CROSS-REFERENCE TO RELATED APPLICATIONS This application is a continuation of Application No. PCT/CA2009/000694 filed May 28, 2009, now pending, which claims priority benefit of U.S. Provisional Application No. 61/056,827, filed May 28, 2008, the entire contents both of which are incorporated herein by reference.
FIELD OF THE INVENTION This invention relates to the field of diagnostics and in particular to systems and methods for classifying prostate cancer into distinct clinical disease states.
BACKGROUND Prostate cancer is the most common malignancy affecting U.S. men, with approximately 240,000 new cases diagnosed each year. The incidence of prostate cancer is increasing, in part due to increased surveillance efforts from the application of routine molecular testing such as prostate-specific antigen (PSA). For most men, prostate cancer is a slow-growing, organ-confined or localized malignancy that poses little risk of death. The most common treatments for prostate cancer in the U.S. are surgical procedures such as radical prostatectomy, where the entire prostate is removed from the patient. This procedure on its own is highly curative for most but not all men.
The vast majority of deaths from prostate cancer occur in patients with metastasis, believed to be present already at the time of diagnosis in the form of clinically undetectable micro-metastases. In these patients, it is clear that prostatectomy alone is not curative and additional therapies such as anti-androgen or radiation therapy are required to control the spread of disease and extend the life of the patient.
Most prostatectomy patients however face uncertainty with respect to their prognosis after surgery: whether or not the initial surgery will be curative several years from the initial treatment because the current methods for assessment of the clinical risk such as the various pathological (e.g., tumor stage), histological (e.g., Gleason's), clinical (e.g., Kattan nomogram) and molecular biomarkers (e.g., PSA) are not reliable predictors of prognosis, specifically disease progression. Routine PSA testing has certainly increased surveillance and early-detection rates of prostate cancer and this has resulted in an increased number of patients being treated but not significantly decreased the mortality rate.
Despite the controversies surrounding PSA testing as a screening tool, most physicians confidently rely on PSA testing to assess pre-treatment prognosis and to monitor disease progression after initial therapy. Successive increases in PSA levels above a defined threshold value or variations thereof (i.e. ‘Rising-PSA’), also known as biochemical recurrence has been shown to be correlated to disease progression after first-line therapy (e.g., prostatectomy, radiation and brachytherapy). However, less than a ⅓ of patients with ‘rising-PSA’ will eventually be diagnosed with systemic or metastatic disease and several studies have shown that after long-term follow up, the majority will never show any symptoms of disease progression aside from increases in PSA measurement. The limitations of using the PSA biomarker and the absence of additional biomarkers for predicting disease recurrence have led to the development of statistical models combining several clinical and pathological features including PSA results. Several of these ‘nomograms’ have been shown to improve the predictive power for disease recurrence in individual patients over any single independent variable. These models (see Citation #14) are used routinely in the clinic and are currently the best available tools for prediction of outcomes, although they do not provide high levels of accuracy for groups of patients with highly similar histological/pathological features or those at ‘intermediate’ risk of disease recurrence after prostatectomy.
The use of quantitative molecular analyses has the potential to increase the sensitivity, specificity and/or overall accuracy of disease prognosis and provide a more objective basis for determination of risk stratification as compared to conventional clinical-pathological risk models (see Citation #13). The PSA test demonstrates the deficiencies of relying on the measurement of any single biomarker in clinically heterogeneous and complex prostate cancer genomes. Therefore, genomic-based approaches measuring combinations of biomarkers or a signature of disease recurrence are currently being investigated as better surrogates for predicting disease outcome (see Citations # 1-13). For prostate cancer patients these efforts are aimed at reducing the number of unnecessary surgeries for patients without progressive disease and avoid inadvertent under-treatment for higher risk patients. To date, genomic profiling efforts to identify DNA-based (e.g., copy-number alterations, methylation changes), RNA-based (e.g., gene or non-coding RNA expression) or protein-based (e.g., protein expression or modification) signatures, useful for disease prognosis have not however resulted in widespread clinical use.
There are several key reasons explaining why prior genomic profiling methods for prostate cancer have not yet been incorporated in the clinic. These include the small sample sizes typical of individual studies, coupled with variations due to differences in study protocols, clinical heterogeneity of patients and lack of external validation data, which combined have made identifying a robust and reproducible disease signature elusive. Specifically for gene or RNA expression based prognostic models; the mitigating technological limitations include the quality and quantity of RNA that can be isolated from routine clinical samples. Routine clinical samples of prostate cancer include needle-biopsies and surgical resections that have been fixed in formalin and embedded in paraffin wax (FFPE). FFPE-derived RNA is typically degraded and fragmented to between 100-300 bp in size and without poly-A tails making it of little use for traditional 3′-biased gene expression profiling, which requires larger microgram quantities of RNA with intact poly-A tails to prime cDNA synthesis.
Furthermore, as <2% of the genome encodes for protein, traditional gene expression profiling in fact captures only a small fraction of the transcriptome and variation in expression as most RNA molecules that are transcribed are not translated into protein but serve other functional roles and non-coding RNAs are the most abundant transcript species in the genome.
This background information is provided for the purpose of making known information believed by the applicant to be of possible relevance to the present invention. No admission is necessarily intended, nor should be construed, that any of the preceding information constitutes prior art against the present invention.
SUMMARY OF THE INVENTION An object of the present invention is to provide systems and methods for expression-based discrimination of distinct clinical disease states in prostate cancer. In accordance with one aspect of the present invention, there is provided a system for expression-based assessment of risk of prostate cancer recurrence after prostatectomy, said system comprising one or more polynucleotides, each of said polynucleotides capable of specifically hybridizing to a RNA transcript of a gene selected from the group of genes set forth in Table 3 and/or 6.
In accordance with another aspect of the present invention, there is provided a nucleic acid array for expression-based assessment of prostate cancer recurrence risk, said array comprising at least ten probes immobilized on a solid support, each of said probes being between about 15 and about 500 nucleotides in length, each of said probes being derived from a sequence corresponding to, or complementary to, a transcript of a gene selected from the group of genes set forth in Table 3 and/or 6, or a portion of said transcript.
In accordance with another aspect of the present invention, there is provided a method for expression-based assessment of prostate cancer recurrence, said method comprising: (a) determining the expression level of one or more transcripts of one or more genes in a test sample obtained from said subject to provide an expression pattern profile, said one or more genes selected from the group of genes set forth in Table 3 and/or 6, and (c) comparing said expression pattern profile with a reference expression pattern profile.
In accordance with another aspect of the present invention, there is provided a kit for characterizing the expression of one or more nucleic acid sequences depicted in SEQ ID NOs: 1-2114 comprising one or more nucleic acids selected from (a) a nucleic acid depicted in any of SEQ ID NOs: 1-2114; (b) an RNA form of any of the nucleic acids depicted in SEQ ID NOs: 1-2114; (c) a peptide nucleic acid form of any of the nucleic acids depicted in SEQ ID NOs: 1-2114; (d) a nucleic acid comprising at least 20 consecutive bases of any of (a-c); (e) a nucleic acid comprising at least 25 consecutive bases having at least 90% sequence identity to any of (a-c); or (f) a complement to any of (a-e); and optionally instructions for correlating the expression level of said one or more nucleic acid sequences with the disease state of prostate cancer tissue.
In accordance with another aspect of the present invention, there is provided an array of probe nucleic acids certified for use in expression-based assessment of prostate cancer recurrence risk, wherein said array comprises at least two different probe nucleic acids that specifically hybridize to corresponding different target nucleic acids depicted in one of SEQ ID NOs: 1-2114, an RNA form thereof, or a complement to either thereof.
In accordance with another aspect of the present invention, there is provided a device for classifying a biological sample from a prostate cancer as recurrent or non-recurrent, the device comprising means for measuring the expression level of one or more transcripts of one or more genes selected from the group of genes set forth in Table 3 and/or 6; means for correlating the expression level with a classification of prostate cancer status; and means for outputting the prostate cancer status.
In accordance with another aspect of the present invention, there is provided a computer-readable medium comprising one or more digitally-encoded expression pattern profiles representative of the level of expression of one or more transcripts of one or more genes selected from the group of genes set forth in Table 3 and/or 6, each of said one or more expression pattern profiles being associated with a value wherein each of said values is correlated with the presence of recurrent or non-recurrent prostate cancer.
BRIEF DESCRIPTION OF THE DRAWINGS These and other features of the invention will become more apparent in the following detailed description in which reference is made to the appended drawings.
FIG. 1. A) Principle components analysis (PCA) of 2,114 RNAs identified to be differentially expressed between tumors from patients with differing clinical outcome (see Table 2 for comparisons evaluated), PCA plot of 22 prostate cancer tumors shows tight clustering of samples by clinical outcome of patients (circles, NED; diamonds, PSA; squares, SYS). B) Two-way hierarchical clustering dendrogram and expression matrix of 526 target sequences (Table 4) RNAs filtered using linear regression (p<0.01) to identify RNAs that followed either SYS>PSA>NED or NED>PSA>SYS trend in differential expression. C) Two-way hierarchical clustering dendrogram and expression matrix of 148 target sequences (Table 5), a subset of the most differentially expressed transcripts between patients with clinically significant ‘recurrent’ (i.e., ‘SYS’) and ‘non-recurrent’ (i.e., ‘PSA’ and ‘NED’) disease as filtered using a t-test (p<0.001). For B) and C), sample and RNAs were optimally ordered using Pearson's correlation distance metric with complete-linkage cluster distances and the expression of each RNA in each sample was normalized in the heatmap by the number of standard deviations above (blacker) and below (whiter) the median expression value (grey) across all samples.
FIG. 2. Histograms showing distribution patient's tumor expression levels of a ‘metagene’ generated from a linear combination of the 526 RNAs for each clinical group. The histograms bin samples with similar metagene expression values and significantly separate three modes of patient metagene scores (ANOVA, p<0.000001) corresponding to the three clinical status groups evaluated.
FIG. 3. Scatter plots summarizing the mean (±standard deviation) of metagene expression values for tumor samples from patients in the three clinical status groups (NED; PSA; SYS). Metagenes were generated from a linear combinations of 6 (▴), 18 (♦) or 20 (▪) RNAs and demonstrate highly significant differential expression between clinical groups (ANOVA, p<0.000001).
FIG. 4. Box plots showing interquartile range and distribution of ‘POP’ scores for each clinical group using an 18-target sequence metagene (Table 7) to derive patient outcome predictor scores scaled and normalized on a data range of 0-100 points. T-tests were used to evaluate the statistical significance of differences in POP scores between NED and PSA (*) as well as between PSA and SYS (**) clinical groups (p<7×10−7 and p<1×10−6, respectively).
FIG. 5. Box plots showing interquartile range and distribution of ‘POP’ scores for each clinical group using a 10-target sequence metagene (Table 9) to derive patient outcome predictor scores scaled and normalized on a data range of 0-100 points. T-tests were used to evaluate the statistical significance of differences in POP scores between ‘recurrent’ (i.e., ‘SYS’) and non-recurrent (i.e., ‘PSA’ and ‘NED’) patient groups (**, p<4×10−10).
FIG. 6. Box plots showing interquartile range and distribution of ‘POP’ scores for each clinical group using a 41-target sequence metagene (Table 10) to derive patient outcome predictor scores scaled and normalized on a data range of 0-100 points. T-tests were used to evaluate the statistical significance of differences in POP scores between ‘recurrent’ (i.e., ‘SYS’) and non-recurrent (i.e., ‘PSA’ and ‘NED’) patient groups (**, p<2×10−11).
FIG. 7. Box plots showing interquartile range and distribution of ‘POP’ scores for each clinical group using a 148-target sequence metagene to derive patient outcome predictor scores scaled and normalized on a data range of 0-100 points. T-tests were used to evaluate the statistical significance of differences in POP scores between ‘recurrent’ (i.e., ‘SYS’) and non-recurrent (i.e., ‘PSA’ and ‘NED’) patient groups (**, p<9×10−12).
DETAILED DESCRIPTION OF THE INVENTION The present invention provides a system and method for assessing prostate cancer recurrence risk by distinguishing clinically distinct disease states in men with prostate cancer at the time of initial diagnosis or surgery. The system and methods are based on the identification of gene transcripts following a retrospective analysis of tumor samples that are differentially expressed in prostate cancer in a manner dependent on prostate cancer aggressiveness as indicated by long-term post-prostatectomy clinical outcome. These gene transcripts can be considered as a library which can be used as a resource for the identification of sets of specific target sequences (“prostate cancer prognostic sets”), which may represent the entire library of gene transcripts or a subset of the library and the detection of which is indicative of prostate cancer recurrence risk. The invention further provides for probes capable of detecting these target sequences and primers that are capable of amplifying the target sequences.
In accordance with one embodiment of the invention, the system and method for assessing prostate cancer recurrence risk are prognostic for a post surgery clinical outcome selected from no evidence of disease (‘NED’), biochemical relapse (two successive increases in prostate-specific antigen levels; (‘PSA’) and systemic prostate cancer systemic metastases (‘SYS’).
In accordance with one embodiment of the invention, the target sequences comprised by the prostate cancer prognostic set are sequences based on or derived from the gene transcripts from the library, or a subset thereof. Such sequences are occasionally referred to herein as “probe selection regions” or “PSRs.” In another embodiment of the invention, the target sequences comprised by the prostate classification set are sequences based on the gene transcripts from the library, or a subset thereof, and include both coding and non-coding sequences.
In one embodiment, the systems and methods provide for the molecular analysis of the expression levels of one or more of the target sequences as set forth in SEQ ID NOs: 1-2114 (Table 4). Increased relative expression of one or more target sequences in a ‘NED’ Group corresponding to the sequences as set forth in SEQ ID NOs: 1-913 is indicative of or predictive of a non-recurrent form of prostate cancer and can be correlated with an increased likelihood of a long-term NED prognosis or low risk of prostate cancer recurrence. Increased relative expression of one or more target sequences in a ‘SYS’ Group corresponding to the sequences as set forth in SEQ ID NOs: 914-2114 is indicative of or predictive of an aggressive form of prostate cancer and can be correlated with an increased likelihood of a long-term SYS prognosis or high risk of prostate cancer recurrence. Optionally, intermediate relative levels of one or more target sequences in a ‘PSA’ Group corresponding to target sequences set forth in Table 7 is indicative of or predictive of biochemical recurrence. Subsets and combinations of these target sequences or probes complementary thereto may be used as described herein.
Before the present invention is described in further detail, it is to be understood that this invention is not limited to the particular methodology, compositions, articles or machines described, as such methods, compositions, articles or machines can, of course, vary. It is also to be understood that the terminology used herein is for the purpose of describing particular embodiments only, and is not intended to limit the scope of the present invention.
DEFINITIONS Unless defined otherwise or the context clearly dictates otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. In describing the present invention, the following terms will be employed, and are intended to be defined as indicated below.
The term “polynucleotide” as used herein refers to a polymer of greater than one nucleotide in length of ribonucleic acid (RNA), deoxyribonucleic acid (DNA), hybrid RNA/DNA, modified RNA or DNA, or RNA or DNA mimetics, including peptide nucleic acids (PNAs). The polynucleotides may be single- or double-stranded. The term includes polynucleotides composed of naturally-occurring nucleobases, sugars and covalent internucleoside (backbone) linkages as well as polynucleotides having non-naturally-occurring portions which function similarly. Such modified or substituted polynucleotides are well-known in the art and for the purposes of the present invention, are referred to as “analogues.”
“Complementary” or “substantially complementary” refers to the ability to hybridize or base pair between nucleotides or nucleic acids, such as, for instance, between a sensor peptide nucleic acid or polynucleotide and a target polynucleotide. Complementary nucleotides are, generally, A and T (or A and U), or C and G. Two single-stranded polynucleotides or PNAs are said to be substantially complementary when the bases of one strand, optimally aligned and compared and with appropriate insertions or deletions, pair with at least about 80% of the bases of the other strand, usually at least about 90% to 95%, and more preferably from about 98 to 100%.
Alternatively, substantial complementarity exists when a polynucleotide will hybridize under selective hybridization conditions to its complement. Typically, selective hybridization will occur when there is at least about 65% complementarity over a stretch of at least 14 to 25 bases, for example at least about 75%, or at least about 90% complementarity. See, M. Kanehisa Nucleic Acids Res. 12:203 (1984).
“Preferential binding” or “preferential hybridization” refers to the increased propensity of one polynucleotide to bind to its complement in a sample as compared to a noncomplementary polymer in the sample.
Hybridization conditions will typically include salt concentrations of less than about 1M, more usually less than about 500 mM, for example less than about 200 mM. In the case of hybridization between a peptide nucleic acid and a polynucleotide, the hybridization can be done in solutions containing little or no salt. Hybridization temperatures can be as low as 5° C., but are typically greater than 22° C., and more typically greater than about 30° C., for example in excess of about 37° C. Longer fragments may require higher hybridization temperatures for specific hybridization as is known in the art. Other factors may affect the stringency of hybridization, including base composition and length of the complementary strands, presence of organic solvents and extent of base mismatching, and the combination of parameters used is more important than the absolute measure of any one alone. Other hybridization conditions which may be controlled include buffer type and concentration, solution pH, presence and concentration of blocking reagents to decrease background binding such as repeat sequences or blocking protein solutions, detergent type(s) and concentrations, molecules such as polymers which increase the relative concentration of the polynucleotides, metal ion(s) and their concentration(s), chelator(s) and their concentrations, and other conditions known in the art.
“Multiplexing” herein refers to an assay or other analytical method in which multiple analytes can be assayed simultaneously.
A “target sequence” as used herein (also occasionally referred to as a “PSR” or “probe selection region”) refers to a region of the genome against which one or more probes can be designed. As used herein, a probe is any polynucleotide capable of selectively hybridizing to a target sequence or its complement, or to an RNA version of either. A probe may comprise ribonucleotides, deoxyribonucleotides, peptide nucleic acids, and combinations thereof. A probe may optionally comprise one or more labels. In some embodiments, a probe may be used to amplify one or both strands of a target sequence or an RNA form thereof, acting as a sole primer in an amplification reaction or as a member of a set of primers.
“Having” is an open ended phrase like “comprising” and “including,” and includes circumstances where additional elements are included and circumstances where they are not.
“Optional” or “optionally” means that the subsequently described event or circumstance may or may not occur, and that the description includes instances where the event or circumstance occurs and instances in which it does not.
As used herein ‘NED’ describes a clinically distinct disease state in which patients show no evidence of disease (‘NED’) at least 5 years after surgery, ‘PSA’ describes a clinically distinct disease state in which patients show biochemical relapse only (two successive increases in prostate-specific antigen levels but no other symptoms of disease with at least 5 years follow up after surgery; ‘PSA’) and ‘SYS’ describes a clinically distinct disease state in which patients develop biochemical relapse and present with systemic prostate cancer disease or metastases (‘SYS’) within five years after the initial treatment with radical prostatectomy.
As used herein, the term “about” refers to approximately a +/−10% variation from a given value. It is to be understood that such a variation is always included in any given value provided herein, whether or not it is specifically referred to.
Use of the singular forms “a,” “an,” and “the” include plural references unless the context clearly dictates otherwise. Thus, for example, reference to “a polynucleotide” includes a plurality of polynucleotides, reference to “a target” includes a plurality of such targets, reference to “a normalization method” includes a plurality of such methods, and the like. Additionally, use of specific plural references, such as “two,” “three,” etc., read on larger numbers of the same subject, unless the context clearly dictates otherwise.
Terms such as “connected,” “attached,” “linked” and “conjugated” are used interchangeably herein and encompass direct as well as indirect connection, attachment, linkage or conjugation unless the context clearly dictates otherwise.
Where a range of values is recited, it is to be understood that each intervening integer value, and each fraction thereof, between the recited upper and lower limits of that range is also specifically disclosed, along with each subrange between such values. The upper and lower limits of any range can independently be included in or excluded from the range, and each range where either, neither or both limits are included is also encompassed within the invention. Where a value being discussed has inherent limits, for example where a component can be present at a concentration of from 0 to 100%, or where the pH of an aqueous solution can range from 1 to 14, those inherent limits are specifically disclosed. Where a value is explicitly recited, it is to be understood that values which are about the same quantity or amount as the recited value are also within the scope of the invention, as are ranges based thereon. Where a combination is disclosed, each subcombination of the elements of that combination is also specifically disclosed and is within the scope of the invention. Conversely, where different elements or groups of elements are disclosed, combinations thereof are also disclosed. Where any element of an invention is disclosed as having a plurality of alternatives, examples of that invention in which each alternative is excluded singly or in any combination with the other alternatives are also hereby disclosed; more than one element of an invention can have such exclusions, and all combinations of elements having such exclusions are hereby disclosed.
Prostate Cancer Prognostic System The system of the present invention is based on the identification of a library of gene and RNA transcripts that are differentially expressed in prostate cancer in a manner dependent on prostate cancer aggressiveness as indicated by the post-prostatectomy clinical outcome of the patient. For example, relative over expression of one or more of the gene transcripts in a prostate cancer sample compared to a reference sample or expression profile or signature there from may be prognostic of a clinically distinct disease outcome post-prostatectomy selected from no evidence of disease (‘NED’), biochemical relapse (‘PSA’) and prostate cancer disease systemic recurrence or metastases (‘SYS’). The reference sample can be, for example, from prostate cancer sample(s) of one or more references subject(s) with a known post-prostatectomy clinical outcomes. The reference expression profile or signature may optionally be normalized to one or more appropriate reference gene transcripts. Alternatively or in addition to, expression of one or more of the gene transcripts in a prostate cancer sample may be compared to an expression profile or signature from normal prostate tissue.
Expression profiles or signatures from prostate cancer samples may be normalized to one or more house keeping gene transcripts such that normalized over and/or under expression of one or more of the gene transcripts in a sample may be indicative of a clinically distinct disease state or prognosis.
Prostate Prognostic Library The Prostate Prognostic Library in accordance with the present invention comprises one or more gene or RNA transcripts whose relative and/or normalized expression is indicative of prostate cancer recurrence and which may be prognostic for post-prostatectomy clinical outcome of a patient. Exemplary RNA transcripts that showed differential expression in prostate cancer samples from patients with clinically distinct disease outcomes after initial treatment with radical prostatectomy are shown in Table 3. In one embodiment of the invention, the library comprises one or more of the gene transcripts of the genes listed in Table 3.
In one embodiment, the library comprises at least one transcript from at least one gene selected from those listed in Table 3. In one embodiment, the library comprises at least one transcript from each of at least 5 genes selected from those listed in Table 3. In another embodiment, the library comprises at least one transcript from each of at least 10 genes selected from those listed in Table 3. In a further embodiment, the library comprises at least one transcript from each of at least 15 genes selected from those listed in Table 1. In other embodiments, the library comprises at least one transcript from each of at least 20, at least 25, at least 30, at least 35, at least 40, at least 45, at least 50, at least 55, at least 60 and at least 65 genes selected from those listed in Table 3. In a further embodiment, the library comprises at least one transcript from all of the genes listed in Table 3. In a further embodiment, the library comprises at all transcripts from all of the genes listed in Table 3.
In one embodiment, the library comprises at least one transcript from at least one gene selected from the group consisting of [NM—001004722]; [NM—001005522]; [NM—001013671]; [NM—001033517]; [NM—183049]; [NM—212559]; 5′-3′ exoribonuclease 1; A kinase (PRKA) anchor protein (yotiao) 9; AarF domain containing kinase 4; Abhydrolase domain containing 3; Aconitase 1, soluble; Actinin, alpha 1; ADAM metallopeptidase domain 19 (meltrin beta); Adaptor-related protein complex 1, gamma 2 subunit; Adenosine deaminase, RNA-specific, B2 (RED2 homolog rat); Adenylate cyclase 3; ADP-ribosylation factor GTPase activating protein 3; ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited); ADP-ribosylation factor-like 4D; Adrenergic, beta, receptor kinase 2; AF4/FMR2 family, member 3; Amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65); Anaphase promoting complex subunit 1; Ankyrin 3, node of Ranvier (ankyrin G); Ankyrin repeat domain 15; Ankyrin repeat domain 28; Annexin A1; Annexin A2; Anterior pharynx defective 1 homolog B (C. elegans); Anthrax toxin receptor 1; Antizyme inhibitor 1; Arachidonate 12-lipoxygenase, 12R type; Arginine vasopressin receptor 1A; Arginine-glutamic acid dipeptide (RE) repeats; ARP3 actin-related protein 3 homolog (yeast); Arrestin 3, retinal (X-arrestin); Arrestin domain containing 1; Aryl hydrocarbon receptor interacting protein-like 1; Aryl hydrocarbon receptor nuclear translocator; Ataxin 1; ATM/ATR-Substrate Chk2-Interacting Zn2+-finger protein; ATPase, Class I, type 8B, member 1; ATPase, Na+/K+ transporting, alpha 1 polypeptide; ATP-binding cassette, sub-family F (GCN20), member 1; Autism susceptibility candidate 2; Baculoviral IAP repeat-containing 6 (apollon); Basonuclin 2; Brain-specific angiogenesis inhibitor 3; Bromodomain containing 7; Bromodomain containing 8; Bromodomain PHD finger transcription factor; BTB (POZ) domain containing 16; BTB (POZ) domain containing 7; Calcium activated nucleotidase 1; Calcium binding protein P22; Calcium channel, voltage-dependent, beta 4 subunit; Calcium channel, voltage-dependent, L type, alpha 1C subunit; Calcium channel, voltage-dependent, L type, alpha 1D subunit; Calcyclin binding protein; Calmodulin 1 (phosphorylase kinase, delta); Calsyntenin 1; Carbonyl reductase 3; Cardiolipin synthase 1; Carnitine palmitoyltransferase 1A (liver); Casein kinase 1, delta; Casein kinase 1, gamma 1; Casein kinase 1, gamma 3; Caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase); CD109 molecule; CD99 molecule-like 2; CDK5 regulatory subunit associated protein 2; CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 2; Cell adhesion molecule 1; Cell division cycle and apoptosis regulator 1; Centrosomal protein 70 kDa; Chloride channel 3; Chromodomain helicase DNA binding protein 2; Chromodomain helicase DNA binding protein 6; Chromodomain protein, Y-like 2; Chromosome 1 ORF 116; Chromosome 1 ORF 52; Chromosome 10 ORF 118; Chromosome 12 ORF 30; Chromosome 13 ORF 23; Chromosome 16 ORF 45; Chromosome 18 ORF 1; Chromosome 18 ORF 1; Chromosome 18 ORF 1; Chromosome 18 ORF 1; Chromosome 18 ORF 17; Chromosome 2 ORF 3; Chromosome 20 ORF 133; Chromosome 21 ORF 25; Chromosome 21 ORF 34; Chromosome 22 ORF 13; Chromosome 3 ORF 26; Chromosome 5 ORF 3; Chromosome 5 ORF 33; Chromosome 5 ORF 35; Chromosome 5 ORF 39; Chromosome 7 ORF 13; Chromosome 7 ORF 42; Chromosome 9 ORF 3; Chromosome 9 ORF 94; Chromosome Y ORF 15B; Chymase 1, mast cell; Citrate lyase beta like; Class II, major histocompatibility complex, transactivator; C-Maf-inducing protein; Coatomer protein complex, subunit alpha; Cofilin 2 (muscle); Coiled-coil domain containing 50; Coiled-coil domain containing 7; Coiled-coil-helix-coiled-coil-helix domain containing 4; Cold shock domain containing E1, RNA-binding; Collagen, type XII, alpha 1; Complement component 1, r subcomponent-like; Core-binding factor, runt domain, alpha subunit 2; translocated to, 2; CREB binding protein (Rubinstein-Taybi syndrome); CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 2; CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like; CUG triplet repeat, RNA binding protein 2; Cullin 3; Cut-like 2; Cyclin F; Cyclin Y; Cysteine-rich with EGF-like domains 1; Cytochrome P450, family 4, subfamily F, polypeptide 11; Cytoplasmic FMR1 interacting protein 2; DAZ interacting protein 1-like; DCP2 decapping enzyme homolog (S. cerevisiae); DEAD box polypeptide 47; DEAD box polypeptide 5; DEAD box polypeptide 52; DEAD box polypeptide 56; Death inducer-obliterator 1; Dedicator of cytokinesis 2; DEP domain containing 1B; DEP domain containing 2; DEP domain containing 6; Development and differentiation enhancing factor 1; Diacylglycerol lipase, alpha; Diaphanous homolog 2 (Drosophila); Dickkopf homolog 3; Dihydropyrimidine dehydrogenase; Dipeptidyl-peptidase 10; Discs, large homolog 2, chapsyn-110; Dishevelled, dsh homolog 2; DnaJ (Hsp40) homolog, subfamily C, member 6; Dpy-19-like 3; Dual specificity phosphatase 5; Ectodysplasin A receptor; Ectonucleoside triphosphate diphosphohydrolase 7; EGFR-coamplified and overexpressed protein; ELL associated factor 1; Emopamil binding protein (sterol isomerase); Enabled homolog; Ephrin-A5; ER lipid raft associated 1; Erythroblast membrane-associated protein (Scianna blood group); Erythrocyte membrane protein band 4.1 like 4A; Etoposide induced 2.4 mRNA; Eukaryotic translation initiation factor 4E family member 3; FAD1 flavin adenine dinucleotide synthetase homolog; Family with sequence similarity 110, member A; Family with sequence similarity 114, member A1; Family with sequence similarity 135, member A; Family with sequence similarity 40, member A; Family with sequence similarity 80, member B; F-box and leucine-rich repeat protein 11; F-box and leucine-rich repeat protein 7; F-box protein 2; Ferritin, heavy polypeptide 1; Fibronectin type III domain containing 3A; Fibronectin type III domain containing 3B; Fibulin 1; FLJ25476 protein; FLJ41603 protein; Forkhead box J3; Forkhead box J3; Forkhead box K1; Forkhead box P1; Frizzled homolog 3; Frizzled homolog 5; G protein-coupled receptor kinase interactor 2; GABA A receptor, delta; GATA binding protein 2; GDNF family receptor alpha 2; Gelsolin (amyloidosis, Finnish type); Genethonin 1; Glucose phosphate isomerase; Glucose-fructose oxidoreductase domain containing 1; Glucosidase, beta (bile acid) 2; Glutamate dehydrogenase 1; Glutaminase; Glutamyl aminopeptidase (aminopeptidase A); Glutathione reductase
Glycogen synthase kinase 3 beta; Grainyhead-like 2; Gremlin 1, cysteine knot superfamily, homolog; GTPase activating protein (SH3 domain) binding protein 1; Hairy/enhancer-of-split related with YRPW motif 2; Heparan sulfate 6-O-sulfotransferase 3; Hermansky-Pudlak syndrome 5; Heterogeneous nuclear ribonucleoprotein C(C1/C2)
Hippocalcin-like 1; Histocompatibility (minor) 13; Histone cluster 1, H3d; Histone deacetylase 6; Homeobox A1; Homeobox and leucine zipper encoding; Host cell factor C1 (VP16-accessory protein); Hyaluronan binding protein 4; Hyperpolarization activated cyclic nucleotide-gated potassium channel 3; Hypothetical gene supported by AK128346; Hypothetical LOC51149; Hypothetical protein FLJ12949; Hypothetical protein FLJ20035; Hypothetical protein FLJ20309; Hypothetical protein FLJ38482; Hypothetical protein HSPC148; Hypothetical protein LOC130576; Hypothetical protein LOC285908; Hypothetical protein LOC643155; Iduronidase, alpha-L-IKAROS family zinc finger 1 (Ikaros); IlvB (bacterial acetolactate synthase)-like; Inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta; Inositol polyphosphate-4-phosphatase, type II; Integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor); Integrin, alpha 6; Integrin, alpha 9; Integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51); Integrin, beta-like 1 (with EGF-like repeat domains); Inter-alpha (globulin) inhibitor H3; Interleukin enhancer binding factor 3, 90 kDa; Intestine-specific homeobox
Intraflagellar transport 172 homolog; Janus kinase 1; Jumonji domain containing 1B; Jumonji domain containing 2B; Jumonji domain containing 2C; Kalirin, RhoGEF kinase; Kallikrein-related peptidase 2; Karyopherin alpha 3 (importin alpha 4); Keratinocyte associated protein 2; KIAA0152; KIAA0241; KIAA0319-like; KIAA0495; KIAA0562; KIAA0564 protein; KIAA1217; KIAA1244; KIAA1244; La ribonucleoprotein domain family, member 1; Lamin A/C; LATS, large tumor suppressor, homolog 2; Leiomodin 3 (fetal); Leptin receptor overlapping transcript-like 1; Leucine rich repeat containing 16; Leucine-rich repeat kinase 1; Leucine-rich repeat-containing G protein-coupled receptor 4; LIM domain 7; Major histocompatibility complex, class II, DR beta 1; Malignant fibrous histiocytoma amplified sequence 1; Maltase-glucoamylase (alpha-glucosidase); Mannosidase, alpha, class 2A, member 1; Mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase; MBD2-interacting zinc finger; Melanin-concentrating hormone receptor 1; Methionyl-tRNA synthetase; Methyl CpG binding protein 2; Methyl-CpG binding domain protein 5; Microcephaly, primary autosomal recessive 1; Microseminoprotein, beta-; Microtubule-associated protein 1B; Microtubule-associated protein 2; Minichromosome maintenance complex component 3 associated protein; Mitochondrial ribosomal protein S15; Mohawk homeobox; Monooxygenase, DBH-like 1; MORN repeat containing 1; Muscle RAS oncogene homolog; Muscleblind-like; Myelin protein zero-like 1; Myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4; Myocyte enhancer factor 2B; Myosin IF; Myosin, heavy chain 3, skeletal muscle, embryonic; N-acetylgalactosaminidase, alpha-; N-acetylglucosamine-1-phosphate transferase, alpha and beta subunits; Nascent polypeptide-associated complex alpha subunit; NECAP endocytosis associated 2; Necdin homolog; Neural precursor cell expressed, developmentally down-regulated 9; Neuregulin 1; Neuron navigator 1; Nibrin; Nicotinamide N-methyltransferase; NIMA (never in mitosis gene a)-related kinase 6; NLR family, CARD domain containing 5; NOL1/NOP2/Sun domain family, member 3; NOL1/NOP2/Sun domain family, member 3; NOL1/NOP2/Sun domain family, member 6; Nuclear receptor coactivator 2; Nuclear receptor coactivator 6; Nuclear receptor subfamily 2, group F, member 2; Nuclear receptor subfamily 3, group C, member 2; Nuclear receptor subfamily 4, group A, member 2; Nuclear transcription factor, X-box binding-like 1; Nucleolar and coiled-body phosphoprotein 1; Overexpressed in colon carcinoma-1; PAN3 polyA specific ribonuclease subunit homolog; PAP associated domain containing 1; Paraoxonase 2; Paraspeckle component 1; PCTAIRE protein kinase 2; Peptidase D; Pericentrin (kendrin); Peroxisomal biogenesis factor 19; PHD finger protein 8; Phosphatidic acid phosphatase type 2 domain containing 3; Phosphatidylinositol 4-kinase, catalytic, alpha polypeptide; Phosphatidylinositol glycan anchor biosynthesis, class O; Phosphatidylinositol transfer protein, beta; Phosphodiesterase 4D, cAMP-specific; Phosphoglucomutase 5; Phosphoglycerate mutase family member 5; Phosphoinositide-3-kinase, class 2, beta polypeptide; Phospholipase A2, group IVB (cytosolic); Phospholipase C, beta 1 (phosphoinositide-specific); Phospholipase C, gamma 2 (phosphatidylinositol-specific); Phosphorylase kinase, beta; Plasminogen activator, tissue; Platelet-activating factor acetylhydrolase, isoform Ib, alpha subunit 45 kDa; Pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 3; Pleckstrin homology domain containing, family A member 7; Pleckstrin homology domain containing, family G (with RhoGef domain) member 3; Pleckstrin homology domain containing, family H (with MyTH4 domain) member 1; Poly (ADP-ribose) polymerase family, member 16; Poly (ADP-ribose) polymerase family, member 2; Poly(A) polymerase alpha; Poly(A)-specific ribonuclease (deadenylation nuclease); Polymerase (DNA directed) nu; Polymerase (DNA directed), gamma 2, accessory subunit; Polymerase (RNA) II (DNA directed) polypeptide L; Polymerase (RNA) III (DNA directed) polypeptide E; Polymerase I and transcript release factor; Potassium channel tetramerisation domain containing 1; Potassium channel tetramerisation domain containing 2; Potassium channel tetramerisation domain containing 7; Potassium channel, subfamily K, member 1; Presenilin 1; PRKR interacting protein 1; Procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2; ProSAPiP1 protein; Prostaglandin E synthase 3 (cytosolic); Protease, serine, 2 (trypsin 2); Protein kinase, Y-linked; Protein phosphatase 1, regulatory (inhibitor) subunit 9A; Protein phosphatase 3 (formerly 2B), catalytic subunit, alpha isoform; Protein phosphatase 4, regulatory subunit 1-like; Protein tyrosine phosphatase, non-receptor type 18 (brain-derived); Protein tyrosine phosphatase, non-receptor type 3; Protein tyrosine phosphatase, receptor type, D; Protein-O-mannosyltransferase 1; Proteolipid protein 2 (colonic epithelium-enriched); Protocadherin 7; Protocadherin gamma subfamily A, 1; PRP6 pre-mRNA processing factor 6 homolog; Putative homeodomain transcription factor 1; RAB GTPase activating protein 1-like; RAB10; RAB30; Rabaptin, RAB GTPase binding effector protein 1; RAD51-like 1; RALBP1 associated Eps domain containing 2; Rap guanine nucleotide exchange factor (GEF) 1; Rapamycin-insensitive companion of mTOR; Ras and Rab interactor 2; Receptor accessory protein 3; Reelin; Replication factor C (activator 1) 3; Replication protein A3; Rho GTPase activating protein 18; Rho guanine nucleotide exchange factor (GEF) 10-like; Rhophilin, Rho GTPase binding protein 1; Ribonuclease H2, subunit B; Ribonuclease P 14 kDa subunit; Ring finger protein 10; Ring finger protein 144; Ring finger protein 44; RNA binding motif protein 16; Roundabout, axon guidance receptor, homolog 1; Roundabout, axon guidance receptor, homolog 2; RUN domain containing 2A; Scinderin; SEC23 interacting protein; Sec61 alpha 2 subunit; Septin 11; Serine/threonine kinase 32A; Serine/threonine kinase 32C; SGT1, suppressor of G2 allele of SKP1; SH3 and PX domains 2A; Signal peptide peptidase 3; Signal transducer and activator of transcription 1, 91 kDa; Single-stranded DNA binding protein 2; Small nuclear ribonucleoprotein polypeptide N; SNF8, ESCRT-II complex subunit, homolog; Sodium channel, voltage-gated, type III, alpha subunit; Solute carrier family 1 (neutral amino acid transporter), member 5; Solute carrier family 16, member 7 (monocarboxylic acid transporter 2); Solute carrier family 2 (facilitated glucose transporter), member 11; Solute carrier family 2 (facilitated glucose transporter), member 11; Solute carrier family 24 (sodium/potassium/calcium exchanger), member 3; Solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2; Solute carrier family 30 (zinc transporter), member 6; Solute carrier family 39 (zinc transporter), member 10; Solute carrier family 43, member 1; Solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 2; SON DNA binding protein; Sortilin-related VPS10 domain containing receptor 3; Sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2; Spectrin repeat containing, nuclear envelope 1; Sperm associated antigen 9; Splicing factor 3a, subunit 2, 66 kDa; Splicing factor 3b, subunit 1, 155 kDa; Staphylococcal nuclease and tudor domain containing 1; Staufen, RNA binding protein, homolog 1; Suppression of tumorigenicity 7; Suppressor of variegation 4-20 homolog 1; Synapsin III; Syntaxin 3; Syntaxin 5; Tachykinin receptor 1; TAO kinase 3; TBC1 domain family, member 16; TBC1 domain family, member 19; Testis specific, 10; Tetraspanin 6; Tetratricopeptide repeat domain 23; Thioredoxin-like 2; THUMP domain containing 3; TIMELESS interacting protein; TOX high mobility group box family member 4; Trafficking protein, kinesin binding 1; Transcription factor 7-like 1 (T-cell specific, HMG-box); Transcription factor 7-like 2 (T-cell specific, HMG-box); Translocase of inner mitochondrial membrane 13 homolog; Translocated promoter region (to activated MET oncogene); Translocation associated membrane protein 2; Transmembrane 9 superfamily member 2; Transmembrane emp24 protein transport domain containing 8; Transmembrane emp24-like trafficking protein 10; Transmembrane protein 134; Transmembrane protein 18; Transmembrane protein 18; Transmembrane protein 29; Triadin; Tribbles homolog 1; Trinucleotide repeat containing 6C; Tripartite motif-containing 36; Tripartite motif-containing 61; TRNA methyltransferase 11 homolog; TruB pseudouridine (psi) synthase homolog 2; Tubby like protein 4; Tuftelin 1; Tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin); Tumor necrosis factor receptor superfamily, member 25; Tumor necrosis factor, alpha-induced protein 8; Tyrosine kinase 2; Ubiquinol-cytochrome c reductase core protein I; Ubiquitin specific peptidase 47; Ubiquitin specific peptidase 5 (isopeptidase T); Ubiquitin specific peptidase 8; Ubiquitin-like 7 (bone marrow stromal cell-derived); UBX domain containing 6; UDP-glucose ceramide glucosyltransferase-like 2; UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 2 (GalNAc-T2); Unc-93 homolog B1; UTP6, small subunit (SSU) processome component, homolog; Vacuolar protein sorting 8 homolog; V-akt murine thymoma viral oncogene homolog 1; V-ets erythroblastosis virus E26 oncogene homolog; Viral DNA polymerase-transactivated protein 6; WD repeat domain 33; WD repeat domain 90; Wingless-type MMTV integration site family, member 2B; WW and C2 domain containing 1; Yip1 domain family, member 3; YTH domain family, member 3; Zinc finger and BTB domain containing 10; Zinc finger and BTB domain containing 20; Zinc finger and SCAN domain containing 18; Zinc finger homeodomain 4; Zinc finger protein 14 homolog; Zinc finger protein 335; Zinc finger protein 394; Zinc finger protein 407; Zinc finger protein 608; Zinc finger protein 667; Zinc finger protein 692; Zinc finger protein 718; Zinc finger protein 721; Zinc finger, CCHC domain containing 9; Zinc finger, matrin type 1; Zinc finger, MYND domain containing 11; Zinc finger, ZZ-type containing 3; Zinc fingers and homeoboxes 2; and Zwilch, kinetochore associated, homolog.
In one embodiment, the library comprises at least one transcript from at least one gene selected from the group consisting of Replication factor C (activator 1) 3; Tripartite motif-containing 61; Citrate lyase beta like; Ankyrin repeat domain 15; UDP-glucose ceramide glucosyltransferase-like 2; Hypothetical protein FLJ12949; Chromosome 22 open reading frame 13; Phosphatidylinositol glycan anchor biosynthesis, class O; Solute carrier family 43, member 1; Rabaptin, RAB GTPase binding effector protein 1; Zinc finger protein 14 homolog; Hypothetical gene supported by AK128346; Adenylate cyclase 3; Phosphatidylinositol transfer protein, beta; Zinc finger protein 667; Gremlin 1, cysteine knot superfamily, homolog; Ankyrin 3, node of Ranvier (ankyrin G) and Maltase-glucoamylase (alpha-glucosidase).
In one embodiment, the library comprises at least one transcript from at least one gene selected from the group consisting of Replication factor C (activator 1) 3; Ankyrin repeat domain 15; Hypothetical protein FLJ12949; Solute carrier family 43, member 1; Thioredoxin-like 2; Polymerase (RNA) II (DNA directed) polypeptide L; Syntaxin 5; Leucine rich repeat containing 16; Calcium channel, voltage-dependent, beta 4 subunit; [NM—001005522]; G protein-coupled receptor kinase interactor 2; Ankyrin 3, node of Ranvier (ankyrin G); Gremlin 1, cysteine knot superfamily, homolog; Zinc finger protein 667; Hypothetical gene supported by AK128346; Transmembrane 9 superfamily member 2; Potassium channel, subfamily K, member 1; Chromodomain helicase DNA binding protein 2; Microcephaly, primary autosomal recessive 1; Chromosome 21 open reading frame 34 and Dual specificity phosphatase 5.
In one embodiment, the library comprises at least one transcript from at least one gene selected from the group consisting of Replication factor C (activator 1) 3; Tripartite motif-containing 61; Citrate lyase beta like; Ankyrin repeat domain 15; Ankyrin 3, node of Ranvier (ankyrin G) and Maltase-glucoamylase (alpha-glucosidase).
In one embodiment, the library comprises at least one transcript from at least one gene selected from the group consisting of Replication factor C (activator 1) 3; Ankyrin repeat domain 15; Hypothetical protein FLJ12949; Solute carrier family 43, member 1; Thioredoxin-like 2; Polymerase (RNA) II (DNA directed) polypeptide L; Syntaxin 5; Leucine rich repeat containing 16; Calcium channel, voltage-dependent, beta 4 subunit; [NM—001005522]; G protein-coupled receptor kinase interactor 2; Ankyrin 3, node of Ranvier (ankyrin G); Gremlin 1, cysteine knot superfamily, homolog; Zinc finger protein 667; Hypothetical gene supported by AK128346; Transmembrane 9 superfamily member 2; Potassium channel, subfamily K, member 1; Chromodomain helicase DNA binding protein 2; Chromosome 9 open reading frame 94; Chromosome 21 open reading frame 34; and Dual specificity phosphatase 5.
In one embodiment, the library comprises at least one transcript from at least one gene selected from the group consisting of Citrate lyase beta like; Phosphodiesterase 4D, cAMP-specific; Ectodysplasin A receptor; DEP domain containing 6; Basonuclin 2; Chromosome 2 open reading frame 3; FLJ25476 protein; Staphylococcal nuclease and tudor domain containing 1; Hermansky-Pudlak syndrome 5 and Chromosome 12 open reading frame 30.
In one embodiment, the library comprises at least one transcript from at least one gene selected from the group consisting of Replication factor C (activator 1) 3; Tripartite motif-containing 61; Citrate lyase beta like; Adaptor-related protein complex 1, gamma 2 subunit; Kallikrein-related peptidase 2; Phosphodiesterase 4D, cAMP-specific; Cytochrome P450, family 4, subfamily F, polypeptide 11; Ectodysplasin A receptor
Phospholipase C, beta 1; KIAA1244; Paraoxonase 2; Arachidonate 12-lipoxygenase, 12R type; Cut-like 2; Chemokine (C-X-C motif) ligand 12; Rho guanine nucleotide exchange factor (GEF) 5; Olfactory receptor, family 2, subfamily A, member 4; Chromosome 19 open reading frame 42; Hypothetical gene supported by AK128346; Phosphoglucomutase 5; Hyaluronan binding protein 4; NECAP endocytosis associated 2
Myeloid/lymphoid or mixed-lineage leukemia; translocated to, 4; Signal transducer and activator of transcription 1; Chromosome 2 open reading frame 3; FLJ25476 protein; Staphylococcal nuclease and tudor domain containing 1; Transmembrane protein 18; Hermansky-Pudlak syndrome 5; Chromosome 12 open reading frame 30; Splicing factor 3b, subunit 1; Cofilin 2; Heparan sulfate 6-O-sulfotransferase 3; Enabled homolog; Mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase; Solute carrier family 24 (sodium/potassium/calcium exchanger), member 3; Inositol 1,4,5-triphosphate receptor, type 1; CAP-GLY domain containing linker protein; Transglutaminase 4; MOCO sulphurase C-terminal domain containing 2; 4-hydroxyphenylpyruvate dioxygenase-like; and R3H domain containing 1.
The invention also contemplates that alternative libraries may be designed that include transcripts of one or more of the genes in Table 3, together with additional gene transcripts that have previously been shown to be associated with prostate cancer systemic progression. As is known in the art, the publication and sequence databases can be mined using a variety of search strategies to identify appropriate additional candidates for inclusion in the library. For example, currently available scientific and medical publication databases such as Medline, Current Contents, OMIM (online Mendelian inheritance in man), various Biological and Chemical Abstracts, Journal indexes, and the like can be searched using term or key-word searches, or by author, title, or other relevant search parameters. Many such databases are publicly available, and strategies and procedures for identifying publications and their contents, for example, genes, other nucleotide sequences, descriptions, indications, expression pattern, etc, are well known to those skilled in the art. Numerous databases are available through the internet for free or by subscription, see, for example, the National Center Biotechnology Information (NCBI), Infotrieve, Thomson ISI, and Science Magazine (published by the AAAS) websites. Additional or alternative publication or citation databases are also available that provide identical or similar types of information, any of which can be employed in the context of the invention. These databases can be searched for publications describing altered gene expression between recurrent and non-recurrent prostate cancer. Additional potential candidate genes may be identified by searching the above described databases for differentially expressed proteins and by identifying the nucleotide sequence encoding the differentially expressed proteins. A list of genes whose altered expression is between patients with recurrent disease and non-recurrent prostate cancer is presented in Table 6.
Prostate Cancer Prognostic Sets A Prostate Prognostic Set comprises one or more target sequences identified within the gene transcripts in the prostate prognostic library, or a subset of these gene transcripts. The target sequences may be within the coding and/or non-coding regions of the gene transcripts. The set can comprise one or a plurality of target sequences from each gene transcript in the library, or subset thereof. The relative and/or normalized level of these target sequences in a sample is indicative of the level of expression of the particular gene transcript and thus of prostate cancer recurrence risk. For example, the relative and/or normalized expression level of one or more of the target sequences may be indicative of an recurrent form of prostate cancer and therefore prognostic for prostate cancer systemic progression while the relative and/or normalized expression level of one or more other target sequences may be indicative of a non-recurrent form of prostate cancer and therefore prognostic for a NED clinical outcome.
Accordingly, one embodiment of the present invention provides for a library or catalog of candidate target sequences derived from the transcripts (both coding and non-coding regions) of at least one gene suitable for classifying prostate cancer recurrence risk. In a further embodiment, the present invention provides for a library or catalog of candidate target sequences derived from the non-coding regions of transcripts of at least one gene suitable for classifying prostate cancer recurrence risk. In still a further embodiment, the library or catalog of candidate target sequences comprises target sequences derived from the transcripts of one or more of the genes set forth in Table 3 and/or Table 6. The library or catalog in affect provides a resource list of transcripts from which target sequences appropriate for inclusion in a Prostate Cancer Prognostic set can be derived. In one embodiment, an individual Prostate Cancer Prognostic set may comprise target sequences derived from the transcripts of one or more genes exhibiting a positive correlation with recurrent prostate cancer. In one embodiment, an individual Prostate Cancer Prognostic Set may comprise target sequences derived from the transcripts of one or more genes exhibiting a negative correlation with recurrent prostate cancer. In one embodiment, an individual Prostate Cancer Prognostic Set may comprise target sequences derived from the transcripts of two or more genes, wherein at least one gene has a transcript that exhibits a positive correlation with recurrent prostate cancer and at least one gene has a transcript that exhibits negative correlation with recurrent prostate cancer.
In one embodiment, the Prostate Cancer Prognostic Set comprises target sequences derived from the transcripts of at least one gene. In one embodiment, the Prostate Cancer Prognostic Set comprises target sequences derived from the transcripts of at least 5 genes. In another embodiment, the Prostate Cancer Prognostic set comprises target sequences derived from the transcripts of at least 10 genes. In a further embodiment, the Prostate Cancer Prognostic set comprises target sequences derived from the transcripts of at least 15 genes. In other embodiments, the Prostate Cancer Prognostic set comprises target sequences derived from the transcripts of at least 20, at least 25, at least 30, at least 35, at least 40, at least 45, at least 50, at least 55, at least 60 and at least 65 genes.
Following the identification of candidate gene transcripts, appropriate target sequences can be identified by screening for target sequences that have been annotated to be associated with each specific gene locus from a number of annotation sources including GenBank, RefSeq, Ensembl, dbEST, GENSCAN, TWINSCAN, Exoniphy, Vega, microRNAs registry and others (see Affymetrix Exon Array design note).
As part of the target sequence selection process, target sequences can be further evaluated for potential cross-hybridization against other putative transcribed sequences in the design (but not the entire genome) to identify only those target sequences that are predicted to uniquely hybridize to a single target.
Optionally, the set of target sequences that are predicted to uniquely hybridize to a single target can be further filtered using a variety of criteria including, for example, sequence length, for their mean expression levels across a wide selection of human tissues, as being representive of transcripts expressed either as novel alternative (i.e., non-consensus) exons, alternative retained introns, novel exons 5′ or 3′ of the gene's transcriptional start site or representing transcripts expressed in a manner antisense to the gene, amongst others.
In one embodiment, the Prostate Classification Set comprises target sequences derived from 382,253 base pair 3′ of Replication factor C (activator 1) 3, 38 kDa; 58,123 base pair 3′ of Tripartite motif-containing 61; in intron #3 of Citrate lyase beta like; in intron #2 of Ankyrin repeat domain 15; in exon #1 of UDP-glucose ceramide glucosyltransferase-like 2; in exon of #19 of Hypothetical protein FLJ12949; in intron #4 of Chromosome 22 open reading frame 13; in exon #2 of phatidylinositol glycan anchor biosynthesis, class O; in exon #15 of Solute carrier family 43, member 1; in exon #1 of Rabaptin, RAB GTPase binding effector protein 1; in intron #38 of Maltase-glucoamylase (alpha-glucosidase); in intron #23 of Ankyrin 3, node of Ranvier (ankyrin G); 71,333 base pair 3′ of Gremlin 1, cysteine knot superfamily, homolog; 1,561 base pair of 3′ Zinc finger protein 667; in exon #4 of Phosphatidylinositol transfer protein, beta; in intron #18 of Adenylate cyclase 3; and in exon #2 of Hypothetical gene supported by AK128346.
In one embodiment, the Prostate Classification Set comprises target sequences derived from 382,253 base pair 3′ of Replication factor C (activator 1) 3; in intron #2 of Ankyrin repeat domain 15; in exon #19 of Hypothetical protein FLJ12949; in exon #15 of Solute carrier family 43, member 1; 313,721 base pair 3′ of Thioredoxin-like 2; in exon #2 of Polymerase (RNA) II (DNA directed) polypeptide L, 7.6 kDa; in intron #10 of Syntaxin 5; 141,389 base pair 5′ of Leucine rich repeat containing 16; in intron #2 of Calcium channel, voltage-dependent, beta 4 subunit; 5,474 base pair 5′ of [NM—001005522]; in intron #14 of G protein-coupled receptor kinase interactor 2; in intron #23 of Ankyrin 3, node of Ranvier (ankyrin G); 71,333 base pair 3′ of Gremlin 1, cysteine knot superfamily, homolog; 1,561 base pair of 3′ of Zinc finger protein 667; in exon #2 of Hypothetical gene supported by AK128346; in intron #11 of Transmembrane 9 superfamily member 2; in intron #1 of Potassium channel, subfamily K, member 1; in intron #2 of Chromodomain helicase DNA binding protein 2; 22,184 base pair 5′ of Microcephaly, primary autosomal recessive 1; in intron #4 of Chromosome 21 open reading frame 34; and in intron #2 of Dual specificity phosphatase 5.
In one embodiment, the Prostate Classification Set comprises target sequences derived from 382,253 base pair 3′ of Replication factor C (activator 1) 3, 38 kDa; 58,123 base pair 3′ of Tripartite motif-containing 61; in intron #3 of Citrate lyase beta like; in intron #2 of Ankyrin repeat domain 15; in intron #38 of Maltase-glucoamylase (alpha-glucosidase); and in intron #23 of Ankyrin 3, node of Ranvier (ankyrin G).
In one embodiment, the Prostate Classification Set comprises target sequences derived from 382,253 base pair 3′ of Replication factor C (activator 1) 3, 38 kDa; in intron #2 of Ankyrin repeat domain 15; in exon #19 of Hypothetical protein FLJ12949; in exon #15 of Solute carrier family 43, member 1; 313,721 base pair 3′ of Thioredoxin-like 2; in exon #2 of Polymerase (RNA) II (DNA directed) polypeptide L, 7.6 kDa; in intron #10 of Syntaxin 5; 141,389 base pair 5′ of Leucine rich repeat containing 16; in intron #2 of Calcium channel, voltage-dependent, beta 4 subunit; 5,474 base pair 5′ of [NM—001005522]; in intron #14 of G protein-coupled receptor kinase interactor 2; in intron #2 of Ankyrin 3, node of Ranvier (ankyrin G); 71,333 base pair of 3′ Gremlin 1, cysteine knot superfamily; 1,561 base pair 3′ of Zinc finger protein 667; in exon #2 of Hypothetical gene supported by AK128346; in intron #11 of Transmembrane 9 superfamily member 2; in intron #1 of Potassium channel, subfamily K, member 1; in intron #2 of Chromodomain helicase DNA binding protein 2; in exon #8 of Chromosome 9 open reading frame 94; in intron #4 of Chromosome 21 open reading frame 34; and
in intron #2 of Dual specificity phosphatase 5.
In one embodiment, the Prostate Classification Set comprises target sequences derived from in intron #3 of Citrate lyase beta like; 210,560 base pair 5′ of Phosphodiesterase 4D; 189,722 base pair 5′ of Ectodysplasin A receptor; 3,510 base pair 3′ of DEP domain containing 6; in exon #6 of Basonuclin 2; in intron #1 of Chromosome 2 open reading frame 3; in intron #1 of FLJ25476 protein; in intron #10 of Staphylococcal nuclease and tudor domain containing 1; in exon #22 of Hermansky-Pudlak syndrome 5; and in exon #24 of Chromosome 12 open reading frame 30.
In one embodiment, the Prostate Classification Set comprises target sequences derived from 382,253 base pair 3′ of Replication factor C (activator 1) 3, 38 kDa; 58,123 base pair 3′ of Tripartite motif-containing 61; in intron #3 of Citrate lyase beta like; in intron #1 of Adaptor-related protein complex 1, gamma 2 subunit; in intron #2 of Kallikrein-related peptidase 2; 210,560 base pair 5′ of Phosphodiesterase 4D; 3,508 base pair 3′ of Cytochrome P450, family 4, subfamily F, polypeptide 11; 189,722 base pair 5′ of Ectodysplasin A receptor; in intron #2 of Phospholipase C, beta 1; in intron #10 of KIAA1244; in intron #2 of Paraoxonase 2; 11,235 base pair 3′ of Arachidonate 12-lipoxygenase, 12R type; in exon #22 of Cut-like 2; 143,098 base pair 5′ of Chemokine (C-X-C motif) ligand 12; in intron #6 of Rho guanine nucleotide exchange factor (GEF) 5; 15,057 base pair 5′ of Olfactory receptor, family 2, subfamily A, member 4; 6,025 base pair 3′ of Chromosome 19 open reading frame 42; in exon #2 of Hypothetical gene supported by AK128346; in exon #11 of Phosphoglucomutase 5; in exon #9 of Hyaluronan binding protein 4; in exon #8 of NECAP endocytosis associated 2; in intron #20 of Myeloid/lymphoid or mixed-lineage leukemia; 1,558 base pair 3′ of Signal transducer and activator of transcription; in intron #1 of Chromosome 2 open reading frame 3; in intron #1 of FLJ25476 protein; in intron #10 of Staphylococcal nuclease and tudor domain containing 1; 84,468 base pair 3′ of Transmembrane protein 18; in exon #22 of Hermansky-Pudlak syndrome 5; in exon #24 of Chromosome 12 open reading frame 30; 95,745 base pair of 3′ Splicing factor 3b, subunit 1; in exon #4 of Cofilin 2; in intron #1 of Heparan sulfate 6-O-sulfotransferase 3; in intron #1 of Enabled homolog; in intron #2 of Mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase; in intron #8 of Solute carrier family 24, member 3; 32,382 base pair 3′ of Inositol 1,4,5-triphosphate receptor, type 1; in intron #9 of CAP-GLY domain containing linker protein 1; in exon #14 of Transglutaminase 4; in intron #4 of MOCO sulphurase C-terminal domain containing 2; 21,555 base pair 5′ of 4 hydroxyphenylpyruvate dioxygenase-like; and in exon #26 of R3H domain containing 1.
In one embodiment, the potential set of target sequences can be filtered for their expression levels using the multi-tissue expression data made publicly available by Affymetrix at (http://www.affymetrix.com/stipport/technical/sample_data/exon_array_data.affx) such that probes with, for example, elevated expression across numerous tissues (non-specific) or no expression in prostate tissue can be excluded.
Validation of Target Sequences Following in silico selection of target sequences, each target sequence suitable for use in the Prostate Cancer Prognostic Set may be validated to confirm differential relative or normalized expression in recurrent prostate cancer or non-recurrent prostate cancer. Validation methods are known in the art and include hybridization techniques such as microarray analysis or Northern blotting using appropriate controls, and may include one or more additional steps, such as reverse transcription, transcription, PCR, RT-PCR and the like. The validation of the target sequences using these methods is well within the abilities of a worker skilled in the art.
Minimal Expression Signature In one embodiment, individual Prostate Cancer Prognostic Sets provide for at least a determination of a minimal expression signature, capable of distinguishing recurrent from non-recurrent forms of prostate cancer. Means for determining the appropriate number of target sequences necessary to obtain a minimal expression signature are known in the art and include the Nearest Shrunken Centroids (NSC) method.
In this method (see US 20070031873), a standardized centroid is computed for each class. This is the average gene expression for each gene in each class divided by the within-class standard deviation for that gene. Nearest centroid classification takes the gene expression profile of a new sample, and compares it to each of these class centroids. The class whose centroid that it is closest to, in squared distance, is the predicted class for that new sample. Nearest shrunken centroid classification “shrinks” each of the class centroids toward the overall centroid for all classes by an amount called the threshold. This shrinkage consists of moving the centroid towards zero by threshold, setting it equal to zero if it hits zero. For example if threshold was 2.0, a centroid of 3.2 would be shrunk to 1.2, a centroid of −3.4 would be shrunk to −1.4, and a centroid of 1.2 would be shrunk to zero. After shrinking the centroids, the new sample is classified by the usual nearest centroid rule, but using the shrunken class centroids. This shrinkage can make the classifier more accurate by reducing the effect of noisy genes and provides an automatic gene selection. In particular, if a gene is shrunk to zero for all classes, then it is eliminated from the prediction rule. Alternatively, it may be set to zero for all classes except one, and it can be learned that the high or low expression for that gene characterizes that class. The user decides on the value to use for threshold. Typically one examines a number of different choices. To guide in this choice, PAM does K-fold cross-validation for a range of threshold values. The samples are divided up at random into K roughly equally sized parts. For each part in turn, the classifier is built on the other K−1 parts then tested on the remaining part. This is done for a range of threshold values, and the cross-validated misclassification error rate is reported for each threshold value. Typically, the user would choose the threshold value giving the minimum cross-validated misclassification error rate.
Alternatively, minimal expression signatures can be established through the use of optimization algorithms such as the mean variance algorithm widely used in establishing stock portfolios. This method is described in detail in US patent publication number 20030194734. Essentially, the method calls for the establishment of a set of inputs (stocks in financial applications, expression as measured by intensity here) that will optimize the return (e.g., signal that is generated) one receives for using it while minimizing the variability of the return. In other words, the method calls for the establishment of a set of inputs (e.g., expression as measured by intensity) that will optimize the signal while minimizing variability. Many commercial software programs are available to conduct such operations. “Wagner Associates Mean-Variance Optimization Application,” referred to as “Wagner Software” throughout this specification, is preferred. This software uses functions from the “Wagner Associates Mean-Variance Optimization Library” to determine an efficient frontier and optimal portfolios in the Markowitz sense is preferred. Use of this type of software requires that microarray data be transformed so that it can be treated as an input in the way stock return and risk measurements are used when the software is used for its intended financial analysis purposes.
The process of selecting a minimal expression signature can also include the application of heuristic rules. Preferably, such rules are formulated based on biology and an understanding of the technology used to produce clinical results. More preferably, they are applied to output from the optimization method. For example, the mean variance method of portfolio selection can be applied to microarray data for a number of genes differentially expressed in subjects with cancer. Output from the method would be an optimized set of genes that could include some genes that are expressed in peripheral blood as well as in diseased tissue.
Other heuristic rules can be applied that are not necessarily related to the biology in question. For example, one can apply a rule that only a prescribed percentage of the portfolio can be represented by a particular gene or group of genes. Commercially available software such as the Wagner Software readily accommodates these types of heuristics. This can be useful, for example, when factors other than accuracy and precision (e.g., anticipated licensing fees) have an impact on the desirability of including one or more genes.
In one embodiment, the Prostate Cancer Prognostic Set for obtaining a minimal expression signature comprises at least one, two, three, four, five, six, eight, 10, 15, 20, 25 or more of target sequences shown to have a positive correlation with non-recurrent prostate disease, for example those depicted in SEQ ID NOs:1-913 or a subset thereof. In another embodiment, the Prostate Cancer Prognostic Set for obtaining a minimal expression signature comprises at least one, two, three, four, five, six, eight, 10, 15, 20, 25 or more of those target sequences shown to have a positive correlation with recurrent prostate cancer, for example those depicted in of SEQ ID NOs: 914-2114, or a subset thereof. In yet another embodiment, the Prostate Cancer Prognostic Set for obtaining a minimal expression signature comprises at least one, two, three, four, five, six, eight, 10, 15, 20, 25 or more of target sequences shown to have a correlation with non-recurrent or recurrent prostate cancer, for example those depicted in SEQ ID NOs:1-2114 or a subset thereof.
In some embodiments, the Prostate Cancer Prognostic Set comprises target sequences for detecting expression products of SEQ IDs:1-2114. In some embodiments, the Prostate Cancer Prognostic Set comprises probes for detecting expression levels of sequences exhibiting positive and negative correlation with a disease status of interest are employed. For example, a combination target sequences useful in these methods were found to include those encoding RNAs corresponding to SEQ ID NOs: 1-913 (found at increased expression in prostate cancer samples from NED patients) and/or corresponding to SEQ ID NOs: 914-2114 (found at increased expression levels in prostate cancer samples from SYS patients), where intermediate levels of certain target sequences (Table 7) are observed in prostate cancer samples from PSA patients with biochemical recurrence, where the RNA expression levels are indicative of a disease state or outcome. Subgroups of these target sequences, as well as individual target sequences, have been found useful in such methods.
In some embodiments, an RNA signature corresponding to SEQ ID NOs: 1, 4, 6, 9, 14-16, 18-21 915-917, 920, 922, 928, 929, 931, 935 and 936 (the 21-RNA′ signature) and/or SEQ ID NOs: 1-11, 914-920 (the ‘18-RNA’ signature) and/or SEQ ID NOs: 1-4, 914,915) (the ‘6-RNA’ signature) and/or SEQ ID NOs: 1, 4, 6, 9, 14-16, 18-21, 915-917, 920, 922, 928, 929, 931, 935 and 936 (the ‘20-RNA’ signature) and/or SEQ ID NOs 3, 36, 60, 63, 926, 971, 978, 999, 1014 and 1022 (the ‘10-RNA’ signature) and/or SEQ ID NOs 1-3, 32, 33, 36, 46, 60, 63, 66, 69, 88, 100, 241, 265, 334, 437, 920, 925, 934, 945, 947, 954, 971, 978, 999, 1004, 1014, 1022, 1023, 1032, 1080, 1093, 1101, 1164, 1248, 1304, 1311, 1330, 1402 and 1425 (the ‘41-RNA’ signature) are formulated into a linear combination of their respective expression values for each patient generating a patient outcome predictor (‘POP’) score and indicative of the disease status of the patient after prostatectomy.
Exemplary subsets and combinations of interest also include at least five, six, 10, 15, 18, 20, 23, 25, 27, 30, 35, 40, 45, 50, 55, 60, 70, 80, 90, 100, 125, 150, 175, 200, 225, 250, 275, 300, 350, 400, 450, 500, 750, 1000, 1200, 1400, 1600, 1800, 2000, or all 2114 target sequences in Table 4; at least five, six, 10, 15, 18, 20, 23, 25, 27, 30, 35, 40, 45, 50, 55, 60, 70, 80, 90, 100, 125, 150, 175, 200, 225, 250, 275, 300, 350, 400, 450, 500, or all 526 target sequences in Table 7; SEQ ID NOs:1, 4, 915, 6, 916, 9, 917, 920, 922, 14, 15, 16, 928, 929, 18, 19, 931, 20, 21, 935, 936, or combinations thereof; SEQ ID NOs:1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 914, 915, 916, 917, 918, 919, 920, or combinations thereof; SEQ ID NOs: 1, 4, 6, 9, 14-16, 18-21, 915-917, 920, 922, 928, 929, 931, 935, 936 or combinations thereof; SEQ ID NOs 3, 36, 60, 63, 926, 971, 978, 999, 1014, 1022 or combinations thereof; SEQ ID NOs 1-3, 32, 33, 36, 46, 60, 63, 66, 69, 88, 100, 241, 265, 334, 437, 920, 925, 934, 945, 947, 954, 971, 978, 999, 1004, 1014, 1022, 1023, 1032, 1080, 1093, 1101, 1164, 1248, 1304, 1311, 1330, 1402, 1425 or combinations thereof; at least one, two, three, four, five or six of SEQ ID NOs:1, 4, 6, 9, 14, 15, 16, 18, 19, 20, and 21 and at least one, two, three, four, five or six of SEQ ID NOs:915, 916, 917, 920, 922, 928, 929, 931, 935, and 936; and at least one, two, three, four, five or six of SEQ ID NOs:1, 2, 3, 4, 5, 6, 7, 8, 9, 10, and 11 at least one, two, three, four, five or six of at least one, two, three, four, five or six of SEQ ID NOs:914, 915, 916, 917, 918, 919, and 920 and at least one, two, three, four, five or six of SEQ ID NOs: 1, 4, 6, 9, 14-16, 18-21, 915-917, 920, 922, 928, 929, 931, 935, 936; and at least one, two, three, four, five or six of SEQ ID NOs 3, 36, 60, 63, 926, 971, 978, 999, 1014, 1022; and at least one, two, three, four, five or six of SEQ ID NOs 1-3, 32, 33, 36, 46, 60, 63, 66, 69, 88, 100, 241, 265, 334, 437, 920, 925, 934, 945, 947, 954, 971, 978, 999, 1004, 1014, 1022, 1023, 1032, 1080, 1093, 1101, 1164, 1248, 1304, 1311, 1330, 1402, 1425.
Exemplary subsets of interest include those described herein, including in the examples. Exemplary combinations of interest include those utilizing one or more of the sequences listed in Tables 5, 7, 8, 9 or 10. Of particular interest are those combinations utilizing at least one sequence exhibiting positive correlation with the trait of interest, as well as those combinations utilizing at least one sequence exhibiting negative correlation with the trait of interest. Also of interest are those combinations utilizing at least two, at least three, at least four, at least five or at least six of those sequences exhibiting such a positive correlation, in combination with at least two, at least three, at least four, at least five, or at least six of those sequences exhibiting such a negative correlation. Exemplary combinations include those utilizing at least one, two, three, four, five or six of the target sequences depicted in Tables 5 and 6.
In some embodiments, increased relative expression of one or more of SEQ IDs:1-913, decreased relative expression of one or more of SEQ ID NOs:914-2114 or a combination of any thereof is indicative/predictive of the patient exhibiting no evidence of disease for at least seven years or more after surgery. In some embodiments, increased relative expression of SEQ IDs:914-2114, decreased relative expression of one or more of SEQ ID NOs:1-913 or a combination of any thereof is indicative/predictive of the patient exhibiting systemic prostate cancer. Increased or decreased expression of target sequences represented in these sequence listings, or of the target sequences described in the examples, may be utilized in the methods of the invention.
The Prostate Cancer Prognostic Set can optionally include one or more target sequences specifically derived from the transcripts of one or more housekeeping genes and/or one or more internal control target sequences and/or one or more negative control target sequences. In one embodiment, these target sequences can, for example, be used to normalize expression data. Housekeeping genes from which target sequences for inclusion in a Prostate Cancer Prognostic Set can be derived from are known in the art and include those genes in which are expressed at a constant level in normal and prostate cancer tissue.
The target sequences described herein may be used alone or in combination with each other or with other known or later identified disease markers.
Prostate Cancer Prognostic Probes/Primers The system of the present invention provides for combinations of polynucleotide probes that are capable of detecting the target sequences of the Prostate Cancer Prognostic Sets. Individual polynucleotide probes comprise a nucleotide sequence derived from the nucleotide sequence of the target sequences or complementary sequences thereof. The nucleotide sequence of the polynucleotide probe is designed such that it corresponds to, or is complementary to the target sequences. The polynucleotide probe can specifically hybridize under either stringent or lowered stringency hybridization conditions to a region of the target sequences, to the complement thereof, or to a nucleic acid sequence (such as a cDNA) derived therefrom.
The selection of the polynucleotide probe sequences and determination of their uniqueness may be carried out in silico using techniques known in the art, for example, based on a BLASTN search of the polynucleotide sequence in question against gene sequence databases, such as the Human Genome Sequence, UniGene, dbEST or the non-redundant database at NCBI. In one embodiment of the invention, the polynucleotide probe is complementary to a region of a target mRNA derived from a target sequence in the Prostate Cancer Prognostic Set. Computer programs can also be employed to select probe sequences that will not cross hybridize or will not hybridize non-specifically.
One skilled in the art will understand that the nucleotide sequence of the polynucleotide probe need not be identical to its target sequence in order to specifically hybridize thereto. The polynucleotide probes of the present invention, therefore, comprise a nucleotide sequence that is at least about 75% identical to a region of the target gene or mRNA. In another embodiment, the nucleotide sequence of the polynucleotide probe is at least about 90% identical a region of the target gene or mRNA. In a further embodiment, the nucleotide sequence of the polynucleotide probe is at least about 95% identical to a region of the target gene or mRNA. Methods of determining sequence identity are known in the art and can be determined, for example, by using the BLASTN program of the University of Wisconsin Computer Group (GCG) software or provided on the NCBI website. The nucleotide sequence of the polynucleotide probes of the present invention may exhibit variability by differing (e.g. by nucleotide substitution, including transition or transversion) at one, two, three, four or more nucleotides from the sequence of the target gene.
Other criteria known in the art may be employed in the design of the polynucleotide probes of the present invention. For example, the probes can be designed to have <50% G content and/or between about 25% and about 70% G+C content. Strategies to optimize probe hybridization to the target nucleic acid sequence can also be included in the process of probe selection. Hybridization under particular pH, salt, and temperature conditions can be optimized by taking into account melting temperatures and by using empirical rules that correlate with desired hybridization behaviours. Computer models may be used for predicting the intensity and concentration-dependence of probe hybridization.
As is known in the art, in order to represent a unique sequence in the human genome, a probe should be at least 15 nucleotides in length. Accordingly, the polynucleotide probes of the present invention range in length from about 15 nucleotides to the full length of the target sequence or target mRNA. In one embodiment of the invention, the polynucleotide probes are at least about 15 nucleotides in length. In another embodiment, the polynucleotide probes are at least about 20 nucleotides in length. In a further embodiment, the polynucleotide probes are at least about 25 nucleotides in length. In another embodiment, the polynucleotide probes are between about 15 nucleotides and about 500 nucleotides in length. In other embodiments, the polynucleotide probes are between about 15 nucleotides and about 450 nucleotides, about 15 nucleotides and about 400 nucleotides, about 15 nucleotides and about 350 nucleotides, about 15 nucleotides and about 300 nucleotides in length.
The polynucleotide probes of a Prostate Cancer Prognostic Set can comprise RNA, DNA, RNA or DNA mimetics, or combinations thereof, and can be single-stranded or double-stranded. Thus the polynucleotide probes can be composed of naturally-occurring nucleobases, sugars and covalent internucleoside (backbone) linkages as well as polynucleotide probes having non-naturally-occurring portions which function similarly. Such modified or substituted polynucleotide probes may provide desirable properties such as, for example, enhanced affinity for a target gene and increased stability.
The system of the present invention further provides for primers and primer pairs capable of amplifying target sequences defined by the Prostate Cancer Prognostic Set, or fragments or subsequences or complements thereof. The nucleotide sequences of the Prostate Cancer Prognostic set may be provided in computer-readable media for in silico applications and as a basis for the design of appropriate primers for amplification of one or more target sequences of the Prostate Cancer Prognostic Set.
Primers based on the nucleotide sequences of target sequences can be designed for use in amplification of the target sequences. For use in amplification reactions such as PCR, a pair of primers will be used. The exact composition of the primer sequences is not critical to the invention, but for most applications the primers will hybridize to specific sequences of the Prostate Cancer Prognostic Set under stringent conditions, particularly under conditions of high stringency, as known in the art. The pairs of primers are usually chosen so as to generate an amplification product of at least about 50 nucleotides, more usually at least about 100 nucleotides. Algorithms for the selection of primer sequences are generally known, and are available in commercial software packages. These primers may be used in standard quantitative or qualitative PCR-based assays to assess transcript expression levels of RNAs defined by the Prostate Cancer Prognostic Set. Alternatively, these primers may be used in combination with probes, such as molecular beacons in amplifications using real-time PCR.
In one embodiment, the primers or primer pairs, when used in an amplification reaction, specifically amplify at least a portion of a nucleic acid depicted in one of SEQ ID NOs: 1-2114 (or subgroups thereof as set forth herein), an RNA form thereof, or a complement to either thereof.
As is known in the art, a nucleoside is a base-sugar combination and a nucleotide is a nucleoside that further includes a phosphate group covalently linked to the sugar portion of the nucleoside. In forming oligonucleotides, the phosphate groups covalently link adjacent nucleosides to one another to form a linear polymeric compound, with the normal linkage or backbone of RNA and DNA being a 3′ to 5′ phosphodiester linkage. Specific examples of polynucleotide probes or primers useful in this invention include oligonucleotides containing modified backbones or non-natural internucleoside linkages. As defined in this specification, oligonucleotides having modified backbones include both those that retain a phosphorus atom in the backbone and those that lack a phosphorus atom in the backbone. For the purposes of the present invention, and as sometimes referenced in the art, modified oligonucleotides that do not have a phosphorus atom in their internucleoside backbone can also be considered to be oligonucleotides.
Exemplary polynucleotide probes or primers having modified oligonucleotide backbones include, for example, those with one or more modified internucleotide linkages that are phosphorothioates, chiral phosphorothioates, phosphorodithioates, phosphotriesters, aminoalkylphosphotriesters, methyl and other alkyl phosphonates including 3′-alkylene phosphonates and chiral phosphonates, phosphinates, phosphoramidates including 3′ amino phosphoramidate and aminoalkylphosphoramidates, thionophosphoramidates, thionoalkyl-phosphonates, thionoalkylphosphotriesters, and boranophosphates having normal 3′-5′ linkages, 2′-5′ linked analogs of these, and those having inverted polarity wherein the adjacent pairs of nucleoside units are linked 3′-5′ to 5′-3′ or 2′-5′ to 5′-2′. Various salts, mixed salts and free acid forms are also included.
Exemplary modified oligonucleotide backbones that do not include a phosphorus atom are formed by short chain alkyl or cycloalkyl internucleoside linkages, mixed heteroatom and alkyl or cycloalkyl internucleoside linkages, or one or more short chain heteroatomic or heterocyclic internucleoside linkages. Such backbones include morpholino linkages (formed in part from the sugar portion of a nucleoside); siloxane backbones; sulfide, sulfoxide and sulphone backbones; formacetyl and thioformacetyl backbones; methylene formacetyl and thioformacetyl backbones; alkene containing backbones; sulphamate backbones; methyleneimino and methylenehydrazino backbones; sulphonate and sulfonamide backbones; amide backbones; and others having mixed N, O, S and CH2 component parts.
The present invention also contemplates oligonucleotide mimetics in which both the sugar and the internucleoside linkage of the nucleotide units are replaced with novel groups. The base units are maintained for hybridization with an appropriate nucleic acid target compound. An example of such an oligonucleotide mimetic, which has been shown to have excellent hybridization properties, is a peptide nucleic acid (PNA) [Nielsen et al., Science, 254:1497-1500 (1991)]. In PNA compounds, the sugar-backbone of an oligonucleotide is replaced with an amide containing backbone, in particular an aminoethylglycine backbone. The nucleobases are retained and are bound directly or indirectly to aza-nitrogen atoms of the amide portion of the backbone. The present invention also contemplates polynucleotide probes or primers comprising “locked nucleic acids” (LNAs), which are novel conformationally restricted oligonucleotide analogues containing a methylene bridge that connects the 2′-O of ribose with the 4′-C (see, Singh et al., Chem. Commun., 1998, 4:455-456). LNA and LNA analogues display very high duplex thermal stabilities with complementary DNA and RNA, stability towards 3′-exonuclease degradation, and good solubility properties. Synthesis of the LNA analogues of adenine, cytosine, guanine, 5-methylcytosine, thymine and uracil, their oligomerization, and nucleic acid recognition properties have been described (see Koshkin et al., Tetrahedron, 1998, 54:3607-3630). Studies of mis-matched sequences show that LNA obey the Watson-Crick base pairing rules with generally improved selectivity compared to the corresponding unmodified reference strands.
LNAs form duplexes with complementary DNA or RNA or with complementary LNA, with high thermal affinities. The universality of LNA-mediated hybridization has been emphasized by the formation of exceedingly stable LNA:LNA duplexes (Koshkin et al., J. Am. Chem. Soc., 1998, 120:13252-13253). LNA:LNA hybridization was shown to be the most thermally stable nucleic acid type duplex system, and the RNA-mimicking character of LNA was established at the duplex level. Introduction of three LNA monomers (T or A) resulted in significantly increased melting points toward DNA complements.
Synthesis of 2′-amino-LNA (Singh et al., J. Org. Chem., 1998, 63, 10035-10039) and 2′-methylamino-LNA has been described and thermal stability of their duplexes with complementary RNA and DNA strands reported. Preparation of phosphorothioate-LNA and 2′-thio-LNA have also been described (Kumar et al., Bioorg. Med. Chem. Lett., 1998, 8:2219-2222).
Modified polynucleotide probes or primers may also contain one or more substituted sugar moieties. For example, oligonucleotides may comprise sugars with one of the following substituents at the 2′ position: OH; F; O—, S—, or N-alkyl; O—, S—, or N-alkenyl; O—, S— or N-alkynyl; or O-alkyl-O-alkyl, wherein the alkyl, alkenyl and alkynyl may be substituted or unsubstituted C1 to C10 alkyl or C2 to C10 alkenyl and alkynyl. Examples of such groups are: O[(CH2)n O]m CH3, O(CH2)n OCH3, O(CH2)n NH2, O(CH2)n CH3, O(CH2)n ONH2, and O(CH2)n ON[(CH2)n CH3)]2, where n and m are from 1 to about 10. Alternatively, the oligonucleotides may comprise one of the following substituents at the 2′ position: C1 to C10 lower alkyl, substituted lower alkyl, alkaryl, aralkyl, O-alkaryl or O-aralkyl, SH, SCH3, OCN, Cl, Br, CN, CF3, OCF3, SOCH3, SO2 CH3, ONO2, NO2, N3, NH2, heterocycloalkyl, heterocycloalkaryl, aminoalkylamino, polyalkylamino, substituted silyl, an RNA cleaving group, a reporter group, an intercalator, a group for improving the pharmacokinetic properties of an oligonucleotide, or a group for improving the pharmacodynamic properties of an oligonucleotide, and other substituents having similar properties. Specific examples include 2′-methoxyethoxy (2′-O—CH2 CH2 OCH3, also known as 2′-O-(2-methoxyethyl) or 2′-MOE) [Martin et al., Helv. Chim. Acta, 78:486-504 (1995)], 2′-dimethylaminooxyethoxy (O(CH2)2 ON(CH3)2 group, also known as 2′-DMAOE), 2′-methoxy (2′-O—CH3), 2′-aminopropoxy (2′-OCH2 CH2 CH2 NH2) and 2′-fluoro (2′-F).
Similar modifications may also be made at other positions on the polynucleotide probes or primers, particularly the 3′ position of the sugar on the 3′ terminal nucleotide or in 2′-5′ linked oligonucleotides and the 5′ position of 5′ terminal nucleotide. Polynucleotide probes or primers may also have sugar mimetics such as cyclobutyl moieties in place of the pentofuranosyl sugar.
