Cyclobutanetetracarboxylate compound and preparation method thereof

Abstract

The invention provides a cyclobutanetetracarboxylate compound of general formula (I) and a preparation method thereof: in which R and R1 are as defined in the specification.

Description

BACKGROUND OF THE INVENTION

1. Field of the Invention

The present invention relates to a cyclobutanetetracarboxylate compound and a preparation method thereof.

2. Description of the Prior Art

Cyclobutanetetracarboxylic dianhydrides are important monomer materials for the preparation of an alignment film useful for flat panel displays. Japanese Laid-open Hei 2003-192685 discloses a process for producing cyclobutanetetracarboxylic dianhydride comprising irradiating maleic anhydride to synthesize the cyclobutanetetracarboxylic dianhydride. This process, however, suffers from the shortcomings of a low yield in the production of the butane structure.

To overcome the above shortcomings, the inventors of the subject application developed a new synthesis route comprising synthesizing a cyclobutanetetracarboxylate, hydrolyzing the cyclobutanetetracarboxylate, and dehydrating the hydrolyzed product to obtain the corresponding cyclobutanetetracarboxylic dianhydride. The new route according to the present invention achieves an improved yield of the desired compounds.

SUMMARY OF THE INVENTION

One of the objects of the invention is to provide a cyclobutanetetracarboxylate compound.

Another object of the invention is to provide a process for preparing the cyclobutanetetracarboxylate compound.

DETAILED DESCRIPTION OF THE INVENTION

The invention provides a cyclobutanetetracarboxylate compound of the general formula (I):
in which:

• R can be the same or R is different from each other and independently represents hydrogen or a halogen or a monovalent organic radical; and R₁ is a C₁-C₄ alkyl.

There are no special requirements for the species of the monovalent organic radical suitable for the present invention. Preferably, the monovalent organic radical is a C1-C4 alkyl, which can be straight-chained, branched, or cyclic; and more preferably, is methyl, ethyl, propyl, isopropyl, butyl, or isobutyl.

The invention further provides a process for preparing the cyclobutanetetracarboxylate compound of formula (I). The inventive process comprises the steps of:

(a) conducting an esterification reaction of a diacid compound of general formula (II)
(in which R is as defined hereinbefore) with an alcohol of general formula (III)
R₁—OH  Formula (III)
in the presence of an acidic solvent to obtain a precursor compound of general formula (IV)

(b) conducting a cyclization reaction by irradiating the precursor compound of general formula (IV) with an energy ray to obtain the cyclobutanetetracarboxylate compound of general formula (I).

The acidic solvent used in the inventive process can also be used as a catalyst to enhance the reaction rate. Suitable acidic solvent can be a mono-protonic inorganic acid, a multi-protonic inorganic acid, or an organic acid, which preferably is hydrochloric acid or sulfuric acid.

The esterification reaction in step (a) of the inventive process is obvious to persons skilled in the art. The suitable species of the alcohol will vary with the desired product to be obtained and may include, for example, methanol, ethanol, propanol, or isopropanol. The diacid compound used in the present invention is a fumaric acid. The esterification reaction is conducted at a temperature ranging from 60 to 110° C. for 2 to 20 hours.

The energy ray used in step (b) of the inventive process refers to a light source with a wavelength of from 200 to 600 nm, preferably an ultraviolet light. In general, the irradiation time will vary with the wavelength of the energy ray and is normally in the range of from about 30 minutes to 30 hours. In addition, if desired, the reaction of step (b) can be conducted in the presence of a solvent that is beneficial to the progress of the reaction. Examples of such solvent include ethyl acetate, acetone, water, or a mixture thereof.

The compound of formula (I) according to the present invention can be catalytically hydrolyzed in the presence of an acid or a base in a conventional manner known to persons skilled in the art to form the corresponding cyclobutanetetracarboxylic acid, which can be further dehydrated to form the corresponding cyclobutanetetracarboxylic dianhydride.

