 is methyl; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE D65

[0311] Table D65 provides 352 compounds of formula (Ib) wherein R1 is methyl; R2 is cyano; R3 is CH2CH2CH3; X is oxygen; Y is NRC; R7 is methyl; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE D66

[0312] Table D66 provides 352 compoundsof formula (Ia) wherein R1 is ethyl; R2 is hydrogen; R3 is CH2CH2CH3; X is oxygen; Y is NR7; R7 is methyl; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE D67

[0313] Table D67 provides 352 compounds of formula (Ia) wherein R1 is ethyl; R2 is fluoro; R3 is CH2CH2CH3; X is oxygen; Y is NR7; R7 is methyl; n is 0; and the values of R1 match those of the correspondingly numbered compounds of Table A1.

TABLE D68

[0314] Table D68 provides 352 compounds of formula (Ia) wherein R1 is ethyl; R2 is chloro; R3 is CH2CH2CH3; X is oxygen; Y is NR7; R7 is methyl; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE D69

[0315] Table D69 provides 352 compounds of formula (Ia) wherein R1 is ethyl; R2 is bromo; R3 is CH2CH2CH3; X is oxygen; Y is NR7; R7 is methyl; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE D70

[0316] Table D70 provides 352 compounds of formula (Ia) wherein R1 is ethyl; R2 is cyano; R3 is CH2CH2CH3; X is oxygen; Y is NR7; R7 is methyl; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLEE1

[0317] Table E1 provides 352 compounds of formula (Ia) wherein R1 is methyl; R2 is hydrogen; R3 is CH2CH—CH2; X and Y are each oxygen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE E2

[0318] Table E2 provides 352 compounds of formula (Ia) wherein R1 is methyl; R2 is fluoro; R3 is CH2CH═CH2; X and Y are each oxygen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE E3

[0319] Table E3 provides 352 compounds of formula (Ia) wherein R1 is methyl; R2 is chloro; R3 is CH2CH═CH2; X and Y are each oxygen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE E4

[0320] Table E4 provides 352 compounds of formula (Ia) wherein R1 is methyl; R2 is bromo; R3 is CH2CH═CH2; X and Y are each oxygen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE E5

[0321] Table ES provides 352 compounds of formula (Ia) wherein R1 is methyl; R2 is cyano; R3 is CH2CH═CH2; X and Y are each oxygen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE E6

[0322] Table E6 provides 352 compounds of formula (Ia) wherein R1 is ethyl; R2 is hydrogen; R3 is CH2CH═CH2; X and Y are each oxygen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE E7

[0323] Table E7 provides 352 compounds of formula (Ia) wherein R1 is ethyl; R2 is fluoro; R3 is CH2CH═CH2; X and Y are each oxygen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE E8

[0324] Table E8 provides 352 compounds of formula (Ia) wherein R1 is ethyl; R2 is chloro; R3 is CH2CH—CH2; X and Y are each oxygen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE E9

[0325] Table E9 provides 352 compounds of formula (Ia) wherein R1 is ethyl; R2 is bromo; R3 is CH2CH═CH2; X and Y are each oxygen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE E10

[0326] Table E10 provides 352 compounds of formula (Ia) wherein R1 is ethyl; R2 is cyano; R3 is CH2CH═CH2; X and Y are each oxygen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE E11

[0327] Table E11 provides 352 compounds of formula (Ia) wherein R1 is methyl; R2 is hydrogen; R3 is CH2CH═CH2; X is oxygen; Y is sulphur, n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE E12

[0328] Table E12 provides 352 compounds of formula (Ia) wherein R1 is methyl; R2 is fluoro; R3 is CH2CH═CH2; X is oxygen; Y is sulphur, n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE E13

[0329] Table E13 provides 352 compounds of formula (Ia) wherein R1 is methyl; R2 is chloro; R3 is CH2CH═CH2; X is oxygen; Y is sulphur, n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE E14

[0330] Table E14 provides 352 compounds of formula (Ia) wherein R1 is methyl; R2 is bromo; R3 is CH2CH═CH2; X is oxygen; Y is sulphur; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE E15

[0331] Table E15 provides 352 compounds of formula (Ia) wherein R1 is methyl; R2 is cyano; R3 is CH2CH═CH2; X is oxygen; Y is sulphur; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE E16

[0332] Table E16 provides 352 compounds of formula (Ia) wherein R1 is ethyl; R2 is hydrogen; R3 is CH2CH═CH2; X is oxygen; Y is sulphur; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE E17

[0333] Table E17 provides 352 compounds of formula (Ia) wherein R1 is ethyl; R2 is fluoro; R3 is CH2CH═CH2; X is oxygen; Y is sulphur; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE E18

[0334] Table E18 provides 352 compounds of formula (Ia) wherein R1 is ethyl; R2 is chloro; R3 is CH2CH═CH2; X is oxygen; Y is sulphur, n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE E19

[0335] Table E19 provides 352 compounds of formula (Ia) wherein R1 is ethyl; R2 is bromo; R3 is CH2CH═CH2; X is oxygen; Y is sulphur, n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE E20

[0336] Table E20 provides 352 compounds of formula (Ia) wherein R1 is ethyl; R2 is cyano; R3 is CH2CH═CH2,; X is oxygen; Y is sulphur, n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE E21

[0337] Table E21 provides 352 compounds of formula (Ib) wherein R1 is methyl; R2 is hydrogen; R3 is CH2CH═CH2; X and Y are each oxygen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE E22

[0338] Table E22 provides 352 compounds of formula (Ib) wherein R1 is methyl; R2 is fluoro; R3 is CH2CH═CH2; X and Y are each oxygen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE E23

[0339] Table E23 provides 352 compounds of formula (Ib) wherein R1 is methyl; R2 is chloro; R3 is CH2CH═CH2; X and Y are each oxygen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE E24

[0340] Table E24 provides 352 compounds of formula (Ib) wherein R1 is methyl; R2 is bromo; R3 is CH2CH—CH2; X and Y are each oxygen; n is 0; and the values of R1 match those of the correspondingly numbered compounds of Table A1.

[0341] Table E25 provides 352 compounds of formula (Ib) wherein R1 is methyl; R2 is cyano; R3 is CH2CH═CH2; X and Y are each oxygen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE E26

[0342] Table E26 provides 352 compounds of formula (Ib) wherein R1 is ethyl; R2 is hydrogen; R3 is CH2CH═CH2; X and Y are each oxygen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE E27

[0343] Table E27 provides 352 compounds of formula (Ib) wherein R1 is ethyl; -R2 is fluoro; R3 is CH2CH═CH2; X and Y are each oxygen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE E28

[0344] Table E28 provides 352 compounds of formula (Ib) wherein R1 is ethyl; R2 is chloro; R3 is CH2CH═CH2; X and Y are each oxygen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE E29

[0345] Table E29 provides 352 compounds of formula (Ib) wherein R1 is ethyl; R2 is bromo; R3 is CH2CH═CH2; X and Y are each oxygen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE E30

[0346] Table E30 provides 352 compounds of formula (Ib) wherein R1 is ethyl; R2 is cyano; R3 is CH2CH═CH2; X and Y are each oxygen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE E31

[0347] Table E31 provides 352 compounds of formula (Ib) wherein R1 is methyl; R2 is hydrogen; R3 is CH2CH═CH2; X is oxygen; Y is sulphur; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE E32

[0348] Table E32 provides 352 compounds of formula (Ib) wherein R1 is methyl; R2 is fluoro; R3 is CH2CH═CH2; X is oxygen; Y is sulphur; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE E33

[0349] Table E33 provides 352 compounds of formula (Ib) wherein R1 is methyl; R2 is chloro; R3 is CH2CH═CH2; X is oxygen; Y is sulphur; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE E34

[0350] Table E34 provides 352 compounds of formula (Ib) wherein R1 is methyl; R2 is bromo; R3 is CH2CH═CH2; X is oxygen; Y is sulphur; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE E35

[0351] Table E35 provides 352 compounds of formula (Ib) wherein R1 is methyl; R2 is cyano; R3 is CH2CH═CH2; X is oxygen; Y is sulphur, n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE E36

[0352] Table E36 provides 352 compounds of formula (Ib) wherein R1 is ethyl; R2 is hydrogen; R3 is CH2CH═CH2; X is oxygen; Y is sulphur; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE E37

[0353] Table E37 provides 352 compounds of formula (Ib) wherein R1 is ethyl; R2 is fluoro; R3 is CH2CH═CH2; X is oxygen; Y is sulphur; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE E38

[0354] Table E38 provides 352 compounds of formula (Ib) wherein R1 is ethyl; R2 is chloro; R3 is CH2CH═CH2; X is oxygen; Y is sulphur; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE E39

[0355] Table E39 provides 352 compounds of formula (Ib) wherein R1 is ethyl; R2 is bromo; R3 is CH2CH═CH2; X is oxygen; Y is sulphur; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE E40

[0356] Table E40 provides 352 compounds of formula (Ib) wherein R1 is ethyl; R2 is cyano; R3 is CH2CH═CH2; X is oxygen; Y is sulphur, n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE 41

[0357] Table E41 provides 352 compounds of formula (Ib) wherein R1 is methyl; R2is hydrogen; R3 is CH2CH═CH2; X is oxygen; Y is NR7; R7 is hydrogen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE E42

[0358] Table E42 provides 352 compounds of formula (Ib) wherein R1 is methyl; R2 is fluoro; R3 is CH2CH═CH2; X is oxygen; Y is NR7; R7 is hydrogen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE E43

[0359] Table E43 provides 352 compounds of formula (Ib) wherein R1 is methyl; R2 is chloro; R3 is CH2CH═CH2; X is oxygen; Y is NR7; R7 is hydrogen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE E44

[0360] Table E44 provides 352 compounds of formula (Ib) wherein R1 is methyl; R2 is bromo; R3 is CH2CH═CH2; X is oxygen; Y is NR7; R7 is hydrogen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE E45

[0361] Table E45 provides 352 compounds of formula (Ib) wherein R1 is methyl; R2 is cyano; R3 is CH2CH═CH2; X is oxygen; Y is NR7; R7 is hydrogen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE E46

[0362] Table E46 provides 352 compounds of formula (Ib) wherein R1 is ethyl; R2 is hydrogen; R3 is CH2CH═CH2; X is oxygen; Y is NR7; R7 is hydrogen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE F47

[0363] Table E47 provides 352 compounds of formula (Ib) wherein R1 is ethyl; R2 is fluoro; R3 is CH2CH═CH2; X is oxygen; Y is NR7; R7 is hydrogen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE E48

[0364] Table E48 provides 352 compounds of formula (Ib) wherein R1 is-ethyl; R2 is chloro; R3 is CH2CH═CH2; X is oxygen; Y is NR7; R7 is hydrogen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE 49

[0365] Table E49 provides 352 compounds of formula (Ib) wherein R1 is ethyl; R2 is bromo; R3 is CH2CH═CH2; X is oxygen; Y is NR7; 7 is hydrogen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE E50

[0366] Table E50 provides 352 compounds of formula (Ib) wherein R1 is ethyl; R2 is cyano; R3 is CH2CH═CH2; X is oxygen; Y is NR!; R7 is hydrogen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE E51

[0367] Table E51 provides 352 compounds of formula (Ib) wherein R1 is methyl; R2 is hydrogen; R3 is CH2CH═CH2; X is oxygen; Y is NR7; R7 is methyl; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE E52

[0368] Table E52 provides 352 compounds of formula (Ib) wherein R1 is methyl; R2 is fluoro; R3 is CH2CH═CH2; X is oxygen; Y is NR7; R7 is methyl; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE E53

[0369] Table E53 provides 352 compounds of formula (Ib) wherein R1 is methyl; R2 is chloro; R3 is CH2CH═CH2; X is oxygen; Y is NR7; R7 is methyl; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE E54

[0370] Table E54 provides 352 compounds of formula (Ib) wherein R1 is methyl; R2 is bromo; R3 is CH2CH═CH2; X is oxygen; Y is NR7; R7 is methyl; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE E55

[0371] Table E55 provides 352 compounds of formula (Ib) wherein R1 is methyl; R2 is cyano; R3 is CH2CH═CH2; X is oxygen; Y is NR7; R7 is methyl; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE E56

[0372] Table E56 provides 352 compounds of formula (Ib) wherein R1 is ethyl; R2 is hydrogen; R3 is CH2CH═CH2; X is oxygen; Y is NR7; R7 is methyl; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE E57

[0373] Table E57 provides 352 compounds of formula (Ib) wherein R1 is ethyl; R2 is fluoro;

[0374] R3 is CH2CH═CH2; X is oxygen; Y is NR7; R7 is methyl; n is 0; and the values of-R match those of the correspondingly numbered compounds of Table A1.

TABLE E58

[0375] Table E58 provides 352 compounds of formula (Ib) wherein R1 is ethyl; R2 is chloro; R3 is CH2CH═CH2; X is oxygen; Y is NR7; R7 is methyl; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE E59

[0376] Table E59 provides 352 compounds of formula (ab) wherein R1 is ethyl; R2 is bromo; R3 is CH2CH═CH2; X is oxygen; Y is NR7; R7 is methyl; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE E60

[0377] Table E60 provides 352 compounds of formula (Ib) wherein R1 is ethyl; R2 is cyano; R3 is CH2CH═CH2; X is oxygen; Y is NR7; R7 is methyl; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE E61

[0378] Table E61 provides 352 compounds of formula (Ia) wherein R1 is methyl; R2 is hydrogen; R3 is CH2CH═CH2; X is oxygen; Y is NR7; R7 is methyl; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE E62

[0379] Table E62 provides 352 compounds of formula (Ia) wherein R1 is methyl; R2 is fluoro; R3 is CH2CH═CH2; X is oxygen; Y is NR7; R7 is methyl; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE E63

[0380] Table E63 provides 352 compounds of formula (Ia) wherein R1 is methyl; R2 is chloro; R3 is CH2CH═CH2; X is oxygen; Y is NR7; R7 is methyl; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE E64

[0381] Table E64 provides 352 compounds of formula (Ia) wherein R1 is methyl; R2 is bromo; R3 is CH2CH═CH2; X is oxygen; Y is NR7; R7 is methyl; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE E65

[0382] Table E65 provides 352 compounds of formula (Ib) wherein R1 is methyl; R2 is cyano; R3 is CH2CH═CH2; X is oxygen; Y is NR7; R7 is methyl; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE E66

[0383] Table E66 provides 352 compounds of formula (Ia) wherein R1 is ethyl; R2 is hydrogen; R3 is CH2CH═CH2; X is oxygen; Y is NR7; R7 is methyl; n is 0; and the values of RW match those of the correspondingly numbered compounds of Table A1.

TABLE E67

[0384] Table E67 provides 352 compounds of formula (Ia) wherein R1 is ethyl; R2 is fluoro; R3 is CH2CH═CH2; X is oxygen; Y is NR7; R7 is methyl; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE E68

[0385] Table E68 provides 352 compounds of formula (Ia) wherein R1 is ethyl; R2 is chloro; R3 is CH2CH═CH2; X is oxygen; Y is NR7; R7 is methyl; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE E69

[0386] Table E69 provides 352 compounds of formula (Ia) wherein R1 is ethyl; R2 is bromo; R3 is CH2CH═CH2; X is oxygen; Y is NR7; R7 is methyl; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE E70

[0387] Table E70 provides 352 compounds of formula (Ia) wherein R1 is ethyl; R2 is cyano; R3 is CH2CH═CH2; X is oxygen; Y is NR7; R7 is methyl; n is 0; and the values of R4 match hose of the correspondingly numbered compounds of Table A1.

TABLE F1

[0388] Table F1 provides 352 compounds of formula (Ia) wherein R1 is methyl; R2 is hydrogen; R3 is CH2C.CH; X and Y are each oxygen, n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE F2

[0389] Table F2 provides 352 compounds of formula (Ia) wherein R1 is methyl; R2 is fluoro; R3 is CH2C.CH; X and Y are each oxygen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE F3

[0390] Table F3 provides 352 compounds of formula (Ia) wherein R1 is methyl; R2 is chloro; R3 is CH2C.CH; X and Y are each oxygen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE F4

[0391] Table F4 provides 352 compounds of formula (Ia) wherein R1 is methyl; R2 is bromo; R3 is CH2C.CH; X and Y are each oxygen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE F5

[0392] Table F5 provides 352 compounds of formula (Ia) wherein R1 is methyl; R2 is cyano; R3 is CH2C.CH; X and Y are each oxygen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE F6

[0393] Table F6 provides 352 compounds of formula (Ia) wherein R1 is ethyl; R2 is hydrogen; R3 is CH2C.CH; X and Y are each oxygen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE F7

[0394] Table F7 provides 352 compounds of formula (Ia) wherein R1 is ethyl; R2 is fluoro; R3 is CH2C.CH; X and Y are each oxygen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE F8

[0395] Table F8 provides 352 compounds of formula (Ia) wherein R1 is ethyl; R2 is chloro; is CH2C.CH; X and Y are each oxygen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE F9

[0396] Table F9 provides 352 compounds of formula (Ia) wherein RV is ethyl; R2 is chloro; R3 is CH2C.CH; X and Y are each oxygen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE F10

[0397] Table F10 provides 352 compounds of formula (Ia) wherein R1 is ethyl; R2 is cyano; R3 is CH2C.CH; X and Y are each oxygen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE F11

[0398] Table F11 provides 352 compounds of formula (Ia) wherein R1 is methyl; R2 is hydrogen; R3 is CH2C.CH; X is oxygen; Y is sulphur; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE F12

[0399] Table F12 provides 352 compounds of formula (Ia) wherein R1 is methyl; R2 is fluoro; R3 is CH2C.CH; X is oxygen; Y is sulphur; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE F13

[0400] Table F13 provides 352 compounds of formula (Ia) wherein R1 is methyl; R2 is chloro; R3 is CH2C.CH; X is oxygen; Y is sulphur, n is 0; and the values of Ra match those of the correspondingly numbered compounds of Table A1.

TABLE F14

[0401] Table F14 provides 352 compounds of formula (Ia) wherein R1 is methyl; R2 is bromo; R3 is CH2C.CH; X is oxygen; Y is sulphur; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE F15

[0402] Table F15 provides 352 compounds of formula (Ia) wherein R1 is methyl; R2 is cyano; R3 is CH2C.CH; X is oxygen; Y is sulphur, n is 0, and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE F16

[0403] Table F16 provides 352 compounds of formula (Ia) wherein R1 is ethyl; R2 is hydrogen; R3 is CH2C.CH; X is oxygen; Y is sulphur, n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE F17

[0404] Table F17 provides 352 compounds of formula (Ia) wherein R1 is ethyl; R2 is fluoro; R3 is CH2C.CH; X is oxygen; Y is sulphur, n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE F18

[0405] Table F18 provides 352 compounds of formula (Ia) wherein R1 is ethyl; R2 is chloro; R3 is CH2C.CH; X is oxygen; Y is sulphur; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE F19

[0406] Table F19 provides 352 compounds of formula (Ia) wherein R1 is ethyl; R2 is bromo; R3 is CH2C.CH; X is oxygen; Y is sulphur; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE F20

[0407] Table F20 provides 352 compounds of formula (Ia) wherein R1 is ethyl; R2 is cyano; R3 is CH2C.CH; X is oxygen; Y is sulphur; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE F21

[0408] Table F21 provides 352 compounds of formula (Ib) wherein R1 is methyl; R2 is hydrogen; R3 is CH2C.CH; X and Y are each oxygen; n is 0; and the values of 4 match those of the correspondingly numbered compounds of Table A1.

TABLE F22

[0409] Table F22 provides 352 compounds of formula (Ib) wherein R1 is methyl; R2 is is fluoro; R3 is CH2C.CH; X and Y are each oxygen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE F23

[0410] Table F23 provides 352 compounds of formula (Ib) wherein R1 is methyl; R2 is chloro; R3 is CH2C.CH; X and Y are each oxygen, n is 0; and the values of R4 match-those of the correspondingly numbered compounds of Table A1.

TABLE F24

[0411] Table F24 provides 352 compounds formula (Ib) wherein R1 is methyl; R2 is bromo; R3 is CH2C.CH; X and Y are each oxygen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE F25

[0412] Table F25 provides 352 compounds of formula (Ib) wherein R1 is methyl; R2 is cyano; R3 is CH2C.CH; X and Y are each oxygen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE F26

[0413] Table F26 provides 352 compounds of formula (Ib) wherein R1 is ethyl; R2 is hydrogen; R3 is CH2C.CH; X and Y are each oxygen; n is 0; and the values of R1 match those of the correspondingly numbered compounds of Table A1.

TABLE F27

[0414] Table F27 provides 352 compounds of formula (Ib) wherein R1 is ethyl; R2 is fluoro; R3 is CH2C.CH; X and Y are each oxygen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE F28

[0415] Table F28 provides 352 compounds of formula (Ib) wherein R1 is ethyl; R2 is chloro; R3 is CH2C.CH; X and Y are each oxygen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE F29

[0416] Table F29 provides 352 compounds of formula (Ib) wherein R1 is ethyl; R2 is bromo; R3 is CH2C.CH; X and Y are each oxygen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE F30

[0417] Table F30 provides 352 compounds of formula (Ib) wherein R1 is ethyl; R2 is cyano; R3 is CH2C.CH; X and Y are each oxygen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE F31

[0418] Table F31 provides 352 compounds of formula (Ib) wherein R1 is methyl; R2 is hydrogen; R3 is CH2C.CH; X is oxygen; Y is sulphur n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE F32

[0419] Table F32 provides 352 compounds of formula (Ib) wherein R1 is methyl; R2 is fluoro; R3 is CH2C.CH; X is oxygen; Y is sulphur; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE F33

[0420] Table F33 provides 352 compounds of formula (b) wherein R1 is methyl; R2 is chloro; R3 is CH2C.CH; X is oxygen; Y is sulphur, n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE F34

[0421] Table F34 provides 352 compounds of formula (Ib) wherein R1 is methyl; R2 is bromo; R3 is CH2C.CH; X is oxygen; Y is sulphur; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE F35

[0422] Table F35 provides 352 compounds of formula (Ib) wherein R1 is methyl; R2 is cyano; R3 is CH2C.CH; X is oxygen; Y is sulphur; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE F36

[0423] Table F36 provides 352 compounds of formula (Ib) wherein R1 is ethyl; R2 is hydrogen; R3 is CH2C.CH; X is oxygen; Y is sulphur; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE F37

[0424] Table F37 provides 352 compounds of formula (Ib) wherein R1 is ethyl; R2 is fluoro; R3 is CH2C.CH; X is oxygen; Y is sulphur, n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE F38

[0425] Table F38 provides 352 compounds of formula (Ib) wherein R1 is ethyl; R2 is chloro; R3 is CH2C.CH; X is oxygen; Y is sulphur, n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE F39

[0426] Table F39 provides 352 compounds of formula (Ib) wherein R1 is ethyl; R2 is bromo; R3 is CH2C.CH; X is oxygen; Y is sulphur, n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE F40

[0427] Table F40 provides 352 compounds of formula (Ib) wherein R1 is ethyl; R2 is cyano; R3 is CH2C.CH; X is oxygen; Y is sulphur, n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE F41

[0428] Table F41 provides 352 compounds of formula (Ib) wherein R1 is methyl; R2 is hydrogen; R3 is CH2C.CH; X is oxygen; Y is NR7; R7 is hydrogen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE F42

[0429] Table F42 provides 352 compounds of formula (Ib) wherein R1 is methyl; R2 is fluoro; R3 is CH2C.CH; X is oxygen; Y is NR7; R7 is hydrogen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE F43

[0430] Table F43 provides 352 compounds of formula (Ib) wherein R1 is methyl; R2 is chloro; R3 is CH2C.CH; X is oxygen; Y is NR7; R7 is hydrogen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE F44

[0431] Table F44 provides 352 compounds of formula (Ib) wherein R1 is methyl; R2 is bromo; R3 is CH2C.CH; X is oxygen; Y is NR7; R7 is hydrogen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE F45

[0432] Table F45 provides 352 compounds of formula (Ib) wherein R1 is methyl; 2is cyano; R3 is CH2C.CH; X is oxygen; Y is NR7; R7 is hydrogen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE F46

[0433] Table F46 provides 352 compounds of formula (Ib) wherein R1 is ethyl; R2 is hydrogen; R3 is CH2C.CH; X is oxygen; Y is NR7; R7 is hydrogen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE F47

[0434] Table F47 provides 352 compounds of formula (Ib) wherein R1 is ethyl; R2 is fluoro; R3 is CH2C.CH; X is oxygen; Y is NR7; R7 is hydrogen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE F48

[0435] Table F48 provides 352 compounds of formula (Ib) wherein R1 is ethyl, R2 is chloro; R3 is CH.C.CH; Xis oxygen; Y is NR7; EC is hydrogen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE F49

[0436] Table F49 provides 352 compounds of formula (Ib) wherein R1 is ethyl; R2 is bromo; R3 is CH2C.CH; X is oxygen; Y is NR7; R1 is hydrogen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE F50

[0437] Table F50 provides 352 compounds of formula (Ib) wherein R1 is ethyl; R2 is cyano;

[0438] R3 is CH2C.CH; X is oxygen; Y is NR7; R7 is hydrogen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE F51

[0439] Table F51 provides 352 compounds of formula (Ib) wherein R1 is methyl; R2 is hydrogen; R3 is CH2C.CH; X is oxygen; Y is NR7; R7 is methyl; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE F52

[0440] Table F52 provides 352 compounds of formula (Ib) wherein R! is methyl; R2 is fluoro; R3 is CH2C.CH; X is oxygen; Y is NR1; R7 is methyl; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE F53

[0441] Table F53 provides 352 compounds formula (Ib) wherein R1 is methyl, R2 is chloro; R3 is CH2C.CH; X is oxygen; Y is NR7; R1 is methyl; n is 0; and the values of R4 match those of the correspondingly nuinbered compounds of Table A1.