Polynucleotide probes or primers may also include modifications or substitutions to the nucleobase. As used herein, “unmodified” or “natural” nucleobases include the purine bases adenine (A) and guanine (G), and the pyrimidine bases thymine (T), cytosine (C) and uracil (U). Modified nucleobases include other synthetic and natural nucleobases such as 5-methylcytosine (5-me-C), 5-hydroxymethyl cytosine, xanthine, hypoxanthine, 2-aminoadenine, 6-methyl and other alkyl derivatives of adenine and guanine, 2-propyl and other alkyl derivatives of adenine and guanine, 2-thiouracil, 2-thiothymine and 2-thiocytosine, 5-halouracil and cytosine, 5-propynyl uracil and cytosine, 6-azo uracil, cytosine and thymine, 5-uracil (pseudouracil), 4-thiouracil, 8-halo, 8-amino, 8-thiol, 8-thioalkyl, 8-hydroxyl and other 8-substituted adenines and guanines, 5-halo particularly 5-bromo, 5-trifluoromethyl and other 5-substituted uracils and cytosines, 7-methylguanine and 7-methyladenine, 8-azaguanine and 8-azaadenine, 7-deazaguanine and 7-deazaadenine and 3-deazaguanine and 3-deazaadenine. Further nucleobases include those disclosed in U.S. Pat. No. 3,687,808; The Concise Encyclopedia Of Polymer Science And Engineering, (1990) pp 858-859, Kroschwitz, J. I., ed. John Wiley & Sons; Englisch et al., Angewandte Chemie, Int. Ed., 30:613 (1991); and Sanghvi, Y. S., (1993) Antisense Research and Applications, pp 289-302, Crooke, S. T. and Lebleu, B., ed., CRC Press. Certain of these nucleobases are particularly useful for increasing the binding affinity of the polynucleotide probes of the invention. These include 5-substituted pyrimidines, 6-azapyrimidines and N-2, N-6 and O-6 substituted purines, including 2-aminopropyladenine, 5-propynyluracil and 5-propynylcytosine. 5-methylcytosine substitutions have been shown to increase nucleic acid duplex stability by 0.6-1.2° C. [Sanghvi, Y. S., (1993) Antisense Research and Applications, pp 276-278, Crooke, S. T. and Lebleu, B., ed., CRC Press, Boca Raton].
One skilled in the art will recognize that it is not necessary for all positions in a given polynucleotide probe or primer to be uniformly modified. The present invention, therefore, contemplates the incorporation of more than one of the aforementioned modifications into a single polynucleotide probe or even at a single nucleoside within the probe or primer.
One skilled in the art will also appreciate that the nucleotide sequence of the entire length of the polynucleotide probe or primer does not need to be derived from the target sequence. Thus, for example, the polynucleotide probe may comprise nucleotide sequences at the 5′ and/or 3′ termini that are not derived from the target sequences. Nucleotide sequences which are not derived from the nucleotide sequence of the target sequence may provide additional functionality to the polynucleotide probe. For example, they may provide a restriction enzyme recognition sequence or a “tag” that facilitates detection, isolation, purification or immobilisation onto a solid support. Alternatively, the additional nucleotides may provide a self-complementary sequence that allows the primer/probe to adopt a hairpin configuration. Such configurations are necessary for certain probes, for example, molecular beacon and Scorpion probes, which can be used in solution hybridization techniques.
The polynucleotide probes or primers can incorporate moieties useful in detection, isolation, purification, or immobilisation, if desired. Such moieties are well-known in the art (see, for example, Ausubel et al., (1997 & updates) Current Protocols in Molecular Biology, Wiley & Sons, New York) and are chosen such that the ability of the probe to hybridize with its target sequence is not affected.
Examples of suitable moieties are detectable labels, such as radioisotopes, fluorophores, chemiluminophores, enzymes, colloidal particles, and fluorescent microparticles, as well as antigens, antibodies, haptens, avidin/streptavidin, biotin, haptens, enzyme cofactors/substrates, enzymes, and the like.
A label can optionally be attached to or incorporated into a probe or primer polynucleotide to allow detection and/or quantitation of a target polynucleotide representing the target sequence of interest. The target polynucleotide may be the expressed target sequence RNA itself, a cDNA copy thereof, or an amplification product derived therefrom, and may be the positive or negative strand, so long as it can be specifically detected in the assay being used. Similarly, an antibody may be labeled.
In certain multiplex formats, labels used for detecting different targets may be distinguishable. The label can be attached directly (e.g., via covalent linkage) or indirectly, e.g., via a bridging molecule or series of molecules (e.g., a molecule or complex that can bind to an assay component, or via members of a binding pair that can be incorporated into assay components, e.g. biotin-avidin or streptavidin). Many labels are commercially available in activated forms which can readily be used for such conjugation (for example through amine acylation), or labels may be attached through known or determinable conjugation schemes, many of which are known in the art.
Labels useful in the invention described herein include any substance which can be detected when bound to or incorporated into the biomolecule of interest. Any effective detection method can be used, including optical, spectroscopic, electrical, piezoelectrical, magnetic, Raman scattering, surface plasmon resonance, colorimetric, calorimetric, etc. A label is typically selected from a chromophore, a lumiphore, a fluorophore, one member of a quenching system, a chromogen, a hapten, an antigen, a magnetic particle, a material exhibiting nonlinear optics, a semiconductor nanocrystal, a metal nanoparticle, an enzyme, an antibody or binding portion or equivalent thereof, an aptamer, and one member of a binding pair, and combinations thereof. Quenching schemes may be used, wherein a quencher and a fluorophore as members of a quenching pair may be used on a probe, such that a change in optical parameters occurs upon binding to the target introduce or quench the signal from the fluorophore. One example of such a system is a molecular beacon. Suitable quencher/fluorophore systems are known in the art. The label may be bound through a variety of intermediate linkages. For example, a polynucleotide may comprise a biotin-binding species, and an optically detectable label may be conjugated to biotin and then bound to the labeled polynucleotide. Similarly, a polynucleotide sensor may comprise an immunological species such as an antibody or fragment, and a secondary antibody containing an optically detectable label may be added.
Chromophores useful in the methods described herein include any substance which can absorb energy and emit light. For multiplexed assays, a plurality of different signaling chromophores can be used with detectably different emission spectra. The chromophore can be a lumophore or a fluorophore. Typical fluorophores include fluorescent dyes, semiconductor nanocrystals, lanthanide chelates, polynucleotide-specific dyes and green fluorescent protein.
Coding schemes may optionally be used, comprising encoded particles and/or encoded tags associated with different polynucleotides of the invention. A variety of different coding schemes are known in the art, including fluorophores, including SCNCs, deposited metals, and RF tags.
Polynucleotides from the described target sequences may be employed as probes for detecting target sequences expression, for ligation amplification schemes, or may be used as primers for amplification schemes of all or a portion of a target sequences. When amplified, either strand produced by amplification may be provided in purified and/or isolated form.
In one embodiment, polynucleotides of the invention include a nucleic acid depicted in (a) any one of SEQ ID NOs: 1-2114, or a subgroup thereof as set forth herein; (b) an RNA form of any one of the nucleic acids depicted in SEQ ID NOs: 1-2114, or a subgroup thereof as set forth herein; (c) a peptide nucleic acid form of any of the nucleic acids depicted in SEQ ID NOs: 1-2114, or a subgroup thereof as set forth herein; (d) a nucleic acid comprising at least 20 consecutive bases of any of (a-c); (e) a nucleic acid comprising at least 25 bases having at least 90% sequenced identity to any of (a-c); and (f) a complement to any of (a-e).
Complements may take any polymeric form capable of base pairing to the species recited in (a)-(e), including nucleic acid such as RNA or DNA, or may be a neutral polymer such as a peptide nucleic acid. Polynucleotides of the invention can be selected from the subsets of the recited nucleic acids described herein, as well as their complements.
In some embodiments, polynucleotides of the invention comprise at least 20 consecutive bases as depicted in SEQ ID NOs:1-2114, or a complement thereto. The polynucleotides may comprise at least 21, 22, 23, 24, 25, 27, 30, 32, 35 or more consecutive bases as depicted in SEQ ID NOs:1-2114, as applicable.
In some embodiments, the nucleic acid in (a) can be selected from those in Table 3, and from SEQ ID NOs:1, 4, 915, 6, 916, 9, 917, 920, 922, 14, 15, 16, 928, 929, 18, 19, 931, 20, 21, 935, and 936; or from SEQ ID NOs:1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 914, 915, 916, 917, 918, 919, and 920; or from SEQ ID NOs: 1, 4, 6, 9, 14-16, 18-21, 915-917, 920, 922, 928, 929, 931, 935 and 936; or from SEQ ID NOs 3, 36, 60, 63, 926, 971, 978, 999, 1014 and 1022; or from SEQ ID NOs 1-3, 32, 33, 36, 46, 60, 63, 66, 69, 88, 100, 241, 265, 334, 437, 920, 925, 934, 945, 947, 954, 971, 978, 999, 1004, 1014, 1022, 1023, 1032, 1080, 1093, 1101, 1164, 1248, 1304, 1311, 1330, 1402 and 1425.
The polynucleotides may be provided in a variety of formats, including as solids, in solution, or in an array. The polynucleotides may optionally comprise one or more labels, which may be chemically and/or enzymatically incorporated into the polynucleotide.
In one embodiment, solutions comprising polynucleotide and a solvent are also provided. In some embodiments, the solvent may be water or may be predominantly aqueous. In some embodiments, the solution may comprise at least two, three, four, five, six, seven, eight, nine, ten, twelve, fifteen, seventeen, twenty or more different polynucleotides, including primers and primer pairs, of the invention. Additional substances may be included in the solution, alone or in combination, including one or more labels, additional solvents, buffers, biomolecules, polynucleotides, and one or more enzymes useful for performing methods described herein, including polymerases and ligases. The solution may further comprise a primer or primer pair capable of amplifying a polynucleotide of the invention present in the solution.
In some embodiments, one or more polynucleotides provided herein can be provided on a substrate. The substrate can comprise a wide range of material, either biological, nonbiological, organic, inorganic, or a combination of any of these. For example, the substrate may be a polymerized Langmuir Blodgett film, functionalized glass, Si, Ge, GaAs, GaP, SiO2, SiN4, modified silicon, or any one of a wide variety of gels or polymers such as (poly)tetrafluoroethylene, (poly)vinylidenedifluoride, polystyrene, cross-linked polystyrene, polyacrylic, polylactic acid, polyglycolic acid, poly(lactide coglycolide), polyanhydrides, poly(methyl methacrylate), poly(ethylene-co-vinyl acetate), polysiloxanes, polymeric silica, latexes, dextran polymers, epoxies, polycarbonates, or combinations thereof. Conducting polymers and photoconductive materials can be used.
Substrates can be planar crystalline substrates such as silica based substrates (e.g. glass, quartz, or the like), or crystalline substrates used in, e.g., the semiconductor and microprocessor industries, such as silicon, gallium arsenide, indium doped GaN and the like, and includes semiconductor nanocrystals.
The substrate can take the form of an array, a photodiode, an optoelectronic sensor such as an optoelectronic semiconductor chip or optoelectronic thin-film semiconductor, or a biochip. The location(s) of probe(s) on the substrate can be addressable; this can be done in highly dense formats, and the location(s) can be microaddressable or nanoaddressable.
Silica aerogels can also be used as substrates, and can be prepared by methods known in the art. Aerogel substrates may be used as free standing substrates or as a surface coating for another substrate material.
The substrate can take any form and typically is a plate, slide, bead, pellet, disk, particle, microparticle, nanoparticle, strand, precipitate, optionally porous gel, sheets, tube, sphere, container, capillary, pad, slice, film, chip, multiwell plate or dish, optical fiber, etc. The substrate can be any form that is rigid or semi-rigid. The substrate may contain raised or depressed regions on which an assay component is located. The surface of the substrate can be etched using known techniques to provide for desired surface features, for example trenches, v-grooves, mesa structures, or the like.
Surfaces on the substrate can be composed of the same material as the substrate or can be made from a different material, and can be coupled to the substrate by chemical or physical means. Such coupled surfaces may be composed of any of a wide variety of materials, for example, polymers, plastics, resins, polysaccharides, silica or silica-based materials, carbon, metals, inorganic glasses, membranes, or any of the above-listed substrate materials. The surface can be optically transparent and can have surface Si—OH functionalities, such as those found on silica surfaces.
The substrate and/or its optional surface can be chosen to provide appropriate characteristics for the synthetic and/or detection methods used. The substrate and/or surface can be transparent to allow the exposure of the substrate by light applied from multiple directions. The substrate and/or surface may be provided with reflective “mirror” structures to increase the recovery of light.
The substrate and/or its surface is generally resistant to, or is treated to resist, the conditions to which it is to be exposed in use, and can be optionally treated to remove any resistant material after exposure to such conditions.
The substrate or a region thereof may be encoded so that the identity of the sensor located in the substrate or region being queried may be determined Any suitable coding scheme can be used, for example optical codes, RFID tags, magnetic codes, physical codes, fluorescent codes, and combinations of codes.
Preparation of Probes and Primers The polynucleotide probes or primers of the present invention can be prepared by conventional techniques well-known to those skilled in the art. For example, the polynucleotide probes can be prepared using solid-phase synthesis using commercially available equipment. As is well-known in the art, modified oligonucleotides can also be readily prepared by similar methods. The polynucleotide probes can also be synthesized directly on a solid support according to methods standard in the art. This method of synthesizing polynucleotides is particularly useful when the polynucleotide probes are part of a nucleic acid array.
Polynucleotide probes or primers can be fabricated on or attached to the substrate by any suitable method, for example the methods described in U.S. Pat. No. 5,143,854, PCT Publ. No. WO 92/10092, U.S. patent application Ser. No. 07/624,120, filed Dec. 6, 1990 (now abandoned), Fodor et al., Science, 251: 767-777 (1991), and PCT Publ. No. WO 90/15070). Techniques for the synthesis of these arrays using mechanical synthesis strategies are described in, e.g., PCT Publication No. WO 93/09668 and U.S. Pat. No. 5,384,261. Still further techniques include bead based techniques such as those described in PCT Appl. No. PCT/US93/04145 and pin based methods such as those described in U.S. Pat. No. 5,288,514. Additional flow channel or spotting methods applicable to attachment of sensor polynucleotides to a substrate are described in U.S. patent application Ser. No. 07/980,523, filed Nov. 20, 1992, and U.S. Pat. No. 5,384,261.
Alternatively, the polynucleotide probes of the present invention can be prepared by enzymatic digestion of the naturally occurring target gene, or mRNA or cDNA derived therefrom, by methods known in the art.
Prostate Cancer Prognostic Methods The present invention further provides methods for characterizing prostate cancer sample for recurrence risk. The methods use the Prostate Cancer Prognostic Sets, probes and primers described herein to provide expression signatures or profiles from a test sample derived from a subject having or suspected of having prostate cancer. In some embodiments, such methods involve contacting a test sample with Prostate Cancer Prognostic probes (either in solution or immobilized) under conditions that permit hybridization of the probe(s) to any target nucleic acid(s) present in the test sample and then detecting any probe:target duplexes formed as an indication of the presence of the target nucleic acid in the sample. Expression patterns thus determined are then compared to one or more reference profiles or signatures. Optionally, the expression pattern can be normalized. The methods use the Prostate Cancer Prognostic Sets, probes and primers described herein to provide expression signatures or profiles from a test sample derived from a subject to classify the prostate cancer as recurrent or non-recurrent.
In some embodiments, such methods involve the specific amplification of target sequences nucleic acid(s) present in the test sample using methods known in the art to generate an expression profile or signature which is then compared to a reference profile or signature.
In some embodiments, the invention further provides for prognosing patient outcome, predicting likelihood of recurrence after prostatectomy and/or for designating treatment modalities.
In one embodiment, the methods generate expression profiles or signatures detailing the expression of the 2114 target sequences having altered relative expression with different prostate cancer outcomes. In one embodiment, the methods generate expression profiles or signatures detailing the expression of the subsets of these target sequences having 526 or 18 target sequences as described in the examples.
In some embodiments, increased relative expression of one or more of SEQ IDs:1-913, decreased relative expression of one or more of SEQ ID NOs:914-2114 or a combination of any thereof is indicative of a non-recurrent form of prostate cancer and may be predictive a NED clinical outcome after surgery. In some embodiments, increased relative expression of SEQ IDs:914-2114, decreased relative expression of one or more of SEQ ID NOs:1-913 or a combination of any thereof is indicative of a recurrent form of prostate cancer and may be predictive of a SYS clinical outcome after surgery. Increased or decreased expression of target sequences represented in these sequence listings, or of the target sequences described in the examples, may be utilized in the methods of the invention.
In one embodiment, intermediate levels of expression of one or more target sequences depicted in Table 7 indicate a probability of future biochemical recurrence.
In some embodiments, the methods detect combinations of expression levels of sequences exhibiting positive and negative correlation with a disease status. In one embodiment, the methods detect a minimal expression signature.
Any method of detecting and/or quantitating the expression of the encoded target sequences can in principle be used in the invention. Such methods can include Northern blotting, array or microarray hybridization, by enzymatic cleavage of specific structures (e.g., an Invader® assay, Third Wave Technologies, e.g. as described in U.S. Pat. Nos. 5,846,717, 6,090,543; 6,001,567; 5,985,557; and 5,994,069) and amplification methods, e.g. RT-PCR, including in a TaqMan® assay (PE Biosystems, Foster City, Calif., e.g. as described in U.S. Pat. Nos. 5,962,233 and 5,538,848), and may be quantitative or semi-quantitative, and may vary depending on the origin, amount and condition of the available biological sample. Combinations of these methods may also be used. For example, nucleic acids may be amplified, labeled and subjected to microarray analysis. Single-molecule sequencing (e.g., Illumina, Helicos, PacBio, ABI SOLID), in situ hybridization, bead-array technologies (e.g., Luminex xMAP, Illumina BeadChips), branched DNA technology (e.g., Panomics, Genisphere).
The expressed target sequences can be directly detected and/or quantitated, or may be copied and/or amplified to allow detection of amplified copies of the expressed target sequences or its complement. In some embodiments, degraded and/or fragmented RNA can be usefully analyzed for expression levels of target sequences, for example RNA having an RNA integrity number of less than 8.
In some embodiments, quantitative RT-PCR assays are used to measure the expression level of target sequences depicted in SEQ IDs: 1-2114. In other embodiments, a GeneChip or microarray can be used to measure the expression of one or more of the target sequences.
Molecular assays measure the relative expression levels of the target sequences, which can be normalized to the expression levels of one or more control sequences, for example array control sequences and/or one or more housekeeping genes, for example GAPDH. Increased (or decreased) relative expression of the target sequences as described herein, including any of SEQ ID NOs:1-2114, may thus be used alone or in any combination with each other in the methods described herein. In addition, negative control probes may be included.
Diagnostic Samples Diagnostic samples for use with the systems and in the methods of the present invention comprise nucleic acids suitable for providing RNAs expression information. In principle, the biological sample from which the expressed RNA is obtained and analyzed for target sequence expression can be any material suspected of comprising prostate cancer tissue or cells. The diagnostic sample can be a biological sample used directly in a method of the invention. Alternatively, the diagnostic sample can be a sample prepared from a biological sample.
In one embodiments, the sample or portion of the sample comprising or suspected of comprising prostate cancer tissue or cells can be any source of biological material, including cells, tissue or fluid, including bodily fluids. Non-limiting examples of the source of the sample include an aspirate, a needle biopsy, a cytology pellet, a bulk tissue preparation or a section thereof obtained for example by surgery or autopsy, lymph fluid, blood, plasma, serum, tumors, and organs.
The samples may be archival samples, having a known and documented medical outcome, or may be samples from current patients whose ultimate medical outcome is not yet known.
In some embodiments, the sample may be dissected prior to molecular analysis. The sample may be prepared via macrodissection of a bulk tumor specimen or portion thereof, or may be treated via microdissection, for example via Laser Capture Microdissection (LCM).
The sample may initially be provided in a variety of states, as fresh tissue, fresh frozen tissue, fine needle aspirates, and may be fixed or unfixed. Frequently, medical laboratories routinely prepare medical samples in a fixed state, which facilitates tissue storage. A variety of fixatives can be used to fix tissue to stabilize the morphology of cells, and may be used alone or in combination with other agents. Exemplary fixatives include crosslinking agents, alcohols, acetone, Bouin's solution, Zenker solution, Hely solution, osmic acid solution and Carnoy solution.
Crosslinking fixatives can comprise any agent suitable for forming two or more covalent bonds, for example an aldehyde. Sources of aldehydes typically used for fixation include formaldehyde, paraformaldehyde, glutaraldehyde or formalin. Preferably, the crosslinking agent comprises formaldehyde, which may be included in its native form or in the form of paraformaldehyde or formalin. One of skill in the art would appreciate that for samples in which crosslinking fixatives have been used special preparatory steps may be necessary including for example heating steps and proteinase-k digestion; see methods
One or more alcohols may be used to fix tissue, alone or in combination with other fixatives. Exemplary alcohols used for fixation include methanol, ethanol and isopropanol.
Formalin fixation is frequently used in medical laboratories. Formalin comprises both an alcohol, typically methanol, and formaldehyde, both of which can act to fix a biological sample.
Whether fixed or unfixed, the biological sample may optionally be embedded in an embedding medium. Exemplary embedding media used in histology including paraffin, Tissue-Tek® V.I.P.™, Paramat, Paramat Extra, Paraplast, Paraplast X-tra, Paraplast Plus, Peel Away Paraffin Embedding Wax, Polyester Wax, Carbowax Polyethylene Glycol, Polyfin™, Tissue Freezing Medium TFM™, Cryo-Gel™, and OCT Compound (Electron Microscopy Sciences, Hatfield, Pa.). Prior to molecular analysis, the embedding material may be removed via any suitable techniques, as known in the art. For example, where the sample is embedded in wax, the embedding material may be removed by extraction with organic solvent(s), for example xylenes. Kits are commercially available for removing embedding media from tissues. Samples or sections thereof may be subjected to further processing steps as needed, for example serial hydration or dehydration steps.
In some embodiments, the sample is a fixed, wax-embedded biological sample. Frequently, samples from medical laboratories are provided as fixed, wax-embedded samples, most commonly as formalin-fixed, paraffin embedded (FFPE) tissues.
Whatever the source of the biological sample, the target polynucleotide that is ultimately assayed can be prepared synthetically (in the case of control sequences), but typically is purified from the biological source and subjected to one or more preparative steps. The RNA may be purified to remove or diminish one or more undesired components from the biological sample or to concentrate it. Conversely, where the RNA is too concentrated for the particular assay, it may be diluted.
RNA Extraction RNA can be extracted and purified from biological samples using any suitable technique. A number of techniques are known in the art, and several are commercially available (e.g., FormaPure™ nucleic acid extraction kit, Agencourt Biosciences, Beverly Mass., High Pure FFPE RNA Micro Kit™, Roche Applied Science, Indianapolis, Ind.). RNA can be extracted from frozen tissue sections using TRIzol (Invitrogen, Carlsbad, Calif.) and purified using RNeasy Protect kit (Qiagen, Valencia, Calif.). RNA can be further purified using DNAse I treatment (Ambion, Austin, Tex.) to eliminate any contaminating DNA. RNA concentrations can be made using a Nanodrop ND-1000 spectrophotometer (Nanodrop Technologies, Rockland, Del.). RNA integrity can be evaluated by running electropherograms, and RNA integrity number (RIN, a correlative measure that indicates intactness of mRNA) can be determined using the RNA 6000 PicoAssay for the Bioanalyzer 2100 (Agilent Technologies, Santa Clara, Calif.).
Reverse Transcription for QRT-PCR Analysis Reverse transcription can be performed using the Omniscript kit (Qiagen, Valencia, Calif.), Superscript III kit (Invitrogen, Carlsbad, Calif.), for RT-PCR. Target-specific priming can be performed in order to increase the sensitivity of detection of target sequences and generate target-specific cDNA.
TaqMan® Gene Expression Analysis
TaqMan® RT-PCR can be performed using Applied Biosystems Prism (ABI) 7900 HT instruments in a 5 μl volume with target sequence-specific cDNA equivalent to 1 ng total RNA. Primers and probes concentrations for TaqMan analysis are added to amplify fluorescent amplicons using PCR cycling conditions such as 95° C. for 10 minutes for one cycle, 95° C. for 20 seconds, and 60° C. for 45 seconds for 40 cycles. A reference sample can be assayed to ensure reagent and process stability. Negative controls (i.e., no template) should be assayed to monitor any exogenous nucleic acid contamination.
Amplification and Hybridization Following sample collection and nucleic acid extraction, the nucleic acid portion of the sample comprising RNA that is or can be used to prepare the target polynucleotide(s) of interest can be subjected to one or more preparative reactions. These preparative reactions can include in vitro transcription (IVT), labeling, fragmentation, amplification and other reactions. mRNA can first be treated with reverse transcriptase and a primer to create cDNA prior to detection, quantitation and/or amplification; this can be done in vitro with purified mRNA or in situ, e.g., in cells or tissues affixed to a slide.
By “amplification” is meant any process of producing at least one copy of a nucleic acid, in this case an expressed RNA, and in many cases produces multiple copies. An amplification product can be RNA or DNA, and may include a complementary strand to the expressed target sequence. DNA amplification products can be produced initially through reverse translation and then optionally from further amplification reactions. The amplification product may include all or a portion of a target sequence, and may optionally be labeled. A variety of amplification methods are suitable for use, including polymerase-based methods and ligation-based methods. Exemplary amplification techniques include the polymerase chain reaction method (PCR), the ligase chain reaction (LCR), ribozyme-based methods, self sustained sequence replication (3SR), nucleic acid sequence-based amplification (NASBA), the use of Q Beta replicase, reverse transcription, nick translation, and the like.
Asymmetric amplification reactions may be used to preferentially amplify one strand representing the target sequence that is used for detection as the target polynucleotide. In some cases, the presence and/or amount of the amplification product itself may be used to determine the expression level of a given target sequence. In other instances, the amplification product may be used to hybridize to an array or other substrate comprising sensor polynucleotides which are used to detect and/or quantitate target sequence expression.
The first cycle of amplification in polymerase-based methods typically forms a primer extension product complementary to the template strand. If the template is single-stranded RNA, a polymerase with reverse transcriptase activity is used in the first amplification to reverse transcribe the RNA to DNA, and additional amplification cycles can be performed to copy the primer extension products. The primers for a PCR must, of course, be designed to hybridize to regions in their corresponding template that will produce an amplifiable segment; thus, each primer must hybridize so that its 3′ nucleotide is paired to a nucleotide in its complementary template strand that is located 3′ from the 3′ nucleotide of the primer used to replicate that complementary template strand in the PCR.
The target polynucleotide can be amplified by contacting one or more strands of the target polynucleotide with a primer and a polymerase having suitable activity to extend the primer and copy the target polynucleotide to produce a full-length complementary polynucleotide or a smaller portion thereof. Any enzyme having a polymerase activity that can copy the target polynucleotide can be used, including DNA polymerases, RNA polymerases, reverse transcriptases, enzymes having more than one type of polymerase or enzyme activity. The enzyme can be thermolabile or thermostable. Mixtures of enzymes can also be used. Exemplary enzymes include: DNA polymerases such as DNA Polymerase I (“Pol I”), the Klenow fragment of Pol I, T4, T7, Sequenase® T7, Sequenase® Version 2.0 T7, Tub, Taq, Tth, Pfx, Pfu, Tsp, Tfl, Tli and Pyrococcus sp GB-D DNA polymerases; RNA polymerases such as E. coli, SP6, T3 and T7 RNA polymerases; and reverse transcriptases such as AMV, M-MuLV, MMLV, RNAse H− MMLV (SuperScript®), SuperScript® II, ThermoScript®, HIV-1, and RAV2 reverse transcriptases. All of these enzymes are commercially available. Exemplary polymerases with multiple specificities include RAV2 and Tli (exo-) polymerases. Exemplary thermostable polymerases include Tub, Taq, Tth, Pfx, Pfu, Tsp, Tfl, Tli and Pyrococcus sp. GB-D DNA polymerases.
Suitable reaction conditions are chosen to permit amplification of the target polynucleotide, including pH, buffer, ionic strength, presence and concentration of one or more salts, presence and concentration of reactants and cofactors such as nucleotides and magnesium and/or other metal ions (e.g., manganese), optional cosolvents, temperature, thermal cycling profile for amplification schemes comprising a polymerase chain reaction, and may depend in part on the polymerase being used as well as the nature of the sample. Cosolvents include formamide (typically at from about 2 to about 10%), glycerol (typically at from about 5 to about 10%), and DMSO (typically at from about 0.9 to about 10%). Techniques may be used in the amplification scheme in order to minimize the production of false positives or artifacts produced during amplification. These include “touchdown” PCR, hot-start techniques, use of nested primers, or designing PCR primers so that they form stem-loop structures in the event of primer-dimer formation and thus are not amplified. Techniques to accelerate PCR can be used, for example centrifugal PCR, which allows for greater convection within the sample, and comprising infrared heating steps for rapid heating and cooling of the sample. One or more cycles of amplification can be performed. An excess of one primer can be used to produce an excess of one primer extension product during PCR; preferably, the primer extension product produced in excess is the amplification product to be detected. A plurality of different primers may be used to amplify different target polynucleotides or different regions of a particular target polynucleotide within the sample.
An amplification reaction can be performed under conditions which allow an optionally labeled sensor polynucleotide to hybridize to the amplification product during at least part of an amplification cycle. When the assay is performed in this manner, real-time detection of this hybridization event can take place by monitoring for light emission or fluorescence during amplification, as known in the art.
Where the amplification product is to be used for hybridization to an array or microarray, a number of suitable commercially available amplification products are available. These include amplification kits available from NuGEN, Inc. (San Carlos, Calif.), including the WT-Ovation™ System, WT-Ovation™ System v2, WT-Ovation™ Pico System, WT-Ovation™ FFPE Exon Module, WT-Ovation™ FFPE Exon Module RiboAmp and RiboAmpPlus RNA Amplification Kits (MDS Analytical Technologies (formerly Arcturus) (Mountain View, Calif.), Genisphere, Inc. (Hatfield, Pa.), including the RampUp Plus™ and SenseAmp™ RNA Amplification kits, alone or in combination. Amplified nucleic acids may be subjected to one or more purification reactions after amplification and labeling, for example using magnetic beads (e.g., RNAClean magnetic beads, Agencourt Biosciences).
Multiple RNA biomarkers can be analyzed using real-time quantitative multiplex RT-PCR platforms and other multiplexing technologies such as GenomeLab GeXP Genetic Analysis System (Beckman Coulter, Foster City, Calif.), SmartCycler® 9600 or GeneXpert(R) Systems (Cepheid, Sunnyvale, Calif.), ABI 7900 HT Fast Real Time PCR system (Applied Biosystems, Foster City, Calif.), LightCycler® 480 System (Roche Molecular Systems, Pleasanton, Calif.), xMAP 100 System (Luminex, Austin, Tex.) Solexa Genome Analysis System (Illumina, Hayward, Calif.), OpenArray Real Time qPCR (BioTrove, Woburn, Mass.) and BeadXpress System (Illumina, Hayward, Calif.).
Prostate Classification Arrays The present invention contemplates that a Prostate Cancer Prognostic Set or probes derived therefrom may be provided in an array format. In the context of the present invention, an “array” is a spatially or logically organized collection of polynucleotide probes. Any array comprising sensor probes specific for two or more of SEQ ID NOs: 1-2114 or a product derived therefrom can be used. Desirably, an array will be specific for 5, 10, 15, 20, 25, 30, 50, 75, 100, 150, 200, 250, 300, 350, 400, 450, 500, 600, 700, 1000, 1200, 1400, 1600, 1800, 2000 or more of SEQ ID NOs: 1-2114. Expression of these sequences may be detected alone or in combination with other transcripts. In some embodiments, an array is used which comprises a wide range of sensor probes for prostate-specific expression products, along with appropriate control sequences. An array of interest is the Human Exon 1.0 ST Array (HuEx 1.0 ST, Affymetrix, Inc., Santa Clara, Calif.).
Typically the polynucleotide probes are attached to a solid substrate and are ordered so that the location (on the substrate) and the identity of each are known. The polynucleotide probes can be attached to one of a variety of solid substrates capable of withstanding the reagents and conditions necessary for use of the array. Examples include, but are not limited to, polymers, such as (poly)tetrafluoroethylene, (poly)vinylidenedifluoride, polystyrene, polycarbonate, polypropylene and polystyrene; ceramic; silicon; silicon dioxide; modified silicon; (fused) silica, quartz or glass; functionalized glass; paper, such as filter paper; diazotized cellulose; nitrocellulose filter; nylon membrane; and polyacrylamide gel pad. Substrates that are transparent to light are useful for arrays that will be used in an assay that involves optical detection.
Examples of array formats include membrane or filter arrays (for example, nitrocellulose, nylon arrays), plate arrays (for example, multiwell, such as a 24-, 96-, 256-, 384-, 864- or 1536-well, microtitre plate arrays), pin arrays, and bead arrays (for example, in a liquid “slurry”). Arrays on substrates such as glass or ceramic slides are often referred to as chip arrays or “chips.” Such arrays are well known in the art. In one embodiment of the present invention, the Prostate Cancer Prognosticarray is a chip.
Data Analysis Array data can be managed and analyzed using techniques known in the art. The Genetrix suite of tools can be used for microarray analysis (Epicenter Software, Pasadena, Calif.). Probe set modeling and data pre-processing can be derived using the Robust Multi-Array (RMA) algorithm or variant GC-RMA, Probe Logarithmic Intensity Error (PLIER) algorithm or variant iterPLIER. Variance or intensity filters can be applied to pre-process data using the RMA algorithm, for example by removing target sequences with a standard deviation of <10 or a mean intensity of <100 intensity units of a normalized data range, respectively.
In some embodiments, one or more pattern recognition methods can be used in analyzing the expression level of target sequences. The pattern recognition method can comprise a linear combination of expression levels, or a nonlinear combination of expression levels. In some embodiments, expression measurements for RNA transcripts or combinations of RNA transcript levels are formulated into linear or non-linear models or algorithms (i.e., an ‘expression signature’) and converted into a likelihood score. This likelihood score indicates the probability that a biological sample is from a patient who will exhibit no evidence of disease, who will exhibit systemic cancer, or who will exhibit biochemical recurrence. The likelihood score can be used to distinguish these disease states. The models and/or algorithms can be provided in machine readable format, and may be used to correlate expression levels or an expression profile with a disease state, and/or to designate a treatment modality for a patient or class of patients.
Thus, results of the expression level analysis can be used to correlate increased expression of RNAs corresponding to SEQ ID NOs: 1-2114, or subgroups thereof as described herein, with prostate cancer outcome, and to designate a treatment modality.
Factors known in the art for diagnosing and/or suggesting, selecting, designating, recommending or otherwise determining a course of treatment for a patient or class of patients suspected of having prostate cancer can be employed in combination with measurements of the target sequence expression. These techniques include cytology, histology, ultrasound analysis, MRI results, CT scan results, and measurements of PSA levels.
Certified tests for classifying prostate disease status and/or designating treatment modalities are also provided. A certified test comprises a means for characterizing the expression levels of one or more of the target sequences of interest, and a certification from a government regulatory agency endorsing use of the test for classifying the prostate disease status of a biological sample.
In some embodiments, the certified test may comprise reagents for amplification reactions used to detect and/or quantitate expression of the target sequences to be characterized in the test. An array of probe nucleic acids can be used, with or without prior target amplification, for use in measuring target sequence expression.
The test is submitted to an agency having authority to certify the test for use in distinguishing prostate disease status and/or outcome. Results of detection of expression levels of the target sequences used in the test and correlation with disease status and/or outcome are submitted to the agency. A certification authorizing the diagnostic and/or prognostic use of the test is obtained.
Also provided are portfolios of expression levels comprising a plurality of normalized expression levels of the target sequences described herein, including SEQ ID NOs:1-2114. Such portfolios may be provided by performing the methods described herein to obtain expression levels from an individual patient or from a group of patients. The expression levels can be normalized by any method known in the art; exemplary normalization methods that can be used in various embodiments include Robust Multichip Average (RMA), probe logarithmic intensity error estimation (PLIER), non-linear fit (NLFIT) quantile-based and nonlinear normalization, and combinations thereof. Background correction can also be performed on the expression data; exemplary techniques useful for background correction include mode of intensities, normalized using median polish probe modeling and sketch-normalization.
In some embodiments, portfolios are established such that the combination of genes in the portfolio exhibit improved sensitivity and specificity relative to known methods. In considering a group of genes for inclusion in a portfolio, a small standard deviation in expression measurements correlates with greater specificity. Other measurements of variation such as correlation coefficients can also be used in this capacity. The invention also encompasses the above methods where the specificity is at least about 50% or at least about 60%. The invention also encompasses the above methods where the sensitivity is at least about 90%.
The gene expression profiles of each of the target sequences comprising the portfolio can fixed in a medium such as a computer readable medium. This can take a number of forms. For example, a table can be established into which the range of signals (e.g., intensity measurements) indicative of disease or outcome is input. Actual patient data can then be compared to the values in the table to determine the patient samples diagnosis or prognosis. In a more sophisticated embodiment, patterns of the expression signals (e.g., fluorescent intensity) are recorded digitally or graphically.
The expression profiles of the samples can be compared to a control portfolio. If the sample expression patterns are consistent with the expression pattern for a known disease or disease outcome, the expression patterns can be used to designate one or more treatment modalities. For patients with test scores consistent with systemic disease outcome after prostatectomy, additional treatment modalities such as adjuvant chemotherapy (e.g., docetaxel, mitoxantrone and prednisone), systemic radiation therapy (e.g., samarium or strontium) and/or anti-androgen therapy (e.g., surgical castration, finasteride, dutasteride) can be designated. Such patients would likely be treated immediately with anti-androgen therapy alone or in combination with radiation therapy in order to eliminate presumed micro-metastatic disease, which cannot be detected clinically but can be revealed by the target sequence expression signature. Such patients can also be more closely monitored for signs of disease progression. For patients with test scores consistent with PSA or NED, adjuvant therapy would not likely be recommended by their physicians in order to avoid treatment-related side effects such as metabolic syndrome (e.g., hypertension, diabetes and/or weight gain) or osteoporosis. Patients with samples consistent with NED could be designated for watchful waiting, or for no treatment. Patients with test scores that do not correlate with systemic disease but who have successive PSA increases could be designated for watchful waiting, increased monitoring, or lower dose or shorter duration anti-androgen therapy.
Target sequences can be grouped so that information obtained about the set of target sequences in the group can be used to make or assist in making a clinically relevant judgment such as a diagnosis, prognosis, or treatment choice.
A patient report is also provided comprising a representation of measured expression levels of a plurality of target sequences in a biological sample from the patient, wherein the representation comprises expression levels of target sequences corresponding to any one, two, three, four, five, six, eight, ten, twenty, thirty, fifty or more of the target sequences depicted in SEQ ID NOs: 1-2114, or of the subsets described herein, or of a combination thereof. In some embodiments, the representation of the measured expression level(s) may take the form of a linear or nonlinear combination of expression levels of the target sequences of interest. The patient report may be provided in a machine (e.g., a computer) readable format and/or in a hard (paper) copy. The report can also include standard measurements of expression levels of said plurality of target sequences from one or more sets of patients with known disease status and/or outcome. The report can be used to inform the patient and/or treating physician of the expression levels of the expressed target sequences, the likely medical diagnosis and/or implications, and optionally may recommend a treatment modality for the patient.
Also provided are representations of the gene expression profiles useful for treating, diagnosing, prognosticating, and otherwise assessing disease. In some embodiments, these profile representations are reduced to a medium that can be automatically read by a machine such as computer readable media (magnetic, optical, and the like). The articles can also include instructions for assessing the gene expression profiles in such media. For example, the articles may comprise a readable storage form having computer instructions for comparing gene expression profiles of the portfolios of genes described above. The articles may also have gene expression profiles digitally recorded therein so that they may be compared with gene expression data from patient samples. Alternatively, the profiles can be recorded in different representational format. A graphical recordation is one such format. Clustering algorithms can assist in the visualization of such data.
Kits Kits for performing the desired method(s) are also provided, and comprise a container or housing for holding the components of the kit, one or more vessels containing one or more nucleic acid(s), and optionally one or more vessels containing one or more reagents. The reagents include those described in the composition of matter section above, and those reagents useful for performing the methods described, including amplification reagents, and may include one or more probes, primers or primer pairs, enzymes (including polymerases and ligases), intercalating dyes, labeled probes, and labels that can be incorporated into amplification products.
In some embodiments, the kit comprises primers or primer pairs specific for those subsets and combinations of target sequences described herein. At least two, three, four or five primers or pairs of primers suitable for selectively amplifying the same number of target sequence-specific polynucleotides can be provided in kit form. In some embodiments, the kit comprises from five to fifty primers or pairs of primers suitable for amplifying the same number of target sequence-representative polynucleotides of interest.
The primers or primer pairs of the kit, when used in an amplification reaction, specifically amplify at least a portion of a nucleic acid depicted in one of SEQ ID NOs: 1-2114 (or subgroups thereof as set forth herein), an RNA form thereof, or a complement to either thereof. The kit may include a plurality of such primers or primer pairs which can specifically amplify a corresponding plurality of different nucleic acids depicted in one of SEQ ID NOs: 1-2114 (or subgroups thereof as set forth herein), RNA forms thereof, or complements thereto. At least two, three, four or five primers or pairs of primers suitable for selectively amplifying the same number of target sequence-specific polynucleotides can be provided in kit form. In some embodiments, the kit comprises from five to fifty primers or pairs of primers suitable for amplifying the same number of target sequence-representative polynucleotides of interest.
The reagents may independently be in liquid or solid form. The reagents may be provided in mixtures. Control samples and/or nucleic acids may optionally be provided in the kit. Control samples may include tissue and/or nucleic acids obtained from or representative of prostate tumor samples from patients showing no evidence of disease, as well as tissue and/or nucleic acids obtained from or representative of prostate tumor samples from patients that develop systemic prostate cancer.
The nucleic acids may be provided in an array format, and thus an array or microarray may be included in the kit. The kit optionally may be certified by a government agency for use in prognosing the disease outcome of prostate cancer patients and/or for designating a treatment modality.
Instructions for using the kit to perform one or more methods of the invention can be provided with the container, and can be provided in any fixed medium. The instructions may be located inside or outside the container or housing, and/or may be printed on the interior or exterior of any surface thereof. A kit may be in multiplex form for concurrently detecting and/or quantitating one or more different target polynucleotides representing the expressed target sequences.
Devices Devices useful for performing methods of the invention are also provided. The devices can comprise means for characterizing the expression level of a target sequence of the invention, for example components for performing one or more methods of nucleic acid extraction, amplification, and/or detection. Such components may include one or more of an amplification chamber (for example a thermal cycler), a plate reader, a spectrophotometer, capillary electrophoresis apparatus, a chip reader, and or robotic sample handling components. These components ultimately can obtain data that reflects the expression level of the target sequences used in the assay being employed.
The devices may include an excitation and/or a detection means. Any instrument that provides a wavelength that can excite a species of interest and is shorter than the emission wavelength(s) to be detected can be used for excitation. Commercially available devices can provide suitable excitation wavelengths as well as suitable detection components.
Exemplary excitation sources include a broadband UV light source such as a deuterium lamp with an appropriate filter, the output of a white light source such as a xenon lamp or a deuterium lamp after passing through a monochromator to extract out the desired wavelength(s), a continuous wave (cw) gas laser, a solid state diode laser, or any of the pulsed lasers. Emitted light can be detected through any suitable device or technique; many suitable approaches are known in the art. For example, a fluorimeter or spectrophotometer may be used to detect whether the test sample emits light of a wavelength characteristic of a label used in an assay.
The devices typically comprise a means for identifying a given sample, and of linking the results obtained to that sample. Such means can include manual labels, barcodes, and other indicators which can be linked to a sample vessel, and/or may optionally be included in the sample itself, for example where an encoded particle is added to the sample. The results may be linked to the sample, for example in a computer memory that contains a sample designation and a record of expression levels obtained from the sample. Linkage of the results to the sample can also include a linkage to a particular sample receptacle in the device, which is also linked to the sample identity.
The devices also comprise a means for correlating the expression levels of the target sequences being studied with a prognosis of disease outcome. Such means may comprise one or more of a variety of correlative techniques, including lookup tables, algorithms, multivariate models, and linear or nonlinear combinations of expression models or algorithms. The expression levels may be converted to one or more likelihood scores, reflecting a likelihood that the patient providing the sample will exhibit a particular disease outcome. The models and/or algorithms can be provided in machine readable format, and can optionally further designate a treatment modality for a patient or class of patients.
The device also comprises output means for outputting the disease status, prognosis and/or a treatment modality. Such output means can take any form which transmits the results to a patient and/or a healthcare provider, and may include a monitor, a printed format, or both. The device may use a computer system for performing one or more of the steps provided.
CITATIONS Patents and Published Applications
- 1. US 2003/0224399 A1 patent application Methods for determining the prognosis for patients with a prostate neoplastic condition 2003 Dec. 4
- 2. US 2007/0048738 A1 patent application Methods and compositions for diagnosis, staging and prognosis of prostate cancer 2007 Mar. 1
- 3. US 2007/0099197 A1 patent application Methods of prognosis of prostate cancer 2007 May 3
- 4. US 2007/0259352 A1 patent application Prostate cancer-related nucleic acids 2007 Nov. 8
- 5. US 2008/0009001 A1 patent application Method for Identification of Neoplastic Transformation with Particular Reference to Prostate Cancer 2008 Jan. 10
Publications
- 1: Cooper C S, Campbell C, Jhavar S. Mechanisms of Disease: biomarkers and molecular targets from microarray gene expression studies in prostate cancer. Nat Clin Pract Urol. 2007 December; 4(12):677-87. Review.
- 2: Reddy G K, Balk S P. Clinical utility of microarray-derived genetic signatures in predicting outcomes in prostate cancer. Clin Genitourin Cancer. 2006 December; 5(3):187-9. Review.
- 3: Nelson P S. Predicting prostate cancer behavior using transcript profiles. J Urol. 2004 November; 172(5 Pt 2):S28-32; discussion S33. Review.
- 4: Bibikova M, Chudin E, Arsanjani A, Zhou L, Garcia E W, Modder J, Kostelec M, Barker D, Downs T, Fan J B, Wang-Rodriguez J. Expression signatures that correlated with Gleason score and relapse in prostate cancer. Genomics. 2007 June; 89(6):666-72. Epub 2007 Apr. 24.
- 5: Schlomm T, Erbersdobler A, Mirlacher M, Sauter G. Molecular staging of prostate cancer in the year 2007. World J Urol. 2007 March; 25(1):19-30. Epub 2007 Mar. 2. Review.
- 6: Mendiratta P, Febbo P G. Genomic signatures associated with the development, progression, and outcome of prostate cancer. Mol Diagn Ther. 2007; 11(6):345-54.
- 7: Reddy G K, Balk S P. Clinical utility of microarray-derived genetic signatures in predicting outcomes in prostate cancer. Clin Genitourin Cancer. 2006 December; 5(3):187-9. Review.
- 8: True L, Coleman I, Hawley S, Huang C Y, Gifford D, Coleman R, Beer T M, Gelmann E, Datta M, Mostaghel E, Knudsen B, Lange P, Vessella R, Lin D, Hood L, Nelson P S. A molecular correlate to the Gleason grading system for prostate adenocarcinoma. Proc Natl Acad Sci USA. 2006 Jul. 18; 103(29):10991-6. Epub 2006 Jul. 7.
- 9: Stephenson A J, Smith A, Kattan M W, Satagopan J, Reuter V E, Scardino P T, Gerald W L. Integration of gene expression profiling and clinical variables to predict prostate carcinoma recurrence after radical prostatectomy. Cancer. 2005 Jul. 15; 104(2):290-8.
- 10: Bueno R, Loughlin K R, Powell M H, Gordon G J. A diagnostic test for prostate cancer from gene expression profiling data. J Urol. 2004 February; 171(2 Pt 1):903-6.
- 11: Yu Y P, Landsittel D, Jing L, Nelson J, Ren B, Liu L, McDonald C, Thomas R, Dhir R, Finkelstein S, Michalopoulos G, Becich M, Luo J H. Gene expression alterations in prostate cancer predicting tumor aggression and preceding development of malignancy. J Clin Oncol. 2004 Jul. 15; 22(14):2790-9.
- 12: Feroze-Merzoug F, Schober M S, Chen Y Q. Molecular profiling in prostate cancer. Cancer Metastasis Rev. 2001; 20(3-4):165-71. Review.
- 13: Nakagawa T, Kollmeyer T M, Morlan B W, Anderson S K, Bergstralh E J, Davis B J, Asmann Y W, Klee G G, Ballman K V, Jenkins R B. A tissue biomarker panel predicting systemic progression after PSA recurrence post-definitive prostate cancer therapy. PLoS ONE. 2008; 3(5):e2318.
- 14: Shariat S F, Karakiewicz P I, Roehrborn C G, Kattan M W. An updated catalog of prostate cancer predictive tools. Cancer 2008; 113(11): 3062-6.
EXAMPLES To gain a better understanding of the invention described herein, the following examples are set forth. It will be understood that these examples are intended to describe illustrative embodiments of the invention and are not intended to limit the scope of the invention in any way. Efforts have been made to ensure accuracy with respect to numbers used (e.g., amounts, temperature, etc.) but some experimental error and deviation should be accounted for. Unless otherwise indicated, parts are parts by weight, temperature is degree centigrade and pressure is at or near atmospheric, and all materials are commercially available.
Example 1 Identification of Target Sequences Differentially Expressed in Prostate Disease States Tissue Samples. Formalin-fixed paraffin embedded (FFPE) samples of human prostate adenocarcinoma prostatectomies were collected from patients at the Mayo Clinic Comprehensive Cancer Center according to an institutional review board-approved protocol and stored in the Department of Pathology for up to 20 years. For each patient sample four 4 micron sections were cut from formalin-fixed paraffin embedded blocks. Pathological review of FFPE tissue sections was used to guide macrodissection of tumor and surrounding normal tissue. Patients were classified into one of three clinical disease states; no evidence of disease (NED, n=10) for those patients with no biochemical or other clinical signs of disease progression (at least 10 years follow-up); prostate-specific antigen biochemical recurrence (PSA, n=10) for those patients with two successive increases in PSA measurements above an established cut-point of >4 ng/mL (‘rising PSA’); and systemic disease (SYS, n=10) for those patients that had ‘rising PSA’ and developed metastases or clinically detectable disease progression within five years after initial prostatectomy. Clinical disease was confirmed using bone or CT scans for prostate cancer metastases.