The present invention will be further described in the following example. However, the example will not make any limitations to the scope of the invention. Any modifications or alterations on the invention that can be easily accomplished by persons skilled in the art are encompassed in the disclosure of the specification and the accompanying claims.

EXAMPLE

Synthesis of a cyclobutanetetracarboxylic dianhydride

In a 5-liter flask, methanol (3000 ml, 75 mol) and then fumaric acid (1160 g, 10 mol) and concentrated sulfuric acid (10 ml, 0.2 mol) were added. The reaction was conducted at a controlled temperature of 75° C. for 10 hours and then cooled to room temperature. The resultant solid was collected by vacuum filtration and washed with methanol to obtain dimethyl fumarate (1224 g, 8.5 mol).

The dimethyl fumarate (1224 g, 8.5 mol) and water (4000 ml) were added to a 6-liter flask and irradiated by 365 nm ultraviolet lights for 7 hours. The resultant solid in the flask was vacuum filtered to obtain tetramethyl cyclobutane-1,2,3,4-tetracarboxylate (1224 g, 4.25 mol).

The resultant tetramethyl cyclobutane-1,2,3,4-tetracarboxylate (1224 g, 4.25 mol) and aqueous hydrochloric acid (3000 ml) were added to a 5-liter flask; reacted at a controlled temperature of 85° C. for 24 hours; cooled to room temperature; concentrated; and dried to obtain cyclobutane-1,2,3,4-tetracarboxylic acid (870 g, 3.75 mol).

The cyclobutane-1,2,3,4-tetracarboxylic acid (501 g, 2.16 mol) and acetic anhydride (3000 ml) were added to a 5-liter flask and reacted at a controlled temperature of 150° C. for 24 hours. The reaction was cooled to room temperature; concentrated; and dried to obtain 1,2,3,4-cyclobutanetetracarboxylic dianhydride (573 g, 2.93 mol).

Claims

1. A cyclobutanetetracarboxylate compound of general formula (I): in which:

R can be the same or R is different from each other and independently represents hydrogen or a halogen or a monovalent organic radical;

and R1 is a C1-C4 alkyl.

2. The cyclobutanetetracarboxylate compound of claim 1, wherein said monovalent organic radical is a straight-chained, branched, or cyclic C1-C4 alkyl.

3. The cyclobutanetetracarboxylate compound of claim 1, wherein said monovalent organic radical is methyl, ethyl, propyl, isopropyl, butyl, or isobutyl.

4. A process for the preparation of the cyclobutanetetracarboxylate compound as defined in claim 1, comprising:

(a) conducting an esterification reaction of a diacid compound of general formula (II)

(in which R is as defined hereinbefore) with an alcohol of general formula (III)

R1—OH  Formula (III)

in the presence of an acidic solvent to obtain a precursor compound of general formula (IV)

(b) conducting a cyclization reaction by irradiating the precursor compound of general formula (IV) with an energy ray to obtain the cyclobutanetetracarboxylate compound of general formula (I).

5. The process of claim 4 wherein the alcohol of general formula (III) is methanol, ethanol, propanol, or isopropanol.

6. The process of claim 4 wherein the reaction of step (a) is conducted at a temperature from 60 to 110° C.

7. The process of claim 4 wherein the reaction of step (a) is conducted for 2 to 20 hours.

8. The process of claim 4 wherein the energy ray used in step (b) is a light source having a wavelength of from 200 to 600 nm.

9. The process of claim 4 wherein the energy ray used in step (b) is an ultraviolet light.

10. The process of claim 4 wherein the reaction of step (b) is conducted for 30 minutes to 30 hours.

11. The process of claim 4 wherein the reaction of step (b) is conducted in the presence of a solvent.

12. The process of claim 11 wherein the solvent is ethyl acetate, acetone, water, or methanol, or a mixture thereof.