TABLE F54

[0442] Table F54 provides 352 compounds of formula (Ib) wherein R1 is methyl, R2 is bromo; R3 is CH2C.CH; X is oxygen; Y is NR7; R7 is methyl; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE F55

[0443] Table F55 provides 352 compounds of formula (Ib) wherein R1 is methyl; R2 is cyano; R3 is CH2C.CH; X is oxygen; Y is NR7; R7 is methyl; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE F56

[0444] Table F56 provides 352 compounds of formula (Ib) wherein R1 is ethyl; R2 is hydrogen; R3 is CH2C.CH; X is oxygen; Y is NR7; R7 is methyl; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE F57

[0445] Table F57 provides 352 compounds of formula (Ib) wherein R1 is ethyl; R2 is fluoro; R3 is CH2C.CH; X is oxygen; Y is NR7; R7 is methyl; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE F58

[0446] Table F58 provides 352 compounds of formula (Ib) wherein R1 is ethyl; R2 is chloro; R3 is CH2C.CH; X isoxygen; Y is NR7; R7 is methyl; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE F59

[0447] Table F59 provides 352 compounds of formula (Ib) wherein R1 is ethyl; R2 is bromo; R3 is CH2C.CH; X is oxygen; Y is NR7; R7 is methyl; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE F60

[0448] Table F60 provides 352 compounds of formula (Ib) wherein R1 is ethyl; R2 is cyano; R3 is CH2C.CH; X is oxygen; Y is NRC; R7 is methyl; n is 0; and Mhe values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE F61

[0449] Table F61 provides 352 compounds of formula (Ia) wherein R1 is methyl; R2 is hydrogen; R3 is CH2C.CH; X is oxygen; Y is NR7; V is miethyl, n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE F62

[0450] Table F62 provides 352 compounds of formula (Ia) wherein R1 is methyl; R2 is fluoro; R3 is CH2C.CH; X is oxygen; Y is NR7; R7 is methyl; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE F63

[0451] Table F63 provides 352 compounds of formula (Ia) wherein R1 is methyl; R2 is chloro; R3 is CH2C.CH; X is oxygen, Y is NR7; R7 is methyl; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE F64

[0452] Table F64 provides 352 compounds of formula (Ia) wherein R1 is methyl; R2 is bromo; R3 is CH2C.CH; X is oxygen; Y is NR7; R7 is methyl; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE F65

[0453] Table F65 provides 352 compounds of formula (Ib) wherein R1 is methyl; R2 is cyano; R3 is CH2C.CH; X is oxygen; Y is NR7; R7 is methyl; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE F66

[0454] Table F66 provides 352 compounds of formula (Ia) wherein R1 is ethyl; R2 is hydrogen; R3 is CH2C.CH; X is oxygen; Y is NR7; R7 is methyl; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE F67

[0455] Table F67 provides 352 compounds of formula (Ia) wherein R1 is ethyl; R2 is fluoro; R3 is CH2C.CH; X is oxygen; Y is NR7; R7 is methyl; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE F68

[0456] Table F68 provides 352 compounds of formula (Ia) wherein R1 is ethyl; R2 is chloro; R3 is CH2C.CH; X is oxygen; Y is NR7; R7 is methyl; n is 0; and the valuesofR4 match hose of the correspondingly nunbered compounds of Table A1.

TABLE F69

[0457] Table F69 provides 352 compounds of formula (Ia) wherein R1 is ethyl; R2 is bromo; R3 is CH2C.CH; X is oxygen; Y is NR7; R7 is methyl; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE F70

[0458] Table F70 provides 352 compounds of formula (Ia) wherein R1 is ethyl;R2 is cyano; R3 is CH2C.CH; X is oxygen; Y is NR7; R7 is methyl; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE G1

[0459] Table G1 provides 352 compounds of formula (Ia) wherein R1 is methyl; R2 is hydrogen; R3 is CH2CN; X and Y are each oxygen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE G2

[0460] Table G2 provides 352 compounds of formula (Ia) wherein R1 is methyl; R? is fluoro; R3 is CH2CN; X and Y are each oxygen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE G3

[0461] Table G3 provides 352 compounds of formula (Ia) wherein R1 is methyl; R2 is chloro; R3 is CH2CN; X and Y are each oxygen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE G4

[0462] Table G4 provides 352 compounds of formula (Ia) wherein R1 is methyl; R2 is bromo; R3 is CH2CN; X and Y are each oxygen; n is 0; and the values of R match those of the correspondingly numbered compounds of Table A1.

TABLE G5

[0463] Table G5 provides 352 compounds of formula (Ia) wherein R1 is methyl; R2 is cyano; R3 is CH2CN; X and Y are each oxygen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE G6

[0464] Table G6 provides 352 compounds of formula (Ia) wherein R1 is ethyl; R2 is hydrogen; R3 is CH2CN; X and Y are each oxygen; n is 0; and the values of ie match those of the correspondingly numbered compounds of Table A1.

TABLE G7

[0465] Table G7 provides 352 compounds of formula (Ia) wherein R1 is ethyl; 2 is fluoro; R3 is CH2CN; X and Y are each oxygen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE G8

[0466] Table G8 provides 352 compounds of formula (Ia) wherein R1 is ethyl; R2 is chloro; R3 is CH2CN; X and Y are each oxygen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE G9

[0467] Table G9 provides 352 compounds of formula (Ia) wherein R1 is ethyl; R2 is bromo. R3 is CH2CN; X and Y are each oxygen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE G10

[0468] Table G10 provides 352 compounds of formula (Ia) wherein R1 is ethyl; R2 is cyano; R3 is CH2CN; X and Y are each oxygen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE G11

[0469] Table G11 provides 352 compounds of formula (Ia) wherein R1 is methyl; R2 is hydrogen; R3 is CH2CN; X is oxygen; Y is sulphur, n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE G12

[0470] Table G12 provides 352 compounds of formula (Ia) wherein R1 is methyl; R2 is fluoro; R3 is CH2CN; X is oxygen; Y is sulphur; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE G13

[0471] Table G13 provides 352 compounds of formula (Ia) wherein R1 is methyl; R2 is chloro; R3 is CH2CN; X is oxygen; Y is sulphur; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE G14

[0472] Table G14 provides 352 compounds of formula (Ia) wherein R1 is methyl; R2 is bromo; R3 is CH2CN; X is oxygen; Y is sulphur, n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE G15

[0473] Table G15 provides 352 compounds of formula (Ia) wherein R1 is methyl; R2 is cyano; R3 is CH2CN; X is oxygen; Y is sulphur; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE G16

[0474] Table G16 provides 352 compounds of formula (Ia) wherein R1 is ethyl; R2 is hydrogen; R3 is CH2CN; X is oxygen; Y is sulphur; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE G17

[0475] Table G17 provides 352 compounds of formula (Ia) wherein R1 is ethyl; R2 is fluoro; R3 is CH2CN; X is oxygen; Y is sulphur; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE G18

[0476] Table G18 provides 352 compounds of formula (Ia) wherein R1 is ethyl; R2 is chloro; R3 is CH2CN; X is oxygen; Y is sulphur; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE G19

[0477] Table G19 provides 352 compounds of formula (Ia) wherein R1 is ethyl; R2 is bromo;

[0478] R3 is CH2CN; X is oxygen; Y is sulphur, n is 0; and the values of 4 match those of the correspondingly numbered compounds of Table A1.

TABLE G20

[0479] Table G20 provides 352 compounds of formula (Ia) wherein R1 is ethyl; R? is cyano;

[0480] R3 is CH2CN; X is oxygen; Y is sulphur, n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE G21

[0481] Table G21 provides 352 compounds of formula (Ib) wherein R1 is methyl; R2 is hydrogen; R3 is CH2CN; X and Y are each oxygen; n is 0; and the-values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE G22

[0482] Table G22 provides 352 compounds of formula (Ib) wherein R1 is methyl; R2 is fluoro; R3 is CH2CN; X and Y are each oxygen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE G23

[0483] Table G23 provides 352 compounds of formula (Ib) wherein R1 is methyl; R2 is chloro; R3 is CH2CN; X and Y are each oxygen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE G24

[0484] Table G24 provides 352 compounds of formula (Ib) wherein R1 is methyl; R2 is bromo; R3 is CH2CN; X and Y are each oxygen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE G25

[0485] Table G25 provides 352 compounds of formula (Ib) wherein R1 is methyl; R2 is cyano; R3 is CH2CN; X and Y are each oxygen; n is 0; and the values of RV match those of the correspondingly numbered compounds of Table A1.

TABLE G26

[0486] Table G26 provides 352 compounds of formula (Ib) wherein R1 is ethyl; R2 is hydrogen; R3 is CH2CN; X and Y are each oxygen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE G27

[0487] Table G27 provides 352 compounds of formula (Ib) wherein R1 is ethyl; R2 is fluoro; R3 is CH2CN; X and Y are each oxygen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE G28

[0488] Table G28 provides 352 compounds of formula (Ib) wherein R1 is ethyl; R2 is chloro; R3 is CH2CN; X and Y are each oxygen; n is 0; and the values of R4 match those of the correspondingly numbered compound of Table A1.

TABLE G29

[0489] Table G29 provides 352 compoundsofformula (Ib) wherein R1 is ethyl; R2 is bromo; R3 is CH2CN; X and Y are each oxygen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE G30

[0490] Table G30 provides 352 compounds of formula (Ib) wherein R1 is ethyl; R2 is cyano; R3 is CH2CN; X and Y are each oxygen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE G31

[0491] Table G3 1 provides 352 compounds of formula (1b) wherein R1 is methyl; R2 is hydrogen; R3 is CH2CN; X is oxygen; Y is sulphur; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE G32

[0492] Table G32 provides 352 compounds of formula (Ib) wherein R1 is methyl; R2 is fluoro; R3 is CH2CN; X is oxygen; Y is sulphur, n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE G33

[0493] Table G33 provides 352 compounds of formula (Ib) wherein R1 is methyl; R2 is chloro; R3 is CH2CN; X is oxygen; Y is sulphur; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE G34

[0494] Table G34 provides 352 compounds of formula (Ib) wherein R1 is methyl; R2 is bromo; R3 is CH2CN; X is oxygen; Y is sulphur; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE G=35

[0495] Table G35 provides 352 compounds of formula (Ib) wherein R1 is methyl; R2 is cyano; R3 is CH2CN; X is oxygen; Y is sulphur, n is 0; and the values of R4=match those of the correspondingly numbered compounds of Table A1.

TABLE G33

[0496] Table G36 provides 352 compounds of formula (Ib) wherein R1 is ethyl; R2 is hydrogen; R3 is CH2CN; X is oxygen; Y is sulphur, n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE G37

[0497] Table G37 provides 352 compounds of formula (Ib) wherein R1 is ethyl; R2 is fluoro; R3 is CH2CN; X is oxygen; Y is sulphur, n is 0; and the values of Rl match those of the correspondingly numbered compounds of Table A1.

TABLE G38

[0498] Table G38 provides 352 compounds of formula (Ib) wherein R1 is ethyl; R2 is chloro; R3 is CH2CN; X is oxygen; Y is sulphur, n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE G39

[0499] Table G39 provides 352 compounds of formula (Ib) wherein R1 is ethyl; R2 is bromo; R3 is CH2CN; X is oxygen; Y is sulphur; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE G40

[0500] Table G40 provides 352 compounds of formula (Ib) wherein R1 is ethyl; R2 is cyano; R3 is CH2CN; X is oxygen; Y is sulphur; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE G41

[0501] Table G41 provides 352 compounds of formula (Ib) wherein R1 is methyl; R2 is hydrogen; R3 is CH2CN; X is oxygen; Y is NR7; R7 is hydrogen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE G42

[0502] Table G42 provides 352 compounds of formula (ab) wherein R1 is methyl; R2 is fluoro; R3 is CH2CN; X is oxygen; Y is NR7; R7 is hydrogen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE G43

[0503] Table G43 provides 352 compounds of formula (Ib) wherein R1 is methyl; R2 is chloro; R3 is CH2CN;X is oxygen; Y is NR7;R7 is hydrogen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE G44

[0504] Table G44 provides 352 compounds of formula (Ib) wherein R1 is methyl; R2 is bromo; R3 is CH2CN; X is oxygen; Y is NR7;R7 is hydrogen; n is 0, and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE G45

[0505] Table G45 provides 352 compounds of formula (Ib) wherein R1 is methyl; R2 is cyano; R3 is CH2CN; X is oxygen; Y is NR7; R7 is hydrogen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE G46

[0506] Table G46 provides 352 compounds of formula (Ib) wherein R1 is ethyl; R2 is hydrogen; R3 is CH2CN; X is oxygen; Y is NR7; R7 is hydrogen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE G47

[0507] Table G47 provides 352 compounds of formula (Ib) wherein R1 is ethyl; R2 is fluoro; R3 is CH2CN; X is oxygen; Y is NR7; R7 is hydrogen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE G48

[0508] Table G48 provides 352 compounds of formula (Ib) wherein R1 is ethyl; R2 is chloro; R3 is CH2CN; X is oxygen; Y is NR7; R7 is hydrogen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE G49

[0509] Table G49 provides 352 compounds of formula (Ib) wherein R1 is ethyl; R2 is bromo; R3 is CH2CN; X is oxygen; Y is NR7; R7 is hydrogen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE G50

[0510] Table G50 provides 352 compounds of formula (Ib) wherein R1 is ethyl; R2 is cyano; R3 is CH2CN; X is oxygen; Y is NR7; R7 is hydrogen; nis 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE G51

[0511] Table G51 provides 352 compounds of formula (Ib) wherein R1 is methyl; R2 is hydrogen; R3 is CH2CN; X is oxygen; Y is NR7; R7 is methyl; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE G52

[0512] Table G52 provides 352 compounds of formula (Ib) wherein R1 is methyl; R2 is fluoro; R3 is CH2CN; X is oxygen; Y is NR7; R7 is methyl; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE G53

[0513] Table G53 provides 352 compounds of formula (b) wherein R1 is methyl; R2 is chloro; R3 is CH2CN; X is oxygen; Y is NR7; R7 is methyl; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE G54

[0514] Table G54 provides 352 compounds of formula (Ib) wherein R1 is methyl; R2 is bromo; R3 is CH2CN; X is oxygen; Y is NR7; R7 is methyl; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE G55

[0515] Table G55 provides 352 compounds of formula (Ib) wherein R1 is methyl; R2 is cyano; R3 is CH2CN; X is oxygen; Y is NR7; R1 is methyl; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE G56

[0516] Table 056 provides 352 compounds of formula (Ib) wherein R1 is ethyl; R2 is hydrogen; R3 is CH2CN; X is oxygen; Y is NR7; R7 is methyl; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE G57

[0517] Table G57 provides 352 compounds of formula (Ib) wherein R1 is ethyl; R2 is fluoro; R3 is CH2CN; X is oxygen; Y is NR7; R7 is methyl; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE G58

[0518] Table G58 provides 352 compounds of formula (Ib) wherein R1 is ethyl; R2 is chloro; R3 is CH2CN; X is oxygen; Y is NR7; R7 is methyl; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE G59

[0519] Table G59 provides 352 compounds of formula (Ib) wherein R1 is ethyl; R2 is bromo; R3 is CH2CN; X is oxygen; Y is NR7; R7 is methyl; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE G60

[0520] Table G60 provides 352 compounds of formula (Ib) wherein R1 is ethyl; R2 is cyano; R3 is CH2CN; X is oxygen; Y is NR7; R7 is methyl; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE G61

[0521] Table G61 provides 352 compounds of formula (Ia) wherein R1 is methyl; R2 is hydrogen; R3 is CH2CN; X is oxygen; Y is NR7; R7 is methyl; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE G62

[0522] Table G62 provides 352 compounds of formula (Oa) wherein R1 is methyl; R2 is fluoro; R3 is CH2CN; X is oxygen; Y is NR7; R7 is methyl; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE G63

[0523] Table G63 provides 352 compounds of formula (Ia) wherein R1 is methyl; R2 is chloro; R3 is CH2CN; X is oxygen; Y is NR7; R7 is methyl; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE G64

[0524] Table G64 provides 352 compounds of formula (Ia) wherein R1 is methyl; R2 is bromo; R3 is CH2CN; X is oxygen; Y is NR7; R7 is methyl; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE G65

[0525] Table G65 provides 352 compounds of formula (Ib) wherein R1 is methyl; R2 is cyano; R3 is CH2CN; X is oxygen; Y is NRI; R7 is methyl; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE G66

[0526] Table G66 provides 352 compounds of formula (Ia) wherein R1 is ethyl; R2 is hydrogen; R3 is CH2CN; X is oxygen; Y is NR7; R7 is methyl; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE G67

[0527] Table G67 provides 352 compounds of formula (Ia) wherein R1 is ethyl, R2 is fluoro; R3 is CH2CN; X is oxygen; Y is NR7; R7 is methyl; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE G68

[0528] Table G68 provides 352 compounds of formula (Ia) wherein R1 is ethyl; R2 is chloro; R3 is CH2CN; X is oxygen; Y is NR7; R7 is methyl; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE G69

[0529] Table G69 provides 352 compounds of formula (Ia) wherein R1 is ethyl; R2 is bromo; R3 is CH2CN; X is oxygen; Y is NR7; R7 is methyl; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE G70

[0530] Table G70 provides 352 compounds of formula (Ia) wherein R1 is ethyl; R2 is cyano; R3 is CH2CN; X is oxygen; Y is NR7; R7 is methyl; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE H1

[0531] Table H1 provides 352 compounds of formula (Ia) wherein R1 is methyl; R2 is hydrogen; R3 is CH2CF3; X and Y are each oxygen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE H2

[0532] Table H2 provides 352 compounds of formula (Ia) wherein R1 is methyl; R2 is fluoro; R3 is CH2CF3; X and Y are each oxygen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE H3

[0533] Table H3 provides 352 compounds of formula (Ia) wherein R1 is methyl; R2 is chloro; R3 is CH2CF3; X and Y are each oxygen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE H4

[0534] Table H4 provides 352 compounds of formula (Ia) wherein R1 is methyl; R2 is bromo; R3 is CH2CF3; X and Y are each oxygen; n is 0; and the values of match those of the correspondingly numbered compounds of Table A1.

TABLE H5

[0535] Table H5 provides 352 compounds of formula (Ia) wherein R1 is methyl; R2 is cyano; R3 is CH2CF3; X and Y are each oxygen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE H6

[0536] Table H6 provides 352 compounds of formula (Ia) wherein R1 is ethyl; R2 is hydrogen; R3 is CH2CF3; X and Y are each oxygen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE H7

[0537] Table H7 provides 352 compounds of formula (Ia) wherein R1 is ethyl; R2 is fluoro; R3 is CH2CF3; X and Y are each oxygen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE H8

[0538] Table H8 provides 352 compounds of formula (Ia) wherein R1 is ethyl; R2 is chloro; R3 is CH2CF3; X and Y are each oxygen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE H9

[0539] Table H9 provides 352 compounds of formula (Ia) wherein R1 is ethyl; R2 is bromo; R3 is CH2CF3; X and Y are each oxygen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE H10

[0540] Table H10 provides 352 compounds of formula (Ia) wherein R1 is ethyl; R2 is cyano; R3 is CH2CF3; X and Y are each oxygen; n is 0; and the-values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE H11

[0541] Table H11 provides 352 compounds of formula (Ia) wherein R1 is methyl; R2 is hydrogen; R3 is CH2CF3; X is oxygen; Y is sulphur, n is 0, and the values of R1 match those of the correspondingly numbered compounds of Table A1.

TABLE H12

[0542] Table H12 provides 352 compounds of formula (Ia) wherein R1 is methyl; R2 is fluoro; R3 is CH2CF3; X is oxygen; Y is sulphur, n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE H13

[0543] Table H13 provides 352 compounds of formula (Ia) wherein R1 is methyl; R2 is chloro; R3 is CH2CF.; X is oxygen; Y is sulphur; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE H14

[0544] Table H14 provides 352 compounds of formula (Ia) wherein R1 is methyl; R2 is bromo; R3 is CH2CF3; X is oxygen; Y is sulphur, n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE H15

[0545] Table H15 provides 352 compounds of formula (Ia) wherein R1 is methyl; R2 is cyano; R3 is CH2CF3; X is oxygen; Y is sulphur; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE H16

[0546] Table H16 provides 352 compounds of formula (Ia) wherein R1 is ethyl; R2 is hydrogen; R3 is CH2CF3; X is oxygen; Y is sulphur; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE H17

[0547] Table H17 provides 352 compounds of formula (Ia) wherein R1 is ethyl; R2 is fluoro; is R3 is CH2CF3; X is oxygen; Y is sulphur; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE H18

[0548] Table H18 provides 352 compounds of formula (Ia) wherein R1 is ethyl; R2 is chloro;

[0549] R3 is CH2CF3; X is oxygen; Y is sulphur, n is 0; and the values of RT match those of the correspondingly numbered compounds of Table A1.

TABLE H19

[0550] Table H19 provides 352 compounds of formula (Ia) wherein R1 is ethyl; R2 is bromo; R3 is CH2CF3; X is oxygen; Y is sulphur; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE H20

[0551] Table H20 provides 352 compounds of formula (Ia) wherein R! is ethyl; R2 is cyano;

[0552] R3 is CH2CF3; X is oxygen; Y is sulphur, n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE H21

[0553] Table H21 provides 352 compounds of formula (Ib) wherein R1 is methyl; R2 is hydrogen; R3 is CH2CF3; X and Y are each oxygen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE H22

[0554] Table H22 provides 352 compounds of formula (Ib) wherein R1 is methyl; R2 is fluoro; R3 is CH2CF3; X and Y are each oxygen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE H23

[0555] Table H23 provides 352 compounds of formula (Ib) wherein R1 is methyl; R1 is chloro; R3 is CH2CF3; X and Y are each oxygen; n is 0; and the values of RV match those of the correspondingly numbered compounds of Table A1.

TABLE H24

[0556] Table H24 provides 352 compounds of formula (Ib) wherein R1 is methyl; R2 is bromo; R3 is CH2CF3; X and Y are each oxygen; n is 0; and the values of 4 match those of the correspondingly numbered compounds of Table A1.