RNA Extraction. RNA was extracted and purified from FFPE tissue sections using a modified protocol for the commercially available High Pure FFPE RNA Micro nucleic acid extraction kit (Roche Applied Sciences, Indianapolis, Ind.). RNA concentrations were calculated using a Nanodrop ND-1000 spectrophotometer (Nanodrop Technologies, Rockland, Del.).
RNA Amplification and GeneChip Hybridization. Purified RNA was subjected to whole-transcriptome amplification using the WT-Ovation FFPE system including the WT-Ovation Exon and FL-Ovation Biotin V2 labeling modules, with the following modifications. Fifty (50) nanograms of RNA extracted from FFPE sections was used to generate amplified Ribo-SPIA product. For the WT-Ovation Exon sense-target strand conversion kit 4 ug of Ribo-SPIA product were used. All clean-up steps were performed with RNAClean magnetic beads (Agencourt Biosciences). Between 2.5 and 5 micrograms of WT-Ovation Exon product were used to fragment and label using the FL-Ovation Biotin V2 labeling module and labeled product was hybridized to Affymetrix Human Exon 1.0 ST GeneChips following manufacturer's recommendations (Affymetrix, Santa Clara, Calif.). Of the 30 samples processed, 22 had sufficient amplified material (i.e., >2.5 ug of WT-Ovation Exon product) for GeneChip hybridization.
Microarray Analysis. All data management and analysis was conducted using the Genetrix suite of tools for microarray analysis (Epicenter Software, Pasadena, Calif.). Probe set modeling and data pre-processing were derived using the Robust Multi-Array (RMA) algorithm. The mode of intensity values was used for background correction and RMA-sketch was used for normalization and probe modeling used a median polish routine. A variance filter was applied to data pre-processed using the RMA algorithm, by removing target sequences with a mean intensity of <10 intensity units of a normalized data range. Target sequences typically comprise four individual probes that interrogate the expression of RNA transcripts or portions thereof. Target sequence annotations and the sequences (RNAs) that they interrogate were downloaded from the Affymetrix website (www.netaffx.com). Supervised analysis of differentially expressed RNA transcripts was determined based on the fold change in the average expression (at least 2 fold change) and the associated t-test, with a p-value cut-off of p<0.001 between different prostate cancer patient disease states. Linear regression was also used to screen differentially expressed transcripts that displayed an expression pattern of NED>PSA>SYS or SYS>PSA>NED and genes were selected with a p-value cut-off of p<0.01 for two-way hierarchical clustering using Pearson's correlation distance metric with complete-linkage cluster distances.
Archived FFPE blocks of tumors were selected from 30 patients that had undergone a prostatectomy at the Mayo Clinic Comprehensive Cancer Center between the years 1987-1997, providing for at least 10 years follow-up on each patient. Twenty-two patient samples had RNA of sufficient quantity and quality for RNA amplification and subsequent GeneChip hybridization. Three clinical categories of patients were evaluated; patients alive with no evidence of disease (‘NED’, n=6), patients with rising PSA or biochemical recurrence (defined as two successive increases in PSA measurements) (‘PSA’, n=7) and patients with rising PSA and clinical evidence of systemic or recurrent disease (e.g., determined by bone scan, CT) (‘SYS’, n=9) after prostatectomy. No statistically significant differences between these three clinical groups were apparent when considering pathological factors such as Gleason score or tumor stage (Table 1). As samples from older archived FFPE blocks are typically more degraded and fragmented than younger blocks, the distribution of block ages was similar in the three clinical groups so as not to skew or bias the results due to a block age effect. Fifty nanograms of RNA extracted from FFPE sections was amplified and hybridized to whole-transcriptome microarrays, interrogating >1.4 million probe target sequences measuring RNA levels for RefSeq, dbEST and predicted transcripts (collectively, ‘RNAs’).
Table 3 displays the number of target sequences identified in two-way comparisons between different clinical states using the appropriate t-tests and a p-value cut-off of p<0.001. At total of 2,114 target sequences (Table 3) were identified as differentially expressed in these comparisons and a principle components analysis demonstrates that these target sequences discriminate the distinct clinical states into three clusters (FIG. 1A).
A linear regression filter was next employed to statistically rank target sequences that followed a trend of either increased expression with poor prognosis patients (i.e., SYS>PSA>NED) or increased expression in good prognosis patients (NED>PSA>SYS, alternatively decreased expression in poor prognosis patients) (Table 4). FIG. 1B depicts a two-way hierarchical clustering dendrogram and expression matrix of top-ranked 526 target sequences and 22 tumor samples. Patients in the ‘PSA’ clinical status category displayed intermediate expression levels for genes expressed at increased levels in SYS (n=313) and NED (n=213), respectively (Table 4). FIG. 1C depicts a two-way hierarchical clustering dendrogram and expression matrix of 148 target sequences and 22 tumor samples. These target sequences were a subset of the differentially expressed transcripts (Table 3) filtered using a t-test to query ‘recurrent’ (i.e., ‘SYS’) and ‘non-recurrent’ (i.e., ‘PSA’ and ‘NED’) patient samples (Table 5).
The expression levels of these genes were summarized for each patient into a ‘metagene’ using a simple linear combination by taking the expression level and multiplying it by a weighting factor for each target sequence in the metagene signature and combining these values into a single variable. Weighting factors were derived from the coefficients of the linear regression fit analysis (Table 4). FIG. 2 shows a histogram plot of the metagene expression values for the summarized 526 target sequences in each of the three clinical groups. This 526-metagene achieved maximal separation between clinical groups and low variance within each clinical group. Metagenes comprised of smaller subsets of 21, 18 and 6 target sequences were also generated (FIG. 3, Tables 7 and 8). The distinctions between clinical groups with respect to the metagene scores were preserved, although increased within-group variance was observed when using fewer target sequences (FIG. 3).
Next, Patient outcome predictor (‘POP’) scores were generated from the metagene values for each patient. For the 18-target sequences metagene, this entailed scaling and normalizing the metagene scores within a range of 0 to 100, where a value of between 0-20 points indicates a patient with NED, 40-60 points a patient with PSA recurrence and 80-100 points a patient with SYS metastatic disease (FIG. 4). In contrast, Gleason scores for patients could not be used on their own to distinguish the clinical groups (Table 1).
Using the Nearest Shrunken Centroids (NSC) algorithm with leave-1-out cross-validation, smaller subsets of RNA transcripts were identified that distinguish ‘recurrent’ (i.e., ‘SYS’) and ‘non-recurrent’ (i.e., ‘PSA’ and ‘NED’) disease (Tables 9 and 10). NSC algorithm identified 10- and 41-target sequence metagenes used to derive patient outcome predictor scores scaled and normalized on a data range of 0-100 points. FIGS. 5 and 6 depict box plots showing interquartile range and distribution of ‘POP’ scores for each clinical group. A 148-target sequence metagene (Table 5) was similarly used to derive ‘POP’ scores depicted in FIG. 7. T-tests were used to evaluate the statistical significance of differences in POP scores between ‘recurrent’ (i.e., ‘SYS’) and non-recurrent (i.e., ‘PSA’ and ‘NED’) patient groups (indicated in the figures) and show that increasing the number of target sequences in the metagene combination increases the significance level of the differences in POP scores.
The data generated from such methods can be used to determine a prognosis for disease outcome, and/or to recommend or designate one or more treatment modalities for patients, to produce patient reports, and to prepare expression profiles.
TABLE 1
Clinical characteristics of different clinical status patient groups evaluated.
Note Chi square tests for homogeneity reveal that the three clinical groups
do not show significant differences in terms of patient composition based
on known prognostic variables such as pathological TNM stage or Gleason
score. Also, the block age of the samples was not different between
clinical status groups; so that sample archive age effect is mitigated
(i.e., older samples have more degraded, fragmented nucleic acids that
could skew or bias results if not evenly distributed in clinical status
patient groups).
NED PSA Systemic X2 Tests for
(n = 6) (n = 7) (n = 9) Homegeneity
Pathological T2N0 2 3 3 p < 0.07
Stage T3aN0 1 4 1
T3bN0 0 0 3
TxN+ 3 0 2
Gleason Score 7 2 7 4 p < 0.06
8 3 0 2
9 1 0 3
Block Age 10-14 3 4 5 p < 0.9
Group (years) 13-15 1 1 2
16-20 2 2 2
TABLE 2
Comparison of differential expression between patient clinical
status groups. Two-way comparisons for differential expression
using the following statistical criteria: a) at least 2-fold mean
difference in expression between comparison groups;
b) expression levels >50 intensity units of a normalized data
range (approximately the mean expression level across all
transcripts in all samples) and c) significance cut-off of
p < 0.001 determined using a t-test.
Clinical Differentially
Status Comparison Expressed RNAs*
NED vs PSA 316
PSA vs NED 442
NED vs SYS 213
PSA vs SYS 194
SYS vs NED 269
SYS vs PSA 323
SYS vs NED & PSA 310
NED & PSA vs SYS 77
*Differential Expression is indicated by at least 2-fold change expression between mean of clinical status variable and comparison variable; also mean value >50 intensity units of a normalized data range and p < 0.001 calculated using a t-test
TABLE 3
Differentially expressed RNA transcripts identified from comparison
tests described in Table 2. Sequence listings are annotated with the
Affymetrix Human Exon 1.0 ST probe selection region ID, proximal
annotated gene from RefSeq, and overlap with coding sequence (CDS).
SEQ
ID Gene
No Affy. ID Symbol CDS RNA Sequence
1 3509278 — NO ctggtccctctcctgatagagtttcaggtttgccctgatgatctagatgaagcaaagtgtggtgacacttcgctgaatgctctgtcagtgtgcctagaaatagag
tctctatcagggccgtttgcttcctatcacactc
2 2750440 — NO ggcatgatctaggctaactccctggc
3 3498665 — NO tgggcaagagcttttgtatgtttccag
4 3159532 — NO cccaacacggtgcagccgatttatttatttttccctcagcatttttaggtggattgactgggatgctttattcaactcagggacgcaccacgaatatgttttttg
5 3521600 UGCGL2 YES tggcgccagcgaaagccacgaacgtg
6 3820597 — NO gctgggcgcagcgttctgaggggatgtggggtctgggaggtgtctcgaggtgagagctccaagtcacgg
7 3955349 — NO gtggcgcaatattgcaatacagctcactgctacagccccaggcttaagtgatcttcttgcctcagtctcccgagtagctggaaccacaatctcataccaccac
gccccacgcctggtaaatttttaaatgtttttgtaaagacagggtactgctgtgttgcccaggctggtctctaattcctagtctcaagcgatccttccgctttggcc
tcccaaagcactgggattacaggtgtgagccactgtgcccagccctgctctaggttttcatttggatttgctgcctagtggaaggcacaggatggggcagtg
ccttctgccagtgagggaggctccaggtagatgtcattgctgaactggagctcccctgg
8 3204523 PIGO YES tgcttcctcttctacgctggcattgccctcttcaccagtggcttcctgctcacccgtttggagctcaccaaccatagcagctgccaagagcccccaggccctg
ggtccctgccatgggggagccaagggaaacctggggcctgctggatggcttcccgattttcgcgggttgtgttggtgctgatagatgctctgcgatttgactt
cgcccagccccagcattcacacgtgcctagagagcctcctgtctccctacccttcctgggcaaactaagctccttgcagaggatcctggagattcagcccca
ccatgcccggctctaccgatctcaggtt
9 3373899 SLC43A1 NO agccatggccgtagatttataaataccaagagaagttctatttttgtaaagactgcaaaaaggaggaaaaaaaaccttcaaaaacgccccctaagtcaacgct
ccattgactgaagacagtccctatcctagaggggttgagccttcttcctccttgggttggaggagaccagggtgcctcttatctccttctagcggtctgcctcct
ggtacctcttggggggatcggcaaacaggctacccctgaggtcccatgtgccatgagtgtgcacacatgcatgtgtctgtgtatgtgtgaatgtgagagaga
cacagccctcctttc
10 3707645 RABEP1 YES atggcgcagccgggcccggcttccc
11 3860354 LOC100127980 NO ttcagattcacgagggtaatccagatgaaggtatatcattgtacctggcccgcatcactcagtaactgtcacctttgatttattgatttacttgagatggagtttggt
tctgtccccgaggccggagtgcaatggcgtgatctctgctcactacaacctctgcctcccaggttcagagtgattctcctgcctcagcctctttagctgggatt
acaggcacccaccaacatgcccagctaatttttgtatttttagtagagaggagctttcaccataatggccaggctggtcttgaacctcaaatgatctgcccacct
tggcctcccaaagtgctaggattacaggctggagctacagagcccagcctgtcaccttgatttaaatgaatgcagctttcttggtgtcttgatgtttgtgaatttct
gtggagtttgatactgctccttttgctgcttgtttttccagagtccccttatcacttgacgtgctgttata
12 2406772 MRPS15 NO tgtcgtgacagcctctctttggggccagcttctgcttttgcccccatctttgcagtacagggggtaaattaaacaagaggatgcctgaatgaacgatatcctgg
gttcttgagagacaagtgggagctgataattctgaaaattcattagtcaaagcatggagataaaggtggcagcaggaaggggagaggcaaggagtagacc
cgtgacagttttagaatcttatttgtgccaaaatactttactgcattggcttggacctctaatacaatgttgaattgttaaccatgatagcactgtatcctggtctaatt
cctgaattgaatggctagtcttaccattaagaatgctatttgcggccaggc
13 3881324 HM13 YES ttatgaatttgacaccaaggacctggtgtgcctgggcctgagcagcatcgttggcgtctggtacctgctgag
14 3271321 — NO aggagcaggtcgtcaagtccaccaggatggaatgctcagtaggagaaattgcgctgtggggccatttgaggcgcctgtccatgcgggtccgtcctggccc
ttctgaa
15 3316374 — NO aggcattacgccagctcccggatgcctcagcctcgtgaattcggggtaggacgctcagggcccatggtcagcacagcgggtgggtgggtttcagcgtggt
cacttctccaggggtgcataattgagcagcttctcgatcaggtccacgtg
16 3333695 — NO gttgaggagcttgatgctgcagtgagattgtgccactgcactccagcatgggtgacatagcaagactgcctcagggggaaaaaaaaaaaaaaacaccaaa
aaaaaaggtatatggaccctagttttggccaggctg
17 3930855 — NO gtggctcactgtagcgtcagtctcc
18 2945934 CMAH NO ggacgattcgtttctatttgacccaagactgatgctgcgtggtgaaggagaggaactgcgttccaggcagaggaagtccagatgcgcaagagcagagatg
ggagggacagcacagtggcttctcagaattgaatatggtgttagacttctaaaagagctgtggtagagggagaaaactgtcaaaggaaatcagtaactgtta
aaggaaaataccttaaacgtcctgttttcaggctgactaatgccttaggggagcaaatgagcaaca
19 2581405 — NO ttggtatgtagggttcgtatgaatgaaacgtgactaccagggcagataatgaaaggctttcaatcccagagtaagagatatagggccaggc
20 2465840 — NO atgtggcacaatttacgaaaaccaaagagaggctatgctgagtccctacaccaccaagaccgtgatgttctgcccactcgcctcctgatggcctgtggggat
agaccagcttccagatttcacacagatgggctgtatggaggaggc
21 3431367 — NO cgatctctcatggtgggctcaagtgatcctcccatctcagcctcccaagcacctgggactacaggtgcacatcaacacacccggataatt
22 3458114 NACA NO gggccactgttcctcaagcatctaaagggcttccagcaaagaaaggccccacagctctgaaagaagtacttgttgccccagctccagaaagcacgccaat
catcacagctcccactcggaaaggtccacagaccaaaaagagttctgctacttcacctcctatatgcccagatccctcagctaagaatgg
23 3875254 — NO ttctccctcagaccaagttaaactgtttttttcccaagagctaggaatcatatctgatcacactgggacttcccttcactgtcagtctaagagtttgcatttttgaggt
ttaggaaaagggaaaaaaaaggaagaaagaaagaaattgtatctgagaacaaagaagctgccacatggtccctcggtatca
24 2515646 ITGA6 YES tgtgctcaccgatatgaaaaaaggcagcatgttaatacgaagcaggaatcccgagacatctttgggcggtgttatgtcctgagtcagaatctcaggattgaag
acgatatggatg
25 3202904 — NO tgagggcgttggaccacacacccttgaaaaaggcctcgccccgctcatctctgaagatcttcctccaacagtcgacggtgcccgtgtacatgatgtcagctc
ctttgcgccgggactgcatcatcgtccgccgccgcactgtgtcgaagggttag
26 2768304 NFXL1 YES ctgtccaccttgtgatcaaaactgtggacggactttag
27 3736631 — NO aaagcggtcactggccatatgatgcggagatggttttatctgaggcctgagaaccaacagatgtgcctgcgccctggcctgtgcagctgtgggcagatgtg
tccccaggggcctgccctcactcgtgaccatgcaataccctgcaacataaacattttcttttccaaggatctgcaggggtggacatgatgctccaggcacag
agtaggaagaaaagggggtgacctggggttcccagcaaacaggtccacctcatgctcactgcgtt
28 2787529 INPP4B YES tgtgccctggtatgtgaatgtacagccccggaaagtgtgagcggaaaagataacttacct
29 2980188 — NO tttccccacaaattgctgatgtacc
30 3273235 — NO caatattcactgtgaggtcaagctcctagaggtaaaaactcaaaactgtggcagccctcccccgtgactgggtccctctgaagtttctaactctcagagttgtc
catactgggcatctagcgattcat
31 3402918 USP5 YES gaggaaaagatcaagtgcctggccacagagaaggtgaagtacacccagcgagttgactacatcatgcag
32 3529227 — NO cgaagtgggtctccaaattccgcgcccaccccaccgcccgagaagcccactacgcatgcgtccgcaccccaccggcgccccttcctattgagcatgcgc
gggagccccacctatttctctctaccgtttcctccccctacctggtaccccatccctagctcagccattgcttttttttccacgaccctccgctgtttcttccgcga
gcttcct
33 3839571 KLK2 NO ggagggaatggctgtgtcccacaggaataacagcgggatgcttcc
34 2697538 CEP70 NO gagactcgttgggtgatcatttcattgagatcaacctgaatgaccaggtgtaaagtgcaagagtaatatgctatgactga
35 2521076 — NO ggatccatgccagacaacgcacattctgcagacactggttactccagtggctccttactggaaacatataatatcagtgataagtgctgtgaagaaaataaaa
caatgatgtgctggtatggatttttaacttttttatgtgatgaaccacagaatgatggttttaaatgtatgaaatacatagaattgcaacagaaaccagttatgaaat
aatgaagatattaaatatgacatctatattttagtaaagcattagtgaggactgtaaatgatctttaaagaatttggcttaaatttaatctaaaattgctatcaggtatt
tcacatcgctgtaatttttgcctgcattcgtaactgaagagataagtaaatgtcagaggttaagataaatctttttctttttttacctgtccatatttacaaacattctgc
gttccgtacatagacgcctggataagaacccctgtgcaagaatgactttggtgctactttaaaaaaagtggttggggaagacctcataggaaatgacatcaat
aatagattgcatgataacctatactagttcttactgttaccaatttaaattctaactgcttaaaagctaacacggtccttccctttttttgagcacctgatttgaagtac
tttgagtaggcctcaagtgtcgtatgcaagta
36 2811029 — NO ctgagttctgatttggagcagcctgtcgcaataccaaatcacctttgaataaacttatcctctcagcttttattgttcagaattgatttcgaggatagaaattccattt
ccttgtcatatatacctgagccgttgcatcaaattgtcaga
37 2735920 — NO gggtgtagcgcaccaagcatgagctgaa
38 3843767 ZNF135 NO aataacctagcatggggcggcactaaatggctgcaggaaagccgagtcttcttccacatccggcggctcccctcggatgcgagcgctggcccagggtgt
gtttacagaggtgagggcttcccgtggacccttctcgttgggagcgcttagcctcaggagcggattcagggcacaggcagaggacgtccacaaacacca
caggaagccgccacccaggggcgtggaaaggcccaatgcctcgtctgggattcacggccggcaaagcggcccctccggaacgggacagcacagcg
gctcacctctgcgcctctgggggtgcggggggagcctcgccctccacgctctctgggggaccgcccgccctagcccccgcctgggcttcgcgggtgga
cggttgggggccccgggcgccccccagcgcgtagcttttctccttctcgtgggtcttctggtgctcggctagggccaggctgaagtggaaggtcttccagc
agccctgacaggcgtagcgcttccggccgccatggctgctgtggtgctccatcaggtgcgagagccacgcgaaggcctccccgcactcgccgcaggca
tagggcttcccgcgggacaagcccggctcgtcagccccagggccctgcccggcctccagccctgcgctgtcgccggagctagagacgccctcgaggct
ctgcccgtccccatcctcggggtgcggcctcttggttcccagtttcgccgtgcccctgtccggggcaggctgctggatgacggactgcctctgcgatccggt
ggcagagtcggactccgcgtcctgggggtcctgcgggtccggggccttcccaggctgctcttcctcctcctcagtggtgcccgacgggggatcggcaag
ggcgtccccagggggcgcctccgtaggcagctcaggcagcacccccgcgggggcggcctcctcgcaggcgcacccagcgctctcctgccgcctccc
gccttctggaacaaggtcagagccctagcgtgagcgccc
39 3895275 ProSAPiP1 NO tgggcactcggcattttgacacatgtcctgtcaaaaggccagagtccccagtgtcccctcccctccatctctcttccccatagaccccataaccccagaccaa
agaggttctctaagcagctgtgaccaggttcctccctccccacctgccctcctagctccagcactgcccccgtggcagcccacttggacccccctaaaagg
agggaataggaggagggcagggtgagtgggggcaatcctaggtggtgggggagtcatgctccctttctcggcacccccttgttggagatggaggcagca
gacgtgcagtgccataaggtgccccagtccttctggaggcctgggctgctactgttggccaccctgtgtctagtgatgctctctgtgctcacctcctaggccat
ggagcctgagggggcctgcaccaggtttgctgaaactgacagagcctgggctccagacctctctccctcctacagtgctctccctccctgggcagattggc
aggacaagtgggagcagatggcctgcctttggctgagagggctacctgcccagcccctcccccaacaagatctcttggactcaggcctcagagcctggc
ctggttgtgagtgtgtgtccctgtgtgtgtgttgcgggaggggaggactggggctggaagtccagcacccagggaagatctgtcctcctgttcttgggaagc
gttgcctgacggcttctcggctctaccctcacccttctggccaggatcccgcagggcaacagccccatctgcttggctgaccccacacccaggaccactgt
ccggctctaacacagctattaagtgctacctgcctctcaggcactctcctcgcccagtttctgaggtcagacgagtgtctgcgatgtcttcccgcactctattcc
cccagcctctttctgctttcatgctcagcacatcatcttcctaggcagtctcttccccaaagtctcaccttttcttccaatagaaaattccgcttgacctttggtgcac
40 4031098 CYorf15B NO tcacttaacatagtgccagggcatgcaattttgtttcttactctctggatgtgggatatgcgagtgtgtgtgtgtgtgtgtgtgtgtgtgtattaagctttctgtttctg
atgaaattttcatatgaaatttactggagataagattaaattagtggaaaaacaagataattttgctttctatgtagtggtcaccaagttaaagaattgtgccagtta
ttaggcaagataggctttgagatttagggacagttaaattttacaccaacttagtgaacatgagacttctacctagtgttacatttcatttttaaataagcaatttaaa
aattggtaaatgatttgtttactttgattatattctggtataattttctgacaaaattatctgtgtcttggtcagcattgttgctagaatatgtattcagattttgtctgtcca
taattgagaacacagaaaaaatctaatttgactatacccatttacccccatggaaatgaaactatattctatgaatgaaaaatgattttaataatgtggtgtattaca
ttttcttcattcaagtaatgtaggccctgagtagagcatgttatgaatatttagttccttagtgttttctcattcaagcctctcatattgaatgagtctagggtttggag
agatgtttcacacagcatgtctcttcagtgcaagctgacagatatcagtgcacaattaaagaaacttaattgcacctttcaacttggagtataaattttgtatgtatc
tatgtatatctatgtgtgtattttgtggtttaaggcttatttacataatatgtgacattttacctcagaaattcagtgactgaatttcacagctgcttcccatgcatcttta
ttatctatgtttctgaaaaactcaaatactaactaatctcttttcttcccttagctgttcctttcctgtggttttaaaaaagtgaccagaaactaggtctctattttcattg
ctttgctgcatattcttttaacctgcttttatc
41 2927637 KIAA1244 YES gtcccacaggatttcgggaatcaag
42 3839575 KLK2 YES ttctgaagcatcaaagccttagaccagatgaagactccagccatgacctca
43 2566620 TSGA10 NO atccattgatggtttgatagtgggctgggaaggaaagctgtgttcctccacattaggcagcaaa
44 2959903 LOC728052 NO tcatttatttgacagtgcatgtctgcaatgccgtgctcatcaatgat
45 3100926 — YES agtaacagctatccaccaatgtcaatccatac
46 3853655 — NO gcaggcaatatctccgcacctttaat
47 3947544 — NO ctgctggaacgacaccaactctttgcctcccatccttggttggatatgatttgaaatttggtaatgtgtctctacttgaaacagatgcactgtttggatgttttcagg
tcggtgatctacttgtccagtttgatcgctaccagaag
48 2466070 ZNF692 NO ggattagtccgctccactcactgtcagcattaagtgggggtgcccaagacggggtggatggggggcgccctccagacctctgaccacggcctcaccgcc
actcgacccaactatgaagagcgcccccagctgcacgccaggacacgacctttccttcccctagaaaccagtaaaggccgctgccctattcaagatgaaat
gtgtggaccgcccccagcccagttgaaatttcccgtgaaagtctctcgccccttccccacagctccacttcagtggactggagggcgcaggcctttgttctg
actgcttctgtctgcctgcctcccacccgacgacactcacatggtagcgctgagcttcaacaccctgta
49 3065818 RELN YES ttcgataggtttgaggggaagctcagccctctgtggtacaagataacaggtgcccaggttggaactggctgtggaacacttaacgatggcaaatctctctact
tcaatggccctg
50 3332183 STX3 NO ctgatttcactccagactggtgtggccacccttgtcttcagatgagaat
51 3681410 PARN YES ctgtcaataccagcaaatatgcagaaagctatcggatccaaacctatgctgaatatatggggagaaaacaggaagagaagcagatcaaaagaaagtggac
tgaagatagctggaaggaggctgacagcaaacggttaaacccccagtgcataccctacaccctgcagaatcactattaccg
52 3873342 — NO gccacaggagggtttaaacacagcagtaatgagactttatttctgctgggaaaacattgccgttattgccc
53 2572055 — NO gtgcctgagagaaaacggcctaatcgaaaacgtccgcggcatacatccattcttaaaacttgagtggctgcttttctgggtggaaaagagcggtatcagaca
gggtgagcagtcggggaacggatgaacaaagacttgcaccgtggccctgatgcctttgttccgagttctattcagttgtacttgtgcgttgttacaggacttta
gaatgcagccctgccccccaacccccacctcccagggccgacctgtgctcctaggaaggcaaacctc
54 3434549 MLEC NO tggcacctcttgcatccaggcagtcttgtgagatgggggcacatagcactggggaaagcagaactccattctcacctctattttgagcttcagtgctttatttca
gtatgaggaaaaacaacaacaaactgaagtgcgctttccgtcctttcaaaggacaactgtcgggaagggagagccgagttgcgaggtaggaggggagca
ctggcagggagagacattcttgactcctctcttccctggtgtgttgtgatccagggaatgaaaagaaatttgaccctggattggttctctccttggacttaagga
atcttaccttttccttccacaaagttctcccaggcaaggaccagctgcccattctgagcccagggcagcctcttcaaccattattgg
55 4007482 — NO tccaagcaggtcttcgtagtagagaacgaaccagccctcgatcaccaggtgaatgaacccacacactgcaaaccagcacagggacagtcgccgccaagt
ccccaatgggacaaccgcagcacgacctgacaacagccatgtggtcacgactaagacccctgtgacagagaagaggccagccagtatatgccaggtgg
ggcggtcattaggtacaaagttgtc
56 2751391 CLCN3 NO cccgagttagagcatggattcagttttagtcttaagggggaagtgagattggagatttttatttttaattttgggcagaagcaggttgactctagggatctccaga
gcgagaggatttaacttcatgttgctcccgtgtttgaaggaggacaataaaagtcccaccgggcaaaattttcgtaacctctgcggtagaaaacgtcaggtat
cttttaaatcgcgatagttttcgctgtgtcaggctttcttcggtggagctccgagggtagctaggttctaggtttgaaacagatgcagaatccaaaggcagcgc
aaaaaacagccaccgattttgctatgtctctga
57 2871645 — NO ctctgtggggttcggttccactttgtagttcgggtttgtaatgtaaagaataatgggaaactggtctaattatgagagttaagagagtagaggcctgtagttg
58 3629576 PARP16 NO ttagccataatagggcccggtacgatttgggagtgacatttctgtaaagaagaggaaaaatcatttttctataatttgtaaagttgtgaaagagccactaccaca
gtttttacattgattattggaacatttc
59 2545930 IFT172 YES tggtggctacaacattggcaccgtcagccatgagagccgtgtggattggctggaacttaatgagactggacacaagctcctcttcag
60 2569734 — NO ttcccttggctttggacatgtgagggaagtaggtatccgctgcctggggaaagtcaacaggacccctcctccccgtacctcttggtatacaaagctgagcgg
tg
61 2832639 PCDHGA10 YES ttactttgaagtttgcggcatgatggtggaaagtgtaaatgctaaaacactgatgagtagaatttg
62 3113343 — NO ggctgattgaccttgactggcctcatgtatgtgtctcaaagttggctggggctgtcggctgaaattccttagttctactccacatggcctttccccatggccagc
ccaggctgagatctgagattgaagagggtgagaacagaaagtacaagatcttcttttgacttgaaagctagcccagaatcgagggaaataaaccccaccttt
tgatggaaggagcttcaaagaatttgtagtcatttccaatccacgaagagtaggtacccactatttgttgaataaagccctattgaaagctttttagctatccaga
tgcaaattactggccaacctttgggtagaattataaaattctgcccaaaattctaccaaattactggtacttgtaaaattctaccaaataactggccaacttttggg
tagaattgtaaaaattaagttgtaaataaagcctattgcctaacaggaacttcaaagtcagagaatcctaaaatgattgtgctacacagggccacatagagcac
agctttgtctttttttttttgagatggagtctcgctctgtcccccaggctgaagtgcagtggcgcaatctttgctcaaggcaacttctacttcccaagttcaagcaat
tcttctgtttgagcctcctgagtagtgggactgcaggcatgtgccactatgccccattatgtatttttagtagagatgagatttcaccagattggccaggctggtc
tcgaactcctgacctcaaatgatctgcctgcctcggcctcccaaagtgttgggattataggcatgagccaccatgcccgcccgcttcgtcttttcactggacta
atgaagatacaggtgtggaatggtttcacagcatgcccaacctcatgaggcttgttgggtcagagcttgtgccagatgccagtcttctgccttccagtcttata
gttgttacgctatagccttctgcagtggatggtaacgtggccaaaataagcctttggttttggagtattcgtaaaatg
63 3875673 — NO gggaactaacgccttccagaacagaaatatgtggtccgatgagtattgaatgcaacttaaaatctagttggaatgtgatggataagaagagacccaaagtcat
caacaagccttctcatgaactttcagtcattaaccttcctatatagtaaggacagaaatgatgatttaagccatcttaggcaaggcagtgctaacaatatgctttt
gtaaagtcaccatccggtg
64 3959071 — NO ttctctaattctaggcctgccgtttttctctgtgagtggacctgatctccttttgctttggctcccagagttccctattcgcttctccttgtcccctgagtcctgctctcc
ctcctctggataaccccttccagcccttcacttctccctcctgttatttgctggaatggctaattggctgacccccccacccagtccccatgggagaccccctcc
agcaccagaagaggcagactaacattttctttggtagcagaatgtaaaattgtaaaatgtgaaagataggagagaaacatcattaactgttctgttatttattaac
attttaatttatagaattatagacttaacagcaaaaattcaaacactgagggtcatcggtgaaaata
65 2864793 — NO gcctattggcttcaagttgtttacgctttggtaggttttggcttgttccctcaaaggatcccttcttcatgtcctcccatgatgttgcaggcaagggtctcttgttatat
gtggtactaactcgggcccacctggtcataatttc
66 2976430 — NO gctcctacagtaacactcaatcaattcaccccactccagtgttcttcctgcaacatcactgatttagatggcccactctg
67 3862771 — NO gggaatctattaatagtggaggaagtatttagtgggtggga
68 3192159 BAT2L NO tggatatatggcattgacccgcttgctttgatacgaaacaaaaaagcagacgactccttcatcccatctgctcctaccgtgactgtgga
69 3062031 — NO gggtttgtcatgctacgctgtgccattcatgtgtttttttgctcatgctgttccttgtgcctggaaattctccccctaattcccctgagcagtggatgcagtggatac
cctccccagatcccccccaacttccctgagtgttggctaccaaaagctctgagtgcacccagggagctaagtcctcctgcccacaggcaataatggactga
cacggggtagacttaaagaaataagaggcacatcaatcaattgaaatgtgtgggaccttacctggactctgaatta
70 2505555 PTPN18 YES gagcagtacaggttcctgtaccacacggtggctcagatgttctgctccacactccagaatgc
71 2361309 — NO gagccggacttccttgtcccaccag
72 3569829 — NO gtactcgcctcctgcatggagcacgctcaggggtgg
73 2946327 — NO ttactgttgctgtccgtaaactggaacctctgttcactcaag
74 2751432 — NO ggaactcctcagaacttataatatgttgatattctttgattcccagatgaggggatgggtaataggatacatggttttccagacttgtttgaaaatgcaactattttt
gggttgcagggaaggatatagtagaactcatgggaactggtgtttcttggaacatgctttggaaatgctgggttatgccctgttaactcttacatcattagttttta
gcccaaaaggaaacagcaaataatgttttatatgagccacattttgcgttgattttcc
75 3907608 ZNF335 YES ggacgtctacggaagtggagcacctccaccaagagccaagaggaagagggaccagaggaggaggacgatgatgacattgtagacgctggagccattg
atgacctgga
76 2316543 — NO atgagacctcagacaaagccaccagga
77 2453070 C1orf116 NO tgcgaccagtacagaccctgtcctggctgaacaagaagagacacatgctccacttgggagcctttgccaccacgcaactcagggctcaagatgaatggga
gggagagatttgagtccaagcatacatttatattcagtgttgtgccattgagttcccatgtggatcattctgaaggtgatctccacaagagggtgtgtgtgtgtgt
gtttggtgtgtgtgtggagggggggccgctggatacatcactgaagctattgatataacacaatgagtcactgttcagaattttgctcttgttagatgttttcttac
attgggtagagtccagcc
78 3119603 RHPN1 NO tccagctggcagcaagcaccgagcatgccctccccacccagaggacctccgggcaatgcctgtcccgcctcatgctggaggctgcctcgggcacctgcc
tgcccattaaagactggtcagacctgt
79 3908801 STAU1 YES cactgcagaaggaacgggcaccaacaagaaggtggccaagcgcaatgcagccgagaacatgctggagatccttggtttcaaagtcccgcaggcgcag
cccaccaaacccgcactcaagtcagagga
80 2525664 — NO gaagctgttttaatggaggccgagagttggacaattttgtgttatggagaattctgggaagaaggaaagacccggatgggactgtttattaaggcttatgactg
gactggagata
81 2395926 CLSTN1 YES tacgggaaagaacatcaatataagctgaccgtcactgcctatgactgtgggaagaaaagagccacagaagatgttttggtgaagatcagcattaagcccac
ctgca
82 2571145 ANAPC1 YES ctcaaaagtgtttattacatctgacctatgtgggcaaaagttcctgtgctttttagtagagtcccagctcca
83 2836006 — NO ggatgtacactgatttggccctttaaatgacattataccaagaagttggtataagggagtaggagatgagaaaactttttgaaaaatcatttggtgcatgctaag
gtagcttgtaggacatgtggttttaaaaaattcatggattttgaagaaggatagggtggaagtaaaatttagctgatagcatagggatcatttgtgatttatataga
aaataattatatttttgagtgagaagcatcagacttaaatttttttcttctattttggttattaccaaaaggaacagagaaactctcagaattctttgaatcatagaatg
ttagtgctggaaaggactaggaagtgacttgtacaaccccttcattttacaaaggatcagagagaattggttagtagagtcccaaatctgcttttagaagtaata
tggtgatcatcagtttagattcactgtaggaagggcagccctgttaaagtttgtcaggagaaaaagggaaggtatcactttttgtatgttcacccagttgcttctg
tagttttcatacccctgttttctcaattttcttagaactgtctttaatggcccagctctaccagggcttgttgtctaaggacattaacttgtgctcccctcagggatgg
gtttactactagctgtcagaaagctattgggtatcctaatgtgttaatagctgaaactcagctgtaatttctcctaaatacttcagcattttgcattctgtacattgtgg
tgctttttccaccttgtattgttgtaactgtaagctcctagggggcagcaatttggtcttaggcgtgtaccctgtttagtgcctggcaatgccatgtttatatcaagg
tcttaatattacttttgagttatttctcccactcttcatggaagtgatgctccagccttgctaaaacactgagggtcctcccgataagccaggcattgtgattccttg
gcttcaagtgccttctgtcttccccgaaggtccactgagatctacaatcccccctt
84 2517773 — NO tagcggagaatgacctacctacttgattaatgatgtctgcatgggcttactaagagggtgtggggaatggtggcaggggtaactatcatcgagaatataggg
caatgggtatattctaactttgcataactttgctagattatatatatctttactcacaataagcaaagttgaacaacttaaaattgattccctgttttctgttttcactatc
caactaggatgaactcttaagttcatacatatactttaaaatgggaacaaacatagcctgtcatgtctttatttaggctaagtgcatatgtatgtataagtaatgtgt
atatccttcacttattaatagtgccttcatgaattcaaagacccttgtcacatggtgctcaggaaaaaaaaagtgccaatattctttttttttttttctctaagaagtact
agtttaggtaagtgaaattcaatagcatatcagtgctttaccttagtcactttttgtgttttgatcacccttagtcatcactggagagaagagtttgaattcatttgtgg
ttttgctttagtggcaaacctccttacagggatgagttgccctccattctccttgccatatttggttaatctaggccatgacctttgaggggaaaaggcacagatt
gcaacttttctttcctgcttttgtgaatcaggccatgttcacgcagggtccttgaaggtgacttgagtgaggaagctatataccgatgacttaccaatttttggtctt
ataacattctctctctttttttttttttttttttgtagcatatggcttcctctactgtatgttggcatttgccacttttggggatttgactcctgcaggtattttt
ttttttttcttttgggggagtgtgacggcagtggatatagtcttagatgatgtttttaatagttcaagtccattagtgtcttactctagagaaaacg
aaagactcactgtgtgagttttcttgccctctggttttcagaattctgtgtagtttctcaacat
85 3064957 — NO aaatccacagccacatctttgaatg
86 3239181 KIAA1217 YES tcattctcaccgcagagtcaaaatggccgagcaccccctc
87 3629017 CSNK1G1 NO tcaccatctataaggtctcagagcagaggattattcatggtaataagtgggggtgtggtgcagccattccagtaacaccca
88 3709453 — NO ggtgggacttacaggtctcgctatagcaccagataaaatccatactacaccctatcattacctgggaatgagggtacaggagaaaacagtaaagcctcaaa
aggaggaaattcgtaaagagtccttaaaaaccttaaatgatttccaaaaattattaggggacgttaattggataagacctactttaggaattcccacctaagcaa
tgtctaaactgtttgctttgctgagatgggatccaaattcatgtagcaaaagaactctgatgcctgctgcagctgaagagttacaaatgattgaggaaaaaattc
aaagtgctcaagtccgtagaagagatcctagtgttccattacagctcttagtgttccctactctccattctcctataggagtgattgttcaaaatgttgacttagtta
aattgtcctttttaacgcacagtacgactagaactttctcaatttatttagatcaaatagctattcttataggccaaatacaactgagaatagtcagactcattggca
ccgatcgagataaaaatgtagttcctttaaacaaagcacaggttcgacaagcctttattaattcgtcagaatggcagtcaaatctggctgattttgttggcagtat
agatattcattaccctaaaactaaaatgtttcagttcctaaaaattgactacctaaattttacccaaaataactagttccattcctttggagggagccgtaactatctt
ta
89 2732012 FAM47E YES ccttataagccaaagtgggtgaagatgaggtatggagcatggtatttgaaccccaagttgtggaaaaagcaaagagtagacgagcctctggttgaccctga
ggtctcacata
90 2787588 — NO ggttgctgcccttgagcattttgcc
91 3630110 — YES atggagcacctgttcgtgtacctcc
92 3738711 — NO gtagctaaacatatgcgtggggataaaaatcgggtggacaaggccagatacatgaagacatgctccactctcatctgtgaa
93 3675240 — NO cccggactgatgtgatttctttgacaattacaaaaaacaaaaaacaaacaaacaaaaaaacgcaaagcaatagcagggaaaggacagtttgagaagacct
gcaaggcctgccaggcggctcgcttgtgcagacacaaccgggacggctttgaggggacgtgcacacccaag
94 3458922 CTDSP2 YES gggacctgagaaagaccctcatcctgg
95 2694337 — NO gaggaagacttgtgcgcccggcccacacgaaccatagagccgatctccggg
96 2990414 — NO ccctccacacgtgttcagttaaagtgtgaggaataccctccccagacaaacatcacagatttccgaaatcaaacacgctccagcaagtgttctgcacacccc
actg
97 3190328 — NO cttctcagttgggtcaagtccattgacctttctgttacagcttgagttttgtgtcttacgtagaaaaggtgcccctgctctcactttctgcacagctatcaggtccag
ctcatagcagttcttcta
98 3745435 MYH3 YES ctgagattgcaggatctggtggataaactgcaagtgaaagtcaagtcctacaagaggcaggcgga
99 3110076 LOC100134128 NO gtaaaagcgcggcaccgacaccagctgtgtgcagcagtggcggcggcggccgaaggagaaatagaacagcgcaggcaaaagaagaaaggcgcgg
gctgg
100 3471539 — NO cacgggtccgctagctttaagtacaacaggatttccgtgttcaaaagactatactaagtgcttaatcaaatcccgtcacactaaagccaaatttagttctctagg
aatcggagtctgcgtata
101 3918710 SON YES cagagcagcctgtagacgtaccatcggagattgcagattcatccatgacaagaccgcaggagttgccggagctgcctaagaccacagcgttggagctgc
aggagtcgtcggtggcctcagcgatggagttgccggggccacctgcgacctccatgccggagttgcaggggccccctgtgactccagtgctggagttac
ctgggccctctgctaccccggtgccagagttgccagggcccctttctaccccagtgcctgagttgccagggccccctgcgacagcagtgcctgagttgcca
gggccctctgtgacaccagtgccacagttgtcgcaggaattgccagggcttccagcaccatccatggggttggagccaccacaggaggtaccagagcca
cctgtgatggcacaggagttgccagggctgcctttggtgacagcagcagtagagttgccagagcagcctgcggtaacagtagcaatggagttgaccgaac
aacctgtgacgacgacagagttggagcagcctgtggggatgacaacggtggaacatcctgggcatcctgaggtgacaacggcaacagggttgctgggg
cagcctgaggcaacgatggtgctggagttgccaggacagccagtggcaacgacagcgctggagttgccggggcagccttcggtgactggggtgccag
agttgccagggctgccttcggcaactagggcactggagttgtcggggcagcctgtggcaactggggcactagagttgcctgggccgctcatggcagctg
gggcactggagttctcggggcagtctggggcagctggagcactggagcttttggggcagcctctggcaacaggggtgctggagttgccagggcagcct
ggggcgccagagttgcctgggcagcctgtggcaactgtggcgctggagatctctgttcagtctgtggtgacaacatc
102 2792431 TMEM192 YES tccttggatatcacccagagtattgaagacgacccacttctggatgcccagcttctcccacaccactcattacaagctcactttagaccccgattccatcctctt
cctacagtcatcatagtgaatcttc
103 3828963 DPY19L3 YES gaagtggagcgagaaatctcattcagaacagagtgtggcctgtattactcctactacaagcagatgctgcaggctccaaccctcgtgcaa
104 3874927 CDS2 YES gttcattgtccccatatcttgtgtgatctgtaatgacatcatggcctatatgtttggctttttctttggtcggaccccactcatc
105 3012468 AKAP9 YES ctggggtcagggaatttatcttacacacagtcagggatttgacatagcatcagaaggccgaggag
106 3541309 PLEKHH1 YES gatgtcatccggaaacctcaaggccaagtggatctgaactcccgctgccaaattgttcgaggggagggttcacagacgtttcag
107 3543492 PSEN1 YES gcaagtgacaacagcctttgcggtccttagacagcttggcctggag
108 3878896 — NO aacgtgctcagggagaatcagctggtttct
109 2669445 — NO atggctaaaactccaatagacagcatgtagtgcttgggtgacagactttgggacaatcacagccactacaaagtgaaaggggagaatccagaaagtacag
agccagaaagggagagccccaaattctatgtaaaaactgcccaaatctttggctgaccactgaactatgcatgcatggggcagacgctaagcaacctagct
aaggataaaataactaagccgagaattgaggtagtgcctc
110 3953763 PI4KA YES gagcaacctggacataactgtcggctctcggcaacaagccacccaaggctggatcaacacataccccctgtccagcggcatgtccaccatct
111 3529048 — NO gcccagtacctctccaagggttgtatatccggtgggggtggagggatcggcagaggtggtgtctcagccctttcgttcaaggagcgggttgatggtggtgg
tgtaggaattgctgggtcttggaaactaggggcaccaggtactgcgttgtcccgaaaccactttagttgcccatgcttcaaggcatagcgtgtgtcaccaaac
cactgaatgatctcaggccgaggtaaaccagtgatctgttctaacttttggtaatcctcacgccgtgcccactggcactgtaaaaaaaaggatttaaggatagc
cagctgctctttggttttgcgcttggtctttcgctggcgttgcatatctggggaaaggtactctgtggggccaactctacctggtactga
112 3691111 — NO ttgacgtggcttatcaacctttgtctcttacgtgctctttgttccggccatcgtcttgtttaacaaa
113 3845902 TIMM13 NO gggtccgcatgtacgtactgcctgcccggggcttaggagggtggcaccggtgctgggacacacgggactgtgtcctcgccaccccccgccctgccccct
gccagccagtgcagcttggatctcgggggtgtggggccctgtgccttcctgaagtgctggcagcccagtggcacctccttcaggcctttggggtattcccct
agtgtgcccaagtcagcctcatattctgggcggacagcttgtctggacttcggagttgggggtggtcagacaccacaggagctgtcacctcctgcggatgg
gcaaataaatt
114 4009521 PHF8 YES gaccctgctttgaaatctcgacccaagaaaaagaagaattcagatgatgctccatggagtcc
115 3817782 — NO catgcccggcccagtaattaggtttttttttaaaaagccccaaaccttaattttatttgcccctcatttcacggagctcccagcgtagtggggagaagctggccc
agagaaccccacgtcctgcacagtgagggccagcccttggggaccccatgtcctgcacggcgggggccaggccctggggccacgtgtgttcccccccc
acccctattttctgccgcgtgctcgttctgctgcacgtggctgtcacttgaatgggaatttaaaaatataacttaatgcacactgacttcccttgattggtgcaatta
attatttgaaaagaaaaatatcacagtgttcttaaggactggcatttttccaagctgtgtcagttttgattgatgtctgacgccgtggctggcttctgaaagcctca
ccagttctgatggcttattggcgacttcagtgtatccagcaatctctgctcatctttctgggggaatatataatgatcagcaggcctgagaactcctacaaatca
gagataagaaaacaaatggcccgatgaattcggcgtgaggggcttgagcagacgcgttacgaaggagctgcaggaacgaaagccatggttcagtgccc
agcatcggtagaagtcagaggcagccagctgggagacaccgccagccccaggacggccacgtcagaacaccgccaccagatgccagtgaggaggg
cgcagctgcacgctgctcccagccggggtggatgcagggcggtgccatggccatggaaaaccgttcggcattttcttggaaacggaagcatgtaccctgt
gccccagcgatgccactctgtgcatatttactcaggagaaatgaaaacatatgtctccagaaagattggtacataagtgttcttagcagttttcttcacgagagc
cccaaactggaaacagcccgcacgtccatcaacaggaggatagataaataaataaccatagatccacgcgcaaccgagtactgtttagaaatgaaaagga
gcg
116 3948736 — NO cgttgatcccacctccttgatctggtttctaagacctcatacaaactgggcccgttagtctttgctccctgatactatctgataccatctggtctcac
117 3104724 ZBTB10 NO ctggtcggacggaaacgctccgccggctttattgtcgcttcgttatgtggcggagccgagcagtttagcgtgcctctcaccctcagcgcctgcgaagccggc
118 3364565 PLEKHA7 NO actggcctgtgctacttattaccgggcttgtaatagcggttcttgtctccatagcctgttgagtgttcccagatgtgactcacctttctgctgccctatcatgcag
gcctactga
119 3540221 — NO atgaggccggaaagatggcgaatttgcagggctgg
120 3458075 — NO ccaaattttagttgtgaggaaacagacataccaagtattctttttagcaatgagcattagttctgtttttcttaacagtgaggcaaactatgtatatttacattttgtag
aatatttcctccaaaattggtttctgcatactttttgtttttgctatcactgtttgggcttagagtagtatccttgaggctcgtctcatcttttttatttgttttgtttttttgttt
gtttggttttgttctttgagactgctgcagtacaatggagcgatcccggc
121 3773290 — NO caggctcatcattccttgttggatttcttcctggacttatttaaaagttgttatagctattatgaatgagcttttttaaaaattgtaattcctaactatattactggtgtag
aagaaaactacagagctggtatccagctactttattgatttcttactgtttctattggcttttatttttcattagtagaggttgagaatttcagtatttcattcccagatcc
atatctcatttctttctcttgttttctttgcgttgctggagcctccaaaacagtctggggtaactgctatgctagcaggcctcctcatc
122 2835195 FLJ41603 NO ttatcggtgtagcagagaggttcccaagactcttgactggtcctgggagtgggtgtgaccaagtcatagttctggaatgtgtgtaggcaaattcagaggctgtt
ccagggaagaggggattttgatactgtgttaggtggggtgtgtgaggctgttggcagcaggtgaacagctactgctgtgttctcaggactagggaacaaag
gggtatgcaaatcatagaggaaactctgggaaggcggtgataaggcctggtgggtggggaggttagggaatggcttgctttcctgtttctggttagaaggg
gagccagggggaacccccagtggtttcaggtggcccctgaggtcctggaggcagccgtggatgtgatgcaattggctgtgggaccttagatgtaggaca
caacttcagtgttcccatccagaaagacctcactcacagggttgtgctgagaatgacgtggggctaagcatgcagagctccctgtaaactgtgaagtgtgat
acaaatgtaaatgacagcagtgatctcggggtggcccccggcatgctgccctcccccacgcccatgcctgtggcagcaaaccttgttcatcagtatagcttt
ctttcctgtaacccaggatctaccttggggggcttctcaatactgcattctatgtagccagcctctttaacttggtaagtgagccaccccattctagaacctggaa
attggagcccctcaaaaacagttcctgttcaaggaggactgacctgctggggcaatgttgggtgcagtgcagtccctgcttggggtggtcatgtctaggctgt
tgctctgggcaaagataagagcaagattcacagaaatgggaaaatgtgaccaagtgtgatcttaacaactgacaaagtttgtaaccaacccaagttagaatg
tgtgtcaaacaggaggtagtttagatatgcttccaagaacatgtctgtgttataaccatagtgcctaagcagtgagctctggtttttgaagggcttttaagaa
123 2988321 FOXK1 NO aggctctccgggcaaatcagaaggccacgagagagagaggagcggggagagtggtgaggaggattcgtctctgactgatgaacctcgccgtgcctgtc
tgtcacatccaagtctgtgccagctgctgggaggtcagactcctgccctgagaa
124 3632941 UBL7 NO cccagcaagttgcagaggctactgcccttgggaggcactcatgaaggtgcctccatctctccatccccaatatacctgatggtcaactctc
125 3855574 — NO ggcagcaggggtcagattttcctcatggcctctccagcaggccagcccgggtttctcctggtggctgggagccaggagagcggctcccatgcagagtgct
ggtttcacatttgtgggtggcccatccgttgaggccagtcacgtggccaggcccaggaccagatgggagaggaccgcacaagtgcagcgtgagctgtgg
gaggtgtggctgaccacgcttagagagtgtggtgccaggaaagatctgatgtgtcaccattctatatctgtgatgggcagacgcaggcaggtcaaagggg
ccctggggacttaccgagcccctgcctattggccaggcactgtgattgtcctcggtgccatgtgccatggaagccctctcagaggtcgaggggaggcagg
tggagacagagcctctgtaggcctttcaagctgtagccccagagcccagaggcagccgaattcatgtgtgcagtcagagagcacttagtgggcactgtagt
caatcagtgagcgcttactggacaccacaggcagcaagcatttactgagtacctctggcagttgatgcatacttcctgagtacctgttcatagcaggcttagct
ctggatgtggggtggtgaggaatcccacaggctgaggggtggcctgggagctttccagggggcctgaagcaggaggggctgcctgagtgggtcagca
gcccagcccagtgccctacgcagccctgcccacacccccaacccagcctctgtctccccagtcccatcccccacaccctggtccctcctactttgtgcctcg
aggacactgccccgctgccctcctcacttcccagcgtctgctgtcccctccgctgctgctgcccggcaggattgctctgtgtctcatccacgtttgtccctgca
gagttcctcgcctctccctggaaccgccagcctcatgccgcatctcagaggctttttttttctctcttttttttttttttgagatggagtctcactctgtcacccaggct
agagtgc
126 2648215 — NO tttcgcagttgccaaaaatggtgccgtaaggctttcctggaattaagtagtcagaggtatttggttagcagatgctttgtaaaacctaatatattcccactatatttc
ctttaaaaatcaagggggggttaacacctttagattgtcatgttttattgagaaaaatccacttctctgaaactccctattactg
127 2714009 — NO atctgaggccaaggataaattcatcaactgggtagccaccactatagaagaagccaaccacaatcaatgtcggctatgcgtccagctgccagaggccgcc
aggaatgagctaccttgaagaatcgtccgtgacaacatttctgaatggctatgtcactatcaatggggccacaacaacaacacttgcaatccaacctgaactt
cctatgaccaaaccaagcaatctatttatgcccaagtcaagtgaaaggtgaactccaccttcaccatgcatcaaaagccttggtatcctgcccaatatgcctgg
aacggtatatattgggaacctgctgtgctggtggccggattccatatagctcc
128 3342827 — NO gagcaggcagttggcaaaccggaaag
129 3494235 LMO7 YES ggaaagaagccgcaggatcagcttgttattgagaga
130 3816344 SF3A2 YES ggagctacctggcacatacgcaggggaagaagc
131 2340361 DNAJC6 NO cggcggcttcgcctcgcccggcgaagcttctctccggtggccgctccttcttttccctcctctttgcgtcatgtcgggcacttaatttttt
132 3557286 HOMEZ YES agagcagctggctatccttaaatccttttttttacagtgccagtgggcacggcgtgaggattaccaaaagttagaacagatcactggtttacctcggcctgaga
tcattcagtggtttggtgacacacgctatgccttgaagcatgggcaactaaagtggtttcgggacaacgcagtacctg
133 3911399 — NO attttcctgcattcacgatggcctcc
134 2612381 EAF1 YES cagcagtaaaatccaggcccgaatggaacagcagcccactcgtcctccacagacgtcacagccaccaccacctccaccacctatgccattcagagctcca
acgaagcctccagttggacccaaaacttctcccttgaaagataacccctcacctgaacctcagttggatgacatcaaa
135 3354739 — NO tttgagaggttatttgtccatgggatgctcgtgttaaaacaaaaa
136 3434425 RNF10 YES taatcgcaaacgtgaactttcctaccccaaaaatgaaagttttaacaaccagtcccgtcgctccagttcacagaaaagcaagacttttaacaagatgcctcctc
aaaggggcggcggcagcagcaaactctttagctcttc
137 3734620 KCTD2 YES aggaagcggagttttacaacatcgcgtcccttgtgcggctggttaaggaaaggatacg
138 3802333 LOC728606 NO ttcagctacgttgtcccagcacttcactggttaaccttttatgtccaccatttgtggatttcacagctacttgtcaatggtgaatattgatcatcatcattatctactga
gctgctaccatatcccagctactccttgcatgttgttcattattttctcaacactcagcatatttgcaatatgttatgtaatatcacagacaaggaaactgaacgca
gaaatgttttatttcttgccaaacatcacatgaggatgaacaatgaaaccgatttgaaaccaggattgtctgattccaacatctctgggtctttttcactctgatatg
139 2896736 — NO aggatctagctctcttgctcaagctggagtgcagtggtatgatcaaaactcactacagcctgcaactagtgatcctcctgcctcagctatagctaaaactatag
140 3053930 — NO ttggcacactaactccacttctagacatctatcctaagataataatcaacatataaaaatgcacatacaaatattgactataagaataaaaaaatttcagcatttaa
gctgtacaggtgaatgtttaaattatggtacacccatttgtgttatttattttaaaaaatttttttgaagtataactatgtagaaaactgtcctagcataatgttaagcat
cgttcccaatgtgttt
141 3459700 — NO ctaaggtgagacaggtctgtgaatccggggtctctgtcacttggggaaaaaaaacgggcagaaaagctctgaagtttgaaacacataaggaaaatctgcta
tctgtacccccaccctcccaaaatatagttgacgcccccgcgtgatgaagagtttatgggggtggaggcttggaggagatgtcactgcgcctgggagcttgt
gtccgattccgggaggtggccgtgtccgagtgcgtggttgtacatttccgaaggtctcagtttctctcactttcagcccgcga
142 3223562 MEGF9 YES gtctgccagttgcgatgccctcacag
143 3888086 ARFGEF2 YES ggaaaggccttgacatggcaagacggtgtagtgtgacgtccatggagtccacagtgtcctcggggacccagacaactgttcaggatgaccctgagcaattt
gaggtcatcaa
144 3378887 TMEM134 YES ggattccagccgaacttccatccgcag
145 3280240 — NO acctttccctgaggttggataggcactgctccccttctctgtgcccctggctcccacatctaatgactcctggcacttacgacactctcattcaaattttctagcc
atgcaccttaagccc
146 3379391 — NO ttttgtacatgcacttgcagtattgaggttaatca
147 2351210 FAM40A YES gcagcacccacctcaaaagccaaaacagactcaatcaacatcctagcggacgtcttgcctgaggagat
148 3758440 — NO gtttcactatcgagagtcggactgcttttggatttacgtggctttgtgggatgcggtatgaagatcgttgcattcaagtttaccgcctctacttcactgcagaatct
gactgccgtcagatctgtatgac
149 2617213 ITGA9 YES tattgggctggaaccatcaaagtgctgaaccttacggacaacacctatttaaaactgaacgacgaagtgatcatgaacaggcggtacacc
150 3677835 CREBBP YES aaccagaggagttacgccaggccctcatgccaaccctagaagcactgtatcgacaggacccagagtcattacctttccggcagcctgtagatcc
151 2332491 — NO atccactaagaggcgcaagttggctgcctttccagaatcctctgattttcgttgatccaaggggctggaactgagcttcctttttcatgccaagtagggtccaaa
caacagagaaacataaagctcttcctttctccccaacctcaccagcccttaccatggctggcttcccagtgattcattcaaggcaaca
152 2932426 RBM16 YES tggggtccggccatctaatgtttccagtagttctgggattattgcagcccaaccaccaaatattctaaataactctggaatattgggaatacagccacccagtgt
gtcaaatagttctggacttttgggagtgctacccccaaatatacctaacaattctggacttgtaggagtacagccaccaaatgttccaaatactcctggacttct
gggaacacagccaccagctggacctcaaaacttaccccctttaagtatccctaatcaaaggatgcccacaatgccaatgttagacattcgtccgggactaat
accacaggcacctgggccaagattccctttaatacagcctggaattccaccccaacggggaatcccacccccatcggtacttgattcagctcttcatccacc
accccgtggaccttttcctccaggagatatttttagtcaaccagaaagaccttttttagctcctggaagacaaagcgtagacaatgttactaacccagaaaaaa
ggataccacttgggaatgataacattcaacaggaaggagatagagattaccggtttcctcctatagaaaccagggaaagcattagtagacctccccctgtgg
atgttagagatgtggttgggcggcctatagatccaagagaaggtcctggacggcctccactagatggtagggatcattttggaagacctcctgtagatataa
gagagaatcttgtgaggccaggtatagatcatcttggtcgaagagaccactttggctttaatccagagaagccctgggggcatagaggagattttgatgaga
gagagcatcgggttctaccggtctatggtggtccaaaa
153 3273785 ADARB2 YES taaagtaagcatattgtcaaccttcctcgctcattcaagcacctgagtcctggcatcacaaacacggaggatgacgacaccct
154 4015409 TSPAN6 YES tgagaaggctttgaagcagtataactctacaggagattatagaagccatgcagtagacaagatccaaaa
155 2428715 PHTF1 YES ggccacagcgttcagttgatgtggttgtatcctcggttttcctactgacactttcgattgctt
156 3261500 NOLC1 YES gtctgccaaggtcccagagcgaaagttacag
157 3144008 NBN YES cagacttttgactggcgttgagtacgttgttggaaggaaaaactgtgccattctgattgaaaatgatcagtcgatcagccgaaatcatg
158 3527425 PARP2 YES atctgtgaaggccttgctgttaaagggcaaagctcctgtggacccagagtgtacagccaaggtg
159 3836942 — NO taccaggagcccatggatggcgtgacccagcaggcagcacagaatgtacttgccaaggcgggcaaagagtaaacc
160 2746889 — NO ggagtcaaacgtcagagcctgagacctttgatgaagggtcacatcgccagagctcagtgg
161 2853401 — NO gctgagagctagctttgctttataattttgtacttactaaaaaattaaataacttataaatggaggaaaacttggatcagttgatagattttgggggagttagtgaaa
tttcttgaggggattttcaatcgaatgcttttattttctgtggcagtaatgatctggttggtttatctcataaataactgatgctgctgctttttgtgttctttgatgtctca
ccttatgtttttactaagtaaggacagcaatggattggcactgatgc
162 3593678 USP8 YES tgtcctgcgcaatgagcctttggttttagagggaggctatgaaaactggctcctttgttatccc
163 2466363 — NO tgataattggtgacgacaaggaaattaagacgattgctcaaagagatgca
164 2961018 — NO gatcttccacacaaagatcaggtgaagaaatctatgcagctatacatgctaggacctgagtacaccatccctgcaa
165 3307825 — NO ctgaggaatcttaaatctgggtataaacgtgaaatggttttattttttccttactgggtctccagtcatacagtgtaaaacactcctaacctctgtactttcctctgca
gtgcagtcctttaagaatcccttggtccgatgtaactttgccgccact
166 3375666 FTH1 NO gacccgcagggccagacgttcttcgccgagagtcgt
167 3510380 C13orf23 YES gcagctgccaccgtttctggaatgaacctgctgaatactgtccttcctgtgttcccagggcaggtctcctcagccgttcacacacctcagccatcaataccaaa
cccaacagttatcagaaccccttcattgcccactgcacctgttacatccatccacagtacaaccaccactcctgttccttccattttttctggcctagtgtcactgc
caggtccttctgccactcctaccgcagccactcctaccccaggacctacaccacggtccactcttggttccagtgaagcatttgcttctacttctgcacctttca
ctagcctccccttttccaccagctcttctgctgcttctaccagcaacccaaattctgcttcattgtcatcagtttttgcagggctccctttgcccttaccaccaacat
cccaaggcctatccaacccgactcctgtaattgctggtggctctactcccagcgttgccggtccacttggtgtgaacagtcctcttttgtctgcgttaaaaggttt
tctgacatccaatgacaccaatttaatcaactcctctgctttatcctctgctgtcacaagtgggctggcttca
168 4026959 HCFC1 YES caagccagccaacaagcggcccatgtcctc
169 2888352 RNF44 YES agagcagctcccgtcgtaccgctttaacccggacagccatcagtcggagcagacgct
170 3320634 USP47 YES gagaaattgagcgcaatacatgcaag
171 3752442 — NO taggtgcatgacactgctcagtttgatgtgctaatctgattccagtaaagagaattgctgatttaatgttgaggcccgatcttccacaggtcctaaatgtttcccaa
aatacatggatagcatacgactgggtttttttaaaattatcccaggtcaagcatgagtatctc
172 3188731 NEK6 YES caggactgtgtcaaggagatcggcctcttgaag
173 3303115 — NO ctggaccaaccactacttccgtgtttcaagttcatttttagcacatgaacatgatcactgttagccagtgaagtagcttctgactagatcattgattagatctcaca
aaaaaccaaaaatagtatatggaaaccaagatgagagcaaaagaaaacgttacctgagtaggcagctaaaacatattttgacattatttttaagcagcattcat
aaggttcacgga
174 3820685 ILF3 YES ggttctggcatttatgacccttgtgaaaaagaagccactgatgctattgggcatctagacagacagcaacgggaagatatcacacaga
175 3882554 — NO ataatgggatggcaaatagtctccccagcccagagttcaatatcctcctggttgctggctgagcttagactagaattatgttgagtttccaggacacccatttta
cgaatgttattttgaattgcctgttgtatgtgataata
176 3054154 — NO ctacacgctgccgaggaaaacgcaacagacatggcaggtgcctcacgacaagaaacacttacaaatagaatcaaaactgattcaagtcataca
177 2624472 CACNA1D YES atccgcgtaggctgccacaagctcatcaaccaccacatcttcaccaacctcatccttgtcttcatcatgctgagcagcgctgccctggccgcagaggacccc
atccgcagccactccttccggaacacg
178 3652530 POLR3E YES gactgctgtgtaagctatggtggcatgtggtaccttaaagggacagtacagtcttga
179 3980537 ARR3 YES actaccacggagaacccatctctgtcaatgt
180 2808239 — NO cacaggtgaattgtctgggaagtcaggatgttgcacagaagctatgcaagtcatagattagaaaagcaagaatccacattcatgctttccagcatagatgag
gagatactttttctccaccttcttagattcagtggctgggcagagagtgctgtgaattcatctgacaacaggcagattaacacgagaaaaggaatataagtttttt
attttttatttttttatttttttgttttgagacagagtgtcactctgtctcccaggctggagtgcagtggctcactgcaagctcccacctcccgggttcacaccattctc
ctgcctcagcctcccaagtagctcagactacaggcgcccgccaccatgtccagctaattttttttattttttagcagagacagggtttcacctcccaaagtgctg
ggattacaggcattagccaccgcgcccagccaagttttttaatgtttaatctaatgtgcatggaggcatcatagaaagaactgaatatccaaaagtgtggtgaa
atttgagactttagataccatcttaatgatagtggcaggaggcagacaaatcctagggagacaagggtgggtccctggtgaaaccccaccttcaaaccaaa
gacagatttaagcatgaaagccaagctacaagtctccagtaaatccatggaccggattaagaatctctc
181 2811059 — NO ccatcagcttgtgactcatggcttagctggtctcaatggggaacaaaccagagagtctatggatcaacacaaagctataactgc
182 2858392 — NO ggcccagcttcatggatatacaaactatacattcacatgggttccacacctagatgggctcttacatcatgtagctggtcctacctgggagagagc
183 2779739 — NO tctgttcacggagcttagttctacttcctga
184 3298972 — NO gttaactataggtaggggacagagaaaggagcagagttaatgtatgctattgaagctgagttgctatcagtctgaactagactttgaactcagcatg
185 2933580 TULP4 YES gaaactggccacgtgcgatgcggacggaggcatattcgtgtggattcagtacgagggcaggtggtctgtggagctggtcaacgaccgcg
186 3528128 TOX4 YES caactaggccaaaccagtacagctactatcc
187 3528025 — NO cggcgctacgttaacttcgactatattaatgagcatcacgatcttcattttcatgatcccgtagtcctcgcggtcgtagaaaatgaaaggaaagcagccgttaa
cacaggaagagcgaaaaaaggacattttccctggcgatcgtggc
188 3581134 AKT1 YES gatgatctctccacggtagcacttgaccttttcgacgcttaacctttccgctgtcgccccaggccctccctgactccctgtgggggtggccatccctgggccc
ctccacgcctcctggccagacgctgccgctgccgctgcaccacggcgttttttta
189 3676391 — NO tgggccatctcctcggtacaggtcagctgccgccggcggagctcctcatctgtctcct
190 2319003 — NO ccaagagcccggaattttcattacaactttcaaagagagcaagaggaggagggaaaaagatttcacaaaagcattatcaaggccccaacccaggatgccc
tgctgtacaaccaaaatttgtaagaggtcagcctttcagggagtcaaaaacccagcatgtgga
191 2858313 — NO ctgcagagcaaaatatagaggcactaattttgttatatttgcagcccacatactgtaataccagatttgctcctgttgttct
192 3048750 — NO cgggaaacttcggaagacagctgtgcctggctctgtggctgcatgcagtgcttcacttggccagcagaggtcagctgtgccgagctgccccagccatgag
aagagaagcctgcccttgctggcaggtggctatggccggcccagagccttcctgcccagctcctgcagccctgctgcctgggatcaggctgggagatgg
gccttcctgaccgccagccttcctctccccgagcacacgcacatgtagattcggggggaagctgcctgctcttccttagaggagccggggcagctatctgc
tggtccctttctgaacaactgttga
193 3360848 APBB1 YES tgaggaggggacgttgaccttccca
194 3387192 CWC15 NO gccaagagtggtaatggcgtctgtatgatcttcggagcctgctgcatcggacctcggc
195 3893880 — NO actccgcagggctggcacttcctgagggagtgggggctcaggcttcagacggactttattaaaatgtgtagtttgtgtgaatcatttcagtcaaaagtttcagct
atactcggccgttaagacaacttaatga
196 2393792 KIAA0562 NO ggaagggctgccatagttgccgcagt
197 2395248 RERE NO tcacagcagcgagcatccagggtttgcagggacgatgttacagactctgttttctgcctggcgtttcacttgtgtctgctcctagcctgtgctctgccagcagc
acagacatctgctccatcagacctcttccattttgcacagggagtgcaggaggtgaatgttcactttctgttctccagtgtcactgttctgtttccacgggatgga
aagcgcatgggcctgtgtccattgtagatttccttctagatttctgtgtacacacacttgattgttctggatgaatgtcttttttaatactccgaaaatttcatcatcta
agaaaatgattccatacaaataactcagcacacaagtgacccaggacatatgcctgccaaagggatgtgttagaaggctgccttctcatgcgcattgtcactt
ggatcttgtggtgaggacggccccatctttcttgccacagattgaggccacttttgagcaagggagatcctggagttaagacaggtgttgggggcagcctgt
attttaccctaggggcaggtctgcatggtgaccccacattgcactggtaaaccatttgagtcccactcttcatcctggaagtgggaactggagtcccacccac
agtgcattcagaaagcatgctgtgtgggggctgcttctcaggaggccaggcccttctgagcggaaccgtcctggagagagcctgccctcgtttccaggctg
cagccgtaacgcactttc
198 3403226 UNQ2963 NO ctcacccttgaggcccgggcacttc
199 3920956 — NO cccaaatgtgagttgcatcaaattcggtaaatgtagagtatgtttgttttctctgtacacaatactgacgtcagtgctagtgcctgcctaaactcagacaccagta
gatccttttccaga
200 3970256 REPS2 YES tttgaaaagtactatcaatgaagccttaccaaaggacgtgtctgaggatcca
201 2724115 — NO gcaggccttacttatttccacaggaccttataagctcatacactctattgcttattacgttactggaatctatctaagcagaaagaggctggcccaccttctgttat
ctatgtttctatactctttggacttgcta
202 3351955 MIZF YES caaccacatgcgctttcgtcacagtgaggaccggccctttaaatgtgactg
203 3133234 PLAT NO ggaattctgcttcactcgcttaacatatacacaacacctgtaacatacaaggcaatgggctaggtgctccagaccgggaaaaggagggacaggaatgcttg
gtctgatgggctaatatggcatttagagaagtaccaaggtacagtggagccggtcacaaaagggcagacttgt
204 2723089 — NO tttgtggctgttaataggaaggatgctggt
205 3102652 — NO tgtggcaaactaccacggcagatgtttacctatgtaacaaaactgtacatcctgcatgtgtacccctgaacttaaaaagttgaaaaaaaaaaaaaaagaaaca
aataggctgggcatggtggctcaatgcctgtaatcccagcactttgggaggccaaggtgggaggattgcttgaggtcaggagttcaagacctgatatagtg
agacc
206 3392531 — NO ttggacttgaatgactaggagaatgactactctaatgaacaaaaatgtaaatgttatatgtgggtttagtaagggaatgcaatgaacttggttttggatatgttaaa
cttgagttatcactggaacattcaggtagaaatgtttagaaagcagtttgaaataagagtttagtagaaaggttgagagcagcgctgcagatacagatttgaaa
gtcatctgcaaagagatgtgtcttagcgttctc
207 4015009 — NO tggaggcggccctacacctggcaatggaggt
208 2596170 INO80D YES gatgagttgccggatgacattgccaatgagatcactgacattccacatgacttggaattgaaccaggaggacttttcagatgtcctgccacggctacctgatg
acttacaaga
209 3591676 — NO aaaacctggaatgctgtaggacatgtacccactgaggcggatgcaaggagcgatggagaggaagga
210 3680412 — NO tttaccccttctcggtgacatttgc
211 3906169 CHD6 NO ctgcttgacttactgggtgatattgggctacaactgagactcactttgctcctgtgtaaagtggggcaacagcatctaccacggagggttgaagatttacgga
gatcatgctaagacagtttgttccaaactcaaaggaaatcatttgcaaacaacagaaaaggtcagaaaccgtatacctggccaagagagatcccttttacgct
ttgtttaatgtttcatgttgtattttgggttttcccatttactggattctgagctccaaaacaggaatcacattttatgttttcttattttaaaagcaataataataactagt
acttattgagtgcctactgcttaccatgttcaaggctttacatgattatcttgtttgttcctcacaaccactctgaagatgggctttgttattcccattttataggtgag
gaaaataaggctttaaagcattaaataatttccccaagattatccagctagtaagtgacaaagcaggaaaccaaaccaaggacctttttctctaggggctgaga
212 2803102 — NO ctatatgtagctaccctgtggcctccccctaaggtaaccactttactttttagtagtgaagaatgtctaaaatataataaaggtatatctagaacacaaacctcca
agcaggaacaacccattatctctcctttgcatgccctgtcaatggcttcaaggtcaaagctagctaagtctctgagtgtgtagggagctgacatcttggtgaaa
agtccttcagtacatgctagatcatagctgacttgcactatccttccaaactttggaatatctctctggtattggattggttacaatggaaacagaaagattctgat
catacaaaataaagattttcatttgtgagctcaaccattggatctgtcatcttccattagtagaaaaaatgaggaaatcaaatactttgttttgtttttaaccacgcag
agaaggaagagagtagagtgtgggaaattgatatatctgccttactgccccagcccctccctctggagtgtgcaagtggtcagaagtcagcaaattacttttc
catcatatttggccccaaactaccctggtgagtgaggagaaagggaatcatttgataaggtttggaaaatagcatctgtttttcttagtgtttctggatgaatttat
caggcatccggtaatttgtactttctgttgaaaactataatagaataccgtgcatagacatgaaaccttttggtattagtcagaagctacatactgactgctgttgg
agaagaccacatttacagtcaagggtagaatcatctgaaatagtttcccctggaaaaaaaaaaaacatggccatatatgcctacatagatctcctctttgcttca
tgaatttggaactaaacctgggtgtttagataattccagttctaggattttctcaccttgagtttattccccttattcttactagttcagtttggccactgtacatatgga
gcttactagaggcaaagcactctgtgaggggcaatggttataca
213 4025793 — NO ttgtgtctgctccaagtgcgaaccctccatgcactgcagagaacaccagaaggagaggagcactacctgagcttctccttccgggtctaaaggtggaacttg
ctttgcagcacccagcatttcactgtactgattcctttttttggatcaccacctcctgcgtttagcagcccatatgctgggctcactcagctatacactgcttg
214 2616236 FBXL2 YES aattttggaggctgcccgatgctcccatttgactgacgcaggttttacactttta
215 2959832 LOC100128757 NO tccggtgcttacctctaactgataaaactagctccaacccaccaccctccactgacttccttcgcactcagcccactcgcacccgggtgaataaacagccttt
gttgctcacacttagcctgttcaagttgtctcttcaattagatgctcgcataacatttggtgccgaaagcccgggataggggaactcctccggcagacctctcct
ctatcctcccggtacccacgttctcccatgcaagagacttccctcgccctcaggacctcagaccagctccgcgagcactccggcctctgtctatgga
216 3072195 — NO ttagtgtcgtcaggagactccctccatcagaattactcaggctgattgttttgagtcctgggacccagttggtatccagaatcttggcttgtttgcctaggaacc
217 3757471 ACLY YES gggtgtcaacgagctggcaaactatggggagtactcaggcgcccccagcgagcagcagacctatgactatgccaagactatcctctccctcatgacccga
gagaagca
218 3986531 — NO gagggaggaattacgtggtgaaggatgaagtgaacagcggtgcttggcatataagccagccctcaaacaag
219 2696767 MSL2 YES cttcctgtagctggtgcaaagactatgagcagtttgaggaaaacaagcagttaagcatcctagtgaactgctacaaaaaactatgcgagtatataacacagac
tacactggcacgggatataatagaagcagttgactgttcttctgatattttggctttgcttaatgatggatcattgttttgtgaggagacagaaaaaccctcagatt
catcctttactttgtgtttgacacattcccctttaccttcaacctcagaacccacaactgatcctcaagctagtttatctccaatgtctgaaagcaccctcagcattg
ctattggcagttctgttatcaatggtttgcctacttataatgggctttcaatagatagatttggtataaatattccttcacctgaacattcaaatacgattgacgtatgt
aatactgttgacataaaaactgaggatctgtctgacagcctgccacccgtttgtgacacagtagccactgacttatgttccacaggcattgatatctgcagtttc
agtgaagatataaaacctggagactctctgttactgagtgttgaggaagtactccgcagcttagaaactgtttcaaatacagaggtctgttgccctaatttgcag
ccgaacttggaagccactgtatccaatggaccttttctgcagctttcttcccagtctcttagccataatgtttttatgtccaccagtcctgcacttcatgggttatcat
gtacagcagcaactccgaagatagcaaaattgaatagaaaacgatccagatcagagagtgacagtgagaaagttcagccacttccaatttctaccattatcc
gaggcccaacactgggggcatctgctcctgtgacagtgaaacgggagagcaaaatttctcttcaacctatagcaactgttcccaatggaggcacaacacct
aaaatcagcaaaactgtacttttatctactaaaagcatgaaaaagagtcatgaacatggatccaagaaatctca
220 3188391 — NO caggggtacacccacatctattgtattagacaaatcacagagggattgcaacagaacacagatttttctcactgttttttctctggttgatcgggatgcattatcc
accagaaaacactgtagacgactcactcaccaggaaaagagcatatgccagttggaataaataaaggggaagagtaaggaagaggctgtagaattatttta
taaattatcaagtcttatgagccaggtgc
221 3846196 — NO tctggccaatgcatattacttaagggcaatgtcgtggccagctgtggtggtctgggctctccctctgtatcgcctggggaggctgctgaggtgactttttggaa
gaaaacacgggatgagtgtatgatggtggctgtggagaccacccaaaatcccggggttgggggcaatagtgaatgaatgggaccatctgcgtgggtccct
acacgagatgcttg
222 3070747 — NO gagctcattctgcgtttcttattgcttg
223 3821522 — NO gtagataaccatttgtcgctgctttttctgttaagtgttcaccacttgtatcattggctggcaatacctggtttgtcatagttt
224 3875001 — NO agctcctccccagaataccatgctc
225 3279450 C10orf97 YES ccaaagtttaattaatctcctgctgacgggacatgctgtttctaatgtatgggatggtgatagaga
226 3541293 PLEKHH1 YES tctttctctggcctggtctacaagaatgtcac
227 3547709 TTC8 YES cctggaacgtctttgaaactccctggaactaatcagacaggagggcctagcc
228 3875261 — NO gccaaccttggtttgtgcagtttaaggaaaaaagccatctccataacatggaagtgcaagatgaagcagcaggcactagtggggaagctgcagcaagttat
acagaaaatctagctaatgatgagggtggctacactaaaaacagattttcaatggagacaaaacacccttctattggaagaagatgccctctaaagctttcata
ggtagagagaggtcagtgcatgggcttgaaagaacaggctgattctcttgctagaggccaatgaagccagtgagttta
229 2584791 — NO cactggaagaatataggttggctcagacagtccataggaaggctaaataaccacgctcaggaaatgggccttagagagtgggaagagaaaatgtatctaa
acttatatctcagtaacagcttgataggacattgtcactagcagtgccaccactaggtcctca
230 3204563 KIAA1539 NO ttgccagcactctgaacccatgcgggctaatgacctgcccatcctg
231 3356165 APLP2 YES cgagactctggatgttaaggaaatgattttcaatgccgagagagttggaggcctcgaggaagagc
232 3650891 — NO tacactccctcagggacagtcttgccatttcccgtttttcattcttataaacaatgccctggtgcaggggtcagcaaacttttctataaggagtcagataatctttttt
ttttttttgtattcccttttggcaatttgtttaattgagataaaattcacataacttaaaactcacccttttggtgtatacgattcagtgctttttagtatattttcaagattgt
gcaaccaacaccactatctaattccagaacatttttatcaccccaaaaaggagccctgtgccaattagctatca
233 3829699 GPI YES actgaagcccttaagccatactcttcaggaggtccccgcgtctggtatgtctccaa
234 3971251 CNKSR2 YES cctcttatacctagaagtcccacaagcagcgttgccacgccttccagcaccatcagtacacccaccaaaagagacagttctgccctccaggatc
235 2359255 — NO agttgtggaggcatgtttataagcagatctgagttttgccacactggaatttatttat
236 2811000 — NO ctgggtctaggaagccaggtactttgtgctgtttcaacaagagctcttctgctttaactagttt
237 3391986 — NO gctggagaagttcgtctgggacaaagagctctggcctcatgcctgtgggtccagcagtcaaactgggacagactatgtgaaaagggacccac
238 3888361 — NO agcagcctcccgcttagcggagagtgggatgagcacatgcgcggccgacagggaagagtgaatccagagcagaagtcaagggcaagactcgtgggg
gggggaagaaagggacagaagccagctcccagcaataaaggtcgggttattttgttcttttgtgacatgccctatatc
239 3897502 — NO tctcctggggacttacatagctgtttggtttttcaacttgattgaagaaagttattcgggggatctgtccaattcacaccttctgttccctgatcaaatactttagggt
caaacataaggttttattgatttttgctcaagcaaagaattaacatttttgataaggaactgtaatggcaattataaggtaatatggtgtatggtaatattatgctgcc
agaggaaacatttgactatgattaaattcaagcccagtactgggtagctctagataattaaagataattttatccattcaagtcccctctgttaagctgcacattga
ca
240 3235381 DHTKD1 YES acagtatattgtgagcatggtcataaagctgccaaaatcaaccccctcttcaccggacaagccctgctgg
241 3286657 — NO tccagtgaggccacatcatgacttcccccatgaagacatcgaattcacggctgccttcacctttgtcctgtcaatgtctgatctttcctttcaattacagcacgag
gctggggttcca
242 2714224 MYL5 YES tggaccagatgttccagttcgcctccatcgatgtggcgggcaacctggactacaaggcgctcagctacgtgatcacccacggggaggaga
243 3331851 GLYATL1 YES tgaaagtagagcattcgagagcactcctcttggttacggaagatattctgaagctcaatgcctccagtaaaagcaagcttggaagctgg
244 3356559 — NO gccatggttctcttgtggtcagctcttgttctaatccttagcgcccatttggaaaccagttatggggaaagcacaatgtaggactcttgggactctgcacctgac
tggctggctttccaagatcactgagatggctcttcctccagcatagaaattgatggctggttatccagacagcaacctcttttgcccatgtgcttggtgctctgtc
atggcgggaaaagtaactatgcacagatcatgattatggtattagattgggtacacatgaaattgctagtatgcacctattttgatgtatgaaaatatcattttcat
gagattcatcctaatttatgctatgtatggggcctgattgccctaacagctcatc
245 3636325 — NO atcagacaccgcctattcaccagctcatctataaaaccccctgcatttcaccgcagaactggaacctatt
246 2539613 — NO tccattcttgcgcttaaaaactgtacctaactccctcccatagcagacagaataggataggcttcttccctacctggtgttcaagttctaccactgccctcctccc
ttcccccatttacctctctagaattaccaggtatctatgcatacatgaattctctgcttccattagatttacttgtcattccccaaatacaccatgcacttgcatattag
caaagccaagtttgtctttcacaaatgcagaggttaaataagagttaaggatgaaggtaaaccaaactttatttatatactatattttaccaaatatgatttaaggat
ctctaggcagtgttgtctta