TABLE H25

[0557] Table H125 provides 352 compounds of formula (Ib) wherein R1 is methyl; R2 is cyano; R3 is CH2CF3; X and Y are each oxygen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1,

TABLE H26

[0558] Table H26 provides 352 compounds of formula (Ib) wherein R1 is ethyl; R2 is hydrogen; R3 is CH2CF3; X and Y are each oxygen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE H27

[0559] Table H27 provides 352 compounds of formula (Ib) wherein R1 is ethyl; R2 is fluoro; R3 is CH2CF3; X and Y are each oxygen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE 1128

[0560] Table H28 provides 352 compounds of formula (Ib) wherein R1 is ethyl; R2 is chloro; R3 is CH2CF3; X and Y are each oxygen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE H29

[0561] Table H29 provides 352 compounds of formula (Ib) wherein R1 is ethyl; R2 is bromo; R3 is CH2CF3; X and Y are each oxygen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE H30

[0562] Table H30 provides 352 compounds of formula (Ib) wherein R1 is ethyl; R2 is cyano; R3 is CH2CF3; X and Y are each oxygen; n is 0, and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE H31

[0563] Table H31 provides 352 compounds of formula (Ib) wherein R1 is methyl; R2 is hydrogen; R3 is CH2CF3; X is oxygen; Y is sulphur, n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE H32

[0564] Table H32 provides 352 compounds of formula (Ib) wherein R1 is methyl; R2 is fluoro; R3 is CH2CF3; X is oxygen; Y is sulphur; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE H33

[0565] Table H33 provides 352 compounds of formula (Ib) wherein R1 is methyl; R2 is chloro; R3 is CH2CF3; X is oxygen; Y is sulphur, n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE H34

[0566] Table H34 provides 352 compounds of formula (Ib) wherein R1 is methyl; R2 is bromo; R3 is CH2CF3; X is oxygen; Y is sulphur, n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE H35

[0567] Table H35 provides 352 compounds of formula (Ib) wherein R1 is methyl; R2 is cyano; le is CH2CF3; X is oxygen; Y is sulphur, n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE H36

[0568] Table H36 provides 352 compounds of formula (Ib) wherein R1 is ethyl; R2 is hydrogen; R3 is CH2CF3; X is oxygen; Y is sulphur; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE H37

[0569] Table H37 provides 352 compounds of formula (Ib) wherein R1 is ethyl; R2 is fluoro; R3 is CH2CF3; X is oxygen; Y is sulphur; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE H38

[0570] Table H38 provides 352 compounds of formula (Ib) wherein R1 is ethyl; R2 is chloro; R3 is CH2CF3; X is oxygen; Y is sulphur, n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE H39

[0571] Table H39 provides 352 compounds of formula (Ib) wherein R1 is ethyl; R2 is bromo; R3 is CH2CF3; X is oxygen; Y is sulphur; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE H40

[0572] Table H40 provides 352 compounds of formula (Ib) wherein R1 is ethyl; R2 is cyano; R3 is CH2CF3; X is oxygen; Y is sulphur; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE H41

[0573] Table H41 provides 352 compounds of formula (Ib) wherein R1 is methyl; R2 is hydrogen; R3 is CH2CF3; X is oxygen; Y is NR7; R7 is hydrogen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE H42

[0574] Table H42 provides 352 compounds of formula (Ib) wherein R1 is methyl; R2 is fluoro; R3 is CH2CF3; X is oxygen; Y is NR7; R7 is hydrogen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE H43

[0575] Table H43 provides 352 compounds of formula (Ib) wherein R1 is methyl; R2 is chloro; R3 is CH2CF3; X is oxygen; Y is NR7; R7 is hydrogen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE H44

[0576] Table H44 provides 352 compounds of formula (Ib) wherein R1 is methyl; R2 is bromo; R3 is CH2CF3; X is oxygen; Y is NR7; R7 is hydrogen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE H45

[0577] Table H45 provides 352 compounds of formula (Ib) wherein R1 is methyl; R2 is cyano; R3 is CH2CF3; X is oxygen; Y is NR7; R7 is hydrogen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE H46

[0578] Table H46 provides 352 compounds of formula (Ib) wherein R1 is ethyl; R2 is hydrogen; R3 is CH2CF3; X is oxygen; Y is NR7; R7 is hydrogen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE H47

[0579] Table H47 provides 352 compounds of formula (Ib) wherein R1 is ethyl; R2 is fluoro; R3 is CH2CF3; X is oxygen; Y is NR7; R7 is hydrogen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE H48

[0580] Table H48 provides 352 compounds of formula (Ib) wherein R1 is ethyl; R2 is chloro; R3 is CH2CF3; X is oxygen; Y is NR7; R7 is hydrogen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE H49

[0581] Table H49 provides 352 compounds of formula (Ib) wherein R1 is ethyl; R2 is bromo; R3 is CH2CF3; X is oxygen; Y is NR7; R7 is hydrogen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE H50

[0582] Table H50 provides 352 compounds of formula (Ib) wherein R1 is ethyl; R2 is cyano; R3 is CH2CF3; X is oxygen; Y is NR7; R7 is hydrogen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE H51

[0583] Table H51 provides 352 compounds of formula (Ib) wherein R1 is methyl; R2 is hydrogen; R3 is CH2CF3; X is oxygen; Y is NR7; R7 is methyl; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE H52

[0584] Table H52 provides 352 compounds of formula (Ib) wherein R1 is methyl; R2 is fluoro; R3 is CH2CF3; X is oxygen; Y is NR7; R7 is methyl; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE H53

[0585] Table H53 provides 352 compounds of formula (Ib) wherein R1 is methyl; R2 is chloro; R3 is CH2CF3; X is oxygen; Y is NR7; R7 is methyl; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE H54

[0586] Table H54 provides 352 compounds of formula (Ib) wherein R1 is methyl; R2 is bromo; R3 is CH2CF3; X is oxygen; Y is NR7; R7 is methyl; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE H55

[0587] Table H55 provides 352 compounds of formula (Ib) wherein R1 is methyl; R2 is cyano; R3 is CH2CF3; X is oxygen; Y is NR7; R7 is methyl; n is 0; and the values of R4 match those of the correspondingly numbered-compounds of Table A1.

TABLE H56

[0588] Table H56 provides 352 compounds of formula (Ib) wherein R1 is ethyl; R2 is hydrogen; R3 is CH2CF3; X is oxygen; Y is NR7; R7 is methyl; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE H57

[0589] Table H57 provides 352 compounds of formula (Ib) wherein R1 is ethyl; R2 is fluoro; R3 is CH2CF3; X is oxygen; Y is NR7; R7 is methyl; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE H58

[0590] Table H58 provides 352 compounds, of formula (Ib) wherein R1 is ethyl; R2 is chloro; R3 is CH2CF3; X is oxygen; Y is NR7; R7 is methyl; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE H59

[0591] Table H59 provides 352 compounds of formula (Ib) wherein R1 is ethyl; R2 is bromo; R3 is CH2CF3; X is oxygen; Y is NR7; R7 is methyl; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE H60

[0592] Table H60 provides 352 compounds of formula (Ib) wherein R1 is ethyl; R2 is cyano; R3 is CH2CF3; X is oxygen; Y is NR7; R7 is methyl; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE H61

[0593] Table H61 provides 352 compounds of formula (Ia) wherein R1 is methyl; R2 is hydrogen; R3 is CH2CF3; X is oxygen; Y is NR7; R7 is methyl; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE H62

[0594] Table H62 provides 352 compounds of formula (Ia) wherein R1 is methyl; R2 is fluoro; R3 is CH2CF3; X is oxygen; Y is NR7; R7 is methyl; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE H63

[0595] Table H63 provides 352 compounds of formula (Ia) wherein R1 is methyl; R2 is chloro; R3 is CH2CF3; X is oxygen; Y is NR7; R7 is methyl; n is 0; and the values of R1 match those of the correspondingly numbered-compounds of Table A1.

TABLE H64

[0596] Table H64 provides 352 compounds of formula (Ia) wherein R1 is methyl; R2 is bromo; R1 is CH2CF3; X is oxygen; Y is NR7; R7 is methyl; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE H65

[0597] Table H65 provides 352 compounds of formula (Ib) wherein R1 is methyl; R2 is cyano; R3 is CH2CF3; X is oxygen; Y is NR7; R7 is methyl; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE H66

[0598] Table H66 provides 352 compounds of formula (Ia) wherein R1 is ethyl; R2 is hydrogen; R3 is CH2CF3; X is oxygen; Y is NR7; R7 is methyl; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE H67

[0599] Table H67 provides 352 compounds of formula (Ia) wherein R1 is ethyl; R2 is fluoro; R3 is CH2CF3; X is oxygen; Y is NR7; R7 is methyl; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE H68

[0600] Table H68 provides 352 compounds of formula (Ia) wherein R1 is ethyl; R2 is chloro; R3 is CH2CF3; X is oxygen; Y is NR7; R7 is methyl; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE H69

[0601] Table H69 provides 352 compounds of formula (Ia) wherein R1 is ethyl; R2 is bromo; R3 is CH2CF3; X is oxygen; Y is NR7; R7 is methyl; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE H70

[0602] Table H70 provides 352 compounds of formula (Ia) wherein R1 is ethyl; R2 is cyano; R3 is CH2CF3; X is oxygen; Y is NRi; R7 is methyl; nis O;and the values t fiR4 match those of the correspondingly numbered compounds of Table A1.

TABLE I1

[0603] Table I1 provides 352 compounds of formula (Ia) wherein R1 is methyl; R2 is hydrogen; R3 is CH2CO2CH3; X and Y are each oxygen; nis 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE I2

[0604] Table I2 provides 352 compounds of formula (Ia) wherein R1 is methyl; R2 is fluoro; R3 is CH2CO2CH3; X and Y are each oxygen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE I3

[0605] Table I3 provides 352 compounds of formula (Ia) wherein R1 is methyl; R2 is chloro; R3 is CH2CO2CH3; X and Y are each oxygen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE I4

[0606] Table I4 provides 352 compounds of formula (Ia) wherein R1 is methyl; R2 is bromo; R3 is CH2CO2CH3; X and Y are each oxygen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE I5

[0607] Table I5 provides 352 compounds of formula (Ia) wherein R1 is methyl; R2 is cyano; R3 is CH2CO2CH3; X and Y are each oxygen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE 16

[0608] Table 16 provides 352 compounds of formula (Ia) wherein R1 is ethyl; R2 is hydrogen;

[0609] R3 is CH2CO2CH3; X and Y are each oxygen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE I7

[0610] Table I7 provides 352 compounds of formula (Ia) wherein R1 is ethyl; R2 is fluoro; R3 is CH2CO2CH3; X and Y are each oxygen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE 18

[0611] Table 18 provides 352 compounds of formula (Ia) wherein R1 is ethyl; R2 is chloro; R3 is CH2CO2CH3; X and Y are each oxygen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE I9

[0612] Table I9 provides 352 compounds of formula (Ia) wherein R1 is ethyl; R2 is bromo; R3 is CH2CO2CH3; X and Y are each oxygen; n is 0; and the values of R1 match those of the correspondingly numbered compounds of Table A1.

TABLE I10

[0613] Table I10 provides 352 compounds of formula (Ia) wherein R1 is ethyl; R2 is cyano;

[0614] R3 is CH2CO2CH3; X and Y are each oxygen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE I11

[0615] Table I11 provides 352 compounds of formula (Ia) wherein R1 is methyl; R2 is hydrogen; R3 is CH2CO2CH3; X is oxygen; Y is sulphur, n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE I12

[0616] Table I12 provides 352 compounds of formula (Ia) wherein R1 is methyl; R2 is fluoro; R3 is CHCO2CH3; X is oxygen; Y is sulphur; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE I13

[0617] Table I13 provides 352 compounds of formula (Ia) wherein R1 is methyl; R2 is chloro; R3 is CH2CO2CH3; X is oxygen; Y is sulphur, n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE I14

[0618] Table I14-provides 352 compounds of formula (Ia) wherein R1 is methyl; R2 is bromo; R3 is CH2CO2CH3; X is oxygen; Y is sulphur, n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE I15

[0619] Table I15 provides 352compounds of formula (Ia) wherein R1 is methyl; R2 is cyano; R3 is CH2CO2CH3; X is oxygen; Y is sulphur; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE I16

[0620] Table I16 provides 352 compounds of formula (Ia) wherein R1 is ethyl; R2 is hydrogen; R3 is CH2CO2CH3; X is oxygen; Y is sulphur, n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE I17

[0621] Table I17 provides 352 compounds of formula (Ia) wherein R1 is ethyl; R2 is fluoro; R3 is CH2CO2CH3; X is oxygen; Y is sulphur, n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE I18

[0622] Table I18 provides 352 compounds of formula (Ia) wherein R1 is ethyl; R2 is chloro; R3 is CH2CO2CH3; X is oxygen; Y is sulphur, n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE I19

[0623] Table I19 provides 352 compounds of formula (Ia) wherein R1 is ethyl; R2 is bromo; R3 is CH2CO2CH3; X is oxygen; Y is sulphur; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE I20

[0624] Table I20 provides 352 compounds of formula (Ia) wherein R1 is ethyl; R2 is cyano; R3 is CH2CO2CH3; X is oxygen; Y is sulphur; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE I21

[0625] Table I21 provides 352 compounds of formula (Ib) wherein R1 is methyl; R2 is hydrogen; R3 is CH2CO2CH3; X and Y are each oxygen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE I22

[0626] Table I22 provides 352 compounds of formula (Ib) wherein R1 is methyl; R2 is fluoro; R3 is CH2CO2CH3; X and Y are each oxygen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE I23

[0627] Table I23 provides 352 compounds of formula (Ib) wherein R1 is methyl; R2 is chloro; R3 is CH2CO2CH3; X and Y are each oxygen; n is 0; and the values of R4 match those of the correspondingly numbered compound of Table A1.

TABLE I24

[0628] Table I24 provides 352 compounds of formula (Ib) wherein R1 is methyl; R2 is bromo; R3 is CH2CO2CH3; X and Y are each oxygen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE I25

[0629] Table I25 provides 352 compounds of formula (Ib) wherein R1 is methyl; R2 is cyano; R3 is CH2CO2CH3; X and Y are each oxygen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE I26

[0630] Table I26 provides 352 compounds of formula (Ib) wherein R1 is ethyl; R2 is hydrogen; R3 is CH2CO2CH3; X and Y are each oxygen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE I27

[0631] Table I27 provides 352 compounds of formula (Ib) wherein R1 is ethyl; R2 is fluoro; R3 is CH2CO2CH3; X and Y are each oxygen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE I28

[0632] Table I28 provides 352 compounds of formula (Ib) wherein R1 is ethyl; R2 is chloro; R3 is CH2CO2CH3; X and Y are each oxygen; n is 0; and the values of R match those of the correspondingly numbered compounds of Table A1.

TABLE I29

[0633] Table I29 provides 352 compounds of formula (Ib) wherein R1 is ethyl; R2 is bromo; R3 is CH2CO2CH3; X and Y are each oxygen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE I30

[0634] Table I30 provides 352 compounds of formula (Ib) wherein R1 is ethyl; R2 is cyano; R3 is CH2CO2CH3; X and Y are each oxygen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE I31

[0635] Table I31 provides 352 compounds of formula (Ib) wherein R1 is methyl; R2 is hydrogen; R3 is CH2CO2CH3; X is oxygen; Y is sulphur, n is 0, and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE I32

[0636] Table I32 provides 352 compounds of formula (Ib) wherein R1 is methyl; R2 is fluoro; R3 is CH2CO2CH3; X is oxygen; Y is sulphur; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE I33

[0637] Table I33 provides 352 compounds of formula (Ib) wherein R1 is methyl; R2 is chloro; R3 is CH2CO2CH3; X is oxygen; Y is sulphur, n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE I34

[0638] Table I34 provides 352 compounds of formula (Ib) wherein R1 is methyl; R2 is bromo; R3 is CH2CO2CH3; X is oxygen; Y is sulphur; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE I35

[0639] Table I35 provides 352 compounds of formula (Ib) wherein R1 is methyl; R2 is cyano; R3 is CH2CO2CH3; X is oxygen; Y is sulphur, n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE I36

[0640] Table I36 provides 352 compounds of formula (Ib) wherein R1 is ethyl; R2 is hydrogen; R3 is CH2CO2CH3; X is oxygen; Y is sulphur; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE I37

[0641] Table I37 provides 352 compounds of formula (Ib) wherein R1 is ethyl; R2 is fluoro; R3 is CH2CO2CH3; X is oxygen; Y is sulphur; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE I38

[0642] Table I38 provides 352 compounds of formula (Ib) wherein R1 is ethyl; R2 is chloro; R3 is CH2CO2CH3; X is oxygen; Y is sulphur, n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE I39

[0643] Table I39 provides 352 compounds of formula (Ib) wherein R1 is ethyl; R2 is bromo; R3 is CH2CO2CH3; X is oxygen; Y is sulphur; n is 0, and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE I40

[0644] Table I40 provides 352 compounds of formula (Ib) wherein R1 is ethyl; R2 is cyano; R3 is CH2CO2CH3; X is oxygen; Y is sulphur, n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE I41

[0645] Table I41 provides 352 compounds of formula (Ib) wherein R1 is methyl; R2 is hydrogen; R3 is CH2CO2CH3; X is oxygen; Y is NR7; R1 is hydrogen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE I42

[0646] Table I42 provides 352 compounds of formula (Ib) wherein R1 is methyl; R2 is fluoro; R3 is CH2CO2CH3; X is oxygen; Y is NR7; R7 is hydrogen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE I43

[0647] Table I43 provides 352 compounds of formula (b) wherein R1 is methyl; R2 is chloro; R3 is CH2CO2CH3; X is oxygen; Y is NR7; R7 is hydrogen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE I44

[0648] Table I44 provides 352 compounds of formula (Ib) wherein R1 is methyl; R2 is bromo; R3 is CH2CO2CH3; X is oxygen; Y is NR7; R7 is hydrogen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE I45

[0649] Table I45 provides 352 compounds of formula (Ib) wherein R1 is methyl; R2 is cyano; R3 is CH2CO2CH3; X is oxygen; Y is NR7; R7 is hydrogen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE I46

[0650] Table I46 provides 352 compounds of formula (Ib) wherein R1 is ethyl; R2 is hydrogen; R3 is CH2CO2CH3; X is oxygen; Y is NR7; R7 is hydrogen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE I47

[0651] Table I47 provides 352 compounds of formula (Ib) wherein R1 is ethyl; R2 is fluoro; R3 is CH2CO2CH3; X is oxygen; Y is NR7; R7 is hydrogen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE I48

[0652] Table I48 provides 352 compounds of formula (Ib) wherein R1 is ethyl; R2 is chloro; R3 is CH2CO2CH3; X is oxygen; Y is NR7; R7 is hydrogen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE I49

[0653] Table I49 provides 352 compounds of formula (Ib) wherein R1 is ethyl; R2 is bromo; R3 is CH2CO2CH3; X is oxygen; Y is NR7; R7 is hydrogen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE I50

[0654] Table I50 provides 352 compounds of formula (Ib) wherein R1 is ethyl; R2 is cyano; R3 is CH2CO2CH3; X is oxygen; Y is NR7; R7 is hydrogen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE I51

[0655] Table I51 provides 352 compounds of formula (Ib) wherein R1 is methyl; R2 is hydrogen; R3 is CH2CO2CH3; X is oxygen; Y is NR7; R7 is methyl; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE I52

[0656] Table I52 provides 352 compounds of formula (Ib) wherein R1 is methyl; R2 is fluoro; R3 is CH2CO2CH3; X is oxygen; Y is NR7; R7 is methyl; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE I53

[0657] Table I53 provides 352 compounds of formula (Ib) wherein R1 is methyl; R2 is chloro; R3 is CH2CO2CH3; X is oxygen; Y is NR7; R7 is methyl; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE I54

[0658] Table I54 provides 352 compounds of formula (Ib) wherein R1 is methyl; R2 is bromo; R3 is CH2CO2CH3; X is oxygen; Y is NR7; R7 is methyl; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE I55

[0659] Table I55 provides 352 compounds of formula (Ib) wherein R7 is methyl; R2 is cyano; R3 is CH2CO2CH3; X is oxygen; Y is NR7; R7 is methyl; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE I56

[0660] Table I56 provides 352 compounds of formula (Ib) wherein R1 is ethyl; R2 is hydrogen; R3 is CH2CO2CH3; X is oxygen; Y is NR7; R7 is methyl; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE I57

[0661] Table I57 provides 352 compounds of formula (Ib) wherein R1 is ethyl; R2 is fluoro; R3 is CH2CO2CH3; X is oxygen; Y is NR7; R4 is methyl; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE I58

[0662] Table I58 provides 352 compounds of formula (Ib) wherein R1 is ethyl; R2 is chloro; R3 is CH2CO2CH3; X is oxygen; Y is NR7; R7 is methyl; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE I59

[0663] Table I59 provides 352 compounds of formula (Ib) wherein R1 is ethyl; R2 is bromo; R3 is CH2CO2CH3; X is oxygen; Y is NR7; R7 is methyl; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE I60

[0664] Table I60 provides 352 compounds of formula (Ib) wherein R1 is ethyl; R2 is cyano; R3 is CH2CO2CH3; X is oxygen; Y is NR7; R7 is methyl; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE I61

[0665] Table I61 provides 352 compounds of formula (Ia) wherein R1 is methyl; R2 is hydrogen; R3 is, CH2CO2CH3; X is oxygen; Y is NR7; R7 is methyl; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE I62

[0666] Table I62 provides 352 compounds of formula (Ia) wherein R1 is methyl; R2 is fluoro; R3 is CH2CO2CH3; X is oxygen; Y is NR7; R7 is methyl; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE I63

[0667] Table I63 provides 352 compounds of formula (Ia) wherein R1 is methyl; R2 is chloro; R3 is CH2CO2CH3; X is oxygen; Y is NR7; R1 is methyl; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE I64

[0668] Table I64 provides 352 compounds of formula (Ia) wherein R1 is methyl; R2 is bromo; R3 is CH2CO2CH3; X is oxygen; Y is NR7; R7 is methyl; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE I65

[0669] Table I65 provides 352 compounds of formula (Ib) wherein R1 is methyl; R2 is cyano; R3 is CH2CO2CH3; X is oxygen; Y is NR7; R7 is methyl; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE I66

[0670] Table I66 provides 352 compounds of formula (Ia) wherein R1 is ethyl; R2 is hydrogen; R3 is CH2CO2CH3; X is oxygen; Y is NR7; R7 is methyl; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE I67

[0671] Table I67 provides 352 compounds of formula (Ia) wherein R1 is ethyl; R2 is fluoro; R3 is CH2CO2CH3; X is oxygen; Y is NR7; R7 is methyl; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE I68

[0672] Table I68 provides 352 compounds of formula (Ia) wherein R1 is ethyl; R2 is chloro; R3 is CH2CO2CH3; X is oxygen; Y is NR7; k7 is methyl; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE I69

[0673] Table I69 provides 352 compounds of formula (Ia) wherein R1 is ethyl; R2 is bromo; R3 is CH2CO2CH3; X is oxygen; Y is NR7; R7 is methyl; n is 0; and the values of RV match those of the correspondingly numbered compounds of Table A1.

TABLE I70

[0674] Table I70 provides 352 compounds of formula (Ia) wherein R1 is ethyl; R2 is cyano; R3 is CH2CO2CH3; X is oxygen; Y is NR7; R7 is methyl; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE J1

[0675] Table J1 provides 352 compounds of formula (Ia) wherein R1 is methyl; R2 is hydrogen; R3 is CH2Ph; X and Y are each oxygen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE J2

[0676] Table J2 provides 352 compounds of formula (Ia) wherein R1 is methyl; R2 is fluoro; R3 is CH2Ph; X and Y are each oxygen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE J3

[0677] Table J3 provides 352 compounds of formula (Ia) wherein R1 is methyl; R2 is chloro; R3 is CH2Ph; X and Y are each oxygen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE J4

[0678] Table J4 provides 352 compounds of formula (Ia) wherein R1 is methyl, R2 is bromo; R3 is CH2Ph; X and Y are each oxygen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE J5

[0679] Table J5 provides 352 compounds of formula (Ia) wherein R1 is methyl; R2 is cyano; R3 is CH2Ph; X and Y are each oxygen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE J6

[0680] Table J6 provides 352 compounds of formula (Ia) wherein R is ethyl; R2 is hydrogen; R3 is CH2Ph; X and Y are each oxygen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE J7

[0681] Table J7 provides 352 compounds of formula (Ia) wherein R1 is ethyl; R2 is fluoro; RV is CH2Ph; X and Y are each oxygen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE J8

[0682] Table J8 provides 352 compounds of formula (Ia) wherein R1 is ethyl; R2 is chloro; R3 is CH2Ph; X and Y are each oxygen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE J9

[0683] Table J9 provides 352 compounds of formula (Ia) wherein R1 is ethyl; R2 is bromo; R3 is CH2Ph; X and Y are each oxygen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE J10

[0684] Table J10 provides 352 compounds of formula (Ia) wherein R1 is ethyl; R2 is cyano; R3 is CH2Ph; X and Y are each oxygen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE J11

[0685] Table J11 provides 352 compounds of formula (Ia) wherein R1 is methyl; R2 is hydrogen; R3 is CH2Ph; X is oxygen; Y is sulphur, n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE J12

[0686] Table J12 provides 352 compounds of formula (Ia) wherein R1 is methyl; R2 is fluoro; R3 is CH2Ph; X is oxygen; Y is sulphur, n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE J13

[0687] Table J13 provides 352 compounds of formula (Ia) wherein R1 is methyl; R2 is chloro; R3 is CH2Ph; X is oxygen; Y is sulphur, n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE J14

[0688] Table J14 provides 352 compounds of formula (Ia) wherein R1 is methyl; R2 is bromo; R3 is CH2Ph; X is oxygen; Y is sulphur, n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE J15

[0689] Table J15 provides 352 compounds of formula (Ia) wherein R1 is methyl; R2 is cyano; R3 is CH2Ph; X is oxygen; Y is sulphur; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE J16

[0690] Table J16 provides 352 compounds of formula (Ia) wherein R1 is ethyl; R1 is hydrogen; R3 is CH2Ph; X is oxygen; Y is sulphur; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE J17

[0691] Table J17 provides 352 compounds of formula (Ia) wherein R1 is ethyl; R2 is fluoro; R3 is CH2Ph; X is oxygen; Y is sulphur, n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE J18

[0692] Table 318 provides 352 compounds of formula (Ia) wherein R1 is ethyl; R2 is chloro; R3 is CH2Ph; X is oxygen; Y is sulphur; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE J19

[0693] Table J19 provides 352 compounds of formula (Ia) wherein R1 is ethyl; R2 is bromo; R3 is CH2Ph; X is oxygen; Y is sulphur, n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE J20

[0694] Table J20 provides 352 compounds of formula (Ia) wherein R1 is ethyl; R2 is cyano; R3 is CH2Ph; X is oxygen; Y is sulphur; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE 21

[0695] Table J21 provides 352 compounds of formula (Ib) wherein R1 is methyl; R2 is hydrogen; R3 is CH2Ph; X and Y are each oxygen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE J22

[0696] Table J22 provides 352 compounds of formula (Ib) wherein R1 is methyl; R2 is fluoro; R3 is CH2Ph; X and Y are each oxygen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE J23