247 2860647 — NO gcaatgtggaccagaccatcgacaacccctatgccacctttgtcaagatgctaccggataaggattgcctctacgccctctatgac
248 3143676 MMP16 YES cccgatgcggtgtacctgaccagacaagaggtagctccaaattt
249 3492475 — NO tgggctgaccacagactttaccacaaa
250 3698355 ZFHX3 NO gtccgagcctccgtactgggtgcaatgaaagc
251 3364564 — NO attggcgtggttcttccccaggataccttatagagtctagtgaacttttcctgtttgtggaaacaatcaggctgggtttaaatgaggacttgtctctatttggagcat
ttgtgagcgtgtaaggaaatgagtgttt
252 3101645 ADHFE1 YES agggagcttttgatgcctatgttgctgtcggtggtggctctaccatggacacctgtaaggctgctaatctgtatgcatccagccctcattctgatttcctagattat
gtcagtgcccccattggcaagggaaagcctgtgtctgtgcctcttaagcctctgattg
253 3015159 ZKSCAN1 YES agttcatggacctgagatgctcgcaagggggatggtgcctctggatccagttcaggagtcctcgagctttgaccttcatcacgaggccacccagtcccactt
caaacattcgtctcgg
254 2686624 IMPG2 YES atacctttcaagctgcatggccctcagcagatgaatccatcaccagcagtattccaccacttgatttcagctctggtcc
255 2897644 — NO atgttgggtcccaccttacatttagtttcatgtccccttagtttcctccaatctgtgacagtttcttaattttttcttgtcttctgtgaccttgacacttctgaagaaaaca
tttccttgatatttctgatgaaaatgattattatgtagaatgtccttcaacttgaattggtctttttctcatgattagaatgaggttctgggtttttggcaagcagagaac
agaagcgatactatatttttctcagtgcgtcatatcggggtcatgatgtcagtgtgtcttatactggtacactaacccatgtctgctaggtttctttccaatacagtca
256 3909740 — NO ggtggagcaagagccctgttggctgatgg
257 4049026 — NO ggcacagaagggcaaattccgcacattctcatttgtggg
258 2321582 — NO atggagccagaaaaacgcgtgcagcagctcatc
259 3304498 ARL3 YES ggcttgctctcaattttgcgcaagttgaaaagtgcaccagaccaggaggtgagaatacttctcctg
260 3533002 — NO tactgaatgtgcttggttttggacag
261 3568039 PPP2R5E YES ctcttgctgccgctgcagatccagtcttcctcc
262 3764440 RNF43 NO tgcggaatttctcggcacctacctgtagtatggggcacttggtttggttgcagagtaagaaggtggaagaatgagctgtacttggttaagcagttgaaacctttt
ttgagcaggatctgtaaaagcataattgaatttgtttcacccccgtggattccagtgggcccgaca
263 3790080 NEDD4L YES ttgggaaagcagataaccctgaatgacatgga
264 2658005 — NO gtattatcacatgactgccaggtgc
265 3029676 — NO gtctgtgggtggatagatccattaatggataagtaaatgagcaatgcttcctgggttgaggttttggattactgtggtcatgcactgcattggagatgaggtgga
aaaaccatc
266 3390272 — NO gagtgggcactaggaaacggattcaaagaggcgatgaataatctgagttttacaggtttaacaggaaggcataacattgtaagcaaagaaagaaaagatatt
ccagacaaagcatatgtgg
267 2642810 DNAJC13 YES ctggatggagtaagagcctctggtaatagagatgtttgtgtaaaaatgacaccaacccataaaggtcagcgatgggggttactcagcatgcctgttgatgag
gaagtagagagccttcacctcaggttcttagctacgcctccaa
268 2811129 — NO gatgagatattaactgctgcactgg
269 3070222 AASS YES tgagaaaatggtggatcatagaggagtacgggtagtggcatttggaca
270 3907114 TOMM34 NO cctgcctgaccttacccagagaagccatgggccacctgctctgtgcccgctcctgaaaccca
271 2790942 — NO atgttcccataagcaacagcctgtaaattgtcacatgtaagtcatctaataagtttagaacaatgaacaactcattttctgaactgggacaaacaaggaagctaa
attca
272 3043075 — NO aatcagtgttgcctggtggatagcaaatcaagtttcaaggttacaga
273 2354095 WDR3 YES ccatggtgaaatggtgggaccttgatactcagcactgctttaaaacaatggttggccaccggactg
274 2713294 — NO tggattgcgtaaaggtggggacctccagatcttccacgggaaaggtacgtttttcttgttgatattgtgaagtgtgtatggggttgtactttggcaccttgtagtg
agtcagtttccccccattggtgatcattgccaaatca
275 3220577 KIAA0368 YES agatgttgcatcaaagggccttgggttggtttatgaactaggcaatgaacaagatcaacaggaattggtttctacacttgtggaaacacttatgactggcaaaa
276 3531076 SCFD1 YES tgttactcgtattttggacaatcttatggagatg
277 2505303 RAB6C NO gcaggaagaaaacttcgagttacaggtcaggaaaagc
278 2644040 PCCB YES gagatcatgcccaattatgccaagaacatcattgttggttttgcaagaatgaatgggaggactgttggaattgttggcaaccaacctaaggtggcctcag
279 2938530 — NO gagaatgccggtggggccttcagcagcagcatcctaacagtgttgca
280 3625346 CCPG1 YES gaggccctactatgcaaaatgatggaaggaaagaaaagccagttcactttaaagaattcagaaaaaatacaaattcaaagaaatgcagtcctgggcatgatt
gtagagaaaattctcattctttcagaaaggcttgttctggtgtatttgattgtgctcaacaagagtccatgagcctttttaacacagtggtgaatc
281 2971361 — NO ctgcctagtattgtgctacagtaccagacaaaatcactttagggttttggggttttgtttttttaaacaaactggtatgtaatataaacttaggaaccaccaccac
catctcgagtatcaatgtttcagaatggaggcatagttcagtgaaaaaaatgccggcattggttttagttttgattcttgtttcaccagaaagcatggtggttggg
ggagctgtcaaagtactccggatagactcagcgccattaaataagctcaggcatatacggccaggagcaa
282 3026661 TRIM24 YES aagtgtgagcgcctacttttatttct
283 3108906 — NO ctgcatcgaaccagcgacctgggtgcctccccacccaagacggacctccacatcgggaa
284 3649134 MKL2 YES ccagcagccctttatcaataaggcctccaacagtgttcttcaatccagaaatgctccgcttccatccctgca
285 3729183 CLTC YES ttattgaagttggcacaccacctacagggaaccagccct
286 3900156 C20orf74 YES tcccaacaaaatcgtggcccaggtagcttgcgatgtccttcagttgctggtttcctactgggagaagcttcagatgtttgaaacctctctgcctcggaaaatggc
287 3907653 NCOA5 NO tttcctctttggaactcttgtgttgtt
288 3102604 — NO ttggtcttcacgcactgggtgtgtctgtaaatacagcgctgtccacggtgtctgtcctgcttccatcccaaattcaggctttagcttaaaacatctttagtttaatttt
ttaaaaaattcttttctttcccccagataaaatcttaatcttttgcactagactgttagccagggaaa
289 3863282 — NO gaagtgtttccagacatcccaattc
290 2920506 — NO gcttcttcgtggtcttttccattat
291 2319069 — NO ctgaagcagggtgcccgtttctacaccaaagagcggcaaaatgaagaa
292 2573693 CLASP1 YES gcttctgggcctgcagaacttactgaa
293 3022667 SND1 YES gtgcccgagtagagaaagtcgagtctcctgccaaaatacatgtcttctacattgactacggcaac
294 3570810 — NO atgtgggtggagatgatctttgctttgagaacaggattcattatgtgggctggtcaggagtgggaacaagagcaggaaggccacaggggattgagagtact
tctgtccccaacacactcatcaaggacgtgcaatcgggggccaaggctcattatggtgattttca
295 3847162 — NO tggccagctccctagtttgtgcttactatacctggccacgcctccctacctaaggccgctggcttaaccctaggggcaggcagtgttagatcagacccagac
cttctcatcccaccctcatcacatcggggagaggggactccaggggcgggaaggcaggcgtccctccatttggccagggtgggcggcgaggaggggg
tcactctgcaggaacactgagctctgaacacctct
296 2535304 — NO tcaacaacatgaatggcggcaacactaggagacatcc
297 2697615 — NO tgcagtggtactattttagctcaatgcagccttagattcttggact
298 2931795 — NO agatggcatgctgcacaagggattcatggttacagcgggcttgtgggactggggctctccaatacgtggttgggtttgtaaagaaatcaga
299 3011882 STEAP2 YES caggttattgaacttgcccgccagttgaatttcattcccattgacttgggatccttatcatcagccagagagattgaaaatttacccctacgactctttactctctg
gaga
300 3464921 — NO cctgataataagaggaacgaggacagctcagaaagtacaagtcaagaagccctgagaggggagtgaattcaggaaaccggacatttcaggtttgcctca
gcattgcatgagtttgaggaacaagaaaagatgaggatggattgtgaatgatctcgaatgtgttttgaaggtttttggaggtatttggattcaccctaaga
301 3541610 — NO aggtcgatgggctcagaattcactgacaggttcagatccagccgagaagtggagcatgtatggtattagtggcatttgaaggtcattagtggcataactattgt
agtgtaaattcaagttttattggtatattgtgtatagccctgcaga
302 3872499 — NO ttaggagccatcaacgagttcacgccggagaaagacctttcaagtgtggagaatgtgtgaaatctttcagtcataagcgcagccttgttcaccatcagcgagt
tcacagtggagaaagaccttatcagtgtggagaatgtgggaaatctttcagtcaaaagggcaacctcgttctacaccagcgagttcacactggagcaagac
cttatgagtgtggagaatgtgggaaatcatttagttcaaaaggacatcttaggaaccatcagcaaattcacactggggacagactttatgagtgtggagagtgt
gggaaatcttttagtcataaaggcaccctcattctacatcagcgagttcaccctagagaaagatcttatgggtgtggagaatgtgggaaatcttttagttcaatc
gggcaccttaggagccatcagcgcgttcata
303 2470335 — NO aaggcgttcgttatgtgggatatgctgttaccactgaacttgaagttatcaaagaagt
304 2887649 — NO ggtaagtggattgacctctaaactccctagaagggctgtagctttgaaggtggacatttattgggctcgcacgtgacacttattggggctaa
305 3522210 — NO gtgagaacctacatgttgggtgcccacc
306 3674221 — NO agtgagcgtttgagtgaaccagccacagtctctacgtgtcatccaaggagcccggcacagaccccgtgtcacccccatgtcacccgcagaccccgcgtca
cccatagatacgcaca
307 2560167 — NO gggacacagagcagttgaggatatctcttttctttcactctgttctgaaatctgcctcttcccaaaggtactccatgacccctaagatactcactctg
308 3041159 — NO ttaattcagcacaactcaccattcccactggaaacatactggcaattcacatcttccaaacaagg
309 3183335 FKTN YES gaggcactcaggccaaaacaggaaaaa
310 3204049 — NO gggcgccatcggatggggcaaagagatccctgaaaacgtattgccgggggacggggacttgcaggacaagaaaaccgtgggagaat
311 3393003 KIAA0999 NO gttgattgtaaacccacagtatctagcagcgttgtgccaaattgcccttgtgtttctctccacccaaaatatcacagctgctttcctcacatttggttcatccgtgtg
ctgttctttt
312 3598130 — NO gccaagtacaaagtgctgtcccatatattacctttatcatcatgacaagcacttgagatggtaattaacaactccactttaagtctgagaataatgaagcaactg
acccaaggctccaaagacagtgaatggcagagatgagattcaaacccaggtctccctgactcgaaagcccacgctttcccccaacaccatgttcttttccttc
cctgtcagaaagggaaataccaaaaacaaatgagggtatgtatgagggtttggctggagccccagtcagccaaagtctgattccaagtggactgcagggt
ccgtgttatctcccttgggcacaatctcaaaagcccagaattcagctgccttgctaaccttccatcccagtcttagtgagaagctaaactaacttctgggcctca
attacagcagatta
313 3681604 LOC728138 NO tgccatagaccctcacgtgtttgttgcattaattggataattcaaaatataaagtattatccagtttcaggataatattaagatctaaaccaatgaatgctctatgaa
aagttgtagattaactgatcccttaaaactaaaaacagcgtcttcataagcttctactgggggcagctaccactttcttcatcacatttcttatcctcaatagctgtg
ggcaatgccaaaatagc
314 2410882 ATPAF1 NO gttggcccttcacctagttgactcagccctcgatagtctagagcccaccccctcctcaggaactcaagagctcagcatttataatgagcagttggtaatgagtt
gccctatgtgcttgtcgcaagcagtcacagagatgagccctattacttgatattcaggaacaaaggtacctgaacattctgataattatctcagcatacttgagg
tttccttttttaagtgttcgaggttataacaagagacagccaaggacctacaagacagttgacttgattttgcacagtgtaacagcgcagttgcattctggccact
ttgaccttatagctcccaaatgatgagtttgtcatctttatgaactcatgacaggataataagcttgaagacctgctgtagttagatatgggctttaatccttcccag
gcaccagtcagctgaacaaaagcataagccaaacatcctgtttaaactgtagaataaccagatattcccatcaggttaaagacttcatctagatgatgccccc
cagagatgcctttagtgtaagtagctggcttggggtatcagcaaatttcaggtatagttagataaacaggtacagggcctgcatactattaaaccatagtttgtg
gcacccgcttttcta
315 2821250 CAST YES agggccagatgatgctatagacgccttgtcatctgacttcacctgtgggtcgcctacagctgctggaaag
316 3134070 PRKDC YES gattggagcaatgatgtaagagctgaactagcaaaaacccctgta
317 3888286 — NO agctccagttacatgggcctgttaacatggcagctttgtctataagcaaacccaggagagaaagacatagcagagatggatgtttgaagtctataccttccac
cccctttaaagagaaagtaacaccactccttttctgtgtcccttggggacactacctccatgtctggtcacatggctggactttacagcagataagcatactgtg
gcctgagaccatgattgtatgctttccttctgctgacctttacaatccctcaataaattgagctaacacagggaagcttttttaccaaataactgtgttgcatcatcc
tccagtttgcctggtgtccttaatcaatggaaggggaataagcaaactgagttttcttacaccttttgagtatagtgtttttgccatcatagatgtggctcctcataa
ttctccaacttttatattaaaaaaccaaaacctcaaaaattgtagttcatgtcagtcagtgatgactcatcttagaagtattttgtttttggatgtgtgaatgtgcatag
ttcttaaagtccaacattcatgtaataagacatcttgcatataacaatgacccttacgtctaagatgttaaatagatcctaagcctggtataactttattcaagtatcc
ttatttgcccctaaaatgtctttaatacacattacttgggttatttcttgaatgaacatacaggtatcccaatttctgatttttaagagaatggggtcttgctctgtcaccc
aggctggagtgcagtggtgcagtcatggcttactgcatccatgatcctcctgcctcagcctcccaagtagatgggactgaaagcacacactgccatccctgg
ctaatgttttcatattttgtagagttgcagccttgctacgtgacccaggctggagtgtagtagctattcacaggcatgattgcttgaaactcatggcttcaaggga
aactccca
318 3919790 — NO gcagggagtgcagaaaccttggagaaagtgagagattttccagccaaagggaactttgtgtttccctggctgggactcttggggatctttttcaggttttctgca
gtttttctgaattgagctttaaggcaactggatggattttgaact
319 3948965 — NO cttagctgttccagcggcccatgtttaaaagaatgtgcttctttttccaagtatttctgccgcttgcatgcactgagcttctttggaaaggagcaccatgcaggca
tattttccagacaggaccggatttgctcgttactcaga
320 2738676 — NO ctgagacctgaagcacgagagccaagtgtgtaagcaagtcgatgggattgggaagaagtttaggctgctaaaaaatttttacataaagcttgataagaggg
gatattgcatgtgaaataaacagaaattcagtaaatatggtggaagtgcaggatttaggggatggaaaaaaatactagtttcaaaaattgaggctagaagtga
aggtaggggccagattatgaaaagccttgtaagcaatgctaagaaacaatagatgtcagaaggacatgccaccatctaaaaagcagtcttgagaacaagta
attggataaaggtgacctgactaggtatttgtttttttaagtaaattgtgttaattttgttaggtgtaaaaatggcattagggtcatgttggggaaaaaagaatctctt
tcttacagatgaaattacatggtctctgagactgcttccaaaaa
321 2929182 — NO tgggtgtaaacattgatgatccttctaatactctgtcctcttaatttctctaagttctctttctagtgatcttgtctcccagtgtggtgggtatattctggctagaccag
gtcattgtttatggtggcagcccctctgtcatctgaatttaagcgtcccattttttcggtactagcatggctcactgc
322 3004581 — NO gcaaatgttttaatgggccctcctaccttacctgacataagataattcatactagaaagaatacctacaaatgtgaagaatgtggcaaaagctttagtgtattctc
aacctttactaatcataaagcaattaatactggagagaaatcttacaaatatgttgaatgtgacaatgtttttaactaggctgcaactcttgctg
323 3300811 C10orf4 YES tttggatttaggtggcgagtagaaaaa
324 3426258 — NO atggagattaagcaggaacttcaagaaagccaagctcttcttggtagcacaccagagtctgaagg
325 3645807 — NO agtggaatctctgaaactcaggtgtggcatcaacaaag
326 3976960 — NO caaatcccgggtggcagccataatccccaaagatgacccccaccccaagattccaaagaagctagtggtggtggaagcaaaaggaatgcagcaaggtc
agggtttcattgtccaagccggcctgacacctgccgccctgcccttgcccagtgcacaccctagaccctgggccggcctccatgcagctggaggccagaa
gacagcaacccatatctttgcaccctcctccatgccccatggcctgcctgcccagaaagatgccaccttcacagagccagtgctgtcgtctatatcattt
327 3981121 OGT NO ccgtcgccgccatttcaagaccgtactag
328 2391399 CPSF3L NO gtatgcaccggcttatgaacccaccaggctctgtccgagcggcattgaaatggccagagtgggacaggctggtgccctcagagcgcttggagcggccag
agactcgctggagctcccggggtgttgccgggcagggaggcaggggctggaggggagatgggccagctctggagggtgcctggttctgggtgtgggt
cagggaagaagtgaaggttaaatcagcgagtgacaggtgaaattccatttctgacaaagattatgggtttgtctgtgtctcactcgaatctctggg
329 2748879 GUCY1A3 YES tgcgaattggactgcactctggatcagtttttgctggcgtcgttggagttaaaatgccccgttactgtctttttggaaacaatgtcactctggctaacaaatttgag
tcctgcagtgtaccacgaaaaatcaatg
330 3063716 — NO gtgagtggttagagaacaatggcaaacaaagggcgaggcgtttaagcttctgtagagagg
331 3361874 TRIM66 NO tgggcttccgtgatcccgttttctagtttggggtaactgagtcttgaatgctttactagtccggcaatctttggacttaggcttctgccctttgagactcacatgact
ttctggtttggggtctggtcatttccctttcaatttttgaatctccttctctgttcagttggcttggcaaagtaccctctgttctcatg
332 2812780 — NO tctggaatgaaacagcgtaatgagatgagccctga
333 3065419 — NO ctacaaggatactcaggtcagaaaggcccaggagtacctacctcattcagcaacagtccagtcaaaatcttcctccccgacaatggcctatgaccagcctgt
tctacacattcctctctgg
334 3077669 — NO aagagcccttctcaatggcttaacccatagagccc
335 3652961 — NO aagcggaggttggaggaagccgtgattgtacc
336 2895678 SIRT5 NO aaagcagccgtggagacaaccatctt
337 2978057 — NO ctgtgttgtctcagtcaagcctagaactgaagctacctgacatcaagccaattgtccaggaccagcatttccagcacttccagttgtccatatctgcacttccag
gagtaaacaggca
338 3595946 RNF111 YES caaggccacttcatcatcaagcttctgcctgcccgcattctcatggaaacccccctcctcagactcagcctccgcctcaagtggattatgttattcctcatcctgt
acatgctttccattctcaaatatcttctcatgcaacatctcatcctgtggcacccccaccaccaactcacttagccagtacagctgcaccaatccctcagcatctt
cctcctacacaccagccaatttcgcaccatattccagc
339 3628693 HERC1 YES tataggaaatcatcaggagccaagtgtgtttatcagctgcggggacacatcactcctgttcggactgttgcctttagttctgatgggttggccctg
340 3734777 MRPS7 NO gtgagctactgccacgctgaaaactacctgtgggttaaggatgtagttcctttgtaagggtgggcaggcctcgtaagaaagatgtagcagcatattcactatc
cgttaatccttctttctttgaggctggaacttgctctctctgcccctatttccttgtaaagagggagcacattgacttgggaatttcctccaggaaactcagggctg
tttt
341 2806269 DNAJC21 YES acagagctggatgactatggccaatttggagaaagag
342 2849121 DNAH5 YES atgaatcccaaagcgattactgccccacagatgtttggtcggctggacgttgccacaaatgactggactgatgggatattttctacgctttggagga
343 3012989 — NO tcttattcttggccacgggaccaaccctcacaggggcactctatgcagaagcttccttcctaaattggaactcccactttgaccactctccttt
344 3184655 — NO ttgcaaggcccacaccacgtggctgagaagtcaactactacaagtttatcacctgcagcgtccaaggcttcctgaaaagcagtctaacagcaaaagaaaag
cttatattaaataaatagttaaatattaaaccttcaaaagaaagactcgacacaatgacacaaagcacattctggaggtcctc
345 2428776 RSBN1 NO gctgcccaagatgttggaacaccatgtgcaataaagggcttcgtcttggattttggccttattaccacaaccag
346 2502833 DBI YES acggcccgggatgttggacttcacgggcaaggccaagt
347 2608589 — YES ttccattgatgaattggataatgctgag
348 2781610 — NO cttacaggagaaatcgaaacacagctgctac
349 2810989 — NO ttagagtttatggaccttgctcttggtta
350 2489148 — NO cctctgccttcgctcgcgccgctctccttcagtctccccagggcctgtttcatggatagggtccccttgcccgcgtgaaagtctcattcctc
351 3239162 — NO ccactggctaataagcaggtctttattgagtgcccaacactgagtttagtcacaggtgcttattctggataattaatctcagtagattaaccttcttcagaatgacc
atgtatatcagacttctcttatccccaattctgggtccttattaacctcttccagggctaagtatttacccttccataaatcggatgttttcttaagcattttttctcctgt
catcactgaaactccagcctagttcttcacttgtatgcaattttcttgtaaccctgtctctcgttttggttttattgtccatatgcctattgagtgcttttccagttg
352 3573019 POMT2 YES ctgataggtcttgctggctacctgagtggatatgatggtacctttttgttccagaagcctggggataaatatgagcatcacagctacatgggaatg
353 3937196 DGCR8 YES ttgtgcccccaaaaagaggcgaacagaggaaaaatatggcggagacagcgaccatccgtccgatggagagacaagtgtgcagccgatgatgaccaaga
354 3154331 NDRG1 NO tgctgggcgtcaagcttgcataatgccgtactttgagggcggttgtcacaagtatcacaaaatgggtggcttaaagcaacagatatttattcccttttagttctgg
aagctaaaagtccgaaatcaaggtgtgggcagggccgtgctccctctgaaggtgctaggggagaatgctgcctgcctcttccagcttctggtggctgctgg
ccacacttggttcaccttagctagtagacacatcactccagtctctgcctccatcctcactcagcactctcccgattgtatctctgcgtctatgtccaaatttccttc
ttcttttaataacatcagccgttagctttagggcccgctctaatccaatatgacctcatcttaacttgattttacctgcaaagaccctatttccaagtatagccacag
tgataggtactggggttaggacttcagtatgtctattttggggacacaattcaaccacaacctacagcaaagggtaggtggcctgactgaggtggggtggcc
gatttgatggtagatccagaaacagaactcacttaggcctgattctggagacttccacagcgtcagtctaatgtgctgagtgccccgcctggaggaaaaattc
gggcatc
355 3697772 PHLPPL YES tcccagcgaatcagtaccgtggatctctcgtgttacagcctcgaggaggttcctgagcatctcttctatagtcaagatattacctacctcaacttgcgacacaac
ttcatgcagttagaaagacccggaggcctcgatacactctacaa
356 2611934 SLC6A6 YES gctatgacctcgctggggagctacaacaagt
357 3127807 — NO caaggaagcgagtctccgtgacacgtggtacaatatcatgcagtacacacggaaccagaaccaagaagaaatggctggaaaagatgaaagaaaaaaaa
agttgatatagtctcaaatgtagtgaaaaaacatcaacttatagattcaaaaagttcataaacccctcataaaaataaatgtaaagaaaaccctacctggacaca
tcatagtcatcatacagagcaaattttgtgcattcacaggtaacaaagatatgaacgacagctgactcaaaacaatggaggctcaggatgtgtgaaatggtga
aagaaagctgttgactcactattcacactcattgagaatatcctttaaaaatagtaagtgaagacgttgtggcaggttgaactttcc
358 3909039 SPATA2 NO agggctacatcaaccgacctttcgggtttcacggtgaagaagtactaacgcattgatctcagaggcggaggcctgcacttgaccatgtaggtggcagagat
cgtgggctggctgtgtccacgtgggagttcacttagcgactcagatatctcaaccaatggctgctttgttgtctgacaagggagaaggtggcacttccgttca
gattcattttgctaatctctccactccctgttcagttggttctttttttggggttttgttttgttttgttttgttgttttgttttttcctttaaagaggatttctgtctctgggacc
ctcgctgcacctacccctcccattgcaaagccaacttggactgggaagggcccttcaggtcaccaaacatccacctggagcggcgagctagaggcctgtt
ggcttgtgaaatgagccctcctgccacacggggcctctcccaaaggctcatcccttggccgcccccttcctaaacacaaggatccccagctggactcccca
ccccctggcttccccacctctccaggtgtcaaaggtgaaccgagtccagtattagctgaatgtcatttcgtacaccacagctcagtcagcccatggccttcgt
gaactttgctcc
359 2412620 NRD1 NO gtttctttgaggaacgcagcctgaa
360 3220615 KIAA0368 YES gaccctaaactactgtcaatggcatattcag
361 3521230 — NO tgctgctgacatcacgggccctgggtt
362 2327492 SNHG3 NO gacaatctttggcagacttggagcaaaagattgaggtgcatttcatgcctcctt
363 3557645 AP1G2 YES tgtcaacattcttggtcgcttcctactcaacagtgacagga
364 3709227 — NO tgccgtcctcagtgaatcacagcagcttcaaaggactcaactggcaagatttcccacag
365 4021348 ZDHHC9 NO gagagcaagtaagctgtcccttttaactgtttttctttggtctttagtcacccagttgcacactggcattttcttgctgcaagcttttttaaatttctgaactcaaggca
gtggcagaagatgtcagtcacctctgataactgg
366 3030989 ZNF862 NO agggcttgaccctgcctagatcctccttaccaagaaagggctgaaaagagagggcatctggcatgctttttgccacttctgtttctaggttatgtacttcatgga
atatctgggcattgcttagaaacctgtgtcataaattggctttgggcaagaggctttgagttggaagaaaaggtggaaagaaagtgcttgggggcggagttc
agggatttgacgggattgccagcgcttccaggccgtgtcatccaagaccagtgtggttgtgggcacattagcttggagacagtggcagcctcttgggacta
acatcttt
367 3035657 — NO agtccggtggcttagatgacaaatggaggtagaggacgcattctcgcctgttatttcgatttttttctctcctcaccctgaccgtcacgttctcaccttttccacctc
aatccccagtcacactagcttcccaggattaaaatggtctct
368 3626930 — NO tgctttcacttaaggcagggctgttgagtcggtgaggggatgagggcatctcaaaagaaggctggctttcaggattgcacagagatgttcctgctcccagca
gactggggtaaaatttcctgggaatgagggcatttctga
369 3091396 — NO caagtgagagtgattttgttacatgggatacattgcatagtagtaaagtctgggcttgtagtgcaaccatcacccgaata
370 3323928 — NO cagtgcatcccggaaaaaagagagcaaa
371 3326853 TRIM44 YES tggccaagaggaagtgtccggaccatgggcttgatttgagtacctattgccag
372 3402333 — NO caaagtcctttgcaagtctcacccttaagcgcgtggggactgtgt
373 3796317 — NO tcacgttgctggctaccctcatatgtgtgatgactgttagttgtacaattacatttaagaaagaggattacattgctagctggaatttcttctactattataaaaatag
aactgttttaccaacaagtctcttctccgagtgggacttgatggtaactataactgggatagggcaaatcaacgtcatgggtccacaggttttgctttaa
374 4020467 — NO tcccaacaagttgaaccttgcgttacgataaaagcagatgtggcatccaatcctaccacccagcaaagagaaaccccaggcattcaactgcagc
375 3180404 — NO catcgctgtgtgcatctaactcttgattcacggtctgaccgacgccttggtttctggagaactgccctcgtttatggaagagtcactgtcatcaggagccatccc
agggagaggctcagtgggaagtgtaaaggtggagcaagtaaaccggctccagaagagaaggcgaagaaggactatttctgtttagatttgcttaaccgca
ttttcactttcttgggaacccctgatggagttcaaggtcatagaagagaagaaatcagacactgctacaggactcttgctcttggtt
376 3781848 — NO gaggaagtgtctggtccggtccctagagcatggcaggtatgcactcaatgct
377 3868844 KLK11 YES tcaaggcattatctcctggggccaggatccgtgtgcgatcacccgaaagcctggtgtctacacga
378 2396267 — NO tggggacggcaacaccgcgctgcaagtcgttatcattccg
379 2862752 GFM2 YES tggtggatgtagtaatgaaagaaaa
380 3869672 — NO ggagttgcatccttgcttgactaaaatggaagccgtattgattttgaaatgaaaagcttcatgatgtagcatctggactttcactgtcc
381 3876038 PLCB4 NO taaggatttcaacacacgtaaggccatgtttctgatgttatag
382 3879228 — NO ggggagggacatgacttcctgttacgggatgaggaagtagaggttcatggagga
383 2399914 — NO ttagacttgaaagaacctcgttcacctgccacatgctatcctagggaattaatagcttcccatgtggacactcactctatgt
384 3142073 — NO ggggaacgaagcctgacaactcctaagtttctggcttctacaaccatttagtgaaggtttcattaatggcaggcaggagtacagttttagaaggtctggactgg
agagacatttgggggaatcatccgtgagtatcgagagttaaagacatgccaggaatagtgtatacaattaaaatagacaggggcttgggaaatgccagttcg
cagatatatatttgtcataagtgaactaaagaaaaggtatatggttggatgagcttaaacccagcatg
385 3777286 ARHGAP28 NO cgcagttcatgacttgtaccagtgaaggtagcaaggtctgtgtgttggtgatgaatttgcaggggatcaggctgaagaaacaagacttgggagagaggatgt
gagacctttttatgacatgcatagagttggcacctcagcctttgcatggtagggagctagctgaaggctacctccatgacagatgtacactttgaaaagacag
gccgggtgcggtggctcacgtctgtaatcccagcattttgggaggctgaggtgggcaaatcacttgaagtcaggagttagagatcagcctggccaacaca
gtgaaacctggtctctactaaaaaaaataaaataattagccaggcatggtggcgcacacctgtaatcccaactattcgggaggctgaggcagaagaattgct
tgaacacgggaggcggaagttgcagtgagctgagatggcaccaccgcactccagcctgggcgacagatcaagactccatctcaaaataaaggaagata
cagctaatctatatttctttcaccagagatcaccaccactaacaattcatactggtcgtttttccctgaatgttttacctatgtaggaaaattttacatcccaatttttaa
tttaacactatgaaaagcatttctttttataataaagacactctattagtatacttttgatggcttcaaaactacttttgtatagatgcaaaattaaaatatcaaattgttt
cttttgtttgtttgtttttttgttttttttttgagacagagtctcactctgtcgcccaggctaaagcacagtggcatgatctcggctcactgcaagcttttcctcccaggt
taaagtgattctcatgccgcagcctcccgagaagctgggactacaggtgtgcaccaccacccccggctaattttttgtatttttacaaaacacaaagagagac
ggggtttcaccatgttgggcaggctggtctcaaactcctgacctcaggtgatccgcctgcctcagcctcccaaagtgctggg
386 3851492 — NO ttttttacggattcagtgatctggacgggcacatactaccat
387 2712928 — NO gtgagtaaaccatggcgtgtttgttggccaaaagccgcaagtctttgaaaaggtgaatcatcacttttccattta
388 3060349 — NO ctctggaggcttcttgtcagtactagaaactaatacttggtgaatatccttttctgcttccattaccttgtatgaaactggttccatttatacactgagattagaagca
ttcataagtgatgcggcaccacaaacacagaagatcaaactactcacagtgtggagaaccatgtcttttataagtgtgatgtgcctaaaaccatcatc
389 3504762 ZDHHC20 YES aaaccccaaaactgtccaggcatgg
390 3543824 — NO agtcttttataagtgttggctatcattttttctcatctatttccttgcttctggttttgcacactttaccatccacactgccatcagagtgatcacacctctcttcagtagc
tcccatcatctactgcataaagctgagactgttagctagactgttaggcacctttcccacacgatctggctctgccccacttcccagcctcagcccacatggct
aaacaa
391 3781951 LAMA3 YES gatttgggcttaccacctactgaccacctccaggcctcatttggatttcagacctttcaacccagtggcatattattagatcatcagac
392 3216926 — NO aacactgatctccacgagcacaatcatccaaacggagatgggaacccctgttctaactctctcagaggcctgaa
393 3448246 — NO ctctttggtatattattgcagatgttgttatttcacagttaggtaaattagacataaaaaggtcaaacgacttgaacgtgctaccataaaaggtcagtgataaagc
cagaagtcatttctcagtgtccatcataagccacc
394 2693224 OSBPL11 YES ggagatggctgggtttatcataaaccactttggaaaataattccaacaacacaaccagcagagtga
395 2672926 SMARCC1 YES tatgttcatgcggatgctcctaccaataaaacactggctgggctggtggtgcagcttcttcagttccaggaagatgcctttgggaagcatgtcaccaacccgg
cctt
396 2914136 — NO ccatccgttcttttagctgacttgaatgactctaatgcagtgggttgcaggtttggctacttacctatgtactctgtaaacatccagaggcccagggatattctga
gccactgtgtgtgaatggagtttggccatctgtagatttccgcagtctctccaggtgatcgcactgtgcagcctcattgctc
397 3210858 — NO tttgctctgaaaggcagtttctgtataggttcctccgagtgaagatcagaatgttatcagacactggctgtagctcagatgaca
398 3853401 AKAP8L YES acttggaactctgggacaaatagag
399 3605225 — NO tggacccatctcagcagtgctcaaaccaatgcccaaactctcctgcttaggacacttctccactggccaccctgaggccaccacacctcactggccactcct
cctctatcttctctgctggctcttcctcctctatggccacctaaaggatgggtgttacacactcaatcct
400 2377461 — NO tggagttggccttgttaactattaaacacaaaagcatgtgatagttacctgagagatccatgcaggggagagtccaggggaaggtgactgatcactgcttcc
cagggggaggcagaaaatgcttcctggaggagatgatgggtggattaaggaagatgagttgagcaggagttgtagctaccagccagggaggaagggta
ttcagagcagaggaagcaaggtgagcaaaggcaccaagatgtgacactactggactgccaagcta
401 2934549 — NO gtgtgctactggcttatggctgatacgtaagagaatctcatctatctctaaatgttctgccttaagccgcacaaagga
402 3185031 — NO tggcacatgtggattctataccttaattaaagccactcccttacatacacacatttaggtatcgccagactcgcctgatgaggaataattattctttcctccatattt
cttaactcctgtcttttccatgaaacggcttggcattaaactccttcccaga
403 3560964 — NO gtaatgtggcggtcaaaaccggcgctggaaccacgggacatgtt
404 2732616 MRPL1 YES aacgtggagccatttaccagtgttcttagtttgccatacccatttgcttccgaaatcaataaagttgctgtatttacagag
405 3150536 — NO gccactcattcatggttgttctatgttccatgaactctaatagcccaacttatacatggcactccaaggggatgcttcagccagaaagtaaagggctgaaaaag
tagaacaatacaaaagccctcgtgtggtgggaactgtggcctcactcttacttgtccttccattcaaaacagtttggcacctttccatgacgaggatctctacag
gtaggtta
406 3774169 — NO atcgctgtaccattctggggcactggagatggcagctgagaagcagagaagctggagacctgaagcctccacccttggctgtggctgccgagagaggcc
cctgcagagggagccccaggccacacccagacaccacagccagctcacagtgcggccagagggcacaggctgcttggggggtgagggtccccattc
ctgccacctctcacagaccatgacccacagggctgggggcttcccctgggagaaagtccttccctccccatggcccagccctggggaaagaaagcagag
actaactcagggactgcagtaggctgaggacaagggaggtgggcttggggtgaaggccccccctcactcgcagagaagggacactaccggcagtaga
ggacagggaggcaggacgacggcagttagagacgaggcgtttcaggtgaactgtatgtagtgttactccggacgtgagcatggcctgggtcagtcgaat
gaaatgagctgggcctcgctgccctgtgccggcggcccctgtgcctgcggttgctgggccacggggggctgctgctgggggggaccgccagagggtg
ccatctgtgcaggaggaaagcaggcatggccctggtcctcccttccccagcccagggaggaaggcttttgtcccagcagagccacagacccacaagtgc
ttgtaatccatgtccacggactgcagctcatg
407 2987860 — NO cccgtgtttcgtgtacaacatatgatacatgtgacagttgacaagagtgcctgagtctcagagcaggaagagttatcctgcctccacatgcattgaagggaat
atatgtcacacgttactagccaggctcagaggagaacacatctcatttacaagttcaaatctgaaagggagaaatgtgctagtatttagtggatcttgaggaaa
ctagggatgtgttacccatctgtgcaggaacattagatctagatggggctctcctagtcaaaacgctga
408 3829652 — NO atgtgactttacaaccctcggtgtcctcctggctgctgggccccagcctcctgactgttcagctcacacacgtgaacctaacacctgccttggtcccctgctcc
atcttctagacaactcatgctgaggaccagcccacaggaggaggcctccgagttctctcttgacgtcttcaccttgaccattttttgccaccattttagtctgtcca
ggc
409 3900228 C20orf74 YES gaccaaagcctgtgtacattactaccactcgagacaatgagaacatttacagtacaaagattccatatatggcagctcgtgttgtttttattaagtggattgtaac
cttctttttggaaaaaaagtatctaactgcaacacaaaacactaaaaatggagttgatgtattgcctaaaatc
410 2858280 — NO ataaaatacaaactctccaacaagaccttttggccatcaggaacgcagca
411 3088555 ATP6V1B2 YES aactgcccggttcttcaaatctgac
412 3850502 LOC147727 NO gactgtttgccaatggttgtatttagtaagatttgtagactctgtttttcttttgacacagctgcaaggccaacagctgtgcaaagccacaagttatgctaagtcag
cagttatgctatagattacatgacctgtgactgtatcattaactgcttttgttttgcttctgtaagtttgcctataaaaaccacactcagtctttgttcaatggtcagctt
ttcagatacaaatccactgagccggtgtacatctaaataaa
413 3946288 TNRC6B YES tgtggacaagcgagcgatgaatctcggggattttaatgatatcatgaggaaggatcgatctgggttccgtccacctaattccaaagacatgggaaccacaga
tagtgggcctta
414 3430162 POLR3B YES agtctggttgaatatttagatgtgaatgaagaaaatgattgtaacattgcactgtacgaacacacaattaata
415 3751732 — NO gaatatgcatctttacaagcatccacag
416 2347259 — NO tggctgcctgacattattgggtgct
417 2421262 — NO ctccctgcttggcttgatgaccttt
418 3886689 PABPC1L NO gtatggtcttgggtttctgctgagaaatggcttgtaggtggggggttaaagttcctcacacctctcctgaacgggaggaagctgctgttcaccagtttccagtg
ctcaatgcgggcaggtggggcatctgtgcgtttggtaaatacatgatgtt
419 3951993 — NO ttgagcccagtggcgggactccacgacgtagacctctctccttctgcc
420 3966982 — NO ttcctgctgaccaacctaattctggtttcatacagggcagccaggtgcccacctaaaagactgcacttctcaacttccagttgtttctatggataatggttggaag
cagaaattgggttggggcttccagataatcccccctcacagggactgcttcaagagaaagggatgccctttggttctttctcctttccactgcctggaatgtgat
gtctgacactgtggcagccatactggcataatgaggccaactctctgccatgctaagagtggcagagctgggaattgaaaagagcctgctagccttgggtt
gcttccccttgatcggctcattacttggaa
421 2756515 MFSD7 NO tgagcgccttgtagtccaggttgcccgccacatcgatggaggcgaactggaacatctggtccacctgcgggcgggggcgaaagggctccttgcgggctc
cgggagcgaattacaagc
422 3261869 — NO tttttgtattctagtcgttcagccccctcccctcccatcttccagcgcttctgaacaactcctactgttctcttcc
423 3391839 — NO ccctatagattgtttgaggaccctattaaatattgtatagcctctaggaataagcctttccattgacttgctgtgataaacagatcttttgtcagcgactcttaaaata
caaaacagccttgggcagtagagtaccac
424 2437406 C1orf104 NO gcttccctgacctagacagtcctgactgatggtccaacctcaatcccacttatttttggctaggccttcctgggagtcataaaagagatgaatccattctagagg
tgcacagcctgtctcttccctcacaaatgtcagtccccaagtcattctgatccaccttcctaatatttttgccacctccaacttctttcaagatgaaaaggaaatgt
agagaagcaaggtcagggtagacacttaatcccactgactgtctttaatccactcttctccctctcaacctggatgatctccacactcctatccatactcagata
caggatatattgttcccctattatgtgctaagcactttcatatcccttgccttgcttaatctttacagtcctgtgaagtaggaattttatccccagctgaggaaagag
actgagcgagaccgacttgctcaaggtcacacagtttttcaccaggggtagcagtgttcacg
425 2802671 — NO tagagttagagtcagggccctggtccctggtgctctttcctggtcgcttctcatagccaggacgcttgcttacattagttctcaaccccactgggaccaatcatttt
tattgccaatctattttggggctctgttctcgtggcaataaatcattctttcagagctccctatttaaccttgtgagagcgtgtgtgtgtggtggaggtgcttacata
aatgcagtatttttaacctgcctggcacgctttaggttggcgtta
426 3415835 ZNF740 NO aagtagggcacgctctcagagaccaggatagagagtcagggaacctgggaaagagtagtgccagttccgggtaggctgctgcaccaggccctaccagc
tcaggctataaacagtctgctttgccccaagtttttccgtccacccccaacagccttgtcatcacttagctactgatcacgcccatggcttgacattggagggt
tacattagtggagtccgccacagcttcgaaccctctccccagatgccctttgcctctgctgtggccctggggttttatcaactg
427 3764797 — NO tgggactgtcaatcattggctctgcctctctgaccacagactaaatatatgaccagtctaacctgttaagcataacaatatggacactgggagagaagcctctt
gaaatcctttgctgaacggatcatgtacaagctgccaagagttcatctc
428 2431813 — NO tgatgcacagtttaggagcaggaaagccatgtcttggatccagga
429 2468734 — NO tgcccaagtccttgaatcctacagaccttgctaatggctccgttcacgacacccaactggtcctgaactcttaggattaacccgtttgcttatggctgaggaa
430 2512616 — NO cctaactaggagagtgttttcaagggagagattgctatagcatcagcctcagggtaggagaatgagcttaaccatgagatttaggtttgagcatgtttactata
agtaaaaagcattttcctggagtctggcaaatattgtggaagatgtac
431 3242348 — NO aagagaatgggcaaagggagcgggtaggatggcggccgcaccaccagccacggactgggagaggcccttctgtgtttccagatgagaagagagctca
aggaatcccaggaatagactccatggaaaagaatgaaaaaaatcagagaaaagccaaatatccaaaagag
432 3316358 CD151 YES tgggtgagttcaacgagaagaagacaacatgtggcaccgtttgcctcaagtacctgctgtttacctacaattgctgcttc
433 3473828 TAOK3 NO tcccactagcgatcagctgacattcctaactgaaggctgcaatgtgttgcttattcattttgtaccgtgggagctgcggggactagcagagagctaaacta
434 2453074 C1orf116 YES cccggaagctgccacctaatattgttctgaagagcagccgaagcagtttccac
435 3144603 C8orf83 NO caggaatgcaagcactgctacctaactaaagaccttggctttggaaacatcttaccccttggcagctctccagagtttagacttggcagcatcaaagac
436 3035937 GNA12 NO agcactcctcccacgggcctgggaaggcaaatgtgttttctgaactgtgttgagaccgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgttggggtgt
cttgtgaagtcctgctaacctcttgtcagcagaatattcgagaaatgc
437 3854106 C19orf42 NO cttcaaagtggagtagtggcacagagaccatatggcctgcagaatggaaaatgtcacctgtttggcctcttaccagaaaaatttgccaaccgctcaactagg
gtgtgatggagaatcccaaggtgtcccttccctcccaaagccactcagggaatcatctgtacc
438 2604179 USP40 YES ttgcaatggggagtgacgttcaacctgggacagaaatggaaatcgtagtagaagaaacaatatctgt
439 2625696 PDE12 NO tagtgggacttttaagcatctctgaaataaaaaacttctttttacagacaagcattatagtttgagttacagacaacagtgtgtatatatgtaatatatatatagtaaa
atgaaatttaaatatgaagccaaactttttaaaattagaaactacaaatggttatactgattagtgtctagcctagagtggtaaccatgctttactaattcagttatg
aaatacattatttataatgcattagctgtattagctgttgcttttttgatgttcaggataactatgttatctcatttctgcatttaattaatagctcgagtattaaaagccc
actcccttcaagaaaagctttgattttccccagtcatgaaagcccttgtttcaaattctttaatctctgaacctagtatcataagaatttcctattttgataacatctgta
ctttcatattctgctcactatcaaatgtattgttaacacttagtaagtttgaaaatgaaggggttttatctgcatttgacattgaaccttgaagtactttaagtactcca
aggggaaaattaaagtggaagtttcttcggatcttgttta
440 2410545 POMGNT1 YES catgtggatgcggatgcctgaacaacgccggggccgagagtgcatcatccctgacgtttcccgatcctaccactttggcatcgtcggcctcaacatgaatg
441 2545098 HADHA NO atgtgtgtgcagaattctaggcagcaccttagggagggactgggatgagagaaagtgggacctggtgggctcaaccacacacacctgtctgtgcagatgc
tttgcccaggcttctcaccacggtgtaccgggatatta
442 2749561 ETFDH YES atgctggtgccgctagccaagctgtcc
443 2849125 DNAH5 YES ttcttcggaccttgggagcagcaaaaagagccaatccaatggatacggagtccacgattgtcatgcgtgtactacgggacatgaatctttcta
444 3022356 — NO gaacacctgcccaatgtcagctatacttcagctctcatttgcactattcaaacttataaagttgaagagcaacctacgcctgttg
445 2474026 — NO gtggtagcagttttccagatgtggatgcttcatgatctggtg
446 3160004 — NO tgctttgttgagggtgtaaggggaa
447 3795785 — NO aatgggaatgaaatacatgcctttttgtttttaggggtgctcagttataaatatgaaaggctgagaaaatgctaattgtacagtaagatcaactggacttgttttaat
aagacaataatttgaaattagtaaactattttatacaaatagtgctaaaactttggaaggtcctcaacctcctgg
448 2990169 — NO cttgggtatcacacaagcattactgacattgagttcatggaaaatacagaaaatatatacaaaattaatgccacagaacatgacaaatggctgtgaggggag
gacttttgatcaattgcttgatcttaaacttactttagaagaggtggccagtgcctgccaattggctgccatgtggatacttcttatgcttgatcttaagtgcttttgt
gtgtgacagctctacacaattccctagttaagagttacttctcaccaaccaaagg
449 3858632 — NO gctgactgcagattcaaccttctgagctcacgaa
450 2481311 KLRAQ1 YES gctgagttgcaggggaagtaccagaagctg
451 3726479 RSAD1 YES tggccctggggctacgcaccgatgtggggatcactcaccag
452 3847164 — NO ccatgcgaagtaccaagccctagttgttctccatccaggaggccgtgtggctcatcccttacccacagaccctcactcaccaccttcgtccctaccatccaca
gcacccgctggccctgaagtgattccttggtcctggacctggggttttgcattttgtctctgaggaggaggtcgcatggagggggaggggatggggatgtg
ggtgtatggacgggtggtgggtaggggcacgtctgatccactgtcacggcacctctggtgagttgtaatgcgttcgtgactccaactgactggtcttcaccta
acctgcttatttctctgccaacacctgggatgggggtttgtaaatccagcagggctca
453 2945519 GPLD1 YES cttcccatgaccacacacaggagtggggaaaccttacttgtacttcatcggttttcttccaaatcagcgacgggagtaacatttttattcctatcaccaaaccac
ctgaaaaatggactcctaaacttcctcatatgacatcacattaggctaatcatgtaccctcaatatcatcagggtaagtgtatttattctgttattattacatttgtagt
gcaagagctggacactctagaatcttccatgcacactactttgggagg
454 2960606 — NO ctaaggctggatctccgtttctttccacctgctccaactgtacccacagctgtgtctgactggctgccgtcattatgctccagtgtgtacatctctccactgacact
ggtgctctt
455 3275073 — NO gaggaggttgactcaggagaacttggg
456 3392454 — NO gatgctgaattgaactgggatcttcttgtctgtcaagcccttgaacagctttccctttaagcaacaaagatgacaagtttttgctattttggattagtgagagtgtac
gaaatggtttccctttccttccaggcaaaaataccaacagaatctggcttcggaatgaaagtgctaatttcatttggtgactttcagatttgaaatacgggcttga
acaggcattgtgcattagtcagctgaggcagtggaggttatttttacgatgctaattattatttcctgacagtgatttactttatgttgtctactgttttacgcccccaa
actagccattgttttaggaacagaattggttgggttgtcatgctcttttcaaagacaaatcttactattttatgcatagaaatactttcctgtaataaagaagaaagct
ttattgaagagaatcttgcatatgaaatgtaatctggataaatattcaaaactaataggtttatattttagtcttgatttttaaagtatatttttctgacatcctaaccacc
ttgctttatgtgcattaaagttaaatctgttttactgggatgcggctgaat
457 3428624 MYBPC1 YES catttgagatgcagatcatcaaggccaaagataactttgcaggaaattacagatgcgaggtcacctataaggataagtttgacagctg
458 3869530 — NO ccattacagcagcaggatccagtgacccgggatgctcacatctctccctgacgtgggcggagtagccccttcctcccaaggtcactgtcctgtccaacccc
gtgctcccctagcccgttgggaggtggacagtgagacatcttccca
459 3180781 — NO tattgggagtcctgtcagaagctgcctgctacagggtctttagctttccttagattttcaaagaggtttgtgatccaagaagaatagagttttgaatctagattttat
actaaacgatcactttagattttcaggagtgtgtgcctagtttgtgattaagtta
460 3319155 PPFIBP2 YES ccacagtgctgctagtaatgaaacctaccaggaacgcttggcacgtctagaaggggataaggagtccctcatattgca
461 3428631 MYBPC1 YES cttgatcctgcatatcaggttgacaaaggaggcagagtgaggtttgttgtggagctggcagatccaaagttggaggtgaaatggtataaaaatggtcaagaa
attcgacccagtaccaa
462 3435265 LRRC43 YES agccgaaagccgtgattccgatctacgaaggcgattaccaccctgagcccctgaccgtagaggtgcagatccagctgaaccagtgccgctcggcggagg
aggctctgcgcatgttcgccgt
463 3697431 — NO ggaaagcggggcagacaaagtatccaaaagt
464 3928125 — NO gggcactcacccaagtaatgtccaaacaatatttttccatgtcccccctcccccagaacacacacaggcaaaggcagagatgtttactgtgaggtcacatgg
catgaagcaaatgcagccttatctgtttattattacaacagccagttagcattggcaaatgtgctttggttacaaacatggtttctgctaataatttcatgaagaag
cttttaggatatgtgaccatttattcttagtataatcaatcattgaaggataaaaatcagagtataaaagtttatactctggcaaatataaatacatgcacagaagttt
ctgacagtttaaatttgagcatatttgaaatattaaaggcatgaaatttaaaaatacacatacgtgaaactatggtgaacatgttatgggtttgtcccatggtttaac
tctgctcagcccacgattcttagctgggtcagtcaatagtctatttttatcattttctaccctgttgtacagcatgatcatatc
465 2769166 — NO gtggggtcagagaagatattaggaaa
466 3545551 C14orf178 NO tggcgcatatcagcagacggcggtcactactgtggctcatttaaatctgtgttcagctccgggcctcttttttcaggaatccttgtttcgggacacccagtggaca
467 3899443 — NO gacttacctggagagcgcgagaactggtgtagcttacgtggagtgagaagagatggggaacatgtgaatgaggtcagagcggttgcaggaaacggactg
ctgctgtaggccattttaaagacttttgattttcctctgaactgccgagtattttcagcagaggagtaacatgatctcacttatttttaacgggcttactctggctgc
468 3182036 — NO aagattgaggagaagagtagtgacaa
469 3063084 — NO gagctgggtacagagtgcttcatgctgagcctccgggcatgcttcgtgtacactccgcacactctccacacacacacgttacatggcagcagtcc
470 3387617 MAML2 NO gaaagcctgtgtatcgccgtgactccgggcgcgagccagtgtcagcaaagcggctaacaacagacgagaaagagaaaggaaaatacaagctacttttttt
ttccatctataaagcggagcaaatacaggagatagaaccagattgcttattgcgagtccagaccctcagatccactggccggggatggaatgtacaaaagt
ggacagaaaagtggctggacatgactcggtgcaatttgctggaagtttgtaagtttgaccatcgtttgtaaattactctcggaagagtttgtctctcttgatactgt
attagaatagagccgggggtgaggaatagaaacgtaagcgggaaagaaaaaaatgtgttgaaggatctctctcagtggctagcga
471 3566496 — NO cctaagtcacgcctctggaactttggcaagttctatagaagagtcagcagcaggtgtgggtcaaggtcccaattcacttcctgcagctgtaccatcccttcctc
gttctgcaaattttctcta
472 3088581 — NO tgatctcatgatctcaaaacaaaggg
473 3120740 — NO gagcttggtttttggtcagaagccaagaaaaaagatcggagaagaaaagaaggaatgacctcaacttgctctgcacggaggacggggacggctcagaga
taaatagc
474 3399570 NCAPD3 YES cctggacgccagtgagttactctcagacacgtttgaggtcctcagctcaaaggagatcaagcttttg
475 4010188 SPIN3 NO tgtatcaaagtaatgtgtccaccggtgtgagcaccagcaactcacttcttcctcagacatctctaaagctggaaagattttgagggacaatatggtttccttcac
cccacaccaatgttatgaatgagaccagcagaccaacagcaaacacctaga
476 2638236 — NO tcagctctgcagccctacagttaccagctaaccttg
477 3683253 — NO tgaatgaatatggtccctggggctaaaagtaagaaaggagaaaaaaataaagcaacccccaaatttgatgagaaccctatagtccctgactgattgtttcctg
gccatcatcatcatcagcttcaactttgtcaacacacccttaatatgggtgtaccttgttttacagtttgccgagcactttcacacccattattggatatgacacaca
acccggtgagagtgctctc
478 2502720 MARCO NO ttcacttctctgctcccgaggtgtcctcgggctcatatgtgggaaggcagaggatctctgaggagttccctggggacaactgagcagcctctggagagggg
ccattaataaagctcaacatca
479 3378495 — NO aaaactgccctggaggatcggcacg
480 2642712 — NO atcattttgctcaggccacggccact
481 2798891 — NO catttcccagtgctgtatactcctatctcccagtgctgtttgctcccatttccca
482 3428610 MYBPC1 YES agagaaggaggccggaactacaccagcaaaag
483 3691119 — NO ggtctcgcgcgccgtcttctcgagag
484 3821139 LOC126075 YES agaccattgtgatgattcccgactcccagaagctcctgcgatgtgaacttgagtcactcaa
485 2349300 — NO gagaattgggaatcaagaatcagccctgtttccatcttagccacaccaacttatatctttatgattttcaaagcttttgccatgtgattctgcccccacaaaggcat
cggtatttccta
486 2638933 — NO tgcggatctccaaagcctagggatttttccgtaaaagagagtgggccgttctggttacccttttattagaagggtattccaccacagagagccggaggttttcc
agatgtgtgtaagagagcaggtgcgcaaggcaagcaaatgagcgcaaacagtattatggaaaacatttgagaagttagctccatgaggactgtgggctcc
acaagaggactcgactgggtagcctggtctgacacaggtacgtgaaagcagagtattgcttcaaagctggaaaccttccataggagcctcacactgttgga
agatgtactgctgctggttaaggtcaacctggggtgcaatgctgctgtcttcatcttcggtcccgaagtaatgctcaataagatcaaaggccttttggtagatct
cctg
487 2661085 — NO ttcctcacaaactggccttccatttccagcagaggcaaatcaaattgccttttccgccctcatctctttg
488 3037551 — YES ggcagtgaggagatcggtaacttgggagt
489 3215176 — NO tggccgtctgtacagaacccacctgcaaccaccacaccctgagcccatgtggccgtctcacctctaagtcacccaa
490 3410744 DNM1L YES gcattacaaggagccagtcaaattattgctgaaatccgggagactcatctttggtga
491 3439960 — NO cagagcgccagcaagcggccacagaa
492 3461262 — NO tcattttaactctgtgcagagtatcaaatccatccatt
493 2316284 — NO atgccaacgccgacgtccctgcgggg
494 3882865 — NO tcctagcagcacacatatgcagctctt
495 3685651 — NO aggggagcttcgtgatcctgtgcaccaagtctccatgccccttgttgtacccagagcaccatgctccccgccagccccctgtccacccctgcttagttataca
gccattgtccgttttgtgtagaacagtggctttcaagcttttgtcaccatgatccatattttaaattgcaaccctgttccctatgatacct
496 2854135 — NO ccgaggactgttgaattgtggaacatctggtggaaaatagcaagaggtgacagaaatgctaatggggcagtgagatgtagacttcaggcagaattgttgtac
ctgtcgagttggag
497 3314277 — NO gtctaaggaaaacaacaggctgcgcgaaatcagccctcagggtaacactgaacctggcgctcttccggcaccacacaggaggcgacgcccgggaaag
aagactgagcggctcctgtctgaagacgtctccatcagtccagcca
498 3724236 NSF YES tgatggcgtggagcagctaaacaacatcct
499 3746906 NCOR1 YES cacaggtatgaaacacctagcgatgctattgaggtgataagtcctgccagctcacctgcgccaccccaggagaaactgcagacctatcagccagaggttgt
taaggcaaatcaagcggaaa
500 3909730 ATP9A YES gaccacttcagattcgatcgtatgtgtacgcagaagagccaaatattgacattcacaacttc
501 3428460 UTP20 YES ttggttgtacagttggcacgagatctgcagatggatttctacccacactttccagagttttttttgactatcacctcgatcctggagactcaggacacagagttgtt
agaatgggctttcacctcgttatcatatc
502 2751975 GALNT7 YES gggattatttgccattgaacgagagttcttctttgaattgggtctctatgatccaggtctccagatttggggtg
503 3894100 C20orf96 NO tcccagcacctggagccttggatcatttacttccaggaccggatctccattcagaccctgatctacagtctccctgctccctctgcccttcctccctctttctttcc
ctccctccctccctcccttcttccccccttcccttccctcctccttccttcctcctctccctccctccctcctttctttcttcctgtggttttttcctctcttcttcccttcttt
ctggttggtgctgctgggccaggtgggaatttctgatta
504 3908236 — NO accttcagggtgctttcacaaatgagctactggagtatttttcgtatctttggttgatgaaaaggctcatctccaaacttaatggttgtaccaaggtgttttcattcct
tcaacaagtcactgagtgctttcttggaacacacagccttgcactgggggttatggggagggaggaagaggctggacagggttactgcatactgccggaa
ggagattctcatttggctgcagagtgtcgcaca
505 2407923 — NO gaggtctcccgtcactgggcatccagctgggtgctacggccgtggctcctgccttctgcagccctgtcagggcccaaggccttcctcatcagcacttgctcc
agcctactcactggagttgtgttctgggtgggtgtgtagaatactcgcactcctacttggggcatcagggagctctctagcaatttc
506 2571603 — NO ttggaagctaacctgccacattgacttaactgagtgaccccagttccaaggcagggcctctacaatttccagtttatctattgtttcctgtgtaagagcagatact
tactgtaagtccgtaagtgctactcgtaggtcaaacaaccttgatgatatcacacttcaattgtcttataaatcccatctgaaccactcctaccctatggtatatga
gccctgggtttgggtgctaatgcggggatccaccatctcatctcattgccgcctgagacacctacatggctt
507 3634205 — NO agcagatgtcagcatccgggtcacctag
508 3746967 NCOR1 YES ccactgtataaccagccatcagataccaaggtgtaccatgagaacatcaagac
509 3675286 WDR24 NO ccgcctggtcttgtgcccgagacgggcggaggctggaacttgagacctcaataaaggaagtagag
510 3809651 FECH YES agctggcaccattcatcgccaaacgccgaacccccaagattcaagagcagtaccgcaggattggaggcggatcccccatcaagatatgg
511 2793478 AADAT YES catattgagcagaggaccaaaatcgatgatctccttggctggtggcttaccaaatcca
512 3139792 — NO tgtgtcacttctgcattgcccagtattttgagttgggggaaaaatgaactcacctggccccacctcctgttccagtgtgaaatactgacacttgctgccagccca
gcctcctcacataagcattagaaatatcagacagtccactaggttagagcacctcattcatgaggttctgttatttattcggctctcccactaaaatgcagggcat
aaatttatgtgtctgctctaagactgcagctgtctgccccccctccaccctcctcctgcccttcctgtgtcagtgttacattcgctccccccacttttggtctcaggt
ctgtctcctttttgtttttatgggtgatttgcagtgattcagacagggcatccttgcatgttggcacttcctggaggttaccaggaggcagccatccttccttggctt
ggccaggcatccccgactccaccccactttccccttggtggtggaaaggtgggttggaggtgtgtactggggcacatagcccaggaatgttgctctgagaa
gaggacatgtgcagtagacacaaaaatataaggaagcaattatgttcatcaagccgaaagttgcagattttgaggaaatgtgtttagataccactacataata
aaagggaaaaccacttggcatttaaataacttacttcaagaggaaattatgatattttcagtctacaaatagagtggtttttaagccaaccttgagtaggtacaag
caaattataaacagtctgctcaaatgattttactatacttagactagaaaatggctcctcttctctctccctctggtccctatgtcccagtgctgtccctcatatgtta
caa
513 3296171 — NO acatggctctggtcgaaatgtgactgaagctttgcat
514 3470058 PRDM4 YES cttatttagctgacagaccacctcc
515 2830812 — NO tgggtaacagaacgcaactttgtctccaaaaaataaataaataaattgttacaatgaaagtggctctgtgttagccgggagtgg
516 3151504 — NO cttagggaatctgtttcggtggctcagagaaggatctgttgccaatcagccgatgccaggtctccggtgct
517 2978822 — NO ggcaggtccaggaactgggtctggagccttgaaagcagaag
518 3432174 — NO gtgcgatggaaaaggtatccaaagtgatactccctttgactctgagcatcagttgcccgtgtttcagtcacttcaa
519 3922854 PDE9A YES gaccaactgcccctgtaagtacagttttttggataaccacaagaagttgactcctcgacgcgatgttcccacttaccc
520 3225896 — NO ctggatctgccacctcttctttcggctgtggatggccctgggagacacgcctggcctcagatgccccttgacccaactggaggaagggtggggggcccag
cagaaaagcctgcagcctccctgggcaccgtttcaaagctgatgctgctctccctgctctgggtctcagctcctcccctcttctgcattgttgaccaacagcct
gggtctgacgcggaagcagaagaattcc
521 3981141 OGT YES aatcacgcagtggtgcacggcaacctggcttgtgtatactatgagcaaggcctgatagatctggcaatagacacctacaggcgggctatcgaactaca
522 3040366 TWIST1 NO cctctgcattctgatagaagtctgaacagttgtttgtgttttttttttttttttttttgacgaagaatgtttttatttttatttttttcatgcatgcattctcaagaggtcgtgcc
aatcagccactgaaaggaaaggcatcactatggactttctctattttaaaatggtaacaatcagaggaactataagaacacctttagaaataaaaatactggga
tcaaactggcctgcaaaaccatagtcagttaattctttttttcatccttcctctgaggggaaaaacaaaaaaaaacttaaaatacaaaaaacaacattctatttattt
attgaggacccatggtaaaatgcaaatagatccggtgtctaaatgcattcata
523 3847114 PTPRS YES gagtaccagttctgttaccaggcggcactggag
524 3903914 — YES aattccagagaagggtttgagtttggagttttatctgttgtaaaatggccctgcttttag
525 2545695 GTF3C2 YES attcattatattgacgctggttaccttggtttcaaggcctacttcactgctcc
526 2468742 — NO ggaggttcgttcataacacaccctagaaaccatgaaaaacatggagagccaagtggagtgagtgacccgagtttacaaagcctgcaatgatcattcttttatt
acctgacaggatttagggtaactagaaaaacaaatacaacttatcttaggcaatcacttctctatgatctcagggaggctata
527 3332623 TMEM109 NO ctgtctggggttggctctcttaaccctttctctgctcccagcctgcctcaccagggaaggttggaggggcctccctctggcttctgcatctgcgccagcaaac
atcactgccgttggtctctcatgacttaactggcttccctctgctgctgccttggcttcctcctaatgctcgtgctctcctgtccttctgaagttgctccttggccaa
atctccagct
528 3457669 — NO ggctttatcggatagggacagacgaggtaaggaaggttgtttaatgagaggccttgcttgccagcctaagcttttaaatttgatgccagtggcaacaataaag
tgta
529 3575429 EML5 YES gtggcagagatggttgtattcgtctttgggattta
530 3676065 — NO atgggggacgaatgccggctggattcaag
531 3541353 PLEKHH1 NO gggccctgcccagataaaattgttggtcttgtctgtaattagtattccaaaggttcaggtggtgttgcatctccgtatcaatgttcagctagtaggtaaagggaca
tatttggagggaactaactctggcctagctactattatgctcttcactttttcttttttattctctcaagccccagcatcatgcagtcctcagttgggtgcttacgtgct
cttctcttccttgcagcagtcctcaaggcagggcagattcctctttaaggtgctcgcatgttacccctgggttctgctgacccaacattagctacaaagtgggac
agtcccacagtgctccctcttccttgttgtggggaagaccgcaaaaagacctcttttgctttagtgactttgttcctactcaatacaggaagtgttgaccagcaaa
aataataattacaaaggctaagttctgatttattgttcctgactcccgtgtgattaactggaaaccctg
532 2428388 — NO tggagctctccaaattaagaatgggtagtgacaaactttgaacaggtaacaaacaataaattcaaagtatatttaggattaaacagtcaatttctaaatgggagt
ctatcatgtctcccctttgcaatactggccttcccaacaggaattctatacttgtccagtccaccataatgggta
533 2883068 — NO tttctatctcttcaccttacacacac
534 3686201 GTF3C1 YES agggctcgattccagcttctacggacacctcaagcgcaactggatctggaccagctacatcatcaaccaggccaaaa
535 2933137 — NO atgagcaaggctggtatctggagttttgataaagt
536 3098268 — NO agcctcagattctaccgaggcaggcgccccaaataccctccggacgctggcagcagttgcgtgcttcatctgtcct
537 3804158 — NO cagtgtgccattgtaatttattggtggagtgctatcattggtaacaatatcatataaatgtatttaacccctcctagcttttgaagtaagattcatgttagagctagaa
tttgtctgggtgc
538 3570485 — NO tggaggggcaggattacacactgaatcattggca
539 3666058 — NO ctcttggcttcaagtgattgatcctcccacctcagcctcccaaaatgctggaattacagacgtgagccactgtgcccagccagctcatcttcgaataataacag
ttttacttcttccttcttaatttttatactttttcccccctttttcttgcttcattgtattgactaggatttctgatacattgttgattagaggtggtgatggaggacatccttg
tctttttcccaaactcagggcaaaaaaggattcatagttgtgccattaagtaatttgctagggtttg
540 3692317 — NO acaatgtggctgtgtttgatcccgcgacgtgtcacttggaatctcaatttattgccaatagacgacgttgtcaggcactaattttctggtggcgctccatc
541 3749798 MGC33894 NO tcgggggtcacaagccaaagccacaccgctagaagggctcaggacccagcccagctcccgtcctcttggtggcatcaagcttgtgtgatatgaggtcttat
gtc
542 3965785 MAPK11 NO atggagctgatccagtaacctcggagacgggaccctgcccagagctgagttgggggtgtggctctgccctggaaagggggtgacctcttgcctcgaggg
gcccagggaagcctgggtgtcaagtgcctgcaccaggggtgcacaata
543 4051547 LOC100129722 NO tgaccttggcccagaatccaccagggcagggcctgtgaacagggccaacttggggccctcctccgccctctctggatgcctccccttcagcactgggcct
gccaggcagacagatggacacgtgcttgaggaaacacgggttttatctgggcgaggggttcacgcctgtgctccggggcccctgcccaggttgtgccgg
gttcagagttgactggctgccagtggaacagagtgtactttgctaatgaagcccttgtcattggacagataggctcctccaggtcctccctgccctgtaataaa
cgttgccaccg
544 2849256 — NO aagacaggctggtgctttcaaaatcagtattttattgtgaggtcaagcagaaatgtactagcagcacaaccacagatgacacttgtttggcttaaaacaagaca
caca
545 3166772 — NO tttcttgtctcttgagtggcggatcatgcgacacctcccgaccacagcatttgggcgagatatagacatgcctctaaa
546 3886907 PIGT YES acaacgagacattagaggtgcacccacccccgaccactacatatcaggacgtcatcctaggcactcggaagacctatgccatctatgacttgcttgacaccg
547 2474079 — NO agggcacagagagttcaacaaacactgaaacttaagtttgtcctggacatcttcagcatccgactttctggtggaaag
548 2661946 — NO gccatcttcctatcctggtcctgat
549 2963039 — NO ttggtctctatctgggcacagtctctttggtactgtgtgttaggactagatgtttttaacatgaatgaaaacgtggactcaaaagaaacacttttcaggtgtctataa
atcttcttattttcaagtttacttagtatttggtcctggggtgtctacatgtcactcagttttgaggaaaaaatgagatgaccttagaaataacatagaaattaatgtg
attgatgaatatccttagaaatttaatgagatttatacttggaatatggcaattacaatattttattgaaaaatgaataggtcaccagcctggcc
550 2991676 TWIST1 NO tgaatgcatttagacaccggatctatttgcattttaccatgggtcctcaataaataaatagaatgttgttttttgtattttaagtttttttttgtttttcccctcagaggaag
gatgaaaaaaagaattaactgactatggttttgcaggccagtttgatcccagtatttttatttctaaaggtgttcttatagttcctctgattgttaccattttaaaatag
agaaagtccatagtgatgcctttcctttcagtggctgattggcacgacctcttgaga
551 3535849 — NO ctgaatgctacaacctcggagagagaataggggagtgttggtgtttgtggtgaatcggaaagcacgtgtttaaagaggacaatcacattaattcagttccagc
tatgagattacattgtcaaatcatctgatttttcaagagaaatcacaaatttgaatttcttaaaatgagaaatctactttttaaataatgacgggattttcaagtatgtta
aaaatactgtaggctaataccgaataagctaagcaaaacttttgtggatcaaaccgaaaccatgggctattttcttctcctcctcttcctcctccttctcataggaa
taaaacaactaaatataatcctgtctttataatttccatataccaagctttaattatatttaatacccatcaaagttagttaaaatgaactctgagtaatttataccttat
ggaaaaattacggtgttctaagtctgaccaaatgtgtagaaagtacc
552 2488753 CCT7 YES agccagctatggtgcggatcaatgcgctgacagcagcctctgaggctgcgtgcctgatcgtgtctgtagatgaaaccatcaagaacccccgctcgactgtg
gatgctcccacag
553 2575232 SAP130 YES gtgatgtccagttctaaagtaaccacagtcctgaggccgacctcacagctgccaaatgctgctactgctcagccagcagtacagcacatcattcaccaac
554 3076375 BRAF YES cacgccaagtcaatcatccacagagac
555 3187656 CEP110 YES aatttgcagcagatatcccagcagcagaaaggggaaatagagtggcagaagcagctccttgagagggataaacgagaaatagaacgaatgactgctgag
tcccgagctttacaatcgtgtgttga
556 3286398 ZNF32 YES actgaagcccaccacaaatatgaccactct
557 3840338 ZNF808 NO acagatgtcggccactttcgccatcctgttttttgt
558 4019888 — NO ggaacagagtgtgccagaaccctcagggtgtttctcagctcttgtttacgggccaccag
559 3831504 — NO tggtttgcgaatatgctcaagtctctggatgaattgtatgacagtgaaggggtatgtgattagactgttgtggctttgaggttgatgtgtatgttttaaaggattatg
attgagttggagatca
560 2540638 — NO ctccttctatcccaatcggacagtgatatgaccctggggatgttccatgaatcatttgttcctctttggccccatctgattgtgtacttatctccttacacagtccttc
tgaccttgaaatgatccagaaaagatgtaaaagagtaaattctatagtcagtttaaaaggcagcaggaaaggattgggaagcattttggacaaggggtctag
gagacaggcccagctctgcacttttccgtgggacaaaggcctttgcattctctcctgta
561 3229612 UBAC1 YES acgaggatgagcgtgtggacgaggctgccctgcggcagctcacggagatgggctttccggagaacagagc
562 3839570 KLK2 YES ctcatccagtctcggattgtgggaggctgggagtgtgagaagcattcccaaccctggcaggtggctgtgtacagtcatggatgggcacactgtgggggtgt
cctggtgcacccccagtgggtgctcacagctgcccattgcctaaagaa
563 2380069 KCTD3 YES ggcagcaagtgtttacgagcccatatttggattggactatcgaacgagtagctttaaatgcaaaggtggttggagggccacatggagacaaagacaaaatg
gttgctgttgcctcagagagtagcatcatcttg
564 3428646 MYBPC1 YES tctgattgacaagacgaagttcaccatcacaggtctgccaac
565 2998434 RALA NO agtaactgtccgctagaagtctgtccaaatttaaaatgtgtgccatattctggttcttgaaaataagattccagagctctttgatcgcttttaataaactgcaagttc
attttaaatgaagggccagcatatatacttgcaagataattttcagctgcaaggattcagcaccagttatgtttgaatgaaccctccttttctctgagattctggtcc
ctggaaatccctttctgctagtggtgagcatgtaagtgttaagtttttaatctgggagcagggcataggaagaaaatgtcagtagtgctaatgcattttgcacta
gaacgcttcgggaaaatattcatgcttgccatctgttcatttctaaatttatattcataaagttacagtttgatacaggaattattaggagtaattcttttctgtttctgtt
tataatgaagaacactgtagctacattttcagaagttaacatcaagccatcaaacctgggtatagtgcagaaaacgtggcacacactgaccacacattaggct
gtgtcaccattgtgtggtgtacctgctggaagaattctagcatgctacttggggacataatttcagtgggaaatatgccactgaccgattttttttttttcctctttgc
agtggggctaggacagttgattcaacaaagtatttttttcttttttctcagtcctaatttgaacaggtcaaagatgtgttcaggcattccaggtaacaggtgtgtatg
taaagttaaaaataggctttttaggaactcactctttagatatttacatccagcttctcatgttaaatatttgtccttaaagggtttgagatgtacatctttcatttcgtat
ttctcataggctatgccatgtgcggaattcaagttacc
566 3544955 — NO gctttctcctcttccgggtcttggactg
567 2981913 EZR NO cagctaagatgccatgtgcaggtggattccatgccgcagacatgaaat
568 3013230 CASD1 NO agactgtctgcacctgtattcattgtggaacttcctctttcattggaaactttcttactcaagaatgacggcagtattgttttcttatatgtgcaatgaagtggaatga
taaacagtatgcctttaatttatatgtgttcttgttctgatgttgtttcctgaaatgatttttcttcctaactgtggttttcgggtatgcaagcctaaatctttgtacactttg
tctcacagaatagttctgaggctccatgacagggttttgtcattgttgatgttattgttgcttcgttttataaaaaagccaaaattttttttccaatccaaacgttcacct
gtttcctttcctcaagctataccagtgtaataccagttaccctgtggatccatttaa
569 3739279 — NO gtggcagtatctgtgacgatgggaagt
570 2409084 — NO agattttttgccactgccttgaggatccctgattcctattgattttacctgcccttggacctgtccacctctatcttcacctccacctccctgatccggtctctaatca
actctcacctggacaacagaaatggcagcccaaattgtctcccacat
571 2848243 — NO tccacaggactagctggcagatctaacgttggggagagagacaaaggtggggtcacaggcagccccagcgtgttggcccaagttactggaagtttggag
ttgccttgggaagtggaagcttgtgtctagcaccttagaccaccgggccatcctgccacacgcttggagttgctttgaactatgctggggaaggtgcaggcg
gagctggctgggaaagtcagcatgggcatgtgaagtttgggtgtacatgacatcaggctggcagtggtgggtgagaaggagtctggggttcgggccaga
gggtgggctggagatgtaggtttgttgggcatccgcacagatggagcctgggagtagctgagactccatggggagcacgaggatgagctgttgaaggca
tgagctctggaccctggcattagaggtctaggaaattaggggcaaccagtaggacttgagaggggagcctggggaggaggaagtgccaggagtgagtt
acactggcggcccagtgaaaccggggttcctggggggcgggatgtgtgtgtgtggcagggctgggttatcttatacctttcagaactatgtttaaagttttgta
gatgtaattagaataggatgagttcatgccactttgaaacctataattgtatgaataattttgaattcattacgcagacatgacacatcacggcttctctttgcgtat
gatatca
572 3775781 — NO tgactgagctgtggaccgcaagcagtggcagccccttggctgctcgctattttgagtctggagagattgttcacgaggagcacaggctgtttggcaacatca
gagct
573 3990538 — NO ctgggtagtctacgagaaatgtcaattattatctctactacaactacttacatatatctaatgggaaaagagtggggcttaggtgtcagagtggatgggagaca
aaggagaagctacactaataaatacaacaagtggaaggtacctgtcccattcctaaaaggatttgtgggcaatgctggcacttggtggccaggagaatcttc
tgaccccactctccctcctcttcagtcctgaagaccccaagaacccagttaggatcccctggccagaggtctctgtgactgcctctggactcagcacgtgca
gcagcttgggaggatttgagccagtctcaaaaacttttagccccagaatgagaccagtgaccccaagcaggagggctgggatctggagggaagagagg
gggtccaaggggaccctgtggctgaggccatggagaaccagtgccagggcccaagagacccatttttccagttatcagaggtgactgacatcttctgcca
ctgccttgagttcagaaatttaaaaaagcttgcagcaagaaaatgccagtgtgcaactgggtgactaaagacca
574 2411004 KIAA0494 NO ggactgacgcgttcccactttcttactctgcacctccccactctcttcccattcaagaacgagtttctcttccctctccattggaaatcttgctccggaggtccgaa
acacgtattttaagcgtgcccttcctcacctcctggagcacccttagaagtattgcctacttatccgggctgagaatccttcatttttgacctggcttttttttcgccc
tttgggagataaaggtccctctccaccctctactaacactctgcacccaaggccttatcctttggggtcaccag
575 2642748 — NO acaggggcgcatttgcctcacaaggaacatttggcaatgtcgggagatattctgggttatacaagtgggagattaggaatgctactggcatctagtgggcag
aggccaggatactgtgaaacatcctataatgcacaggagagctccctacaacaaacaatt
576 2661956 — NO atggacacccactttccatgcttag
577 3307945 — NO aaaatccagtcccaactgcagatccctatgcactcccccaac
578 3789999 — NO ctctcttcttgtggtaggtcccagaaacttctacttgggggtacatgaggcccagctgggattgggcacagaaggtcatggctctgcacctgaccctcacctt
aggggtcaggagagagccaaggacacgagtgatgggttagggaggactcaggcaccatggaatactgtggccatccttccatagaggagaggtacagg
tg
579 3963093 EFCAB6 YES atggcgattataccagactggcttaggtcgcatcctcacacacgaaaatttacacattcaagaccccattcttcaccgtgtagagtatattca
580 3589632 EIF2AK4 YES cagagaagctgacgaggagagaagt
581 3816037 — NO tttccatcacccagcaaacgccgtcccgcagcacccgggaagctgcggagtcgggctggggccgccgcgttgcgcacatcggtccttg
582 3417925 LRP1 YES cggtgaattcctcttgccgagcacaagatgagtttgagtgtgccaatggcgagtgcatcaacttcagcctgacctgcgacggcgtcccccactgcaaggac
aagtccgatgagaagccatc
583 3696235 RBM35B YES acccgctgatgactacaccagtctgatgcctgttggtgacccacctcgcactgtgttacaagcccccaagga
584 3462998 OSBPL8 YES aagaagcttatccaacgccaaccaaagatttgcatcagccatctcttagtccagcaagtcct
585 3962740 TTLL1 YES ctttgaatgctatggctacgacatcatcatcgacgacaagctgaagccctg
586 2681997 — NO cccagagcgagacgactattccatggccctgagcagacaatttctcttttaaaaatggtggccctttaatgatgttattatgaggtttttaaatgacatatcaaaa
gttgtttatatcacaaaaacccaacagtcatttaattatactaatgaaggtctttatacgtgtcagattttttaaaaaagacttctaatggccatgagaaatggactg
ttgctgctgcttgcatcacagcagtggtggcagcattctttgtagaggaagaacatattttataatgtataagggaatttgcatttcgcttttcacggcaaacctttc
tgtgttttttgtaaatctaacaattgcaacaacatggaatatttagttgggagatgtttggagtaagtgttgaaagcaactatgtttgcttgcttttttttttttatggtta
gagaacaactgtggcgactttcacagattgaactagtacagttcaaaggaaaatcatcgactttagcacatctgatagctatataggcatggcagaggtgtctt
gaaaaaac
587 2743344 PHF17 YES ggtcctagaggaatttgagcagcgatgctacgacaatatgaatcatgccatagagactgaggaaggcctggggatcgaatatgatgaagatgttgtctgtga
tgtctgccagtctcctgatggtgaggacggcaatga
588 2992873 — NO ttcccaagcactgtacggggtattgggaaggtaagaacaaaaaagatgtagtccttgcccttacaggtctagttgaggaaagaaagggggattgttttccagt
tgcactgaatatgaatcagaatgaggaagaaagtacttggaagcctctagctgactctggtaccattccacggggccatgatacctttcttagtc
589 3568027 — NO acatattttatgctatgccctgggggtaaagggtgactaagacgtgtaaggcacttgcattctacaggccattgcttttcatgggtataggttttctctccccagtt
agactgtaagccttgttt
590 3830188 FXYD3 NO ctggagacttcctatgtgtgcattggggtggggcttggggcaccatgagaaggttggcgtgccctggaggctgacacagaggctggcactgagcctgctt
gttgggaaaagcccacaggcctgttcccttgtggcttgggacatggcacaggcccgccctctgcctcctcagccatgggaacctcatatgcaatttgggattt
actagtagccaaaaggaatgaaagagagctctaaccagatggaacactggaacattccagtggaccctggaccattccaggaaaactgggacataggatc
gtcccgctatgatggaagtgttcagacagtttataatagtaagcccctgtgaccctctcacttaccccgagacctcactttattacaagatctttccaaataccca
aatgtccctgcaagcccgttaaata
591 4011203 OPHN1 NO tcccaggctcctatgcaagttttttttccccattatatcacacttatctagcaagggaccttgtggtttgtggctttagtggccatcatttctgggggttggcttttac
ccttttttcttgaatatttgccaccaagtgaaaaatgttaggacataaacccttgccaggtccctttcatttgctatctctattattggaaaggacctaaaaattggtgt
aatggggcagaaatctgaggaatggacatttctaattcctgtttgttgaagggaagttgctggaaagagcatcagtacttgtttctatgcagatgcctgggccg
tagcttgtctgtagcgtctgtataattataatgttgcccagtgtgagggaaagagctttcctacttgcactcttctaccaaggccctgttagtgcactgattatagta
ctgacagataaacctagataaagagatagagagtgagtacatgcacactcatgtgcaaacccactcagagatgcatttggaacagtgctactgaaaggcag
tagtcattttcaagactgaattccaaacatggtttattggtgagttaggaacatgtaaggccaagtacactgagagcctttttgaaagtaattgagtggaaacttg
atgccattctaaatcaaggcatatccaggtggcccggttgaactcactccactgtacccagtctcaaaggccaggttgctaagaaaccaggagtaaaagagt
caagtgaccatcatttcacctgctgcttgcccccaatagtagtctctgtgaggccttactgacctcacctaggaagtgatttttgagcccttgtttcagggctgtg
gcctccctgctctatcctgaataaagcagacaggtgtgcagattttggccatgaaagcatggctaatagggccacagtccctttaaagaaacatggtttgact
ctggttttcttgggggaaaataccacaatcaccgatgcaaacattggaagattattgagagccctagaaagctgct
592 3349796 — NO tgcagaaaaggtggataacccaactctggtggg
593 3040457 TWISTNB NO tgcctcagccattctagttttgttgtgtgttggaggacagtctaatgaagacaggataaatgtgattctgactagtgggaaatttcagattactttttaatgattgga
atgggctataagatattgtgctgaagagaaaacagttgttctgttcactgctttcattgagaaaatgtggaatgtctcttgactaattgacaaagtgtaatgaaatg
acaagctggttgaagctggtaatcaatgcatggccatatttattcattttccacacacttgaccatctactttgtataacacattctgctaaggcccagggataca
atggcaaacaagatagatgtagttccttcccttgtggcatgtcataagagaaacagatgtgcatatacacacaataaataagaaaattaataattgtattaagtg
gtatgaaaaaaagggggaggattgttcactcactgttacctgtgttagtatctgcaaatgcatgaatggttgaactcccatgtcagcatttttgttgccatttattta
gtaccagacatagtgctggtctcacagcttaatatttggtaatgaataaattctgctagtggtatatgttgatctgaacttacaatgatgggatatagaattggcag
agtggcagatgttcacaattgtctacaagtagatgtgctagacaatggaaggatgcaggccaacctctttgattacaattgagattcatgtgactattgagccct
ggaaatgtagcttgtcca
594 3895503 — NO gtggcggaccgtagaagagcaagccca
595 3907654 NCOA5 NO ccaggcccagctagccaagtttggaatggcatttgtcatgtcagtagccaccacctttgttcattgtgaacctaccaaggctttccagcttcatacacattgacc
agagctcaagctcctgcctgcaactcctgcctagagttgaagaaaagcaaactggccttggcaggcacagtgtcatcataccctcaccccatatgtttgggg
tctgcttgaggattcataaatcagccactctggattgttgaggaatggccatggcagccacagaaaaaagaatttttctctctgagccaaggttgttttttgtttttt
tctcttttcttttttgttttcatttcattggaagatctccaatggactgaacagctccagtcagcagcagttaccacaaactgtgaatctgggccccaccactcttcc
ctgttaaccagttctgtcagcatccccctctccagcagcacttccatgaagttggttctgagactctggccgtgaacacccgtttcttcagtgatttgttttgggct
tttggctcaaaaccccaggctcttgtttttgtctagactcttattctgtttcctgagcagcaggaggtagggaccactttgatgtcagacttctggtagctggacat
gttctcgagatgggtggctgttcgcgacttttgtaccagagtgaaattgttagaaggagggtttctggctgtggttctaaatggagccccaggaagctgccctc
tccccagggtttgtgctcagtagagcc
596 3679982 — NO aagagacacttttccctaagcaggaagttaataattaagttaaccaagaaatagaagtgcatgagtattgtttggaaatatggagaagggaagaagagtaga
aacagctgaaaagattaaaagtgattgctttggcgaggt
597 2858366 — NO agctacacaggaaataacaccaccaaaaataacacattcaaactcagagggcaatcttccctaa
598 3048215 MRPS24 YES accatgccgcagagcgaacggtggaggatgttttccttcgcaagttcatgtggggtaccttcccaggctgcctggctgaccagctggttttaaagcgccggg
gtaaccagttggagatctgtgccgtggtcctgaggcagttgtctccacac
599 3168775 — NO atctgtagccgtagtaaattttggaagggcaaatcaatatggcgggtagaggctagttggtgaagcttattaacacagattcttttccaggctaaagttgtcttca
gtggttaacctttgtttctcctagtagagaggtgggcaggataccttttgtctttgcaaatctatgtcttgatttaggcaagtggaaggcagagaggtttcttgcat
ctgctccttcaaaactaccttcagta
600 3643388 — NO ggaggtattactgagcgccacctggctg
601 2927513 TNFAIP3 YES gtgacggcaattgcctcatgcatgccacttctcagtacatgtggggcgttcaggacacagacttggtactgaggaaggcgctgttcagcacgctcaaggaa
acagacacacgcaactttaaattccgctggcaactggagtctctcaaatctc
602 3911005 — NO atgcctgagggcatcgaccagaacgaaccagacacgagtccctgccctctggaagctcacgttccagcagaggagagg
603 3942797 INPP5J YES ttcatcctgggctactatagtcacaaccacagcatcctcatcggcatcactgaaccctt
604 2802457 — NO ggcctatggtaggattgtaggcataagtgctggatcaggagtcatccctcttctacctctgctgccttctgatgtttcttttgccaaccagcacgccggaccagc
ccttcttgttttctcttttggttctaggtcacaactctttctc
605 2874851 RAPGEF6 YES caacacctgagcgtctcataatgcatttaatagaagaacattccatcgtggatccaacttatatagaagattttctattaacttacag
606 3147604 AZIN1 YES gaaattggctttacgatgaacatgttagacattggtggaggattcacgggaactgaatttca
607 3822303 CCDC130 YES tgccatataacatctggtgcgatggctgcaagaaccacatcggcatgg
608 2767313 — NO ctgtctttggattgatggctcagagaagatggcagcatagatctttaaagcagtttgagtggggaattcttggatcttggggtacttggccatgtggacaggatt
ggctggagaaggagggtcaggtggcggtcctgctgccaaggtctgagggtaatactgctcctaag
609 3159245 — NO tgtgtgtctcaaacttcaagaagtctctaggataacccaaaggcaacaagggagaccaaaacaaggacgctggagacattttagcctctgatactgacagct
gcagcaaacagaaaacgcagcctaaccgcgggccagataaaaacctcaca
610 3403122 PTPN6 YES gaagcagcggtcagcagacaaggaga
611 3849599 — NO tgggcacccgttatcctagttactcgggcggctgaggcaggacaattgcttacccagaggccg
612 3534950 KLHDC2 YES tgcctatgatcaccttgcatggacagcaatcctgtaaacatcacagagtggcatcatttgtataattatatgcattgttgtagtttgcacctgttggttttaatgtgca
tgtgaatggcctagagaacc
613 3631427 — NO ccctgttttgatatcctggttgtgaaatgtcttatgttttctgctaatctatttgtgttaaagtaagcagggttggtttacagtaccgtggctcaaaagctagtgtagg
cagctttcctctcctg
614 3779594 — NO acgccaagagtccagtgcaacgatccctgccacacggtcagccgaccccacttggtgccacagggtccagcctcggccactctgggctcaacctttccag
cacgtctgggagcccaatgaggctatgggacagtgtgcatttccctcaaggcctccggaaagtcacctgccacccactgtgacctctgaggctgaaagga
ctaaggactcctttccccatcatttcagctgggccagtggctggctaaaatcagcgcagcattcccattcttctgaaagccacagctgaaataatgcaccagct
gaaaccacagtggacagactgagatggcctccctctgggcctctagttggcaactttctcacccgggggctcctctttctccttttcccgctccttgttccagtc
cttaaggccttctggaagtgaggtgtcctcatccaagctgccagtgccttccacaaattcttcataggtagatttttccgcaaatggtctggggcccaaaa
615 3931281 — NO cccgaggagcttgtgatgtcaccagtgtgccctgcgggatctggggaacaggagaagtaggccagagaagtcgggttgaaaggtgtgtcgtttgcgtcct
ggatctcccttaatttaaccccataacattccattttacagataaggagactgatgctcactaagacactaatatgcccactcacacagcaagtcccaagtctct
ccccaaaatgatttgagaattttgaggcacacaaaagggagaaaattgagtgcccgtgatccaacgactgcaactgtaggaaaccaggaaagtggagga
gtggtagtacttctgaacccta
616 3110077 — NO tgggaagaggattcggactcgtcacactgcagagcagcagagcgagaaaggatgagaagaggcagagaaggcgacggcagaagaaaaaaggaaaa
actgcggccgcgatcagagcctga
617 3419463 — NO gcgccctcgccctgggaaactcactggagtggggacagatctcaggcgtttggcagtcac
618 3903370 — NO attgtatttctattggacgctgctgctctaggttactgagttt
619 3609638 — NO agaatcaggaaaattggtgcagggattggcacactgcagggagaatgcatgggctccatg
620 3227685 — NO tcttgggtactcaccttcagccctagagcattctttagcactcacagtttctcttctcgtcgggttattctttatattaatcttttcctgtccaaattactctctatgtctcc
tgatcagtccttgactggaagcatcaag
621 3349840 — NO cataacctctagagtagaaagtttcagaaggaagagattccccaaactgtgtaattcccttgtaaatctcattcattcaatgggatttgagaaccaaccacttgtg
caggtgcccgcatccgaagataacttgcccccaggagacagcagataagaagagggcagagacaaaggaggtctttttgcgacttgcatc
622 3035683 FTSJ2 NO cccatgtgtgccttgacgggacttcatcttatagactgttaaactgtcacacacaaacaggctttccacccctgctctgagagcaccacgcacagatttccagt
tcttagtgtggctgtttaaagtagaaaatctgggggctgggtgaggccactcatgcctgtaaacccagggctttagaaggctgaggctgggggattgcttga
agtcaggagttcaagaccaacctgggcaacatagcaacaccccccatgtctacaaaaatgaaaaaccaaaaagcaaaccaaaagaaaaatctgaaatttc
catctggggattaacttctgtctttctggtgaacaatatagcaattcacgcattcttcaagcagcaaaagttcccggaacaattagggaagacgtatggtctgaa
tttatccaggcagtgggtctgctttggtttttgctggaaatttatatcagtgtctgggctcccaagaacataaatgtaattgccaaagcaagcagtgatgtggtgt
gtttattttcttttactcatctaggaacttgacgcagcttta
623 3439354 ZNF84 NO tcaagaaagagtcccgattgtgttccagtacctggttcttctggtct
624 2812078 — NO ggcagtgctgtagggagcttcattaattatgatagtctcgctgtgtcaaatggattacaaatggaaccacctgtggggagcctgcaaggttacggacagagg
cta
625 3038635 — NO gatatgaaaaagcacgcatgcaactaactactgttgatctgctttgcta
626 3088092 — NO acaagagggcgggtacaaacgcacagcttccagggctgaaataca
627 3337338 ALDH3B1 YES atgaaggacgagcgtgtgcccaagaacc
628 3420557 — NO gtaagttgcctgtcgctcctctgaatttt
629 3841267 CNOT3 YES atggcggacaagcgcaaactccaag
630 2929962 STXBP5 YES tcaaggagccttgcacagcatattcctggccctggtggcattgaaggcgtaaaaggggcagcatctggagttgttggtgaattagcacgagccaggctggc
actagatgaaagagggcagaaacttggcgatctggaagaaagaactgcggccatgttatcaagtgcagagtc
631 2387074 MTR YES gttgaggattatgcattgaggaagaacatatctgtggctgaggttgagaaatggcttggacccatt
632 3388958 — NO gtaggtgccgaacaccgcgagtctccgcgcccgacccgacctcgtgttcgagtgtgtgcacgctggcgtttatggagagactagaagagccgcccacgtt
aagagtctacgtgccctgcagg
633 3620562 — NO cccaaactgaaacatcatacctatta
634 3870278 — NO gtttgacttctgactaaaggtcttg
635 2833045 RNF14 YES tacctgcaagcggatgaggctaataaaag
636 3030300 CUL1 NO gattgctgcactggacgactttagaacatccctcaca
637 3767510 — NO agatcgaggacagtgttgagacaccaccacctc
638 3039444 — NO gttcaaacagtagtttactcctgcctcag
639 3067653 — NO agtatgggagaggggtaatgctgagca
640 3139926 TRAM1 YES aattaacaggcgaatgcacttctccaaaacaaaacacagcaagtttaatgaatctggtcagcttagtgcgttctacctttttgcc
641 3203423 B4GALT1 YES atgtctatatctcgcccaaatgctgtggtcgggaggtgtcgcatgatccgccactcaagaga
642 3875984 — NO tctttctctgggttcatttcctaactgtctaactttggg
643 2848542 — NO atggtgtggcaagttgactgtatcgtgatgttagccgtcttgtggcagaga
644 3134299 — NO agaccacagaaactgggcgggcagcagatgcagacacagccatcctatgcatttag
645 3538031 — NO tgaccacgtgcgcaaattatttttcttttttagtagaatggtgcattttttgcctttgtatttgaaatttagctaaattacaatagctatcagaactacaattgaccttagt
aatttcaaaaccatagttataagggttttaagttgatttttaaaaatcttaagatatgatagggatttcaaaactatgtgtgtgtatctctgatagggaggggttggg
gcacagactaataagtgtgccaaaaatctgtgaatccaaatgtgtaacaagtgttgtctgaataaatgtccacaaatccatgctattattg
646 4037525 — NO tgtattagaatgtaatgaactttaatggaatgtactcgaatggattcgactggaatggaatgttctggaagtgaatggactccaatggaatggattcaaaagga
atggaatcgtacgga
647 2814589 BDP1 YES agcttctgacatctctggaggtttcagcaagaaaagattgtgtaggttccaaagagtctgctttggcaaaaatagatgcggaattagaagaagttggaccatc
aagaagggttggagaggaaactgtaggagataattcaccatcttc
648 2823139 — NO tcccaacctggcagtgctgagtggg
649 3113389 COL14A1 YES ggacagaaccagctacaaccatagtgcctaccac
650 2853728 C5orf42 YES cagcagtgagagtcgtccagtccatggctcgtttcatggctgcctatttcaccaatcagcagctttgcattttgccccctca
651 3895815 RNF24 YES gctcggatttcccacattacaacttcaggatgcctaatattggattccagaatctgcctctcaacatatatattgtggtttttggtactgctatatttgtcttcatcctta
gtttactcttctgttgctac
652 4013748 BRWD3 YES ttgttgatttagattcagacggtcctggtacttcat
653 3384440 — NO ttgtccttgggcaaacgtggtatactttctcagtggtggttggaaggaaatttgttgccctgtcatttcgcaagtatggaaaaagacctaaaggagaatttagca
gctgcagccgctgtttttattgcgtactttactagcgccaactctttaataatcgcttgttagttgttacccctgttttatgggtcaagagactcaatatatcagtactt
tggtaaggccaggcagc
654 4026568 FAM58A NO aggccgggagtgtactgtgtgcagctgacccaaggcagccacatctgcgtttgtcctttgagaggactttgactacaatacaggcatgacatcaatgaaagg
aaagtcatgaaatcgatgagactgaatccctacggatttcttaaaagccagatttgtagggagaatgaatgtgca
655 2675946 WDR51A NO gccagggatttgtaccatgggacttgg
656 2941689 — NO tctccaactgcagcgacctgtggctcttcagat
657 2330052 EIF2C4 YES gaaggcagtcatgtgtcaggacagagcaacggccgggatcctcaggccttggctaaggctgtgcaaatccaccatgatacccagcacacgatgtattttg
658 2726487 OCIAD1 NO cgcagtgaggtctgacgtcatttcc
659 2902605 LY6G6D YES ccccagtgaccttgattcaccaacatccagcctgcgtcgcag
660 2732332 — NO tcaaaagatttggagtctagagggcagaaattgaagaggttggtgctctgcacgtctgagtccgcccacagactgaataaat
661 2329455 — NO ttcctggatcacaaagggctgtaggggttccagagatgctggagctctggtacaacaggagggccacaggc
662 2373856 PTPRC YES gtatttgtggcttaaactcttggcatt
663 2465069 SMYD3 YES aaaaagcttggccagaccacaagcgggaatgcaaatgccttaaaagctgcaaacccagatatcctccagactccgttcgacttcttggca
664 3046899 VPS41 YES tgatggcagctgaaattagccaaaa
665 3418387 GEFT YES ttgccgctttgcactgacctccagagggccagagggtgggatccagcgctatgtcctgcaggctgcagaccctgctatcagtcaggcctggatcaagcatg
tggctcagatcttggagagccaacgggacttcc
666 3568670 — NO ttcttgcagtagtgcgtgagctctcactcttgctctggggagtctggattagtccttgagggaatggattagttcctgcaagggtaggctgttataaagccagga
tgctctcaggctctcctctgtttgcatgggttggcttcc
667 2824307 — NO aggcacaggctcaattagtttttcaaactctagccaaggcagtatttcatttgggaaatcatgcaacagaactgctcaattcttaacttctcctgctgttaacattta
cacttagactgccagcaacagttaacttaaattttggtctcaagggaacaaaaaaaaattgcattcagaatttaatatagtattttaaaactaattttagcctgtaag
tcattatgagcaatagtaacttttgtacctcctcatcttgtctgataatatattctatatgctgtcaatctgattatatagtctatatgctagaagttgctgattttcattct
gccaccaagaaaactgtacttttatttatgggaaaaggatttaaatactcctagatacttaaaatttttttaatctaaaagttgattttctcccaagaacaattttgtttg
ctttctacaaagttttaagtttaataaaatgccggtaatcaccactgttttcctccccaaaataaatgctctgatccatattatattagagtgatactgtcacttagtat
tgatatctttaatattttttacatcatgagacattgttatgatcttacctgattgttatctcaaggtgagctaatcatctttatttgccttaaaaaatactgtactggctgg
atatttaatcttgttagtttagttatacacttgttttagtcgagtttaattcaaaaggactcttaacagtatggtgtaaaactcagattttctagtccagacaaattgctc
tctataacgatttggcagatcaatggagacatccgttttaactttactgttctgtacttactatgtagtcatgtgcagcttatcaacacaaagaatacggatgaggg
catttaaatggactacaagtgactctgacttgtaaactagggaagcctcttgtgtttgaccttaaaggccagagaaaaactgaagatagattgacttaactattg
ccaagcagattatgggttactttatacttcctttcattc
668 3204568 — NO agccctcaggccctaccaaccttgactgtcctgtccc
669 3410647 — NO cccaggagtactagttgagggccaggctgctgagaagcagttgaagtagccttgaagcaaggatgggagattgctgggtgagatcaaagatacgctggg
atgggggtgagtgaaagtgtgagcaatgagtagaggcaagattgtagatgctgcatttggaggaatatttctgactgcataatcagaggtcagaatggctag
agaaattaatacagaggtacaaggctagatttagaagagtaagctaagaacagactgcaatgggcttttgaatg
670 2555029 — NO catccacgtacacatatgagctgtacacatagatgttaatcaggttgcttttttcattttatttaaatattcaaaatattgtgtgattgtgatccattgagatcattgaag
tagtattaatttagctgggaattagcagcttatgttgtgtgggcccagttcatcaatatgtgtgtcaaatatccaccctcagatatcagcagcctttgacttgcagt
caga
671 3238290 MLLT10 YES tagtaccttaattggcctcccttca
672 3490689 — NO tatagaggaaacctatcagggcagggacagt
673 3571835 — YES catccatggattgggcccactactcatagcagctcctgaggcaggtaaatggggcaaggactcacgccaaataccacacgcgtatgtcaaacacccaagg
tcggattctggggcccctgccctcaggaggctgtcagactgttccccctaaacacacttctgaaggttgtagggaccttgccctgctgtct
674 2318698 PER3 YES ggggcacccgttcattacttcgagaagcagctcacccttgcagttaaacttacttcaggaagagatgcccagaccctctgaatctccagatcagatgagaag
gaacacgtgcccacaaactgagta
675 2330382 — NO tggcccagctacatttgcaatgatgtgcacgtaaacactgttaagaggttaaagcttgtatacaatctgttactgtgaaataactaaattgggctttaaaaaaatct
tagtatttattgatcttcattcacatatacagttgaaatttaaaataacagatggttattccaatgctgctgaaaccttttctaaaaaatacttgttttgttggttgaatgt
gatgagaggcgcttctgggcagtctctcttctctcccacccgtctttcctcctccgagtaccccttctccagctttgtactagccatgtaaaacccaaggttttctt
taaaacatcagaagagatctcgtcctccatgccccaaaaaagccaactcattggaggtgttaccc
676 3837059 GRLF1 NO ttgggtgttgaagtggaatcgtttcatcccagcc
677 2582942 — NO tcaatcaggtcaaccacaggtcatatgaaaccatcttcccaactcccccacctccactggttctgaagagtgggtgtaaacaatgggttaaacaatccaggat
gcagacagctgttaatcataactggctccaca
678 2876012 — NO tgtctcatctaccaattcctgctattataagatcaacttctgcaaaaaccttatccacctcaagtatccttagcagc
679 3372066 NUP160 YES ctttgccttaacttccacggatatctgggccctgtggcatgatgctgagaaccaaacagtagtgaaatacatcaactttga
680 3781765 C18orf8 YES gagatgcctcataaatttgtgatagccgtgctgatggaatacattcgttctcttaaccagtttcagattgcagtacag
681 3278980 DCLRE1C YES ctggatcacaggtgcataccgccatgcc
682 3435777 C12orf65 NO gttcaagtgcaatgacacacgcctataatcccagcaccttgggaggctaagacaggaagatcacctgagcccaggagctcaagattgcagtgagctatga
acaccactgcactccacctgtccacttgttcttgtgtgacagaacaagaccctgtctctaaaaaataagataaaaccataaagaaacacagtcagtactataca
agaataatggctacttctagagggaaggagttgtcattgtgatgaggcacttggaggggttctggggtgcctgacaaagttctgtttcttcacctgggtggtag
ttagaagggtgtccccgtatttcaaattgtacctttgtgagattgtatg
683 3524572 EFNB2 NO gctaggctgtctgcgaagaaggctaggagttcatagaagggagtggggc
684 3790001 — NO cagaacaagtgcatctgctggcagccagcttaaggagttagcagccctcaattccaataacgaacgtgtaaatcagaattc
685 3301881 TM9SF3 YES gaaggagatggataaagcagatgtttattggggcattccttatcccagctatggtgtgtggcactgccttcttcatcaatttcatagccatttattaccatgcttca
agagccat
686 2745373 LOC100130178 NO tggcagattatgtggaccatcaacaaactaccaaaa
687 2774241 — NO tgcacagacaattccctttactaggtgtcaccatagctaccatcttcatctccttcaaatgttgctttggcattgaggcttaccctcacttccttatttaaaattacaa
ccagctgggcgtggtggttcacatctgtaatcccagcaattttggaggccaaggtgggcagatcccttgagctcaggagttagagaccagcctgggcaaca
tggcaaaaccccatctctataaaaaatacagaaaaaacttagctgggtaatggtggcacacacctgtagtcccagctattcgggaggctgagacgggagaa
tcgcttgagcccaggagatccaagctgcggtgagtc
688 2852754 AMACR YES tacgacttacaggacagcagatggggaattcatggctgttggagcaatagaaccccagttctacgagctgctgatcaa
689 2390973 — NO tttgccagtagcctcataatgagcgtgaggtagtatctcattgtagtgttaatttgcatttacctaacaattcgtgatgtggagcatcttttcatgggcttgttggctg
ctgtgtctcttctttggagaagtgtctgttgaagttgtttgacattttttaatcaagttgttggacaggttcccttgtttttaagtcagagtaggtgatgtttgtcttgaa
ggttata
690 3457600 ANKRD52 YES accaagagaggcgaactccattgcatgctgctgcctacgtaggcgatgtccc
691 2853708 C5orf42 YES ccttattccagggatgctgacattccatttctaactagtttttctggaaagcttagagaacatgaacttaattctttactttttgatgtacatacaacattaaaacgac
atcagagcaaaactaaaagccagaatgtgtttagagctggttcttgctttgttgttgctcctgagtcctatgaatcagaaaaatcatcctctttaaatgatgaatat
ggcatgcatttagaaaaccagaaactttcatcatcagtactggttaatcaagggatca
692 3055843 — NO cccagatggagacacccatagcagggcgccggatccaatctcttcctctcctccctcggccttcctctccccacaaaccccagggtctagaaagtagaagg
ttctcccctcttctctccttcctcataatgaactcgatgg
693 3139045 ARFGEF1 NO catggtttgcggaggttagatttactggaaatgtattcatactgtgaattgtgctctgatggttaaaagacaagattgtcaagcattccgtattaacagtggatgta
gaaaattttttcagatggacaaaatgtatatggtacagatgtaaagttttctatgtaaaaaattctgtacaactttctgtacaatattgattcccatctggca
694 3607791 WDR93 YES ctgcctatttgcaatgccaccggaagtcaagggccc
695 2666907 SLC4A7 YES accaagaaagaaatacgtggatgctga
696 3887309 — NO ccagcagggggttcccatccttcct
697 2333654 DPH2 YES tggaagacgagggattgccatcgcctatgaggatgagg
698 3333566 LOC751071 NO gtctgcggacgctgtataccctcctccac
699 3278417 FRMD4A YES aagccagagaagctcgacaccgtcaagtgaaattggagccaccc
700 3986088 NRK NO tcgacacggagcacccttctagcttcttcgtctccaggactgacgctcaggctcctctctcgccttagcccaacttgctttcccgcctcgcaaactccgg
701 2558398 LOC100128333 NO tgcccaccagccaactagacagatgtggcctgcattgtccccctggaggcaaaggatgtgtgggtatttatttatttaagatagtaagttatggccaggtgtgg
tggctcacgcctgtaatcccagcactttgggaggccgaggcgggtggatcacctgaagccaggagtttgagaccagcctggccaacatggtaaaccctgc
ctccactaaaaaatacaaaaattagctgggcatggtggtgcatgcctgtaatcccagctactcgggaggctgaggcaggagaatcgcttgaacccaggag
gcggaggttgcagtgagccaagatcgtgccactgcactccagcctgggcaacagagcaagactccatctctaaaataaataaataaataaataaataaata
aataagacaataaattatataagcagtgctgaatacagcttcatcatttaaaaatccaaacagtttggaaatatatagacaagtatataaatgctcttcttgcaccc
cttcccccatcctaaagcctaccatacaggtaggcactgttaattatttggtggaaatgtttacactttttgctttgcatttacacatgtgagtggcagggatagtat
ctgagaaattaatttttttctctcctgaattttctctttttctgccctcacatttatggagctcattacctccagagcagcttttcaggttagaaaactgaatttatcttca
ggcatctctggcttttgtgtgctgaaagcttaagcatttagggcaactccaggatttgctgagtggctcatcaaaggatgaggattctcttgcacagactgaa
702 2830633 — NO gcattgtgtatgctgaagccatcatcactctcgctcacaggaggttcattatccatttctgacaagtagccttctccttgatcctcttccttaggc
703 2546259 — NO tatacccacatcactaagctgggaggcacattt
704 3615631 TJP1 YES ttccgtgttgtggataccttgtacaatggaaaactgggctcttggcttgctattcgaattggtaaaaatcataaggaggtagaacgaggcatc
705 3729022 GDPD1 YES gagctcccaccttaccttggcaaactggatgtctcatttcaaa
706 3729073 YPEL2 NO tgatggcctcttgtcaggagagcagtggcacgggggcgtgaggaagagggaaaggggaaactctaagggtcctggcgcggggaaggggtggaaggg
tggaggtaggaacaaaattgcgccgctcctggagacctgataacttaggcttgaaataattgacttgtctaaaagga
707 3043777 — NO tgcactacatcgctggcaagaattgttcagaaaggctggcctgctaacgacttctggggagattttc
708 3080463 — NO aaggcacctacacaacatcaggccacttgg
709 2969705 REV3L NO ttgctaataaatgtaggccggaggggatggcttagtggtctaagcatcagatttgaaatacctagagtccctggaactgcaggtttgaatgtcagcagagtca
acccagc
710 2904894 MAPK14 YES attctggattttggactggctcggcacacagatgatgaaatgacaggctacgtggccactaggtggtacagggctcc
711 3421016 — NO atgcctccagtatcggatatgtgggcaggcacaa
712 3724753 NPEPPS YES tgggttttatcggacccagtacagctctgccatgctggaaagtttattaccaggcattcgtgacctttctctgccccctgtggatcgacttggattacagaatg
713 2600045 GLB1L YES tgttgtggagcgaaatatgagagacaaactatttttgacggggaaactggggtccaaactggatatcttggtggagaacatggggaggctcagctttgggtc
taaca
714 2893581 — NO tgcatttcagcttggagtgcgcagcatgaggcatttgtggttcagaaaagaggtcttcctttttcctcctcctgttttcttttccttccttctccccaactccccaaag
gcttactgcctttcttctcaggccacgtgtgtagataacctttgaggaaaagatggtttccgtgctgggatatttggatattacctaaagggacaagatgagccc
tttctttgccttgttttctttctctggcctcatcagagtgaattatatctgactgtgtgacagttaattgtaccatccatcccgtgtcctaagctgataagccc
715 3712473 MPRIP NO gtgtgtcccatccaagttgagcacgcgccttccccagcttgcagcagcacaccccaagcgctgcttttcacctgtacctttgttttattattattattattattgctgt
tgttgtcatcgttaactgtgggcatggaa
716 3026735 — NO ccatgatgtgaaaggtcgggtgatatctgagagctgaaggaggttaagcggatccatgccaggctgacaaggggaacaggtgcctctgccctggactgg
agcctacgcaaccatcttctgctttatctagctgctgtctgtctcctgtctctgcgtgagtgtgtg
717 3603221 IDH3A YES agtcgtgcagagtatcaagctcatcaccgagggggcgagcaagcgcattgctgagtttgcctttgagtatgcccggaacaaccaccggagcaacgtcacg
gcggtgcacaaagccaa
718 3820895 CARM1 YES ccaggtggaccagaccggctccaagtccagtaacctcctggatctgaa
719 3183801 RAD23B YES agaatgagaatttggctgccaattt
720 3420741 CAND1 YES agaaaaaagtgtgaagacccgacagtgttgttttaa
721 2356132 TXNIP YES cctgctatatggatgtcattcctgaagatcaccgattggagagcccaaccactcctctgctagatgacatggatggctctcaagacagccctatctttatgtatg
cccctgagttcaagttcatgccaccaccgacttatactg
722 2625835 SLMAP YES ctttcaaagagtggcggggactgcacttttattcatcaat
723 2996070 AVL9 YES gtctgtcacctcgagatcttgtccttcatttt
724 3175548 — NO cctcaatgggaaccctggtgcagaa
725 3810034 — NO tagctgttcaggaaagctgtgtggctggagcagagaatatactggaaatcagagaggtcaaaaacaatgagcaggagatatcggaagaaatgttcctaacc
acttcactcttc
726 2767097 — NO agtatttcatgacaactctaagaaggacagcactcaggggcagaatccgcaaatatcacctatttccaattatacttcacatgtgcatatgtgcacacacgacg
gctgtc
727 2853747 — YES ttattctggggaatgcctgaagttaacatttctagcaattcggtggcatgagaatg
728 3016374 — NO cgcagtttgtcagcatcgatgtgggactgggagaggaaggatattgccagttatggttga
729 3845911 LMNB2 NO tttatggcctgggaaacaatttgcatttgtccccaaatacgcttagctgtgtgccgcttagaacgatgcgaaaccatccctctgtgtaagcccgtg
730 2642763 — NO gtggcaggagtattttcaccaaagaaattaaatgctacaaatcctaccaccacaccactggtttgggctcatagaaagtttgttaagagtctgtgacatgaggt
ggcctctaatacagtgagttcaatatttgaacttctgtaaagaaaaggattagatttattcagtatgatcttaaagagggatgctaggggcagcaggtaaaaattt
cagggagacagattttcgttcagtgttgggaaactcctgaggtaagaagtgcccattaggctgggtggccactcaccttagaagagagatactacagagaa
ggctgaaacatggaagattgtaggggttgagtggctcattagtttggccaccaaatc
731 3642784 PDIA2 NO tgtcacccccgccatcactgctggacaggagccacccccttgggtaccagagggagctgtgcattgtgaataaaga
732 3178621 SECISBP2 YES tgttaccgaggttttcaaacagtga
733 3681988 KIAA0430 YES cgatcggtgcagtgaatagcctccacagatacaaaattggcagcaaaaagatcctggtctcacttgccaccggggctgccagcaaatcactctct
734 2973750 — NO ggagcgtgggagttcatattttacactatgttggtacttaccatgcaaatgaacggccctgctgggaaaagaacctttatccagagaggggatccgaggaaa
tagtaagagttgggttccgagaagctgtgctgcatcacgggagagctcggtgtta
735 3284084 EPC1 NO atggtgcggaacctgctgttttatctatttattgtgccgtgtttacagttttttgtacactgtaccttcattggttcctgtgctgtagtaaatgtgttaggtagctgtgga
ctccttggtattttgtaaatggtataacataacttggttcccctctgggtccttgagttttctgtgtatcatgtgaaaaaaaatggtgacatacatacagaattttaca
aaaaaaaaaaaaaaaaaaaaggcatcagtttttttaaaaatggggaatgtactattaaatggggatcttcctggtctactatcattaggacaagtaacaagctaa
aaatgaagtctcttgaatctttccatccccaacttgcccacaaagctgtgggtggtttctggtacttaaagcactaatattatgttgctgctctgcgaacagccca
gtagtcccattt
736 3642301 — NO ccacaggagacacgaggccgaggtggcgcagcacccaccctacacagcagtggccatgtgccaattacacgtgctgggaggag
737 3133236 PLAT YES tgtgtctgaacgatggccgcatgactttggtgggcatcatcagctggggcctgggctgtggacagaaggatgtcccgggtgtgtacaccaaggttaccaac
tacctagactggattcgtgacaacatg
738 2858415 — NO gctggtaataatcgcgtttttggtaaaaacacctcatggaatttttttcctttctcataaaatagctgatactgtaaaattgagatagcctctcaagtctggaacacc
tttcaattcatcaaaaagggacaacctaatattccaaagaagactcaatccttttaacacacatacattttagggccagtcaagagaagtggcctgttctgtagg
aaaacatttcttggcacattattattttaagtgattgcaggagaccacagagggagagaaaagagacaacaacaacttctagcatgcctgggggatgacttgc
tctttcatatttgtggaaccctatgtcaagagagaaaacatctaaaaataaaaacgcatttactcagattctctagggcaaggtgcaa
739 3301253 — NO cttgtggcattgtgctaaagcaaaaaggaatggaatttgcaatgagagagcctttcaagttcaggctcagcctttagctgtgtgaacttgaaccactcacaattt
ttctgaatctcaatttcctcatctgtaaagtttatctaatatgttggtggtgaggtaatcatattattatctcaaataggagattgtatatgaaagggctttggaaagg
caaatcccattatttgtttaaatcaattttttcccctaaaaaagatagctcataaaagaatgtgaacttaatctgtatgtgtaatttctttcaagtcctatctgatgttgct
tgtgac
740 3068212 DOCK4 YES aatgcctgtagtgtccagtaccgacgaccctttggctgtgcagttcttagcatcgctgacctgctaacaggagagacaa
741 3664307 — NO ccagcaattctgaggcagggaccaatcaga
742 2357616 LOC388692 NO atgtggattgtctaactggaggttgggagtccagggtgcagaaggagaagcttggagtgcaggatttggtggtatgtgtgtggcagtaggcactatgttctaa
ttgccag
743 2824047 — NO atgaccagagtcataggtggtgatgt
744 3348756 C11orf1 YES atttaagcgagagcctcactggttcccaggacatcaacctgaactggatcctccccgata
745 3561991 — NO cttatttgatgggtggccaagatactgggtagggtggtgtgatttgctatactgagtagatcagtaaacaataaagtataaatcttgctttgtagttggaaggtca
gttaacaaatatttagtcaatatgatgctggagttggctaatgtatcccccaggtctaattaatgaaaataatcttgcattggtctttaggaaaatcatttttattctctt
tctgaatacttaaccatagttgtttacatgttttactgtggaagtaatatcttttatgaatgttttagagaaaacaattatggttcacttggaccattcagtaatttgtcc
agcctggctagtttctagttatctga
746 3051857 — NO agagaagaatcctccgacggcttcgttaccatcctgtctgaagcggattgcacgagccc
747 3459696 — NO tgagcttcacatggggtcaaactggaaagtatctctttgctatgctcccatttaattaaattaggaaatctgcctaaaacttgaatcactcctcttttcagctggtgg
ccaggcaggaatgctccctgaagagtactctttcaatagacttcagaatgtgttacctgaaaagtgctcatgatgaatcaagacatcactgtgttttccatacttc
tgaagtagagattgtccactaacagcttagggaaagcagagtacccgctcagctgctctttttctggtgtggtcagaccagctgggtcctctgaaacatgaat
ccatagtgcttcctttgttatactatttctgactcagttttctctaaacggctgtaaaatttaactgcctagctgtattttctttctgtggactttatgctctcatatttagg
agaaagaataagagaacaccaacttacatctctgtagctctggatgattattaaggccctggtctaatgcttaaaggtaagcatctgttatctatattcaataaaa
gaggaaaatgaaccccagagagaaatcaagttactttagaatcgcaggctgtcccatgaccctggtgaccatcactgaatta
748 2614179 — NO gtgaagccatcagtgtctacagcttcagctattgcccgtgtgcagatggtgcttaatctctcttgtgccttccagacctgcatt
749 3047613 — NO attaggtgatggtagcggactagccgacggagggcaggcaggggagggggagaggactttacagaaaaggaattctcggtcgagctctgcctggagat
gactggcttacacttactaaacccagcgggtca
750 3677890 CREBBP NO atcaacagccgccatcttgtcgcggacccgaccggggcttcgagcgcgatctactcggcc
751 3177929 DAPK1 YES tgacaattcaagatagtttgcagcatccctgg
752 3211613 TLE1 YES tcctggtcccagacagtctaagaggcacagataaacgcagaaatggacctgaattttccaatgacatcaagaaaaggaaggtggatgataaggactccag
ccacta
753 3452723 RAPGEF3 NO tgtgagaaggtgaagcccataaggcacagaaggagttcagtgagaccagtgacttcaggctcagtgtgggagaccaggggaaggatgggcatgcagg
gggcgggggactaggctgtgggggaggcaggatgcatggaaggtagggaaggctgaggaggtggagccaaagtcggaggtgggagaagggctgtg
ggtccctgtgggaccctcatggggctcaggggctggaatgaaggaggtagatgagagggtctaaagctggaacatcatgagttgagcatgggatg
754 2845333 — NO ggggctaacatggacggtcaggagctacgt
755 2852760 — NO tgaatgcctgaatctcaaacttgtacttcatcatggactccagtcttcctttcacatccaatttcaatgatcatcaatacagtcattttgctccttagcccactcggac
tatttctctccatacctgctgcaactgccttgacactggtgtgacagccttttaaaaactggtgtttggggctggtatcactccagtggattc
756 2750640 — NO caataagatagacggaaatataatatttaaggttagagaagaaggctgagtgtggtggctcactcctgtaatcccagcactttgggaggctgaggcaggaca
atcacttgagctggggagtttgagaccactcagactcacttgagacca
757 2807722 — NO ttcttatgcaaacaacaccatctgggctctggaacttcacaaaaggacactgttaagtcacac
758 3338718 — NO tcatccatcaggctgtgtcagacgcacctgagccctc
759 3482760 — NO tgaccccagacctagggttgctggtgga
760 3884900 — NO tgcttcgattgctttcgagtcatgagttggtg
761 3038653 — NO aaatgtgggcccgttaaagagcaagactctagaaaggaatctagccaaagaggacagcgttggtgggatggggataa
762 3340340 RNF169 YES agtcagagctgtagtgacacagcccaggaaagagcgaagagcagagtcagagcagttccaggcaacaaagccaag
763 3441973 — NO agtgctgtctacacgctgagtattaaatcctaaatgtgtatattagctgacaacctctcccttgaactctgcactcacataaccaacaatctaaacctctccctcc
catatgctaccccatctcagtaaatggcaacttcattcttctagttgctcaagtcaaa
764 3629351 SPG21 NO acccggtgtgttcttgtatagtcagtggcatcagcacccgtcagccggccttttccttcaggttcgtcaggctcaccg
765 2611420 — NO gtgctggcaccatcgagccacaactcaggggcctcatc
766 3371610 — NO acagttttgagacaggtggttcaggtg
767 3795789 — NO gcctggctcttccttaccacccggattttgtttttgctttctgggtagagctctgatgttgccaaacagcctgtgctcctcgtgaacaatctctccagactcaaaat
agcgagcagccaaggggctgccactgcttgcggtccacag
768 3118031 — NO aggaaataactttacatgtgctcctct
769 2976043 IL20RA NO tcctgtgcaaacaagtgagtcacccctttgatcccagccataaagtacctgggatgaaagaagttttttccagtttgtcagtgtctgtgagaattacttatttctttt
ctctattctcatagcacgtgtgtgattggttcatgcatgtaggtctcttaacaatgatggtgggcctctggagtccaggggctggccggttgttctatgcagaga
770 3330211 — NO attactgaaagtggcgtgcactgaca
771 2397801 — NO atgccagagactgtgatgttggaaa
772 2537317 TMEM18 YES aatacatcaatgaggcggctgcgat
773 2875953 — NO caatagtgcaatatcacgaccaggatattaacattggtacagtcaaaatacggggcattaccatcaccacaaggatatctcatattgcccttataaagccaccc
cacttccctcctacctcacccctcctgaactcctggtaaccacaaattatccatttgtataagttggtaattttgagaatcttacataaatggaataatacagtatgt
aacttttgggattgactttttttcacttagcataattctctgaagattcacctaggttgttacatgtgtcaatagtttgttcctttttaaattttaacttttattttttcgagagt
aagtcttgcactccaggc
774 2882417 — NO aggaaagcatgagaggtcagcagca
775 3095010 — NO catgcagtacattggatatgatataatttatggtttcttgtttgcagctgtttgtatctttttaatcccaaaccagacaaaattataaacattttatatacaatgttatctt
ggaaaaagttagatgtaaataattcatcttaatctatatttgagaaatctgaggggtattaggaaactcatgagtgaatgaacatatagattggatcaaaggagg
agagtatgagagtagggagaccaggtaaaaaggtatcatagtcatc
776 3450794 KIF21A YES ggatgctcctttaaacagcccaggatcaga
777 3627349 — NO tcttctggctcttccgtgacgcattacaacagcca
778 2360857 FDPS NO gggagcagctgatcaggtttctgac
779 3821204 PRKCSH NO gtgcggtggatactgacctttgctccggcct
780 3665595 FAM65A YES tggaggatgaggacgtgcagactcgagtggctgg
781 2852747 AMACR NO caggcccacggctcaagtgaatttgaatactgcatttacagtgtagagtaacacataacattgtatgcatggaaacatggaggaacagtattacagtgtcctac
cactctaatcaagaaaagaattacagactctgattctacagtgatgattgaattctaaaaatggttatcattagggcttttgatttataaaactttgggtacttatact
aaattatggtagttattctgccttccagtttgcttgatatatttgttgatattaagattcttgacttatattttgaatgggttctagtgaaaaaggaatgatatattcttga
agacatcgatatacatttatttacactcttgattctacaatgtagaaaatgaggaaatgccacaaattgtatggtgataaaagtcacgtgaaacagagtgattggt
tgcatccaggccttttgtcttggtgttcatgatctccctctaagcacattccaaactttagcaacagttatcacactagtaatttgcaaagaaaagtttcacctgtat
tgaatcagaatgccttcaactgaaaaaaacatatccaaaataatgaggaaatgtgaggctcactacgtagagtccagagggacagtcagttttagggagcc
tgtatccagtaactcggggcctgtttc
782 3004680 — YES tggatgagtgtaagggacaccaaggaggt
783 2722233 — NO tgaaattcataaaggcatgtgtgcca
784 2805960 — NO cccagggcattagagtgacctcacaagagtatctcagaatatttaaaaatttgaacacacaaacacaatgaaactcaacatctgtcagacatcacgtgaacta
ctagtgaggtagttcattctttcaacataagattgcactataatccttctgataatttcatatttttgtgagactgggttttccaggccatctgataaaaaatcaagta
ctatatggacaccaacatggagcagaaaatgagggcagcagtgtccaatctcattccaggtg
785 2952396 — NO aggaatggaattaataggttgtggcaatatcaa
786 2612927 — NO caacccaatctacagttgtgggcagtggct
787 2640231 — NO tgcccggcctgcaataagtatttctaaataagatcacattctcagctacaagaatttaggatttcaacatcttttgaggaggactcaatttaacccataagaatact
atgtgggccacacatggtgcttcacatctgttatcccagtatttcgggaagttgaagcaggaggatcattgctcagggcctatggggacaccgggtgcataa
gaccaca
788 3371122 SYT13 NO agcaggaaatggaatatgcgggtcacactg
789 2972930 — NO gctgtgacacaacagtgtggcgatgtcccacagacctgaaa
790 3529011 — NO agcggctgcagcacgtagttggagaaggtgagggcgatgacagcctggttggtggggtagatcaccagcacagcaatcc
791 3670860 LOC100129617 NO gagccagccaccacgttagattttagagtctcctggagcacgtgaaaacaactgaaaaagggtaaccacacatcatttcacttgtgatgtagcttgcctgtctc
cacaccatgcccctgaagaatagtatatcacctacagccccttccccagtcaggaatggaagtgcatgacacatgtgctcctctaccccttccatgctcatgg
cagacatcattaatcaattatagcactctttctgtagagccagagacagcatcacactctttcccctcctgcattccaggccaccactaccaactgaaatcgtgt
tagtaccataatgaatgctatgtaccattctctaccctaagcgattgcaaactgtaaatgaattgttgctgatttctgagcccctcctagatttggggtaaattcattt
cttgttttcagaacacaggggatagggacaccctgtgcagttctttctccaggacaaggagactccccactgggggatggggcggggtttctgccttaatttg
ggcgctcatagtttcaaggaggagctctttctggctttggccagctagaaggaaaggtgccctgtttgttaactttaaaatcactacgggtgtagtgtatggagt
gggctgtgccatgctggagttcagagcaaaggttcttcaggttttcttgcgaaggaccttaacttgtcaatggcagagccacacccccgggacatacttggc
agaggaatgcctcttcaggcacataaacatttttgcatactccatgttagtcaataaaccgtttcataagggttctttgaggacatctgacttcaaagggaaaaa
attcataattcagacaggctctcggggcttcaccatacaacgcctttcttgtatttggttagttttatgggcctggagtgttgaccatgtatta
792 3844568 SHC2 NO ttcctccgcatgagcctctggcatggtccttcctccagctggccccgggctgggcagagcctcctcctgccggggcccctgcccaccccctcctttgcctgg
agtgagggtgttcataccaaagacggaaccatttcgcctttaaagaaaatatatccagaagcagccgctgcctcggagccctggcccttgggtccccctctc
gcctggctggttcggtctaacgccccggagagtcagggctcccaggaccctggggaggaggcggattccgggcctggctgggcttcctcttcccacctg
aggactgggtgcacagttgtctttgaggggggacgcttaaggtgctttggggttctcaggccaggatacatgctggcgctgaagtgcaggcagccttgagg
tcacctgggatctcggggtagccaggctgctccaagacagtggatatcgaggcagtcgtgaggcccctactccacctgggagcaggggaaggacgtggt
tgcctggcctgggctgcgcccagcagcttccccccagtcctgccctcccagctgtcgacccagatgggatgttc
793 2810517 GPBP1 NO cagcttacactgttttgcttgcagagtcatatctttttcgtacaatggaaatcctcaagtccactttgtgcggtctccctctccttcccccaaaaaacaacaacaac
aaaacaaaaaccaaaaaggaaaatgtagcatgttggctaaaactggagcaaagtgcactaaaacaatttcctgaactcacctgttgtactattcaccttttaaa
ccataaattgctctttagccatttgtagtgcagtaaatgttacaggaaaagacttggcacattttcttccaaattttaagaggtgattttcaaaagctttattggggta
tgttgtcagaccagggttttcagagttgatggaaaagagtcttgtgagaaaacttattttgataaattattacacacgcagaaaaactgatcacactgactggat
ctgtccacgacatggaaaa
794 2377968 — NO gtaagacacgttcccagaggcaggac
795 3020324 — NO tatgtaatgagcatgtgcatagtgtgtgtatgtgtttgtatgtgtttgtggggggtaatggtctc
796 3133424 — NO cctgagctggcaggtggcatcccaggctcgtgccaggacccagcagggctggtttccatgggcctgaaaaggcccacatcagaattccagggcatagg
cgaggattact
797 3225212 RPL35 YES cttcctctttccctcggagcgggcg
798 3731955 — NO tggaaccctcaggtgttcgcaggtgt
799 4012443 — NO ggagtaggggtcaactggattttgccagc
800 3145052 KIAA1429 YES ttgatgaccccagaaggagttggccttaccactgccttacgtgttctctgtaatgttgcatgcccaccacctc
801 3542308 — NO gggacggtgcacatgtgcattcacatgtgttttatggatgctacagaggaatatcagaagagaggaagagggccccaaacagcccctttagctctgaaa
802 2385170 — NO atggcaggccccaatgtggcgtgcattgag
803 2617336 CTDSPL NO ggtagaactgcccatgccacaaatatttatttggaaaagtagtcattaaatgaacccactgccttaaatgtcttgaatgttgcagtcaagtgtctgtcatgtgttga
tatccacacagaattaggccctaatgagagccttagaccctcaaccatgcccctttcgttggcatcacagggccttatttggaagagcgggcaaagaggat
ggaaatcataaaatatttcatgggaatcgaacctagggatagtgctccacttctgacgatggagtgaagacacttggcagacttgagccagacacttcaccta
gtagttcctgaaactgtgagcaccactgcactaagccagtgcggagctgttagggacgggcccagctcctgcaccacggacacagaatgtctggagagg
gccagcaggccctctgagggttctggaatctgtgcaccttatttgaccacactccaaaattctgtttttattttaacccttgaatctgctttatgtacataatcaaaat
atctatatctatatctatatctatatctatatatttttaatcatctacatgtaaatgaagcaatagaattctaacataaggccaagaaatgagacgaatgtttggggttt
atgttttttaaggtaaatacgggtattgtttttaattattaccatgtattaaattgtgggctttgaaacctaatgaaacctgttagccacttctctgtgccatatacttcc
catgttaccaaaatacccccaactctttagccaaaagagaaccctgacctcctgagtttccatgctcctttctgtaccaggtttaaatgtagtcttctggagaagt
atttttgacattgagctctgggacaggacaccttgggtttgtggactgcagcccactatgatgttattacttctctggccaggcctccagtggaagtgcacagg
cactcccaatgttgttaatgctctgtcttccatttgttctggaatcctacgtgttggtctgtggttccatgcat
804 2982034 RSPH3 YES catggggaagacacacatcagtctccagaacccgaggatgagcctggtggtcctggagcaatgacagagtcactggaggcctctgaattcctggagcag
agcatgtcacagacacgggagctgcttttagatggaggctacctacaaagaacaaca
805 2335196 — NO gtacaggaatccagctgtgtggagcag
806 3561721 — NO tccagctatacacccgtaacccaacagcggctcaaccctgggcgccaactaccgctgcgtcctccgccgcttttcg
807 2819696 — NO gataatagtagtatggatggcagtggcat
808 3408052 — NO catgatggttgtcttcactctcctactcccaatgattcctagaaaagaaactttaaaacatgtttctacttcccattctgcagtttagtaaaatgatttggttaactctt
aaaactttttgtggaataatgttctgtgaattcaagtatacaaggcaggaggatcacttcaggccaggagttccataccagcttgggcaacatagcaagaccc
cgtctctacaaaaaacaaaaagagaaaaaaaatatataatacttgaggtagttgaattgccgtgatttattgtcaccaatatttttaaatcttatatttattataataat
acacattacatttttataactgggttataacattgattattctcacttattctagatgtgacttatttaaataagtttagaattatatattaaatacaattatattaaaaacat
ttttgcttttatgtaaaacactatttgccatgacattttttgtcacgtaattttgtttttctttgtgtttgaatatgatcaaatacttcccaaaattaaacttacaaatgtatat
caacatattataattcaaaagctgtttttatttgggaaataaataacaatgtgtaaagaccgggaatttgttctcctacctaagcctgatgattaaaagacagtgta
actatgcaggtgttaaacattttctatattcttacagccatctctgttcatatatccatttttaactccacgcccctgtaagcctttgagtttgtgatccctggtgaaga
cagtgacccacattgattttttttttttttaaggtttctctctcttttttgctttttctctcgaatataggacc
809 3628699 HERC1 YES attcagcctcattgggtatctgccctggcttggccagaagagggtccggctacagcctggtcaggagagtctccagaattgttgttggtgggacggatggat
ggatctctgggactgattgaagttgttgatgtgtccaccatgcaccgtcgagaattggagcattgcta
810 3350729 — NO tgcagacgtgcacattcccagtccgtgccccagccgtcctgggtccccttacaagcccgggtctgccacttcacccttgtttttccccatcctccgggtccac
atttcatatgcccctgccctcattcccttatgattccctagctgctggttccagagtcttctgggcttacagtctcccggc
811 3380411 — NO aaagcaaggaaggtattgaagacacaaagtcacatgtgatgggctcaggagccagtgtgaggaagggctgctcatacagcacagtggaggat
812 2377588 — NO cccatagagctcctaaccagatgcaacagtgactgcgtcaccattccccacttttcccaactacgcagtgacaaacctaccagctttacc
813 3219836 — NO tgggagccgtggatgaaattgtgctc
814 2737650 BANK1 YES catcatgaaagcaggaagacatacgggcagagtgcagatg
815 2843633 — NO aggctcgccttctcaatagcgtgtatttggatgagatgagtttcactgtaaagagaaaaagatgttaaaacctcattgtctaaggcccctcatctgagaagtctt
gtctgaccctctagcccagcaggaccaaggtgtggtgcctggtcccagcctgtcctctgctcccctgggctgcagttggcccagttgcctgcctccattagat
acggagttgctctggggctgagatgcccatctcaagtgcattctgtcggaagggttctctgctggaaggcctttggttttagttgggattccatgagctttagcc
caaaggtggcctcccatactagcatattt
816 3478420 — NO ccactgtccacagaccatctggggccctggagggagcgggctgggccagggaggaacaactgggaaggggcagggaagaatcactgaacatcagtgt
gaaggtggcctga
817 2749415 TMEM144 NO agcttttcaagacacttcctgcatctctgacctgttgcacctctgttatcaggcacctctgttatcaagc
818 2921363 — NO tgacgcgggtcttacctgggctaaattcaaggtgctggcaggaatgcattcctttatggaggttttggggtagggggcaaatccatttccagtttatttagttgtt
ggcagaattcagttctttgcagttaaaggatcaaagtctcctttccttgttgtctgttagctgagggtctttactagcttctgaaggctgccttcattccttggctcat
gatccccttttcttcagagcctgcaatagtgggtgaagtccctctcccattttgaatcattcctgttacactatcatccctctctctgacctacccttctgtcttccatt
tccactgttaaatgtctatttgattactctgggcccactt
819 2703246 KPNA4 YES tagttttgaactgtgatgctctttcacac
820 3226615 WDR34 NO gctcgcagcctttcttcggagagtgg
821 3373866 SLC43A3 YES attactttaaggatctgtgtggaccagatgctgggccgattggcaatgccacagggca
822 2852746 AMACR NO ctggtagcaagttctggatcttatacccaacacacagcaa
823 3023100 — NO ggctcctatccctacatttcaaatagcatttctctcacaattgattatgtattaaggcttgtcaacgaaaaggaaacttttttctctcagaatttctagaacttttttcttt
aaaaagttttttattctgtagccagaaaaatttaaagtttgtgctgggttgctttggttatagaactaatgaagcttgagtaatagtttcagacattctcagggtttttc
ttctgcagccagattttacacttctattatctcagctgtcttataaatgtattccctccatcacacaatataattagaatgtattgatgaacagatgtaacttcatcact
agagagacgttaaataaattatgtgttggtatcatgacttttatcaaatcatgaaggatgccatcacttttatgtgatagtccattggtatagtactaaagtttgtaag
taaagaatgtcagatagataacaagataacttcattttcgagatctcataacctgggcc
824 3431525 ATP2A2 NO tggtaccatccagttaagcccgtgacaaaaatggaaatttctaaatagcccaagtctccagggcaattgggaacagctttgaacccactaagatggggtctg
ctatgccaaaacatagatacagaattcacagtttgtcctgcattaggacattctcttcaactttgccactgtagaaagtggaggtaggtcagcggatggtgcca
cattaacagccgccttactgaagtgtagtcca
825 3695469 — NO tttatcctgatggaaagagtccagtagagaggaagagattgatgatgtaggagagagga
826 3761535 HOXB13 NO ctgccaccgccactaacggagatggccctggtagagacctttgggggtctggaacctctggactccccatgctctaactcccacactctgctatcagaaact
taaacttgaggattttctctgtttttcactcgcaataaattcaga
827 3823884 NWD1 YES actgcagagccggtattccatatcctgggagatgcctctgatccttggatgtgcatggccgtgctggcctcccaggccacactgctgacagtgtccagggat
ggtgtggtcagtctgtggagctcagctacgggaaaacttcaggggaagcaacatatgtccagcatcaaagaagaaacacctacctgtgccgtctcagtcca
gaagc
828 2475018 FOSL2 NO ctcagctctcacaggggtaatcatctcaagtggtatttgtagccaagtgggagctattttcttttttgtgcatatagatatttcttaaatgaagctgctttcttgtctttt
atttctaaaagcccccttataccccactttgtgcagcaaagatccccgtgcaggtcacagcctgatttgtggccaggctggacaaattcctgaggcacaactt
ggcttcagttcagatttcaagctgtgttggtgttgggaccagcagaaggcaaacgtccagccaacacacaggactgtaagaggactctgagctacgtgccc
tgtgaagacccccaggctttgtcataggaggtcgttcagcttccccaaagtcagaggtgatttgatttggggaagactgaatattcacacctaagtcgtgagc
atatcctgagttttacttccttatggcttgccctccaagttctctctctcatacacacacacacccttgctccagaatcaccagacacctccatggctccagctatg
ggaacagctgcattggggctgcctttctgtttggcttaggaacttctgtgcttcttgtggctccactcgcgaggcagctcggaggtgtggactccgattgggct
gcaggcagctctgggacggcacagggcgggcgctctgatcagctcgtgtaaaacacaccgtcttcttggcctcctggccagtctttctgcgaatagtcctct
ccctggccagttgaatgggggaagctgctggcacaggaaggagaggcgatcccggctgaggcttaggaaattgctggagccggctccaagcagataatt
cactggggaggttttcagagtcaaacatcattctgcctgtgttgggggccaggtgtgtcacacaagcatctcaaagtcaaaagccatctggggctgctgcttc
tgtttctcaggctctggggaaaggaatctccctctcctctcacttgattccaagtgtggttgaattgtctggagcactgggactttttttc
829 2987324 — NO gttggtgcccaacatatgcctgcca
830 3379421 SUV420H1 YES cgcctttccttcgaggagctcaaggcattt
831 3109159 — NO cattcagcactctcacgggatggacagagcagtgttcatgcag
832 2480318 — NO ctctgacgcacttgaggggttggctc
833 2841516 C5orf41 NO gcagggatctagacgtcaggccaactgagagctgacagggaagagagagctagctagtatagacatagacatgagaatcagctcagctgctgtaggaga
aagtcactgacagacagtagcatccaaggcatccagcgttatatgacccacgaaaacccccaaaattaaatatacacaataaaaggtcaaatgtttttcttga
acaaaagtatatttatattgaaaacaatcaggtgaagagtagaccctaatcgccagtattt
834 3738805 FLJ35767 YES ggagcttcttacctgctcacactgg
835 2771466 — NO aaaagagagcaatcctgcaagccaatcccgactctgaaaatcatcacta
836 3322962 — NO tggtggtgatgcttatagtggagagcctctaccttgctgcagctc
837 3906050 — NO tagatctccaaaatgacctctcacca
838 3119642 — NO ccagagaaagccgctgacagggaggagaggccccagcccctattacaaacccagccatcaa
839 3125570 — NO ccccaaaaccatctgcaacagccag
840 3933835 — NO ctgatggaccttctggccgcttctatgtttcttctctgattg
841 2802644 — NO gggatcacttgccacctgggatgtt
842 2854122 — NO aagttctgtgttagatagtcaagtagggtgactgtagttagcatccatgtattatatatttcaaggtagctagaagacttgaaatgttcccaacacagaaatgata
atactcatgagataatggata
843 3147610 AZIN1 YES gcaagagttgggtgtacctccagaaaacattatttacataagtccttgcaagcaagtgtctcagataaagtatgcagcaaaagttggagtgaatatcctgacat
gtgacaatgaaattgaattgaagaaaattgcacgtaatcaccc
844 3398488 SNX19 YES gggtgaacaaatgccggctgagctggg
845 3629947 — NO gaccagctctgatgggcaacccaaactcaagaagtgtaacttttctgcagaacccttcagaacttaaaagatcactgatgtaaggtcactagctggcacctctt
cttataattacaattaaatgggcaataacttacccttacataatgacaactactattaaagagaaatcatggcatttgagaacaatgacataagattaaatcaagg
caccatggctaactattcagga
846 3677823 CREBBP YES ttttgtgtgcgacaactgcttgaagaaaactgg
847 3101370 — NO taggtgccctgaaagttattgttgctttttttgttttttttttttcagtttgtgcgtgtcacttgaatcagaaaccaaacacatgtaaaaaaatatcatcctcaatgcccc
ccattaactctctctccagaaggtgacaatgttagtgaactcaagactctcactgatgatggtattttacaatgaaaacacaaggaaaccctttgaggtccaattt
tcacatcatattctccaaatagtaaaatagcagctctacatgttgatgaaaagaaatttcaatttcttcctatttgtttttactcatatcaacattaatatgtatctggatt
tattaatttccaaaaagaaaattttagttaccaaatatttcagaaatttaataaagcattacatatatgtaattagcacttatctaccaaaaaaacatatgtgtatgtatt
tatttatcttaccttcactgaagttcttttttctggctggacatgagaaacaggattaagtgatcaatgctggctttatttcttcataagcagtaatttgggtctttttcat
tcaacacaacgcagcattttcataataaattcacaaaagacaatacaaagaaacacctactgaatagaactctgtcgagcaattcatgttttaaagttggactct
ataccaaactggcattatggtattataggcatttgatttttgttttcttattttcagtttgtcagtttctttactaccattatttttttctagccggagataacgtataatca
848 2977512 — NO gccaagattagcatatgtgagtggcaca
849 2329726 — NO caagcacctcggtatagcattattactgaaaccacttaattcccagctttttgagttttttaaaaaaacccactgcactaagattcacaattcattgctacatacaaa
ttaaagctagtaagaacacactaacgtcacaagtttctcattctaaagt
850 3626942 — NO tgcatgctcacagtaacacgtatactaaaat
851 3823576 RAB8A NO gcccacggccaccagaatgcaattgagaaatcgtttattttagtaactgtctgatctttttcaactttggagatggaataagttaaaaatttgctatttttcctgtaac
atctgctgaacgggcccacccacacgttgtatattcagagagagagagggagtcaaggtgtgaccgtcgaccacagccagtgtcaggcctctgcctctgg
gcctttgctttgtggcctcactgcaacacaaagctccaccaggaggctggttcacgtcccctaccacggaagcgaggtcccagaaggccagcggtggttc
caggagcaacagctcccaaaccctgagcaaggcaaccgatcgccaggaccaggaagcatcacccaggagatttggcgcccacttc
852 3837475 GLTSCR2 YES cggagcttcctacaatccatcctttgaagaccac
853 2802804 — NO tcgagtactatgtcttttgtggcactgaaaccttataacactatgatagctctgcttccacagcagtgaaaaccgaaagagccgggctgggcacctgcctcttt
gaggtggaactcgggtcag
854 3410550 — NO atatctcgtctaacccctaccattgtgcctggccctttgaaatgtgtttcttgctgacgtgcttgtttctcct
855 2808525 — NO aaacagagtagcagttcagcccttatttgccttcaaaaaaagaaaagtacaaagtgttctctaattctggcttttagaaagttctaggaagttaaatgaacactttt
ttttcactatgaattatatgagtgaattcatcagaacggctgcttctaagaaggattttggtggttttagaaaggtaggtgtttattcctttgcctgggaagcctcac
cagagatgttgactctacaacccatctcattcgttagtttttgtggacagcagttgcctcatcgggaatttttttttttcacttccttaccatgtttcccttcggatggat
agactagcc
856 3484743 — NO atttacactttaacaacttgctgggaatttaaacaacttgctgggaacatcctttgtgaggcactgtagcctttttttatttgaaactacttaaactccaagacaggc
tcactaactctttttcaagtgcaacaacaaatgtgttagctgaaaatagctaatttaatgattatttgtgacacagacacgattatgtgagccaagaga
857 3765643 INTS2 NO ccgaaggattttgcagtcctctgtcagtaacttccattgattaggcagacatattcaggtaaaccctaatcattaaaaaaaaattatcaatgtagaaagtaattcc
cttttttctctctgagatatacctcaatcacacacttccccacccccacttgaaacagacctcttcacttgtgttttttttttttttttcctgaggtggagtcttcccctgtt
gcccaggctggagtgcagtgggatgatcttggctcactgcaacttctgccacctgggttcaagggattctcgtgcctcaacctcctgagtagctgggactgc
aggcacgcgccacctgtatttttgtatttttagtaaagacgggggtttgccatgttgcccagactggttttgaactcctggcctcaggtgatctgcccaccttggc
ctcccaaagtgctgggattacaggtgtgagccaccgcacctggccagaccgcttcacttgtaaaagaaattaggctaataagaaggtgtagtttttgagaaat
gaaatttaactttagccttttcactagtaaatagtcacatctcattttcttcctttgtaaaatggggttactactggccctacctcatattctatgagaatgagtttgtag
ctgtttcaaatcatgaagtgcatagtatcacatgtgatagaatatttataactttttattagatgcttaatgttcaattaagtaattttgatgtgaaaaataaaagtaata
aaagtatcttaaaaatagcataagaattttcatatttttaaacaaggcagttttgtagtcccttaagattaaatacaactgctccttttttttttaaactgaggccttgcg
atattttgtg
858 3810029 — NO ctggtctcagctggactatcgctgaacagaggcgttggccgcacatccccttggaaggactctttgcttccacattcggaacactgtcctgct
859 2658003 — NO cttgaaatttgagcacatcccactgtattatttcactgtatggcaaaagtgaaggaggtaggcatgttctgtcatccttaattaagctttgggctgcttattgaagta
tcattttttctatagattggaacatggtttatatagcagactatcttgtccactgacattgcccagtactgagttcc
860 2788748 — NO atgtagtacatttatgggctgtgat
861 3242486 — NO ctcagctacttaggcaggagaggca
862 3540024 MTHFD1 YES aggggagtggatcaaacctggggcaatagtcatcgactgtgg
863 3439941 — NO tgttgggaagcagcaacaatcagccatacagctttcaag
864 3457676 CNPY2 YES ttgtggaggaatacgaggatgaactcattgaattcttttcccgagaggctgacaatgttaaag
865 3843592 — NO gcctggccagttgtaactatttatcactgtctggactcataaacattttgagatgactttgggagtgcctggggagtttcattcagcctggtgcatatgggcagtg
aaaaatatgctcatctgtgatagtagatgtggtttggttcacaaatccaggggctgggctttaaacggcattaggtggacagaggagggttgctacagctgag
gtctcagctggtgcagcacaaaagtgaaatagggccatggctatctgaagccatatgtggttctgtgtggctatggagtcattccaggagacgttcacaggat
gatttgggattaccactgctattgtaaaccatggaaattctgtgttaatattggatgctatttgtatttgtcaagcatagtctggatgcttatccacattttggtataag
gccagaattgaaggcccaatatgatgtgtcactttgacatcttgtgaaagtgggacaaccttaaaaggtgtgagtacaaatctcattcccactctgctctcttga
ataatgtatcctagcctaacagcccgttttatcaaggtgataaggcagggttccaggttgttatattttgtggtgggtttcaattccatccctaccagcagagttat
ggaaacaaaccattgcatattcccaagggaatcatgggccgttata
866 2518951 — NO gcaaccctgcagtggtagtagtggtg
867 3187461 — NO cctgggaatattggcgctagagaacagtgatataatttgaggtgtctacaaatgttgtctaaaaaacctctctcctctcatcccatgtttcctctgactctactctta
aaatctaggtatcactgggaagagtaacgcactaggcccacaggaccttagtattaatataaatgagctttagttttcaaatgtcatttttttctctataactggag
aaattccattaataaaagaaccctaggggatagagggtagagggagcgagaggggagtaagggaggacacggacatacttaacactacctagggcacc
taaccatcagaaatg
868 3730738 — NO ggcagataaagtacccatactaaaaagatgtctttagcttggttgaaaaataattgtcagtcctaccactgtgagttcaaagaacttaagaaaatacagaacttc
aagcagagatatagaggattg
869 2898998 SLC17A4 YES gtgagaagagatacattgtgtgttc
870 3397924 RICS YES atctaaagagctggtctacctcgtgcagattgcttgtcag
871 2494772 — NO taaatgactgtggactagtgcgcgttttttgttttcag
872 3322617 — NO catgacccaccgtacatgcatgggcatgatctgattttttttttaattaaagttgtcacagttatcaaagtctcatta
873 3735156 — NO taaaattgaaatgcaggttgggcac
874 2346360 — NO gtattctctttcatgtggtcagtgtatga
875 3757401 — NO caccagtttagcctttgagtgtgcagagctctgccctccctcccacccctcagccccaaatccaagatttcatagccctaacacccacccaagcagcttccct
cacacatgccctttgttttcttcctctcttctatggttccttagggaaaggagccttctttagggatgaaaagctaactacagcccagtctggcctccagcagccc
agggtcagctcagcctccactggaggcgagggaggagggcaaagggcatgggagaggtagggctgccctccaggagccttccccttccctaggagcc
agtcaggattggggaggaaggcagaggggtcctagggagctgtcacatagaggaaaaggggctgggagtggggatgacaagaagtacaaagaaaga
gaaagtttggggagatggataacaagctcagctgtgtcagtgatgtggaggggaggtatggtgggggaccagccatggccctatccaaccccaggctcc
acaggccccaaattggctttgcaaatccaaacattttaaggaagtggtttagggatggaagagaaacacggtagaggtctgtgctgtggattttcatctaggg
tggtgggaacaccagagatgtctcctctgccattgttttagttggctcctggacctcatcccagcagagggagggtgactgtcagcaggtcagtcccaccgc
cactgtccccctcgcagtgggcctctgtgtctcaggcctggccaggctccctgcccctcagagctcctcgtggacccgctcctcgtcctcatctgacttcagc
ttgagctcgtcgactgtgatcttgccgtcctgg
876 2386080 — NO gggcgcttttatgaggcatgagggaggcttgataggggctttgaaggcactgatggcaattggtgaagtagacttttatctaaagggggcagaga
877 3013608 — NO tttgcctcttcgagcttggcagtgcgagccacaga
878 3460675 — NO atgaacactcgcaggtggtcaggtg
879 2564601 MRPS5 NO cacagcttgggatgttaccttgccttttgt
880 2939374 SLC22A23 YES tgataatgcctggaaggtccatatcgctaagttctccttactggttggattaatctttggctacctaataactggatgcattg
881 3320209 — NO ccaccatgattgtgcttgccgggag
882 3852627 LPHN1 YES gtgtaacaaccgcacccagtgcgtggtggtcgccggctcggatgcctttcctgacccctgtcctgggacctacaagtacctggaggtgcagtacgactgtg
tccc
883 3349758 — NO aaacaggccatgtgactgaggagcaggtagcattcatattattcatatttcgagcttggtagatgtagaattttgcagtggaggccaggagaggatgtgagag
ctgcaggacagaggcataggtttttggaggtggttgtggtgttccccgatggcaatcaacttcacggagagaagaggttattttctacttaggttgcctggagc
cta
884 3427503 — NO aggtccttcaggtgccattaatttttcttgttattcaacacatattattgagcctctgtaatgtcctaggcttgttcaagatgttcagaataaagcagtggatagaac
aggctttaaagccctgtactttattgcccaagtcaacgtccttagaatacaggtacctcacaactaccttgaggcttttattatgttattttcttctgcattcaggaatt
ccccagagccaataggatacaattttaaaatgtcaaaccatttttgatctcataccatttggcttcagtccttctttccaactgtatcattgtctatttctaaataggga
tggtctacactgtaaggctgatttgctcattgcccccacaaaatttgtcttgcattttctctgttcattcctgcacctgaaataattttgccactgccttctcaaagcc
ctcaaaccttcaatgtctgggtcaaagccgttggctcccaggaagcctgttttagaaattaaatccccaagttcttttatctgcattgattatttaacacctgacagt
tgcaacaactaagatgatttgagcgagataatgctccacattttttaccgtgtctgtgtttgtaggtgtgcccaactgacatactggctaagagttcagggtccca
885 3835463 — NO gtcctggatcatcaacttggttacaacatggtgttaacatgtgggactgattgtgtttcttgttaatatttctgtttctcccaaccacgctgaatatt
886 2809576 — NO tcaaatctatggcttaccagagagaagaccagagcgcaatatctccgtggccttagtcctgact
887 3601075 — NO atgggccaaagctggggcacaggaaa
888 3864620 C19orf61 YES gacttatgttttccgggcccagagcgctgaaatgaaggaacgagggggcaaccagaccagtggcatcgacttctttattaccca
889 3888182 CSE1L NO ggaagttctccttttgaacttgtcacgaattccatcttgtaaagg
890 3558243 RIPK3 YES cttcgggatcctaatgtgggcagtgct
891 3702633 — NO tttactcctaagcaccagtgatgacctcgtcaagcagggtgggctgcagggagatgacagcgggtatgaaagggtgtga
892 3433106 — NO tagctcaatgcaaccgacgtttctgagcccccagaatctgatccagatcccggacatataaaccacgccaagaagacaggggctgtctctagcacattctct
cgagggagtccggggccccttcccagacgcaactgcaaaaggaagggctaacgccatggcgggcccgtggtttattttatatccgacaaagtgcacggc
agcctgaactggactggaatgaaaagacgtgtctgggacgggtctacggggacgcgctgcgggacctgtccggcttggcttccaagccgctaaccaacc
gctggatgctctgcagttcgctggtggccgcctctttctccgcgcagagtttgggcgacaa
893 3544695 TTLL5 YES ggggcggggcgtctacctgatcaacaat
894 3219716 — NO gtggcatctctgcttggaagtcctattcttagtctcagcttcagtacaccctcaagctatcttatttgcttctaaaaatctcttctagtacttctgtttcagtctttgtata
gttcctatctgttctttggatattaattatgtatagtcacgtatatatactgtgcagacttatttagaggctttttgtcatattttgcttaaacctgctactgtgcaatctta
cattccagttctttcattagtatggtctttttttttcctttctcctctcttctacacttctattctacttttccttcttggtccctttgcgtagcatcttttgcctggccatctca
gttttatcttttaagtcctttttctttgttcatcccctgcttcagtgagcttttgcttctctgaactttgataacaagtattactgaaccatttatttctgggtgtagaattca
tccaaactgagcttttgagggaaccttattggttatctaattcattctcctggccagtacagctgtcattctctgaaacatccatgacagtatctacttgaatgtttaa
tggacatctcaaatgtaacgtcagagactgaattccagaccttcctccagttgtctgttcttctcatagtc
895 3442242 ZNF384 NO aaggagaaggaataagacggcaggagg
896 3293761 — NO accctccttaccttgtccttagatgcttaacatttttgtttggttttcttataaaaataacagatcttatgaaggtagaggtcagatgctgaatgagcgtctggcaaa
agtgggatctgagcagctgatgcgggctgccagggccaagccaaggttgtccccaaggcctggccttggagggtcccccccgaccggccctgtccctg
cccttgctccctgggaggggacggtggatgggtgctgctcacacccacaaggcttccctgtctagtcacagctctgtgatctccaggggggtctccatgatc
acgtcgcgaa
897 3829701 GPI YES cccaggagaccatcacgaatgcagagacggcgaaggagtggtttctcc
898 3539958 SYNE2 YES agtgagaactacagaaggcgaggagg
899 3620286 EHD4 NO ccctatattattctatccgtcctccag
900 3621069 — NO atgaatccacctaaaaggggcagaggca
901 2496816 — NO ccacccatgggaagctgatgagttttgtgtattgaattcgaagagcagagaatgggggaaaaggagattcccccattgaaaacctagataatgagagaggc
ggaaccaaaagcagactcagaacttcactgagaataatgggggtgtagtagtcaggtgagagagactggactaccaaatcatcgttgctatccagtta
902 2644239 — NO tgaagaccagtcgaaggagtgcagaccaggaaaagcgggacgttgatttggatggga
903 2832085 ZMAT2 YES tggactttcgccgaaagtgggacaaagatgaatatgagaaactcgccgagaagaggctca
904 3757844 STAT3 YES tgctgaaccctcagcaggagggcag
905 2943556 — NO cctcatctgctcctactaccttgca
906 2459948 — NO aaacttttctcgatacccttctgtgatgactt
907 3119958 GRINA YES ctttgtccgggagaatgtctggacctactatgtctcctatgctgtcttcttcatctctctcatcgtcctcagctgttgtggggacttccggcgaaagcac
908 2567115 — NO cctgattagcatatcacagtgctctaggagtcctggaacgccttcctcttccatgtgcactgctgctgacatccaggccattttggaacctgcaaatgtctcttccc
909 2893649 — NO taagtcttagtaactccgtgctggatgtgcattttgcattcagcttctttatcataagggaggaacaaagactggggctcctgctgacatctgcagacacaaag
ctgagtcggaatttgtggtcttagcttcggttcagcaccaagtgtatttataagtttgcagtcataggttttgttgtccaaatcccaacaaagccctttcccacctcc
accccaccccggaagttatatagggttccttgaagggacaaagcctctagaaaaagaaaagtcactgaaagttgtaatgtgaaaccagcaaagagaaaata
catgtttggtttagttgtggtcacagtccatggtg
910 2346547 — NO ccctgacagatctcggtctggggcacagga
911 2852745 AMACR NO ctggagcttccctggactcaacttcctaaaggcatgtgaggaaggggtagattccacaatctaatccgggtgccatcagagtagagggagtagagaatgga
tgttgggtaggccatcaataaggtccattctgcgcagtatctcaactgccgttcaacaatcgcaagaggaaggtggagcaggtttcttcatcttacagttgaga
aaacagagactcagaagggcttcttagttcatgtttcccttagcgcctcagtgattttttcatggtggcttaggccaaaagaaatatctaaccattcaatttataaa
taattaggtccccaacgaattaaatattatgtcctaccaacttattagctgcttgaaaaatataatacacataaataaaaaaatatatttttcatttctatttcattgtta
atcacaactacttactaaggagatgtatgcacctattggacactgtgcaacttctcacctggaatgagattggacactgctgccctcattttctgctccatgttgg
tgtccatatagtacttgattttttatcagatggcctggaaaacccagtctcacaaaaatatgaaattatcagaaggattatagtgcaatcttatgttgaaagaatga
actacctcactagtagttcacgtgatgtctgacagatgttgagtttcattgtgtttgtgtgttcaaatttttaaatattctgagatactcttgtgaggtcactctaatgc
cctgggtgccttggcacagttttagaaataccagttgaaaatatttgctcaggaatatgcaactaggaaggggcagaatcagaatttaagctttcatattctagc
cttcagtcttgttcttcaaccatttttaggaactttcccataaggttatgttttccagcccaggcatggaggatcacttgaggccaagagttcgagaccagcctgg
ggaacttggctggacctccgtttctacgaaata
912 3659213 — NO acctccaaggttacagcactttctaagaatgtgcctatgtagcatgtctgtccccccactgcctccaccaaaattctgagaacaaagacactgtagggattgaa
cctgaagagtattcgctggaatggtatgctaaggtttctttcctgctgtacacctcctctgccccaacaaggtgctttaagttctgttttttaatttaggaaacctgtt
ctgctattatagaaggccatgaaaagagaccagtgatttatctaatcataagcaaaaatagtagaaggctattgtcttgtcacttaagttgaatgaatcccagtg
attgtagttgcttcacgaaaaataaccaatttgttctacagaggtagtctgttcccagagattgaaaaaaaaaaagatgtaggaaagtttaaataaataaaattgt
ttaaattcacaatggagggccaattcacatggccctctgcattttgatgtaattctaacagttttactagcagaatctaacaaattttgaaagtcagagcgtatgta
tagatatatatacacatgcacacatttttttaatgatacgttatccacttaaaaaaaaaagtctcaagaatgtcataagaaactcccttaacctcaatgagcctcag
gtttctaatccctaaa
913 3296517 POLR3A NO ctcatgtaacctgggaagagccataaaggggtaccccccaccccaactgccttcctggaagcatgcctgggaagtaagctgtaggcctgatccgagccag
gaccactgggatccgtgcaaaggccaggggagggtagaattgaatcataggagtgaactccggcacctgttgtcttctgcgggtgacgcacactttaaatgg
914 3028090 — NO cttggtcgtcacattctgcttttag
915 3291113 — NO aagatctttgagttgtacttggtgtgtgctgtttttgtttgagatgcagtgaatgtgcaaatagcccagccgtaaatagttacttaaaataatctcttggtactgggt
agcagcagtagaaagttgatctgttta
916 3616816 — NO gggccgaaactgctgccgtgcattagctctgtggaggggagtcataaattctggttgtcagcgttttccgtggctttgtg
917 3842744 — NO ctccatatattagctggggctgccataacaaaacatcatagactgggtggcttaaacaacaatttacttctcacagttctgaagtctggaagtctgagaacagg
tcgccagcatggttaggttctcgtagggttctcttcctgttc
918 3956320 PITPNB YES tcccgagggctccttggtgtttcatgaga
919 2473315 — NO ctgggctgccaatctcttgccttgggggcagagcctcatctctctggctactggggttagctaccttgttggagctggcaaagccattggtgttgacatcggg
ggtgactcctgaagccgccatatacgtgctgccaatggttttgatcttggtgatcacccggaacttgggattgtccaggagctgaggccaggattcaggaaa
gaattgtcagcagtcaagggagaggaatgacccaacccagtgacagatgtacctgtttacaaggaccccactaaacccaagagacactttcctatcaaagtt
gttacttagtctaccgcttatctgccacatgatcctgggagaacttc
920 2659117 — NO tgcctacatgctccttctagctttgtttccctgatgttccttgccacctgctactcctctctgagctacttttccaggttccacagggagaggttcagctgtccgtgg
tagacatgagggtagagaatgaggtggttgggttccacttacctttctatcatcttgcagtatggatgtctcttgactggtaccgtgta
921 2826873 — NO gatatttatttgggtgcatgtttcct
922 3498544 — NO tggcgtctgatcaggaagggactctgctgcggctgtggatctgacctgggtatcagatggtgatgctttgtaaatagtgtgcctcataggggtctgttcttagtt
aaaaggagcctgcttggtgattccttttg
923 2756844 SLC26A1 YES caggccatcgcctactcattgctggccgggctgcagcccatctacagcctctatacgtccttcttcgccaacctcatctacttcctcatgggcacctcacggca
tgtctccgtgggcatcttcagc
924 3088854 — NO atgtgccctacccagacagtgcctg
925 3173548 PGM5 NO cgggagatgcttcactgatgccttcttgctacctgtttgtgcctcttatgactttggaaaaacaaaagatattttgcttttgggggatagagggtgggtgggaaaa
gaaaaaaaatccatttggttttggttttgtcctattcctccaaatgcagcagggcctttagttgtctgttaaagctgcactataatttggtatctacattttatcacaca
aaggaacctccccttttgacaacaactgggctaggcagctgttaatcacaacatttgtgcatcacttgtgccaagtgagaaaatgttctaaaatcacaagaga
gaacagtgccagaatgaaactgaccctaagtcccaggtgcccctgggcaggcagaaggagacactcccagcatggaggagggtttatcttttcatcctag
gtcaggtctacaatgggggaaggttttattatagaactcccaacagcccacctcactcctgccacccacccgatggccctgcctcccccatcccatccccaa
catccctgtaccaccttctctcacatcttctaaagctttgtacaaatcacaatggtgcacttccaacaaaatatatcaataggtgttttcctctcttattttgtaaatag
tattattttagctattaagctggataccttctttcaaattcagccattcagttgtaaagttgggaagaagtttcttgacaagactctgcaattaaatgcttaaaatttgg
aggggatccttccttgattacatcaagtatgttggtacatgggtttatacaagttcctcttgagaaggcaaaaagaccaccatgtgtgagagctctttgacttgg
ccaataggggcctatcttaatgcacttgtttggacacatttctgatcttatttgtaaaggctgcaaaaggagaggatgaaatgctgtaaaagtaggaaatgaagt
ggaagctggaagaaaatgtaattggtggtacagctatgggccagatggtggaggggagggtggggacccctgc
926 3200057 BNC2 YES tccctcccaaccagtcccatcattccaaccagtggtaccatagagcagcaccc
927 2974443 MOXD1 YES ggccatgagagtctggtgcaccacatcctgctctatcagtgcagcaacaactttaacgacagcgttctggagtccggccacgagtgctatcacc
928 2385905 — NO tctaaaaggcgtggaaacatttataagaaataccaattatgcagtgttggtgtcagtgtggacttaactgccgagactgacttattgccag
929 3639566 — NO acaggttatttctatggacaggctcttgacagaaactctgaacatggatattactgtccccttcattcaaatgaggctgaactgaggctcataagtatttaactctc
acacctagttaacacagtaagatttgaaaccagatatatatgaatccacgaagtcttatctg
930 3200565 — NO tggcatttcatgaggggaggcttatctgtgg
931 3083781 MCPH1 NO atgtagtggcctatgttgaagtgtggtcatccaatggaacagaaaattattcaaagacatttacaacacagcttgtggatatgggggcaa
932 3829376 — NO atggccgtcgtcaggagcattgtgga
933 2359017 — NO gtaaccgggggatcttgcttgtcagtgcctggac
934 3180982 HABP4 NO ggggagacttttccagctgggccaagggagtcagactctaagaacaatagatgttgcttttcccgtgtcatgtaaatttgttgcacttttttgggctgagctgtta
gaggggcttctccagaggctcgagagcaggccatttcccaagaagatgaagaatggtgactgtgtttttattgaaggaatttcaaatgaagaataatgtttaaa
atgtgtatatagagatagtatagactcctccgcggaagcatggagggaaaggaggttgtaaaatagactccatggagactcttaggaagcagtagattcccg
ggggctgtgcctttagcgttagaggaaacacatagagctggaactgttaatggaaagcagtcacagctgagttttcggagaccaa
935 3915249 — NO ccaagctgtagatcttcccaagatatttttcaggaacgaagcatgtaaacttacatgagtgaaagacagtggtaaaaaaaaaaaaaaacagtctattttgggct
ttggctcctacctaaatctagcttgtt
936 3263765 — NO tgcagagtcctacagctggttcaaggcagcatcaggctcagaacccctttctctcagctctctgttgtgattatttcaggaccttgttctgttttccacatggcctc
taatctagacacctgacctggtgggagtaacctttca
937 3303272 ERLIN1 YES ggagctcaaaaagtaccaggccattgcttctaacagtaagatctattttggcagcaacatccctaacatgttcgtggactcctca
938 2683681 — NO ggtgacccaggcacgatagctaagaaggcaaagtcgcttgttctattagctgtttaggcatctttgcagccatccttgatttggagtttttgatcttgatctaattct
atccctcaaaaccagcccttacaatctcacgtgcccacctcttccatgacagtccttgggcctagagggagggtgattgtatagttttagcagcagggcatttg
cagtgaaaaacagattgggcccagtgggatgccaaatgagagagggtcgcatct
939 2683865 ROBO1 YES tggtgtgtggcttcatacatttggggaccctatttccactccctcctcttggcatgagactgtatacaggatccacccgag
940 3781116 — NO ggcagctgccctgtaatgttctaccagtacttcagactcaacatgcacgaagattaa
941 3050281 — NO atgctgcccttcgatgaccatagtgaatgttccacagagtgtactacgagccacaaacaccagggagagaaccccagcatcagtggagtagaaacaaaaa
ggtgttctgtgtttcgcacttgggtcctg
942 3903591 — NO atcggcatagcctagatgggtcttctgtttcagggtctctcacaggaggtagtcaaggtgtcagccagggctggtgtctcatcttagcgcttggctggggaat
aatctgtttccaaactaacttggttggtgacagaattctcttcttgaagggatgttgaattgaagggcttggtttctcactggctgatggctggaggttgctctgaa
ttcctttccatgtagcttcttcaacatcacaaagctgagaaaggaatagcaagtctcctaggaagatggaaatcacaattttttataatcatggagtggcatccta
tcacattttccatagtccgttagttagaagcaaatcaccaggccagtccatactcaggagga
943 3115066 — NO gtctaggggttacaggatcatcatctaagttctgcttctgcctggacttgctgcgtaatttgaatgagtggctaaacctgactctttctcctcttg
944 2509773 MBD5 YES cactaacagaaggtttggaagcctacagccgtgtccggaaaaggaacaga
945 2322410 NECAP2 NO ttctctttggtggtttctaaagtgcct
946 2837342 CYFIP2 YES ttttgtgcggactgccattcctttcacccaagaaccacaacgagacaaacctgccaacgtccagccttattacctctatggatcc
947 2936910 — NO ttaaaggtgtagagtaagaagaatcaataccgtgtgttggatattaagcaattggtaattaatcttgcttcctttatcttgacaagatgtgctttttcacttac
948 3958553 SYN3 YES atccttcaagccagacttcatcctggtccgccagcatgcctacagcatggccctgggggaagactaccgcagcctggtcatcggcctgcagtatggaggg
ctgcctgctgtcaactctctctactccgtc
949 2901722 — NO acagtaatggaagacgggagttgcagtgctcagtcatggaattcctccta
950 3092902 NRG1 YES ccaaatgagtttactggtgatcgctgccaaaactacgtaa
951 2437102 KRTCAP2 NO tgccacgtgctcagaaattcacagcagatgcaatctcatgtaaaaccctcatgtggtaaaacaaagatctatcatggttgcccttaatcttttctcttttttttttttttt
tttttttgagacaaggctttactctgtcgcctaggctggagtgcagggatgtgatcactgaagccttgacctggtctcaagcaatcttccctcctcagtcttacca
gtagctgggactaccagtgagtgccaccacacccagctactgttttaagtttttgtagagatggggtttcaccacattgcccaggctggtctcgaactcctggg
ctcaagtgatcctcctatttcagcctcccagagtgctggaattacaggtgtgagccactgtgcctggctgccctcatttctttgcccccctctaggacttgctttct
ccgcatagcccttttgcaggcttcagagttctttccatccagtagccccgggacttctctctgttaggttttg
952 2657991 CCDC50 YES tatgccgagattttgctgtcctggag
953 2520359 — NO ctttgagcgatgaaaacagtttttatctttttagcaaagttgtagttaggatcttctgtctgtttttaggggtctccactggtattaaaggcctga
954 2592274 STAT1 NO gctgaggtttagctgtcagttctttttgccctttgggaattcggcatggtttcattttactgcactagccaagagactttacttttaagaagtattaaaattctaaaatt
ctattaatctctcattaatagtatttaatataaagattcttaaaattactgacgttatgaattggtttgatgc
955 2681309 — NO atcttctaagtgtccatgcagcttgaatcattgcacacagtcttctatgagttatgaaaataaataaaaccccctcttttccccattttatggttgtgaaactgacac
agataacacaaaagggtagattagggaaagccatatcccctctgccacccacctccaatactgatccagctttcctggatcaggctagtagggcgttgaggc
ttcttactagaa
956 2961267 COL12A1 YES ttggaatccatctcctagtccagtgactggctacaaagtcatcctcacaccaatgactgcaggaagccgacagcacgctctgagtgtggggcctcagacaa
ccacgctcagtgttcgcgacctctcagcagacacagaataccagatcagtgtttccgccatgaa
957 2854242 RICTOR NO ggctgcatcctattaccacaatggggtgtgctataactgctggtattagagagggaactttggccctttcacgtttttcttaatgtttgtaacactacttcagaggtt
tataacctcaaagcagaagaagagcctcaacaacccgggacttataagttatttttatgttactagacttgcataaagattcttgttttccaactcttcattttgttgc
aatgtgttattacaggatatatgaaccaattaaggtttttcactacagttcttgaataaaatttaaaaatcattttttattttaattaaaaatatttcccatttatagaatgc
atatatttgcaatggacttccactttcatcaactttccatctcatcgctttaaacaggaacttgaacaagcactgttagtttagacctaaaggataggaaagcatta
aataatactttggatctcctgaggaaaagataagtttgcttgcaatttacacattccatggggaaagaagagccatatttccttaaaaaaaacattaataaagctt
gttattgagaaaaattgtagtgaaaagccttaagtaccaaattttaaagcagcagtaacttaatttttatatcagtgtttttgttttgcacaaactaaatgcagtggta
ggtgggtttatgagtatattaattgcctttatccatttgtgaagttaagttgatgagggcaaggtttttgtttgtttaatttgtatatgtctaaaggtatttggaacttttta
caggaattaaacatatatgcaaatttgtatataaaaatagcatggccatcatttgaatgcttgtaaatgaaaggattatcttttttgagatctatatataaatagaaat
agaaaatccagctggactgattaggattcttttttaattcatttgtgtataacatttttattacaattacacatcagttttgacacagtcatagcaacattaatattttccc
atgatgcagatcctttttgtaatgggcttgttctttga
958 2957263 — NO tggggaggcacataacagttttttattctgggaagagccagttccccactcaacatattcaataggcacagagaccaggggaccacggaaagctccagtga
cccccgacccccgccaactcttcctaacaacatttgactccttgccctcctccgttggaactgtgcttcctggaaggaaagtgattgaagaagaagagatgta
gttctgtaaaaggcataaaaacagcttgtttttttaaaaaaataatatttttctgttatgatgcaaattttttcatgactcttctttctctcactctccacagtcatttcatc
ggcaggtcctgccagctctgcctcccaaacacattgagactgtctgctgctttctgcctgcaccaccaaccctagtctagtgacctttgaccaggggaga
959 3429874 OCC-1 NO aacagaagaatccgtaacagaagatgaca
960 3766915 — NO ctcctccattgaagcagattgattaaaacagcttaggaaagggcaaacttggatcacgagcagtggatttttttcatatctgatagtgaatttaactttttcatttct
ggcgaaattaaagagatctgtgaccaaaagtggtcaagcactggagtctga
961 2691040 — NO cgcactggcattggaacataataaactaaaattaaaatgtttctttactgtgcctcaccattgcacaatcaaaaaaaatttttttgcatacactgtggtgaaataatt
tttaaaacttggacttgctactgtgaagactgatgtttaaagtttataactgtataaacattttctatgtccccccccacaccatggatttcttataacattggatatatt
tttccttgctggactattctcttttggattga
962 2824389 DCP2 NO agtgcactgctttcttacaggaagacaactcagaacacacagccataatctgctttggtgtcagtcacatcacagtggttatacatttgtcctgaatggtgattca
ttcctttccatctaacttccttgtgacaaatagcatttactattgaaatagtcttaaaatagggaaaagagtgaaagttactcttatgcatgggagtgggcttaaag
ggttgacttccaccagctgagtacaaacaagtgtaaagaaaaactatgataaagtatggaggtcttgagaattgttcataatgaaatctttaatctgggttatca
gagtaatgaaatcaccaataaaaacattccatttatcttggatcttctgtggttagcagaggagtatggtctagctatgttagcagcttgaaggcacaacgtaaa
aggaatgagctttcacaaggtgcttacgttagctgggtagtattggtcaaaggtactctgaagagtgaatgcagaaatcagttggctgtgtttgtaatcttgtcc
cacatggaccctaacctttagtagacttcagtcttttagtccagtagaagacaatggccctgaatatgtgttttctgctttttggtggaaggtttcctgcaggtggtt
gggtggtttttgggttattggctactgttcgttcagtgccatttgaagacctgttgtttcttaatcctttttcttggtgtgactggccaggaaaaagtccattgagtcct
ttttttctccctggtgtcttaccccttctgtagaataatccatattttaaaatttgtttcacatcatttatagcaaacctgccacagacttgcaagcagtgattttatctttc
cttcctgagaaggtgatctcacttttgatgtttgggtcacctgtggacacctgtgctcttttgagtctcaaggcttatagctttcacattggcttgggaacaacaga
cttgtgtgtggttctagagtgaaatgggcagtgttctgctggtcctcagtctttgagag
963 4054485 GABRD NO ctctgcaggatcgggatcagagcgtgggaggaggtgggggtggacgtccatccggtgaacagtga
964 2871027 EPB41L4A YES cccggcctgatcagaatgtgacaagaagtcgaagcaagacttaccctaagcgaatagcacaaacacagccagctg
965 3468170 — NO gctgagcccataacctgcgtcttctgctctagcctcttgtctgtctcattcctcctctgcatggattgtctctatttggaaggtccgtggtttttatgtgtaaaatgaa
agctgccgtgttccctttccaacaccaagtctagttctctagctcccattctatcagtgtcatacctcccagcttaa
966 2739471 ENPEP YES gatactgcattcaaacgaaacatgtggccattctctgtgcggtggtggtgggtgtaggattaatagtgggacttgccgtgggct
967 3725508 — NO ccagtgctttgcactgtagctgctcaataa
968 3946498 MCHR1 YES ttcgcggtcgtgaagaagtccaagctgcactggtgcaacaacgtccccgacatcttcatcatcaacctctcggtagtagatctcctctttctcctgggcatgcc
cttcatgatccaccagctcatgggcaatggggtgtggcactttggggagaccatgtgcaccctcatcacggccatggatgccaatagtcagttcaccagcac
ctacatcctgaccgccatggccattgaccgctacctggccactgtccaccccatctcttccacgaagttccggaagccctctgtggccaccctggtgatctgc
ctcctgtgggccctctccttcatcagcatcacccctgtgtggctgtatgccagactcatccccttcccaggaggtgcagtgggctgcggcatacgcctgccc
aacccagacactgacctctactggttcaccctgtaccagtttttcctggcctttgccctgccttttgtggtcatcacagccgcatacgtgaggatcctgcagcgc
atgacgtcctcagtggcccccgcctcccagcgcagcatccggctgcggacaaagagggtgacccgcacagccatcgccatctgtctggtcttctttgtgtg