[0697] Table J23 provides 352 compounds of formula (Ib) wherein R1 is methyl; R2 is chloro; R3 is CH2Ph; X and Y are each oxygen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE J24

[0698] Table J24 provides 352 compounds of formula (Ib) wherein R1 is methyl; R2 is bromo; R3 is CH2Ph; X and Y are each oxygen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE J25

[0699] Table J25 provides 352 compounds of formula (Tb) wherein R1 is methyl; R2 is cyano; R3 is CH2Ph; X and Y are each oxygen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE J26

[0700] Table J26 provides 352 compounds of formula (Ib) wherein R1 is ethyl; R2 is hydrogen; R3 is CH2Ph; X and Y are each oxygen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE J27

[0701] Table J27 provides 352 compounds of formula (Ib) wherein R1 is ethyl; R2 is fluoro; R3 is CH2Ph; X and Y are each oxygen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE J28

[0702] Table J28 provides 352 compounds of formula (Ib) wherein R1 is ethyl; R2 is chloro; R3 is CH2Ph; X and Y are each oxygen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE J29

[0703] Table J29 provides 352 compounds of formula (Ib) wherein R1 is ethyl; R2 is bromo; R3 is CH2Ph; X and Y are each oxygen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE J30

[0704] Table J30 provides 352 compounds of formula (Ib) wherein R1 is ethyl; R2 is cyano; R3 is CH2Ph; X and Y are each oxygen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE J31

[0705] Table J31 provides 352 compounds of formula (Ib) wherein R1 is methyl; R2 is hydrogen; R3 is CH2Ph; X is oxygen; Y is sulphur; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE J32

[0706] Table J32 provides 352 compounds of formula (Ib) wherein R1 is methyl; R2 is fluoro; R3 is CH2Ph; X is oxygen; Y is sulphur; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE J33

[0707] Table J33 provides 352 compounds of formula (Ib) wherein R1 is methyl; R2 is chloro; R3 is CH2Ph; X is oxygen; Y is sulphur; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE J34

[0708] Table J34 provides 352 compounds of formula (Ib) wherein R1 is methyl; R2 is bromo; R3 is CH2Ph; X is oxygen; Y is sulphur; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE J35

[0709] Table J35 provides 352 compounds of formula (ab) wherein R1 is methyl; R2 is cyan; R3 is CH2Ph; X is oxygen; Y is sulphur, n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

[0710] TABLE J36

[0711] Table J36 provides 352 compounds of formula (Ib) wherein R1 is ethyl; R2 is hydrogen; R3 is CH2Ph; X is oxygen; Y is sulphur, n is 0;and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE J37

[0712] Table 337 provides 352 compounds of formula (Ib) wherein R1 is ethyl; R2 is fluoro; R3 is CH2Ph; X is oxygen; Y is sulphur, n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE J38

[0713] Table J38 provides 352 compounds of formula (Ib) wherein R1 is ethyl; R2 is chloro; R3 is CH2Ph; X is oxygen; Y is sulphur, n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE J39

[0714] Table J39 provides 352 compounds of formula (Ib) wherein R1 is ethyl; R2 is bromo; R3 is CH2Ph; X is oxygen; Y is sulphur; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE J40

[0715] Table J40 provides 352 compounds of formula (Ib) wherein R1 is ethyl; R2 is cyano; R3 is CH2Ph; X is oxygen; Y is sulphur; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE J41

[0716] Table J41 provides 352 compounds of formula (ab) wherein R1 is methyl; R2 is a hydrogen; R3 is CH2Ph; X is oxygen; Y is NR7; R7 is hydrogen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE J42

[0717] Table J42 provides 352 compounds of formula (Ib) wherein R1 is methyl; R2 is is fluoro; R3 is CH2Ph; X is oxygen; Y is NR7; R7 is hydrogen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE J43

[0718] Table J43 provides 352 compounds of formula (Ib) wherein R1 is methyl; R2 is chloro; R3 is CH2Ph; X is oxygen; Y is NR7; R7 is hydrogen;-n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE J44

[0719] Table J44 provides 352 compounds of formula (Ib) wherein R1 is methyl, R2 is bromo; R3 is CH2Ph; X is oxygen; Y is NR7; R7 is hydrogen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE J45

[0720] Table J45 provides 352 compounds of formula (Ib) wherein R1 is methyl; R2 is cyano; R3 is CH2Ph; X is oxygen; Y is NR7; R7 is hydrogen; n is 0; and the values of RV match those of the correspondingly numbered compounds of Table A1.

TABLE J46

[0721] Table J46 provides 352 compounds of formula (Ib) wherein R1 is ethyl; R2 is hydrogen; R3 is CH2Ph; X is oxygen; Y is NR7; R7 is hydrogen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE J47

[0722] Table J47 provides 352 compounds of formula (Ib) wherein R1 is ethyl; R2 is fluoro; R3 is CH2Ph; X is oxygen; Y is NR7; R7 is hydrogen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE J48

[0723] Table J48 provides 352 compounds of formula (Ib) wherein R1 is ethyl; R2 is chloro; R3 is CH2Ph; X is oxygen; Y is NR7; R7 is hydrogen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE J49

[0724] Table J49 provides 352 compounds of formula (Ib) wherein R1 is ethyl; R2 is bromo; R3 is CH2Ph; X is oxygen; Y is NR7; R7 is hydrogen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE J50

[0725] Table J50 provides 352 compounds of formula (Ib) wherein R1 is ethyl; R2 is cyano; R3 is CH2Ph; X is oxygen; Y is NR7; R7 is hydrogen; n is 0; and the values of 4 match those of the correspondingly numbered compounds of Table A1.

TABLE J51

[0726] Table J51 provides 352 compounds of formula (Ib) wherein R1 is methyl; R2 is hydrogen; R3 is CH2Ph; X is oxygen; Y is NR7; R1 is methyl; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE J52

[0727] Table J52 provides 352 compounds of formula (Ib) wherein R1 is methyl; R2 is fluoro; R3 is CH2Ph; X is oxygen; Y is NR7; R1 is methyl; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE J53

[0728] Table J53 provides 352 compounds of formula (Ib) wherein R1 is methyl; R2 is chloro; R3 is CH2Ph; X is oxygen; Y is NR7; R7 is methyl; n is 0; and the values of R4 match those of the corresondingly numbered compounds of Table A1.

TABLE J54

[0729] Table J54 provides 352 compounds of formula (Ib) wherein R1 is methyl; R2 is bromo; R3 is CH2Ph; X is oxygen; Y is NR7; R7 is methyl; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE J55

[0730] Table J55 provides 352 compounds of formula (Ib) wherein R1 is methyl; R2 is cyano; R3 is CH2Ph; X is oxygen; Y is NR7; R7 is methyl; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE J56

[0731] Table J56 provides 352 compounds of formula (Ib) wherein R1 is ethyl; R2 is hydrogen; R3 is CH2Ph; X is oxygen; Y is NR7; R7 is methyl; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE 357

[0732] Table J57 provides 352 compounds of formula (Ib) wherein R1 is ethyl; R2 is fluoro; R3 is CH2Ph; X is oxygen; Y is NR7; R7 is methyl; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE J58

[0733] Table J58 provides 352 compounds of formula (Ib) wherein R1 is ethyl; R2 is chloro; R3 is CH2Ph; X is oxygen; Y is NR7; R7 is methyl; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE J59

[0734] Table J59 provides 352 compounds of formula (Ib) wherein is ethyl; R2 is bromo; R3 is CH2Ph; X is oxygen; Y is NR7; R7 is methyl; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE J60

[0735] Table J60 provides 352 compounds of formula (Ib) wherein R1 is ethyl; R2 is cyano; R3 is CH2Ph; X is oxygen; Y is NR7; R3 is methyl; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE J61

[0736] Table J61 provides 352 compounds of formula (Ia) wherein R1 is methyl; R2 is hydrogen; R3 is CH2Ph; X is oxygen; Y is NR7; R7 is methyl; n is 0; and the values of R4 match tose of the correspondingly numbered compounds of Table A1.

TABLE J62

[0737] Table J62 provides 352 compounds of formula (Ia) wherein R1 is methyl; R2 is fluoro; R3 is CH2Ph; X is oxygen; Y is NR7; R1 is methyl; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE J63

[0738] Table J63 provides 352 compounds of formula (Ia) wherein R1 is methyl; R2 is chloro; R3 is CH2Ph; X is oxygen; Y is NR7; R7 is methyl; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE J64

[0739] Table J64 provides 352 compounds of formula (Ia) wherein R1 is methyl; R2 is bromo; R3 is CH2Ph; X is oxygen; Y is NR7; R7 is methyl; n is 0; and the values of 4 match those of the correspondingly numbered compounds of Table A1.

TABLE J65

[0740] Table J65 provides 352 compounds of formula (Ib) wherein R1 is methyl; R2 is cyano; R3 is CH2Ph; X is oxygen; Y is NR7; R7 is methyl; n is 0; and the values of R4 match those of othe correspondingly numbered compounds of Table A1.

TABLE J66

[0741] Table J66 provides 352 compounds of formula (Ia) wherein Rl is ethyl; R2 is hydrogen; R3 is CH2Ph; X is oxygen; Y is NR7; R7is methyl; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE J67

[0742] Table J67 provides 352 compounds of formula (Ia) wherein R1 is ethyl; l2 is fluoro; R3 is CH2Ph; X is oxygen; Y is NR7; R7 is methyl; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE J68

[0743] Table J68 provides 352 compounds of formula (Ia) wherein R1 is ethyl; R2 is chloro; R3 is CH2Ph; X is oxygen; Y is NR7; R7 is methyl; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE J69

[0744] Table J69 provides 352 compounds of formula (Ia) wherein R1 is ethyl; R2 is bromo; R3 is CH2Ph; X is oxygen; Y is NR7; R7 is methyl; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE J70

[0745] Table J70 provides 352 compounds of formula (Ia) wherein R1 is ethyl; R2 is cyano; R3 is CH2Ph; X is oxygen; Y is NRC; R7 is methyl; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE K1

[0746] Table K1 provides 352 compounds of formula (Ia) wherein R1 is methyl; R2 is hydrogen; R3 is CH2OCH3; X and Y are each oxygen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE K2

[0747] Table K2 provides 352 compounds of formula (Ia) wherein R1 is methyl; R2 is fluoro; is R3 is CH2OCH3; X and Y are each oxygen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE K3

[0748] Table K3 provides 352 compounds of formula (Ia) wherein R1 is methyl; R2 is chloro; R3 is CH2OCH3; X and Y are each oxygen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE K4

[0749] Table K4 provides 352 compounds of formula (Ia) wherein R1 is methyl; R2 is bromo; R3 is CH2OCH3; X and Y are each oxygen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE K5

[0750] Table K5 provides 352 compounds of formula (Ia) wherein R1 is methyl; R2 is cyano; R3 is CH2OCH3; X and Y are each oxygen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE K6

[0751] Table K6 provides 352 compounds of formula (Ia) wherein R1 is ethyl; R2 is hydrogen; R3 is CH2OCH3; X and Y are each oxygen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE K7

[0752] Table K7 provides 352 compounds of formula (Ia) wherein R1 is ethyl; R2 is fluoro; R3 is CH2OCH3; X and Y are each oxygen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE K8

[0753] Table K8 provides 352 compounds of formula (Ia) wherein R1 is ethyl; R2 is chloro; R3 is CH2OCH3; X and Y are each oxygen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE K9

[0754] Table K9 provides 352 compounds of formula (Ia) wherein RV is ethyl; R2 is bromo; R3 is CH2OCH3; X and Y are each oxygen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE K10

[0755] Table K10 provides 352 compounds of formula (Ia) wherein R1 is ethyl; R2 is cyano; R3 is CH2OCH3; X and Y are each oxygen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE K11

[0756] Table K11 provides 352 compounds of formula (Ia) wherein R1 is methyl; R2 is hydrogen; R3 is CH20CH3; X is oxygen; Y is sulphur, n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE K12

[0757] Table K12 provides 352 compounds of formula (Ia) wherein R1 is methyl; R2 is fluoro; R3 is CH2OCH3; X is oxygen; Y is sulphur, n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE K13

[0758] Table K13 provides 352 compounds of formula (Ia) wherein R1 is methyl; R2 is chloro; R3 is CH2OCH3; X is oxygen; Y is sulphur, n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE K14

[0759] Table K14 provides 352 compounds of formula (Ia) wherein R1 is methyl; R2 is bromo; R3 is CH2OCH3; X is oxygen; Y is sulphur; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE K15

[0760] Table K15 provides 352 compounds of formula (Ia) wherein R1 is methyl; R2 is cyano; R3 is CH2OCH3; X is oxygen; Y is sulphur; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE K16

[0761] Table K16 provides 352 compounds of formula (Ia) wherein R1 is ethyl; R2 is hydrogen; R3 is CH2OCH3; X is oxygen; Y is sulphur; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE K17

[0762] Table K17 provides 352 compounds of formula (Ia) wherein R1 is ethyl; R2 is fluoro; R3 is CH20CH3; X is oxygen; Y is sulphur; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE K18

[0763] Table K18 provides 352 compounds of formula (Ia) wherein R1 is ethyl; R2 is chloro; R3 is CH2OCH3; X is oxygen; Y is sulphur, n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE K19

[0764] Table K19 provides 352 compounds of formula (Ia) wherein R1 is ethyl; R2 is bromo; R3 is CH2OCH3; X is oxygen; Y is sulphur, n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE K20

[0765] Table K20 provides 352 compounds of formula (Ia) wherein R1 is ethyl; R2 is cyano; R3 is CH2OCH3; X is oxygen; Y is sulphur, n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE K21

[0766] Table K21 provides 352 compounds of formula (Ib) wherein R1 is methyl; R2 is hydrogen; R3 is CH2OCH3; X and Y are each oxygen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE K22

[0767] Table K22 provides 352 compounds of formula (Ib) wherein R1 is methyl; R2 is fluoro; R3 is CH2OCH3; X and Y are each oxygen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE K23

[0768] Table K23 provides 352 compounds of formula (Ib) wherein R1 is methyl; R2 is chloro; R3 is CH2OCH3; X and Y are each oxygen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE K24

[0769] Table K24 provides 352 compounds of formula (Ib) wherein R1 is methyl; R2 is bromo; R3 is CH2OCH3; X and Y are each oxygen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE K25

[0770] Table K25 provides 352 compounds of formula (Ib) wherein R1 is methyl; R2 is cyano; R3 is CH2OCH3; X and Y are each oxygen, n is 0,; and the values ofV match those of the correspondingly numbered compounds of Table A1.

TABLE K26

[0771] Table K26 provides 352 compounds of formula (Ib) wherein R1 is ethyl; R2 is hydrogen; R3 is CH2OCH, X and Y are each oxygen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE K27

[0772] Table K27 provides 352 compounds of formula (Ib) wherein R1 is ethyl; R2 is fluoro; R3 is CHO2CH3; X and Y are each oxygen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE K28

[0773] Table K28 provides 352 compounds of formula (Ib) wherein R1 is ethyl; R2 is chloro; R3 is CH2OCH3; X and Y are each oxygen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE K29

[0774] Table K29 provides 352 compounds of formula (Ib) wherein R1 is ethyl; R2 is bromo; R3 is CH2OCH3; X and Y are each oxygen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE K30

[0775] Table K30 provides 352 compounds of formula (Ib) wherein R1 is ethyl; R2 is cyano; R3 is CH2OCH3; X and Y are each oxygen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE K131

[0776] Table K3 1 provides 352 compounds of formula (Ib) wherein R1 is methyl; R2 is hydrogen; R3 is CH2OCH3; X is oxygen; Y is sulphur; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE K32

[0777] Table K32 provides 352 compounds of formula (Ib) wherein R1 is methyl; R2 is fluoro; R3 is CH2OCH3; X is oxygen; Y is sulphur, n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE K33

[0778] Table K33 provides 352 compounds of formula (Ib) wherein R1 is methyl, R2 is chloro; R3 is CH2OCH3; X is oxygen; Y is sulphur, n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE K34

[0779] Table K34 provides 352 compounds of formula (Ib) wherein R1 is methyl; R2 is bromo; R3 is CH20CH3; X is oxygen; Y is sulphur; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE: K35

[0780] Table K35 provides 352 compounds of formula (Ib) wherein R1 is methyl; R2 is cyano; R3 is CH2OCH3; X is oxygen; Y is sulphur, n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE K36

[0781] Table K36 provides 352 compounds of formula (Ib) wherein R1 is ethyl; R2 is hydrogen; R3 is CH2OCH3; X is oxygen; Y is sulphur; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE K37

[0782] Table K37 provides 352 compounds of formula (Ib) wherein R1 is ethyl; R2 is fluoro; R3 is CH2OCH3; X is oxygen; Y is sulphur; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE K38

[0783] Table K38 provides 352 compounds of formula (Ib) wherein R1 is ethyl; R2 is chloro; R3 is CH20CH3; X is oxygen; Y is sulphur; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE K39

[0784] Table K39 provides 352 compounds of formula (Ib) wherein R1 is ethyl; R2 is bromo; R3 is CH2OCH3; X is oxygen; Y is sulphur; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE K40

[0785] Table K40 provides 352 compounds of formula (Ib) wherein R1 is ethyl; R2 is cyano; R3 is CH20CH3; X is oxygen; Y is sulphur, n is 0; and the values of le match those of the correspondingly numbered compounds of Table A1.

TABLE K41

[0786] Table K41 provides 352 compounds of formula (Ib) wherein R1 is methyl; R2 is hydrogen; R3 is CH2OCH3; X is oxygen; Y is NR7; R7 is hydrogen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE K42

[0787] Table K42 provides 352 compounds of formula (Ib) wherein R1 is methyl; R2 is fluoro; R3 is CH2OCH3; X is oxygen; Y is NR7; R1 is hydrogen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE K43

[0788] Table K43 provides 352 compounds of formula (Ib) wherein R1 is methyl; R2 is chloro; R3 is CH2OCH3; X is oxygen; Y is NR7; R7 is hydrogen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE K44

[0789] Table K44 provides 352 compounds of formula (Ib) wherein R1 is methyl; R2 is bromo; R3 is CH2OCH3; X is oxygen; Y is NR7; R7 is hydrogen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE K45

[0790] Table K45 provides 352 compounds of formula (Ib) wherein R1 is methyl; R2 is cyano; R3 is CH2OCH3; X is oxygen; Y is NR7; R7 is hydrogen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE K46

[0791] Table K46 provides 352 compounds of formula (Ib) wherein R1 is ethyl; R2 is hydrogen; R3 is CH2OCH3; X is oxygen; Y is NR7; R7 is hydrogen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE K47

[0792] Table K47 provides 352 compounds of formula (Ib) wherein R1 is ethyl; R2 is fluoro; is R3 is CH2OCH3; X is oxygen; Y is NR7; R7 is hydrogen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE K48

[0793] Table K48 provides 352 compounds of formula (Ib) wherein R1 is ethyl; R2 is chloro; R3 is CH2OCH3; X is oxygen; Y is NR7; R4 is hydrogen; n is 0; and the values of R match those of the correspondingly numbered compounds of Table A1.

TABLE K49

[0794] Table K49 provides 352 compounds of formula (Ib) Wherein R1 is ethyl; R2 is bromo; R3 is CH2OCH3; X is oxygen; Y is NR7; R7 is hydrogen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE K50

[0795] Table K50 provides 352 compounds of formula (Ib) wherein R1 is ethyl; R2 is cyano; R3 is CH2OCH3; X is oxygen; Y is NR7; R7 is hydrogen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE K51

[0796] Table K51 provides 352 compounds of formula (Ib) wherein R1 is methyl; R2 is hydrogen; R3 is CH2OCH3; X is oxygen; Y is NR7; R7 is methyl; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE K52

[0797] Table K52 provides 352 compounds of formula (Ib) wherein R1 is methyl; R2 is fluoro; R3 is CH2OCH3; X is oxygen; Y is NR7; R7 is methyl; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE K53

[0798] Table K53 provides 352 compounds of formula (Ib) wherein R1 is methyl; R2 is chloro; R3 is CH2OCH3; X is oxygen; Y is NR7; R7 is methyl; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE K54

[0799] Table K54 provides 352 compounds of formula (Ib) wherein R1 is methyl; R2 is bromo; R3 is CH20CH3; X is oxygen; Y is NR7; R7 is methyl; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE K55

[0800] Table K55 provides 352 compounds of formula (Ib) wherein R1 is methyl; R2 is cyano; R3 is CH2OCH3; X is oxygen; Y is NR7; R7 is methyl; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

[0801] Table K56 provides 352,compounds of formula (Ib) wherein R1 is ethyl; R2 is hydrogen; R3 is CH2OCH3; X is oxygen; Y is NR7; R7 is methyl n is; and the values R4 match those of the correspondingly numbered compounds of Table A1.

TABLE K57

[0802] Table K57 provides 352 compounds of formula (Ib) wherein R1 is ethyl; R2 is fluoro; R3 is CH2OCH3; X is oxygen; Y is NR7; R7 is methyl; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE K58

[0803] Table K58 provides 352 compounds of formula (Ib) wherein R1 is ethyl; R2 is chloro; R3 is CH2OCH3; X is oxygen; Y is NR7; R7 is methyl; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE K59

[0804] Table K59 provides 352 compounds of formula (Ib) wherein R1 is ethyl; R2 is bromo; R3 is CH2OCH3; X is oxygen; Y is NR7; R7 is methyl; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE K60

[0805] Table K60 provides 352 compounds of formula (Ib) wherein R1 is ethyl; R2 is cyano; R3 is CH2OCH3; X is oxygen; Y is NR7; R7 is methyl; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE K61

[0806] Table K61 provides 352 compounds of formula (Ia) wherein R1 is methyl; R2 is hydrogen; R3 is CH2OCH3; X is oxygen; Y is NR7; R7 is methyl; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE K62

[0807] Table K62 provides 352 compounds of formula (Ia) wherein R1 is methyl; R2 is fluoro; R3 is CH2OCH3; X is oxygen; Y is NR7; R7 is methyl; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE K63

[0808] Table K63 provides 352 compounds of formula (Ia) wherein R1 is methyl; R2 is chloro; R3 is CH2OCH3; X is oxygen; Y is NR7; R7 is methyl; n is 0; and the values of R4 match those of the correspondingly number compounds of Table A1.

TABLE K64

[0809] Table K64 provides 352 compounds of formula (Ia) wherein R1 is methyl; R2 is bromo; R3 is CH2OCH3; X is oxygen; Y is NR7; R7 is methyl; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE K65

[0810] Table K65 provides 352 compounds of formula (Ib) wherein R1 is methyl; R2 is cyano; R3 is CH2OCH3; X is oxygen; Y is NR7; R7 is methyl, n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE K66

[0811] Table K66 provides 352 compounds of formula (Ia) wherein R1 is ethyl; R2 is hydrogen; R3 is CH2OCH3; X is oxygen; Y is NR7; R7 is methyl; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE K67

[0812] Table K67 provides 352 compounds of formula (Ia) wherein R1 is ethyl; R2 is fluoro; R3 is CH2OCH3; X is oxygen; Y is NR7; R7 is methyl; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE K68

[0813] Table K68 provides 352 compounds of formula (Ia) wherein R1 is ethyl; R2 is chloro; R3 is CH2OCH3; X is oxygen; Y is NR7; R7 is methyl; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE K69

[0814] Table K69 provides 352 compounds of formula (Ia) wherein R1 is ethyl; R2 is bromo; R3 is CH2OCH3; X is oxygen; Y is NR7; R7 is methyl; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE K70

[0815] Table K70 provides 352 compounds of formula (Ia) wherein R1 is ethyl; R2 is cyano; R3 is CH2OCH3; X is oxygen; Y is NR7; R7 is methyl; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE L1

[0816] Table L1 provides 352 compounds of formula (Ia) wherein R1 is methyl; R2 is hydrogen; R3 is CH2OCH2CH3; X and Y are each oxygen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE L2

[0817] Table L2 provides 352 compounds of formula (Ia) wherein R1 is methyl; R2 is fluoro, R3 is CH2OCH2CH3; X and Y are each oxygen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE L3

[0818] Table L3 provides 352 compounds of formula (Ia) wherein R1 is methyl; R2 is chloro; R3 is CH2OCH2CH3; X and Y are each oxygen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE L4

[0819] Table L4 provides 352 compounds of formula (Ia) wherein R1 is methyl; R2 is bromo; R3 is CH2OCH2CH3; X and Y are each oxygen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE L5

[0820] Table L5 provides 352 compounds of formula (Ia) wherein R1 is methyl; R2 is cyano; R3 is CH2OCH2CH3; X and Y are each oxygen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE L6

[0821] Table L6 provides 352 compounds of formula (Ia) wherein R1 is ethyl; R2 is hydrogen; R3 is CH2OCH2CH3; X and Y are each oxygen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE L7

[0822] Table L7 provides 352 compounds of formula (Ia) wherein R1 is ethyl; R2 is fluoro; R3 is CH2OCH2CH3; X and Y are each oxygen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE L8

[0823] Table L8 provides 352 compounds of formula (Ia) wherein R1 is ethyl; R2 is chloro; R3 is CH2OCH2CH3; X and Y are each oxygen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE L9

[0824] Table L9 provides 352 compounds of formula (Ia) wherein R1 is ethyl R2 is bromo; R3 is CH2OCH2CH3; X and Y are each oxygen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE L10

[0825] Table L10 provides 352 compounds of formula (Ia) wherein R1 is ethyl; R2 is cyano; R3 is CH2OCH2CH3; X and Y are each oxygen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE L11

[0826] Table L11 provides 352 compounds of formula (Ia) wherein R1 is methyl; R2 is hydrogen; R3 is CH2OCH2CH3; X is oxygen; Y is sulphur; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE L12

[0827] Table L12 provides 352 compounds of formula (Ia) wherein R1 is methyl; R2 is fluoro; R3 is CH2OCH2CH3; X is oxygen; Y is sulphur; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE L13

[0828] Table L13 provides 352 compounds of formula (Ia) wherein R1 is methyl; R2 is chloro; R3 is CH2OCH2CH3; X is oxygen; Y is sulphur; n is 0; and the values of R1 match those of the correspondingly numbered compounds of Table A1.