ctgggcaccctactatgtgctacagctgacccagttgtccatcagccgcccgaccctcacctttgtctacttatacaatgcggccatcagcttgggctatgcca
acagctgcctcaacccctttgtgtacatcgtgctctgtgagacgttccgcaaa
969 2818169 — NO agacacagacgggtggacccaagcattgagggc
970 3092610 UBXN8 YES ttttgctttgtggccggattttgctactgcttgctcttctta
971 2560754 — NO gcccgctatctgcatctgccttttggactccttgggggaaataaaacaatcgtgtacagttgggaggctcttcgttttcaccatcagttgactccatcagt
972 3850324 — NO gagttcagggagacgccagacaattgcagcagtttgtagagttatgtgggtcaggctaggattagttttgctgcaggaataagcaatccccccaaatcttaat
caaggtttacctaaaatcggccgagcaca
973 3209807 — NO cttctctgaaaagaccagcggccctatgactatc
974 2639722 KALRN NO ccttcttctctactgggtgcaattcgaggttgctgagcttctctccaaagtctaaaatggtggggcagtagggacctgtgagaggcccaatggcccaatgtact
tcccccagatcccactcagaacagcaggtacgcccaggctcctgctgccctagaggtctgcaacatgagtgaagaggttaattagagggacacacttatct
ctgaagtttttctccaggctgaacatttctattatcagtggcccctaatctggaaaaacccatcattctaatctagcttgtatccccacatcatgagaaagaggga
agaagaagaagggatgatgtgtggtagagaagatgagggttaactttagcctttcccaaacactggcaacaaccacttcctcaacaatttttctatttgcttcag
cctactcagattttttcaggtttttctagctcctccataacctcactccctcccgaggtctctggttcaaagaccaccctaccagcccctatttgcttcaggttatcc
tgttgagggtgggtgggaagagtgagaagatataaatgaaaaactggccacatgttgataattgttgaaactagatgatggtacgtggacattcattataccat
tctccccacttctgtatttgtttgcaatttttcataataaaaaagttttaaaagtcctccagtttccaacacactcaagagagagccccaaccccaaacacagagtt
tcatggaaaccccacaccaaggcaagaggcagagatgatgattccatttcatatatacactcattttctaactttttttaaaggcccactgctttattttcaatagat
taaacctgatttctgagaggtcctgaagttgggcttatttccctggc
975 2972483 — NO gtgatgactatgggccaggacaaca
976 2518314 ITGA4 YES gcagttggtgcttttcggtctgattctgctg
977 3680796 — NO tgtctgcttcaacctcacacttctctcag
978 2329274 — NO ctgtgggaaggactcttctaggttttggactctctaattcttctgctgaacccagtgactgtgtaaacatccagaggcccaccccacccaaagaatgtcagactg
979 3379673 CPT1A YES ttcaggcagcaagagccggcaacgccatccatgccatcctgctttacaggcgcaaactggaccggga
980 3549257 — NO tgagtcctccattccaaactctcct
981 2360474 FLAD1 YES gacatctagggcctctgaactttctccggggcgcagcgtgacggctggcatcatcattgttggaga
982 2584988 SCN3A YES aaaataagatgcgggagtgtttccaaa
983 3630231 LCTL YES tcacatgcaaatggttacggagatcgtggtacccactgtctgctccctctgtgtcctcatcactgctgttctactaatgctcctcctgagg
984 3801606 — NO ctggtgccagggctcctctcactgccctacacttgcagggaggtggacttccctccc
985 2476381 — NO agcatcacatattcaggggaccttgaaaagtttggtgtgcctgagcatagtgtagctggaaggtagtggtgggagatgagcctggagaggaaatcagggg
ctagaagataaacaggaatatatcacagagttacttaccttaaaagtaatgttgagccactgaaaggttttcagcagctctcatcaggtttgcattatagaaaga
tggtcttcaggtgtagttgaatggttggaggggaagttggaacaagaccaaactaccatggaagagactttcatctgttttgtctcagcagatagagctgtatat
gtcttctccctgtcctactgttttgggggactgagattttggtactcatcagcactcttgctctcatattatgga
986 2522188 LOC26010 NO ggtgctgacccaattcgctgccaaaagagtgtcaatcagaatatacaaatcccgtatggttgtgtcatcctctcttaatcatttttactaattctaataatcagctct
agcttgcttcataattttcatggctttgcttgatctgttgatgctttctctcatcaagactttgcagc
987 2673516 UQCRC1 YES atgccagtgtggtacgtgagatctgctccaagtacatctatgac
988 3659195 — NO gaagaagcagtgcatctgggtggca
989 2652475 — NO tctgtccctctgctagttagttctgtacagttatccccacagtcctcttcctaaagtagacattactttcttgttcaggtctagagttggttgccttcgcatgtagttaa
agttctgtagcatggtgtataatatccataacactcaaccctgcttacctctcaagaggcacctttacctgtcaccccacagtctatgtgttaaatttctgttcccta
gataccttgggcctctttctaaatacacactttcatgtccattatttccccctgtctggaatactctagagcctttcattgacaattcacttgttctttttggtgcccctc
ctcaatgtgacccttttagaaccttcatcacagaaatagttgttctgttttttcagcatctgtgattctttccctccctgtcatagaataaaatgtgtatttatagtcatc
accaagaactcatattgcctcatggggattgtatctcagcatc
990 3198107 — NO atgaagcagcacaggtacgaggtgcaag
991 2994022 — NO gtagattcgatgggcccgaggctcag
992 3548367 — NO tcctgttttctgcattagctgtttgcatgtatttagtaggttagaggtgggaactagagatcagagaattgtttatggcagcagagttagcagtaacttgagaggg
catagctaagtcaaagacctact
993 2440185 COPA YES ccaaaaaggtacaggtgcccaactgtgatgagatcttctatgctggcacaggcaatctcctgcttcgagatgcggactctatcacactctttgacgtacagca
gaagc
994 3480073 — NO atggggcttatccttactcgcagtcacctaaaag
995 3513910 KPNA3 YES ggtccaattgagtgctgtccaggca
996 3978139 — NO gaaggcctcggcaaaggactgtgct
997 2540091 — NO cagctccagggtgaaatggtgctag
998 2896688 — NO tcccgagggctgatcactggaaacagggcaacctctggtgacctggtttttcatcaccagccagggcagaagaagtcaaagtgtgctcaagggctttgcac
gctgctccctagaactgg
999 3022504 — NO actgtcttggtgttggtcaggattaatataagggagtg
1000 3104044 — NO atggcctgaaagctttaggtggtgcaacacagggtgaa
1001 3939535 SLC2A11 NO caatcaatggtgagcgtggtattccaggctaaaggtaattaactgacagaaaatcagtaacaacataattacaggctggttgtggcagctcatgactgtaatc
ccagcactttgggaggccaaggtgggaggatcaattgaggccagagtttgaaaccagcctaggtaacatagtgagaccccctatctctacaaaaaattttaa
acattagctgggcatggtggtatgtgctaacagctctagctactcaggaggctgaggcagcaggatcacttgagtccaagagttcaaggtagcagtaagct
acaatcacaccactgcatgccagactgggtgacagagggagacttcatctctttaaaacataataataataattacagactcaggaaatgcagtgaaagaaa
aatacaggttggccaggtgaggtggctgatgcctgtaatcccagcactttgggaggccaagatgggaagattgctttgagaccagaagtttgagaccagcc
tgggccacatagtaagatcctgtttctaccaaaaaaaaaaaaaaaaaaaattagctgggtgtggtggtacatgcctgtggtcccagctactcaggaggctga
aatgggaggatcacttgagcctgggaggtcgaggctgcagtgagtcctaattgagccactgcactccagcctggacaacagaaagagaccatgtttcaaa
aaaaataaatacaggttgtagtgggtatgggtatgcataccaggaggcccgacctcgtctgagaggggagtggtcagaaaagaattttctgaggaattgatg
tttttaatcaactttattgaggtataatttatacataaccaactgcatccattttaagtatatatttggcgagttttgagttctaagtatagttttggtgagtgtatacactt
gggaaacaccaccgtgatcaagatggaacctttaccctaccccaaggcacccacatgcccatttgctatcagtaacccaccccagtcccagacctggg
1002 2420794 — NO tagatctccacatgataacctgttgaactttttgagtatctgttgatcaagaaaataaagtcaaaagctacaattaattagtaatgtgctcaaaataaatttgtatttt
ataaatcataacatcttttccatgttactctgtctatatggagttcttaataccacacatttgcttagggagatggaattagcaactagtctgtgctaccctgtatttttt
ttttaaccatgtagttggattttttaaaatacaataaaagagttcacttttccaggtttgacaacatttttatgaattggaaattttctgtggctacagatactattaacat
tttggaaaggtgtaaagaacattgttttaatgtaaggctcttctctaacctccctcccctctccaaattctccataatatgaagtaggaagatatgtatttttctgttg
ccattaaaatgttctggccatcgtgggagtggggatggggagggcggggatgggaattagaacttactagaataaaattccaaatagaggtttggggaaac
ctacttgtgagtgctttttaacctcaaaataaggatttggggtgggtggagaaggtgatggggcagaagaagttgtttttggaggagagaaagcagattgaaa
ggaaaaggacagctgatagccacttaaataatgtcatcgttagagtgatacctattttttgtaaaaagaaaacaatatgctccattcttacaaagcattgattgtat
tttaatatatacaatgtaaatactatcatgcagtggtgtccaagggagagaatacagtcatgagttcttagtttctgttattggttgggccaataaagccccttcat
catccttcttttctgcttatcactagagacagaaactaaaaaccatggcttcaggctgctaaaagcctaaaacaaaacagaacaacaacaacaaataaggcag
gttggacaagcttgctgagtatttgggagcctttttc
1003 2444781 — NO taatggggccaaaggggcaacacaaagcattgaaaacatcactggctcacaaaaacagtcaccttgttaccttctcagttgcatttgtttatttcacaaggcttc
attcacacataaaaacaagatactaatccaattcaagttcataacgattataaaagtaaacatttgttgggacaatgtacaataaattgcactttttagacaagcat
tacatttacatttatagagtgtactatacataatacatggaattacggaaacgtctaattggtcattg
1004 2537266 — NO tgatacacacttcgaaccacagccagggtccaggcctgaacagatgtcagcatcttcagggagcttttgccaggacgccgcccagccacatggccaccacg
ttcattcaaacacggggcttcctgtcaaactacactaga
1005 3061935 — NO aagaggtcacccttgccgtttgatggaatgcctattatttgatagctgctgataccacgataacacagagattccctttcaattaaaagtgcctggacaccacag
ccagacaacttctgtcccaccacatgtatactgaatttcagtcttcttacatctcatttcaaatatattttgaaatatatttccagtttatataaatagtataacacctaa
caattcccatttatttgcaaatattattgtgaggatcgactgggacataaatg
1006 3893061 — NO ttcctgtccagctaaagatgctgcctggccgtggcctccacgctctgtaaacatgacccacaccccccagggcactccacggaagccttggagataaggg
acacatcacttctatgctcacctgaagtgaccccattgttaaaggacacagctcaactcaatcagggcaccagcagcgactccaagtcagggtgcaaactct
ggaggctgctgtgtgaggggggcactagagatggtggtaaacagaaaggggggcttccttcaccagccaggtgaccccaggcaagtcacaaggaacc
gctctgatcca
1007 3996137 — NO ccatggaatcctgttggagctggtctacagaa
1008 2424640 DPYD YES tgggagaattgttgctatgcagtttgttcggacagagcaagatgaaactggaaaatggaatgaagatgaagatcagatggtccatctgaaagccgatgtggt
catcagtgcctttggttcagttctgagtgatcctaaag
1009 2823618 — NO ttcctgctactggttggttaatgaggcactgagctaggaaccctgtaagtgttcaagtgttaaaattgtgttgttgtacctttaaatataaggagaagaaattggg
agagatcagattaaaatattaaatacttatatggtttagaaaagtgacagcataagggagatcaaccaggtttaagggtaaatacttaggtgaccagaagatct
acagtaaacttgaggacatatcccaccaagacccacaactcagctccagctgattgtttccacaataggactgaatgcctgc
1010 2491474 — NO atctggcgtggagatcgttcaaaggtgggaaactacgggaggaaggtactcaggtgttgagtgcagccatggggccacttgaattagcatccaggcagcc
cgcgcccctccccagagacaatcagcggtgtttca
1011 3780190 — NO cccatgatgtctgtcgtgcagatgaatgtgtccacgcgtgctgggctagtacagaagatcg
1012 3443271 — NO ccacagtatggtcattcagcgaaagaagtaccaagtatttctttctgttaatgagtcagaggtattaatatatgtatgtgagtcccccatttaccctgcgcaagat
aagttcttttaaatgcaattagaatatcctaagataaattacaaactcctcttatgtatccttttctctgaggtgaaatgagacactgcacagatgagaggtactatt
1013 3249840 — NO gcactgaacgctaatccctttttctatttccgcttctcacaggcacaggaacacaggcacaaatgcacaccacaca
1014 3365366 HPS5 NO ggggctacttttgtcagtgtctgtacccttggcatcggcatctgtgactctttatccatgacctcagtgtttcttaaccaaagttgtactcagcatttcttaaccaaa
gttgaattttgaaaagagtcagtccttgtttgctggaattagaatgttaatgtcctagtattattccgaactacagtattaactgcttgttgctagtggattagacaga
ttcttttcttactgtggcttccatgttgggagcagaagcttttcatcctggtcacatgaagacagatggtattattgactggagagttgaattatttttatatcttgtctgg
cacaatatggaaattactgaaataagacggtgtataatggaattaacacccaaaataagtagaacactgaagatttgaatttgatatttaagtaaaatgggactg
ggtgcagtggctcaggcctgtaatcccaaccctttggaaggtaaagacgggaggatcacttgaggccaggagttcaagaccagcctgggcaacatagtg
agaatgcatctctacaaaaaataaaaaaaattagctaggcatagtacctgaggccaggaggtccaggccgcaatgagatgtgttt
1015 2883453 ADAM19 NO ctggctgtatggctgcatgtgacaagccacgtcccctcccacctctccccaaacccctgcatccctgtattcacacgggtcactctgactca
1016 2924473 — NO agcagggactcagcgtgaggcttgaagcaaacagtggaatctttagaagcctgctttgtgtgc
1017 3378661 — NO ccctgggtgtaacgaggccattttgcaactacatccagccaggctgaaaacacttactttattccgagtccatcagaattcttgaaaatcagaggatctctcaa
gccaccccgctgaatatactctacattaaaatctgtcaccataggaaaatattagaaagataagtggtataattaaaaacgataaaaggaccataaaaaggat
cctaagtaatacagtataaatggtgtttgttattctgtgtatatagttatgctgttagtcaataaaatatatgcttagtaagaagcatctcttagaaaatatggagagc
acattgagaagcaacgcttgaggggttttcca
1018 3754749 DDX52 YES aggctgggtgtcctgtaccagaatacataaaag
1019 3150460 — NO gctgcccacgggactttgcaggagg
1020 2664515 — NO ttctctttagacttaccagttaggctctaatttaggaaaaataaaacaaaaacttacatgggtttggagtaaaattagctggagtaaaatccaaggctagatttcta
ttgaa
1021 3123616 — NO aggagggcccaatatccctgggtcg
1022 3432252 — NO agtggtcaaacccagatgagggtcccgcttctggtttatatacaataa
1023 2593632 — NO ggagcgggaaggagattgactgttagtttctta
1024 3054956 — NO tgtgccagccacagtacgatgtacctcctccaatctatgtgtccaaatcagcgcatcctttaaggccctactcagatggcacc
1025 3096135 — NO gggacccagaagcaaccgttatgagcaacaaaaggaagacactggtttggatggacgggaagcggttgggtgggctggactgacggaggcccctttaga
1026 3541539 — NO tgtgggctggccatctatatccatccatctatctattattccacccatccctccatccatccatccatttatttaattaagttatttttaacggttggctctggagttgac
attcatttattttaaaagaacagtgaatcatagctcttttcctcaagatgcttgcttttatttgcatggtggcatattgattaagtactcagaacactatttgacatatgg
taagccctcaataaaagtttgttattattatgactgtacttctcccctctaatgtatagaggtaaacattttggttcctattgtgacacgtgggttataatgagttagg
gcctacttaagaagaaagtggaaagaaagcgggtaaaattgttgctcagatactagcatgtgggtgga
1027 3762591 — YES ggggcggtggtcattaattctgctatcttagtatctctctctgttttgctgcttgtgcacttttctatttctaccggtgtgccagctct
1028 3305557 — NO acctgccatcctcatagtcaccgggag
1029 2394713 TNFRSF25 NO tggcaaaagagcaatctggatccgccttagccagatacataagggtatttgccttcactttcagccagcattccccccagcgatcctagccagatattac
1030 2406204 — NO ctgatatgtatctgttgggcaagtagttccatgaggagtttgtttttgttcagaatgatctttaggaaaaatggaaataccacggtgaagggaaagaagtcagaa
tatgtacacaaagccta
1031 2722321 TBC1D19 YES tgtttttcccgggatacatctgtgttgagtcactttgcattcaacagtgcctcgccaccaaaatcatacataa
1032 3532235 — NO atagtgttatatccgtgctgccatatcactaaaataggcttgccaaggcaggtgaggtgtatgaatgctcaagcctcacagaactgcaatcaagtgccaactat
aaataatactgaaaaaagttgaccatctgaccagtggataatactttcaaggcattcaattagcttatcctttgcagtattctaagctattcacattgacgatcacat
acattgtagtgcttgctgcaagggaggcatataaccagttgttttggctaaaatatgacaggaaggcattccttgggttctatataaaagtaacagtattcaaca
gtctaatggcaatcactgataggctgcttaaa
1033 3053937 — NO tgcacgctggaatcatggctcattgcagcctccaactcctaggctcaagggatccttccacctcagcctcccgagtagctgggagtacaggtgttcgtcccc
accatgtctggctaatttaaaaaaatgtctttgcaggatgggatcttgctatgtttcccaggctggtctcaaactcctgggctcaagtgattttcccatcttggcct
cccaaaatactgggattatacgtataagccaccacgtctggcctgagtcatctcttttgacccagaacaaaaccagtccaggagtggctgtactccccagga
gtgtacactggggaggcccacagctccggggtgcagtggggctcttgcaatttaatgactgattcatcttcaaaaaagcacaatctcagccaggcg
1034 3304915 — NO tgggagactgacctaactgagcatcaactatgccaagcactgcgcaaggtgtcgaggctataggaacgtgcctttctaccctagagaagtttgcagtctgct
gtgggtgatgagctatatagaagaatgtactattagatggagggaagtgagggagcaacatggttacctgaggaagagcagtccaggccaagggcacag
caagtgcaaaggccctggggtgacggtgtgtgctggctgctcatgatgcagtagggaggcctgtggctgggatgaagaatagtggagggtaaagtggaa
agaggtgagagcagagatgtagctggcagtggggagggaatagggtgaagcagcaccatgtagggccttgcaggacattctaaggattttgactttcatc
gagtgagatgaagattcactgaggggttctaagtagaggcagggacatgatctggcttcaatcatagaatgatggggattgactaggcaggatgggttatga
tgtgcaaggtcgcagggggctgctagccaggtgagataggatgtgggctctggcagcagtggagggggcaaggcactgcgggtgttggacagactctg
atgattggatgtgggcctcaagggagagtttgtgtgggagctgggaaacaactgcatcaggttgcctggggtcccactcttaggccgacaacttg
1035 3545436 — NO gcggtcactcagctatccaatgggatgacacacagcaaatcagctcttcactgcctcaacagacagtcactaaaataatttctttaaaggtatataaatgttggc
cagtgtaatcctctacaaaacacatttgcaaatataaaataatggaggtatgatgctgctcagagaatgggaatgctctggcagtccccaacatcctatcccac
ttggggctttgctccgaggggaagagcaggtgcaggatatattgccctttgatgtgatgtagatgctactagggacccactgggaagagtcccgttccttga
gttatgctactgtagggatagacccttggtgtgaggaatctaacaatgagtcaaaggaaacatcacaaagaaggtgacacctcagaggagacaaaggact
ctgaaatcctggaatcacgggatatctctgattggttagggaattcctctgcactcaatctccagcaaatgggcagattccctcacaacttagaatttttcatggg
gagtgctggactgtaccccaaacatggagtaaggtggcatcatccatctctgaagggccatactcctcgcaaagc
1036 2632506 NSUN3 YES tgaatatgatagtctgagattgaggtggctaaggcagacgttggaatctttcatcccacagcctttgataaatgtaattaaagtgtctgaattggatggcaga
1037 3333132 — NO cctgagttcctgggcactctttcctgagcttgcttggggctgatttgaattcag
1038 3459329 — NO ctctggattttgccactcacacagttg
1039 3597530 APH1B YES gccagtgaaggtttgaagagtataaacccaggtgagacagcaccctctatgcgactgctggcctatg
1040 2757682 — NO aacagtgcaagaaaggacgcatcactctcttctggtgccgatgtgctctcttgttaa
1041 2811303 — NO tcacgtggctttgtgtaccaggcgtccagggagcaattaggagggcaatctgttaagtcttttgcctcagggcagaaccattaggtgtgctgtgtatgtgcctc
aaggggtgtaaataactaagctattcatgtactcatcagtttcctttcaaggcatctgtgaaacctttaatctgtggaagaatcagagaaagttgacctattgtatt
attatcctccctcacctgaatattttga
1042 3611032 TTC23 NO gagtccttttgtcctgcggtccatataagagggtctggatctggagacactgtagaacaccaagcagctatcatgaggctatggaagtgtcgctgagagcag
gaaactaaggtctcccttgaatgagagaaagatgacctcattcttaggccctgctgtgatggaattagcatgctcctgggatgtctcctagtgactgacctttgg
tttggatgttctgagggatctaggcaaaagtgaacagttttagcactatttcacaaaactctctgtgactatctgtatgcaaaaaatagatttaaaagtagtattttt
aaaaataaaggcaagaaccttggtactgaccagaggatgggctccagtttctatttttaaatgtggcccttgttatagcctggaaaagatttaaaaaaatagtttt
gttttttttgtaaacacatactctacttttattaatatataggctgtctatactcttgactacacagcaatgtcttagttattaggaaccaaatattcagcttatggacta
cccagggctggctttggcttgatttctcccttctgcttactttaagtcttgccatttgattgcttgtagtaggctagggcaaatcaaggagaggagaaagattaaa
gttgtgcccaaaatggccaaaataattttgagaaagaatgaggtggagaggtggaggaacttgctttactgaatgccaaagacccttttatttttttaaataaagt
aattaagacagcatgtttgtcacccggggtagacaaaaagaccagtggaacagggcagagagcccaagccttgacagatgacagaaatggccttgcggg
attggtgaggaagaggtgggctagtcaataaatgggtactgggaccgctggttttccaaatggaagaaaatggatcactaccccaaatcaaacacaaatatt
aagctcaagaaagatttgaaggactaagtgtgaaatgcaaaacttggagcttttagatgaaaatactggaaaatatata
1043 3977071 — NO gtggctggaccatgcggaactggat
1044 3363301 DKK3 YES tgatggaggacacgcagcacaaattgcgcagcgcggtggaaga
1045 3644748 — NO tgggccacgtggtgctctctgaagttagaa
1046 3799937 — NO catgcagtccccaaggctatcggtcctcctcag
1047 3336773 FBXL11 YES gaggagcttgccaacagcgatcccaagttagccctcactggagttcctatagtacagtggccaa
1048 2822962 — NO tgtgagaacagactcggcagtgacatccactccaaatgga
1049 3627325 — NO ccagacctgagccacgtagctatcaaacac
1050 3780263 — NO catctgaaattaatgggactaatgtaaggattgatattttcatatttgctcaattgcatcctgggttaagcacattcaacag
1051 2656010 VPS8 YES atggcgctatctctgccctcagtatc
1052 3028587 — NO tcacccaggattctcctgtacctgctcccaatctgtgttcctaaaagtgattctcactctgcttctcatctcctacttacatga
1053 2419066 ZZZ3 YES gttgcctttgagtgatggtccagaag
1054 3081481 — NO atggccacctgtgttgacgtggaga
1055 3935290 — NO atgatgaaagcgtggaggtaccagct
1056 3051677 ECOP NO ttgatgtgtgaacgctgacctgtcctgtgtgctaagagctatgcagcttagctgaggcgcctagattactagatgtgctgtatcacggggaatgaggtggggg
tgcttattttttaatgaactaatcagagcctcttgagaaattgttactcattgaactggagcatcaagacatctcatggaagtggatacggagtgatttggtgtcca
tgcttttcactctgaggacatttaatcggagaacctcctggggaattttgtgggagacacttgggaacaaaacagacaccctgggaatgcagttgcaagcac
agatgctgccaccagtgtctctgaccaccctggtgtgactgctgactgccagcgtggtacctcccatgctgcaggcctccatctaaatgagacaacaaagca
caatgttcactgtttacaaccaagacaactgcgtgggtccaaacactcctcttcctccaggtcatttgttttgcatttttaatgtactttattttttgtaatgaaaaagca
cactaagctgcccctggaatcgggtgcagctgaataggcacccaaaagtccgtgactaaatttcgtttgtctttttgatagcaaattatgttaagagacagtgat
ggctagggctcaacaattttgtattcccatgtttgtgtgagacagagtttgttttcccttgaacttggttagaattgtgctactgtgaacgctgatcctg
1057 2699603 — NO aaagaaggatctgtcagccaagtcttttct
1058 2836754 — NO agtgtggccgtttgcattactgctggaattttgaagactactacatattccgtcagtgtcaggattttgttcttcagtgtggtacttttttttttttttttttaagatggagt
ctcactctgtcgcctgggttggagtgcagtggtgtgatcttggctcactgcaacctccagctcccgggttcaagcgattctcctgcctcagcctcctgagtagc
tgggattacaggcatgcgccaccacacctggcttatttttgtatttttagtagagacggggtttcactatgttggtcaggctgttcttgaactcctgacctcgtgat
ccgcccacctcagcctcccaaagtgttgggattacaggcgtgagccaccgcacccggtagtgtggtacactcttaaaatcatagttcctgctgtctg
1059 3504560 — NO gcatggccatggatcgggcaagttggttttact
1060 3924596 PCNT YES agacctgaaggcacaatcacaagaagagatcaggcgcttgtggtcccagcttgattctgccaggaccagtagacaggaatt
1061 2408919 — NO taggtgacggattgttaggtgcagtaaacc
1062 3219942 PTPN3 NO ggaccaggcttctaccattaattcacatgctttaaaaaaattaaaaattaaaaaaatgaaaaataaaaaaacttaaaagattttacctatattcctggaacatagtt
atcttaccccagctttgtagttcctgtttaaggaaattccctctgaaggaaattttagctctcaagagtcaaagaagatgtatagaggtggtatctgttagtttttgtt
tgtttgttaaggatctaggcagagaggtcattacatttttctgaagttgaggtcacaggtggggtacccacaagagaggtcattacatttctgaagttaggcatc
ccaggcatctcttctaaagaactatcctgtattctaattgttaaataaatatcttcttcattgtgagcctccacaactgctgtttctgataaatttagatcattctttgca
gaattttatatactggcaatctcaaaactaggctccttcaagattcctaggaagtctcccaagctcgggttgggttccactattctag
1063 3240958 DNM1P17 NO gtcaacaagaccttgctggacctcgtg
1064 2830809 — NO gtgcagattgttaatccctagtgtgcagggatagggagggagaggaaatgtccacacagacgaggagaaggcctgtaaatgcaaatttcacactgttgatg
gtttgtcctgttggttgaccagcattcccaagataaccaggtgag
1065 3020549 — NO cctcatgcatgcttcgagatcattgtttgcttcatttccctaaaatctacagttcctttgaaagtagactctggcgttatcacctttccccggtctttttgcagtttcctg
ttgacctctgagccattctccctcactcttgtttcactctgtttgcaacactacctcttcctgtatcctggcctctcatttctcacagatcatcatgctgttcttgaaac
attttatttacttgattttagaaaactatactcttagtttccctaaaatctcataatctctttgcgggattttcctcatctttgtgacttccaaaatttgaagtgtcccctgg
ccagtcctgggtggctacattcaatctc
1066 3282482 — NO aaaagaagtcgtttattggtgcatgggacactctgggaggtagtatccatttggatgtcctgctgcggttggagacatggaacaaaa
1067 3192070 — NO cctgtcggtggactgaatgggccaagtgttcagaagtccttgggaagaggatagtgtcctgaatcataatgtggtattttc
1068 2473609 — NO aaagtgtcctattctcggggtggcagggaggggggcaggccacaaaggacatgagtgttaggaaaagaagaaagcacagggaattaaggcaggaagg
gataggctaactactgttctgtgcaaatgcaattgggtttatgatcaggactgactgcccttacgtataaagttgctaacccccaagacctgaagggaaaagtc
ttttgaagctgccagttttttgatcattcaacaagaagacctgaacactgagaatcctttttctggattggttccatcaatactttgtccctgaaatcaggaaatacc
ttgccattatgggacagccctttaaagttcttttgatgttggacagtgcccctggccacccagaaccccatgagtttaacaccgaaaacattgaagtggtctact
tgcccccgaacacagtctctaattcagcatctagatcaggggatcatgaggacctttaaggttaataacacacggtactctaacctcaatagaacatcatgaa
aatctggaggaattacaccgctgaagatg
1069 2814779 — NO actctgctgactgtaatggctctcacgcagttcctaatgggcactgtggaaccactcagcatagacaggcataggcagg
1070 3558342 — NO gcccagtgaaggggtgacagaactagcc
1071 3611698 LRRK1 YES atctcctgccagatcacggagctcgacctttctgccaactgcctggcgaccctcccctcggttatcccctggggcctcatcaatctccggaagctgaacctct
ccgacaaccacctgggggagctgcctggcgtgcagtcatcggacgaaatcatctgttcc
1072 3701429 — NO tgccgcttttccctccacttgtgtaacagcatactcaggtttataccaactgggagacacgcaggcatctcccctcacaagcagctgtctactcaattctgtagtt
atgtctgctaagtaatcagaatgcacaataggtttttagcatctgtatctcatcctcagagtagagagtacctgttttacgagagaaaactgagaaaacggtctct
cagggcctctggggcagccttcaattggacagcagtagaatttcggtccagttttcaaatcttttcttattgttggattgactatgccatcctgcaaaaggaaaat
tactttaaattattatttcaaaaaaacaacacaacaggctggagtggaaacggaatgactgaaaacgagcacattttgtgaaatacttttaattaagagtttttcca
tctagtgtcagcagtaagagaaaaagagtatgagtagattaaacgaaatgtggtgagaatactaagcaagactctaaaattctgcattcatttgaccattactg
aattcctcttagtcaatttacattccagggagatgccccccttgtatgttcctaggctgtgaaatgctcca
1073 3933333 C2CD2 YES ttccgccggcggcatcaacagaaagacccaggcatgagtcagtcacacaatgaccttgtgttcctggagcagccagagggttcccggaggaaaggcatca
1074 3799749 — NO ttggattccactaatcacccgatcacccc
1075 2487131 ANTXR1 YES gaaagctgcactccaggtcagcatgaacgatggcctctcttttatctccagttctgtcatcatcacca
1076 3187719 — NO gggcaaacttcagcctcattagatagaggctggacttccggaagagctgggaagggggaccatagtttctggggaggggtggagaactcacatttaccta
gctgctggccaggctattttcatacccacagaccgatttaattctcaactactgtactcatttagtagatgagaagaatgagacattgaaaacatgcacagtgga
ggtgggaatgaaagccagctctccaactctccagtcctctttcctgtcactgcatcaggctgcagggtgaaggggaggtctgggatacaaagagaacttag
aggtggagcagttggattctgtgcagtgctaggagggaggagaggggttggagtaggtgggaagtaggcctccttcagtttggatagcacttcccttaacc
caatgactctagtgggagggtggagggatggggatgggaagggagcctgggagtgaggaggaaaggcaaactctgtcttcccccaggggagtcaatg
aatagtacc
1077 3474744 — NO ttagtgtacccttcggtgacaggtaagggctttctgaaacgcattgtctttttattatagccattctagtagtaaggtgtgaagtggtatctcatagtggtttgggtt
gtatttccctgatattgggatgttg
1078 2489696 — NO atgcagttacaaaatcggattcagcatcagaacag
1079 3195395 ARRDC1 NO gtgagtcgacagccagggcttggca
1080 3497381 — NO ggtggacagtgatggtttcaaaggggaaa
1081 3130174 GSR YES tcattgttggtgcaggttacattgctgtggagatggcagggatcctgtcagccctgggttctaagacatcactgatgatacggcatgataa
1082 3180421 — NO gagaggtggatctgtctggacttcaggctgtgagaacctcacagcacagataggatgtgagctttaccccttgtgttcaggccgctcgcacggagtcagctt
gcggaagcacgttcccaggcctgctctgcgtgtaatggtggaatt
1083 2384882 GALNT2 YES gaagtcggtgaagcacatggatttgtgccttactgtggtggaccgggcaccgggctctcttataaagctgcagggctgccgagaaaatg
1084 2601621 — NO tctcctgcttcctagacgaaatctaagcaatattttatccacttctttttagtaaaagaaatacatattgcctgttggggtcatgagctatgtagggaatgaaaaaat
tttttaaaggagaattataaagagaaggaggatacaagagaaaggaaaacgaaagctggtgggaagttgagccatgtttatctctagtggaatccttaccttg
tgttt
1085 2624206 ITIH3 NO tggatggcccggattttatggcatctggaac
1086 2626149 RPP14 YES tcaagattgtggagttggactgaatgctgcacagttcaaacagctgcttatttcggctgtgaaggacct
1087 3466862 — NO tgtcacttagtctactgccagtctactgtctgtgccaccatgggaaattgcatgagttcagacctgtgaaaaatcagaataaagataaaaacacattttttgaag
gttacggaaattcttaagatcttggttttcttgaacttactactagtactactgatttagaaatggcctacctcctatagtaggaaagggcaaagaaaacaatagtt
aatagggaaggcttaaaggagcttgagggctgtcctggcaataatagaagagatccttgttttttaaaggagagttaatgtacaaagattctgaaaagtctaga
aacatgggtaaaatttttatgattgccgggcgcgg
1088 3400762 — NO tcaatgaccagcgtagacagagctagtagcagcaatgagatgagtgactagagaggtagagagaaaaccaggaaagtgtggagtcatggaagctaagg
aagatggtgttgggaatagaggtggtgaacagagtcccctgttcttgctgataggagaggtcaaatgagataaggacagaggcgtggcctttggattccga
gatgtgttgatcaccggtgcacttggcaagcatgcca
1089 3511392 KIAA0564 YES aatcccgcttccctgtactttatgaatatgactgggaaaagtggcttctttgtggacttttttgatatcttcccaagaacagccaatggcgtttggcacccttttgtg
acagtggcaccgctgggaagtcctctcaaaggtcaagtggttctccatgagcagca
1090 3762555 — NO tgcacatgtggtaagagcatccagcaggaaagaagagggcaagttgagtgtgcgtgggcatgaaggattcactgtacgcatcccagccctgctcatctca
gccgcatggactgggcacacatttaagcatggagggtggtggttttcaggctgttttctagagctgtagaactcaaatgaaatgctctgagtctgtgaggggg
ggaggagtcaataaagggtggctaagtgcatggagtttgaggtacccgctctgctgtaacc
1091 3853067 ILVBL YES gcttgctgctctcacgggagaacgaggatcaggtggtcaaggt
1092 4015570 — NO ttcatggttgcctagtgctgcgaggagtggggaatggggaatgagtgcttaatgggtatgggtttcttggggtgatgaaatgttccggcactaagttgtggtaa
tgactgcatgactttgtactaaaactactaaattgtacactttaaatgggtgaattgtatggcatatgagttatt
1093 2458440 — NO tgcacttttgcctccgaactctcgtgtttaatta
1094 3333734 SLC3A2 YES atgggttccaggttcgggacatagagaatctgaag
1095 3379257 — NO ggccgtgcagcttcttgacaaattgcaaaggtgcccacgagtttccaagt
1096 3662461 NLRC5 YES ctcaacttgatcacgaggttcctgacaccgtccgagctcctttttgatct
1097 3670791 — NO gtgcaggtctaatgggctccttccttc
1098 2689662 — NO ctcatggcaacttcttccgcttcctagtttca
1099 2698749 XRN1 YES gctgggatcactatggaagcaactatgcattgggggca
1100 3940626 — NO tgcaggctttacctatgaccgaacatgcatggaaatgccctctgatggactcaggcatgatacatacatcaaacagccttgcacggtggta
1101 2577438 — NO gagagcatggctacaacagcaatatttctggaaaccagttatcgggggaattcacagg
1102 2885881 — NO atggactcatcccagaacaatcctcaggcactccgaaatgcagatgccc
1103 3473848 TAOK3 YES atggctccagaggtgatcttagctatggatgaaggacagtatgatgggaaagttgatatttggtcacttggcatcac
1104 3721713 — NO agaacctggtcgtgtcttgagaacccagtccaaacagaatcaggcctctggactgggagcaacactcccttcacccgcaaagattcaggaaaagcacccc
aaggacaaggaaaccaatgaggtctgggctagctctgcagctttaggatactagctctagggaaggattttttcctttttaaacagcgtatcactctgttgccta
ggatggagcacagaggcaccctcatagctcactgcagcctcaaactcctgggctctggcgatcctcccgcctcagcctcccaagtagctgagaccacagg
cacgtgccaccatgctcctagggaaggagcttgagaagaaactgccaggagtgaaccagggctggctgctctgtgatgttctctccccacctcccctccag
ctctcaacttggtggcagggccggcaccctgctctccctcctaactcccagcctgctgctgcccccttctgggaccctaattttctggactttgagaaatgggc
tgcccctgggggtgcctccaagagcccatttgagggatcgggtggggctgacctctctgtcttctttggatcatcgccttctcacactgtcctccctcttgattct
gaaaaatggtcctgctgcccatggagaaccacagtaagatagatttctcatgcagctagtgaggggacttc
1105 2924660 — NO accatgtttttgcctccagtctgtc
1106 3242466 — NO atggctatgggaatatcgggagttgaggaagaaaaaggctccagtggcactgaag
1107 3268238 BTBD16 YES agcagctcaccaccggctgcgagaagtggctggaaatgaacttggttcctctaggggggacgcagatccacctccacaaaatcccacaggacctgctcc
acaaagtgctg
1108 3293847 SPOCK2 NO tgtggcatgcgctgacaaatgtgtccttgatccacactgctcctggcagagtgagtcacccaaaggccccttcggcctccttgtagctgttttctttccttttgttg
ttggttttaaaatacattcacacacaaatacaaattgacaggtcaaaatcca
1109 2416565 JAK1 NO aatcttgctttttgtggcctggggattggctgtgtgatcagcattgaaatgggttgttgcagtttgaagtctggaaggggtatgtccctgggttctaattctttccct
ctaggtttctgtactcagctcagagtctagaatggtagcttttaggattggaaaagaccaaagttacctaattcaactctttcatttttttttcagtggaaaaactaat
acccagaaaagggaagagagttaacccaaaaattacatctagtgaattgtctgattagctttacaattgaggcattgtagagctctttgaggcattagtcttggtt
gtctgagtgcctggctattaaaggctgtctttgcctgttccctctttctgttagctgcctggaagtgcagggttgcttcacttttagcaccttgactctgtacctgac
atggtgcttcaacaggatattgc
1110 3198506 — NO gtctacgcagctgccatagaggagggggattgtttgggagaccttcccgtggcagaatcaaagctcgtagttcagctgcgggaatctggtgtacttaa
1111 3384336 RAB30 YES gggaagacgtgcctcgtccgaagattcactcag
1112 3649726 — NO ttgtgcaacagaaaactcaacccaa
1113 2732288 — NO aggtttagttgtgtggccgtaatcacatccaacaccaagtcggccaaccatatgtgagcttaatcccacagaattcttatgttagacctccctcttcagataatag
aggagattttttttaagtatacgtgcacagaggaagtgacttctttctgcgcactctgttgtcactggaa
1114 3291868 — NO tacgaggaagtgaccagtgttcatctgaaacggatgccttgtttctcagaaatgtcattctctttatttcatcttcgtagttctgtgccttctctcagcaatttctgattt
ctttatttactgccacacagatgacaaatgacatgcatgtccatgataccctttactcaattcacatgcgatttccaaggctggctataattcccaaa
1115 3572359 — NO gtggggggctgtaatctacaaaagccatcttcagtaccaggtttaattccatcattgtttttcgggttttaggtctctggactattgtcctttaacaacaaca
1116 3613987 — NO gcctgcctgttcatgccaaatatacatcctcacaatgcacagtacacaacatgggcacataggcacagaggctatgccgg
1117 3768275 — NO ggctttgaagggcaactgaccaacttttttatacataaaggatataaactacaactattttcccactctgtgtagaatgtggaacggaaacagtgtgtggcacac
tttaaatgatgctaaacttctacagtgtgtaaactggcttgttcaagaggccaaagtgcttctgttgagaaacactgatgaccaatctcctctttgtggtcctgtga
tactgtgaaatatatatttgatcttcctccctgtttcccagcatacaattcctaaaaccctcagaatctgcaaaataagatttttttttaatgctaatgattgactgatg
gctggaggctcctagagagcctcaggattggggctgattctcagggctttc
1118 2367980 RABGAP1L YES gaccatcttctccaggtggactacctgaagaagatagtgttttatttaataaactgacctacttaggatgtatgaaggtttcttccccacgtaatgaagtagaggc
tttacgggcaatggcaaccatg
1119 3063344 ZNF394 YES gtgtgaagaatgcgagaagagcttc
1120 3147137 — NO tttaggaaaaggctgctatactgtggacgaagtctcagatcagaa
1121 3737089 CCDC40 NO acgggacgctttctctgggatgcattgagtcagggaatagaagatggggtgaatgatgtttctgacccacagaccgttgggatgcttttgctgtcactttccca
tcatgctgcatgaggcatgacagcagctgt
1122 2686311 FILIP1L YES tgccaagcatgcgatattcagagtctccccagaccggcagtcatcatggcagtttcagcgttcaaacagcaatagctcaagtgtgataactactgaggataat
aaaatccacattcacttaggaagtccttacatgcaagctgtagccagccctgtgagacctgccagcccttcagcaccactgcaggataaccgaactcaagg
cttaattaacggggcact
1123 3307401 — NO gccactctgctcaaagttggcacgagttggaatgtaatcaccatctctgcactcaaggcatgcagaaatgaagtctacctcagccctcaaagacctcacctg
agaaaaagacaaggctccaaacagaaggcaaaacagaatgagcatagaaagagaccactttttcacatacctttacaaagcactgctcacccctccttaac
ctcgcacagacagagcatggggcctcagtgtcactgccactgccaccctcccactgactagctgtactctctga
1124 3648042 CIITA NO ctctgaggacactaaccacgctggaccttgaactgggtacttgtggacacagctcttctccaggctgtatcccatgagcctcagcatcctggcacccggccc
ctgctggttcagggttggcccctgcccggctgcggaatgaaccacatcttgctctgctgacagacacaggcccggctccaggctcctttagcgcccagttg
ggtggatgcctggtggcagctgcggtccacccaggagccccgaggccttctctgaaggacattgcggacagccacggccaggccagagggagtgaca
gaggcagccccattctgcctgcccaggcccctgccaccctggggagaaagtacttctttttttttatttttagacagagtctcactgttgcccaggctggcgtgc
agtggtgcgatctgggttcactgcaacctccgcctcttgggttcaagcgattcttctgcttcagcctcccgagtagctgggactacaggcacccaccatcatgt
ctggctaatttttcatttttagtagagacagggttttgccatgttggccaggctggtctcaaactcttgacctcaggtgatccacccacctcagcctcccaaagtg
ctgggattacaagcgtgagccactgcaccgggccacagagaaagtacttctccaccctgctctccgaccagacaccttgacagggcacaccgggcactc
agaagacactgatgggcaacccccagcctgctaattccccagattgcaacaggctgggcttcagtggcagctgcttttgtctatgggactcaatgcactgac
attgttggccaaagccaaagctaggcctggccagatgcaccagcccttagcagggaaacagctaatgggacactaatggggcggtgagaggggaacag
actggaagcacagcttcatttcctgtgtcttttttcactacattataaatgtctctttaatgtcacaggcaggtccagggtttgagttcataccctgttaccattttggg
1125 2568862 — NO tcttcttctagcagtgctcagtgggt
1126 3405549 DDX47 NO tggcgtgagcgagataaacctcctaacagtaggtttgtacaataaggccatagggcaccgatgcctgtttccataattgttgtaattttatgggctttgaagtgtt
gctctagatacttactttctcctttcagggtagcgagaggctcccattagaatatttcatatgtacctgtctggtttgcaagctgttgagttgatttattcagccctag
tggtaataatgactc
1127 3479324 ANKLE2 YES aactgaaggagcggatcagagagtattta
1128 3736140 — NO tggatgtctactttgcacgctgcgattgggagagctgtcccgctgcatgcgttccctctgtaatttcctcagagctcacatacgtacctctctcacgagtgaact
cagattttccattgttttgctttattctatcatttgctttgtggttttgctgtaaatattgaaatcttaatcatcatcgagaggcacagccaagctttccagctctccacc
cccgtggcccatccaagtctgttcatctggtaacttctgttgtctgggacggcagcaagaagatgccggggcttgcctggagtcctggcagaggagtgcca
ctcacttttgcctagggtccagttggggcttaaaaaatatttggagagaagagtaatgaggattttttgtgtttcctagacattttatgcatctatttttgtaaaatcac
cttcgctaactttcaccaagcactttgagcacagtggaacttcagaagcacaaccagcctaaccccagaatctcaggtggcacagctagaaattgagtccctt
cctaggacactggccgtggccttcagggtgaccagtcagtgccaccgggttggcattggtgttacagacaggcctctgaagacaaaccgagcaccccag
cggcccctcaaactaagcaaggatcttttttctgtctgcgctccctggggcaaggtcaaaggtggacccgcccactgtgggtcaattcatcgaaaagatgg
gacccgcacccccgccacaggctggcccccccccacccatggggaaggtggtgtgctgctggctctgaccatactcttttggaaattgagaaggaaagca
ttgagtgggacctaatccggagaagaaattaaagaccagaaaaagaaggaagctgggaatgaaactcaaaatgcacttgaacctggaagcggcaaccct
cagctctgcgcggccgagcctcagcaagagttcgttt
1129 3954953 — NO catggtctaaccacagaggggaatactactcagcaatacaaaggagtctctcctaatacgtgcaacaacattcatgaatcccaaaaactttatctggagccaa
gccagacacaaatgtgtacatacagtacggaatgacttcagattctgaaaaaaggcaaatctgaccaattgaggcagaaagcaggtcagtggttccccagg
tctgggactggggtgggttactgatagcaaatgggcatgtgggtgccttggggtagggtaaaggttccatcttgatcacggtggtgtttcccaagtgtata
1130 2396759 FBXO2 NO tcgagggtagataggccttaacttagtccatagcgtcctcaccttccccaagccacacatcctcctcccatcccttgctccgatcccagcccctgagcaggga
gagagaagttttgttggcataggtttgcttaggtagccggcttctagaatgtagatccgtgagggcgtgagcttggactggacccactgctgattccctgcac
ctagcacagtgcttgccacaaagtgggctctca
1131 2519281 ITGAV YES ggtgagcgggaccatctcatcactaagcgggatcttgccctcagtgaaggagatattcacacttt
1132 3640619 — NO tctgttgtctcgcccttgctctgctcctacttcacccatcttctgagatccaagtcaaaatcatctgcacg
1133 3976861 HDAC6 YES acctaatcgtgggactgcaagggatg
1134 4048293 — NO ggggtagaacaatcaagcttattcctaaggattttcttttgacaaataaatgggtggtagtgttgtttattgagataggaaaaactatgggaggaaatgatttgaa
gtgggtggtttgaaataaaagttttgtttaaatatgagatgattgattgacatttatgtggagaaatccgaaggtcaatggcatttaagagactcatggtgaggcc
agggcttcaggtatttatgttggcagcagcaatacgtgtagtgtgttaaattccagggcgtg
1135 2393657 KIAA0495 NO ccctgtttgtctgagccctttggagatttaggttgagtcatgagaaccggtcattggaacatacactttattatgttacaaaaacaaaaatccccactgaaacaca
gctaaaaaaataacacattttcccaagattacattaccaaaaacagttgttatgtcattggagggcgtccattaatactgctcggagaagcacgatcttaca
1136 3389355 CASP1 NO aggtttttggaattatgtctgctga
1137 3584178 — NO attgtagtttgaagagctgcccttgggaactcatgggacaggcatcaggcctggaatgggatggacaagtggggcctccaggagaaggagcattgcagg
agatgctggagagtggggagcagtacgtgcagcagatagggga
1138 2365984 MPZL1 YES tcaccagttaagcaggctcctcggaagtccccctccgacactgagggtcttgtaaagagt
1139 2468456 — NO aaagcaatcttaacagtgagggctatgaaaccgttgaaaattctcccaagggaagtgatggaaacctccttgcttgagtcatttcaaagtcgacaaaacaacg
aaaaatacatggagggagggatcctgtagtgttggggagcagactcgatgatttcatagttcttttctgtctctgatttccatgttctgtgaaatagtattgcagct
aagaaacatgaaatccttcactccgacagtatg
1140 2954656 YIPF3 YES acctgcttcggctactggctgggagtctcatccttcatttacttccttgcctacctgtgcaacgcccagatcaccatgctg
1141 3499189 ITGBL1 YES agatggcatattgtgctcggggaagg
1142 3102170 PREX2 YES gaaggatattattacagagacaatgtttctgtggaagaatttcaagctcagataaatgcagcctcactggaaaaggtcaaacagtacaaccagaagctc
1143 3151372 — NO caggcactgtatcaggtgctgcgtacttctgctagctcatctcacctggtcatgccgctctga
1144 3153640 — NO ttcttccttgatgcaggatctgaggttgaag
1145 3708351 — NO tcacattctggggttagaaggggcccaatggatgggaattcttcatataaaagaggaaatgcc
1146 3793991 — NO tgcaacaatgggagctttttaactagtctctgtaaggcgttgtcatcacatctg
1147 2840186 DOCK2 YES catgagttcatgagtgacaccaacctctcggagcatgcggccatccccctcaaggcgtctgtcctctctcaaatga
1148 2945913 CMAH NO ttgcctcccggagtgtgtaaccacatgagaaatagagggaaggttctgtccttaagaagttaaaagtgtgactgggaaggtaaaacatacttattaagggtta
actagcatcatgccattctgtgtgatggtgagtttgtgtgtgtgtgcacatgtgcgtgagtacacacatatacatttaaaaaggtcttgaatataccaaaatattat
gtctaggtgatgggtagcttgtatattttttctgtatccttgtctgtgtttgtcaaattttatagaaacaataacagtaacagctctctgaccttctaccctgtatgttct
gcgtcctgtctaattcctcaagttccttcactgcctgtcactctgatgcttgctatatatcagcccatcctgctttttgtttcttagacccaaagtgtcaagtgcacac
ctgccctgggtctttgtgtttgctgtttccatttcctggagtgcagctggccctgatttgcatgtgaccagca
1149 3706405 PAFAH1B1 YES tcgtcactggcagcgtagatcaaaca
1150 3898481 — NO atggcggcagagtatctggttctctt
1151 3962245 NAGA YES tgctcttgctgggacatgtggcccaggtgctgatgctggacaatgggctcctgcagacaccacccatgggctggctggcctgggaacgcttccgctgcaa
cattaactgtgat
1152 2877309 BRD8 YES cacagagccatggtccatccgagagaagctatgttt
1153 2973720 — NO gtttggtgtctggtacttagagctccctgaaactgtggtgttt
1154 3091762 FZD3 YES aatcatttgcctctcggccacattgtttacttttttaacttttttgattgatgtcacaagattccgttatcctgaaaggcctatta
1155 3418179 — NO ctgagctcatccagtaaaactctcaaaagatgaatagatgcccttttccttgaggagccttctgcctgatttctttgtcactgagtttgggtccctggttggagtgg
caggaggaaggggtccaccacgtcttctgac
1156 2685385 — NO tttggtgtctttctgaagggattcggcccggag
1157 2912792 — NO ggatgaaatcgtgcacgtccctcttcgtccctctcaggacagaaattcttttgtccagcatatatctatgttgcatataccaccagccaattagtcacttagtagct
ggtgttggttatgagatcaactgtcatagtatcacagtgcttgtttcaggtaacccttatgttatttaatagtggcccaagagtgcaagagtactgttgctgacaat
ttggattcacgagaagc
1158 3590727 JMJD7 YES tctggtatgacatggaatacgacctcaa
///
JMJD7-
PLA2G4B
1159 2363028 — NO gaaacgccgtcctgcggaaacatccaccatccggacc
1160 2374733 — NO tagagactggatcatagaaggagttgtttgccatgcttacccttaaaggctttctgagcagtcatcctgggatggacagggcagggagtggagagaccagc
gagcaggtttttgttacggttcgagtgagggttgaacacaggcagtggtggtggagatgggttgcagggataatcttgagagagatttaggagacaagattc
acaggttg
1161 2448301 TPR YES gagattcagcgattgcaggaggacact
1162 2596900 — NO gaatggtgggaaatgtatgcttgactcaaaacagccag
1163 2713805 ZNF595 YES ctatatgttctcctttcagccaagacct
1164 3878694 — NO ggggtgtctgcgtggggagaaatcagttgtcggcattttaaatctctggataatgag
1165 2434634 ARNT NO cggctgttgatacgattgtctgttatcgaacacattcagtgataaagctgggttactgctgcttttggtgctctcaccttatctggaagatctgcaaacattaccta
aataggctggcaagataaacactttctggaacccgagacttggccataaagataatgctgcatttttctgtcagaatcacatatgatgtgtgttctgtagaggtta
tttctgcatggaaactcaacttcttggattagccgtcccagtgaaaatcctcattgttggagtgtaaaccaaatacgaagccctcttgcaaagtagcctctttcat
cccatactcaaaatacccagtttagcaagcaactgagatttaagtctctctggccctaagaggtttttcctctttgctccctccaatcttgagattgggttttgcttta
gagtgcaagtatcataattccgtatgatagatggggcctggacacccatctcaacagggtcacttggtaattaacaatagccatataaatgcggatacaggtt
actaccctcaccctttaccttcctcaggtaacagtcgtagataccagcttttttttttttttttttaaattggctttggccagtagctaaagtgcaagactgaattaatg
agaagatatattaaatgtagtcataggggactgaggagcaagggtggccttgaagaggccaaaggaatgtccatttgctgagtttcccttccttatgtctccag
tctggtgccaggtagtggagtaaaaaaggagacagtttatttttttattctatgtgcacacttacagtatacatatatatttatatcacaatttacgaaaccaaaaag
ttgagtttccaatggaacccttgttttttaataatcgactttttaaatgtgatcaggactataatattgtacagttattatagggcttttggggaaggggaggatagc
gagaagatgctctgggggttttgtttttgcttttccttcagggttttatttttgactgttttg
1166 2502158 — NO tgcactttcccagcgtttctgtctgc
1167 2511348 — NO agacaacagtaaagaaataccagcaatttgaagccctgtccctgaatcctactcctgttgccttcatatcgagagttccaagtgttggcctgcagttaagttctga
1168 2697262 DZIP1L YES ggaactgcatgaagagcacatggctga
1169 3829727 GPI NO gttctctgccaagtgctggccagaggcgcgtgtgttggtcctggtcccccgctttctcccccactgtcctgtccctcccctccccgtgcagctgctcag
1170 2566885 — NO cctacgaggtccatggcagcgggtacttgaaggattta
1171 2644609 — NO ggctttgaggatctctgtgccactttg
1172 2681773 FOXP1 NO tccttacgaggctagagattttctgacaacagtatgttagtttcatttggtccgtgaatggagatggcagcaaatattctcagaccctcccagatctggctaaga
catccccttatttaggaacgaccctcccctggcataccctactctccatcgcctgttggcaataaacgtgccttgtggatattccttaaaagccttcctgccatcc
ctctagcagtcactgtaaagttcaaatctcaaagatgcttaggagccaagattctctctgctcgtgcccagcagcccctgctgtgagctcactgccttccccag
cacgacctcctaggctgctgccttcctttctgttggagtctggagtcaggctaactcctaaaaatctgcagagaggtctctggagggaggacccaagcctgtt
actacctaagccagaattttacacctagtttccttgaatagagaagtccaaccccagaggtgtgcacacacacccgccctgcaaatcagtgacggggagaa
agcctgacttttcttgggttttgctagtgggggaaattgctcatttggaagggcaccagcaagctta
1173 2941811 — NO gtgtcgcttttattctaactgctggaactatttgttgtacctctttctgaagatcagtttggggctaaattacaagctccatcagcacaggggccatggctgcctcc
tgactgctgtaggctgagcacttggtagagcatcagccc
1174 3037970 — NO tcacctaaaaggacgaatccatctgcttctgtctctggtactgagggctttttagattccggaggctttctgaaga
1175 3235439 SEC61A2 NO acactttgacggatcgtttttgtcagatga
1176 3670576 — NO ccaaggtcacacaatacgaggtggggtcagaatgcaaacccaggcagtgtgcctacctagcccagactcttaaccactaagatgtcactaaagaagca
1177 2682104 — NO ggagatttggagtacttggagcatggag
1178 3809910 — NO gggaccttgtccctctttgcatggagggatggtttctttaggtcctgggggatagcccaggccacttccactctgaagatctgtgttctttatcagtctttcaatct
agtatatttgcatttaataggtgacaaatgggcctggaagctgtggtgggg atggagtgggaaaccagctctcagtctgacattgactcctggaggggagg
gtcacctctgttcctgggcagcctttcagtggcgaaggccaccatcccccacagcgtgattgagaagcctggcacttctgcaatgagtactgtggagcctga
cctttggctagtagcttggtctttattgacagggctgtc
1179 2428310 — NO cccgggtctgtcataaccgcaaatttctataccactctgctgctttaagatatcaacaggcaaaagataaccactgtccaactcacataaaaataggacatcaa
gttttgggggacttcatgtcctacctccagcttactaagcctgctatctctggagattccactactgcaaacctagttaggcaatgggtaatagcattacccatta
agccaaatgtggagtgaacaataataataatcactaggacttggagagtcactaaataaagatttgttgagtaagtggaggaaggctgccttctaagctgtgt
atcactttggccccaacctgcagtactccttcccactgtagccactgactcctgctcccagcttcaaaggctaggatcctctcataaagaattaccaaagccag
agatccctacctgcctaatatatactgatgcctcatgtgggcccttga
1180 2429289 — NO tgtggtttgattagtaactaccctggagtgtctcaacttt
1181 3246430 — NO acccgatgttgacagtttctccctccctctctctctctgctgtttcctctatagagctaagtctggtttgcattgaaataagcatgcagtaatatgccttttgccttac
caacttgtatttgcacacaggcagca
1182 3314235 — NO gtgtcctaagcgggtgcatgtccag
1183 2332841 ERMAP YES tggagaagagcccggttgcattttg
1184 2452077 PIK3C2B YES catggtgatgcatattcggggcttg
1185 2592323 — NO atagagggttcttgcagctgtccaaggtagaggcagtggaagcttgcgctcagtagaatcagtggaggtaggaagaggtggacagattcaggttatgcttt
ggatgtgataccaatatagaaggatccttatgttgaaggattagatgcaggagtgagagcagaaagtcaaggatggctctacagcagctactagaacccctt
gaaaaatggtaatgctgtacacggagctgggaaggcaaggagggggcaggggcaggagttttgtaggactcaataggtttgtggagagaaaaggaggc
tgatgggaaaatcaagggctttgttttgagcaacatcaagatacctattaaatattcaaggcatcaaacagtaaatgagtcagagttgtactagtatcaagatttt
tgatcattgttttattaatcctaatacaaaccttcctagttgtcagggttcagc
1186 2895598 — NO atgttctcggaacaaggaaccagtaaagtacagacatctggccccaggattttgctggctccagggacgtcactataaacccactaacactaattgctttcac
gtctgctcccatttcta
1187 3578431 — NO catgcgaaagcaacagtctgatctccaggttatgaaaactataattaaaaagtcactacacagaaaaggtccaagtttccagcttggcaaaacttgggtgcag
ttacatgaaacgtttaataaactgaattgttttccccaatgtgtaaacaaaatgacaagactaaatctgtgcctggtaatttcaatctaactctgaagctacacaaa
acacacagacaccttgtacatttcacctgttagtatgaccatcttttttcttcggtggtggaaggaagggcaaggtgactgtgtaaagcaaagatgtgggaagt
agaaatattgtttactagacattataaagtcatggtgaaaagaaagcttcgattaatgcatagcctaaggg
1188 3590373 — NO tcttgtggttccttaacttgtggcagcataactccagtcttcacatgaagttcttcctgtgtgtgtatctgagtcctaatataaggagactagtcatattggattggg
gtccatcctgctctgttaatgacctcatcttagctgctgacatctgtaatgactctattaccaaataaggtcacagtatgaggtagtaggggctaggacttttaac
atacgaatattgggaggacacagttc
1189 3277334 — NO tgcctgcttcacacaagtcgaactgcaactgggatcttggcttcttgtcaagtcagtagcatgcaagccagtttaagtcaaaagaggacacactcctcttactt
gattccccttgccatctattttctccctcaatcttagccacttggagaagaatttaataccttttttttttccagagtccaaaggctgtggatctaagtggggcattttg
tgctcaagcgaatctgccatgcactacggtttcaactc
1190 2323027 — NO gagcggtatcttgaaggtggctttaagtttgggaagttcgggaagagcagtaaaggcacgatactgggactgagcccagtaggagt
1191 2360843 HCN3 NO tgtcagcagatgtcttgggtcctgagt
1192 2834307 STK32A YES gaataaacaaaagtgcgtggagcgcaatgaag
1193 2890310 C5orf45 YES aagaagaaaacgtgggacaccagcaggc
1194 2510000 — NO gataatgaagccaacgcaaaaatccacgtctccaggctaa
1195 2575065 — NO tctttccagctcatgtctcccggggggctgggctgtctcctgtcctgcagccgcagcacttgatctcagcaggtggaatgcagagcagaggaatccgccag
acattacagggatctatctgagtataaaacgggactgctctttccactaaattgcttttggagaataaagttaagtgaattaaaatttccccagtctcaattgctaat
atggtaaatattcgcagttacaactctcattaacaaaatctcttaggagtcctcagtaatttgagactgtaaagacgtcttgatactacaatgcctgagaacgagt
tctctggatcttacctgcccctcttacatgaggaggcaccctgatgtctgggtggcttaccctttggcctctggcgggcattcagcatgagtgaa
1196 3336723 FBXL11 YES tttaatgtagagtatattcagcggggtggcttgagagatcctctgattttcaagaattctgatggactcggaataaa
1197 3660063 — NO catgctctgacgctctatgccactgctgcacct
1198 4029263 — NO taaaagactgaacaagaagggcacagtgttcacggagattgaagtgaacaagaaa
1199 2663789 CHCHD4 NO gatgaagatttggacccttccattcataatccctttctaagtgaagggagaggctggcttggctgttccttgttattccgaaagccctggtttggggcccatgttc
acactggctctcagtctagtcaggtgca
1200 3743045 — NO gccactctcgtgctgcttgagctgc
1201 2826559 — NO agcaaagactctcgggaacaccctattacaggaaaatctctcatacctgacctctgcttaacccactcgtgagattaaatgatagtcttcattctctctgtagaat
ttgctgactgatgctcatgctacattgaatgacagtagactattctttagttttatcttgaacttttattccccccagttactgtagacttaccaagaaacatttgtgttt
gtacccaacacactgttatggcacttgatgttgtaatcacatagtttaatgaattattattcagtgaactctgaagataaaaaggcgtttgtatgagaaccaattgg
ctactttgaaatcaagtgagtagccaaaatcaattatggttgaaatagatgagggttaaataattttaaatgattagggaaaaaaaaacaaaaaacacctaacg
atctaaaaaaatctgcaataatattatttttcacgtttgtaaaatgtctttctgtgtttaagaaacagaaactggaaatcacaggtgttgttttatgggggtagtttttg
caagaaaaaggaaatagaactttcttcgatagacccacactgga
1202 2882611 FAM114A2 YES gtgagccagccaagaattctgagtctgttgaccaaggtgccaaaccagagagtaaatcagaacctgtagtttccactcggaa
1203 3044784 — NO gacccacggcaattttgaatacttggaagagcagtctaagtaccctcacacaa
1204 4016017 ZMAT1 NO tgtaggtattcccatggtttcatccttgaccttactctacaaacacgatttctatttccctgatttcatttctcatctgtatgcttatgacctttctgtcaagtattagattc
acatatccaaatggcagctactgcttcacctggatgcctcatagcca
1205 2872559 — NO ttggtgatgctttatcgacctctgagaatccctttgtgatctgcagtgctactgtggttcacaaaatctgtgttcttgctctccctgatagcatctgacatttgtcatc
aggggttggcaatc
1206 2810393 MAP3K1 YES tgctagtgcaactactgctccatcgatcccttcacatttgtctcctggtttacgagatgtggcttcgttgtttagaacttc
1207 3309863 — NO aagtgtagcggcaggcatcctggga
1208 3349873 NNMT NO gaatgctgttagcctgagactcaggaagacaacttctgcagggtcactccctggcttctggaggaaagagaaggagggcagtgctccagtggtacagaag
tg
1209 3849058 — NO gtacatcattacccggcacagacaca
1210 2609601 — NO cccctcaaatcttacagctgctcactc
1211 3489275 — NO tctcttgattagtctaggtggtggtttagttctgttctgattttttatttgttttagagatggcatcttgcgatgttgcctaagctggactcaaactcctgggctcaagt
gatcctcccacgtcagcctcccaagtacctgggactgtaggtgtgcaccactgcacctggctgtctgctctgatctgcaccactgcacctggctgtctgctct
gatctttattatttcttccactaattttggatttggtttgttcttgcttttgtagttcttgagatgtgcattgctagattgtttatt
1212 3490771 — NO tctccgtattgcttagggtggtctcgaacttctgacctcaagcagtccttcggccttggcttcctgaagtgctagagttacaggcgtgagccacagcacctggc
ctacatattacatttaagtctgtgatgcttttagaatttttatgtcaagtgtgagatttaacttgaggttcctttttgtggggtggatagtatgttcgggtgttctggcac
ctatcttttctcattgaattgatttgcacctttcttaaaaatcagttgagcgtatttgtgtgagtctatttctaagttccccactgtgttagattgagctgtatgtgatcta
tatgtatgttcctctgtcagtcccactgtcttaagctgtagctgtttaagtctgaaattgggcagactcattcctcctacttta
1213 2353513 — NO taatgtcatcatcagtgggcaagtctagaaccctaatatcctggtgctcaaaattagtgttatcaattcagtcttctccacattaaacaatttccaattcctttgagg
cctggtgtgatggattctgtctttcaaatgctttttttctttcagtgactctatcgttcataaatgttaaataaaaccctcactctgttataaaaatatagactttaaaaat
tttccaaagtaaacactccagagaaaggtaggcgggctgaataggctgctgttgtccttcttactgccca
1214 2610157 CRELD1 YES catctgtgtgaaggagcagatccca
1215 3092298 LEPROTL1 YES tggggagcttgtgcacttgttctcacaggaaacacagtcatctttgcaactatactaggctttttcttggtctttggaagcaatgacgacttcagctggcagcagt
1216 3241630 CCDC7 YES taaagaaaatcgaccagaagcagtgaaaagttg
1217 3489976 — NO ctctgaggtttaggcctcgatattcaggagagtggtgtaggaggaagatgaaccactgggttttagacacatggaggcttagttcagggctttgggcctccc
ggttagtttgtttagtcttgttgatctaggaggagatcacaccagatga
1218 3671050 PLCG2 NO ggagaacgtgccctattcacactctgggaagacgctaatctgtgacatctttctttctcaagcctgccatcaaggacatttcttaagacccaactggcatgagttg
gggtaatttcc
1219 2476149 — NO gtcagttagacagagtccacaagggagtcg
1220 2670672 — NO gaactcacggtcttcagccttcctgc
1221 2792848 — NO tggccatggtgaaacagtgcctcta
1222 3168127 — NO ttccaatcagcagtatcatggattaaat
1223 3227785 — NO gggcagtttgactatgtcgcatccagcttcccatgccgtccatccctaggagtctgtctcaccatacaagggcgcagacaggccagcttgagggtgttcatc
aacgcagcattgtttgaagagcagaagttagaatctattcattcgggggcctgactgcataaatacactgtggttgccgtccagca
1224 3367153 — NO cttgtatgaccctttgtctcggttgactagttgtttgctctaagaatatttcatgttttgctgtttctttcagtttgtaggtgctaagctattgaaaggtttagagactaat
ctaggtctttctaaattatggctgcttgcagttttattcctggagaaatggtttaacagcacttctttgagttggcactcttctgcctgtctcagctctaactttcccgc
ctccttttcagtagtccctctttcaccctccactccccaagcctgaaatggaaagaacttgctttgttactgatgataatatttaagctctaaaattttaacagtgttt
cagttgcaaataaatggaaattgtgtattctgtttaatgtgtttcagaaaatccctgctattttttttttctttaaatacaagaaaacaggcgtgtaatgcctcattgaa
aa
1225 3483227 — NO tttagtcaagtaggttgagagcaccagggatcattttttcttcacaaccttttagctcagtgatacccagagcaatgtgcctactcagtggagaagatagtatttgtgt
gaataaatttactgttctgtgtgttacatgtctagttaggagtggtcctctaattctgta
1226 3766878 POLG2 YES aaaatgtggttccttgtgttctctctgtaaatggggacctagaccgaggcatgctggcctacctctatgattctaccagctg
1227 2555150 — NO tgggcgtgaataaggaagcaaaactcaattataataacattactattgttcaaacttcacatggcacttgcaaccggaggctactttgtctgcctgtctccatact
catgctgtcttatgctcatgttcttca
1228 2601747 DOCK10 YES gataccacttcccactcgtcttccaaggggggtggaggagcgggaggaactggtgttttcaagtccggctggctctacaaggggaattttaacagcaccgt
gaaca
1229 2664745 — NO ttatccaccgcacatgaaagagagctcagcgccaactgccagtccactgaagggtgtcgcagtgatatttgtttga
1230 2698409 — NO atgtgctactaacaggtcaggagcccagatcaaagagctggtttgggaggtggataatgaaggttgtgaagtctgtgctccctctgagaagcctgaggaaa
atgcaggtggctccctcaatcaacagacatccaaaatgg
1231 2704917 PHC3 YES atcagcagattcctcttcattcaccaccttccaaagtttcccatcatcagctgatattacaacag
1232 2823922 CAMK4 YES aaatgggattgtccatcgtgatctcaaaccagagaatc
1233 3717013 — NO ggtctatatgtctgtacttatgctggtaccac
1234 3498270 — NO atgtccagcgcaaggacactgtccagccttctcttcctgcacatcagctgcctcccgtcagtcctgctgaacggggatccttcccagatttc
1235 3737381 — NO cttcaaagggtgtccagatgctatgaagcattgggttcgacttggggtccacgtggtttgtgcctcagggtccaaaaccacctgcattctaccggtggcgtct
gcagaagacgaatggcttgaaggagctggcactccgccggctagatgatccaaaccatttcatttctttgtcgtgtggaaaaggccctctgtgatgcacttct
gttctctgga
1236 2512319 LOC643072 NO ctgtagctttgagtttgcaccgttccttgtcccaggaaaaagttaagaaacttaaaatgttttgttttgctttaaagaagacaggacagaaaacgggatttaaaa
cttagtttttaaaaaaacaaaagctacagagtagggagcataggtcaaccatctccacctaaattttttttgttcctaaactcagaattctacaacccaactaaatt
aatatgccaagattttgcggatgttaaaactcaaaaaaagcagtatgcaagacggtcccggggtaaaattctactgcctttccacggacaagtta
1237 3596425 — NO agtcctcgctgtagcatggggtaaagccaggatatgacttcacatagtttaactccagaacttacactgtcatcttgttttgtttttctgttctcttgtgtgtcaaaa
gaattcctccttagttgttctcatatggggcaaccattaaattaggcagtgtaaaaaacaagttatgcagaataaagtagcaagagcaatctactctgaaattag
tgttttccctcactttagcacctttagctgacccagcttcctaccgcccagactttttacaaaatctctctctggagttgcctcctgatctggattaggagtcacata
1238 3809494 — NO ctgtgtttaacacggctgtgctacttcaggctcccatctcgctgagggtgcccatgtcagccaatgacctt
1239 2442446 — NO gtcttttgcagtaggtcagggctaagaggactaatccctcaagagtgaagaaaaaaactattgatggtggcttgaaagagtcaactgctgtagcttttcttgga
gatgatcacaaaatggggagcagaaaacaggttgaaattacagaagattaattagtaagaaaagatgggttaaagatgtaaattagaggcaaagttaagaa
gaatttggtttcttcattatactcagaaaggtaaggatggaaaagttgatggagcaagattgtgaagtatcttatatgcaagactaagaagtttggactagattct
gaagacttaggagaaccagtgaagaaatcttaatagaggaatcggattagatcttagggtcagaacaattattagcaagcagggtaggtgaagttcctgttg
acccactttg
1240 3281111 — NO agcatctgtcgctggtgagaccctcaggaagcttcactcatgaggaaggcagtagggagctggcatggcttggcgagaggcaaggaaggagagggga
aggctcttttccataagcagttctccctatggcaccaagccatttatgagggacccacccccatgacccagtcacctcccaccgagcaccacctccaacattg
gggatcacattgcaacatgaggtttagaggggacaaatattcaaactgtatcactgggagatggggctaccggaagtcaagccattcc
1241 3770080 — NO ctgtactaagtgctgatgtgccagcgctatg
1242 3821078 — NO acagatgtgatcaaaaggcctaatatatgtgtaattggagtcccaggagtgaagagtgaaaatgaggcagaaaaaaattcaagtgagaatggctaagaattt
ccccaaactgatgaaaggcatccacccacaaatcccaattttgtacttccaaccactgttataccacccccctcaacaatgcctataaatgtttgttgaaaatga
gtgaatgaatgtactccaatcattttctcacttggatgttccctactttttgc
1243 2531265 SP140 YES ataatagcaaagccgacggccaggtggtctccagtgaaaagaaggcgaacgtgaatctgaaagacctt
1244 2719554 CC2D2A YES actggtggctcgatatgtgtccttgattcccttcttgcctgacactgtctcatttggtggtatctgt
1245 3342924 — NO tgaggtccacaaatcagtcaagttgaataaagaggaaattctaaggaaaatattaaaaattacagaaagaggaagctggggacactgagcataaactttgat
gacatcaattttaccgtgtgcctatccactattcctccacttagtttctcagatcttgccagcaaccttagggcttgcatcctccatttc
1246 3811421 — NO gtacgtgtgagtgcgctgtataaagtctggaaccacaattag
1247 2448106 — NO ttgtgtgattgcaatgctgaatttgtc
1248 2661177 — NO ccttgttcccacatcggcacattatc
1249 2748212 — NO aggcattttttgtccacacacttgctttggggatttttattaggtagacggtaattagaggtgtcagtcatatgaaagtaaatcactagtctttcgtattactgttttct
cagtggtccttatcagttttttttgttgctctgtaatcattcatatggtaagacttaacttttagtcatgtaaatttgtttagggacaatttaaactattttgtcaaattagtc
gttttattccaagttgtacgtcttatgcatttatttagtatagtgaaagccttatatacacatttaatataattagtctctggatatttggattattttttagtagtactttttta
gagtgtgggttttttcttttcttttctgtttttgagacagtgtctggttctgtcacccaggctggagttcggtagcccagtctt
1250 3081649 — NO cacctttgtgcatgtatatacttcaagttgtatgaatttctttatgcaaagagcctttaaaatataaactgtgatttttgtttctaattttttactttggattgacagggcct
tttttcaagtgttggaatttccttttagatttcttatcagagtttatcttgattttactgaaattcatttagctatatgaaattcctttagccatagtcttgattcagatcccc
ccacctgagtctttccaggaccttgtgccatctgttattgccattgttgtattcacttacagcctcttctccatgagtacaagcccaccatcatgctc
1251 3415065 — NO gagccattcctttggcaactcttgctgtcagccatcttccaaagagctttg
1252 3436225 — NO tgtctaccatgttgggcagcacagatctaaagcatttagaaccatggctagagctatgtgtttactatcattgcttcaatatggagagtcatccaaacaggtttca
tttgctcccagataaactgtcatgggacctgccgtggccagtgctcaccttgtactgctggaataatttaacaatttttttcaactgccatcatcatcatgccatttt
atgtcttcgtagcatttatcactatctaaaggtaggtcgctta
1253 2546677 — NO ctcccaaactcttgaggacatgtggggaactacagctgg
1254 2723423 — NO aaggtagtgtgcaaagcgaaaagagggcacagaccaaaatcatgcaaaa
1255 3291647 — NO gtgggttacatgttcctgcctggca
1256 3449366 IPO8 YES ggacctcaaccggatcatccaggcgctgaagggcaccatcgacccgaagttgcggattgcagccgagaacgagctcaaccag
1257 2935290 — NO gttttacaacacccaaagcaacagaaa
1258 3296065 KCNMA1 YES gttatggtgatctgttctgcaaagctctgaaaacatataatatgctttgttttggaatttaccggctgagagatgctcac
1259 3414403 SMARCD1 YES tacggtgtactgtcctactgatgctggattacca
1260 3611215 — NO ctagtctagggatagtggtagaagtacgtaatgtagatg
1261 2997513 — NO cctttgctctctcatatgcatccggcacagcagc
1262 3180413 — NO ttcaagggcataggcgtcggaattgtgatttcgtgcgtgttt
1263 3732510 — NO gaaccactttgttgaccttctgctgcaa
1264 2572597 CCDC93 NO ctggacggtgtctatcaaaagtgcaaatgcataagctctttgaactagcaatgctactcctaagaattgtacctgtgtacaaggtacttgtgtacaagagtttttgt
tgaaacattgtaatagcaaaaagttggagagtgccaccaatacaggggaatggttaaatacattatggccagcttaaacaatggaatagtttgtagaaatttaa
aacaatggatcctgtgtgtgtgtactaccatagaatgggccccaagatgcatgattaagtgaggaaaaaagcccatggtatcctaatgtttggaatggagaaa
gtgtgtagatgtatgtgtgtgcatatgttttcacacagacgtatacacgtgtatatcatatgtccacctgcatatgcctaggatgtctctgggaggatatctagca
gcccggcagcctgaattgcctctgggaa
1265 3216409 — NO aggttctgaagtcccaggcaaatgtaatagggggtaggcagaggacttacttagagagatggtggtgaaagtctcaaactgcagatttctagaacaaacag
gttacttgtaagaagcagacagagatacttagatcagtaaaatacttctgtaacactagaagtgagaagacatgagaacgttatctagaaactatcaagagga
aatgactgcagaccaaaaatcctacgc
1266 3294290 — NO tccacagctcgatttggccaatttcgagttgaaaggatggtactggacccaggcctcataagtagcttgtcatcaagatctctagtagccaaatcagaaaccc
acaatgaagtaaagatcagtatgtcaaggaagacaagactaacggggtaaaaagccttagactagaaactacatttagggggaaataaagcaaaaataaa
aacctttcaataagtaacactagtttccagatggtactctagctcaggcatgagaatctgttcttaaaagtgggacattatttcaatcataaacataatttactaga
atggacatttggcaaagcaagtccattatccacctgccatcacagtcacttttttagtcaccagtgaaggcaagcctgaaggacacctactccaaagtgcttcc
caaaaatttgccacaggggctgattcctactctgtttgaggcattcttttgtgctgaaagattgtcaccagaaagacaactgaaagacaaatattgctgcttggg
agcagttgtggcaccagtgtggctcccactgtagcaattaaag
1267 3446505 — NO gtcttgtagcactcaaacctttgtctttcccacaagactgaaaactccatgacacaggaatatttcttatcctgtgaacctttgtgtcataccacctatagtagtgttt
agtataaaataaattaattgtttggaaatctatcctaaaaaaaaaaacctagattcagtaaaagctctgtggccaaggatgtttgtgttacagtgaacaccttcga
gcacttcagg
1268 3616936 — NO ctcatagcatggtggtctcgcagtagttagccttcttacatagttactggcttt
1269 3628351 MGC15885 NO cctccgttacccgtcagcccagcatccggctttgcttccataa
1270 2745112 — NO gcaaaattggtctggtatctgtctaaattggtcaatacaagtgttattctggaatcatgtaaaaatcacttactttcataactgtttagaaccccaaatgttttcccttt
gaaggggaacatctgtggaatatgattttgaatagaggacttctatgaaatatatttcaaatcttaaaaatatttttaatacttcctaaagtggtataggatttaccct
cgctgactatgccttccatttaagaacagtcttgcatttgtggcttttca
1271 2824232 APC YES tgtccctccgttcttatggaagccgggaaggatctgtatcaagccgttctggagagtgcagtcctgttcctatgggttc
1272 3101817 SGK3 YES agttctggtttcagtgggaagaagtg
1273 3129414 — NO cctagctgtctgtcaggtagaatgagggtgaaggagatctaggatgcttcaggcattgcgcttgaacttaaaaaacaggatcagcaggccctgacttcataa
ggcccataaatacaaatgactagctccctttctcaaggtcattgaaaatatacagtagtttcagacatcacatgggtttgggcaaagggggcagatttccaagc
taggtcacttaatggtatc
1274 3576514 — YES gtggccgggaggcaaaacttctctatgagtggaaacgtttgaagaatacatcacccattacgattttgctaatcttaggtttcagacaccacagacacattgatt
ctatttggaaagatagccatcaatcagccagc
1275 3650814 COQ7 YES ataaagaaatttcgggatgaagagcttgagcaccatgacataggcctcgaccatgatgcagaattg
1276 3723777 — NO gccaaagagcatgtagagcaaactaggctctattcagcatttccatttcttaatgtatctatttgatttcaataaaatttcatcattttgaagatctctcccattagctt
gggaaactacagaaacatgcacataactactgagaaggtatcaagtgttcctacactagtttaaaaaaatcattcaacacccacataaattctgatatgcacta
ggctgaacagctgttaaccactgagaagctgggcactgcatcctctccctgggtcaaaactctatatgct
1277 2550931 — NO atgcacatgggacagtctaagatggtagtggtgg
1278 2681842 — NO accaagtgacattttgcattcagcctt
1279 2868846 — NO gctctagtgccacaggaagctgcct
1280 2880139 PPP2R2B NO agccaagggagaacccaagacagagaa
1281 3309073 — NO attgaatgattgtttagaggcagtgtga
1282 3636536 HDGFRP3 YES gcaattcagcaacagagctcttcagaa
1283 2347802 RWDD3 NO gggatacattcaggtctcagttgttgaggctgttgagcagcaatccaggtatgaaaatgggaaagatttgactgcttctctcatgcaggggaataaagcaaag
gc
1284 3202177 PLAA YES tcctgcacttgacattcttcggttgtcaattaaacaccccagtgtgaatgagaacttctgcaatgaaaaggaaggggctcagttcagcagtcatcttatcaatctt
ctgaaccctaaaggaaagccagcaaaccagctgcttgctctcaggactttttgcaattgttttgttggccaggcaggacaaaaactcatgatgtcccagaggg
aatcactgatgtcccatgcaatagaactga
1285 3945822 — NO aaggaagcgagagacttggcagtcctgtaggctttaatggaatcagcaatggacgctcg
1286 2682207 — NO ggggctttaattcttaatcgctgtgaggattgttatccgtgggatgtgagctgtcttagtggtattcaatcaagtgtccacttagccatgactggaagtaattgctc
ccaagtgggcc
1287 3263773 DUSP5 NO agccattacgggagcacagcatgtgctgactactgtacttccagacccctgccctcttgggactgcccagtccttgcacctcagagttcgccttttcatttcaa
gcataaggcaataaatacctgcagcaacgtgggagaaagaagttgctggaccaggagaaaaggcagttatgaagccaattcattttgaaggaagcacaat
ttccaccttattttttgaactttggcagtttcaatgtctgtctctgttgcttcggggcataagctgatcaccgtctagttgggaaagtaaccctacagggtttgtagg
gacatgatcagcatcctgatttgaaccctgaaatgttgtgtagacaccctcttgggtccaatgaggtagttggttgaagtagcaagatgttggcttttctggatttt
ttttgccatgggttcttcactgaccttggactttggcatgattcttagtcatacttgaacttgtctcattccacctcttctcagagcaactcttcctttgggaaaagagt
tcttcagatcatagaccaaaaaagtcataccttcgaggtggtagcagtagattccaggaggagaagggtacttgctaggtatcctgggtcagtggcggtgca
aactggtttcctcagctgcctgtccttctgtgtgcttatgtctcttgtgacaattgttttcctccctgcccctggaggttgtcttcaagctgtggacttctgggatttgc
agattttgcaacgtggtactact
1288 3497166 — NO cgccagcataccagctcatgtttcagaatttctgtcacaaaaaggaacacaatattttaagttgactactgtgggaaagctatgatcattcaataacctacctttct
gatagctctttctcagataatataagctataaaccaaaatagtcagccttcacctgatttacagtgccctttgaaacttcctaagttttctagcccagtaaatgctga
gctaccagttctacttccaagctagagaacctgtttactaaagttagaagtctagtgacttcctctgtcagactgtcccagaatgctctccctacccccaacaact
gtgtaagaaccgtcattagccatctccaaattgccaaagtgctcagtcccttcg
1289 3618874 — NO gtaacatgcatctgtgtgggaacct
1290 3202840 — NO tttcactgctactgcgaactggtcctgaaggtgcagatctcttagaaggaggactcccacttcttggtggtggtcctctttttactggatgtggtcccctggaag
aactcatgttaaaattcatggaatatccaccgtcatccatgtgtcctccccgtgagggaggtccccttgttcctccacttcctcctcttccacctctaagacctctt
ggagggcctctacttcttggaggtggaggcggtccacgtctaccactttcaaatgatggtttgttggcttgttccacctcgatggcttttccatctaatgactttcc
attcatgtctctggctgcatccttagcatctgctgggctttcaaaggtgacaaaagcaaatcctcctgatttgttggtttcatggtctttcaccaagagtacttccac
tattcgtccatatttgccaaatactgcttcaagagctttctcatttgtttccgtgttaagcccaccagtgaacggctttcctgggcaatctgc
1291 3755656 — NO cattaggggaccctgcctgaatctttgccaacctgcaaggaaactc
1292 2469949 — NO tgccagtgacatccagggttattcgtatacctcatgctttagattcgcttctggttcatggtgccagcccttagaaactctgggttcctacctgaagccggtcttat
caaaacgccacccctggttccagtttgatcagggtaaccttgtgaattagcaagcagcagtccccagtgtgtgctgacatggaggttggagagaaaatagat
atgtcccatgcctggtttccagccaatactgatgtcgcgggttagtccagcaggctgaggctgaggcctgtgacaaagtccctgcatggaggtcttcctgcgt
cagagcctagccctgttcaata
1293 2830605 — NO gagctttctaatgggggtgggaaga
1294 3235906 — NO ttggggttgatacccatcatcgctcttagactcggggttgatactcgtcatcgctgttacactcagggccgatacctgtcatca
1295 3616555 — NO aggcagacatcaaccctctaagacatttttttcctatcctctgggaatattactttttggacaatcttggtccattggtaagctcatgggaatttgtcagagtttttttg
tttcttttggctcatgtttagcatcgattggcagagtgtttggagtcatcc
1296 3369121 ELF5 YES caggaattttggagcgggttgaccg
1297 3908978 — NO tcccatcagcaacatccgtcataccctgacgccc
1298 2338495 — NO aagagcaggggacctatgatgcagaaagtcctttgctggagctcacaggtcgaatttcagggaagctgcccaagggcttgaacatccctgctttcaggttcc
ag
1299 2452931 — NO ccacatagtacggtgtataacaaggagtggtcaaagagttgtggctggtggtttccttggcaaagccaaagtcagtgagtttcaggatggcgttgggcctttt
ggaggtgtataagagattctc
1300 3448040 — NO tgttaagccttcctgagatcacaccaaatgtccttgatgggaattgtaaacaacccttacttctggtttctaatgatattccaggaaaggagcctaactagagtca
1301 2823916 CAMK4 YES gattgtggaaaagggatattacagtgagcgaga
1302 3799998 — NO gggcatcaagaatttggacatactggtgtctggtatcgaggttcttcagctactcaatgcacgtgatgatggtgatgatcatgatggtaacaacagac
1303 2978095 SHPRH YES tcatgaatattggatggctctgaggaatcgtgtgtctgctgttgatgaacttgcaatggctacagaacgactaagagtgcgtgatcctagggagccaaagcct
aatccgcctgttcttcatatc
1304 3475634 — NO gacacctcaggtgacatgctttatagttggcctgagccttgacccagtggttcaacctgagtttggtcttggtaccattcaggtgtttgtgagctgagactgatg
agtaggaacaggtgttttatatctcgtcttttgtcaaaagtaaagactcattcctttggtaacccaaccaaatcaggatcag
1305 3683092 SMG1 YES gtattctgagcacacccaactacag
1306 4022048 RAP2C NO cgccaagtctctgggctattttttatttttgcaaatgtgctttctaatagccattgccaccatgttgtttacctaatcagcatatttttgtctgaatacttgaacattttaa
cagtaacgcaggtgtagaatcagaaaggaaacttatgcagagtaatattttggttcagttttaacatcgtgacaatgagggctttttctagcaatgatttttaaatt
gtgtaagtttgacagtattttattgttgggtttttatttgattttagttgtgtgcttttcatttgcagaagttagtaactgcagctcacctactgcaccaaagttctcgattt
taggagcccagctttagtcatttgaacatgcttctaaataaaataaaacaaaaccaaaactatacttttgatctataataagagctcaataactttgtcaaggaaa
gctctaatatatgcagtgatggtttatgaaagggtgtggcaattttaaatttatattgtgtgtgatgttcaaataaagtggtatctacattcatgtgatttatgggtca
gcatgaccattaattactgagtagaaattgactaaactttgatttcctttttttaaatcgtgttgcatttgattcctgagcaaattccctcaaagtgaactcttgttctta
aattttgaattttatggtgagattgtaaagatagaggcaattgaaacattgttccttatttatgaactgcttgaagtgaatacttaatttaagtttgcactttaatacca
aacttaaaaccaaacactcatttaaaagtaggttaagtgatcatggatcattgttattagctttgtggctttgtgaaattctaaaggaatcaaataattcatcatgatt
taaattttctagagattttgatttttttataatgtttctttcctgtagattgtgttcttgtttctctctctctctctctctctctctctct
ctctctctctctctctctctctctctcaaaattacagtgttcattgtcattgacc
1307 3153356 — NO ttttctgaggaatagggctcaatggtgggcttagaatattgagtacaccatgctgtaaacagatatgctgtcatctaggctttgttgtaccatttagagagcacag
gca
1308 3529618 PSME1 YES gtggatgtgtttcgtgaagacctctgt
1309 3830025 — NO aattcattcgcctccggtacttgcaagcctcgctcagtcttaagcaagaggggatggattcgcccgcagcactgagaatccaggggcaggcgggatggcg
ttcaggcgctgttgctagaaatctctgtctttactctgttttgaaggcagcatggcagggtgaacacaagcacagactgaaggcagcttgccgcggttcacat
cctggtcacaccacttcctgaccatgtcacgtgggcaaatta
1310 3866580 KPTN NO agggatgatcccattccaccctgtccactctggatgagaattggccacctgatggttatttatacgtccagaagaac
1311 2620390 TGM4 NO gccacctgctgacgacccttgagaagctgccatatcttcaggccatgggttcaccagccctgaaggcacctgtcaactggagtgctctctcagcactgggat
gggcctgatagaagtgcattctcctcctattgcctccattctcctctctctatccctgaaatccaggaagtccctctcctggtgctccaagcagtttgaagcccaa
tctgcaaggacatttctcaagggcca
1312 2693884 — NO cagtctgagttcctgcacccttcag
1313 2724817 — NO gatgatgctggacaaactgcaaatcctgaacttagagactgttgcagcaataaccattttgactgtgataatatcattctgctcaagttg
1314 3718581 SLFN5 YES ccagtgacccggaaaaccttcatgaaaaacaactttgaacacatccagcacattatcattgatgacgctcagaatttc
1315 2645299 — NO ctggcagcctgctcaacactttaaattttatcagtttagtacctgctgatgcgtctaaaactgttggtcccattctagttttatacttacatatgtagtattaaaagcac
ttaagagaaatgtagaatatataatctttataaaagtattaaaggaattatttaaattgaatttgtatcccatttatcttgcttgctaaatagatttaattggagcatcca
tttgtataacgtctggctatttctacaatgttaaaacagtgggttgaggaagtaaaatttgagttactcagttactgacatagaaaagaaccctgtgagaccaaat
tcagctttggaaacaatttagtgtaattattttgcatatgtagatacacctttgaaagccaagaaaggtttatgattggatctgtactatattaatttaaaaacaaatta
ttcttaagtatattgtagcatttctgttcctgtaagtactttactcatcttaaatgtactgatcattagccacctttataaaaagaatgtgcctgacccactagtatttga
tagaaatattaaaacagttaagatccttaaacatttctgcatataattttttattgagtaaatgtaacttaacgtaagtagttctatgaagtctgtgtaaattaaaaccc
tgttttgtgtagatgaagcaatctttataagtttctgtcatcaagactgtattttgtgtgctatttttccatagctaggaaggtggcaagtaaaacatatgcactatcct
agaaacatactgttccaggtagatcttaatttactacctggaatgagccatcttaggtgaccacca
1316 2927067 — NO aatctgtagttgtaatgtagccttctacctaaataaaagagatcctaacataatggttctcattacttaagcctcattatgatcaagctcttcccaaataatctgacc
aa
1317 2434911 — NO ctgagacgatgattagtagaactgagaagtgcccattggttttggtgagatagaggtcagacattaccttagcactttttggg
1318 2916250 C6orf162 YES ggctcagaggggtgcgcacaacaaccttat
1319 3152957 — NO tctggcaaaacccaggtgcggtaaccctgcagcagcttccactcactcctgcaatgcctgaca
1320 3190622 SPTAN1 YES gaagcttttgagacagacttcaccgtccacaaggatcgcgtgaatgatgtctgcaccaatggacaagacctca
1321 3508990 — NO ggatttctatgccacactacccgtaactttgaaaaataactttaggctgcagttttcagcaaacaggacagtccttagctgccacatagctcaacataaagtgca
caaaaaacttcacggtgggacagtgaatcataaattcccaaactgacgtgtgtctacagaacagatg
1322 3567717 — NO ttttccatagcttggttctcaggggttatagatgcaagaagttcctggaaagagctctaaaccagaaaataacagtctgctggtcaaactcaaaactgtcttggt
tgatatatgagctggctgtctttactgttacctcctgtcatgatcattttgctaattttctgctataactagaggggaatgtc
1323 3780094 — NO tgcgttagaagacctgccgacaggccggataaggccaatgagagagggaacggagaagaggggcacctgggttcacaggccttaagaaagaatttagt
tacttatttaacaaattaaacaatgtgtgtcacgcatgtaggtctgggaaatgcattattaaaaacacacagtgcagaggtgcagcaccagcatacgggtgga
tt
1324 3799938 — NO ggacaccctcaaccagtaacacacactctccttcttcaatgacgtttgtgttcctagaatccattttcctcagtcag
1325 3932154 — NO tcttgccatacccaagtagggaatcacttccaggaaaacaagtcctcaagcactcaatgactttgtaaacccatgactgaaacaagactcatctgaggcagta
ggactggtgggattctactgacttcttagtatcacatggcaccatcacaaatgcattgttagagcagcaacatccagagttcttaagcttgtaccctaaca
1326 2534308 — NO cctcacagtgacacgcgatgttttcaaaagtccatctttccacaggatgtttacagcacccagcgggtaggcagtgctatttattaaccctgttgtactgatgaa
caaaccagccggctcagggcagggggtgagcttgatcaagatcacagacaggaagtgacagcggggtctcagcccaggccatgcctgacacccacac
tcttctctggtgggggcgcttccacctttgtccctggaagcccagcctgacagcttctgcagtgcctctggcagccgcccacaaacccagccaggcaaaat
cccagggtgccagacaccaggagaaatttccaggggaatttggccatttggctgtctcttcacttccctgaaaagccaaacagagaatggatttcttatcaca
ctgtagcaaggcaatcaactggaaaagagacaggaggagaagtgtgaggaccaacagtcacagggacccaggaatcgtgttagccaca
1327 3696944 — NO gctcccaaggcccaatcagatacagctctccaaacctgccagtgctggtgaacgcgctgctgggagcact
1328 3712853 — NO ggccgtgaaggaagaatgcggtgtt
1329 3916807 — NO ttcaccaggatacgactgttggaccagctgctggagatggacctgctacccctcagcagcctccccaccacaagacaagtgatctcaatgtccccaaacct
gtgggaccctgttctacacacctcatttttgttccggcgtttcatcctccttgtgtgattgtactgattttcatgagacacaagttacttctttacatccatattcccaa
agcagggttacatggtaggaaagaaaggaagttggaggtactaagctcattgtgtctcctc
1330 2381295 — NO aggaagtaactagagccggcatttgggggtgttgcggacgattcttacgaatccagacaatttgctcttttaaacgcggccttgcggttgtctaacagtgaga
atagatgactaactgaatttgtcagactccctgccttctgtcataataacgacgcagaattgccaccgttatgtgtc
1331 2608169 — NO gtatggggagaacgaggatgtgata
1332 2363544 — NO ccacaagaagggctagagaaatacagagatatttgaagagtgtgaggaagagtattaacacaccagttttcttgatcaatag
1333 2407863 — NO acatccttcttttcggccttgaatcctttcttgctttgcaaggaacaattttcttcctactataaactacagcactaaggtatggaccttagaaattatatagtctaatt
ctctgctgacacacaaatcccttcaacaacaaagaatcataagttcacattgaaaggtctctccaaatctcccataaatctacaatattcttgatgtttaaaattta
ggataatagagaattcactaattcataagacaaagtaccaatgtaataattctataaaatgtcataatctgctttccttgtaacttctgcctattgactc
1334 2920969 FIG4 YES aggatcctcgggcttatttcgagcggtttcagcttttggtg
1335 2949119 LTB YES tgcgtggtgcgagtgcgtgaatattgggggcccggacgccca
1336 3241194 — NO cattgggccttccatcatcagaaagctcctcatgccacatcttgacacattattcccgtcctcctg
1337 3447084 — NO aggatgtgagactgccgtggatatcagggaagggagacttataagaaggagaaatttggtcaactgtgtcaaatgcttcagcgatcaggatgagtaatgag
gaacggccatttgatttgatttgatcattcagatatctttaaagacctttaagagggcagtttcagt
1338 3626136 — NO acgaccatgcgcactgagaaacaggcaccaggatgtcgagaacggcaatgtatttgctcacaaaaagctctacttcacacaccacctgtgcatgagcgtgc
cacatcaaaatga
1339 3800039 — NO cataatcaggtcctctgcaagtgggagtccaactgtgacgcagcccccccacgttcaaagcatcccttcagcttccggcaatctcctctccagg
1340 3887175 — NO gccctggttgcaactctgctggtct
1341 4011861 — NO atgaggggaacggtagctgacaatagcagaggagggttttgcagggtctttaggagtaaaggatgagacagtaagtaatgagagattacccaagagggtt
tggtgatggaaggaagccacaggcacagagaacacagaatcactttatttcatatgggacaactgggaga
1342 2320367 FBXO44 NO ggtacaatggcatggcttctgtctaaggtacagaggggttggcatttcaggaaccaggccatcacagaaacaggttcatgggcagacccctcagtgagctg
caggtatctcacctggcagccgtccagtactgctggcttcctctggaggcccagccacaggctggggttggggtgtgtggacatctctgggcagctcttga
gtccaccttgtgccagatcagcagtgccaccc
1343 2680360 — NO gagctgggtcagttgctccattatgtactttggtttgcag
1344 2866718 ARRDC3 YES actcgctacctcattcgaaggccgacatggcagtgtgcgctattgggtgaaagccgaattgcacaggccttg
1345 3251759 — NO gacaaccttcaatgcactggtactttgtaccctgacctctactgtgatgaacactcaacttgggcaagga
1346 3742688 NUP88 YES tgtgttgagttggagcttgctttgaa
1347 3772092 LOC100131096 NO tggctgtgcctctcgatgatgattaagatttcaatatttacagcaaaaccacaaagcaaatgatagaataaagcaaaacaatggaaaatctgagttcactcgtg
agagaggtacgtatgtgagctctgaggaaattacagagggaacgcatgcagcgggacagctctcccaatcgcagcgtgcaaagtagacatcca
1348 2596545 — NO gacagcagagctatctatcagttcctctgaacttgttctgaatgagcttttcttactgttcagtattcactctcctattactgttttgcttcctcatagaattccagatta
gtgggcccctggaagttcagctggtagatgagaaaactgagcccattgaagttaaagtcacccagctagtcagggttgatcttcccaactcagagtcccctg
cttacttaaacttttatatccaacaggtttacttcccctggaaacttatttggtattttttattttccatctccatgccctcgataggtttc
1349 2928626 — NO cagccgccaaagacgcctgagagcggcaggggagtgtgttgccttaggacaatagcaaactgggacgtggtagagtctgtaaattccaagcactggg
1350 4035053 — NO catggtatcatgtgcctgtaatgtc
1351 2487210 ANTXR1 YES cagggtcaagaacaaccagccagcc
1352 2891955 — NO ggcccttgacaaatgcctgaaatct
1353 3061185 ERVWE1 NO ctcttcaaacaacaaccaggaggaa
1354 3104349 — NO atggacaagttaggccctccacttcgaacgggaagacttgtgcaaaggttgtatgacagtgatacaaaatcagacagtgcc
1355 3915245 — NO aattgggttcttgaggtggattggaggagaacagcctctggatgtctgctgggcagtgacgatgtgtctggaggctttgacattggattcattaggcattgcta
atgtacacaaaaaatgtagcaaaaatgatgcctgtttctgggtgagaacatctg
1356 3961553 — NO ctcccaggtttacaggtcttgactcagtacttcatcagcaataggttgtggtcacaggaaatggaagctgcctcaggacctgtagcaacttgcctgcatgctg
ggttatgttatcttttgagtggtgcccaatacgaggtgtctaggggaaagtcttaagtggttggagcccatgaca
1357 2523501 NBEAL1 YES tctcacagtggaattcgtccctttctt
1358 3601127 — NO gtgtgtttgtgcaagcatgttaagcatttctctgtcttgtgttcatt
1359 3892321 — NO tgcaggggtgtccagacggcctggtgcaggatccctttgatgtggagga
1360 3087823 — YES ggaggatgttcggactatagattcagctgtgggatctggttctgtagctgagagcacatcgctaaacatagatgtgcagtctgaggcttca
1361 3337295 — NO aaggctacaactgtgctcttagaggcaaaagaagaaaatgagactgccaggcatgaataatgagaaatctttgatggaattagccatgcagaacagata
1362 3528558 TRA @ NO tctttggtcccggaaccagattgtccgtgctgccct
1363 3536444 — NO cttttctctgtagttggcggaatcagctcagttacattttttactaagttacccacattctgacactccttgacagttttaagatcttcttctaacacacttgaatagaat
ggatactggaatctattttgacagctgttgaaaatctattctgttgttacaggaggttaaggaggttatttgtaacactgggattatttaatgaaccttttgaaaagg
tgtgcagactgttcaggcaaatagtattttttagaatttaaatgattttggttttcacagttaaattatcaaatgtaatgcttttaagaattatacacctagtaatatttttc
attaattttctccaccagtgtagtaatagtacattacaatgttctcaattaccggtgccttctaaaatgcaggtgtagagtctttaaatacagctagtctattgccag
ctgtcccatagataaccttctttaaaagtgacctttgagcaatttcataaagaataaatatttctagttttttgttgctgaactgctaaaagatggttctatacatgt
aacaggtggctttagttgggttgctt
1364 3823557 RAB8A YES atggcgaagacctacgattacctgttcaagctgctg
1365 2707806 — NO cagacccttgtggtcgagttgtttactttggtaattaagtacctgactctgctggacgctcttcgcgtttcagaagcgctgtttggcattgtacagtctgagcgtga
gttgaattcc
1366 2849541 — NO gttcttcataaatcctccactcacaagcttgcagcctttcctatcacagtcatatccaatctcaattcccctgcccagtataatgggactcga
1367 3795889 — NO acgctgaccagtgaccgaggacacagttgtgtgttaggctccatcacctgctgtactttgagttgggaaattttcatcatcttagaaactgggtcattttatcaga
gtctagagtcagatatagaaaaagtttgtggctatttctccaatttatatgactaaggtcgggtatctttttcaaagtgtctaattgaaattgaaaaggcagcaattt
aaagttgctattgcaagggcagaaaatggtcttaagaaagccagctttcaaattgaataaacatgactgcgttcactttttgagc
1368 3895772 — NO gaaacaaactgacaatactcgtgaaatcaacacccagatgaggtagaccagcactcca
1369 2920915 — NO ccaactcacaccatagcagcgctcatt
1370 2971825 MAN1A1 YES ctggaggcagcagtattctggcagaatttggaaccctgcatttggagtttatgcacttgagccacttatcaggaaaccc
1371 2990655 — NO ggtttcttgataactgctccacttagagaaatgagctgtgatctgtgtagattttggaaaatgggtagctggggggatcatctttaaacaatctttttcatgctcatca
cgaaatgcttttacaataggtttattttgactttgtgtttagaatttttttttttttttgctttttgctatagactctttaaaaaagttgttgttctggatattattgatagatgga
acaaaattcatgtccttgcttgaatcttttagcgagctattcagagattctatatccccatttactcatggttttttcaaggtgaatgaaacaacataccctgct
1372 3198975 MPDZ NO tgcactggtcctgacaatttttatgctgtgttcagccgggtcttcaaaactgtaggggggaaataacacttaagtttctttttctcatctagaaatgctttccttactg
acaacctaacatcatttttcttttcttcttgcattttgtgaacttaaagagaaggaatatttgtgtaggtgaatctcgatttttatttgtggagatatctaatgttttgtagtc
acatgggcaagaattattacatgctaagctggttagtataaagaaagataattctaaagctaaccaaagaaaatggcttcagtaaattaggatgaaaaatgaaa
atataaaataaagaagaaaatctcggggagtttaaaaaaaatgcctcaatttggcaatctacctcctctccccaccccaaactaaaaaaagaaaaaaaggtttt
ctaatgaaaatctttaaaaaatactgtcagtattttaaaattttcaacagtattataaaaacattgcatctccccacctctaatatgcatatatatttttcctgctaaaatt
ggtttctacaattgagtaaatggcaaatacatgaagcaatgtccctaaattttataaagaaattatatttaatgcacatttcaattttcattcttattttgaccttttgta
aaatattttcatgttgctataagtaaatgatgatgccaccccatgttgactatggtttttctagaaagcaactatgctgctaaccatagaggaacatagaagggtt
ccagaatctttagtgctggttttaacaaccgatgcaacattaaaaatgtgttagtgtgctgtgcaattggttttcaattcatattaatcttaatgacagagaacaatg
tgttactaattattttggttgtatgccattagtaaattgatagaaaaattaaggggattaacataacttcatttcattgacttatattaacatcttataatacaatagttta
agactaagggaaacagatggagctgtttattgagacaactggtga
1373 3652974 — NO ctgacatggtgtgtcacaaagagctcc
1374 3680296 LOC388210 NO gtagaccctacaccattcctcagcc
1375 2530462 COL4A3 YES ttccctgggttaatgggtgaagatggc
1376 2550272 — NO caggggcaagagctagttagaaaactgagctcgccctgtctctaatgtctggtgagctgctctcctctctctacaatatatcacgggtagtttcatgtcaacaaac
1377 3118585 — NO gaatatgttgttaagtgggcagcat
1378 3403090 C12orf57 YES taagtttgctcgcttggtcaagtcctacgaagcccaggatcctgagatcgccagcctgtcaggcaagctgaaggcgctgtttc
1379 2524930 — NO tgtgaacttgggttgtgtcgtagaaaatgtgagtgtcagagag
1380 3125787 CNOT7 YES ggttacgactttggctacttaatcaaaatcctaaccaactct
1381 3171102 — NO ccaaggactggcaggacgtcagtgatgctggg
1382 3250113 KIAA1279 YES cctgagcatataggggaagatgttcttcgccctgccatgttagctaagtttcgagttgcccgtctctatggcaaaatcattactgcagatcccaagaaagagct
ggaaaatttggcaacatcattggaacattacaaatttattgttgattactgtgaaaagcatcctgaggccg
1383 3747008 — NO ggtgactggaccacgcaggtagtttctcatgaatgatttagcactgtccccctactgctgtctcgtgatagagttctcatgagatttggttgcataaaaagtgtgt
agcacctcccctctcttttcctcttgctctagccctgtgaagatacctgctctggctttgccttttgccatgagtaaaagctccctgagacctccccagtcatac
ttcctgtacagcccatggaaccatgagccaattaaaccttttttctttataagttacccagtctcaggcatttctttatagcagtgtgagattgaaccgatacagac
aacaataacaaaaagtagataaatatgaaggccagagaaatggcaacttcttcacgaagggaagctgcttatcctcaagcaagtcagttgaggactatcctg
tgagctattttccgtgccttgttttccactcatacagggaagtatgccctggtgtctcacagttgcttcagttcttctttactgggaccctaaatataataacacact
gaaccactcaacttctcagaccttcaatatccctggggctttttctcaaatggacacagcatagctttcagaaagctgaataatgtagacaaaagaagtctccct
caccctttgattatggaaaaccaaagatttattcagtgccaaggataagaaaggaaggacttgatcaacaaccactgttaagattttgacccattcactacttca
cgtgaactcccagggaaatggaaaatgaaagaaggtctccgcggtagagggataacaatg
1384 2406715 — NO acagagccctgattccacatacatgagctcccatgtgtggctggggctctgctgggtcctgggggcaggaggaggatggagaggcaggccctaccatgg
aggaggttgtgatctaggggcaggctcctaaccagttaacatgtgcacagtttggcaagtctctcacagaagtctatagcatgtgggggaacccagtggaa
gaagtgatcgagctctaggatgaggaggagactggggagaacttcagagagcccttagaacttgaactgggactgggcac
1385 2808962 ISL1 NO cctccttggctgaaagagtcctttcaggaaggtggagctgcattggtttgatatgtttaaagttgactttaacaaggggttaattgaaatcctgggtctcttggcct
gtcctgtagctggtttattttttactttgccccctccccactttttttgagatccatcctttatcaagaagtctgaagcgactataaaggttttgaattcagatttaaaa
accaacttataaagcattgcaacaaggttacctctattttgccacaagcgtctcgggattgtgtttgacttgtgtctgtccaagaacttttccc
1386 2849483 — NO cctgttggtgtgtcgataatggcaaggtctgcagtgacccagcagtggctgaggtggggctggggctgagaacctgatccctgagaggccatttattgtaa
gaacaggcaacatggcagggaagtgaccaggaactaggacaggcagtaagtgggagagaatgacggcaagcctggagctgtcccagaggtgactga
cggatgctgtacaaggtggaa
1387 2868168 ERAP1 YES atttgccctacagatggtgtaaaagggatggatggctttgctctagaagtcaacattcatcttcatcct
1388 3082899 ARHGEF10 YES atggagttcgagtgaatttgaaagttacgaagagcagagtgactcggagtgcaagaatgggattcccaggtccttcctgcgcagcaaccacaaaa
1389 3505964 CENPJ YES gctgagaacgcatctttagctaaacttcgcattgaacgag
1390 3522535 DOCK9 YES caaagctaattgagccactcgactatgaaaatgtcatcgtccagaagaagactcagatcctgaacgactgtttacgggagatgctgctcttcccttacgatga
cttt
1391 3404455 — NO cactagacagcaattcagagcctccaaaataaagaatattcataaaagtaacaatagaggtaaatataaaacccagaattactacatgtgtcatatagtttataa
cttctcctatttatagctttctatatttatatttatctataacttcataggcaaatgaataaaaattataaatatgatagtggtcatataatgtataaagatgcaatctgtg
acagtcttatgaagcagggatgaagacatataggatcaaaatgtttgcatagttattgaagctatgttgatattatgaaattatattgttacaagtttaagatgctaa
ttataattctcaaggtaaccactaataaaattaccaaaattatgcagaaaaggaaaaaagaaaaacaatacactataaaaaaccaattaaatacaaaaaaagtc
agtaacagacaacttgagaaacaaagacatataagatatagagaaaacaaatgattaaatggcaaaagtaaatcttgttttagtaatcacattaaatagaaaag
gatgaagccatcctattaaagggctgagactgacaagttggctaaaaactaaaataaattaaaaagaaaaacaagactcatctacatgctgtctataagagac
ttgccttagatataaggacacaaagaagttgaaagtaaaaggactgaaaaagatattccatacaaacagtagtaaccaagatagtgccgagtggctatattttt
gtcaaacaaaataaactaaagtaaaatttacaagagaaaaagaagggcattatgcattgacaaaaattttgacatagccaaataattatgttataaaatatatgt
acttaataatacagcctcaaaatatatgaagcaataattgctataatttaagggagaaaagaacagttctatgaaaagttagagaatgaaatattccactttcaac
atgagattaaacaactagacataagatcaataaggaaatagaaaatttgaacaacactataaaccaattatcc
1392 3309338 — NO ttccagctcatcggcgttgaggtgcac
1393 2475878 — NO gctgctgagtctcaaaacagccaaa
1394 3032635 — NO gaggctcctcttcctatggatttgcttcaaggaggtcagggc
1395 3475556 VPS33A YES attacattgaggattgtatcgcccaaaagcactcgttgatcaaggtgttaagactagtttgcctccaatccgtgtgtaatagtgggctcaaac
1396 2930679 — NO gatcaacattcttaatgacataagagaagggagttgcaggtggatctaagggaaaactgttccagtagtaaaggagcagcaaatccgatagccctaaggga
1397 3489376 CDADC1 YES ggatcataaaacaggagttggggcag
1398 3933755 — NO gtttgcatttgaccatgtcgtgggcaggaga
1399 2430088 — NO tcattcttaaggctaaggtggcaagataa
1400 3420474 — NO atggaagcatgttggcgtcatcagcagagacagggaaattgggaaggagaggagagcataattagtgtgcagaaacttggaaatgctgacattggactcc
tggcaga
1401 3956302 PITPNB YES gactgtccccagatgtgtgcctataagctggtgaccatcaaattcaagtggtggggactgcaaagcaaagtagaa
1402 2334264 hCG_1820661 NO ctgctcgctgagatagacacatacctgattgcctcctttggagaggcttgtcagaaacaaaataatgcaaccatttgtctctcagctacctgcgacctggaagc
cccctccccacttcgagttgtccccgcctttctggacggaaccaacgtacttcttacatatatcgattgatgtctcatgtctccttaaaatgtatgaaaacaaactg
tgccctgaccaccttgggcacatgtcgccaggactccctgaggctgtgtcacgggcacgcatcttcaaccttggca
1403 2358760 SCNM1 NO cagcctggtgccctattaataagactgtcaaaaagaggtctttgcccttcatgttgtctgcctgcttctccactaccactcaaagtcctttcccccttcaaatcaca
taaggactgcaggtaggcactagggggacctggccacatctggaaacagggctgtggctaagttccctgtgaaagtagaagagtcaaaaggcattggca
gggttatggggaacaccaagggagggaacacccccacctcctcctagtaacctgaacctccctgcctgctgatccccagagtataaataatcccctggtga
actggcagtaacccttgggggttagcgccaagattctcaccccaaagcccaaggaaggaggcaggcaaaatggatagaagggcttttatttacaggaaag
gaggacagatgaggatttaagtgtccagtgctcccagcgctagttggtaaagggaaatgcagtgttatctcttcttttgctggcgacctgtaa
1404 4005886 CASK YES tcatcacaaagcacccagaccggtttgcgt
1405 2440191 — NO ctcctcacccgcatcataactcctcttcaag
1406 2561968 SUCLG1 NO aactgtggaatggatcacgtagacatgtaacccagcagcagtttgcttctgttgtccactgattaatcagcctatgtgcctgacactggtcttgca
1407 3216427 — NO atgttgagaaagcatatgcatgtgacagggcggatttgttagaagc
1408 3235909 — NO gttagactcggggttgatatctgtcatcgctgt
1409 3469137 — NO agcaacagaaagctcgtggtgttcctctgcctcaaaggccaaacgtctgtgggttttttgtcttggctgccgaccgcagcacgtcacactgtttgaaatttgca
gctgcgatcatttatcttcaggggacaggggt
1410 2343471 — NO gacagattgaaagaggtggtgaagc
1411 2464386 — NO ggtacacacattaggagactgcagttttggtgagaggtgatggaagctcgagactagtgaggaaaagggaggtgtcaacatgagccctagattcttggagt
ccagaacttgaaga
1412 2672266 ALS2CL NO gtgtgagcatgcacaggttagggtgggctg
1413 3730349 — NO tgggcctttcaaattgagtctaagtttaaaagatataaagaggtgtgggggaagggcattcctggcagagggaagagcatatgcaaaggtgtggaggccta
gaactacactgcagctttaaggggtggtgagtgatggccgggcaccgtggctcacacctataatcccagcactttgggaggccaaggcaggaggattgct
tgagctcagtagttcaagaccagcctgggcaacatagcgagaccctgtctctgcaaaatatttttaaaaaattagctgagtgtggtgatgcacgcctgtctact
aggga
1414 3755723 MED1 YES ggctcctccatagcagagaaatcttatcagaatagtcccagctcagacgatggtatccgaccacttccagaatacagc
1415 3861643 — NO ctggcaagcagacgggtttggaatagacattggaagaagcttttagggcatcctagacagcgttgcgatgcttggggcaggggcaggaaaaagccactg
atggactttcagggcagagctgtaatcgagttgatgtttcagatttagtcgaagggtgtgagagggctgagacggagaaagtggtgtggcagaagaggttg
ctggtggccatgggtcggggtgcagattatgagagaactc
1416 3542787 PCNX YES tttgatcctatgtgggagcgactgaaaatagaatgagcttggttaagcacctctcctttgcc
1417 2468417 RNF144A NO tgccaccaaaggcatggctgtgggc
1418 2520238 NAB1 NO gggaggaacatttaagctgatggaagtggaagtggaagttgctgtacattggcagcaaggcctccgagttagcttttgaatgcagttaactggtttctcttaac
tgtggaattcattgaaaagtcagactccgagtggtcgttccaggatatctt
1419 3129693 — NO cagcctgtgtgtactcatttccttctcttgagtaccactaatttgatagttcacgtatcctctactaagaggtagagtgagacagcttagggacatcagaagtact
actttcggttcttccacatggaaacatgaggaacgaggaataagtattctttccctaacacttacagtgcacttaagacaaagttttttttttttttggactgaatata
cgtcgatggacacaggcccagatatggagaaagggcaggtttcctctaggcaagatttgcacggggaacctga
1420 3845840 — NO cctggatccctgaagactgctctgagatcgatcagccagagagaaacagagagaaagctggctcagccctgaaggctttgagcaaaagtttcagaagga
gctggaaggagacaacagcccgttctccctgagctgtggccgggagggcccaggccagcaccacgatgtacagatggcccagggggctcgacatgag
tgagggctgaagttcgtgcaaccccaaccgccacccctgaattgggcagaaccaatttttttcttagcacctgtctgactctgcttaccatgacaaccccaag
ggccccccagaattgatatccaagtgcctttagcctatcaaagacaggagggggtgcattctcggccaggttagggttcacagagcatccgtatatta
1421 2621185 NBEAL2 YES ggctgtagacctggaccatgtgacagatgagcgggaacggaaggctctggagggcattatcagcaactttgggcagactccctgtcagct
1422 2871234 — NO tttgctgccatccatagtcttttcctaagtatcacaaaaggatatgcctgccaatctcttaaaaaatgacaatgcagacttgtgctcaaaatgaagctacagattta
gaacctcagattcaatgaactaaaaggagaatatattaaatgttaaatttgacctcagaaattccactatactaaggatgttgcctaagacctctcaaagactga
ggaccagcagaacactgcccatttcactctagaaccacacacaagtctgttgttcccaagccaatgtgaaagctataagccttgagactcaaaagagcaca
ggtgtccacaggtgacccaaacatcaaa
1423 2904825 C6orf127 YES ccaggggctcactttctccaacaaaa
1424 3133366 — NO gtgtcagtacagccgcgtggcagagctga
1425 2577848 — NO ggcttgcatcagcacacattgtacagccttgcaaattacacagaaattgaaaagaaggttccttgttcataagtgcaatgaatctttgatgtccagtgatccgct
gcaaacaatgaaaacaaactgtaaagcacttaagaagtttccagcactcatcaaatgcatttccttaggtgacaaaaaatccacaaggagaatgcaaataagt
ggcatttagttattagagagatacttgaaaaaaaaaaagtggaagtattttcctgcttagaatgatttctgttcccctttgaatgtaagtggtttaagaggcattaag
aacataatttattttatacttaatgttcacactacctaaatgaataaggaaagggccctacaaggaagagttatgtattttttggtaattgtttctgagtttagagattc
aggggaagagtaatcctctatttgtgggctcttcttagcatccctaacccccaaggagatagtacatggttttgacttggttatttcactcctgcattctttttcccc
caaattttaagttgggtcacattgtgctggctgcaaaa
1426 3332349 — NO ggggatgtctgcaatgtcagcactgattgcagcaccaaactcaaagacaataccactcatgccactgccaacatacccctggcttcctcaacaactttagaat
tattatattgccctaagtgcatctagaata
1427 2416733 — NO ggaaaagtacatgccagaagtcagctgtgcagtaacctatgagagagctactcctgtttcaccccagatcatcacctcgattccaaag
1428 2437457 ASH1L YES aagcaccagttgagattcccagtccttctgaaaccccagctaaaccttctgaacctgaaagtaccttgcagcctgtgctttctctcatcccaaggga
1429 2704212 — NO gagattgatgtggttgtcagctaaacctgctctttcagtagtggaaatt
1430 3888795 — NO gttgtttgccttgacagtgcggctgcgcttcggcctgctcgggttaccagggaacaaggc
1431 2556326 — NO ttgcctcagctgactttaccaaaaattccctttcccttccctgctttaagtcatttcatgtaggttagtcttcatttattcttttgcctctctacagtagttattgctttgtgc
tgtacatttgggttaaaggagttgtatatgtgtatggtgacagcataatgcctctgaagcccaggacctagctacttcttagctcctaacgtaatttcatccatg
1432 2878702 — NO gtcagagtgtataaggtgaaatgccgttctgtttttggag
1433 3328538 — NO gccatccggatgtcagctctgtggacattgactgctggttttcctggggcctcggttttcctctctggcctggcatggactgcctcttgccttggagttgctggg
atggtggggtgtgtgtgtgagtgagagtgtgttgttggggggcagtgccctggagaggacttcatagcct
1434 3496801 — NO aggactgtgtggcggactatgcagcatagt
1435 3668198 — NO tccacagggcagaaactattgcagagttcac
1436 3764547 4-Sep YES agcagtatttccgagacgagagtggcctgaaccgaaagaacatccaagacaacagggtgcactgctgcctgtacttca
1437 2544277 ITSN2 YES ggagtgctagcaagtctggagcatcaaataaa
1438 2581567 — NO agcagtttggcagccacatggattga
1439 2612556 — NO gcctgggggaatccgtgaacgccta
1440 2894809 SYCP2L YES ggtgtattcatttccgtgtattgctgcttt
1441 3956007 — NO gacagtcttcagaaaagggcagctgg
1442 2407214 GNL2 YES gaaacacacgtgtgattaagcagtcatcattacaaaaatttcaagaggaaatggatacagttatgaaggatccatacaaagttgtcatgaagcaaagcaagtt
accaatgtctcttctccatgatcgaatccggcctcat
1443 2948537 KIAA1949 NO tctttctcacatcctagagacggtctttaatacgcattaaccctgtgctgccacatctggctcctgccctcattgcctccaatccggactcttcctctcacatca
1444 3991159 — NO acaggtggactgcagggtcgtcttacaaaatgacaag
1445 2444356 — NO tagaccctgacattcagctccaataatggatgtcccagtatgccctgaatccaaacaaatgcctgactgcaataa
1446 2480997 MSH2 YES agacaggttggagttgggtatgtggattccatacag
1447 2671526 — NO atgttccttccaaatctcacattgaaatgtaatcttctatgttggaggtgggcctgttgggaggtgactggatcgtgggggtagatttctcatgaatggcttatcgt
catcctcttggttctgtccttgtgatagtgagttctcgtgagatcatgttgtttaaaagtgtgtggtatccctctgccttgctcttg
1448 2673140 — NO aagaccacattgagccacctatctccatctgtgcttatgtactctgcttccttcttgttaggatgaacaatgggcgaaccttccaagttcctatttaaagttacccc
aatctgtgcagaagatcctgtctcctcccacctactcaaggcattactctggca
1449 3394422 THY1 YES catgaaggtcctctacttatccgccttcactagcaaggacgagggcacctacacg
1450 2485881 — NO ggggtgacattcagattcaatcggtctacggatgagaaa
1451 2572007 — NO aggcttctttgacaatcgtttctgatctttagctgagtctagatggtaaaagtgaactagtgaaagggaagaatgagttttgttttggatggcatctcattattttttat
tttctttttatttatatatttgtttttcttatttttttttctttttgattttaatacctccaccctacttacagatattttttattttcttgacaactctgataaatg
atggattggaggatcagacttgttgacatcactgatgaggcttgtcttgttgcttgtcttctctggctaacattccttagtaaaaatatttct
atatttttttctttattttatttggtcattatttcattttgagcttttttcatttattactagataagcgagttttgagtgtcaaatttgcacttaatttgttttt
ggtactgtcataaggactgtagcatacacagcatactacaactgtaactttttacgaaaatatacattttttgaagatgacttcagaaa
ctgagggagagagacccacttgagactaggcagcaaacagtgaagaagaaatgagcaacatggtgtgcaggagca
aagtttcctactgtatatctctactctaagtgtacaatgccta
1452 2804366 — NO gatacttcatctagtaattcctgcccaggttttgaaacctcatgctggaccctcctgtgcaaggctgccctgctcattctgctctcatctgatcctctcactgggcc
agtc
1453 2369480 FAM20B NO tcggcaattgctcattctagggagggcatcatagttggtcagtcttaattcccatgccaaaggacaaacaggtgtgacatttggatagatgaatactgggattg
gctctggagcatgtgttttgagttgaaccttgcagtcctttctctacgcccgtggattttgtggaaaca
1454 2556336 — NO agtcctgtctagtggtcagtcctaacagtgtggttaaaggggagctaaatttcaactttcaggggtcagctgagacaaccacctagattttccaagttagttcca
atttcaagtacaataatcctttgacaacatagaaaagaattatagttagcaaaattgcaattgtcacagtcaaggtcttgttggtaatagagggttggggaaaaa
gttaaaacagcattaaatgaatatatttttaacataacaaaagttcccagaagacatccacttcaaattcaagccatattcatcaatgttaaaaaccttactcttctc
cctgatagtgtgaggaaaa
1455 2589618 TTN YES cctatccctgtaaagcctgtcccagaag
1456 3405368 — NO ctggggcataaaaaagcaagtgttctcactgagggatgaatagtctactagcaactgtaagacagttgcacgaataatgatgatacaaagaggtatccgatg
aatataatgtagcaggataaacaaaatggcagtggaaaacaggagtaaaaccaaagggaaggattctgagaagactatttataatgggaactaaaattgtca
gctgaagctcagatggcggtagaggcattccagatggagtatagaaaatgaatgaagaccaaggacaggacagaaatatctggggtgcactcactaggt
gagtgtgtccagacattgaaagaggatgagcagaggaagagaacaggagaggtaagaactaaaaaggtggtattaggtcctggaaggtcttaaatatcaa
gctaaagagttttactgccaagctacagaactttatcaaatgccatactgagaagactgatcgatttattaaagcaaactcctaaaggatctcttcttggaaaca
attcattagtggttagtgtggaatctcagtgtggcacggaataaagtaaagtacatgggtaacggccccagaaaaaccagagcacagcccagcgcattacc
actcatcgcctgggtgatcttg
1457 3447472 — NO ttttaaggagggttgcagaaagtga
1458 2331932 — NO tgccggtgcagttccttggtatactga
1459 2413973 USP24 YES tacgtcgatggagttcagcacaagcacgagaatttgggaatcttcacaatacagtggcgttacttgttttgc
1460 2972147 — NO aagtcaggagggttcagtgaccaga
1461 3568132 — NO ttaggtatttcgagtttgaagtgtctataagtcatctggagctgtccaggagatggttctatacatgaagatcaggaccagtttcttgtcatca
1462 3593984 — NO ccaggtggtctagcgctcctaacaaacaccttatgattatccttcattcaacagaggaggagactgcaggcatgcttcagtcagtggtaagaacaggaagaa
aaacccaaatcagcaacattttcttccttaatttggtataaacgtccttttcattatttcaagttactaatttgctaatctcaaatgttttctgaatcaggtttgctaaatg
ctgtaaagaatagctatccttcatacaatactaggttttattttttttagtatgtcagcataataaggtacatgcgcattcattccaccaacctgtttagataatactca
gcttgggtcatattcaaattctacacagagattctctgttttcaatacaactgcttagaaagcagaattgcctagtgatgactgta
1463 3878647 — NO gcagcccatcccgaagtgcttattacattagaacatttagtgcttttaaagatggtgtgtgtgtgtgtgtgtgtgtgtgtgcgtgcgtgtgtgtgtgtgtgagaga
gagagaaagcatatctaaatgttggtaccaaatcataccccattggaaagattcaattttctgaaattccacctaagaatttttgtatgtatatatgaaggcaattgt
gaaattatagagaattagcaaagtttatttagaatttgaggggtttggagtgcagttttacagattttctgactctcttttctttaatgtccatgcagagactaacata
attgacttttagatctttatccagagagtcaatccaattcaattcaaaaatgtttattgccagtccactctgaaca
1464 3271123 — NO gtgagtccctgggtcagtgagcaca
1465 3291284 TMEM26 NO gaaagtggcttatttgaggttgttggtgctgttggtattattgccatagttgttatttaattgcttgattaaactcagtcaaatatccttccta
1466 3859781 DMKN NO caaggagccaccagattggatgggagcccccacactccctccttaaaacaccaccctctcatcactaatctcagccttgcccttgaaataaaccttagctgcc
1467 2326309 — NO ccttcacggatttggttggggtcagagaga
1468 3091040 BNIP3L NO agtgcattgtgctctttccaagttcagcagcagttctatcagtggtgccactgaaactgggtatatttatgatttctttcagcgttaaaaagaaacatagtgttgcc
ctttttcttaaagcatcagtgaaattatggaaaattacttaaaacgtgaatacatcatcacagtagaatttattatgagagcatgtagtatgtatctgtagccctaac
acatgggatgaacgttttactgctac
1469 3823592 HSH2D NO ggggtgcttcatgtcatagcttctcagaaagcagcagtaactgaggctgtggatctgagaacgggagctgctagccaagcaatgagtgaagcttttgtccgt
agtggcatgttttatctgaggccagcctttgtactcctgtgtta
1470 3551323 CCNK YES ctacaccacaagtgccgcaagtacagcagtcacagccgtctcaaagctccgaaccatcccagccc
1471 3602745 RCN2 YES atggatttgttagtttggaagaatt
1472 2332284 — NO cccggcgcgtatcgtaggcagtgtaccgtggccgtgccgtcagagtgtgcgtgtgcgtgtgtgccgtgtcgaggctgtgtag
1473 2689891 — NO ctagaactatattagctgctcagtgagttgggcaattggatatttttggttttatgatttcagattttatagaccagtggaatacaggccttgtgcatatgaagatca
ggtgacaagtttgc
1474 2952713 — NO tgtttgttgtttggttatgatcttgctt
1475 3181289 TMOD1 NO cggtggagtccatgcctttgaactggatgtgttctattgatgacctgtgctctgcaggggaaaccagaaggcaaaatgctggcagcatgaaacccttttgtgg
ttcagttctttatgcactaaggttttaggttgactagtggttgtagttgaaaattttataaaataccgttaatgtgaagtttttctttagtcacagaagttgaatctggtt
attatttaaaaactagaagcccccaaaccagcagatcttactgaagatgatgttccagcagcagcgacttagccccaggagcccagtttcaatggccttgctg
tgtggtgtttcaagtgcatttaaaatgtgtgacacagaaacggcacactcttc
1476 3412443 — NO acctttgacatctctagcacacggagcaattctagatggttgataaaagagcataaatcaatcgacacaaatatccccttaaaccttgtctttcatgtccagtatt
1477 3886313 TOX2 YES atgagtgacggaaacccagagctcctgtcaaccagccag
1478 3976557 RBM3 NO atgggacgtttgtagaacctgagtatttttctttttaccagttttttagtttgagctcttaggtttattggagctagcaataattggttctggcaagtttggccagactg
acttcaaaaaattaatgtgtatccagggacattttaaaaacctgtacacagtgtttattgtggttaggaagcaatttcccaatgtacctataagaaatgtgcatcaa
gccagcctgaccaacatggtgaaaccccatctgtactaaacataaaaaaattagcctggcatggtggtgtacgcctgtaatcccagtgacttgggaggctga
ggcaggagaatcgcttgaacccgggaggcggaggttgcagtgagctaagatcgcgccactgtactccagcctgggcaacagcgagactccatctcaaa
aaaaaaggaaatgtgtatcaagaacatgattatccagcggtattttctaattcagatcatcaaactgattatatagaagagttggctttaaaatgtttgcaaatgtc
tttttttttttaatactggaagaaaaaatattctgttgtgtctcatacagtgcttaggatgtctttc
1479 2635686 PVRL3 NO ttccatagctgtagctggagcggtaattggagctgttcttgcccttttcatcattgctatctttgtgactgtgctgctgactcctcgaaaaaaaagaccatcctatct
tgacaaagt
1480 2680971 — NO agttggcttacaacctgtgctgtattga
1481 2715956 HTT YES ttgagttgtacagccgctggatcctgccgtccagctcagccaggaggaccccggccatcctgatcagtgaggtgg
1482 2452913 — NO ctgtgcacaggactcctcaaatattttccgtt
1483 2667796 — NO caagagaaggtgagcatataacaggtaaataacagaagctctgattttttttttctttttatagtttgggactattcatccagcaagagaaggacgcttaaaagta
gatt
1484 3602153 C15orf39 NO aagggattctgatgagccgatgggccctggaggcagcccattaaagcatctgg
1485 3752031 CRLF3 YES taccaaaaaggcctcgcacattcagttggacag
1486 3765307 APPBP2 YES ggaaactgaacagaggctgcttcaagaagctcatgatttgcacctgtcttcactccaactagctaaaaaagcttttggggaatttaatgtacagactgcaaaac
actatggaaaccttggaagactt
1487 3956644 — NO gtacatgcaaacgggatgggagcag
1488 2345202 — NO tgatgcccgcgttgtcttttcagactctgttttttgcctttagcatgccttgtaatttttttttttttttttgataagctggatgtgacataaggggtaaaaagaactgaga
taaacaggcctttagtgtggcctagaggcctatctggctaggagttaggctgtgtttactgtttgatgtagctttggtgtcagagattaaaatttcctctcgtgtaa
ctgcttttgtctcctttgttgtctttgggtttccctaataactccttcataagtaggttccgaggcttgtagttatttaagctgtaagtccctgttattacacaggagcc
ctattgatgtggtgtgtgtgtgtgtaaaagtgttctataatcttatgattagctcttagtgagcctgtgtctttggactgtgaccttcatgagtgctttttagc
1489 2655521 ABCF3 YES aaaggagagtcggttggaatcatctggcaagaacaa
1490 2920283 — NO gcaggacatacgctaaaaccggagcaatacagagaagattagcatggccctcacccaaagatgacacgc
1491 3102056 — NO agattacaaactcacatttaatgttataaatgcagaaaaaggccaaaaacacaaaaagagtggcaacgagggacag
1492 3161310 — NO tgaagaccttcacgctttctctgtaagttttcattcaaaacatctttcaatttcttttttttctttttcttcttttttgccctcattttagttagtttgagtttcttgtggctctgta
gtgactgctctaatagaatatcccttacaactttgtggcagttaatttctggatgatcactgtgacttccatttacatgtatttgg
1493 3289083 — NO acaggtaaattaggacggcactgcgggtactctgtgttccgcctgctcaagttctagacttctggtgtccatagcaacccagcaga
1494 3304760 — NO cggggaggaaagacagctctaccag
1495 3895434 C20orf194 YES tctttcctgggcacttatctaacag
1496 3406522 — NO tggttttgtggataggggaaatctagtagatattaaatatttttatctgcaaaaagcatttggtaaggttctcaatgggagattaatgactaaaataaagaatgagg
cattaggagataaatttgcttatgagcaagagacagatactaacagtagaaggaaatactttttagattggaaaggagtgacatatagcacaagccaggaatc
agttttgggaccta
1497 2692051 — NO gtatcggattaagctcaaaacgggaggaggaaacaaggatgactggagtcaaggaa
1498 2835105 LOC728264 NO ggcaggggttgggacaagtgctaagtatgcaagactcaagggaagagct
1499 3935012 — NO cttctccaggccagatttaaccacataaacacatcaaatcccagct
1500 4038282 — NO tggctgggtgagttctaaaaatgcccaagacctccaagactaggtgagatctgaagtaatgaaatgcctccattcactaaaggcctgaaattgtcctgactgc
ctcag
1501 2856770 — NO atgttcaaccagatgatgggccatgattgt
1502 3579731 — NO cccatgtgtatgctttgagccgttccttagttgagtaggtgattgaccataccagcagcactggtgccaattaagcggtctgcttggttcacacagcctttcattc
ctgttctagcatggctctgtcttaaatctgcatgcatgtatttattccttaatatattacctctcttcctttcttcctttttacatttcttcccattttttattgtttctctctctct
cactctctcactcattctctcttgcactttgtcttcggagctcattgccatggagtggcttggctgtacgcatcaaaaagccacccgcaaacgtccatccttggc
cgtgcggttccacgtctcactcattacttccttcctgcattcatagcatccttccttcctgcttgctctctttttattaggcatttattcctctattagtggagtcaggtg
cccttatgacaagtcctagc
1503 3636549 — NO ctactgaaagcatgtcctgtgaatgttacttgtcagtgacaaaataggtacagaaattgaaataagagtttagaaatttttagagccgtttgatggagtagctttgt
gaatctaataattgaggcttacattttgtatgtctttatttttctcataatttatttttattttataaacatgtctgtttgcaactcattagaactttaaaaaaaaaaactagt
cattcactctaggtagagtagaagtactgactatgaaggatctttaaaggtcaatagtggtcctaatacgtaaaataatttgctcatatggtgtatttaaactattg
gcaactatgtaaaagggggaatgggttgaccttcatgttacaaatattaatttctcctgcataaaagtaccctcattg
1504 3653150 — NO tttcatgagatctacacctgggctgggcacgcctgttggttttttactgacaacgcataatttttcgaggagtggtaatcagaggcaaccgttctagtgacagtg
attcaggcgtaaacacttggctttggcccagaggttgcactgtgtgagaccacaggtgaacactagaatgtttacactcttccggagtctgtaggtggatgcca
1505 4011856 IL2RG NO cagggtcctgtagccctaagtggtactaactttccttcattcaacccacctgcgtctcatactcacctcaccccactgtggctgatttggaattttgtgcccccat
gtaagcaccccttcatttggcattccccacttgagaattacccttttgccccgaacatgtttttcttctccctcagtctggcccttccttttcgcaggattcttcctcc
ctccctctttccctcccttcctctttccatctaccctccgattgttcctgaaccgatgagaaataaagtt
1506 2351151 — NO aaatagctgggtctcagtgtctcttt
1507 2577491 — NO gttctccctagttttctctacaacagtggaaaacaaagcagtgctctctatgccaggacagtacatttggacggcgacaccttgtttgcagaatcct
1508 2693258 — NO atctacattttcacactgacaccca
1509 3156385 — NO agtcacacccttggggatctcattgtgtttcatgacttaattatgctgctgactctcagattgttatcttagtttttcagacttctttcttgaactccagacccgtggcc
actatgttctcgccatgtggaatctgatgtctcataagcatttcagacttaatatactcaaaaggaactgatattcacgccaagcctgcttctctccccttctccact
cactaaatggcactactttccttctggctgg
1510 3175668 VPS13A YES cttggaggtattatagcagaagtgaatttggccgagcattctacagttattacatttttagattatcatgatggagcagctacattcctcttaataaatcacacaaa
gaatgaacttgttc
1511 2389740 — NO atgagtgattcattctgccctgtggacacttgggaacagaaggcgactcttgagctgggttttccaggcttattaggcgctcagtgggttaacagaatgagctg
gtccaggaagagatcagcctgtgaaagccgtggctgggatattattggagat
1512 3224499 — NO atctcttaggtcatatgtcatcgcattacctttaaaaattgtatggtctaaatgtaaaatagttatttttcaacatttgttttaatacccttgtaactgctttttactcaaga
cagacatttcacttacactaagtgtgtgtgtgtgtgtgtgtgtgtgtagaaacttaggatataacacgtatgtaaattacacacacatacctgtttaaatgtaagaa
ttcagtgataggaacagttcatctaagaagattttaatgacagggcactcttttggccaaagcagtggaatttcctaagcagcaaggttggtaatagtgctggta
ggatctgtatgtgtaagctgttacacaagctgaggatcaaagtgccaatttctcaaggagaaaaacttctccgagaaatgaaagtctctgatctgtgttgtatgc
cctaa
1513 2807754 C7 NO gggccagaacacactctacaaaatgactaggataacagaaagaacgtgatctcctgattagagagggtggttttcctcaatggaaccaaatataaagagga
cttgaacaaaaatgacagatacaaactatttctatcctgagtagtaatctcacacttcatcctatagagtcaaccaccacagataggaattccttattctttttttaat
ttttttaagacagagtctcactttgttgcccaggctggagcgcagtggggtgatctcatctccctgcaacctccgcctcctgggttcaagcgattcttgtgcctc
agcttcccaagcagctgggattacaggtgcccgccaccacgcccagctaatttttgcatttttagtagagatggggtttcaccatgttggccacgctcgtctcc
aactcctgacctcaggtaatccgcctgccttggcctcccaaagtgctgggattacagacatgaaccaccacgcctggctggaatacttactcttgtcgggag
attgaaccactaaaatgttagagcagaattcattatgctgtggtcacaggggtgtcttgtctgagaacaaatacaattcagtcttctctttggggttttagtatgtgt
caaacataggactggaagtttgcccctgttcttttttcttttgaaagaacatcagttcatgcctgaggcatgagtgactgtgcatttgagaatagttttccctattct
gtggatacagtcccagagttttcagggagtacacaggtagattagtttgaagcattgaccttttatttattccttatttctctttcatcaaaacaaaacagcagctgt
gggaggagaaatgagagggcttaaatgaaatttaaaataagctatattatacaaatactatctctgtattgttctgaccctggtaa
1514 3929304 C21orf59 NO tccacacagtgagagtccagggctcagggctgctcaagaccaaggcttcccttgatgcttcacttcgggtgatcagacatgggggacctgtttatctttagta
gccggcaaaggcaatcgtaaaacatttgttgtaacttcaggattgtcactctaagaacacc
1515 3947636 TSPO YES gtacggctcctacctggtctggaaa
1516 2748234 — NO cgaggtttatgttgtgttaggctcatgagaaggcaagaaattttattatttaaatgttttctccagtaatgtattggattcaagccattgagatttggggagtgtttca
gtgacttatttgggcaaaacagaatatttgaaattggcattgtctcagaatctggc
1517 3630746 ITGA11 NO gactgtaaatacgaacccaatctgcacactccaggcctctagttccagaaggatccaagacaaaacagatctgaattctgcccttttctctcacccatcccacc
cctccattggctcccaagtcacacccactcccttccccatagataggcccctggggctcccgaagaatgaacccaagagcaagggcttgatggtgacagct
gcaagccagggatgaagaaagactctgagatgtggagactgatggccaggcaagtgggaccaggatactggacgctgtcctgagatgagaggtagccg
ggctctgcacccacgtgcattcacattgaccgcaactc
1518 3004500 — NO ctcatgcttcaaaggcatattctcaagaaacaggtgtaatttgtgcagataatcacacctgggaagggatcacagagaaggagaaaaagaaagaaatggct
tattctgaggtgaatgtgtc
1519 3552925 DYNC1H1 YES tgccaccttgatgacgcagtgcaaagagggggcacagaaggaaggcctgatgctggactcgcacgaggagctctacaagtggttcactagccaggttat
ccgcaacctccacgtcgtgttcaccatgaacccgtcctcggagggactcaaggaccgggcagctacatcacc
1520 3649810 — NO cagcaagaggtgcaggttgagtatttggaggtggtatatttggccagactttagccgcatcgattatgctatttcttgctggctgttttaaattttttttaaaaagga
ggaggtgtcagatacatcatttca
1521 2782685 — NO aaaactagggctgtccaggcttaca
1522 3166121 — NO caaaagcctgctgctgggtagatag
1523 2524769 — NO agtgtagtgcagcattgcctctggaactggcctgattcttgcctcataaaattcttgtgaccaataaatgaaattctacacatttttatgtgtctaaaatcccaagac
tagtatctgacacatggttagctctcaatatattttagctactgctattatcattattggtagtactattaaacattttgaaacagaaaatcacttggggctggtcacg
gtggcacacgcctgtaatcctagcatgtggagaggccgaggcaggtggatcactggagctcaggagttcaagaccagcctgaccaaatggtaaaatcctg
tctctaccaaaaaaatacaaaacttagatgggcgtgatggcatgcccctgtagtcccagctactcaacagggtggggtaaa
1524 3101675 ADHFE1 NO ttaactgaaagaattaccgctggccattgtagtgctgagagcaagagctgatctagctagggctttgtcttttcatctttgcgcataacttacctgttaccagtata
ggtgggatatacatttatcttgcaggaaattccccaaagctcagagtccagttccttccataaaacaggctggacaaatgaccactatgttagacccccaggc
tcgacttcaggggtcagtgttcctgtcccaaaccccacacagaatactctgcctctgtttcatgtagcaaatga
1525 3633418 SIN3A YES cacctctcacttgcgtatgaagacaaacaaatactggaagatgctgctgctctgattatccaccatgtgaagaggcagacaggcattcagaaggaggacaa
atataagataaaacaaatcatgcatcattttattccagatttgctctttgcccaaagaggtgatctctcagatgtggaggaagaggaagaagaagagatggatg
tagatgaagccacaggggcagttaagaagcacaatggtgttgggggcagtccccctaagtccaagttactgtttagtaacacagcagctcaaaaattaaga
ggaatggatgaagtatacaacctcttctatgtcaacaacaactggtatatttttatgcgactgcaccagattctctgcctgaggctgctacggatttgttcccaag
ccgaacggcaaattgaagaagaaaaccgagagagagaatgggaacgggaagtgctgggcataaagcgagacaagagtgacagccctgccattcagct
acgtctcaaaga
1526 3904327 — NO ttccaaaggtcgctaaagatactgttactactattgagatattattggctacttcacgtttacatagtaaatgtttgcagcatataacattacagactcataaaccca
taattaacttataagtgttaatggacaactgtgctttgatttttgcctttagtgataagaaaacaaagtagtgaaatgggtcactcctcaaagcatggaacattttaa
ctttgcctagtaaggaaaaacaaaacaaaatatagcaattacatgtggaaccgtaacctgcaaaagtaacacaaatattgtctcaaaaggtacaaataggttgt
acctggaccttaagcagcatg
1527 2652509 FNDC3B YES gcaccaattgacaacggttcaaaaatcaccaactaccttttagagtgg
1528 2441680 — NO aggcaagagccctttcgtgcaagtaagcaattttgctgcctcccattttttttttttttttcaatctgtttgggactttgagggctggggtgggaaggtagtggaatg
gaatagataaacagccagtcaagagctgtggggaggttgacagaattggggtgcaggtacatgtaggatacacagaagctttgtgtctgtggaggctgtat
gagtctgtgggtgagcagcatgtctaagtgggtggaaa
1529 2694895 — NO atgccttggagacgagcccagaaggag
1530 3048170 C7orf44 NO tcctatcatagctggcaccgtgttcatgcctgtggtattccctgtatccctattcctgggaagcagcccaggagggggattcccttggcctctccagggtcagg
tcacctttcccttcattagtgtgatgggaccttcagaagagaagcactttctgcggccaaactg
1531 3085948 — YES gaggccggtagtgctgaatggacatggggctggatgaaaagacttccgcctgcctctctcagccccggaatcgccatgagctgctatt
1532 3300246 CPEB3 NO ggcctttccttggtgtgacacttgaactagtcgattttttgaaggctataacctaacctcgactatttgttgttatgtgca
1533 3822344 MGC3207 NO ttggagacaccatgttagtcgtggctggtctccaactcctgacctcgggtgatccgcgccccgcggcct
1534 2345520 — NO aagcctgtttgagagcaggactgat
1535 2549493 — NO gctccggccgagagaagccaccattcctttc
1536 2788417 ZNF827 YES gaagagttactggaagcggcacatggtgattcacacaggtttaaaaagtcatcagtgtccgctctgtccattccggtgtgctcgcaaggacaatctc
1537 2544515 ADCY3 YES actatgtgaccttcatggtgggggag
1538 3329911 NDUFS3 YES ccactgtcagaccacggaatgatgtggcccacaagcagctctcagcttttggagagtatgtggctgaaatcttgcccaa
1539 3467685 — NO cagggagctgcatgtccaactgttctcaggggagaaagtttggccttctctaggaacagacggagagaaggcaagggatcctaagggagatggtgcaag
ggcttttggggagtttggggtttatccaaaatgtagtagagaagagggttcttgaagagttttcagcagggatgggacatgtgggatttgtgtaaagcaggga
gcaaactatggctcaagggcctgctttggctcactgcctgtttttggaaacaaagttttattggatcacagacacaccattagttttcttaggagctacaaaggc
1540 2535364 — NO atcaaggaagtcgagtaaaacacttct
1541 2979944 SYNE1 YES gcagcaaataggtgaaagattgaatgaatgggcagtcttcagtgaaaagaacaaggaactctgtgagtggttgactcaaa
1542 3210881 — NO atggctctacagcaccggattttgcatcagaatccttcgagtttcttatcttcaccatctgtagcatttagattgaaaaggcttacctgggttttctttttttgtgtttt
atgatctcaagctattgggagtagaccaattcgtgtggctcaatatgagagttaaagttacgtcagaaggtaatgaaagctgattttgcccttttattaactatagt
attttaatcctggtatgtaaaattattactcatttgtgcctaatgcagataatgggaagcagctcactgtggtaaagtaggggcattaagcacaggtgcaac
1543 3984493 — NO ccagggaaatatgggaactgtgagaggcagcaggcaagttatgggcagaggcagatacaatgagttcatgtgggaaattt
1544 3294206 — NO ttttttctgcactcccattgcttta
1545 2389550 — NO atgtattggtggacagcatctaggaagaga
1546 2593736 — NO gctgtaacactttactatgtctatgcaaatacacatttaaacaatataggaagatttcaataaccaaactaactgtacaaaaaataaacaaattaactttattacatt
gctacttcaacttcagtccttacattgatttgttttttaaaaaataccagtttgaaacacattactgaaagtgagtgtacacaataaatagaaaatagggatgcata
gtgctggagacattcaaccaacttatcttcatctgttgcctactgttg
1547 3315642 ATHL1 YES gaatgcagacgggtcaggcgctgtgaacttcct
1548 2638195 — NO gtcaacgaggggaatccactctgcc
1549 3973655 — NO cagtttggcaaagagcatgccactgttcctgctgtctatcaaag
1550 2409486 — NO tctgaaatccgacatcccagtgtccattctggggcacagcttcccctcctttcaagtctctctcttcctccctctccacaacacagaggcctttagctccccagc
ccttactgttcagtgcgtccacccctccttgtctagaccctgaagtatattacatcagctactctcttgtgagctcctccagtactctgccccttgtccttctattgcc
ctagtctagg
1551 2635963 PHLDB2 YES cctgcctgtccggaaggaagactttgatttgcggagccatgtagagactgctggccacaatattgacacctgttaccatgtatcaatcacagagaagacctgc
cgaggattcctcatcaaaatgggtgggaaaattaaaacgtggaaaaaacgttggtttgtttttgatcggaacaagcgaacattctc
1552 3730508 TANC2 YES tccacaatgttgctgccttgctctgccgctcacctcagctgacagcctatcgggagcagcttctcgggaacctcacctgcagagcatgctgagccttcgttc
ctgtgttca
1553 2512118 — NO ggcatatgtttggtatctctggtccttagttcctgaacaattctgggctaatgctgtagtca
1554 3181032 — NO tgcttctaacaaatccgccctgtcacatgcatatgctttctcaacattcactgtcaaaaatgccctaccaggacacaacatagtgacaataacacattcaatttaa
ggataatggttgagagggaaccagctaagaacttacaata
1555 2401404 ASAP3 NO aggcctctggatggcagaaggaaag
1556 2496802 MAP4K4 YES tgatctttggtcttgtggcattacagccattgagatggca
1557 3048180 — NO tcagatttactttcccggagtagtcacaggactgggcagtga
1558 3436406 — NO ctctgtgccttatcaggagagggtgactctgtgccgactttacaaggctatgggaaggacac
1559 3840203 LOC400713 YES gctgtcgtagagtggcaatcatcagtggc
1560 2633650 NIT2 YES ctggctgaaatacgccagcaaatccccgtttttagacagaagcgatcagacctctatg
1561 2835873 — NO tgatcaaatagtgccgtctgcctggagtacagcatgggggaagaggtttggctgtgttttgatgtagtcactgcccatagtgttgtagttgcttcattttgatgtgt
catacagctaaagatgctccctttaggtcatttttgttgccgctgcctctgcggcttgttactactgtt
1562 2849540 — NO agaagacaagaggaagccgttctgctggcatttcgtcgggatgaagacaacacagcca
1563 2986834 — NO ctggccgtgtttcctgtgagttttgagg
1564 3222790 — NO tgctgttctgcttctcccattcttgcatagagtaatggagttagtgaaaatgggctttcttttacaacacaaagtgttgctcttctttctcctagggagaaagtagta
agctctgtgggtgtaggaggaggaaaatagcaggagcttagccaaggagggtgctgcagcacatgtgggtcttcatagtccggaagggtgagtgacac
1565 3317133 — NO ccaaaaggactgtcgtggcagagcagccatggccaagtggactcagggttcattttcggaacccctttaagcttatagaaagtccccatcatcacccagctc
ggccccggggcaccgagtccgtctggtgtggggcgtcctttcgacagagcctcctccacaaacccagactctggcttccaccagggccccggacacctg
cttcctcagggcagacagagaggggtgacacactgcaccctgtggctgggaaaaggggcctgggactgtgcccgtctgggacggagcagagccacca
tcccatgcaggcactatcaccgcaggcaaa
1566 3600340 — NO agggccactcaaccatgcgctctgggaggagtgggctgagatggggctgcttggtcagccctgactgtgttttgatctttgggcgtcacc
1567 3929187 — NO ctggccaccagggaacagttacgtaaattatttgatgtgtctttttaacaagatattaggaagtgctcggcattgttaggattttttttggccacgtggaaaaacac
acatgatataaagcaaaggaaaataaggcagtctgcaaatggatctgcttagaactgccattacgtaa
1568 3989061 — NO cttgctctgtcataccttgtggaaatgtaaaagatcaatgacagctagcctttcacacaattatttatgcctcggccctctaattgacacagttacccctagcact
catcgttgtgatcacctgcagccaagacgctgattttctgctcctatagcctggcaaccttgtggtacatgggactacgtccttta
1569 2735839 MGC48628 NO tatacatatgtctgcctctaataaa
1570 3660480 — NO tgagaccgcaattccagcacgcattggcaggacct
1571 2655657 — NO tgggaggaggacgtctttgggattccttctcttcatgagctgc
1572 2848543 — NO agcataaagaaagttggcctgggttttcgtgactcggcagggtccactcagtttaaaatgc
1573 3397172 — NO ctgccgtgggcccattgaccagagcgacctgctgtctgatgcc
1574 3790842 — NO atgtggcgaatgggtagaagaatgt
1575 2824108 — NO ttttctgattcactaccactgctggtgttacagcgtgaacgtgacctgaagacaa
1576 3361136 — NO agaagcaggtataagccaaatgttgagagttagagaatgccagcctgcagttgtcatcacccaggcttagtacc
1577 3971846 — NO atgttcactcaggctccttggtgtg
1578 3294447 ANXA7 YES gtgagttttccggatatgtagaaagtgg
1579 3850170 S1PR2 NO gttgcactatttggggcacagaataatcaccaaaagtgagaaaaacgagtttgggtggctggggaggactttgggactcttgatgcaaggcgcaacttgag
aaaattctgggtgtgatatttgcacagacaccctcctttcaaaaacagccaccccccaagctattctcagctccacacctgcagccccagctaaggtaccag
gtctcctgagcaaggcagagagaagccttgagccttctctgtgtcttctttcaagaaccccgctgtgtcttctttcaagattttttttttgagacagtttcaagattttt
gttttgtttttgagatggagtctcactgtgtcacccaggctgaggtggcagtggttcaatctccgttcactgccacctccacctcccgggttcaagcgattctcct
gcttcagcctctcgagtagctgggactacaggcacctgccaccatgtctggctaatttttgtatttttagtagagacagggtttcactacgttggccaggctggt
ctcaaactcctgacctcaagtgatccgcccgcctcggcctccccaattgctgggattacaggcgtgagccactgtgcccggccttcttctttcaagttatatag
aatggagcatgggggtggcagtggctagggacatttcctggggacactctcccctaaccccccagaaggacttcacaaaaacctgtggataatggaaggg
atgttacggtacaaacgtatatttatgtgtgtgtgtgtgtatgtgtgtgcgcgcgcgcgtgtgcacataggcgtgatgtctgtgaccctc
1580 3918219 — NO tgcggattcgtctgctccacgcagggtgctctgacgtactctgtgtggcctggagctcagaaacctgtgctggactcagtg
1581 2370552 — NO gttggggtgaactgaacctgtccattt
1582 3476124 — NO gagcgggatcgaggcgtttttaataattcgagttgggaagacccggatggttcatcaaaatgatggtgttgagcacccgggaggcagacattgggtatttgtt
cacaattttgcacctgtaagaaaatgttcctttataactttcaaggattgccgtgagcgtctttggggccttttcattcatgtacaagtttcattcattactattcaactt
ggtagacttggtgaaaaatgtaaaagcattctgtatttggatcagtcttgggaactaaatttgtcgtgaattggggcctgtcacagattgcctccagtgtgcatcc
tccacgcagaccctccttgctcagtctccctctggcgcccatggggaagccgtgctgtggttggcagtgcggccatctgggctgccgcaacgtggcaggg
caccgtccagcaagactgccccttagtgcagggctaagcaaggaaaagaagaagcccaaaaaggcgggttctttttgatacttgtaattcaggcgtcctcc
agagtg
1583 3929424 C21orf66 NO ctgttgctgattttggtgacacatctctgttgatatcagtaaatatcaattgataagtaaaaaaatatgcaagtcttaacttggatgtatttcatcttgcatgtgctcac
ctccctcccctctcacccagtcgtttgggttgtttgcctccccttactgtcatatcttcatagtgtggaactaaaacgtagaaatgagggaagtatagtggacag
atgtttcccccaccccttcttttacctaggcaagagattaggggagtcttttttgattaaagagagtaggtccaaaataaagaccctgaaacactaaaatctggg
gatccccaacaaaagaactggctcagtacctagtgatccgacggagacacctctgttagacagctcctgcccacacacacagcttccagtcttgctatctat
atgaacaggcagttaacgatgatcataaggaccaacctgagcagcagaaccaaagggactgaggaaacagacagtgctggtacaagtatgcaagttttct
gtaaacagattactttcaaacagttgggagccccagggagataatagaaggtatcctactcaacaggagtatatagaatgctgtagaagaggaatattgtaa
gaacaagaactatctcttgaaaactaaaaatatgataactgaaatataaatttaaataggattggaagctaaagctaggaaattaccctagaatgttttagagaa
atggaaaatacgaagaccaaaaaaataaaataaaactatgctgtgaaagagaaagattagcatttgagaaggcggaagttggtcctgctcagatgcggtttt
cagatgcc
1584 2418445 — NO aggtttcaacccaactggacctgcttg
1585 2977983 EPM2A YES aattctaccaaatatctggctgggtag
1586 3074397 CNOT4 YES ttcatccaatcacagtgcacggtccccttttgaaggggcagtaacagagtcacagtcgttattctcagacaattttcgccatcccaaccctatcccaagtgggc
ttcctcctttccccagctccccacagacatccagtgactggcctacagcaccagaa
1587 3320669 USP47 NO cggtggagcctcatgatctcttatcttttgaggctgaggcaggtcacatgcaacaaattgtgaccctgctccccacaagtcatgcaaaggttttgaagagctttt
accgtggggcagatgaacttgtgtcaaccatgcacaccctgtgagaaccaagtacctgtgtttctaaggcgggcactcaaggtgaggggtgcattctggcc
aaagaaacaaaagctgtggtttcaggaccatgccgtgtgtagctgatctgtacgggacgtgtatgtaaggaagagcaatcatgatagataagaacagtgtgt
gaagcagccttcacactagagtgtttggtcatctcttataatgtaagggaaggtactttaaaattctgggaagatgcgatgaactcatgtcccagtcagaaaata
atccaatgaaataagcattggttgccaggccacagttaggaattgta
1588 3562057 — NO gagcaaaaatattgtcaggtttcttgctgtggttctggatgttcagtagcaggctcatttg
1589 3924690 DIP2A YES gggcctcgtggagcattcgtactttgagcgtccacaggtggcttctgtgaga
1590 3029146 — NO agtcaactcggggagtcaaattaggaaaggcttcgaaggatgggcaggacgtaagaatccagagaggagagggatgtttggagaacagaaagtggaag
gttcctgtaggaaaatgatagagctatacttggagaggcaagcggggc
1591 2480430 — NO tcttcactgaaggtgccagcctatgggtggactcgtgatctagacctaaagggttagtgtgagttcctagaggaaaagaaagccatgaggcagattgtggaa
ggctttgaaggccaggtggagggccttgaactttattccatagacaatggggagctattga
1592 2923442 — NO ctgggaagaacttcaggctgttgttcagggcatggatatcaccactgtcca
1593 3393487 FXYD6 YES cctctggaacctgaggcggctgcttgaacctttggatgcaaatgtcgatgcttaa
1594 3879288 — NO gctttcaagaatacggccatgtctgcattgttggcttacacgcagacacacgctcgggtttttcatttggcagggtg
1595 2889490 AGXT2L2 NO catctcatccaaatacacgctattgagaaggcgagcctgacctccctcttacagataaagtcagctttcagaggctcagggtgggggggcctgcccgaggc
cataatgctacccaccccctcctcctaaccactggtctgttggaataaccca
1596 2915334 DOPEY1 YES agattggttgagagtctccgtttgccacaggtgccaactctccattctcaagtgttcctgtttttcagagtgttacttttaagaatgtctccccaacatcttacctcac
tctggcctaccatgattacagaactt
1597 3186622 — NO ctcatattaggatgtggacctgtccaaatcttcagggagtcctccctccccaggccaggcaatttctccagcaccaaggtaaccactgttttgttctctattgcta
tggattggttttgcttatttgtaaatttatttgtagacttggtccctatcactacgaattggttttgcttatttgtaaacttcatataattagaaatcatgaggcattttcat
aagtgtgttttcaacttctataaagagaaacacaatgtaccttcttttttgtgtcctaaaccttctttttctcagtccccttccctgtacatgcacttttcaaagtgatta
gaggtacagagaactcttcctctaatctaataaacaaaatgatacaaactcaataataggtggaaatgcccctcaggttcaatgctagagagaaactgcagg
gaatggtggggactatggcaaactatggaaa
1598 3720992 — NO catttctatggttattcgtggaatgactctttgaccacgcggagaaggcaaaacttcagccatttgtgtttttttccccttggccttcccccctttcccaggaagtcc
gacttgttca
1599 3916840 — NO tggcaatttcaacagttcgtcactgcacgctgcctcttaaagg
1600 3959370 — NO catgggcttctcagatccaggtgatgccca
1601 2571999 SLC35F5 YES tggtttcactcagcgcaggcgaatggctcttgggattgttattatctgcttgttgatgtgatatgggttgcttcctctgaacttacttcg
1602 3757901 — NO tatttccttattacatgttccagacaggagtgctagccca
1603 4002896 — NO ctttcatggagcaccgctgctcacgacctgttacagtctagaaaaatggaaaaactgaaaatgggtatctatgccacctaa
1604 4013965 — NO aaaatctactgtggagggagtgcaaa
1605 2327098 — NO atacttgagagtaaatgaactgctcttgttactttactatgtcaattacaaagcttaaaattcacacaagccacacgacatatttaagaatgcatgtgagggcca
ggtgc
1606 2381607 — NO gacatcagagtggaacttgggcgatgctgccaacatga
1607 2995272 C7orf41 NO cactcccgcttcagtggggtttctatggagttgtcttggtagcctttgccattttgaatttagagtccattttgtggctgactattctcttaagtttatgttggagaatta
acattcgctgactcgaatgtagagaactctgaatgtattaaggataggttttgagtcctcacaggtgaccttactgagggaaagcatggcagagaagaaatgc
agtctgcactttttatgtactttttaagtgtccgtaagtgaaaggttttgcttataaagcatgaattttaatatctagtcattaaactgcacaagtgcaaatacaaggg
caggaaaggataatcacttagctttggactaagagggtaagagaggcccagaagcctttaagtgttttgccattactgagttacctgggtatgtagcgactgg
ttc
1608 3261789 SUFU YES gctccaacctgagtggtgtcagtgccaagtgtgcctgggatgacctgagccggccccccgaggatgacgaggacagccggagcatctgcatcggcaca
cagcc
1609 3934119 SIK1 NO tgtgcgcgtgcattgattactatccatttctttagtcaacgctctccacttcctgatttctgctttaaggaaaactgtgaactttctgcttcatgtatcagttttaaagca
gcccaggcaaagatcatctacagattctaggaattctctcccctgaaatcaaaacctggaagacttttttttcttattttagttgagaagtttcataaactgctcaag
gattagttttccaggactctgcggaggaacggcaggaagaacctcagagagggcagaggtgacttcaaagtgctggggactccgtcctgagggtcacttg
gccctgagcccctgcgtgcccttgcggaagcccagaagcttcttcctgctgcacctcccgtttccgctgctgctgacgtttatgcatttcatgatggggtccaa
caagaacacctgacttgggtgaagttgtgcaatattggaggctgactgtagggctgggcagctgggagacaggctcatggctcatggctcatggctcagg
gcggtgcctgccctgggccgggacccccctccccaccccccacctaggctttttgggttttgttcaaggaaggtaaagtgagaggtttaggtcagtgttttta
agtttttgttttttttttaaagcaaatcctgtatatgtatctacatgggagacaggtagacactacttatttgttacattttgtactatacgtttgtgttccaggtttcagct
tccctcgctcctgttgttaagaagcgtccctgtcagcacaggtgtgcattgaggaaggggccccagggccttcgctccctcagcactggggtggaggcgg
caggaaggggcggcccttacctggcaggtctgggcgcacctttagcaggtggactccgtggggctccaccagccagaagcctctggaaggcaacgaag
gcaatgctgctccctgagtccagtccccgcccccaaacccagcccaggtgccttcagctacttcggcttcttaaaccctgcagtgtt
1610 2748304 — NO actcaaggtctgtccatgctggtgacttagagtagtgggatttaaaccagaggatgcacacttggaggcacttgaagatgtttcaagggacatgcaggcattg
aatatttaaaggaaattaattgccgattcttagatcttgagtgttaatcagttctaacactgaccgtcctgagaaaatgcctatggcccaggtgacctgctggtttt
cctttcacaccttctctttcatgattaccattctttaaagggaagacatacctttcacctaccccttatcagagtgccaagtagggggataattaaaatactgctgg
ggctgctgggaaagtgagtgactcta
1611 2358329 TARS2 YES ctccagcacccatgtcctgggggcagcagctgaacaattcctaggtgctgttctctgca
1612 2636804 — NO tcttatcacaacactgcggcgggaaaatcaggaaatgggttcacctttcagcagtcaccacagtaaacttcattgagaacatacatgcccagatatctcttctg
tgcacatgtatatgttaacagctagccattcagccaacaggta
1613 2907584 KLHDC3 NO cagggaagtcactaatgggagagtgggaggtatttgaaaagggggtttcgtgggtagtttttgtcctactttcatctctcttttgatcccgacag
1614 3185561 — NO gcgagtcgactcacctacctcttttcaagccggcctagccccttcccggaacctcggctcccccccaacgaaactactgctaagccaactggactacacttcc
1615 3752751 — NO atgggttcaagacctgtttatgtgcgagaacaacaggctttggtgctggtgactcaccaagatgggaaatacaggaaaagaagcagggatgtggtagcag
agtgt
1616 2366872 — NO ttcccatccctgctctagcagcctg
1617 2389086 — NO tgagagaggtttctattgttcactttagaaaaatgtaggtcaatgtaatgggtgatatctgttcttaattattctaagaattaaatcctgtatgttatcagtcacctatta
tatggcacaccctcagggg
1618 2523976 — NO aggcaaggggtaaagtccaggatgaggc
1619 3394423 THY1 YES gcagttcacccatccagtacgagttcagcctgacccgtgagacaaagaagcacgtgctctttggcactgtgggggtgcctgagcacacataccgctcccg
aaccaacttcaccagcaaataca
1620 3510096 POSTN YES agggagaaacggtgcgattcacatattccgcgagatcatcaagccagcagagaaatccctccatgaaaagtt
1621 2974447 — NO atggattacgggcttttatgtgggcagcaacttgtgcctcag
1622 3000375 — NO gtcacttttgtggcctcttggctgtaccttccctgggacaggacacggtcctttct
1623 3498077 — NO gcagttatgtatacacagggcaatcatcagaccataatcattactgttcgaggccagaacagagacgactagctctctgtgtgcctttcccaagtctcaccgtg
atggactgtcctctc
1624 3670758 — NO gtcttcagagctagccggctgtgtcttctccccgtttctttcactggtgaataacctttcgtttgaaccagccttgattgttctctccatgttccactgtggctcccca
tggacactgctaggtggaatctctgagaaaacaggcacttcgcagtcggcgcatctttctctgccagcttagggattgccgtcaaggtggaggaagggtatt
ttggccatgttcggagtcgttgttttta
1625 3418194 — NO cagttagctgtagagatgtgatttagcaaagttggttataaagtgggtttttgtaaattgatttccttattactgttctttgtagaattgaagatgtattctctcccagcaa
aatagttcacctgcagatcattgaaaagtttggctgaagaaaggggttattttggtgtgggggtaggaggcttctgtgggctgggcatggtggcttacatttgt
aatcccagcactttgggaggctgaggcaggaggatcacttgaggccgggagttcaagacttgcctgaccaacataatgaatctcccatctctacaaaaaga
atcagccaggcgtggtggcgcacacctgtagtcccagccactcaggatgctgaggcgggatggtctcttgaacttgggagattgaggctgcagtggagca
gtactcgtaccc
1626 3687863 ZNF764 YES gaggtggcgaaatgtcagacacaaacggac
1627 2438168 — NO gggaatatagagaggctgctgagag
1628 3059966 KIAA1324L YES ggctctctgtaccaacaatataacagactttacagtaaaagaaatagtggcagggtcagatgattacacaaatttggtaggggcatttgtatgccagtcaacaa
ttattccttctgaaagtaagggtttccgagcagccttatcatcacaatc
1629 3281916 — NO aaaaagtaaggtggatatgtgcagtggct
1630 2838994 — NO gtagaaaggggaatgtgtactgctagaggttacgggctttga
1631 2724513 UBE2K NO gtgtaccaagactagcaagagtttgcttcaggattttgttgaataattaagataatattttgagtgtgtcagggccattcaaattgttggtgttgcatcacagctac
cttaactgatttttaacatggatcctctgtgcctgtgaatttacttgcatgcttgtacttgacttcttaggatgggtagctgaaaagaccaccattttaagcatttgaga
attcttaaatatgaaatttattcagaattgaagatggtgacctattcagagcctttttgtccttgtcaacagactgggacagtgtctgattcccccttcacccccccc
acccccgccttgccacacacagctaatattctaatggtaaatttctctgtatcaggtggggaaatgtgctgaaggacagtatgtatcccttgcttcatttttaggtc
gtaggtttggaatgtcttgtcccagttcttcaaacactcttaaattttttcttaagtaatgtaaaaatggaactgccaattttatttctcttgcaaaaatagtaaatacttg
atgttacattattcccaggtttaatgaaagaacccaacttagtttttcagtgaatttgacacctattttttagtgatgaaatttttctttgagaactggcaaggatgcag
tcagctgtttgcagtttttagcctga
1632 2415597 — NO ccctgttaatcttgtggtcaccatacactcttgggttagctgtcaaattagggtttctccaccctgcttttgtataatgaagtttctaatcctaaatgcaggatgccc
cattctgagcctgtttgtatttaacagaaaatagggattttcgtcccatttttatcttaccaattcactccccaactgtgccagaatgcccagaggtaatagcctttt
ggaaggagctttcccatgctacattccagcagggtaaaacaatctgaaaatgttcttgccccttttatcactgagttctccatatcccaggctattttataaataga
atttttccctacagaaaatatgtaaagccattgcgaagagaaaacttttctacacatagaaaacatgataatttctcattagttttggaacaatacaggtctactcta
agttgtttcttattctggagtacaaaatttgcattttataatgtaaattgggacactgtatactagctttctc
1633 2818227 — NO cactatgtcaactgggtgtctttgctaagtttggcatcaatatggtgacctctcgggagcaggggaccactaggttacataaggaggggtgaactggcccag
attggaaatggagcaggtcaaaactcccatgctaaccagtagtgagatggagcct
1634 3412324 IRAK4 NO atatacacctatctcaaccatttttttaactgatttttttcctaaatattcttctttacctttaacaaggcataggctgttgcaggacagtggttattaaagcatgggttg
aacttccaaaatata
1635 3598210 ANKDD1A YES gtcggggccatatggctgtgctgcagcgacttgtggacatcgggctggacct
1636 3728164 — NO cttgctaacgctcgccagagaaatattccgtggaggtgttaaaacaagactagtggaaagaaatggtaacttaaaaagaaagaaaatccatggcagtgaag
aacagatttcatattagtactgtcataatattctctaatgtatcatataaataaaaatctgtttagaccagaattttaataagtcaccaaaggaaggttttgaatccta
cagtttatgtatccccctttgcgatgtaaatgttcacatctcaagtgaagtagagtggggagacgcttcggagactagaggctgttaattagtgaggtatattttg
atcagggcaagaagactggttcattctatatcttcgtatttctctggatgattatttcattttgtaaaatatgtaagagttcccccccagccccttatctttttaaaaatt
aaaatggtcatgctcttctaaaaagatgacttaatttgaaggctttggagacatgaggatgatggggatccatcactccctgttctttgctccctttggactggag
tgttggctgtctggaagagttttgcttgagctcgtgggttattttcttctatgtggaggaaccaagagactctttagcatctttcagcaagagcgaggtctgggtg
tactcaccatctgtcttaattatccttgtgtataagaaaacattcccatcttttcccaattgccatttccttccttaacttttagaggccagaacctcatctgttgatgca
gggagatctcacttctttaacctatttctagttgccttcagtcacagcggggtggccaggggcgagtcacttaagcctccccaaggctcagtttcctcctttgta
aaagagggagaattatagtactcactgcctgcagttagttgtttggaggataaatgcaaaattcttcactgggagtctggcataaaacagcactccgcaaatgt
ctgttgatcttattattatagaattattatttttattattattatttttaagacggagcctcact
1637 2779706 — NO acctggtaaagtgagaagagtgatcaggagaagataatttgcatagtatatatagatttctattccatttatataaaacccttgaatggtaccttagtagaaacaat
ataaaataaagctaatatgggttagatgataatgtggttaagtggatttttttttcctgtctgaacaaaagaactgacaatttaatcaatagacccctgtcagtctgg
agagatgcttctagtggtcagcacggcactctggtctttgtg
1638 3394582 — NO aacagctcaacatgtgtcgggatgtccagggaa
1639 2429120 TRIM33 YES catattttgaaagcacggtgtgatcctgtccctgctgctaatggagcaatacgtttccattgtgatcccacctt
1640 3428756 — NO cagctaaggtaaatctgcttggtccaaacaaaacaaaacaaaacaaaacaccagactgcaacaataacaggaaaagatcctcttcagtgatttatgttgttct
cttactttcataactagtttgaatgcaaggctggtaaagggatacacagagaatcattattttaaataacaaaagccattcaaaactctctctacctgtcaaggat
gttttatgctcccattcttatttgtttggcagtaaacataccttgcccacagtcgccagcatcaaacccacaggacaagacattgcatgcttggtcacagaactta
tcagcgagccaggaattcgcacatc
1641 3595186 — NO ttgtttaggcaaagcacgttatggctttttcttgcctagtttaggtctgtgcttaatgactactggaatagcagcaaacataacatcctgataacatttgggaggaa
aagccatatttgaaaattggtgaaatgcaataatctttaaaccaggaatcatcagtttgctaataaaaggtatatggctccaagttacgtattttgtcagggtcctc
tggcattttcactagtcattttgctagtgtgtacaatgattcctatcttgctgtaaaacttggtgatttttttatattgttgaactaggtgacatgaatattgagtcagatc
acataatcttagagtaacacataagtgattatgtagcgttgtgggtggaaacaattctggataaaaagtgcatgacagttcagaactactgtgcaggcagcctg
tctgaaatcaggtttaaaaattggccctgtctccagctgactcgttttgtc
1642 3959259 — NO ctcaagcacagtcatgattggttttgtattttcttctccaggctacataataattttttgacctggttttcttgatgccttataattctgaatgctggacttgtctctttatta
cctgccagttagc
1643 2604457 — NO acagcaggaatctgtcagtgtccctga
1644 2843218 PRR7 NO ggcgcgcgcacgacttgagacctgccacgggcagcccccggccgcgggtccccgagtgacgctggcggcacctgagagtgtggcgcgggcccggg
gccacgcagcggagcccagtgtccagtgaagcgtctgaggacccgccgcc
1645 3039818 — NO gctgacctattgctgaggactatgagaaaaaagttattacagaatgagtcatatggaaaacacttgcaaac
1646 3483658 — NO gcagacaatccccatcagcttaaggttcccgtcaccagggtttcccttcatcgaaactttgccacagtca
1647 3605805 SCAND2 NO tgtagtattcactactccagacctttttcaagttgaattttttttctttttccctatgtctgttcttacgtattttttttaaacttttatttcagtagtgtttggggaacaagtag
tgtttggttgcatggaaaagttcttcagtggtgtttctgagttttggtgcacccatcacccaagggtagtcttttttatccatcaagtctgtacccaatgtgt
1648 3659197 — NO agagagcctagcctgaatatgccacagccgcacagagtttctcct
1649 3775146 — NO cagttaagtgcagctcggtgagtcccggcagttccttcccggcactggctcgtccctgggttctcaaggttccatgcggccacagcgtccgtccacctgtcc
acgcgagccacatgctgaaatggaggtggataaaattcatcaggcagctgctgtaacacggaaatgtgcagatgccagagtagcttcgtc
1650 2534837 — NO tgtgcacgcatgcagcactgcgataacggggcagggggagttaggtgattgcttaaagcacaagtgtgtagggaagaaacaaaggcaggaggggccat
taaggagcctgtagagtgtttgggtcgggggctcacatttgtacagagtgagctga
1651 2705269 — NO aaagctacaagcatggccgcctgtggtatcgaggtgttgcaaacaatatctgtgttgcgcttcctgttttaacctacctcgttttgtttgtttttgtttcactgttcatc
acagcagtgttatctccaggagacatatagagagctcaaccggcaatctcaggtgcatttaacatttttaaaacgaaacagtagttgaccaatttttcttcttaa
aaaattggaagtggggggaatccaatgacaaaaactaatgtggcttgtttctggagaaaataattactgtaaatggaacaacaacaacaaaaaaaactacga
tcttactgactttgcctaaatacacaagcagctgatgtactattaatgagaacgaaatacacattaggaaaatggagccatttcaatctagtggtttgggcaaga
tggggaagagaaggggaaacattctagtttctggattacattattatgcccctcctgaaaaggtggttgtcatttgcatttatttaaagcaggtaatatgcaggaa
tgtaactgaggattatcttcaggcaatcagcaagatatcctcctcatggtccctttagctctcaaaagcaatgaaatcctcctgttctcatttttactgctgtggttgt
gctgctgaacaatactatcttctcaaattccatgccacaaattcagcaataactttttggattgaatttaacaactactgtaattggatgctgatgtggacaaaatat
attgatttcgatttcactcccgaatgtgattgccaccagctc
1652 3479382 GOLGA3 YES tcagcaaacagcccgtgggaaaccaag
1653 2320890 — NO gtttcatgagacagcgatctgcctaaccattcactcctcctagaagcaaaagctaccgtgatcattgaggcacagccggtcttcatatatcctcaaaggaggg
ggattagcttccacatcccttctctattcctggaggtgccagtagtgggagagtcatggcagaagttaccagaggcaagtggggcagaggcaagtagggta
tatgtttggatcagtggatcagtgtcctttattgtgcagaaaaagctaaaattacagattcttctgaagggatacatagcagccgtttcaccaatgtccctcagtc
catttgtccaggtccaga
1654 2824597 — NO tgtaggtgctgctttaatgcttggactgatgttattgttgtgggagtggattagttattgtgagcatgggttggttataaaagcaaggtcaaggctggg
1655 3916352 — NO taatgggcctgagtgtcaccaagag
1656 2900984 HLA-F YES ggaatgaatggctgcgacatggggcc
1657 3003162 GBAS NO ccctatgccgatgttgtcctggattaccttttttgtcctgtcttatcacttcgtctcctgtctcgggtttctggctgtctgttcctatttctatttgatgttgtgctctcactt
cacacccagcatgtagaatcaccttgctcttccaacttccctgtctgtgccactcaccttgttttactcagcccgttccttagttctctgtggtgaatctgtcaccta
agctgtgcattcttcatcggacatgtattttggttctcttgtttccttctccatctctctctccaagcctctcgagccccattcccaagtagcttttttttctgactaccttt
ctgggctccaagctatacctgtgtctccttcctgccctgcaatacattaccccaaagtttgtcagattgatctgcttgagttctgttttcttttttcatcacgttttttcttt
tctctgaaactttcagcagctccctgtttgcagaacataaagacttaactcctgcctggtttttaggggtcccaataatgggattctgcccaacccatccagttct
gggtacaagtactgcctgccttacaatctccattcaggtaaggccagggctcctaagagcaggtttggggtccccagcaaagaggagtggctacaaatcca
tgcgtgactttgtgttggtgaaaaacctgggccccgttgccaggcccctttctggaccccacctgaatcatgtgtactgggcttcctcctgggcactgcctcca
atgcagggttgtctattcctgctcatgtcatgcgacgaaaaggaaatgttggacatacatttccctagcagaatccctctttccctgtcctcgattttcattgatcc
catgttatttctgaacattcatgagtcacgcatcagatacatttaatatcagatcctaatttaaaaagtaaatgctactcttccaaaagtacacatgatgtggtcact
atactgggtcataaagatgtatgggttttcagttagttagacttagaccgt