TABLE L14

[0829] Table L14 provides 352 compounds of formula (Ia) wherein R1 is methyl; R2 is bromo; R3 is CH2OCH2CH3; X is oxygen; Y is sulphur; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE L15

[0830] Table L15 provides 352 compounds of formula (Ia) wherein R1 is methyl; R2 is cyano; R3 is CH2OCH2CH3; X is oxygen; Y is sulphur, n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE L16.

[0831] Table L16 provides 352 compounds of formula (Ia) wherein R1 is ethyl; R2 is hydrogen; R3 is CH2OCH2CH3; X is oxygen; Y is sulphur, n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE L17

[0832] Table L17 provides 352 compounds of formula (Ia) wherein R1 is ethyl; R2 is fluoro; R3 is CH2OCH2CH3; X is oxygen; Y is sulphur, n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE L18

[0833] Table L18 provides 352 compounds of formula (Ia) wherein R1 is ethyl; R2 is chloro; R3 is CH2OCH2CH3; X is oxygen; Y is sulphur, n is 0; and the values of RV match those of the correspondingly numbered compounds of Table A1.

TABLE L19

[0834] Table L19 provides 352 compounds of formula (Ia) wherein R1 is ethyl; R2 is bromo; R3 is CH2OCH2CH3; X is oxygen; Y is sulphur; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE L20

[0835] Table L20 provides 352 compounds of formula (Ia) wherein R1 is ethyl; R2 is cyano; R3 is CH2OCH2CH3; X is oxygen; Y is sulphur; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE L21

[0836] Table L21 provides 352 compounds of formula (Ib) wherein R1 is methyl; R2 is hydrogen; R3 is CH2OCH2CH3; X and Y are each oxygen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE L22

[0837] Table L22 provides 352 compounds of formula (Ib) wherein R1 is methyl; R2 is fluoro; R3 is CH2OCH2CH3; X and Y are each oxygen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE L23

[0838] Table L23 provides 352 compounds of formula (Ib) wherein R1 is methyl; R2 is chloro; R3 is CH2OCH2CH3; X and Y are each oxygen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE L24

[0839] Table L24 provides 352 compounds of formula (Ib) wherein R1 is methyl; R2 is bromo; R3 is CH2OCH2CH3; X and Y are each oxygen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE L25

[0840] Table L25 provides 352 compounds of formula (Ib) wherein R1 is methyl; R2 is cyano; R3 is CH2OCH2CH3; X and Y are each oxygen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE L26

[0841] Table L26 provides 352 compounds of formula (Ib) wherein R1 is ethyl; R2 is hydrogen; R3 is CH2OCH2CH3; X and Y are each oxygen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE L27

[0842] Table L27 provides 352 compounds of formula (Ib) wherein R1 is ethyl; R2 is fluoro; R3 is CH2OCH2CH3; X and Y are each oxygen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE L28

[0843] Table L28 provides 352 compounds of formula (Ib) wherein R1 is ethyl; R2 is chloro; R3 is CH2OCH2CH3; X and Y are each oxygen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE L29

[0844] Table L29 provides 352 compounds of formula (Ib) wherein R1 is ethyl; R2 is bromo; R3 is CH2OCH2CH3; X and Y are each oxygen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE L30

[0845] Table L30 provides 352 compounds of formula (Ib) wherein R1 is ethyl; R2 is cyano; R3 is CH2OCH2CH3; X and Y are each oxygen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE L31

[0846] Table L31 provides 352 compounds of formula (Ib) wherein R1 is methyl; R2 is hydrogen; R3 is CH2OCH2CH3; X is oxygen; Y is sulphur, n is 0, and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE L32

[0847] Table L32 provides 352 compounds of formula (Ib) wherein R1 is methyl; R2 is fluoro; R3 is CH2OCH2CH3; X is oxygen; Y is sulphur; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE L33

[0848] Table L33 provides 352 compounds of formula (Ib) wherein R1 is methyl; R2 is chloro; R3 is CH2OCH2CH3; X is oxygen; Y is sulphur, n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE L34

[0849] Table L34 provides 352 compounds of formula (Ib) wherein R1 is methyl; R2 is bromo; R3 is CH2OCH2CH3; X is oxygen; Y is sulphur; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE L35

[0850] Table L35 provides 352 compounds of formula (Ib) wherein R1 is methyl; R2 is cyano; R3 is CH2OCH2CH3; X is oxygen; Y is sulphur, n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE L36

[0851] Table L36 provides 352 compounds of formula (Ib) wherein R1 is ethyl; R2 is hydrogen; R3 is CH2OCH2CH3; X is oxygen; Y is sulphur; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE L37

[0852] Table L37 provides 352 compounds of formula (Ib) wherein R1 is ethyl; R2 is fluoro; R3 is CH2OCH2CH3; X is oxygen; Y is sulphur; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE L38

[0853] Table L38 provides 352 compounds of formula (Ib) wherein R1 is ethyl; R2 is chloro; R3 is CH2OCH2CH3; X is oxygen; Y is sulphur, n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE L39

[0854] Table L39 provides 352 compounds of formula (Ib) wherein R1 is ethyl; R2 is bromo; R3 is CH2OCH2CH3; X is oxygen; Y is sulphur, n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE L40

[0855] Table L40 provides 352 compounds of formula (Ib) wherein R1 is ethyl; R2 is cyano; R3 is CH2OCH2CH3; X is oxygen; Y is sulphur, n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE L41

[0856] Table L41 provides 352 compounds of formula (Ib) wherein R1 is methyl; R2 is hydrogen; R3 is CH2OCH2CH3; X is oxygen; Y is NR7; R7 is hydrogen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE L42

[0857] Table L42 provides 352 compounds of formula (Ib) wherein R1 is methyl; R2 is fluoro; R3 is CH2OCH2CH3; X is oxygen; Y is NR7; R1 is hydrogen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE L43

[0858] Table L43 provides 352 compounds of formula (Ib) wherein R1 is methyl; R2 is chloro; R3 is CH2OCH2CH3; X is oxygen; Y is NR7; R7 is hydrogen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE L44

[0859] Table L44 provides 352 compounds of formula (Ib) wherein R1 is methyl; R2 is bromo; R3 is CH2OCH2CH3; X is oxygen; Y is NR7; R7 is hydrogen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE LA5

[0860] Table L45 provides 352 compounds of formula (Ib) wherein R1 is methyl; R2 is cyano; R3 is CH2OCH2CH3; X is oxygen; Y is NR7; R7 is hydrogen; n is 0; and the values of R4 match those of the correspondingly numbered-compounds of Table A1.

TABLE L46

[0861] Table L46 provides 352 compounds of formula (Ib) wherein R1 is ethyl; R2 is hydrogen; R3 is CH2OCH2,CH3; X is oxygen; Y is NR7; R7 is hydrogen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE L47

[0862] Table L47 provides 352 compounds of formula (Ib) wherein R1 is ethyl; R2 is fluoro; R3 is CH2OCH2CH3; X is oxygen; Y is NR7; R7 is hydrogen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE L48

[0863] Table L48 provides 352 compounds of formula (Ib) wherein R1 is ethyl; R2 is chloro; R3 is CH20CH2CH3; X is oxygen; Y is NR7; R7 is hydrogen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE L49

[0864] Table L49 provides 352 compounds of formula (Ib) wherein R1 is ethyl; R2 is bromo; R3 is CH2OCH2CH3; X is oxygen; Y is NR7; R7 is hydrogen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE L50

[0865] Table L50 provides 352 compounds of formula (b) wherein R1 is ethyl; R2 is cyano; R3 is CH2OCH2CH3; X is oxygen; Y is NR7; R7 is hydrogen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE L51

[0866] Table L51 provides 352 compounds of formula (Ib) wherein R1 is methyl; R2 is hydrogen; R3 is CH2OCH2CH3; X is oxygen; Y is NR7; R7 is methyl; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE L52

[0867] Table L52 provides 352 compounds of formula (b) wherein R1 is methyl; R2 is fluoro; R3 is CH2OCH2CH3; X is oxygen; Y is NR7; R7 is methyl; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE L53

[0868] Table L53 provides 352 compounds of formula (Ib) wherein R1 is methyl; R2 is chloro; R3 is CH2OCH2CH3; X is oxygen; Y is NR7; R7 is methyl; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE L54

[0869] Table L54 provides 352 compounds of formula (Ib) wherein R1 is methyl; R2 is bromo; R3 is CH2OCH2CH3; X is oxygen; Y is NR7; R7 is methyl; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE L55

[0870] Table L55 provides 352 compounds of formula (Ib) wherein R1 is methyl; R2 is cyano; R3 is CH2OCH2CH3; X is oxygen; Y is NR7; R7 is methyl; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE L56

[0871] Table L56 provides 352 compounds of formula (Ib) wherein R1 is ethyl; R1 is hydrogen; R3 is CH2OCH2CH3; X is oxygen; Y is NR7; R7 is methyl; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE L57

[0872] Table L57 provides 352 compounds of formula (Ib) wherein R1 is ethyl; R2 is fluoro; R3 is CH2OCH2CH3; X is oxygen; Y is NR7; R7 is methyl; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE L58

[0873] Table L58 provides 352 compounds of formula (Ib) wherein R1 is ethyl; R2 is chloro; R3 is CH2OCH2CH3; X is oxygen; Y is NR7; R7 is methyl; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE L59

[0874] Table L59 provides 352 compounds of formula (Ib) wherein R1 is ethyl; R2 is bromo; R3 is CH2OCH2CH3; X is oxygen; Y is NR7; R4 is methyl; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE L60

[0875] Table L60 provides 352 compounds of formula (Ib) wherein R1 is ethyl; R2 is cyano; R3 is CH2OCH2CH3; X is oxygen; Y is NR7; R7 is methyl; n is 0; and the values of R match those of the correspondingly numbered compounds of Table A1.

TABLE L61

[0876] Table L61 provides 352 compounds of formula (Ia) wherein R1 is methyl; R2 is hydrogen; R3 is CH2OCH2CH3; X is oxygen; Y is NR7; R7 is methyl; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE L62

[0877] Table L62 provides 352 compounds of formula (Ia) wherein R1 is methyl; R2 is fluoro; R3 is CH2OCH2CH3; X is oxygen; Y is NR7; R7 is methyl; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE L63

[0878] Table L63 provides 352 compounds of formula (Ia) wherein R1 is methyl; R2 is chloro; R3 is CH2OCH2CH3; X is oxygen; Y is NR7; R7 is methyl; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE L64

[0879] Table L64 provides 352 compounds of formula (Ia) wherein R1 is methyl; R2 is bromo; R3 is CH2OCH2CH3; X is oxygen; Y is NR7; R7 is methyl; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE L65

[0880] Table L65 provides 352 compounds of formula (Ib) wherein R1 is methyl; R2 is cyano; R3 is CH2OCH2CH3; X is oxygen; Y is NR7; R7 is methyl; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE L66

[0881] Table L66 provides 352 compounds of formula (Ia) wherein R1 is ethyl; R2 is hydrogen; R3 is CH2OCH2CH3; X is oxygen; Y is NR7; R7 is methyl; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE L67

[0882] Table L67 provides 352 compounds of formula (Ia) wherein R1 is ethyl; R2 is fluoro; R3 is CH2OCH2CH3; X is oxygen; Y is NR7; R7 is methyl; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE L68

[0883] Table L68 provides 352 compounds of formula (Ia) wherein R1 is ethyl; R2 is chloro; R3 is CH2OCH2CH3; X is oxygen; Y is NR7; R7 is methyl; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE L69

[0884] Table L69 provides 352 compounds of formula (Ia) wherein R1 is ethyl; R2 is bromo; R3 is CH2OCH2CH3; X is oxygen; Y is NR7; R7 is methyl; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE L70

[0885] Table L70 provides 352 compounds of formula (Ia) wherein R1 is ethyl; R2 is cyano; R3 is CH2OCH2CH3; X is oxygen; Y is NR7; R7 is methyl; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE M1

[0886] Table M1 provides 352 compounds of formula (Ia) wherein R1 is methyl; R2 is hydrogen; R3 is CH2OCH2CH2OCH3; X and Y are each oxygen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE M2

[0887] Table M2 provides 352 compounds of formula (Ia) wherein R1 is methyl; R2 is fluoro; R3 is CH2OCH2CH2OCH3; X and Y are each oxygen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE M3

[0888] Table M3 provides 352 compounds of formula (Ia) wherein R1 is methyl; R2 is chloro; R3 is CH2OCH2CH2OCH3; X and Y are each oxygen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE M4

[0889] Table M4 provides 352 compounds of formula (Ia) wherein R1 is methyl; R2 is bromo; R3 is CH2OCH2CH2OCH3; X and Y are each oxygen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE M5

[0890] Table M5 provides 352 compounds of formula (Ia) wherein R1 is methyl; R2 is cyano; R3 is CH2OCH2CH2OCH3; X and Y are each oxygen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE M6

[0891] Table M6 provides 352 compounds of formula (Ia) wherein R1 is ethyl; R2 is hydrogen; R3 is CH2OCH2CH2OCH3; X and Y are each oxygen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE M7

[0892] Table M7 provides 352 compounds of formula (Ia) wherein R1 is ethyl; R2 is fluoro; R3 is CH2OCH2CH2OCH3; X and Y are each oxygen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE M8

[0893] Table M8 provides 352 compounds of formula (Ia) wherein R is ethyl; R2 is chloro; R3 is CH2OCH2CH2OCH3; X and Y are each oxygen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE M9

[0894] Table M9 provides 352 compounds of formula (Ia) wherein R1 is ethyl; R2 is bromo; R3 is CH2OCH2CH2OCH3; X and Y are each oxygen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE M10

[0895] Table M10 provides 352 compounds of formula (Ia) wherein R1 is ethyl; R2 is cyano; R3 is CH2OCH2CH2OCH3; X and Y are each oxygen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE M11

[0896] Table M11 provides 352 compounds of formula (Ia) wherein R1 is methyl; R2 is hydrogen; R3 is CH2OCH2CH2OCH3; X is oxygen; Y is sulphur, n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE M12

[0897] Table M12 provides 352 compounds of formula (Ia) wherein R1 is methyl; R2 is fluoro; R3 is CH2OCH2CH2OCH3; X is oxygen; Y is sulphur, n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE M13

[0898] Table M13 provides 352 compounds of formula (Ia) wherein R1 is methyl; R2 is chloro; R3 is CH2OCH2CH2OCH3; X is oxygen; Y is sulphur, n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE M14

[0899] Table M14 provides 352 compounds of formula (Ia) wherein R1 is methyl; R2 is bromo; R3 is CH2OCH2CH2OCH3; X is oxygen; Y is sulphur, n is 0; and the values of RX match those of the correspondingly numbered compounds of Table A1.

TABLE M15

[0900] Table M15 provides 352 compounds of formula (Ia) wherein R1 is methyl; R2 is cyano; R3 is CH2OCH2CH2OCH3; X is oxygen; Y is sulphur, n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE M16

[0901] Table M16 provides 352 compounds of formula (Ia) wherein R1 is ethyl; R2 is hydrogen; R3 is CH2OCH2CH2OCH3; X is oxygen; Y is sulphur; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE M17

[0902] Table M17 provides 352 compounds of formula (Ia) wherein R1 is ethyl; R2 is fluoro; R3 is CH2OCH2CH2OCH3; X is oxygen; Y is sulphur; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE M18

[0903] Table M18 provides 352 compounds of formula (Ia) wherein R1 is ethyl; R2 is chloro; R3 is CH2OCH2CH20CH3; X is oxygen; Y is sulphur; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE M19

[0904] Table M19 provides 352 compounds of formula (Ia) wherein R1 is ethyl; R2 is bromo; R3 is CH2OCH2CH2OCH3; X is oxygen; Y is sulphur; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE M20

[0905] Table M20 provides 352 compounds of formula (Ia) wherein R1 is ethyl; R2 is cyano; R3 is CH2OCH2CH2OCH3; X is oxygen; Y is sulphur; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE M21

[0906] Table M21 provides 352 compounds of formula (Ib) wherein R1 is methyl; R2is hydrogen; R3 is CH2.OCH2CH2OCH3; X and Y are each oxygen, n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE M22

[0907] Table M22 provides 352 compounds of formula (Ib) wherein R1 is methyl; R2 is fluoro; R3 is CH2OCH2CH2OCH3; X and Y are each oxygen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE M23

[0908] Table M23 provides 352 compounds of formula (Ib) wherein R1 is methyl; R2 is chloro; R3 is CH2OCH2CH2OCH3; X and Y are each oxygen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE M24

[0909] Table M24 provides 352 compounds of formula (Ib) wherein R1 is methyl; R2 is bromo; R3 is CH2OCH2CH2OCH3; X and Y are each oxygen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE M25

[0910] Table M25 provides 352 compounds of formula (Ib) wherein R1 is methyl; R2 is cyano; R3 is CH2OCH2CH2OCH3; X and Y are each oxygen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE M26

[0911] Table M26 provides 352 compounds of formula (Ib) wherein R1 is ethyl; R2 is hydrogen; R3 is CH2OCH2CH2OCH3; X and Y are each oxygen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE M27

[0912] Table M27 provides 352 compounds of formula (Ib) wherein R1 is ethyl; R2 is fluoro; R3 is CH2OCH2CH2OCH3; X and Y are each oxygen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE M28

[0913] Table M28 provides 352 compounds of formula (Ib) wherein R1 is ethyl; R2 is chloro; a R3 is CH2OCH2CH20CH3; X and Y are each oxygen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE M29

[0914] Table M29 provides 352 compounds of formula (Ib) wherein R1 is ethyl; R2 is bromo; R3 is CH2OCH2CH2OCH3; X and Y are each oxygen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE M30

[0915] Table M30 provides 352 compounds of formula (Ib) wherein R1 is ethyl; R2 is cyano; R3 is CH2OCH2CH2OCH3; X and Y are each oxygen; n is 0; and the values of RV match those of the correspondingly numbered compounds of Table A1.

TABLE M31

[0916] Table M31 provides 352 compounds of formula (Ib) wherein R1 is methyl; R2 is hydrogen; R3 is CH2OCH2CH2OCH3; X is oxygen; Y is sulphur; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE M32

[0917] Table M32 provides 352 compounds of formula (Ib) wherein R1 is methyl; R2 is fluoro; R3 is CH2OCH2CH2OCH3; X is oxygen; Y is sulphur, n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE M33

[0918] Table M33 provides 352 compounds of formula (Ib) wherein R1 is methyl; R2 is chloro; R3 is CH2OCH2CH2OCH3; X is oxygen; Y is sulphur; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE M34

[0919] Table M34 provides 352 compounds of formula (Ib) wherein R1 is methyl; R2 is bromo; R3 is CH2OCH2CH2OCH3; X is oxygen; Y is sulphur, n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE M35

[0920] Table M35 provides 352 compounds of formula (Ib) wherein R1 is methyl; R2 is cyano; R3 is CH2OCH2CH2OCH3; X is oxygen; Y is sulphur; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE M36

[0921] Table M36 provides 352 compounds of formula (Ib) wherein R1 is ethyl; R2 is hydrogen; R3 is CH2OCH2CH2OCH3; X is oxygen; Y is sulphur, n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE M37

[0922] Table M37 provides 352 compounds of formula (Ib) wherein R1 is ethyl; R2 is fluoro; R3 is CH2OCH2CH2OCH3; X is oxygen; Y is sulphur, n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE M38

[0923] Table M38 provides 352 compounds of formula (Ib) wherein R1 is ethyl; R2 is chloro; R3 is CH2OCH2CH20CH3; X is oxygen; Y is sulphur, n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE M39

[0924] Table M39 provides 352 compounds of formula (Ib) wherein R1 is ethyl; R2 is bromo; R3 is CH2OCH2CH2OCH3; X is oxygen; Y is sulphur; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE M40

[0925] Table M40 provides 352 compounds of formula (Ib) wherein R1 is ethyl; R2 is cyano; R3 is CH2OCH2CH2OCH3; X is oxygen; Y is sulphur; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE M41

[0926] Table M41 provides 352 compounds of formula (Ib) wherein R1 is methyl; R2 is hydrogen; R3 is CH2OCH2CH2OCH3; X is oxygen; Y is NR7; R1 is hydrogen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE M42

[0927] Table M42 provides 352 compounds of formula (Ib) wherein R1 is methyl; R2 is fluoro; R3 is CH2OCH2CH2OCH3; X is oxygen; Y is NR7; R1 is hydrogen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE M43

[0928] Table M43 provides 352 compounds of formula (Ib) wherein R1 is methyl; R2 is chloro; R3 is CH2OCH2CH2OCH3; X is oxygen; Y is NR7; R3 is hydrogen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE M44

[0929] Table M44 provides 352 compounds of formula (Ib) wherein R1 is methyl; R2 is bromo; R3 is CH2OCH2CH2OCH3; X is oxygen; Y is NR7; R7 is hydrogen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE M45

[0930] Table M45 provides 352 compounds of formula (Ib) wherein R1 is methyl; R2 is cyano; R3 is CH2OCH2CH2OCH3; X is oxygen; Y is NR7; R7 is hydrogen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE M46

[0931] Table M46 provides 352 compounds of formula (Ib) wherein R1 is ethyl; R2 is hydrogen; R3 is CH2OCH2CH2OCH3; X is oxygen; Y is NR7; R7 is hydrogen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE M47

[0932] Table M47 provides 352 compounds of formula (Ib) wherein R1 is ethyl; R2 is fluoro; R3 is CH2OCH2CH2OCH3; X is oxygen; Y is NR7; R7 is hydrogen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE M48

[0933] Table M48 provides 352 compounds of formula (Ib) wherein R1 is ethyl; R2 is chloro; R3 is CH2OCH2CH2OCH3; X is oxygen; Y is NR7; R7 is hydrogen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE M49

[0934] Table M49 provides 352 compounds of formula (Ib) wherein R1 is ethyl; R2 is bromo; R3 is CH2OCH2CH2OCH3; X is oxygen; Y is NR7; R7 is hydrogen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE M50

[0935] Table M50 provides 352 compounds of formula (Ib) wherein R1 is ethyl; R2 is cyano; R3 is CH2OCH2CH2OCH3; X is oxygen; Y is NR7; R7 is hydrogen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE M51

[0936] Table M51 provides 352 compounds of formula (Ib) wherein R1 is methyl; R2 is hydrogen; R3 is CH2OCH2CH2OCH3; X is oxygen; Y is NR7; R7 is methyl; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE M52

[0937] Table M52 provides 352 compounds of formula (Ib) wherein R1 is methyl; R2 is fluoro; R3 is CH2OCH2CH2OCH3; X is oxygen; Y is NR7; R7 is methyl; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE M53

[0938] Table M53 provides 352 compounds of formula (Ib) wherein R1 is methyl; R2 is chloro; R3 is CH2OCH2CH2OCH3; X is oxygen; Y is NR7; R7 is methyl; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE M54

[0939] Table M54 provides 352 compounds of formula (Ib) wherein R1 is methyl; R2 is bromo; R3 is CH2OCH2CH2OCH3; X is oxygen; Y is NR7; R7 is methyl; n is 0; and the-values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE M55

[0940] Table M55 provides 352 compounds of formula (Ib) wherein R1 is methyl; R2 is cyano; R3 is CH2OCH2CH2OCH3; X is oxygen; Y is NR7; R7 is methyl; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE M56

[0941] Table M56 provides 352 compounds of formula (Ib) wherein R1 is ethyl; R2 is hydrogen; R3 is CH2OCH2CH2OCH3; X is oxygen; Y is NR7; R7 is methyl; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE M57

[0942] Table M57 provides 352 compounds of formula (Ib) wherein R1 is ethyl; R2 is fluoro; R3 is CH2OCH2CH2OCH3; X is oxygen; Y is NR7; R7 is methyl; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE M58

[0943] Table M58 provides 352 compounds of formula (Ib) wherein R1 is ethyl; R2 is chloro; R3 is CH2OCH2CH2OCH3; X is oxygen; Y is NR7; R7 is methyl; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE M59

[0944] Table M59 provides 352 compounds of formula (Ib) wherein R1 is ethyl; R2 is bromo; R3 is CH2OCH2CH2OCH3; X is oxygen; Y is NR7; R7 is methyl; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE M60

[0945] Table M60 provides 352 compounds of formula (Ib) wherein R1 is ethyl; R2 is cyano; R3 is CH2OCH2CH2OCH3; X is oxygen; Y is NR7; R7 is methyl; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE M61

[0946] Table M61 provides 352 compounds of formula (Ia) wherein R1 is methyl; R2 is hydrogen; R3 is CH2OCH2CH2OCH3; X is oxygen; Y is NR7; R1 is methyl; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE M62

[0947] Table M62 provides 352 compounds of formula (Ia) wherein R1 is methyl; R2 is fluoro; R3 is CH2OCH2CH2OCH3; X is oxygen; Y is NR7; R7 is methyl; n is 0; and the values of R match those of the correspondingly numbered compounds of Table A1.

TABLE M63

[0948] Table M63 provides 352 compounds of formula (Ia) wherein R1 is methyl; R2 is chloro; R3 is CH2OCH2CH2OCH3; X is oxygen; Y is NR7; R7 is methyl; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE M64

[0949] Table M64 provides 352 compounds of formula (Ia) wherein R1 is methyl; R2 is bromo; R3 is CH2OCH2CH2OCH3; X is oxygen; Y is NR7; R7 is methyl; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE M65

[0950] Table M65 provides 352 compounds of formula (Ib) wherein R1 is methyl; R2 is cyano; R3 is CH2OCH2CH2OCH3; X is oxygen; Y is NR7; R7 is methyl; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE M66

[0951] Table M66 provides 352 compounds of formula (Ia) wherein R1 is ethyl; R2 is hydrogen; R3 is CH2OCH2CH2OCH3; X is oxygen; Y is NR7; R7 is methyl; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE M67

[0952] Table M67 provides 352 compounds of formula (Ia) wherein R1 is ethyl; R2 is fluoro; R3 is CH2OCH2CH2OCH3; X is oxygen; Y is NR7; R7 is methyl; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE M68

[0953] Table M68 provides 352 compounds of formula (Ia) wherein R1 is ethyl; R2 is chloro; R3 is CH2OCH2CH2OCH3; X is oxygen; Y is NR7; R7 is methyl; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE M69

[0954] Table M69 provides 352 compounds of formula (Ia) wherein R1 is ethyl; R2 is bromo; R3 is CH2OCH2CH2OCH3; X is oxygen; Y is NR7; R7 is methyl; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE M70

[0955] Table M70 provides 352 compounds of formula (Ia) wherein R1 is ethyl; R2 is cyano; R3 is CH2OCH2CH2OCH3; X is oxygen; Y is NR7; R7 is methyl; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE N1

[0956] Table N1 provides 352 compounds of formula (Ia) wherein R1 is methyl; R2 is hydrogen; R3 is CH(CH3)2; X and Y are each oxygen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE N2

[0957] Table N2-provides 352 compounds of formula (Ia) wherein R1 is methyl; R2 is fluoro; R3 is CH(CH3)2; X and Y are each oxygen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE N3

[0958] Table N3 provides 352 compounds of formula (Ia) wherein R1 is methyl; R2 is chloro; R3 is CH(CH3)2; X and Y are each oxygen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE N4

[0959] Table N4 provides 352 compounds of formula (Ia) wherein R1 is methyl; R2 is bromo; R3 is CH(CH3)2; X and Y are each oxygen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE N5

[0960] Table N5 provides 352 compounds of formula (Ia) wherein R1 is methyl; R2 is cyano; R3 is CH(CH3)2; X and Y are each oxygen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE N6

[0961] Table N6 provides 352 compounds of formula (Ia) wherein R1 is ethyl; R2 is hydrogen; R3 is CH(CH3)2; X and Y are each oxygen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE N7

[0962] Table N7 provides 352 compounds of formula (Ia) wherein R1 is ethyl; R2 is fluoro; R3 is CH(CH3)2; X and Y are each oxygen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE N8

[0963] Table N8 provides 352 compounds of formula (Ia) wherein R1 is ethyl; R2 is chloro; is CH(CH3)2; X and Y are each oxygen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE N9

[0964] Table N9 provides 352 compounds of formula (Ia) wherein R1 is ethyl; R2 is bromo; R3 is CH(CH3)2; X and Y are each oxygen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE N10

[0965] Table N10 provides 352 compounds of formula (Ia) wherein R1 is ethyl; R2 is cyano; R3 is CH(CH3)2; X and Y are each oxygen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE N11

[0966] Table N11 provides 352 compounds of formula (Ia) wherein R1 is methyl; R2is hydrogen; R3 is CH(CH3)2; X is oxygen; Y is sulphur, n is 0; and values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE N12

[0967] Table N12 provides 352 compounds of formula (Ia) wherein R1 is methyl; R2 is fluoro; R3 is CH(CH3)2; X is oxygen; Y is sulphur, n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE N13

[0968] Table N13 provides 352 compounds of formula (Ia) wherein R1 is methyl; R2 is chloro; R3 is CH(CH3)2; X is oxygen; Y is sulphur, n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE N14

[0969] Table N14 provides 352 compounds of formula (Ia) wherein R1 is methyl; R2 is bromo; R3 is CH(CH3)2; X is oxygen; Y is sulphur; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE N15

[0970] Table N15 provides 352 compounds of formula (Ia) wherein R1 is methyl; R2 is cyano; R3 is CH(CH3)2; X is oxygen; Y is sulphur; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE N16

[0971] Table N16 provides 352 compounds of formula (Ia) wherein R1 is ethyl; R2 is hydrogen; R3 is CH(CH3)2; X is oxygen; Y is sulphur; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE N17

[0972] Table N17 provides 352 compounds of formula (Ia) wherein R1 is ethyl; R2 is fluoro; R3 is CH(CH3)2; X is oxygen; Y is sulphur; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE N18

[0973] Table N18 provides 352 compounds of formula (Ia) wherein R1 is ethyl; R2 is chloro; R3 is CH(CH3)2; X is oxygen; Y is sulphur, n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE N19

[0974] Table N19 provides 352 compounds of formula (Ia) wherein R1 is ethyl; R2 is bromo; R3 is CH(CH3)2; X is oxygen; Y is sulphur; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE N20

[0975] Table N20 provides 352 compounds of formula (Ia) wherein R1 is ethyl; R2 is cyano; R3 is CH(CH3)2; X is oxygen; Y is sulphur, n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE N21

[0976] Table N21 provides 352 compounds of formula (Ib) wherein R1 is methyl; R2 is hydrogen; R3 is CH(CH3)2; X and Y are each oxygen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE N22

[0977] Table N22 provides 352 compounds of formula (Ib) wherein R1 is methyl; R2 is fluoro; R3 is CH(CH3)2; X and Y are each oxygen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE N23

[0978] Table N23 provides 352 compounds of formula (Ib) wherein R1 is methyl; R2 is chloro; R3 is CH(CH3)2; X and Y are each oxygen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE N24

[0979] Table N24 provides 352 compounds of formula (Ib) wherein R1 is methyl; R2 is bromo; R3 is CH(CH3)2; X and Y are each oxygen; n is 0; and the values of R1 match those of the correspondingly numbered compounds of Table A1.

TABLE N25

[0980] Table N25 provides 352 compounds of formula (Ib) wherein R1 is methyl; R2 is cyano; R3 is CH(CH3)2; X and Y are each oxygen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE N26

[0981] Table N26 provides 352 compounds of formula (Ib) wherein R1 is ethyl; R2 is hydrogen; R3 is CH(CH3)2; X and Y are each oxygen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE N27

[0982] Table N27 provides 352 compounds of formula (Ib) wherein R1 is ethyl; R2 is fluoro; R3 is CH(CH3)2; X and Y are each oxygen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE N28

[0983] Table N28 provides 352 compounds of formula (Ib) wherein R1 is ethyl; R2 is chloro; R3 is CH(CH3)2; X and Y are each oxygen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE N29

[0984] Table N29 provides 352 compounds of formula (Ib) wherein R1 is ethyl; R2 is bromo; R3 is CH(CH3)2; X and Y are each oxygen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE N30

[0985] Table N30 provides 352 compounds of formula (Ib) wherein R1 is ethyl; R2 is cyano; R3 is CH(CH3)2; X and Y are each oxygen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE N31

[0986] Table N31 provides 352 compounds of formula (Ib) wherein R1 is methyl; R2 is hydrogen; R3 is CH(CH3)2; X is oxygen; Y is sulphur; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE N32

[0987] Table N32 provides 352 compounds of formula (Ib) wherein R1 is methyl; R2 is fluoro; R3 is CH(CH3)2; X is oxygen; Y is sulphur; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE N33

[0988] Table N33 provides 352 compounds of formula (Ib) wherein R1 is methyl; R2 is chloro; R3 is CH(CH3)2; X is oxygen; Y is sulphur, n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE N34

[0989] Table N34 provides 352 compounds of formula-(b) wherein R1 is methyl; R2is bromo; R3 is CH(CH3)2; X is oxygen; Y is sulphur; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE N35

[0990] Table N35 provides 352 compounds of formula (Ib)wherein R1 is methyl; R2 is cyano; R3 is CH(CH3)2; X is oxygen; Y is sulphur, n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE N36

[0991] Table N36 provides 352 compounds of formula (Ib) wherein R1 is ethyl; R2 is hydrogen; R3 is CH(CH3)2; X is oxygen; Y is sulphur; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE N37

[0992] Table N37 provides 352 compounds of formula (Ib) wherein R1 is ethyl; R2 is fluoro; R3 is CH(CH3)2; X is oxygen; Y is sulphur; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE N38

[0993] Table N38 provides 352 compounds of formula (Ib) wherein R1 is ethyl; R2 is chloro; R3 is CH(CH3)2; X is oxygen; Y is sulphur; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE N39

[0994] Table N39 provides 352 compounds of formula (Ib) wherein R1 is ethyl; R2 is bromo; R3 is CH(CH3)2; X is oxygen; Y is sulphur; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE N40

[0995] Table N40 provides 352 compounds of formula (Ib) wherein R1 is ethyl; R2 is cyano; R3 is CH(CH3)2; X is oxygen; Y is sulphur; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE N41

[0996] Table N41 provides 352 compounds of formula (Ib) wherein R1 is methyl; R2 is hydrogen; R3 is CH(CH3)2; X is oxygen; Y is NR7; R7 is hydrogen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE N42

[0997] Table N42 provides 352 compounds of formula (Ib) wherein R1 is methyl; R2 is fluoro; R3 is CH(CH3)2; X is oxygen; Y is NR7; R7 is hydrogen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE N43

[0998] Table N43 provides 352 compounds of formula (Ib) wherein R1 is methyl; R2 is chloro; R3 is CH(CH3)2; X is oxygen; Y is NR7; R7 is hydrogen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE N44

[0999] Table N44 provides 352 compounds of formula (ab) wherein R1 is methyl; R2 is bromo; R3 is CH(CH3)2; X is oxygen; Y is NR7; R1 is hydrogen; n is 0; and the values-of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE N45

[1000] Table N45 provides 352 compounds of formula (Ib) wherein R1 is methyl; R2 is cyano; R3 is CH(CH3)2; X is oxygen; Y is NR7; R1 is hydrogen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE N46

[1001] Table N46 provides 352 compounds of formula (Ib) wherein R1 is ethyl; R2 is hydrogen; R3 is CH(CH3)2; X is oxygen; Y is NR7; R7 is hydrogen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE N47

[1002] Table N47 provides 352 compounds of formula (Ib) wherein R1 is ethyl; R2 is fluoro; R3 is CH(CH3)2; X is oxygen; Y is NR7; R7 is hydrogen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE N48

[1003] Table N49 provides 352 compounds of formula (Ib) wherein R1 is ethyl; R2 is chloro; R3 is CH(CH3)2; X is oxygen; Y is NR7; R7 is hydrogen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE N49

[1004] Table N49 provides 352 compounds of formula (Ib) wherein R1 is ethyl; R2 is bromo; R3 is CH(CH3)2; X is oxygen; Y is NR7; R7 is hydrogen; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE N50

[1005] Table N50 provides 352 compounds of formula (Ib) wherein R1 is ethyl; R2 is cyano; R3 is CH(CH3); X is oxygen; Y is NR7; R7 is hydrogen; n is 0; and the values of 4 match those of the correspondingly numbered compounds of Table A1.

TABLE N51

[1006] Table N51 provides 352 compounds of formula (Ib) wherein R1 is methyl; R2 is hydrogen; R3 is CH(CH3)2; X is oxygen; Y is NR7; R1 is methyl; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE N52

[1007] Table N52 provides 352 compounds of formula (Ib) wherein R1 is methyl; R2 is fluoro; R3 is CH(CH3)2; X is oxygen; Y is NR7; R7 is methyl; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE N53

[1008] Table N53 provides 352 compounds of formula (Ib) wherein R1 is methyl; R2 is chloro; R3 is CH(CH3)2; X is oxygen; Y is NR7; R7 is methyl; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE N54

[1009] Table N54 provides 352 compounds of formula (Ib) wherein R1 is methyl; R2 is bromo; R3 is CH(CH3)2; X is oxygen; Y is NR7; R7 is methyl; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE N55

[1010] Table N55 provides 352 compounds of formula (Ib) wherein R1 is methyl; R2 is cyano; R3 is CH(CH3)2; X is oxygen; Y is NR7; R1 is methyl; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE N56

[1011] Table N56 provides 352 compounds of formula (Ib) wherein R1 is ethyl; R2 is hydrogen; R3 is CH(CH3)2; X is oxygen; Y is NR7; R3 is methyl; n is 0; and the values of 4 match those of the correspondingly numbered compounds of Table A1.

TABLE N57

[1012] Table N57 provides 352 compounds of formula (Ib) wherein R1 is ethyl; R2 is fluoro; R3 is CH(CH3)2; X is oxygen; Y is NR7; R1 is methyl; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE N58

[1013] Table N58 provides 352 compounds of formula (Ib) wherein R1 is ethyl; R2 is chloro; R3 is CH(CH3)2; X is oxygen; Y is NR7; R7 is methyl; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE N59

[1014] Table N59 provides 352 compounds of formula (Ib) wherein R1 is ethyl; R2 is bromo; R3 is CH(CH3)2; X is oxygen; Y is NR7; R7 is methyl; n is 0; and the values of R1 match those of the correspondingly numbered coinpounds of Table A1.

TABLE N60

[1015] Table N60 provides 352 compounds of formula (Ib) wherein R1 is ethyl; R1 is cyano; R3 is CH(CH3)2; X is oxygen; Y is NR7; R1 is methyl; n is 0; and the values of R1 match those of the correspondingly numbered compounds of Table A1.

TABLE N61

[1016] Table N61 provides 352 compounds of formula (Ia) wherein R1 is methyl; R1 is hydrogen; R3is CH(CH3)2; X is oxygen; Y is NR7; R1 is methyl; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE N62

[1017] Table N62 provides 352 compounds of formula (Ia) wherein R1 is methyl; R2 is fluoro; R3is CH(CH3)2; X is oxygen; Y is NR7; R7 is methyl; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE N63

[1018] Table N63 provides 3 52 compounds of formula (Ia) wherein R1 is methyl; R2 is chloro; R3 is CH(CH3)2; X is oxygen; Y is NR7; R7 is methyl; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE N64

[1019] Table N64 provides 3 52 compounds of formula (Ia) wherein R1 is methyl; R2 is bromo; R3 is CH(CH3)2; X is oxygen; Y is NR7; R7 is methyl; n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE N65

[1020] Table N65 provides 352 compounds of formula (Ib) wherein R1 is methyl; R2 is cyano; R3 is CH(CH3)2; X is oxygen;, Y is NR7; R7 is methyl;, n is 0; and the values of R4 match those of the correspondingly numbered compounds of Table A1.

TABLE N66

[1021] 2 mp = melting point ppm = parts per million s = singlet b = broad d = doublet dd = doublet of doublets t = triplet q = quartet m = multiplet JAB = coupling constant between atom A and atom B

[1022] 3 TABLE W Compound Melting NMR proton shifts (/ppm) No (Table No) point (/° C.) (CDCl3 unless otherwise stated.) 15 (A1) 130-131 2.3(s,3H); 2.8(s,2H); 3.9(s,2H); 6.5(s,1H); 7.25(dd,1H); 7.5(d,1H); 7.6(d,1H); 8.9(b,1H). 1 (A3) 164-165 2.4(s,3H); 4.0(s,2H); 7.4(dd,1H); 7.65(d,1H); 7.8(d,1H); 8.1(b,1H); 8.15(s,1H). 2 (A3) 161-163 2.35(s,3H); 2.7(s,3H); 3.9(s,2H); 7.3(m,1H); 7.5(d,1H); 7.6(d,1H); 8.05(b,1H). 3 (A3) 169-171 1.45(t,3H); 2.35(s,3H); 3.0(q,2H); 4.0(s,2H); 7.25(dd,1H); 7.5(d,1H); 7.6(d,1H); 8.1(b,1H). 4 (A3) 153-155 1.05(t,3H); 1.9(m,2H); 2.35(s,3H); 3.95(t,2H), 4.0(s,2H); 7.35(dd,1H). 5 (A3) 146-147 0.98(t,3H); 1.5(m,2H); 1.9(m,2H); 2.4(s,3H); 2.95(t,2H); 4.0(s,2H); 7.3(dd,1H); 7.5(d,1H); 7.65(d,1H); 8.05(b,1H). 8 (A3) 167-168 1.45(d,6H); 2.35(s,3H); 3.25(m,1H); 3.95(s,2H); 7.25(dd,1H); 7.5(d,1H); 7.6(d,1H); 8.1(b,1H). 9 (A3) 144-145 1.5(s,9H); 2.35(s,3H); 4.0(s,2H);, 7.3(dd,1H); 7.55(d,1H); 7.65(d,1H); 8.1(b,1H). 10 (A3) 136-137 0.95(t,3H); 1.45(d,3H); 1.9(m;2H); 2.4(s,3H); 3.1(m,1H); 4.0(s,2H); 7.3(dd,1H); 7.55(d,1H): 7.65(s,1H); 8.1(b,1H). 12 (A3) 84-86 0.9(t,3H); 1.4(m,2H); 1.45(d,3H); 1.7(m,1H); 1.9(m,1H); 2.4(d,2H); 3.15(m,1H); 4.0(s,2H); 7.3(dd,1H); 7.5(d,1H); 7.65(d,1H); 8.2(b,1H). 13 (A3) 127-129 0.9(m,6H); 1.85(m,4H); 2435(s,3H); 2.9(m,1H); 4.0(s,2H); 7.25(dd,1H); 7.55(d,1H);7.65(d,H); 8.15(b,1H). 14 (A3) 118-119 1.05(d,6H); 2.3(m,1H); 2.4(s,3H); 2.8(d,2H); 3.95(s,2H); 7.25(dd,1H); 7.5(d,1H); 7.6(d,1H); 8.1(b,1H). 15 (A3) 144-145 1.1(s,9H);2.35(s,3H); 2.85(s,2H); 3.95(s,2H); 7.25(dd,1H); 7.55(d,1H); 7.65(d,1H); 8.1(b,1H). 21 (A3) 193-194 1.25(m,4H); 2.2(m,1H); 2.35(s,3H); 4.0(s,2H); 7.2(dd,1H); 7.5(d,1H); 7.55(d,1H); 8.1(b,1H). 28 (A3) 158-159 1.8(m,4H); 2.1(m,4H); 2.4(s,3H); 3.4(m,1H); 4.0(s,3H); 7.25(dd,1H); 7.5(d,1H); 7.6(d,1H); 8.1(b,1H). 35 (A3) 144-146 1.4(m,3H); 1.7(m,3H); 1.9(m,2H); 2.2(m,2H); 2.4(s,3H); 3.0(m,1H); 4.0(s,2H); 7.3(dd,1H); 7.5(d,1H); 7.6(d,1H); 8.1(b,1H). 36 (A3) 140-141 1.2(s,3H); 1.3(m,2H); 1.55(m,4H); 2.15(m,2H); 2.3(m,2H); 2.4(s,3H); 4.0(s,2H); 7.3(dd,1H); 7.5(d,1H); 7.65(d,1H); 8.15(b,1H). 41 (A3) 165-167 0.35(m,2H); 0.65(m,2H); 1.25(m,1H); 2.4(s,3H); 2.9(d,2H); 4.0(s,2H); 7.3(dd,1H); 7.55(d,1H); 7.65(d,1H); 8.1(b,1H). 42 (A3) 118-119 1.3(m,2H); 1.7(m,4H); 1.9(m,2H); 2.4(s,3H); 2.5(m,1H); 2.95(d,2H); 4.0(s,2H); 7.3(dd,1H); 7.5(d,1H); 7.6(d,1H); 8.1(b,1H). 45 (A3) 176-178 2.05(m,3H); 2.35(s,3H); 4.0(s,2H); 6.5(dd,1H); 7.1(m,1H); 7.3(dd,1H); 7.5(d,1H); 7.65(dd,1H); 8.1(b,1H). 46(A3) 145-147 2.05(s,3H); 2.35(s,3H); 2.36(s,3H); 4.0(s,2H); 6.25(m,1H); 7.25(dd,1H); 7.5(d,1H); 7.65(d,1H); 8.1(b,1H). 47(A3) 151-152 1.95(dd,3H); 2.2(d,3H); 2.35(s,3H); 3.95(s,2H); 7.0(m,1H); 7.25(dd,1H); 7.5(d,1H); 7.65(d,1H); 8.05(b,1H). 63(A3) 209-210 (CDCl3/d6-DMSO): 2.35(s,3H); 4.05(s,2H); 7.2(d,1H); 7.4(dd,1H); 7.55(d,1H); 7.8(m,4H); 8.3(d,2H). 73(A3) 146-147 2.4(s,3H); 4.0(s,2H); 5.6(d,2H,JHf = 7Hz); 7.4(dd,1H); 7.6(d,1H); 7.75(d,1H); 8.1(b,1H). 75(A3) 187-188 2.4(s,3H); 4.0(s,2H); 7.5(dd,1H); 7.7(d,1H); 7.85(d,1H); 8.1(b,1H). 79(A3) 128-129 2.4(s,1H); 4.0(s,2H); 6.3(m,1H); 7.5(dd,1H); 7.7(d,1H); 7.85(d,1H); 8.15(b,1H). 80(A3) 141-142 2.4(s,3H); 4.05(s,2H); 7.55(dd,1H); 7.7(d,1H); 7.9(d,1H); 8.15(b,1H). 86(A3) 2.4(s,3H); 4.0(s,3H); 7.5(dd,1H); 7.7(d,1H); 7.9(d,1H); 8.2(b,1H). 93(A3) 183-185 2.05(d,3H); 2.4(s,3H); 4.0(s,2H); 5.25(q,1H), 7.4(dd,1H); 7.6(d,1H); 7.7(d,1H); 8.1(b,1H). 95(A3) 163-164 1.1(t,3H); 2.4(m,2H); 2.4(s,3H); 4.0(s,2H); 5.0(t,1H); 7.4(dd,1H); 7.6(d,1H); 7.7(dd,1H); 8.1(b,1H). 98(A3) 130-131 1.6(s,6H); 2.35(s,3H); 3.9(s,2H); 4.0(s,2H); 7.3(dd,1H); 7.6(d,1H); 7.7(d,1H); 8.1(b,1H). 103(A3) 165-167 2.4(s,3H); 4.0(s,2H); 7.5(dd,1H); 7.7(d,1H); 7.8(d,1H); 8.1(b,1H). 113(A3) 192-194 2.4(s,3H); 4.0(s,2H); 4.15(s,2H); 7.4(dd,1H); 7.6(d,1H); 7.7(dd,1H); 8.1(b,1H). H5(A3) 165-166 1.9(d,3H); 2.4(s,3H); 4.0(s,2H); 4.3(q,1H); 7.4(dd,1H); 7.6(d,1H); 7.7(d,1H); 8.1(b,1H). 130(A3) 124-125 2.35(s,3H); 3.55(s,3H); 4.0(s,2H); 4.75(s,2H); 7.35(dd,1H); 7.6(d,1H); 7.7(d,1H); 8.1(b,1H). 140(A3) 126-129 2.4(s,3H); 4.0(s,2H); 5.35(s,2H); 7.05(m,3H); 7.35(m,3H); 7.6(d,1H); 7.7(d,1H); 8.13(b,1H). 172(A3) 123-124 2.2(s,3H); 2.4(s,3H); 3.05(m,2H); 3.3(m,2H); 4.0(s,3H); 7.3(dd,1H); 7.55(d,1H); 7.65(d,1H); 8.1(b,1H). 173(A3) 163-164 2.4(s,3H); 4.0(s,2H); 4.3(s,2H); 7.3(m,4H); 7.45(m,2H); 7.55(d,1H); 7.6(d,1H); 8.1(b,1H). 174(A3) 147-148 2.4(s,3H); 4.0(s,2H); 7.35(dd,1H); 7.55(d,1H); 7.65(d,1H); 8.1(b,1H). 180(A3) 151-153 1.3(t,3H); 2.35(s,3H); 3.2(s,3H); 3.6(q,2H), 3.9(s,3H); 6.9(dd,1H); 7.25(m,2H); 8.1(b,1H). 183(A3) 181-183 1.5(s,9H); 2.35(s,3H); 3.9(s,2H); 5.0(b,1H); 6.95(dd,1H); 7.25(s,1H); 7.3(dd,1H); 8.1(b.1H). 191(A3) 172-173 2.4(s,3H); 3.7(m,4H); 3.85(m,4H); 3.9(s,2H); 7.0(dd,1H); 7.3(m,2H); 8.1(b,1H). 203(A3) 151-152 2.4(s,3H); 3.95(s,2H); 4.2(s,3H); 7.15(dd,1H); 7.4(d,1H); 7.45(d,1H), 8.05(b,1H). 204(A3) 130-131 1.5(t,3H); 2.4(s,3H); 3.95(s,2H); 4.6(q,2H); 7.1(dd,1H); 7.4(m,2H); 8.05(b,1H). 206(A3) 158-159 1.5(d,6H); 2.4(s,3H); 3.9(s,2H); 5.3(m,1H); 7.1(dd,1H); 7.38(d,1H); 7.4(d,1H); 8.1(b,1H). 220(A3) 152-154 2.4(s,3H); 2.8(s,3H); 3.95(s,2H); 7.2(dd,1H); 7.5(d,1H); 7.55(d,1H); 8.05(b,1H). 221(A3) 148-149 1.5(t,3H); 2.4(s,3H); 3.35(q,2H); 3.95(s,2H); 7.2(dd,1H); 7.5(d,1H); 7.6(dd,1H); 8.05(b,1H). 223(A3) 113-115 1.5(d,6H); 2.35(s,3H); 3.9(s,2H); 4.05(m,1H); 7.2(dd,1H); 7.45(d,1H); 7.65(d,1H); 8.1(b,1H). 224(A3) 101-102 1.2(s,9H); 2.4(s,3H); 3.95(s,2H); 7.25(dd,1H); 7.5(d,1H); 7.6(d,1H); 8.1(b,1H). 228(A3) 203-205 2.25(s,3H); 4.0(s,2H); 4.45(s,2H); 7.3(dd,1H); 7.6(b,2H); 11.75(s,1H). 229(A3) 149-150 2.4(s,3H); 3.8(s,3H); 4.0(s,2H); 4.15(s,2H); 7.2(dd,1H); 7.5(d,1H); 7.55(d,1H); 8.05(b,1H). 239(A3) 201-202 2.35(s,3H); 4.0(s,2H); 4.4(s,2H); 7.3(dd,1H); 7.55(d,1H); 7.6(d,1H); 8.1(b,1H). 244(A3) 196-197 2.4(s,3H); 4.0(s,2H); 4.7(s,2H); 7.3(dd,1H); 7.55(d,1H); 7.6(d,1H); 7.65(s,2H); 8.05(b,1H). 246(A3) 75-77 2.4(s,3H); 3.95(s,2H); 5.8(s,1H); 7.3(m,11H); 7.5(d,1H); 7.7(d,1H); 8.3(b,1H). 247(A3) 114-115 2.4(s,3H); 3.25(m,4H); 4.0(s,2H); 7.25(m,6H); 7.5(d,1H); 7.65(d,1H); 8.1(b,1H). 248(A3) 208-209 2.4(s,3H); 4.0(s,2H); 7.3(dd,1H); 7.5(m,3H); 7.6(d,1H); 7.7(d,1H); 8.15(b,1H); 8.25(m,2H). 252(A3) 152-153 1.35(s,9H); 2.35(s,3H); 4.0(s,2H); 7.3(dd,1H); 7.55(d,2H); 7.6(d,1H); 7.7(d,1H); 8.1(b,1H); 8.2(d,2H). 253(A3) 175-176 2.4(s,3H); 4.0(s,2H); 7.45(m,3H); 7.6(dd,1H); 7.7(d,1H); 7.8(d,1H); 8.1(b,H); 8.2(m,1H). 257(A3) 189-191 2.4(s,3H); 4.0(s,2H); 7.4(m,2H); 7.6(d,1H); 7.65(dd,1H); 7.8(d,1H); 8.1(b,1H); 8.15(d,1H). 261(A3) 216-217 2.4(s,3H); 4.0(s,2H); 7.4(dd,1H); 7.5(m,1H); 7.65(d,1H); 7.75(d,1H); 8.1(b,1H); 8.15(d,2H). 267(A3) 2.4(s,3H); 4.05(s,2H); 7.45(dd,1H); 7.7(d,1H); 7.85(d,1H); 8.1(b,1H); 8.8(m,1H); 8.45(m,2H). 272(A3) 212-214 (CDCl3/d6-DMSO): 2.4(s,3H); 4.1(s,2H); 7.3(m,2H); 7.4(dd,1H); 7.55(m,1H); 7.6(d,1H); 7.8(d,1H); 8. 1(m,1H); 10.4(b,1H). 278(A3) 2.4(s,3H); 4.05(s,2H); 7.15(m,2H); 7.4(dd,1H); 7.5(m,1H); 7.7(d,1H); 7.85(d,1H); 8.12(b,1H). 287(A3) 215-216 2.4(s,3H); 4.05(s,2H); 7.45(dd,1H); 7.7(d,1H); 7.85(d,1H); 8.1(b,1H). 305(A3) 184-185 2.4(s,3H); 3.95(s,3H); 4.0(s,2H); 7.1(m,1H); 7.35(m.1H); 7.45(t,1H); 7.65(d,1H); 7.75(d,1H); 7.8(m,1H); 7.85(m,1H); 8.1(b,1H). 307(A3) 211-212 2.4(s,3H); 3.9(s,3H); 4.0(s,2H); 7.05(m,2H); 7.3(dd,1H); 7.6(d,1H); 7.2(d,1H); 8.1(b,1H); 8.2(m,2H). 329(A3) 255-256 2.4(s,3H); 3.95(s,3H); 4.0(s,2H); 7.4(dd,1H); 7.65(d,1H); 7.75(d,1H); 8.1(1,1H); 8.2(d,2H); 8.3(d,2H). 330(A3) 181-183 2.4(s,3H); 4.0(s,2H); 7.2(m,1H); 7.3(dd,1H); 7.6(m,2H); 7.7(d,1H); 7.9(m,1H); 8.1(b,1H). 331(A3) 193-194 2.4(s,3H); 4.0(s,2H); 7.1(d,1H); 7.35(dd,1H); 7.53(d,1H); 7.65(d,1H); 7.75(d,1H); 8.1(b,1H). 334(A3) 143-144 2.4(s,3H); 4.0(s,2H); 4.5(s,2H); 7/0(m,1H); 7.05(m,1H); 7.25(m,1H); 7.3(dd,1H); 7.55(d,1H); 7.65(d,1H); 8.1(b,1H). 339(A3) 245 (CDCl3/d6-DMSO): 2.4(s,3H); 4.1(s,2H); 7.45(dd,1H); 7.6(d,1H); 7.8(d,1H); 8.1(m,2H); 8.8(m,2H); 10.6(b,1H). 343(A3) 183-184 2.4(s,3H); 4.0(s,2H); 7.4(dd,1H); 7.45(m,1H); 7.7(d,1H); 7.8(d,1H); 8.1(b,1H); 8.5(m,1H); 8.6(m,1H). 349(A3) 171-173 2.4(s,3H); 4.05(s,2H); 7.15(d,1H); 7.5(dd,1H); 7.7(d,1H); 7.8(d,1H); 8.2(b,1H); 8.5(d,1H). 351(A3) (CDCl3/d6DMSO): 2.25(s,3H); 3.9(s,2H); 6.95(m,2H); 7.15(d,1H); 11.55(s,1H). 352(A3) (CDCl3/d6-DMSO); 2.4(s,3H); 3.95(s,2H); 7.2(m,3H); 10.9(s,1H); 13.4(s,1H). 2(A4) 156-157 2.4(s,3H); 2.7(s,3H); 4.0(s,2H); 7.25(dd,1H); 7.5(d,1H); 7.6(d,1H); 8.1(b,1H). 15(A4) 115-117 1.1(s,9H); 2.45(s,3H); 2.9(s,2H); 4.1(s,2H), 7.35(dd,1H); 7.55(d,1H); 7.7(d,1H); 8.75(b,1H). 2(A5) 213-214 2.5(s,3H); 2.65(s,3H); 4.0(s,2H); 7.3(dd,1H); 7.5(d,1H); 7.6(d,1H); 9.7(b,1H); 15(A5) 134-135 1.1(s,9H); 2.5(s,3H); 2.8(s,2H); 4.0(s,2H); 7.3(dd,1H); 7.5(d,1H); 7.65(d,1H); 9.8(b,1H). 2(A8) 165-167 1.25(t,3H); 2.7(s,3H); 2.7(q,2H); 4.0(s,2H); 7.25(dd,1H); 7.5(d,1H); 7.6(d,1H); 8.1(b,81H). 15(A8) 126-127 1.1(s,9H); 1.3(t,3H); 2.7(q,2H); 2.8(s,2H); 4.0(s,2H); 7.3(dd,1H); 7.5(d,1H); 7.65(d,1H); 8.1(b,1H). 2(A13) 160-164 2.35(s,3H); 2.85(s,3H); 4.0(s,2H); 7.35(dd,1H); 7.9(m,2H); 8.15(bs,1H). 4(A13) gum 1.1(t,3H); 1.95(m,2H); 2.4(s,3H); 3.1(t,2H); 4.0(s,2H); 7.35(dd,1H); 7.85(d,1H); 7.9(d,1H); 8.3(b,1H). 8(A13) 134-136 1.5(d,6H); 2.35(s,3H); 3.5(m,1H); 4.0(s,2H); 7.35(dd,1H); 7.85(m,4H); 8.25(b,1H). 9(A13) gum 1.5(s,9H); 2.35(s,3H); 4.0(s,2H); 7.35(dd,1H); 7.9(d,1H); 7.95(s,1H); 8.15(b,1H). 15(A13) gum 1.1(s,9H); 2.35(s,3H); 2.95(t,2H); 4.0(s,2H); 7.35(dd,1H); 7.85(d,1H); 7.95(d,1H), 8.25(b,1H). 2(A23) 170-172 2.4(s,3H); 2.65(s,3H); 4.0(s,2H); 7.25(dd,1H); 7.5(d,1H); 7.7(b,1H) 8.1(b,1H). 4(A23) 95-97 1.05(t,3H); 1.95(m,2H); 2.4(s,3H); 2.95(t,2H); 4.0(s,2H); 7.35(m,1H); 7.5(s,1H); 7.7(d,1H); 8.2(b,1H). 15(A23) gum 1.05(s,9H); 2.4(s,3H); 2.8(s,2H); 4.0(s,2H); 7.25(d,1H); 7.5(b,1H); 7.7(d,1H); 8.45(b,1H). 2(A43) (CDCl3/d6-DMSO): 2.3(s,3H); 2.6(s,3H); 4.0(s,2H); 7.15(d,1H); 7.5(m,2H); 9.3(b,1H). 4(A43) (CDCl3/d6-DMSO): 1.0(t,3H); 1.8(m,2H); 2.4(s,2H); 2.9(t,2H); 4.0(s,2H); 7.2(dd,1H); 7.5(d,1H); 7.6(d,1H). 9(A43) (CDCl3/d6-DMSO): 1.6(s,9H); 2.4(s,2H); 4.0(s,2H); 7.2(dd,1H); 7.55(b,2H). 15(A43) (CDCl3/d6-DMSO): 1.1(s,9H); 2.4(s,3H); 2.8(s,2H); 3.8(s,2H); 7.2(dd,1H); 7.5(b,1H); 7.6(b,1H). 248(A43) (CDCl3/d6-DMSO): 2.3(s,3H); 3.9(s,2H); 7.1(dd,1H); 7.45(m,4H); 7.55(m,1H); 8.1(m,2H); 8.75(b,1H). 2(B3) 97-98 2.5(s,3H); 2.6(s,3H); 3.3(b,3H); 3.7(b,2H); 7.05(b,1H); 7.35(b,2H). 4(B3) 75-76 1.05(t,3H); 1.9(m,2H); 2.5(s,3H); 2.9(t,2H); 3.25(b,3H); 3.65(b,2H); 7.05(b,1H); 7.4(b,2H). 15(B3) 80-90 (d6-DMSO): 1.0(s,9H); 2.3(s,3H); 2.75(s,2H); 3.4(s,3H); 3.85(s,2H); 7.1(dd,1H); 7.4(b,1H); 7.5(d,1H). 2(C3) gum 1.15(t,3H); 2.5(s,3H); 2.6(s,3H); 3.6(b,2H); 3.8(b,2H); 7.05(b,1H); 7.35(b,2H). 4(C3) gum 1.0(t,3H); 1.2(t,3H); 1.9(m,2H); 2.5(s,3H); 2.9(t,2H); 3.6(b,2H); 3.8(b,2H); 7.05(b,1H); 7.4(b,2H). 15(C3) 53-54 1.05(s,9H); 1.2(t,3H); 2.5(s,3H); 2.8(s,2H); 3.6(b,2H); 3.75(b,2H); 7.05(b,1H); 7.4(b,2H). 2(D3) gum 0.9(s,3H); 1.6(m,2H); 2.5(s,3H); 2.6(s,3H); 3.6(b,2H); 3.7(b,2H); 7.05(b,1H); 7.35(b,2H). 4(D3) gum 0.9(t,3H); 1.05(t,3H); 1.55(m,2H); 1.9(m,2H); 2.5(s,3H); 2.9(t,2H); 3.6(b,2H); 3.7(b,2H), 7.05(b,1H); 7.35(b,2H). 15(D3) gum 0.9(t,3H); 1.05(s,9H); 1.55(m,2H); 2.5(s,3H); 2.8(s,3H); 3.65(m,4H); 7.05(b,1H); 7.35(b,2H). 2(E3) gum 2.5(s,3H); 2.6(s,3H); 3.65(b,2H); 4.3(b,2H); 5.2(b,2H); 5.8(b,1H); 7.05(b,1H); 7.35(b,2H). 4(E3) gum 1.05(t,3H); 1.9(m,2H); 2.5(s,3H); 2.9(t,2H); 3.65(b,2H); 4.3(b,2H); 5.2(b,2H); 5.8(b,1H); 7.05(b,1H); 7.4(b,2H). 15(E3) gum 1.1(s,9H); 2.5(s,3H); 2.8(s,2H); 3.7(b,2H); 4.3(b,2H); 5.2(b,2H); 5.8(b,1H); 7.05(b,1H); 7.4(b,2H). 2(F3) gum 2.3(b,1H); 2.5(s,3H); 2.6(s,3H); 3.65(b,2H); 4.5(b,2H); 7.05(b,1H); 7.35(b,2H). 4(F3) gum 1.05(t,3H); 1.9(m,2H); 2.3(b,1H); 2.5(s,3H); 2.9(t,2H); 3.65(b,2H); 4.5(b,2H); 7.05(b,1H); 7.4(b,2H). 15(F3) gum 1.05(s,9H); 2.3(b,1H); 2.5(s,3H); 2.8(s,2H); 3.65(b,2H); 4.5(b,2H); 7.05(b,1H); 7.4(b,2H). 15(H3) 93-95 1.05(s,9H); 2.5(s,3H); 2.8(s,2H); 3.7(s,2H); 4.3(b,2H); 7.0(dd,1H); 7.3(b,1H); 7.4(b,1H). 2(K3) gum 2.5(s,3H); 2.6(s,3H); 3.4(s,3H); 3.5(m,2H); 3.7(b,2H); 3.75(m,2H); 5.15(b,2H); 7.05(b,1H); 7.4(b,2H). 4(K3) gum 1.05(t,3H); 1.9(m,2H); 2.5(s,3H); 2.9(t,2H); 3.35(s,3H); 3.5(m,2H); 3.7(b,2H); 3.75(m,2H); 5.1 5(b,2H); 7.05(b,1H); 7.4(b,2H). 15(K3) gum 1.05(s,9H); 2.5(s,3H); 2.8(s,2H); 3.35(s,3H); 3.5(m,2H); 3.7(b,2H); 3.75(m,2H); 5.15(b,2H); 7.05(b,1H); 7.4(b,2H). 2(L3) gum 1.2(t,3H); 2.5(s,3H); 2.6(s,3H); 3.6(q,2H); 3.7(b,2H); 5.1(b,2H); 7.05(b,1H); 7.4(b,2H). 4(L3) gum 1.05(t,3H); 1.2(t,3H); 1.9(m,2H); 2.5(s,3H); 2.9(t,2H); 3.6(q,2H); 3.7(b,2H); 5.1(b,2H); 7.05(b,1H); 7.4(b,2H). 15(L3) gum 1.05(s,9H); 1.2(t,3H); 2.5(s,3H); 2.8(s,2H); 3.6(q,2H); 3.7(b,2H); 5.1(b,2H); 7.05(b,1H); 7.4(b,2H). 2(M3) gum 2.5(s,3H); 2.6(s,3H); 3.4(s,3H); 3.5(m,2H); 3.7(b,2H); 3.75(m,2H); 5.15(b,2H); 7.05(b,1H); 7.4(b,2H). 4(M3) gum 1.05(t,3H); 1.9(m,2H); 2.5(s,3H); 2.9(t,2H); 3.35(s,3H); 7.4(b,2H). 15(M3) gum 1.05(s,9H); 2.5(s,3H); 2.8(s,2H); 3.35(s,3H); 3.5(m,2H); 3.7(b,2H); 3.75(m,2H); 5.15(b,2H); 7.05(b,1H); 7.4(b,2H). 15(N3) 80-81 1.0(b,3H); 1.05(s,9H); 1.2(b,3H); 2.5(s,3H); 2.8(s,2H); 3.55(b,2H); 5.0(m,1H); 7.05(b,1H); 7.4(m,2H). 15(V3) 160-161 1.1(s,9H); 2.4(s,3H); 2.85(s,2H); 4.4(s,2H); 7.3(dd,1H); 7.6(d,1H); 7.7(d,1H); 9.3(b,1H)

[1023] 4 Registered Trade Mark Composition SYNPERONIC NP8 } Nonylphenol-ethylene oxide condensate SYNPERONIC NP13 } SYNPERONIC A7 Synthetic primary alcohol-ethylene oxide condensate AROMASOL H Alkylbenzene solvent SOLVESSO 200 Inert organic diluent KELTROL Polysaceharide PROXEL Bactericide

[1024] 4 5 % by weight Compound No. 4 (Table A23) 25.0 SYNPERONIC NP13 2.5 Calcium dodecylbenzenesulphonate 2.5 AROMASOL H 70.0

[1025] 6 % by weight Compound No. 272 (Table A3) 25.0 Silica 25.0 Sodium lignosulphonate 5.0 Sodium lauryl sulphate 2.0 Kaolin 43.0

[1026] 7 % by weight Compound No. 4 (Table K3) 1.0 Talc 99.0

[1027] 8 % by weight Compound No. 2 (Table D3) 10.0 SOLVESSO 200 90.0

[1028] 9 % by weight Compound No. 15 (Table H3) 10.0 AROMASOL H 10.0 Toluene di-isocyanate 3.0 SYNPERONIC A7 1.0 Polyvinyl alcohol 2.0 Bentonite 1.5 KELTROL 0.1 Water 72.4

[1029] 10 % by weight Compound No. 251 (Table A43) 0.5 SOLVESSO 200 0.2 SYNPERONIC A7 0.1 Calcium carbonate granules (diameter 0.3-0.7 mm) 99.2

[1030] 11 % by weight Compound No. 4 (Table E3) 0.5 Sodium lignosulphonate 5.0 Kaolin 94.5

[1031] 12 % by weight Compound No. 331 (Table A3) 25.0 Sodium lignosulphonate 3.0 Propylene glycol 10.0 Bentonite 2.0 KELTROL 0.1 PROXEL 0.1 Water 59.8

[1032] 13 % by weight Compound No. 343 (Table A3) 25.0 Silica 5.0 Sodium lignosulphonate 10.0 Sodium lauryl sulphate 5.0 Sodium acetate 10.0 Montmorillonite powder 45.0

[1033] 14 TABLE X1 Compound No. MUSCDO MUSCDO (Table No.) TETRUR MYZUPE AC AK HELIVI LAPHEG MELGIN 4 (A3) 5 9 9 9 9 5 9 15 (A3) 9 9 9 0 9 9 0 2 (A3) 0 9 0 0 5 0 5 9 (A3) 9 5 9 0 9 5 0 248 (A3) 0 0 0 0 5 0 0 257 (A3) 9 0 0 5 5 0 5 1 (A3) 0 5 0 0 0 0 5 8 (A3) 0 5 9 9 5 5 0 3 (A3) 5 9 9 9 9 5 0 140 (A3) 0 0 0 0 0 0 0 220 (A3) 0 5 5 0 0 0 0 14 (A3) 9 9 9 5 9 9 0 221 (A3) 0 9 9 5 0 0 0 223 (A3) 0 9 0 0 5 0 0 10 (A3) 0 9 5 0 5 5 0 252 (A3) 0 0 0 0 0 0 0 46 (A3) 5 9 5 5 0 5 0 13 (A3) 9 9 9 5 0 0 0 329 (A3) 0 0 0 0 0 0 N/T 47 (A3) 0 9 0 0 0 0 0 247 (A3) 0 9 0 0 0 0 0 331 (A3) 0 0 0 0 0 0 N/T 98 (A3) 9 9 5 0 5 5 0 45 (A3) 5 9 9 9 5 9 0 5 (A3) 0 9 0 0 5 5 0 28 (A3) 9 9 5 9 9 5 0 172 (A3) 9 9 5 9 5 5 5 261 (A3) 0 0 0 0 0 0 0 224 (A3) 9 9 0 0 5 0 0 351 (A3) 0 0 0 0 0 0 0 15 (B3) 9 5 0 0 0 0 0 15 (D3) 9 9 0 0 5 5 0 15 (K3) 9 9 0 0 5 5 0 15 (L3) 9 9 9 9 9 5 0 15 (M3) 9 9 0 0 0 5 0 15 (C3) 9 9 9 0 0 9 0 73 (A3) 0 9 0 0 5 0 0 41 (A3) 5 9 0 9 5 5 0 2 (A23) 0 0 0 0 0 0 0 4 (A23) 0 9 0 0 0 0 0 15 (A23) 9 5 0 0 0 5 0 2 (K3) 9 9 9 0 0 0 0 2 (B3) 0 0 9 0 0 0 0 4 (B3) 0 5 0 0 0 5 0 15 (F3) 9 9 0 0 9 9 0 2 (L3) 9 9 9 0 9 5 0 2 (M3) 0 5 0 0 0 0 0 4 (L3) 9 9 9 5 9 9 0 4 (K3) 0 5 0 0 0 5 0 15 (E3) 9 9 0 0 9 5 0 2 (C3) 9 5 9 0 0 5 0 4 (M3) 0 9 0 0 0 0 0 4 (C3) 9 9 0 5 0 9 0 352 (A3) 0 5 0 0 0 0 0 2 (E3) 0 0 0 0 0 0 0 2 (F3) 0 9 0 0 0 0 0 4 (F3) 5 9 0 5 0 9 0 4 (E3) 5 9 0 0 0 0 0 2 (D3) 0 0 0 0 0 0 0 4 (D3) 9 5 0 0 0 5 0 228 (A3) 0 0 0 0 0 0 0 2 (A13) 0 0 0 0 0 0 5 15 (V3) 9 5 0 0 0 0 0 180 (A3) 0 0 0 0 0 5 0 4 (A13) 9 9 9 9 0 N/T 0 183 (A3) 9 0 0 5 5 5 0 203 (A3) 0 9 9 9 0 0 0 174 (A3) 0 5 0 0 0 0 0 2 (A43) 0 0 0 0 0 0 5 229 (A3) 0 0 0 0 0 0 0 191 (A3) 9 0 5 5 5 0 9 15 (A1) 9 0 5 0 0 0 0 15 (A4) 9 9 9 9 0 9 0 204 (A3) 0 9 9 9 5 9 0 2 (A4) 0 5 5 5 0 N/T 0 9 (A43) 5 9 0 0 0 N/T 0 339 (A3) 9 0 0 0 0 N/T 0 35 (A3) 9 9 0 0 0 N/T 0 15 (N3) 0 0 0 0 0 N/T 0 113 (A3) 9 0 0 0 0 N/T 0 80 (A3) 0 0 0 0 0 N/T 0

[1034] 15 TABLE X2 Compound No. (Table No.) TETRUR MYZUPE HELIVI MELGIN 287 (A3) 0 0 0 0 15 (A5) 5 0 0 0 2 (A5) 0 5 0 5 2 (A8) 0 5 0 0 15 (A8) 9 9 5 0 330 (A3) 0 0 0 0 349 (A3) 0 0 0 0 173 (A3) 0 0 0 0 334 (A3) 0 0 0 0 272 (A3) 0 0 0 0 253 (A3) 0 5 0 0 42 (A3) 9 5 0 0 305 (A3) 0 0 0 0 86 (A3) 5 5 0 0 12 (A3) 5 5 0 9 93 (A3) 0 0 0 0 246 (A3) 0 0 0 0 36 (A3) 9 5 0 0 267 (A3) 0 5 0 0 79 (A3) 0 0 5 0 130 (A3) 5 9 0 0 95 (A3) 0 9 0 0 21 (A3) 0 5 0 0 343 (A3) 0 5 0 0 75 (A3) 0 9 0 0 15 (H3) 0 9 0 0 239 (A3) 0 9 0 0 244 (A3) 0 0 0 0 115 (A3) 0 5 0 0 Key to Tables X1 and X2: TETRUR = Tetranychus urticae MUSCDO AK = Musca domestica (kill) HELIVI = Hellothis virescens MELGIN = Meloidogyne incognita MYZUPE = Myzus persicae MUSCDO AC = Musca domestica (knockdown) LAPHEG = Spodoptera exigua N/T = Not tested

[1035] 16 0 = 0% disease present 1 = 0.1-1% disease present 3 = 1.1-3% disease present 5 = 3.1-5% disease present 10 = 5.1-10% disease present 20 = 10.1-20% disease present 30 = 20.1-30% disease present 60 = 30.1-60% disease present 90 = 60.1-100% disease present

[1036] 2 PRCO = 100 - { Banded ⁢ ⁢ mean ⁢ ⁢ disease ⁢ ⁢ level ⁢ ⁢ for ⁢ ⁢ treatment ⁢ ⁢ A Banded ⁢ ⁢ mean ⁢ ⁢ disease ⁢ ⁢ level ⁢ ⁢ on ⁢ ⁢ untreated ⁢ ⁢ controls } × 100 = 100 - ( 30 90 × 100 ) = 66.7 3 PRCO = 100 - { ⁢ Mean ⁢ ⁢ disease ⁢ ⁢ level ⁢ ⁢ for ⁢ ⁢ treatment ⁢ ⁢ A ⁢ Mean ⁢ ⁢ disease ⁢ ⁢ level ⁢ ⁢ on ⁢ ⁢ untreated ⁢ ⁢ controls } × 100 = 100 - ( 25 85 × 100 ) = 70.6 17 TABLE Y1 COMPOUND NO. ERYSGT ERYSGT PLASVI LEPTNO PUCCRT PHYTIN (TABLE NO.) 6 hr Prot/Folr 1 d Prot/Folr 1 d Prot/Folr 1 d Prot/Folr 1 d Prot/Folr 1 d Prot/Folr 4 (A3) 100* 34 50 100* 100* 15 (A3) 100* 100 71 100 100* 2 (A3) 100* 0* 21 100* 100* 9 (A3) 100* 100* 55 100 100 248 (A3) 0* 97* 0* 100* 17* 257 (A3) 0* 79* 0* 100* 0* 1 (A3) 88 6 59 100 8 (A3) 20 6 0 90 3 (A3) 4 14 33 98 140 (A3) 44 63 13 96 220 (A3) 12 6 17 100* 100* 14 (A3) 90 89 28 97 100 221 (A3) 50 84 20 99 99 223 (A3) 73 55 12 99 93 10 (A3) 98 87 28 100 100 252 (A3) 30 38 −13 97 46 (A3) 97 99 88 100 13 (A3) 100 100 58 100 93 329 (A3) 30 8 0 46 47 (A3) 86 92 63 99 247 (A3) 61 62 13 95 97 331 (A3) 33 49 17 95 98 (A3) 98 99 30 98 100 5 (A3) 40 39 30 88 100 28 (A3) 46 0 20 86 100 172 (A3) 40 44 10 96 100 261 (A3) 19 25 −7 3 0 224 (A3) 88 99 16 98 100 15 (B3) 75 79 −2 15 99 15 (D3) 55 70 25 99 15 (L3) 100 40 17 97 15 (M3) 6 98 15 (C3) 38 93 13 97 73 (A3) 93 57 100 100 41 (A3) 59 77 98 100 2 (A23) −3 53 77 100 4 (A23) 59 63 100 100 15 (A23) 62 83 98 100 2 (M3) 97 98 2 (B3) 96 100 4 (B3) 48 100 15 (F3) 95 100 2 (L3) 93 82 2 (M3) 68 83 4 (L3) 100 100 4 (K3) 100 98 15 (E3) 74 83 2 (C3) 74 50 4 (M3) 85 81 4 (C3) 96 79 352 (A3) 100 100 2 (E3) 99 98 2 (F3) 90 100 4 (F3) 100 99 4 (E3) 97 95 2 (D3) 96 59 4 (D3) 90 96 228 (A3) 6 66 2 (A13) 31 62 99 100 15 (V3) 87 −2 100 100 180 (A3) 29 14 69 4 (A13) 100 20 100 183 (A3) 99 19 99 100 203 (A3) 98 −3 100 85 2 (A43) 20 −3 7 18 229 (A3) 21 2 6 92 191 (A3) 94 36 99 92 15 (A1) 43 4 96 100 15 (A4) 91 19 99 100 204 (A3) 87 67 99 100 4 (A43) 0 31 0 15 (A43) 0 80 2 (A4) 97 −12 100 100 9 (A43) 7 −4 25 0 339 (A3) −7 0 31 0 35 (A3) 93 −15 100 84 15 (N3) 8 −2 3 3 113 (A3) 5 20 41 38 287 (A3) 34 −2 94 3 80 (A3) 99 −2 100 45 15 (A5) 15 −2 84 45 2 (A5) 18 −2 28 19 2 (A8) 54 9 100 74 15 (A8) 80 −2 99 63 (A3) 40 2 69 66 330 (A3) 87 37 99 99 173 (A3) 16 2 63 77 253 (A3) 94 94 8 99 98 42 (A3) 92 92 11 99 100 305 (A3) 16 16 −2 81 74 12 (A3) 95 17 100 100 93 (A3) 32 24 38 49 246 (A3) 16 27 13 79 36 (A3) 72 2 91 100 79 (A3) 100 14 100 130 (A3) 87 21 100 95 (A3) 68 8 100 21 (A3) 35 14 100 75 (A3) 90 27 94 15 (H3) 16 2 29 239 (A3) 23 3 244 (A3) 3 −2 84 115 (A3) −3 8 45

[1037] 18 TABLE Y2 COMPOUND NO. UNCINE PYRIOR RHIZSO VENTIN BOTRCI (TABLE NO.) 1 d Prot/Folr 1 d Prot/Folr 1 d Prot/Stem 1 d Prot/Folr 1 d Prot/Folr 4 (A3) 62 81 49 49 15 (A3) 100 100 5 100 73 2 (A3) 93 92 24 97 0 9 (A3) 100 100 29 83 3 248 (A3) 7 7 100 257 (A3) 61 11 0 1 (A3) 43 91 25 8 (A3) 40 0 26 3 (A3) 27 0 67 140 (A3) 99 0 70 220 (A3) −5 0 11 14 (A3) 98 90 12 10 221 (A3) 23 93 0 25 223 (A3) 30 63 0 60 10 (A3) 96 77 0 40 252 (A3) 79 46 0 −47 46 (A3) 100 92 0 84 13 (A3) 100 96 19 53 329 (A3) 6 38 0 −16 47 (A3) 98 88 0 37 247 (A3) 95 85 0 −11 331 (A3) 76 81 0 5 98 (A3) 100 81 96 5 (A3) 72 31 −10 28 (A3) 9 81 53 172 (A3) 36 19 69 261 (A3) 17 31 0 0 224 (A3) 91 91 0 60 351 (A3) 11 15 (B3) 100 69 29 5 15 (D3) 100 27 −14 15 (L3) 99 20 −21 15 (C3) 100 7 64 73 (A3) 93 100 0 41 (A3) 91 33 50 2 (A23) −17 47 89 4 (A23) 99 90 95 15 (A23) 100 80 0 100 2 (A13) 72 47 43 15 (V3) 100 100 0 10 180 (A3) 42 42 0 4 (A13) 100 100 55 183 (A3) 98 99 98 203 (A3) 69 96 65 2 (A43) 11 48 14 229 (A3) −9 55 10 191 (A3) 100 92 10 15 (A1) 100 87 54 15 (A4) 100 98 54 204 (A3) 81 96 22 4 (A43) 35 38 15 (A43) 63 63 2 (A4) 90 99 92 9 (A43) 7 26 38 339 (A3) 26 33 8 35 (A3) 100 98 70 15 (N3) 87 13 3 113 (A3) 21 28 8 287 (A3) 20 19 8 80 (A3) 100 91 −8 15 (A5) 83 81 3 2 (A5) 3 31 19 2 (A8) 74 75 8 15 (A8) 100 81 24 63 (A3) 14 13 330 (A3) 14 6 173 (A3) −12 50 253 (A3) 100 34 42 (A3) 100 74 305 (A3) 19 −6 12 (A3) 100 63 93 (A3) 10 6 246 (A3) −7 13 36 (A3) 99 44 79 (A3) 90 98 88 130 (A3) 86 93 60 95 (A3) 100 96 98 21 (A3) 44 92 50 75 (A3) 53 78 15 15 (H3) 63 46 0 239 (A3) 51 11 5 244 (A3) −2 45 115 (A3) 2 5 15 Key to Tables Y1 and Y2 *METHOD 1 (otherwise METHOD 2) 6 h = 1 hour 1 d = day ERYSGT = Erysiphe graminis tritici PHYTIN = Phytophthora infestans lycopersici PLASVI = Plasmopara viticola PUCCRT = Puccinia recondita LEPTNO = Septoria nodorum UNCINE = Uncinula necator PYRIOR = Pyricularia oryzae RHIZO = Rhizoctonia solani VENTIN = Venturia inaequalis BOTRCI = Botrytis cinerea

[1038] 4 E = X + Y - XY 100 19 Application rate/(mg of compound/litre) Observed Expected Compound A Compound B PRCO (/%) PRCO (/%) 100 0 21 — 0 0.1 48 — 100 0.1 81 59.2

[1039] 20 TABLE ZI SEPTORIA NODORUM - Compound 15 (A3) and azoxystrobin. Test 1 Test 2 (Disease on (Disease on COMPOUND APPLICATION untreated: 52%) untreated: 64%) RATE/(mg/l) % disease control % disease control Compound 15 (A3) azoxystrobin Observed Expected Observed Expected 100 0 27 / 21 / 50 0 16 / 21 / 0 0.25 37 / 71 / 0 0.1 41 / 48 / 100 0.25 89 54.01 92 77.09 100 0.1 84 56.93 81 58.92 50 0.25 82 47.08 80 77.09 50 0.1 73 50.44 75 58.92 Conclusion: The mixtures show synergy.

[1040] 21 TABLE Z2 PLASMOPARA VITICOLA - Compound 15 (A3) and azoxystrobin. (Disease COMPOUND on untreated: 95%) APPLICATION RATE/(mg/l) % disease control Compound 15 (A3) azoxystrobin Observed Expected 0.2 0 45 / 0 0.2 61 / 0.2 0.2 100 79 Conclusion: The mixture shows synergy.

[1041] 22 TABLE Z3 PLASMOPARA VITICOLA - Compound 15 (A3) and fluazinam. (Disease COMPOUND on untreated: 95%) APPLICATION RATE/(mg/l) % disease control Compound 15 (A3) fluazinam Observed Expected 0.2 0 45 / 0 1 4 / 0.2 1 96 47 Conclusion: The mixture shows synergy.

[1042] 23 TABLE Z4 PLASMOPARA VITICOLA - Compound 15 (A3) and fenamidone. (Disease COMPOUND on untreated: 95%) APPLICATION RATE/(mg/l) % disease control Compound 15 (A3) fenamidone Observed Expected 0.2 0 45 / 0 0.2 65 / 0.2 0.2 100 83 Conclusion: The mixture shows synergy.

[1043] 24 TABLE Z5 RHIZOCTONIA SOLANI - Compound 15 (A3) and azoxystrobin. Test 1 Test 1 (Disease on untreated (Disease on untreated 100%; assessed 100%; assessed COMPOUND APPLICATION 5 days after treatment 5 days after treatment RATE/(mg/l) % disease control % disease control Compound 15 (A3) azoxystrobin Observed Expected Observed Expected 300 0 2.5 / 6.1 / 0 0.1 38.25 / 19.7 / 0 0.3 71.25 / / / 300 0.1 66.25 40.3 51 26.4 300 0.3 87.5 71.97 / / Conclusion: The mixtures show synergy.

[1044] 25 TABLE Z6 RHIZOCTONIA SOLANI - Compound 15 (A3) and fluazinam. Test 1 Test 1 (Disease on untreated (Disease on untreated 100%; assessed 100%; assessed COMPOUND APPLICATION 5 days after treatment 5 days after treatment RATE/(mg/l) % disease control % disease control Compound 15 (A3) fluazinam Observed Expected Observed Expected 300 0 2.5 / 6.1 / 0 10 48.75 / 18.4 / 0 3 15 / / / 300 10 86 50.0 79.6 23.37 300 3 40 17.125 / / Conclusion: The mixtures show synergy.

[1045] 5

Claims

1. A compound of formula (I):

6

wherein X is O or S; n is 0 or 1; Y is O, S or NR7; R1 is hydrogen, halogen, C1-6 alkyl, C1-6 haloalkyl, C1-6 alkoxy, C1-6 haloalkoxy, C1-6 alkylthio, C1-6 haloalkylthio, C3-6 cycloalkyl, C1-6 alkoxy(C1-6)alkyl or SF5; R2 is hydrogen, halogen, C1-6 alkyl, C1-6 alkoxy, C1-6 haloalkoxy, C1-6 alkylthio, C1-6 haloalkylthio, C1-6 alkylsulfinyl, C1-6 haloalkylsulfinyl, C1-6 alkylsulfonyl, C1-6 haloalkylsulfonyl, C1-6 haloalkyl, cyano, nitro, CHO, CH═NOR5, C1-6 alkylcarbonyl, C1-6 alkoxycarbonyl or SF5; or together R1 and R2 form a five or six membered saturated or-unsaturated carbocyclic ring, optionally substituted by one or two C1-6 alkyl groups; R3 is hydrogen, C1-6 alkyl, CH2(C1-4 haloalkyl), C1-6 cyanoalkyl, C3-6 alkenyl, C3-6 alkynyl, C1-6-alkoxy(C1-6)alkyl, C1-6 alkylthio(C1-6)alkyl, C1-6 alkoxy(C1-6)alkoxy(C1-6)alkyl, C1-6 alkylcarbonyl, C1-6 alkoxycarbonyl, formyl, C1-6 alkylcarbonyl(C1-6)alkyl, C1-6 alkoxycarbonyl(C1-6)alkyl, C1-6 alkylaninQcarbonyl, di(C1-6)alkylaminocarbonyl, optionally substituted phenoxycarbonyl, optionally substituted phenyl(C1-6)alkyl or S(O)qR6; R4 is hydrogen, halogen, cyano, C1-8 alkyl, C1-6 haloalkyl, C1-6 cyanoalkyl, C2-6 alkenyl, C2-6 alkynyl, C3-7 cycloalkyl, C3-7 halocycloalkyl, C3-7 cyanocycloalkyl, C1-3 alkyl(C3-7)cycloalkyl, C1-3 alkyl(C3-7)halocycloalkyl, C3-6 cycloalkyl(C1-6)alkyl, C1-6 cycloalkenyl, C5-6 cycloalkenyl(C1-6)alkyl, C2-6 haloalkenyl, C1-6 cyanoalkenyl, C1-6 alkoxy(C1-6)alkyl, formyl, C1-6 carboxyalkyl, C1-6 alkylcarbonyl(C1-6)alkyl, C1-6 alkoxycarbonyl(C1-6)alkyl, C1-6 alkylthio(C1-6)alkyl, C1-6 alkylsulfinyl(C1-6)alkyl, C1-6 alkylsulfonyl(C1-6)alkyl, aminocarbonyl(C1-6)alkyl, C1-6 alkylaminocarbonyl(C1-6)alkyl, di(C1-6)alkylaminocarbonyl(C1-6)alkyl, C1-6 alkoxycarbonyl, C1-6 alkylcarbonyl, aminocarbonyl, C1-6 alkylaminocarbonyl, di(C1-6)alkylaminocarbonyl, optionally substituted phenyl, optionally substituted phenyl(C1-4)alkyl, optionally substituted phenyl(C2-4)alkenyl, optionally substituted heteroaryl, optionally substituted heteroaryl(C1-4)alkyl, optionally substituted heterocyclyl, optionally substituted heterocyclyl(C1-4)alkyl, a group OR8, a group SH, a group S(O)pR9, a group NR10R11 or a group C(R12)═NOR13; R5 is hydrogen, C1-6 alkyl, optionally substituted phenyl or optionally substituted phenyl(C1-4)alkyl; R6 is C1-6 alkyl, C1-6 haloalkyl or optionally substituted phenyl; R7 is hydrogen, cyano, C1-8 alkyl, C1-6 haloalkyl, C1-6 cyanoalkyl, C2-6 alkenyl, C2-6 alkynyl, C3-7 cycloalkyl, C2-6 haloalkenyl, C3-6 cycloalkyl(C1-6)alkyl, C1-6 alkoxy(C1)alkyl, C1-6 alkoxycarbonyl, C1-6 alkylcarbonyl, C1-6 -alkylaminocarbonyl, di(C1-6)alkylaminocarbonyl, optionally substituted phenyl or optionally substituted heteroaryl; R8 is hydrogen, C1-6 alkyl, C1-6 haloalkyl, C3-6 alkenyl, C1-4 cyanoalkyl, C1-6 alkoxycarbonyl(C1-6)alkyl, optionally substituted phenyl, optionally substituted phenyl(C1-4)alkyl, optionally substituted heteroaryl, N═C(CH3)2; R9 is C1-6 alkyl, C1-6 haloalkyl, C3-6 alkenyl, cyano, C1-4cyanoalkyl, C1-6 alkoxycarbonyl(C1-6)alkyl, optionally substituted phenyl, optionally substituted phenyl(C1-4)alkyl or optionally substituted heteroaryl; R10 and R11 are, independently, hydrogen, C1-8 alkyl, C3-7 cycloalkyl, C3-6 alkenyl, C3-6 alkynyl, C2-6 haloalkyl, C1-6 alkoxy(C1-6)alkyl, C1-6 alkoxycarbonyl, optionally substituted phenoxycarbonyl, formyl, C1-6 alkylcarbonyl, C1-6 alkylSO2, optionally substituted phenylSO2 or optionally substituted phenyl(C1-4)alkyl; R12 C1-3 alkyl; R13 is C1-6 alkyl; R13 is C1-6 alkyl, optionally substituted phenyl(C1-2)alkyl; and p and q are, independently, 0, 1 or 2.

2. A compound of formula (Ia) or a compound of formula (Ib):

7

wherein R1, R2, R3, R4, X, Y and n are as claimed in claim 1.

3. A compound of formula (1) as claimed in claim 1 or 2 wherein n is zero.

4. A compound of formula (Ia) or a compound of formula (Ib) as claimed in claim 3 wherein R1 is C1-2 allyl.

5. A compound of formula (Ia) or a compound of formula (Ib) as claimed in claim 3 or 4 wherein R2 is hydrogen, cyano or halogen.

6. A compound of formula (Ia) or a compound of formula (Ib) as claimed in claim 3, 4 or 5 wherein R3 is hydrogen, C1-6 alkyl or C1-6 alkoxy(C1-6)alkyl.

7. A compound of formula (Ia) or a compound of formula (Ib) as claimed in claim 3, 4, 5 or 6 wherein R4 is hydrogen, SH, C1-6 alkyl, C3-6 cycloalkyl, C2-6 alkenyl, C2-5 alkynyl, C1-4 haloalkyl, C1-4 cyanoalkyl, C2-6 haloalkenyl, optionally substituted heterocyclyl(C1-4)alkyl, C2-6 cyanoalkenyl, phenyl (optionally substituted with fluoro, chloro, bromo, nitro, cyano, C1-6 alkyl, C1-2 alkoxy, C1-4 haloalkyl, C1-4 haloalkoxy, methanesulfonyl, methylenedioxy or di(C1-4 alkyl)amino), phenyl(C1-3)alkyl (phenyl optionally substituted with halogen, nitro, cyano, C1-6 alkyl, C1-2 alkoxy, C1-4 haloalkyl, C1-4 haloalkoxy, methanesulfonyl, or methylenedioxy), formyl, optionally substituted heterocyclyl, optionally substituted heteroaryl, optionally substituted heteroaryl(C1-4)alkyl, C1-2 alkylcarbonyl, C1-4 alkoxycarbonyl, C1-5 alkoxycarbonyl(C1-4)alkyl, a group NR10R11, a group OR8, C1-4 alkoxymethyl, chlorine, a group SR9, or a group C(R)12═NOR13; R8 is hydrogen, C1-5 alkyl, C1-4 haloalkyl, C2-4 alkenyl, phenyl (optionally substituted with fluoro, chloro, bromo, nitro, cyano, C1-6 alkyl, C1-2 alkoxy, C1-4 haloalkyl, C1-4 haloalkoxy, methanesulfonyl, or methylenedioxy), phenyl(CH2) (phenyl optionally substituted with fluoro, chloro, bromo, nitro, cyano, C1-6 alkyl, C1-2 alkoxy, C1-4 haloalkyl, C1-4 haloalkoxy, methanesulfonyl, or methylenedioxy), N═C(CH3)2; R9 is C1-5 alkyl, phenyl (optionally substituted with fluoro, chloro, bromo, nitro, cyano, C1-6 alkyl, C1-2alkoxy, C1-4 haloalkyl, C1-4 haloalkoxy, methanesulfonyl, methylenedioxy or di(C1-4 alkyl)amino), C1-2 haloalkyl, cyano, cyanomethyl or C1-2 alkoxycarbonylmethyl; R10 and R11 are, independently, hydrogen, C1-4 alkyl, C5-6 cycloalkyl, formyl, C1-3 alkylcarbonyl, phenoxycarbonyl, C1-2 alkylSO2 or phenylSO2; R12 is C1-2 alkyl; and R13 is C1-2 alkyl or benzyl.

8. A compound of formula (I) as claimed in any one of the preceding claims wherein log10Ko/w (calculated usingthe CLOGP3 program, available from BioByte Corp.) of the compound is in the range zero to 8.

9. A compound of formula (I) as claimed in any one of the preceding claims wherein in the side chain portion of formula (XIX):

8

no atom having an atomic weight greater than 10 Daltons is more than four bond lengths away from at least one atom present in the longest bond path or, when there is a set of longest bond paths, no atom having an atomic weight greater than 10 Daltons is more than four bond lengths away from at least one atom present in each of the longest bond paths.

10. Processes for making compounds of formula (I) as defined in claim 1 comprising:

(i) acylation of a compound of formula (II) by a compound of formula (III):

9

wherein R1, R2, R3, R4, X, Y and n are as described in claim 1; or

(ii) acylation of a compound of formula (VIII):

10

wherein R1, R2, R3, X, Y and n are as described in claim 1, followed by cyclisation of the resultant product.

11. A fungicidal, insecticidal, acaricidal, molluscicidal or nematicidal composition comprising a fungicidally, insecticidally, acaricidally, molluscicidally or nematicidally effective amount of a compound of formula (I) as claimed in claim 1 and a carrier or diluent therefor.

12. A method of combating and controlling fungi comprising applying to a plant, to a seed of a plant, to the locus of the plant or seed or to the soil a fungicidally effective amount of a compound of formula (I) as claimed in claim 1, or a composition containing a compound of formula (I) as claimed in claim 11.

13. A method of combating and controlling fungi comprising applying to a plant, to a seed of a plant, to the locus of the plant or seed or to the soil a fungicidally effective amount of a first active ingredient, which is a compound of formula (I) as claimed in claim 1; and a second active ingredient which is azoxystrobin, picoxystrobin, kresoxim-methyl, trifloxystrobin, metominostrobin or SSF129; wherein the weight ratio of the first active ingredient to the second active ingredient is in the range from 5000:1 to 1:10, the relative amounts of the first and second active ingredients being such as to produce a synergistic effect.

14. A method of combating and controlling fungal infections of plants caused by Plasmopara spp. or Rhizoctonia spp., the method comprising applying to a plant, to a seed of a plant, to the locus of the plant or seed or to the soil a fungicidally effective amount of a first active ingredient, which is a compound of formula (1) as claimed in claim 1; and a second active ingredient which is fluazinam; wherein the weight ratio of the first active ingredient to the second active ingredient is in the range from 500:1 to 1:10, the relative amounts of the first and second active ingredients being such as to produce a synergistic effect.

15. A method of combating and controlling fungal infections of plants caused by Plasmopara spp., the method comprising applying to a plant, to a seed of a plant, to the locus of the plant or seed or to the soil a fungicidally effective amount of a first active ingredient, which is a compound of formula (1) as claimed in claim 1; and a second active ingredient which is fenamidone or famoxadone; wherein the weight ratio of the first active ingredient to the second active ingredient is in the range from 10:1 to 1:10, the relative amounts of the first and second active ingredients being such as to produce a synergistic effect.

16. A method of combating and controlling insects, acarines, nematodes or molluscs which comprises applying to a pest, to a locus of a pest, or to a plant susceptible to attack by a pest an insecticidaily, acaricidally, nematicidally or molluscicidally effective amount of a compound of formula (I) as claimed in claim 1, or a composition containing a compound of formula (I) as claimed in claim 11.

17. A method as claimed in claim 16 wherein the insect pests are insect pests of plants.