1658 3743421 — NO ggaacaggagaagccccaattttcagaagagaggggagttgattgagaagtgtaagattgttacttgagaataatcttgagggtatgaaggtagggtaagg
gagaatggtgataaactc
1659 2949593 DOM3Z YES ctggcggcccagtcaccgtgtctgtacaccaagatgcaccttacgccttcctgccc
1660 3824798 MAST3 YES acggcagaagatggtccctcgcgtctctcccatcttccggctatggaaccaacacac
1661 3933890 — NO tctccgtaaccctataacagtccgata
1662 3340811 — NO catttatttatgatcaaccagagagactaaacagtggactcatgggtttggactctattgcaattcaa
1663 3888249 DDX27 YES gatgaagaactcaccaacacaagcaagaaggccct
1664 3932432 — NO atagggaatgtgctttgagctgttt
1665 3941419 — NO caggaaaagagttggcctggacctgca
1666 3976987 CCDC120 NO gttgactgcgtgtccattgttgttatagttggttgaatctgtcccattaattctccttcc
1667 2892314 — NO acatggccagtactgtttcaggggaatattgggtggcgctgg
1668 3379157 — NO gggccagagaactttacaatgattatgaagatcaaagggcattagaatcaagctataaagagccactgtttgatgttgggatgtgaggatgctgcaggtggat
gtctgcacgttgatggtgagaacatggtcaccctggccctgctgggtctttgctaaagagactgtgctctgttcttggggccgttttcatcacctgatta
1669 3830022 — NO aggacggtcggcgtgcagagttcctggagtgctggggggcctgagatggttgtatgacgtctggaggattcaggagggtgtatggggtctcaaggacac
1670 3904149 CPNE1 YES ccttggttcagctgtccatttcctgtgaccatctcattgacaaggacatcggctccaagtctgacccactctgcgtccattttcaggatgtggg
1671 2408020 — NO tgaaccatccattgcctaaaactccagcaaccctaaaaggacccaatcaaccagaagaaaaaatactaatacctcatatcatacagcaacctaacatttcaaa
gtgctttcacatgtgttagttcatgcacacctgacaacagtttaactgagggagccagggc
1672 2437930 MEX3A NO ccctgggtccagtagaatgtataaaagttgtaaggaaaagataaatagaggagggaagtggctgagtccaccctgagttgcccaatcttcagataccaggg
ttggatcaggttgctagtttaagattgggagcttccagtctgctggggttgattctgagaatccttggatttttaaattgtaggacaaagaaatgaggggttcattt
cccagggtcttggaaaggatgcacactgatcatctcaataagacaggggctgggttgggggcagcagaggaggccaagcacattcacctgcacccctag
tacctgggcagcccatactccaatgtggta
1673 3264854 — NO ctccacctctttttgtgcgagggcggcctc
1674 2701275 — NO acttgctggaaaaagtacatgctctcc
1675 3017578 — NO tatctctgatggagctagtgaacattaagccctcaatatttgtttaatcagtgctatcaaagtggtttaaatggatgtagtctccaggggtctctg
1676 3625878 — NO ctacttcagtgagtgggactttagcctgagca
1677 2438152 — NO cagctccctgagatagatgtaaatcctaagcattgtgggtgttttggtttgatgggactggattgaaagatttacagacttaaattgtaaaggaaggtaatttaga
gagaggaaggaaataaacattatgttggtttggttataaccactggcttgtctccactgacatggcctgggggtgagtggtgtatttgcaaagctcctttcaggt
ctgcattaatctctggcattagttggctgtgaccgattagcctcccagttaaagtatgtagtcagttcttagtgatggtaaatgggttactgaggccttcttattaca
tccaattatgaggtgactatataatttatcttgcaaactgttgagtgtgttctaaacagtatgctgtgggggcgctatcactaattatgctgga
1678 2786550 — NO gtacccaggaggtttggcatcactcaagaccctcagaatgcttcctctgctttaaatgcttggagtggctctctgtccaaactgtattaccccatccaaactaaat
cacctctcactatgtggatgaagcaaacaacagatcttttgtttcgaaatgatttcatgttaactatattccaggatattaagatcttacttaaggaaactgctttgc
agtgccagggatctaagctatata
1679 3122495 ANGPT2 YES cagggacagccggcaaaataagcag
1680 3252241 — NO cttctccgcaccacatcgcccttactctaaaattgaccacataattggaagtaaaacactcctcagcacaagcaaaataata
1681 2806568 — NO agagcactcaattcgactatccgtccagctttcacagaatttacttctgagcccacaagactcaaattgtataaggatagagtctgtttcattcatcaacatatcc
agcacctgacatagttttacatggcacagagtgggtgttcaataaatatttgtcaatgattgaacagaaattttcagcaccaaatgaaagaaacacatgactttg
aacaacggcacgagaataccaactgtttgattatgcaacgacaggatcttttggc
1682 3385452 — NO agttcctaaatgggaacactgccttatgga
1683 3968192 — NO gatcaacgcttaattcaaaaccaggctgtagaagaagaagaagaagagctaagaaggttcttagtgctgatggggagaagagaaggttctggagctgtgc
catccccgggtggaaagagggaatgtgttctttcttcccttgacacttctgtgcagatgaatcaggcaggaatcaagagcggttg
1684 2397794 — NO cttctgatcaccaagccacatgtgatgactcctgggcccttcttcctgggacaactgcaccagcttctaatcagctcgcccatctcagcctgacccctctctgc
agcctgaagtccagactctctagcctggcaccatagtcctttccttctctctgacctaatcattaaccataaccc
1685 2412877 ZCCHC11 YES cgatgtgacattggggatgcttccaggggaagtttatcttcatatg
1686 2904959 MAPK13 YES gtgggctgtatcatggcagagatgct
1687 3367083 — NO acagactgacagaggtgcatggtggag
1688 2762520 — NO tttaccatcgtttcattccatccatcc
1689 3463535 — NO tgcctgtagctccatacctgtataatcaacagctattaaatatctgctaagcaaactaaactaagcattttcaaaagtaaacttgtgaaacctgatggatttcagta
gttgacatcagcatctacttttgctgaagtcagtagcctggacattatttatgacacttatttttttttcccatcttgcccttatccattcattcaccaagccttgttgagt
ttatcactgagtatctcattgccatcacaccaatctaggacaccatcatctcttacataggtgattacaatagcctccacactggcctccctgtctccgtttagctc
atctcccaatatattttataaaaatgatactgttactttctctgctttaatggcttaccattacctttaaatggagtctgaatcagtggtctccaaaggggggtgatat
ataagataatctgctagggtgcaggaggaaaatattggaacttttattcatatttacctttttatttgaaaaacactaaggcattaatatttaaaagctactactgtgt
aatagttatttagtcattccttctttgctctatgtgtcagatggtcatttggtactaaaggtgtcctgagggaagcatgctttgttcactttctgcatgttgcacaatac
tataatttgaatgtccatctatgcggatttatgagttatctagtttaactattacaaaatatgtaagtctgggattagggaatttgtggagaaaatcaagtgtttaact
gcaaataagatcacattgttgttcagctggtaagatatacaaaatcaaatctgttctcatgaattaagaaaaattacgctgattttgaggttttaagtgaaacttttta
aaaaattctcatttttttgtaaggcatccctttctgctttgatagccattaaaaatcaaatattcaaactgatgttagaactagatctttgaatctctgtatcacacggt
gttaagatcttcagaaataatgaagcatattcaatatttta
1690 3533262 — NO tgggggagggaggatactactgagcaa
1691 3651809 — NO caaagatgagaggtgcgaagttgtccaagtccaacagctcaactgaactttcctaagtggaattgtta
1692 3719905 MLLT6 NO ggttttgcatctcatttacttctccattggttcaggataaag
1693 3744442 — NO ctgagcgtgccatctcccagtggcc
1694 3994048 — NO gcaagcagcttgtcagacgtgcatgtggtttgga
1695 2566874 — NO ttccctccaaagtggaagtgagctggagagatctctgggtctgaaagtcacctgctatgttggaggagggtcaggctttttgaggactactctggtcaaggtc
tgcagacttgatccctcctttaacccaaatcttattattatggctacacatgtgccacacattatagctccagatactcacgcaaggttc
1696 3788902 — NO agtttcttttggcaggtggtccagaa
1697 2684832 VGLL3 NO aacacaaccatttacgatctcagtcagcagatttactctactcaaggaaaaaaagaaacaatcttattggaagcagatgttgacactgtgtcagttattgaagac
ggaaggagttcacttgagccattgcagttacaaaggggtattgatggcagt
1698 2808743 — NO ggccaactgtcaagatgttttgaaggccaatctggaagtatatgttaaaataaagatgtgcataatttctaactgagcaactctactttgtggtatttatcctagag
aaacattcacaattatgcccagagagatatatgtagggtatcccttgctacatggtttataacaaaaaaatatattagccaactagggtccattagg
1699 3311746 — NO tttcctcagtgcattcttggtggtgagattgattggtgagcatcgtataacccactctgggagcatagcctatttgtatttgtgtatgtctatactttgtgaggtttag
cccacttc
1700 2398939 — NO atgaaatggtttggaaaggagcctt
1701 2948399 — NO agagggcgatcaggtctcattaggccccagggtgtctgaggggtgatctctgccagtggcggtgggcaaggcagaagaggcgtctgctgcagtggaag
gatcatgacagcctgagttaaattccacctcttctcagctgtgaggtcttgagtaagtgattttgctactctgagtcttagttactttg
1702 2974531 — NO tctcattttgattctggcagtgggcccaaatgctaagtgtcttgcccaaagtagaaatttccagttgctacttccatggtgtgccgcacaggcaatggctgagtt
ctt
1703 3385006 CREBZF NO tctggatgattagcacatggataaaggagatttctggaatataaaatggattgtttttgaaatttctaggtttggctctatttactgtaatggttgaaaacaatttagt
atttgggtgacccttttgtttttcttctaaatgtgcctctggtaaaatacagaactagactaaagatgtagctttttaatatttgtcttttgatggtggcaggagttcata
cattaattgaactaacacatcatattttgacctactatttctatcatattgacttactgtttctgcacttctttgaccagacttatc
1704 3777967 — NO gcgagtgactccgtttctttggacctgcggttgagctggcagcagaatggaggggtccgagaaacgggtgagtgtgaatcccttgcagaaatgctctctgg
gggtctgcccttgaatgttaggcggcatgacaagtcaaatgcagtccaccagggtc
1705 2446212 TOR1AIP2 YES atggccgacagtggacttagggaacctcaagagg
1706 2527475 — NO ccatttgagatgttctccgaggtgg
1707 3110892 — NO ttggtttcaaatggacagcagcaaa
1708 3229044 BRD3 NO gatgtttctggtaatcatggacccttctcc
1709 3518549 MYCBP2 YES caggaccaggttctcggttgtcatctcctaagccaaagactctcccagccaataggtctagcccatcgggtgctagttctccacgctcctcctcaccacatgat
aaaaatctacctcaaaaaagtactgctcctgttaagacaaagcttgatcctcctcgggaacgttctaaatcagactcttacacacttgatccagataccctccgc
aagaagaaaatgcccctcacagaacctttgagaggacggtcaacgtcaccaaaaccaaaatcagtaccaaaggattctacagattcccctggatctgaaaa
tagagctccctctccccatgtggtacaggaaaacctccacagtgaggtggtcgaagtctgcacctcaagta
1710 3701324 — NO caaattacaattcaggttctgtttgaggtgctcctgagaagaggaaaagagtcagaaacctacacaaagatgtatagaagattaggtcctgagag
1711 2941831 — NO ttgcgtttacatgacttgagtggcctgtcagtcccgctagtaaagtctcctcatccatccactctgtttaaacaatcaaactctgaaacctgtgtctcctggaccat
cctataatccctaaaataggctgttatgcttttcacctctgccctactctgttagcactaccaacttattgacctctttcaatcaaatcgttatctaaaggatacctgt
aactcagataggttgcctactgggcctgtttagtttta
1712 3403963 — NO ttttttctgcactatggcttgggccc
1713 2337265 C1orf175 YES gaaaggcaacaacaagcagtcacagggg
1714 2774211 — NO catcaggagtgtggattctgccattagtacccaacagatcaatgcccagtgtttc
1715 3626362 ALDH1A2 YES gcttcagaaaggggacgtctgttggataagcttgcagacttggtggaacgggacagggc
1716 3760869 — NO gagcgtctctccttcaaatacctggatttttttttttttgtacactggttcatagatcggcacttgactttgaacctggcaccaaaaggcacaatatctgataccctgt
acaagagctattagagatgctgccatatggatgggcaaaactgagccaatcccacttaggaatggaaggcttggacatggaagggaggatataaacgagg
agttggagaaaaacgcaagcccagtttttgctagagtggaaatgaaagtgggaatgagggtcttgtttttagtcctctaaggaccaggaagcaattttaaaact
tccttggtttttctgaaagcagcatattcaaaatgccagcaaaaactcctaacaactgcaaaaccaaaagaggatcaaagctcaccaacatcccttcttattgct
gaaaggctctaaaattcaggatgccctgttcccttgtaaaagggaaaataattaagtctgatttatggtaatcataccacatcacacttctaaaaaaatattcaag
tgtgtgaccaggggacgtttgacaccatt
1717 2772067 — NO cctcaaagtgtctaggaggcggtttgatatgcagactaaagtgaga
1718 3350159 — NO tttacatcatggtgtgtgacaaaacaattgcttccccctcctccctgcccttccccacccctgacttctaagataacta
1719 3946034 — NO aggtctgcccatcccaaacctgggt
1720 2699092 — NO gcttcaaacattggcccttcacgtacaacaaactctatcattcgatgtatcagggcgagcaaattcctacaacaacaacacagttaaagaaaatggattcaga
cctaccactatataaaactacacttgacctaagttactataattgtgcagaaaatgattattctgctgactaacaccgaatttaataccaaaaaagtaacctggag
catatgttaatgccttgtgcattaagagggtgtggggcagtgggagtagggaagtgggaggggatggaaaggtgagggagggtaggaaaccacaataca
gcctcatagtaatatttaattttctaaatgtcacttattttccaaaagtaaaacattaaattataaatcacaactaattagaaagctgcaaatattgatatataaaatca
gtaacttagagcctgcatgttattacagccatcta
1721 3027187 — NO gttcacggcagctcccaacaggtctgaggtaagacgccgctattatcctcgtttgctgggagaagactcgggcttagagcctctgattacacagctgcactct
aaccatttcctaata
1722 3496668 — NO tctcatgtacctcgtagtatacctactatatacccagaaaaattaaaaattaaaaactaaagaaagaaataattgcaaaatgtaataatgtctttgaggggaaaat
aaaaacttcagtgaaatactctaagaggggtttgatgcagagctgggggatgtgggaaagtagagataggaaagttgaggagggagggatgggttacagt
ttgccaaggacagaattacttgagagggtgggagcaggacacacatgtcagggcctctggaacaggaagaggttggtttatggcagaaattgaaagaatg
ctctcatacacagctcactttcctccttgctttttgtctgcatagcattattcaatatgtagcataatataagttgaaatcatatatcacctttgtggtcttctcccacca
gaaatcaggcattatgaaggcagaagggcagaggtatttgtcgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtttgacttttgtatttttgctgc
cgtattcctggtacctggaatagcacttggcagacaaatgtatgcaaagttattcaaatccagtgggaccagaccacagtg
1723 3718614 — NO cagtggggatgtagaatgtgtccaaa
1724 3759098 — NO ggggcagcacaggtactctgattttggggccacgagggccaaatccgcgcctgcacgtag
1725 2721510 — NO tattcctggactatagccgctgatctcattgatgcccttcttc
1726 2938424 — NO ctcaagagtgaacccggaaaggctcctaaggaggtccctgcctcagtccaggcaaggctgtggcctagacgaggtggcg
1727 3606484 AKAP13 NO tgctgctgcccgcatgggatgcgcaggggaggcgtggggatccgcaggagggtggttgggatacaccggatacctctgctctcattgcttgtttgcaaatg
ctctatggacatttgtgtgctaaatccta
1728 3750237 — NO ttcacccacatacaaaatagtgcgcgttttggctacttcagcctcttcccttctctagaaataactcctccttgtacttagtaaaggcacacattcacttcaagagt
agg
1729 3320010 — NO caggaggcccgaccaaaagcagatcaaataggagtgacagagttcagagctgcctgggacaaagttttaaattttattttcactgcaacccataggaagata
aacattttatatcatgacccagcacacaca
1730 3907649 — NO aggaatgggccgcatggactacctgggggtccccaaggccccagctcctctcctttccgcgccttctcccaacctttattgcagcgtctcctccggcgagac
gaggccgggcttagaaaaagggcagcgaagacccaggggccaaactggcactgaggagctctggtctctgcgcggcggggcgccctctccgaatcag
ccccaacaggcgtggcctccgggcttcaggcagcggggtaaggggccaggacacgggcacagggtctgtatgtaaacggtgacagcggc
1731 2546923 — NO ggctgtgtcacgtggacagtgtcacatctgcgggtggggataacaaggcacctgagtgcgtgaaggagga
1732 2788764 — NO ccatgggaacagtcttgcagtgatggacggtttccatcccccatcactgacgcgggaataactgtgctgt
1733 2886332 — NO cttttggcaaaaatgcgggccatggggtgtcaaag
1734 3307785 — NO aacttcaaactgtgctcatgtgggcacagaagcatcgtgcagggctgcactgtcaccagccccagcagccacagggcagtttgtcaccagctccctgaga
atcaactccagtgtgatggaggtgaccc
1735 2339825 — NO tctttaagcgagaagtagatgtggggaggggttgttgcatttttaaagattcctgtattaggccgggtgc
1736 2922550 — NO gtgaactttgtacttacgtgtgcttttgtggtagcaagtatcatctttctgtttccttttagcatttttggtgtactggtcta
1737 3319874 IPO7 YES tagcgcacagtttgacatgtcaacaag
1738 3571362 — NO tgggtactcgagcactgaagcattctcatcacttcccatgaagacactaatcccattaaactaggcattcctctttccctgaggttcgttgatagttgtatcttttgt
catttcccatagtgggaaaactaaggtccgtggagggggatgtgaatccataatttctcttcaacaaacaggcagcagagccattgtggaatttctagcctaa
gccataagatttgtggtttgtcctgatgtaagtgcattcactg
1739 2562256 — NO acaggcgggtatggtaatagcaatctcaggagggctcttctgttgctgtgtagaaaatgaaccaagtagcatagaatcgtgaccagctttccacacctggctg
gagcactcctggggccttcagtagggacagttac
1740 2599272 — NO ggaagttactgcttcccctggtgtctgttcttctggcttcagcttcgctggggatggattc
1741 3019543 — NO gtggccttttaggaactgtagagtaacttaatataagagacattatttggtgggcagaattaagatcttgggagccattgctggtgcaatcctcacttgggaaaa
tttaacaaaatatagttagaccttttccaggtctcacccattccatt
1742 3316144 TMEM80 NO gagggccacattcggagcctccgtccactccagttttatcagcttttgccttttgcacggagtgctaaacaaattctagctctgtgtttttttcccattcccagattt
actatcagttctccttaaaaagtatctaagctgttacagtagctttcccttcacttgattctattgtgtgttttctatgtttggaataattacacccaaatatctagatattt
tctcttcaccgcattttgtaaata
1743 3808909 TCF4 YES gtctatgctccatcagcaagcactgccgactacaatagggactcgccaggctatccttcctccaaaccagcaaccagcactttccctagctcc
1744 2360953 — NO acattctatcagagagtacatgatatcaccatgccttatcattggtgaagttaaccttgaacttggttaaggtgctgtctgccaggcctcttcactgtaaagttact
gcttttccctcttcatactctgttcttt
1745 2458084 WDR26 NO cagctgttctaggatcttgtcatttttactgaaagtctcgtgcacatgtgaagtgccctctgagtttaaggtttggttaatactggtatatttttataagattgaaattgt
gtccccatctttaacttaaacattttcattatcagggtcaatgtgctagaactgaattgtaacatttttaggcacagatggaaaaaaatgttattggctccttgaaaa
tgtgtgtgtgtggcgaggggaatagatccacaaaagcatgtatgtacttacaaaccaagctgtagagatcaagaaaagaacttaagtgttgatctcaagatttc
taaattgtcaagatttacatggcattgtggtggaactagttaac
1746 2775432 — NO tggagaccagataatggatgctggcaagatctgggaatcaaagccatggaaagggtgccattggtcag
1747 3577885 DICER1 YES tagataatatgttaatggggtcaggagcttttg
1748 2413468 TMEM48 YES gctggaggatagttgcaagtattgtttggtcagtgctatttctacccatctgcaccacagtatttataattttcagcaggattgatttgtttcatcctatacagtggct
1749 2478883 — NO tgaacagacctcaatgtcagacaagccaggggagcctgc
1750 2783808 — NO atatttttaatggtgtcagccaggcaaa
1751 2406967 — NO ctcctgtgactcagagccctcggctt
1752 2436718 UBE2Q1 NO tgctgtatttggatctcacgctgcctctgtggttccctccctcatttttcctggacgtgatagctctgcctattgcaggacaatgatggctattctaaacgctaagg
aaaaaaaacaaacacagaactgtttcaagtactcaagactgacttacagaccaaccaaccaccttgctggaacccttgctagcaggcattcttataaaagaaa
ctttcgagcctccttatattgctggaaactcagctgtgctccagactagagcctccttacctatgctatgga
1753 2663594 — NO ggcatcttatttcacgcaccacaggcccttgttcttcccagatgtcagcaggctttctccaataaatgcttcttcatttgctgttgcccttggaatcatcccagaga
ttttaaacggctgtgtgtatgtttcatggggaagtctgtggcctccttacactgtcctgcagaactggcacctccggctgtttt
1754 2854791 — NO tttagaattgactgaggagcggccgggtgcggaggctcacatctgtaatcccacacgccttgggaggctctgaggcgggtagatcacctgaggtcaggag
tttgagaccagcctggccaacatggcgaaaccccgtctccactaaaaatacaaaaattagccaggtgcagtggcacacacctgtaatcccagctactccga
aggctgaggcaggaggatcacctgagcccaggaagttgagactgcagtgagctgagattgcaccactgcactccagcctcagtgacagcgagactgtct
caaaaaaagaaaaaagtgactgaggaggaagaggccaggtggcaaatggaacagaatcaccaaagggtgaacaggactaaggcaatgtagtgtatgg
ctcagctacgtcagagtggaaaaggtgttattagagcagaaactatggtccctgcgtcacagggaagcaacctacagagaagcagcagctccccaagag
aggagagataagaagccagaagcctcagagtgaacaattgtccta
1755 3350791 SIDT2 NO tcagagtttggtgtattagaggaactgccagttgttcatactggctaggcagggccttacatttgaggggagaagggtgagagattgagctgggtggagga
ggacatgaaggcctttgggtgccat
1756 3447872 KRAS NO catcttcagtgccagtcttgggcaaaattgtgcaagaggtgaagtttatatttgaatatccattctcgttttaggactcttcttccatattagtgtcatcttgcctccct
accttccacatgccccatgacttgatgcagttttaatacttgtaattcccctaaccataagatttactgctgctgtggatatctccatgaagttttcccactgagtca
catcaga
1757 3709501 — NO gtccagtgcctcataacatggtctcaagctcttaacaaatggagcccaggattcaaaaatctgaactctaataatggcttgtcattctggtttcttacccttgagg
aacctgtgaggtgttaaccaacctgtaagctgcattccagcactggcaaacctggcctctcaaatatccagccaattctaagtttggtgccagga
1758 3606344 — NO gaaaaaattgtcagttgcagggatacatttctcactaatgaagaaacatggaaaatatctgtgtaaggggatcacgctgtttcttaagttcagattattggaaga
gggtggtgatgtaggtgtgtactcttcctgaggttg
1759 3884906 FAM83D YES ttctgtctggccaagtggttgaacactttgatctggagttccgaatcctgtatgcccagtccaagcccatcagccccaaactcctgtctcacttccagagcagc
aacaagtttgatcacctcaccaaccgaaaaccacagtccaaggagctcaccctgggcaacctgctgcggatgcggctggctaggctgtcaagtactccc
1760 3919041 SLC5A3 NO ttggaaacagaaacgaggcttattgctattgcagaaatcccaaactggcaaaggccagtatatatggtattccataatataaccagcttttgaaatttatgtgttt
ggattagtgccttctggttaccagtattgactctgctagtttgcacctttccgttctta
1761 2847683 — NO ctgggaggctttcagatgcagcatccaccaaggaatacaccgactaacacacatgacagcctgaactagcaacctgcatcaacacccctgcagaaaagca
gtgcatttcaactgctcatttaataagtatttgaattcataattacaaaacatcttctgtaattaaaccaccatatgcatttaaaatattttggggacaaagagtagca
aagaattatattggatattgactaaaaacacttatgaatatcaataatttgctcctcctcccttttcatcatagactctttacaatgatactgaccttggggttg
1762 3776975 — NO tttgcaacccaacctgctggaagtgcaaagttcagaccagcagcaagaactcttgccccatgcttctgctgacat
1763 3543413 RBM25 YES atctcgaaccagtggagcgcactcgtaacctggatcccagaaggtcgcgaaggcagtaccgtttcctcagcggc
1764 3653407 — NO ttgagtgtggtagtgtccgtctgtagtcccagcaactcaggaggttggggcaggaggatcacttgagcccaggagttcaaggctgcagtgagctataattgc
accattgcactcaagctcaggcaacagagtgagaccttgtctcaaaaaaaaaaaaaaaaatttaaacaagcgacagtaatatttcattagaaatgtgatgaat
gctatgaaggtgtagaggatgtctttagaatatataactgggagggagaccttttgagttaaggcaggtgctggtcaggaaagtcctgaggaagttacatttg
gattga
1765 3670580 — NO gtgaaagactaaacagacgacttcaaaactctcatccaacatccaagagttctgccatttccaagattcagcaatcctc
1766 3767260 — NO taccagttagtacaaagatcacagccaatatagaacctaaaagtattcacaatgaaaatgacaatgtagttgtcgttttgagctgcatggtacttaaatctg
1767 2456432 — NO cacctgctccgagggtcagggctaagtggtttgagcaagtggcaagctcacaggtccagttggctgagggcctgacccatgacgatccattt
1768 2750681 — NO tatgacactgaatacgggaaagtgatgggagtgaggctggttaaaatttttcacccacgcagtctccctgtgtt
1769 3071991 LOC653852 NO cacgtggtcactgacactcccatggc
1770 3436046 ATP6V0A2 YES actcggatccgcaccaacaaattcaccgagggatttca
1771 2383133 — NO tcagccctgtgaagatgtcattccattatcttctgtcttctattgtttctgtggagatggtagctctcagacaaattgttggttgctcgtttgtacatactccccactcc
catcctgccctgggtactctaacattttttcactttgtgtttagtttcagcagttttaagataacgtgcctaggtcgggc
1772 2434773 FAM63A NO actttccagccgcagagtagtgcag
1773 3338526 PPFIA1 YES gtttggagcaatgatcgagtgattcgctggatcctgtcaattggccttaaagaatatgcaaacaatcttatagagagtggtgttcacggagcacttctggcctta
gatgaaaccttcgacttcagtgcactggcactgctgttacagatcccgacgcagaa
1774 3671856 KLHL36 YES caggcagacgcgagtgtctcggccatacaagatcagcgaatcatca
1775 3060641 — NO ctcccatggctggataaaccaaatctgatacatccacatttaaggttgttttccaagttggtttccataaaaggcctttaacaataataggcttttaacaacaaaaa
ggtatccctcccatcacaatgagagcttgatgagggctcaaaagtgacttcaaaaactgtaaataattattttccttggacggctttaaaaacagctactgatag
caaatcagaaacactaaagaaaaaagacaataaggaaacagctgtttgtctagtgaatccataataaataccaatttgaggctatagattacaaagccaaaat
attcttataggaaagttaatgtttatatttacaatcccatggactaaaaaaactgtctaatatcttaaagactg agtctacctttatttaacattgtttatacacaaaga
cccaagggatggtagaattcttgatccttctggacaaaagcatagtgagaggggactgaaattaacaaaaagggaaaattaacattaatctcaaaattctacc
catcgttgtcttaaaatgatcaagactcagctacatctgagaaaaaggaaaaggatcagaagtgaaagaaatcagaagccagtaattaaaaaaatcataacc
ttgtgtgctttctactgacggcatttaaa
1776 3379623 MTL5 NO ctgtgcctaggctgttgacaacttttgctgagttggacagaataagactgtgggccatgctgcttgcttcactctctgggtgtgatggatcggtgagggtgcag
ttgctatgattgtaattggtcatctcatcatggctgttaacatttctggaccaaacaaaaatgacttcagctacttccagattctgctgatacattacacaggatgat
ctaaaaggctacagttctgaagatactcatctttcttgtaatctgggggcatctggtcaatagtattgcctctgtgctgtattgtgtctagaacattcaaggacattt
gatacttctcatactttaattgcgtgctctcccagttgcagcaccctctgaggcttctatgtgttgcagccgatgggcatttgcacagagcagcagtcatgacag
cgttttcagggcagctatttctccttttcccccttttcctctcccccggcttcccattctcctcctcctccttcctcttctcgtcccctcctcctcctctttgttctcctcc
ccctgctcttcttcctctctccttttcctccttctgtgtctatactagattattttcaatcagtcacatgtttttctttattttgaatgttacaaaatatttctctattgtaaacg
gtgtgccaggaaaaacatgagatgtgtatttgtattttttatgcacataattacttaatccaatgcctctccacttaattgggcctgatga
1777 3547548 — NO ccagtgttgggtgcaaatatacctaggata
1778 2779848 — NO atgagaagggtattggatacgattaggttagaagctcctagctcctcagtgaagtggtacataagggctctctctgc
1779 2869655 — NO ttctttttctaccctcactgtcctct
1780 2964686 — NO tctgagcacacctgtccagagagctc
1781 4004181 DMD YES ccttcagaaccggaggcaacagttgaatgaaatgttaaaggattcaacacaatggctggaagctaaggaagaagctgagcaggtcttaggacaggccag
agccaagcttgagtcatggaaggagggtccctatacagtagatgcaatc
1782 2432028 PDE4DIP YES atgtctaatggatatcgcactctgtcccag
1783 2443375 F5 YES tactcaagatcaagaagataacggcaattataacacagggctgcaagtctctgtcctctgaaatgtatgtaaagagctataccatccactacagtgagcaggg
agtggaatggaaaccatacaggctgaaatcctc
1784 2736714 — NO ttccagagtttgcagggacagttagagtcaatatgaattctcagaataagcactgccagatagtccggaagccctttacaaggaaagtgacatttttgctgtgtt
ttgaatagtgaacaagaatgtgcaggaagagaatgaaaggatatcactagcagaagaaatgcctctttgtaaaaccatagaaaataactctgagttgccatat
aggacatatgagaatttcagtgttactgaaacaaaagcttttggaaaaggtatggtgattaaattgggtatacaatctgaaaggtaaattgaggacaacttgtgt
gccagtttgca
1785 2969491 — NO ttgtagctgttagaagggatagttctacaaggtatccaaatttcctaagtatatttctttaaattttccttttattgaattttctgtttactggcattagtctcatatcagttt
tggctacctttagctgcttttgttgaattctatttaataaaggcactgcaagtataaaattattaaaaatagacaagcacaatcctttctctgctaaacaagcttatga
aaaacctggtgatacccaaagagctacaaaggaaactctcacacttg
1786 3417650 RBMS2 NO ctgcacttgtggaacatcacatggcaaaaacaggagttttttcgctagactttttttttctttttaaccttattaaaaatgagattggtcctaa
1787 2586174 — NO ctttgcttataatgttctgtagtgctgatggactgcctgattgtaga
1788 3777613 — NO aatgctgcaggcatcagtgggagag
1789 3888166 CSE1L YES tgacatcccgtcttcctatatggccttatttcctcatctccttcagccagtgctttgggaaagaacaggaaatattcctgctctagtgaggcttcttcaagcattctt
agaacgcggttcaaacacaatagcaagtg
1790 2332174 CTPS YES tgaattctcaagaaacgtgctgggatggcaag
1791 2684865 VGLL3 NO agaaccaactacagtcacctctgctacctcagcatgggctggagcctttcatggaacagtagacatagtgcccagcgtgggattcgatacag
1792 2756426 — NO aggcaatggcgattttaggctctccaggtgattacaatatgcaaccatgctcccaaatgtctgctgtaaaccaacatctttcggaggaccagttgaaaataatat
ttctcaaattaatgtgaaaagtgtttgctgttgagttgcggcctttcagtcccgcctttgttctctactcaccactgttgagttgtggcctttcagtcccgcctgtgtt
ctctactcacctctactgcttgttttgctcctgattcaaaccagttccacacatactaagcccactgtgctaggtggcctgaccgtggtgaatattattgtggagg
aaggactttgctgtaagaaattgcattccccaaaactgaaaccatgatatttactcaactgaggtaaaaaatgaaagactaagggggactcccaagggtcag
ggcaagaataaataccttggaatattaatacccatctcatgatgcctgagtgtaaatgctcc
1793 3309131 C10orf46 NO ggaaatgctaatttgagcttcattcataggggaacctactatatattgcatccctgctggttggaaattatcttcatctctggactgcattgtttagaaaaatgttaat
ggcttacaattctgagaactttattgtgtggctctg
1794 3435688 ARL6IP4 YES ctgacggatgagcagaagtcccgaatccaggccat
1795 3544550 LOC731223 YES tggaaagctttgaagacggcggttctggg
1796 3737293 KIAA1618 YES tgaaggcattgtctgcatttccaagaagcacctagataaatacattccttacaagtacgtcatttataatggggaatcttttgagtatgagttcatttacaagcacc
agcagaagaagggcgagtacgtcaacc
1797 2769855 — NO ttagtttgggtctgatctttgtttc
1798 2914869 — NO cttccttgtggaagttggcttgatg
1799 2754682 — NO acagagcccgagcttttgtcctgcaggctcaagcttctagattcgtcttctcgttaatgcggggacggac
1800 2353146 — NO ttccagcaggcaccgaaaaagccctgtgagcttctctctgagcggtggagaactgcacatgtatggatgttgctgcttcc
1801 2685210 — NO atatttgagtgtcttattggacttggaacttccaccagtatctccagaattattgtctgtctgcag
1802 2774664 — NO agttttggttccgacaagctgcaccattccaactgcc
1803 2517907 — NO tacacaaattgaacgcggtagggtgggggaggaagtagggagataaagcctatgctgctgattcctcaattataggagcagtctctaaaagccctcgtcaat
ctagtgatgtgt
1804 3156168 — NO gtgcaagctgtgtagtggatcattgagtgt
1805 3359979 NUP98 YES ggactctttggaaccacaaataccacctctaatccttttggcagcacatctggctccctctttgggccaagtagttttacagctgctcctactgggactactatta
1806 3701355 — NO tcaataaaagttgtattgagatgtgattcacatactgtacaatttatccctttaaaatatgcaattcggtagtttttagtgcattcacagagttgtgcagccattatcgt
aatcagtt
1807 2329396 HMGB4 YES gtcagctagaaaccggtgcagagggaaaag
1808 3290788 CCDC6 NO tccatgctcaagagccattgtaagagattaaggggtttctaggtttttggtgattttttgtttgtttttttctttgttttttttgggtttttttttcttctttaattttttgattaaaa
catacacacagctgttagcataaagtcgtggggggcattttctggaatgctcagcagttctgattaactgccaagcccaggttgcctctcatgaggcaactga
aaaaatcctgtgtcttgatagcatgggtgc
1809 3449856 — NO ctttgactccattgtctgctttggct
1810 3573894 DIO2 YES aggggaaccagagcgcacaagggaa
1811 3670649 — NO ccacgttgtcaagcacagaactataaaaacaatggattcagtgggtgaaggtaggagaaggggttcaagagattcagacttacagtaggaaagttatttttcc
aatctcagtaagttttttagggttatgaagattgagcactgacgacgctgaaataccacagtgcaaatgcttccgtagattccctgggctctgcactcaccagat
ccatttctatgataaagcacagagctcctcaaacagaacagtcgagttgcaggctcagcagcctccttgtcagtgtcctgctcaactcagc
1812 3851066 — NO tgcagtgcctggatcataactctggatcatcactgaaacct
1813 3912092 SYCP2 YES tccttgggagacctggcaaaatgaat
1814 2626159 RPP14 NO tctacttttaatcaggcgtggcagc
1815 3448099 BHLHE41 NO caccagctgtaaaagatcctatgcgaaagacactggctcttttttttaatcccccaaataaattttgcccccttttaggccatgttccattatctcttaaaattggaa
cctaattcgagaggaagtaagaagggtctgttctgtggctgagctaggtgaaccccggggtaggggaaagatgttaacacctttgacgtctttggagttgac
atggaacagcaggtagttgttatgtagagctagttctcaaagctgccctgcctgttttaggaggcgttccacaaacagattgaggctcttttagaattgaatttac
tcttcagtattttctaatgttcagctttctaaaaggcatatatttttcaaagaagtgaggatgcagtttctcacgttgcaacctattctgaagtggtttaaatggtatct
cttagtaacttgcactcgttaaagaaacacggagctgggccatcgtcagaactaagtcagggaaggagatggatgagaaggccagaatcattcctagtaca
tttgctaacactttattgagaaattgaccatgaattaatggactcatcttaatttcttctaagtccatatatagatagatatctatctgtacagatttctatttatccatag
ataggtatctatacatacacatctcaagtgcatctattcccactctcattaatccatcatgttcctaaatttttgtaatcttactgtaaaaaaaagtgcactgaacttca
aaacaaaacaaaaaacaacaacaacaaaaaacaagtccaaactgatatatcctatattctgttaaaattcaaaagtgaacgaaagcatttaactggccagtttt
gattgcaaatgctgtaaagatatagaatgaagtcctgtgaggccttcctatctccaagtctatgtattttctggagaccaaaccagataccagataatcacaaag
aaagcttttttaataaggcttaaaccaagaccttgtctagatatttttagtttgttgccaaggtag
1816 3872452 ZNF552 YES agcacgagagactgctccctacagaagaaccttctgtgtggtgtgaatgtgggaaatcctctagcaaatatgacagc ttcagtaatcatcaaggagttcacac
tagagaaaaaccttatacgtgtgggatatgtgggaaattatttaacagtaagtcccacctccttgtacaccagagaattcacactggagagaagccatatgagt
gtgaggtttgtcagaaattttttaggcacaagtaccacctcattgcacaccagagagttcacactggagaaaggccatatgaatgcagtgattgtgggaagtc
atttacccacagctctacattccgtgttcataagagagttcacactggtcagaagccttatgagtgcagtgaatgtgggaaatcttttgccgaaagctccagtct
cactaaacacaggagagttcacactggagaaaagccttacgggtgcagtgaatgtgaaaaaaaatttaggcaaatctcttcacttcgtcatc
1817 2489627 POLE4 NO gtgttctgcataagtggcttcctga
1818 2934111 — NO tcaagattatatatggcagatgaggataa
1819 3181290 TMOD1 NO gtaatggcccagcttagagacttcagctactgatctcatcacttattagacaaattgctgctgaccttacgcctgtatattaagcctccgcaggatgccggacaa
tggtgaagaaactccagatatcaaggaattgggaaatcctggccaaaccaccccaagatgattacactgaaatgtagtattagtactgctgccagatctcttttt
aacatcatgtgcgtctcttgggatccagcaaaagtgttaagccacaatgcccttgtgccttttaatataccacagtgccagttaaactaatatttttgtttgttgcttt
tgggagttattttcattagtgatttcagcaaatctcatgataaaggacaaggtcaagaactccagagcactgagcagagaggctggtgatgaaaaggtgaag
gcctgcgcactgaactgtaa
1820 3487237 AKAP11 YES aatgttccctgtgccaagttcacaagtg
1821 4009127 JARID1C YES tgagtgtccccccacagtagtggtgaaggaggagttaggtggggatgtgaaggtggagtcaacatcgcctaagaccttcctggagagcaaggaggagct
gagtcacagcccagaaccctgcaccaagatgaccatgaggctacgga
1822 2750647 — NO tgagtacagcccactgattgacattcaagacccattggaaaaatcaggagacacaagagtgggaagagtgcagattggagcagctatccaaaaataca
1823 2916198 ZNF292 YES gggctggacttgctacctgtatagaactgtgtgtaaaggctcttcgcttggagtctacagaaaatactgaagtgaaaatatctatttgcaagaccatttcatgttt
gttgcctgatgatctggaagttaaacgtgcttgtcaactgagtgaatttcttattgagcctacagtagatgcgtattatgctgtggaaatgttgtataatcagccag
accagaaatatgatgaagagaatcttccaataccaaattctttacgctgtgagctgttacttgtattgaaaactcaatggccctttgatccagaaactgggattg
gaaaaccttgaaacgacaatgtcttgcattaatgggagaagaagcatccattgtgtcttcaatagatgaactaaatgacagtgaagtatatgaaaaagtggta
gactaccaagaagagagtaaagaaacttctatgaatgggctttctggtggagttggtgctaattctggccttcttaaagacattggtgatgaaaagcagaaga
agagagagataaaacagttaagagagaggggatttatatctgctcggtttaggaattggcaagcctacatgcagtattgtgtgttgtgtgacaaagaattcctt
ggtcacagaatagtacgacatgctcagaaacattacaaagatggaatttatagttgccccatatgtgcaaagaactttaattctaaagaaacttttgtccctcatg
tcacactgcatgttaaacaatctagtaaagagagactagcagctatgaaaccattaagaagattgggaaggcctccaaagatcacaactaccaatgaaaatc
agaagactaatactgtggctaaacaggagcagcgacctataaaaaagaatagtctctattcaacagattttatagtgtttaatgacaatgatggttcagatgatg
agaatgatgacaaagataaatcctatgagccagaagtgattccagtccagaaaccagtacctgttaatgaatttaattgccc
1824 2984592 SFT2D1 YES tggcttccgggcggcataaagctttttgcagtgttttataccctcggcaatcttgctgcgttagccag
1825 3123564 — NO cagttcattccgtttccacctggcagctgctccctctgacacccaaggactcgcagggagtggccgttggacctgcagacc
1826 3165879 TEK NO gtagcagccagtcccgtttcatttagtcatgtgaccactctgtcttgtgtttccacagcctgcaagtcagtccaggatgctaacatctaaaaatagacttaaatct
cattgcttacaagcctaagaatctttagagaagtatacataagtttaggataaaataatgggattttcttttcttttctctggtaatattgacttgtatattttaagaaat
aacagaaagcctgggtgacatttgggagacatgtgacatttatatattgaattaatatccctacatgtattgcacattgtaaaaagttttagttttgatgagttgtga
gtttaccttgtatactgtaggcacactttgcactgatatatcatg
1827 3887555 — NO tccattccaggattggtgctgaagcacatgtgtcctgaagttcaggacgtcagggtaattgacacagaagaaa
1828 2356740 — NO tataatctagaaacattcttcagcgttttttttctttcattacatgaagagtcaagaccagtggttttgtggaatgcatgataatctgggttcttaaaaatcatttcttctt
gattagatttcccattgtcttgaattgactcagtcagcctttcctcaccgctactccaggttcactaatg
1829 2665536 C3orf48 YES gagaatggataggcttttaggtcttggaagaaaagaagtgtccagggttcaatggagtggctgctct
1830 2833553 — NO ttttggggatgacattgtggaaagtttaccctca
1831 3242698 — NO tgtaatacctcatcatagatatttggggtgcccttca
1832 3911222 PMEPA1 NO gaagttctagccactcgagctcatgcatgtgaaacgtgtgctttacgaaggtggcagctgacagacgtgggctctgcatgccgccagcctagtagaaagttc
tcgttcattggcaacagcagaacctgcctctccgtgaagtcgtcagcctaaaatttgtttctctcttgaagaggattctttgaaaaggtcctgcagagaaatcag
tacaggttatcccgaaaggta
1833 2676501 — NO attgaagaaccgctgctggagaact
1834 2839345 — NO gcagccttattcagcaacgctggggatgacaacatg
1835 3239038 — NO gaataagcagaaacggctgggcgtg
1836 3475695 ZCCHC8 YES cctcggaatgctgctcgaataagtgaaaagagaaaagagtatatggatgcctgtggagaagcaaacaatcagaatttccagcagcgataccacgcagaag
aagta
1837 3563672 — NO gttctgaggcccagcaactctgaga
1838 2333149 CDC20 YES acctgaaccttgtggattggagttctgggaatgtactggccgtggcactggacaacagtgtgtacctgtggagtgcaagctctggtgacatcctgcagctttt
gcaaatggagcagcctggggaatatatatcctctgtggcctg
1839 3740914 — NO ctggtgaggagccgcaactgggcatctcc
1840 3949524 — NO ataaaacatctttgacgtgggagctgcagtactg
1841 2598329 FN1 YES cattgtctccaccaacaaacttgcatctggag
1842 2354732 — NO gggtgtcatggaatcttaggagccctgcattccaattgcccaggctt
1843 2534399 — NO cagaatgatggagtttgcatggcacagt
1844 2677654 C3orf63 NO cagtacctgcgcaatccttgatttaatgaaattaaattttttatttcaaaagataggcttctgtttatcaaaggcgttgaacaatttgatttttaaattagattttgcaaa
atggaagtataatgggaatatatttttgaggtggtcttagtagtaattaccatttgttgaacacattaatgctatactagacagatacagtggagatagctttcaaa
cccgtatctattcctaactactgcctctaatactaattactaacttgttactaatgctaacttttaaaaatgtttttgaaaattgcaatttctacaaataaatgtcatagtg
caaataaatgtcaggatttagagaaggagcctaaactgaatttgtgttatttcagtaaaagttatggagttatgggtctagacgtgttaataagttagacagaact
ttggcactttagaacaaatgcatgagtggtatttcagttcctaagttacataaaaagtgtgaaagaacactgtgaggtcccagcaacgccagactatattaagg
taagtagaaagtgtttttatagggcttcaatacccaggtggtgacagagcagaagaaccggtttttttttttttttttttactactaagcttttacaaaagaagtatctg
ttttattgtatagaacaagtacagcattttactacatagtatacaagtttttaatgagcatttaaaaaaataagtaaatctaggctatttgaaaaatacagttgagcca
gtgagcacattttataatttggaagacacaaatcaaatgtgaaggatttgattttctacatttaaaatgaagaaccaaaactctcttcttgattttcagctaaaggca
ggagactactttccaactccttttgcttctggagaaggccctgaaatcacattgatatatgtttgttagtaaaatgtgcacacctgacttgcaatgttgtgttaaact
agaattatattcacttggaaaacatatcgcttaggataaaattttgtca
1845 2495347 — NO agaaagtcttaatgggagagtgcccatggtatat
1846 3436411 — NO caccatccttgaggggtcgagccaggactggaacctcagtccggccactacaacttcataaataccatcgccctgagatgctgaaatcccaggggccccc
caccctcagaccaggtgccggtattg
1847 3630941 — NO tccctggtatgtacacgcattcctgtgttttgtgaaaaaccgacaccatgctcctccctcactacatgtaaaacacttttattcattaaaaagaaaactgactggct
tggacctacaaattagtttcattatttgttaatgtttgaaagccattaaaagatgaatattaaggtttctttatactcaatacttgtagttttgtttgggggaatgagag
gatgcccttggtacctttgtgaggcctctccactgagggtcaatcatgacttctgttttaaaccagcccatcccatcttctccagctgctctccttatgtcttgcttct
ctcccctccaaccttctcagcataaggactcaatcctaggctcctaccccagacgggtgccttccaacgttcctggtgc
1848 3886257 — NO cacttgggttggaaactctggcttctttccccccatggcctgtttggctcacaggtgccaccagcctcaccttgatccactgtcacttgtgcttactcggtgttag
ctgctttgcctcctttcagtccctcgaaccctgagctcttctcagagctcctagtgctcctctgtcggcctgcagtgcactcccgcttgtgcctattgtgta
1849 4004292 — NO aggatgaattctcaccaaccatatattattttccgataacagtgtttggtagtgagggggatctattgctaggtaaaatacgatggattcaaggagcttactgtttg
atgatagggcaagatgtgttcatggatactagattgaga
1850 2960481 — NO ttggagccagtcaggcttttgtttagacattttaactttttcttgctttccttgcaaactcctcagccttcagactggttggaaagtaaatgtacaatcttacataaattt
tcaggtaatagcatttcagctttttccccaagattttttgcttgggaggagacagattagactggattcggagtcttgattttgcaaaggtaacaaaagacatgttt
ttttataagacttttcatcataagtttattttattcaacagaagcaaaatctaatataatggaaaaaataaagatctgtgataaatctgatctgtgtggataaacacaa
ttagaaagacttaaagattaagtattgaaacaaactaccaaaatattttaatactgatttgtaaaaatttcagtacatttttctcttgcttaattctactgggtcctgttt
1851 2977359 — NO tagtcattggtgaagcaggattccaa
1852 3199214 — NO tcaggcttctgttgcaagccaatgtagggaacca
1853 2743060 — NO ttcctgagttcaagatatagttaagtttaaataataggacttgtgtatgaattggatggtgtgggagggaaatcaaaagttctgggccgggcgcagtggctcac
gcctgtaatcccagcactttgggagtctgaggcgggcagatcacaaggtcaggagattgagaccatcctggctaacacgctgaaaccccatctctactaaa
gatacaacaaaatccgggcgtgg
1854 2811122 — NO aggagttctccacatactctgcccaccctgatagcaactgaggtaggccagaaacactcatgcactggttacctcctgagccatccacagaaagggtca
1855 3560070 — NO gtgtgatcaaaaaagtggtcagtgtgaa
1856 2597541 — NO acattgaaattcaagatgcaggcagagaaagaggacatagaccagat
1857 3747622 — NO gcgcgtgctcaacttggatgggacacacctagtctttcttcaagtccctggattcaaagagcttcaaccgttcttgcaccgtcaggc
1858 2332216 — NO ttgattcatcctatccgtgagcgtgg
1859 3029849 — NO gctggcaccccagaagaagctagctcagcatgtgcgggtc
1860 3090304 ADAMDEC1 YES atacattgatctctatttggtgctgga
1861 3441298 — NO actatctgaaaatgggcaggtggtgca
1862 3584491 — NO tgcgatctccgctcaaaaagatacttttgaatccttttcaaaagtaatttgtgtttcattttttaattagtatgataagcacttcaagaccctttacaattctggctagat
ttggttgccatatttaatagcattttataaataatggagaaaagggaaacattatgcatgcttgattacggtcatgagctgcattaacaattccgttcaacaacaga
ctgcatatgtcagagcagtcccttaagattacaaa
1863 2775809 SEC31A YES gtaaactttgaggatgattctcgtggaaaataccttgaacttctaggataca
1864 3380586 SHANK2 YES tttcgatacaagaagcgggtgtataaacaagccagtctcgatgagaaacagttggccaagctccacacgaag
1865 3410510 — NO tgtgtcccgcagctcaatcagacttctggatgccatcaaggaggtctgcatgacctaaggatcattgttctttgaaaggaaaacaagttcattaatcttactggc
tgccagggttaggatgcaaagttaatcaattattagtgactaccgtctaccgaatgactacgtgcaagcagtcatgcatggaggaagaaaaggacaaagag
aaaggaaaataagtaaaaaacaaacgtttaatgattttgataatataggctcagttacatcaccacaaaca
1866 3266758 — NO gttctggaactcttcacacctgtgacctgcat
1867 3878506 SEC23B YES gaaactggagcacccatcctaactgatgatgt
1868 3189392 — NO tgcaagattcttggatcctcgtccggtacattttggctgcattttatgtgacgtttgtgagggggttagaaatactttaaaatttcagggaacttgaataacaatga
aagatgtgcagctagtccaaacagatggacttcagtagcaattccaggggcgtttc
1869 3737624 KIAA1330 YES ctccctgcagaagcgtcccgacggccacatcgtgagtgtgag
1870 2587558 SP3 NO tagccgctctcgaaaacctacgctgccacggccgctcattgtctctccccttccacccgggggcaaacaggaagcgcgccgcctggcagaccgacggac
aggcgcctggaccaatgagcacagccgacaaagagcacggcggcgaatga
1871 2636399 BOC YES gccctacgtggtgtcgggctacagcggtcgcgtgtacgagaggcccgtggcaggtccttatatcaccttcacggatgcggtcaatgagaccaccatcatgc
tcaagtgg
1872 3383004 RSF1 YES aactgccagtcatagtgaagctagaaaaacctttgccagaaaatgaagaaaaaaagattatcaaagaagaaagtgattccttcaaggaaaatgtcaaaccca
ttaaagttgaggtgaaggaatgtagagcagatcctaaagataccaaaagtagcatggagaagccagtggcacaggagcctgaaaggatcgaatttggtgg
caatattaaatcttctcacgaaattactgagaaatctactgaagaaactgagaaacttaaaaatgaccagcaggccaagataccactaaaaaaacgagaaatt
aaactgagtgatgattttgacagtccagtcaagggacctttgtgtaaatcagttactccaacaaaagagttttgaaagatgaaataaaacaagaggaagaga
cttgtaaaaggatctctacaatcactgctttgggtcatgaagggaaa
1873 3959450 — NO tgtttttatcacagggccgtcgttgaagcatgtatgactatgtgtgtgaaaatgttctgcaaaccaaaaagggctcaggtgctataatt
1874 3984482 SRPX2 YES gatgagatgccacgcactaccattcatcactagtggcacttacacctgcacaaatggagtgcttcttgactctcgctgtgacta
1875 2333884 — NO ttgtagagtatgaacactcctttactttcagcaacgtcggcatctccaaataa
1876 3392870 — NO atgcatgagggcacgcctcctactttc
1877 2395894 CLSTN1 NO gccgcgcggtttcccttcgcagatgtgtat
1878 2701311 — NO attgagcctgcccatcatgcattgcaacaggaaggtggatttgaaaagggaaaagaattaaaacatcccatcacacgtgtaat
1879 2976681 — NO cagatacgggtgtgtacttgaatcaaggagaggcagtagagcagccttatgttttgttccccaaagagtgagatgtgtacccaattcttgcacatagtgaaga
agctgttctcttttttgttgtttgtcacatctgattattcatggagaaagttgcagcttggggctagtaaaatttttttttaacaccgttctcatattatttgctctcttctttt
aataaaggacagataggccttgatgtggctgtaa
1880 3398768 — NO gcaactttcagtggaggcgctgagagcaaattgcagcagagatgcgctcagggtgcagtaacaaggaaggacccgctctccgtgtcagtggcctgcagg
ggaagtgagaaccgggctcatgctgggctcctctactttgcagggtttaaggccg
1881 2376766 SRGAP2 YES actacagcatgaaggaattttccgggtgtcaggatccca
1882 2648351 — NO ggagcagcttcaatcaaaaggcggggctt
1883 2855376 FLJ32255 NO ccttttctgggggatcctaggcagaagcgatggcaggacaa
1884 3715585 — NO aatcaccatgacaggcagagtgtgggca
1885 2432021 — NO agtttagttctcttacgtgtggctagccaat
1886 2527209 RPL37A NO tttttataatgtgtctaggctgggt
1887 3753258 — NO ttgagctgcccaagccacctagagg
1888 2607727 — NO gctgtgcgaatggactcagctgcccgaactcacagaatatcagtaacagcaccgaaacttcaca
1889 2970557 HDAC2 YES gctgtcaattttccaatgagagatggtatagatgatgagtcatatgggcagatatttaagcct
1890 3233715 LOC399715 NO ccttctgcaaatggggatgagtcctc
1891 2555212 PUS10 YES catgctgcatggttgctggtaaaaca
1892 2601671 DOCK10 YES tatcctggtggagcagctatacatgtgtgtggagtttctctggaagtctgagcgatatgaactcattgctgatgtcaacaagcccatcattgctgtctttgag
1893 3630677 CALML4 NO tgggcctgaaaacttggagcaattaattttttttaaaaagtgttcttttcacttgggagagatggcaaacacagtggcaagacaacattacccaactatagaaga
gaggctaactagcaacaataatagatgatttcagccatggtatgagtagatcttta
1894 2677724 ARHGEF3 NO ggcgccatcagccacttttagaagccatcagccagtgtgttgggaaaagaggtttgtcaagtgttggcctatgggaaggtggtcaatgaatgttttga
1895 2898386 — NO tggaggcatttaatggcgatgtgcaggtgcaag
1896 3412766 ARID2 NO catccacctcgaaagctgggcattaacgatattgaaggacagcgggtacttcagattgcagtgattttgagaaatctttcctttgaggagggcaatgttaagct
cttggcagctaatcgtacctgtc
1897 3975856 — NO tggaatgtacctggaatagggaagtggacagtgagggc
1898 2466297 — NO ccaggtcgcacatcagctgcaggcacagccagttcatgggtagacagccacatcctgccccaggaggagggcagccagcatgggcgatgcaagctcc
cctcgtctggaaccagcacaacctcaggcactcgagccttggcccctcacaagcaacgtcctcaatgggtggcgttcgttcat
1899 3240817 — NO tccatcgattgactgcgaggggctagggttcacagcaagcagaacgtcctgggtttctcttcaataccacctcctcctctcctgttcagatgctgagaaacatc
tggcgcagtagagatgctgcctctgacatttctatgacaaaacgcgtgcctgtgctagggtttgcacaggcacaagttatcacaacctcgggatggggctg
1900 3454311 LASS5 YES catcacttggtcaccattgggcttatctccttctcctacatcaacaatatggttcgagtgggaactctgatcatgtgtctaca
1901 2437092 DPM3 NO gggagtgggtctcaaatatagagggggtagcaaggtggaaggggcccttccaccttttgtgggcactcaagttcggacctctgggatcggcgattccc
1902 2683293 — NO catctgtgcttgacgcagaggcctccggggtcgcgagcttcggaggtggaggtgccccgtcttcgggttcccacgccgccctggcgacctggggctcca
gccccaccgcggactccggtgggacgtgggtggcgcaagcacaccttgcccctgtgactcagcttgagggggcccaagctgtcccactgagcacgcgc
ccagcaggccgtcgcgctgcgggtcctggtcctcctgtcatttactggggtgcggaggcctccgaggagtctgagggtgggacagtcccacttccggag
gagctagggcagggaacacaaagtcccgagtgccggggca
1903 3701415 — NO ccataaaattcgcatggtgaaatgcacgtaacataaaatttaccatcttaaccatttaaatgcacagttcagtggtatcagatacattaata
1904 2590322 — NO ctagaattaagatatgctgatgagttgcttctgcagttcat
1905 2973489 — NO tttggcgtttgctacagaatggtgaatttatgtatttctcttccactttgacatggacattgcctcattcttcagtagtgtgcatattcaccttaatttattcaaaagctat
tttacctttttcaataacaccacatcaattaccttaacttattcacttacatcagtcttccc
1906 3020769 — NO ggatgcaggactgagtcatgccact
1907 2807755 — NO gagtagatgtaactaagaggtttgagaaaggaatttcagcagagttattgaaggagaagtcaaggagaggagaaggagaggagcagtgaatgttgtcgtg
aagaggtgttgtcttgaaatactg
1908 2918704 PRDM13 YES ctctggagtggatagggttaatccgggcagccagaaactcccag
1909 3024096 — NO taacaatatgtgcaggcaggaccgaaaa
1910 3270274 — NO gggcgctttcccactgttctagacgtaggagagaaagcacttctcagatggtgagcttttatcttccaatcttgtcaaccgaggagacctggaagttccctttca
acctggaatgtgagccctgcttgctgggcacgagataaggaccaaggattgacccaggacaatttcagagagcacaggggtggcatatcctcatgtcagg
gcgtggagctaatattcaga
1911 3356025 — NO atggcccagaatgggttgtcagtgctccag
1912 3913713 YTHDF1 NO ggaccgttgagctcactaccacctggagtttgagttgaagcatgaaaatggtgcccatgcctgacgctccagcgcctggatctgcacgtgcccttgtagagg
atccttaccgtcctagagagcagacgctactgaaaactacttgctccaaaagaccctctgagttaacgatcagctgtatcattagacttgtatttagagcgtgtc
acttcctctgaactgtta
1913 3506761 — NO tgtagtgttgctgtatcttccatcgtacagtggaatggcatcttacagaaggggtttcggtcctatggttagcttaatgttgaagtcagggaaagtcaaaatcacc
attggaactcccttcaactgtctataaaatacactatgcacagtaccttggtttacgtatatttgcataaatacatactttgtatagtcacatgttgtatgacaacttac
tgagttgttcgatgaacaactctatgtgctaataataattttgatgtattaaaatgggaaagcatttgcttaactgagtggagaggcacaggttgctgagtcagac
gtatctcctgttgcacacgtaccttcaggatgg
1914 3888725 PTPN1 YES gcagatcgacaagtccgggagctggg
1915 3357756 — NO tctgtccagagtgcaaggccgaaccagaggacacacatgatcatttctattttagaaacacgcctggggcagagaggacagcaggtgaaagagactgag
agagaacagtcagaggctagtactggccaagacaggagagtgagggagcaaccgtaatgaggatggatgaataatttgagagagatttaggggtaacga
accagactcactc
1916 2371244 — NO atgagctcaccttgcctgcaactgtctct
1917 2660674 — NO tgcccatttttctacggcttgttgatttcttgggagttccttgtaagctttatagtctctgtaattaatgagttccaaacatttttcctagtttgtcttttgtcttttgtttttgg
tgtggtgtgtcaaacagaactgtttttttgttgttgttcttacatagtttaatttttaatgcttctgtattctaaatcatagccaaaaatgacgttcccatgcaaaggaat
gtctcatgttttctttggatacttgctgtggtttcattacttttccgtggaaagctctgatccttgtgcagttgatcctgatataa
1918 3199144 — NO tagaatgtttgtatattgctgcctggc
1919 2411720 — NO agatccaattagagccagggtcagg
1920 2682075 — NO tgataatagggacgttgtcagacccttaactaagccacacactgctgggagcctccggaataactttaatgtagttgtagggaagggagtcgaggcaggga
tgaggatccctgcttgactgctctctttcctgacgaggaagaaaaggacagtgatcaagcacagggtctcaaaggaggtctta
1921 2709855 — NO ggacagcattacggtggacagtgaa
1922 3016026 MUC3B NO ctgcaaaacgggtacagcattcctgtatgatagctcacgccgtcgttgtgaaaaccacatagacttggtcaattctcggtcctactctgccctcccgtctcagc
/// cctcgtgttgccattgc
MUC3A
1923 3550736 LOC730217 NO accactacttcatgcagggcagtgtgcc
1924 3059100 — NO ggaagctaccaaggagactattaaagaaattcaggatggtgaagacagcttaaagggaaacagttctgcaaatagaggcgatgggagatataggaaaga
gggactatgtgtaggtcttgttgcgtcgctgaag
1925 3379723 MRPL21 YES tggttggggcagacaacttcacgctgcttggcaagccact
1926 3432355 — NO cgtcgtggatggatcagttttgctcgatagagggacatgtttttctgtggcaacaggagggcaaaaggagaaggtggccacagatgccggtagatgagctg
agagtgattgtattccctatcctctcggaagcttgaggcaaggccatcaacagacaatcagagggaataagaagagatagaatatatgaagaaagggaga
aaagatgaaatcgtaattgtgtagcagggcaagaagtccagaaatttctgtgctgtgccaagttcccagttgaggcggtga
1927 3511352 — NO ctgacggtttaagatgctgcattttaagtaatgctgagttgtatttttatttcagtcattcatttctacttattttgagcacccattatatgttaggttccatgctaggcac
tgtaaagataaagatgagaaagactcagcccttacctaaaggagtatagagcctagttggggagacaggaggcagatagttacagcatggagagcaaatt
ctctgagggaggaatgaagtgagataagagcacagaagaaagacccggggatcagagcagacttcctggaggaggcaatcattgacttg
1928 2627501 — NO tcctgcttgtgaacagattcctatttccgtgaggaggtgacctcgaagaagagcagcttctattctgctgggaggtgtactgccttctggtatcaggcttctgca
tcccgggaaagctcgggataacctgaggcacc
1929 3608077 — NO agaccacaatgagggacatggcaagttcct
1930 2393810 — NO ttgaggaaaattgctctgtccctat
1931 2506539 — NO tccatttaaatgagagggtggagctgtccttgcaaaccaatgatgcagctgatgccatgcagtggatcttccttccccctaaa
1932 3068053 — NO tttcccagagctctaccttgttgtcagcactccctgcaatag
1933 3762439 — NO ctaagagagttactgaccctaactcccctaaaacctaactatcaaaagcctaccactgactggaagccttacaataacactaacagttgg
1934 3896232 — NO tcagtctgcgatgaaggtgaacccatcttataaagcagagcttacttacattctgcaggattttggtgtggatgcatagaaggcttacctggttagtaagcctcc
attcctccgacctacagaaggcaacccttctgcagctccaagcagggatttctagaaaagaccaggtgtacaaaacatctaagctgtgcctcccaccacag
gtggggaagtcccctgatttggtcagacacagatgaatgtctgtgtctgactgagcccagaaacagttcaattgatgggggctggaaccaccaagaaaaca
ctcctgacctgggcaacactgtcttccagattat
1935 3916144 C21orf74 NO tgtgtgtacctgagataagatgatgtcttgtccaatgctggtttccaccttgtgccctgagctgttgggagaggctcctgcgacctgtgac
1936 2389578 — NO ggcttacgcagcagatgcacgttcagcattgagaacccggtccgacaggaaagacacaccatttttccgccagaaactccagtgttcaaaatacaaactgc
caacttttcaggcaataatcatgagcttccattagaaaaagccatcagctcaccagacgacgaaatatgctctcgggattaagaactttctcatcctccctgag
ccctttcctttcaggggaagtgcaagtttg
1937 3290995 ANK3 YES agcgggctaacaccactgcatgtagctgcacattacgataatcagaaagtggcccttctgcttttggaccaaggagcctcacctcacgcagccgcaaa
1938 3403153 EMG1 NO tgtcacatcctttgaccctggtctgagctgactgctggaagatgatctttctgcactgagactgtggagtttggggaagccaaggctgtacatttgctatttgttta
tcctatgaatactgttcttgcaaacctggttgttttggggttcctaaagtatccagtggtgtaaaactgtttgttccccgggacttcagggacagataggaggtta
cagagtttgcagtttggttccatgctttgaaggcaggctttagctcccagattcccatgtgctaaaggagagaaccctgatgatggagaagaactgtgaaaga
gagcagtcaggaatgctagtggtgaaaaactgaacaaacagaagtgattttatctaatacagttccaaggtagaaaaagtggagcaggcagggccttgcac
ccctctccacccccccatggggggggtggtggtagcggcacatacacaatc
1939 3439875 — NO acctggctttggttattgatgagaagagtaattaatagaacattccctttgctgtgataccctacccaaaatagctcggttgttggttcactttcttcagatacctcc
ttgtctcatggaccgcctacttact
1940 3568358 — NO tcatgggtttccaaatatgggatgcaatttcaagttcttaacaccaaatataaccctacttgttttagtttcctggcattcatcctatcatccccagtttactgcacctc
aggttatcaaggatgtgggagggattctacaagggtatgttcccccagagctttttggtaccctgcaatcccagaagttgttgatgctaggatgtctggagagc
actggccatttattactga
1941 3701322 CDYL2 YES tgacgtgaatcacgctacactggcggagaacgggctc
1942 2975832 — NO gccatgatcgtagcactatactctagcc
1943 3072788 — NO gtctaattcagaacccggtgggctctccatgcattattggcagcacttttatccaggggcacagacagggaatagggttactggaaacagggagtgtagctc
aaggaattgttctctctctggagtggataagttgtttgacctactgactcatttcataggaattaggaaaacaacctagtgtggtttttattgttagtcctggaggat
tccaaaatctgtgtgcctgcaaataagatgagctggggaaagggagcaccagcatttggtgtttctacttgcctcttttcctgatggaatccaatcctctgcttc
1944 3380982 — NO gctgtttcagtccacaccttgttcacagtaagatattcaattcaattcagcaaacatttgttgagtgcttgctgctctgtgcctgaccagaagaaatgaagccaag
atacaaataatagaaccctgtcatgagcacagaaagacctgctgagtttctattgattgtggtaaaccagcctgcatccagttccaagtaacagctgcccactt
agtgaatactctctcatgtttcaacactcagttctagtgtagcctcttctataaagcctttcttttccagataaaattggttaatgtgtcctgtgttaggctgattgatttt
gatgatccctattcatggtctcccctgtatccatctctttttgcctataacattgtagtcccatctcactctgatgctgggaccagacatgtgacttgttttagccaat
gagatgtcgataaacatgaagcaaacagaagctttaaaggaggcctgccctcttgctctttgccagtgccatgagaacatggctgatcagctggagggttat
gagatgtgtaggtgagagacatgcaaaagagccagagataccagctgaagccatcctagactagcccacagtcagcctacccccagtcaagatcaggag
agtcacccaacccacagatgactgccgacacatgagtaagcc
1945 3902033 — NO attccacgcgtcaaattgtgggcagtga
1946 3952107 — NO acaggcacaggggagtcaagcttag
1947 2678585 — NO agcacccagtctctgttctcagagg
1948 3463862 PPFIA2 YES tctcaggggatcacgagtggaatagaactcaacagattggagtactaagcagccacccttttgaaagtgacactgaaatgtctgatattgatgatgatgacag
agaaacaatttttagctcaatggatcttctctccaagtggtcattccgatgcccagacgcta
1949 3727958 — NO caccatcttctcggatggatggcaaag
1950 3974043 — NO agcaagccagtgcagtccttggtcacagtcactcacag
1951 3982214 — NO ccaaaaccaatgtgtctaaggtgcggcatcttg
1952 2685843 — NO gcggtggtccaatcatagttcactat
1953 2686522 ABI3BP NO ccagacatgccaccaactaaatccg
1954 4014220 POF1B NO cttcctctgtagctgccagacctgc
1955 2838069 TTC1 YES aatggccatcaatgactgcagcaaag
1956 3701416 — NO cgcatctggcctataccagtgtatgttttctttaggaaaaaataaggcagaaaccagaaaactaacacttcacataaatgtaggtgcagaatattggtacgatat
tggataacttaaattgctgaactgtatgaaacttaatttttctaaggcaaaaattgatatcattggaaggatcttggagtcagtggcaggcaaacaaaatttaaac
ttggctgcattttcttttttcgtttcaaatgaatacttaactaggtgcaatggctttatttgtggtcttc
1957 3756107 — NO tgaattcacagtgttgtatcccatgtagggaaaaataagactaattttccccccacactctaacacactgtaattttgcacttggaactttgctaatctactgtccaa
cctccttctcaacaaagtcaaatcaaaggagaattaacctagaagaggggacaataaaataagaggtcctcagggagagggagaaccaaggaaatagaa
tctacttaaatctggccagatagcacctcgtggatt
1958 2382147 CAPN2 YES atgacaggctgcccaccaaggacggggagctgctctttgtgcattcagccgaagggagcgagttct
1959 2590022 ZNF385B NO agagaaacacatcactagattgacgagggcttttagagactgctcctataattgaggaatcagcagcataggctttatctccctacttc
1960 3831701 — NO gtattggcgactgcctgtgcatacac
1961 2792492 — NO ctgactgtgaattagagtttgcgctattggaaggtggaacccactgtgctcattgtata
1962 3289301 — NO gcatttactagtgctgtgtgcctcgttgcttttctgggtagtgtttggtgatgggcatagtgtggagtggtggtagagtacacagtgtgattctgtctggtaagga
agctgtatgttgatgttcactgatgtgaataggttcatacagtcccttaggcatttggctggaggataaagaacagccattgaccagcagagtactttttttgaag
tttatgcaagacagcgtgctaggtactactgccagcttga
1963 3686344 XPO6 YES gtcctttctccagcccgacatccacctttttaaacaaaatctcttctacttggagactctcaacaccaagcaga
1964 2596800 — NO tgactaaaattttgggtctgggctgttatatcactttgtgttaagttatttgtagtagctaatgtgctaacttatatatgtgttctttctgattttttggattttaccttttgatttt
ggcataacttatctatatttttgtttacattattttaaaaatatcagtaactgtaataatataaaattgaagttgtattgagttgacaatacctctagtttttaaggtcatctgt
cacataatttaagtgcaccagttcctaatgtataaag
1965 2614940 — NO ctgctccattggagacttcctgagggcaacagacaaactatttgatagctgaat
1966 3988991 NDUFA1 YES tcattttgggtatcactggagtctgatggaaagagataggcgcatctctggagttgatcgttactatgtgtcaaag
1967 3068834 — NO tcatataatagacagtgcggttgcaccttgtgttcatgtactgatagctgttaagggtgcagtgatgaaccaacagagctc
1968 3116499 — NO gcctctctgttctcatgggctacatg
1969 3227229 FNBP1 YES ccaacctgaacgaaatgaatgattacgcagggcagcatgaagttatctccgagaacatggcatcacagatcattgtggacttggcacgctatgttcaggaa
1970 3777767 — NO tgtgtttggggtgattagagcttcttgcaagcttagaagtaggaagctaatg
1971 3950135 — NO cactggcacaggacgaccctgaagg
1972 3425446 — NO gcatgtcttgctactacttcatagatgtcataagacccgtttatggattagagttggtgtagaaagccattgccttgagttgaaaaatgaatactgtaaaagctca
atacaaatcctccaaagcacatgcactt
1973 2359042 — NO ccaagttctcatcttcagcatcgcagtttcgttctccacc
1974 2437704 GON4L NO ttccattctattactcttaggtttgtatctcatggaattcactttaacctctgcctcgtgttatttgctttagctgtacattatgctctta
1975 2778373 — NO cccaaaacatagatccgaacaccagctttgccc
1976 2954503 — NO atttcctacactgttgatggtggcaatgacaaaatcaattgcagtg
1977 2441001 — NO ctggagaaatggctatgggtgactg
1978 3162378 — NO gaattagttcctcagcccagtgtaagactggattaaaaatcgtgcatggatgtgcaggg
1979 3199012 MPDZ YES cacccagtcagtcagagtcagagccagagaaggctccattgtgcag
1980 3449682 — NO aagggtgtggcacattgctggtgttttcagggaagaaagcagaacgtctgtgggcaagcagtgg
1981 3687337 — NO ggagatccttgtgtagcggcagaaagtttagcaacactgtctcctgcattagtgtggagggtaggaaatatacctaaggaacggatggtctagctaaggagc
tttccagacagaatgttgaaggtgccacctggcttcttgctgcttatagtaaaactgaagaggagagagtaagttaaagaaaaaaaacacttaaatgaaaaag
agcctgaaattgttgggtttgaaaattcccagcctttccagataacaagtgatgttaaaattaacaaatggcttccgtgcaaagattaaatacaaggcattaaata
cagggaaatgtggtctaaaggtcaagctgaggatgtgatgaaaaagtcctttgttaagacctcagaaataccaacaagatgcctcagaggggacttccagtc
gaatgaaataataatcacgcttctgagaaggttaaaggtgttgtctttcagcgtctcagcacaagcccaaagtagagaagggcttaccttgcagagattttc
1982 2333554 ST3GAL3 YES cctacccttggcagtgtggcagtga
1983 2570354 — NO gtgttacttccaccatggtgccacacacttaatatccattcc
1984 2873144 — NO ggggcttctctatgcccggaaactgcctcatcaactgaaacaaatcctgaatcatcaaagggccaaacccactgccacctttagacggagcaggagagtta
ccctggctctgtcactgccactaagtcta
1985 3409485 — NO tgaataggcagctagtacatgaacctggcattaggggtttggggctggcatacttaaacatgtggctagatgtgatcaccttcagagtaaatgtaaatagtatc
atccctccttatctgtatc
1986 3476542 — NO gtgtgttccaggcgatggcaggaggga
1987 3620299 — NO atgacagtttttctctaggctaataactcaatgagcagaaaggaaagtcctcccttttaaatgtatatgaatgtatatgtagttcacacttacactctgacacagat
ctcattgtgtccaatgatgtgtgtgtgtgtgtgtgtgtgtgtgtctccaagactgagacacatgtactaaagagtgatactggccacatctactctgggcttggag
ggtaacttcagcaa
1988 3626913 — NO tgcaacctcgacctgcttggcttaagcaa
1989 2699759 — NO ccatcatgagctgaccaacaatttctaaattcctactcagaaacacagcaaggggaatgcagtcaagcacaaagggcttaaatgaccagataaggctgggc
tggatgaataaagaggaatatcctatgaatgtgactgtgtagttttagagtatcccgattcaactgttatatttgacttgtggccttgtagacagtgtgtta
1990 2737582 — NO tagccaagtgcagagggtgtctccgggtgtgtgcgtggcccacaagagggcaagaagagagaaggcggggataggagggaagagggtgggggtga
gaggcagccctgagagggcggaggaaggaagaggctgggagctcggcgcccgcggcgcagctgccgtcgctgccgcagctgtccagggaggatcg
ccaaaacggcgacgaataaacaacttaccttgcggagaagagctacgactgcgatgc
1991 2964449 MDN1 YES cccgatggaatatgcaggctctggacatgattagaaatttgatggactttgacccacaaacggaccagcctga
1992 3695220 DYNC1LI2 YES ggagctgccttgatttacacatcag
1993 2939888 LYRM4 YES taaagaatatctcctccaggtgtggt
1994 3632627 — NO atggagatctacactgacaccctcagtcctagaggcagagaagaggttcagatctggcctg
1995 3695228 DYNC1LI2 YES cacgcgctgcaacgtgtggattctggatggagacttgtaccacaaaggcctgctgaaatttgcagtttctgctgaatccttgccagagaccctcgtcatttttgt
tgcag
1996 3854016 — NO tagatctcgtcgctggtatgcttggttccgctcctcgtttcttagttgcttattctacccgttattcactgatgtta
1997 3980369 FAM155B NO tccatcacagacagcagagccgggcagctttcttatgccattttctacactgtgcttcatgagtaggactttcttgcactagttcctatgactgagtctccaaact
ggtttcctagtagtcccccatcccttcctcccttacccagctatgattcagttgtctctgccctccctcttaccctgcctctgtgtttcggtgagagtc
1998 3799919 — NO tgtattacacagagactaccgcacaaaacacggacccaatgccaggcaagcacgcgcccagcctgaacctccaagaactgtctt
1999 3032425 — NO cacacctgtaagctgaggtgaaggagtt
2000 2475245 PPP1CB YES aaagaaagctaaataccagtatggtggactgaattctggacgtcctgtcactccacctcgaacagctaatccgccgaagaaaa
2001 3487169 DGKH YES tctggggataccgaaagtgggtcatgtgaagcgaattctccag
2002 3955155 — NO aatgacatcccttttgagctgtggatggtg
2003 2827160 PHAX YES cacggcaactgcatgtgcaccagtatcacattatcgagctgttgaaagtgtggattcaagtgaagaaagtttttctgattcagatgatgatagctgtctttggaa
acgcaaacgacagaaatgttttaaccctcctcccaaaccagagccttttcagtttggccagagcagtcagaaaccacctgttgctggaggaaagaagattaa
caacatatggggtgctgtgctgcaggaacagaatcaagatgcagtggccactgaacttggtatcttgggaatggagggcactattgacagaagcagacaat
ccgagacctacaatta
2004 3186892 — NO atagataacgtttgtgtggcactccccaagactcaggcattgtgataactaacactttccatgaataatgtcatagaattctcacaaacatcctgtgagatagac
actattattttcaaccccatgtacatatgagaatactgagagttggagagactgagtaacatgccctagatgactcagctagcaaggaatgaaaagcacattct
aactccacccacatatatagttccaggatcccatctctctacctcacattaattagttctataccagctttatgtttcctactagaatgtgcatgttttaaaggctgag
ctttc
2005 3195536 — NO tggccttctggacagtaggtaggcatgtgatcactgttgtcactaaacctgggaaatgattcctgggtcagggttcattaattgc
2006 3238305 — NO gtattgaaattcctcgagccgctgcttttctcactccataattctggccagaatttggtacttaaaatattttgtctaaaatattacaatagctacttaagtcatctccc
tgactccactctgttgtctttcagggcgtcgtccacactgtagccaaagtgatcttataaaaacataattctaatcatggcactcttctgcttaaaaatgttttaatg
gctttccgttaggttaaaatttaaaagtcctttgtagcctgtgaga
2007 3744218 VAMP2 NO acttgctggaaaacggggatgcttgcccctctccaggactattgagcccagagagagctgtcctctcattgggtgaactgattgaggaagggtctattgtcttt
ttaaatggcacaattttaagggtttgagggtacagtcccttaacctgccacgggagggggcccccaaactttcttccccccacacttctggttttctgtgtggag
ggggagcagggatatctaagctgtggtgtgaaagggtaggagagatgctggaggtgggggtgctgtgttttagaccccccatattatcccagtgtcccctg
cccccctcttcccccaccccatgcccccaattctgtggcgcatccagattgtgaaaatgta
2008 3810033 — NO gtgaatatatctaggtccagcagggtctcagaagcagatgccaacctgaggggaatatttaccagatga
2009 3943786 — NO cagcagctgctatccatcgtcatcaccagtgtcatcatcgccatccccatcatcaccaccaacaccgccacccccccagcgacacactagctgtggacaca
tcctttacgcccttgaacctgagtttctacagctatgaagcaagtcccatggaatttacagaccaaacgctaagtgtagggctccctgggagctggtcttatgg
agcacactggca
2010 2321472 — NO cagtccatgaggtccacttgtctaaatatgtcacttgaagtgcaaggtaccaattgctcagtggctcaaaatgattttctggttctgttgtcatttcaagagcttctc
ttgagggttgagagagtctgttttcctaagaatctggttctctccatcagtctctgtttccaccttatcttcctgggaaggtgtgctttctttgaggtgagatgtgaa
gcctgcccacgtgcagttttatgtcgaattccaagtcagatcttaacttggtactcccggagcctgttggaagtctta
2011 2361272 — NO gtgcaacatcactttgacttgattattcttgggtctgttttatttcccgcttttattttgcttttgaaatctttttccttggtggatttgtacgtgtcttcactagatgcctca
aattaagtctgaccacaatcctactctactt
2012 2447714 — NO tgccaacttctcttcaccacacaatctgcagaagc
2013 3175671 VPS13A YES tatgatgatgcctatagatttgggggaaaagacaatatatttagtttcattctttgaaggtttacaacgcattattttattcactgaagatccaagggtatttaaagta
acatatgaaagtgagaaagcagagttagcagagcaagaaattgcagtggcattacaagatgttggaatttctcttgtcaacaattacacgaagcaagaagta
gcctatata
2014 3517776 — NO tataaggacttcacagatagctgccgtggatgctg
2015 3626941 — NO taatttcacaatgggtgtgggaggttggtgagtagatggactagattcaaaagtagatacctcgctctcacctatagcctagcagttt
2016 2467805 TTC15 NO ctccaacacactacgtcagaaggacccgg
2017 3701421 — NO ttgctttgtcttgtgatcgcagctcacggcagccttggactcgtgggcacgag
2018 3717066 NF1 YES cagaaagtgctgcaattgcctgtgtca
2019 2476534 — NO agatggtacaaaggtcgtgatagggctg
2020 2750682 — NO ccaagattaggccactgccctgtaac
2021 2412205 — NO gggttaagctgggaaccatgtctcctggggcaaaattttaattcttctagccacttgttatgtgatctcaagcaaggtacatacgtctctgggtctttttttctttatct
aaaatatgaagagattaagtgttttcttaattttctttcagctctgatattatgtgattctgtgattaaatgacctggatgttgataatacatgcc
2022 3019902 — NO ctttggagttttcgcccagatcagaattttattgccttttgccgtagactgctgcaagatttccagagcaaagagaaggtatagtgttccttaatgtgagttatgaa
gatcaaaatacagcaaagagaagatttcagagatttaaaagtgataatttttactgaaatttggaaatatgtctccatattttaactttattttataaaaaagaattact
ctgttttttgaaatggccaagcattaagtaatatatgaccgtgaatttcttgagggtgggaaatgtgactggattttatatttcgattgtatcacatgcagcctc
2023 3750928 KIAA0100 YES acactatgtggcattgtgctttggagaagtgcgtatcagaacggacctacagaaagtttctgacctgtctgccccattc
2024 2511032 — NO atgactgagtcttatagcggtgttgggcatagca
2025 2568632 — NO atcctttgtcccgattgggtcccagatacacaaaa
2026 3039827 — NO gagtccttcctggatagcagcaccaaag
2027 2437284 C1orf2 YES cagctgccaccggttggagggctgg
2028 3076362 — NO gcatacaagtctgcccagtcccaggaagaaagaggagagaccctgaattctgaccttttgatggtcaggcatgatggaaagaaactgctgctacagcttgg
gagatttgctatggaaagtctgccagtcaactttgcccttctaaccaccagatcaatttgtggctgatcatctgatggggcagtttcaatcaccaagcatcgttct
ctttcctgttctggaattttgttttggagctctttcccctagtgaccaccagttagtttctgagggatggaacaaaaatgcagcttgccctttctatgtggtgcgtgtt
caggccttgacagattttatcaaaaggaaactattttatttaaatggaggctgagtggtgagtagatgtgtcttggtatggaggaaaagggcatgctgcatcttc
ttcctgacctccggggtctctggccttttgtttccttgctcactgaggggtctgtctaaccaagcaggcta
2029 3527927 FLJ10357 NO tgagtcagcatccccaatttctaccacatccagcactcctaccatcttgcatgtaccttccttcctgtccccggctacttgggagtcagcttcttccctctcccaac
tcatctccctcttct
2030 3889598 — NO caggtcttagcggtcatcaggatgaaggcggtgggaagtggagcaacagagatccaaatatggaaagagcacgtgctgataccagaggcactggaaata
atagcaatatccgaaagtctgctcaccctgcgtcattccttcagacagtagtcgggctctattc
2031 3735624 MFSD11 NO ttaaaatctgcaatactggccaatattcttttatcaaacaggagaccgcagctttaaagggggaaaatgcagacgttggataaaaacagcaagaaatagtcat
tttcattaataggtctcaaacagtttacgaaacagccattattatc
2032 2739508 — NO ggcatgtgtgggtaattagttctcactatggttagactcctgaagtgagtggtccaagttgttagcgtgcttctgctctgtgaggccaggccagtatcctgtctg
2033 3819517 RAB11B YES gacatcgccaagcacctgacctatgagaacgtggagcgctggctgaaggagctgcgggaccacgcagacagcaacatc
2034 3330082 PTPRJ NO ggggtcagctatgcagcccatcacgtgtgtttttcatctgggatgaaaaagcctggttctcttttgaaatgcttgattgtacttattgagctaaacaagtcttggtg
actgttgttgatttgcctcaaaagttttaagtcctgggttttcagactactgtgta
2035 3378442 SPTBN2 NO ggccacattctcctaatagcatgaaacagtcagctcactttctgcctcctcctcttacacttccctgctgtccactgcggccaactcagcacagtgtccttgaag
ctgattgagggtc
2036 2473789 — NO gcgcgggctttcgagcacatacaaacctgattacaaaagtcagatttctttatttcgtcttgggcacgtcattttaaccccgctcagcctctcttttgtgtatgaaa
ctgaaagtaatagcttctgctgtgcaaaatgattagaggaatttgtgaagcgcttggcaacatactaggaccc
2037 3115627 — NO ttgagatttatgtgtgtgccagacacacacacacacacatatgtacacaagcaatttttgtgtgtgtggctcaagccaggcagagaaagacaaatactaaatg
atctcactcatatgtgaaatctaaaaaagttgatctcaaagaagtagaaaggagcctggtggttatcagagtctggggagggggttggggagatattggcca
aaggatatacaatttcagttaggtaggaggaataagttcaagaagtcgattttgactatagttaataatgtgttgtattcatgaacaaggctaagagagtggatgt
aaagtgttcttaccacaaaaaggataactacatgaggtaatgcacatgttaattagctagatttagtaattccataatgtatccactg
2038 2745189 — NO tccatttctttttactgcgtccgtccctgacaatacctgctgtttactcagcccttaacgttg
2039 3450260 — NO aaagtgatacatttgtgagggaggagg
2040 2656876 — NO cagaccttatctcatagggtgattatgagcattagatgaaatcgtgggtgaaaggctcagtacagtgccaggtatacaagaagcattcagttaagtaatagct
gttattgttataactgaggttttcacaagccgcacact
2041 2952697 — NO gctagtttcaaagactgcgaccctgttttgaattggcttgtttatgttgcgacggtggctggaagccaggccaacccagggtcagctttcccaaatcagtcgcc
aaggcccacgagaacagtagtttcagaactcccagaaataggttcaaagatgcctgtcctgtaccagtcctgcccagcctcgtttttccttaccaccctgactg
cagtcttaactcctgcaaactaatttgatcgctctaagtttaaccgcgcccagaatttcacttttgcttgcttggcctttgctgtgggtcacaacagcccttcttgc
2042 3579549 WARS YES cctggcctctgtaagcctgtgtatgttatcaatactgtttcttcctgtgagttccattatttctatctcttatgggcaaagcattgtgggtaattggtgctggctaacat
tgcatggtcggatagagaagtccagctgtgagtctctccccaaagcagccccacagtggagcctttggctggaagtccatgggccaccctgttcttgtccat
ggaggactccgagggttccaagtatactcttaagacccactctgtttaaaaatatatattctatgtatgcgtatatggaattgaaatgtcattattgtaacctagaa
agtgctttgaaatattgatgtggggaggtttattgagcacaagatgtatttcagcccatgccccctcccaaaaagaaattgataagtaaaagcttcgttatacatt
tgactaagaaatcacccagctttaaagctgcttttaacaatgaagattgaacagagttcagcaattttgattaaattaagacttgggggtgaaactttccagtttac
tgaactccagaccatgcatgtagtccactccagaaatcatgctcgcttcccttggcacaccagtgttctcctgccaaatgaccctagaccctctgtcctgcaga
gtcagggtggcttttcccctgactgtgtccgatgccaaggagtcctggcctccgcagatgcttcattttgacccttggctgcagtggaagtcagcacagagca
gtgccctggctgtgtccctggacgggtggacttagctagggagaaagtcgaggcagcagccctcgaggccctcacagatgtctaggcaggcctca
2043 3703035 — NO cgatggacactgatgcccacacaggtg
2044 2444562 RC3H1 NO tccagatggatcgttggcctaaattttcacacttctccctgttcatcctttttcctcttccctgcttcctgggaataaaaggaacttttttaaaaaaattaattagtcc
acaggtctcattatctttctttatgattaatctatgactttttggtacaagaacaatggaaaaagtgaattaaggtaatgaacaaaacctttcacccacttaaacattt
tccagttttgagattcctcttcgtgtttgtggtgtcttccccttgttaccccttctgccctttttctctgactatggtaatttggtctttaggctcatatcagtctccccga
gacattctgcagtcattatcacctttttgggtggattttattttgttttattttgttttttttaaaaaaataactttttaacattggtgcatatttgcttgggatagagcttgtg
taatttaccaatcgtattgattgtaagtgattgtgccctgcagaggtatatttaacaagacaaaaataatcttggttaataaaggagcccatgagatttgagtcag
gttgtaagtgaaatcacttacacttttggatagaatttatactcctgctcttataaatcagtggtagacttaccattttttaaagttttcttgcatttttttgtttttttattgc
cacagctccctattctttcttgcctgcctccacccccctgttcaggaaaaaaaaaaattgagccttaaagtgacagctgattttttaattgctgaattttgtgaaattt
tactttttccaagtgtttccaactttaaaaagagaagtgaagacaaataggttggaatggtgaagacaaatggattggaatttcacaggctgtgaataattcctta
ggatctggcaaaccgtgaagtcttatttgaagaccttatctcctgagagttcttttggagtaggaaaaagaaccctatttgaaatagaccgtttttctcttgtttttaa
tctgtttaatatttctgatttttaagcagcttt
2045 3816284 DOT1L YES ccaggtcgtgctccaggttgctgctgccaccaactgcaaacatcactatggcgtcgagaaagcagacatcccggccaagtatgcgga
2046 3231694 — NO atccaccaagcagtgcgtccaggtg
2047 3760111 — NO gaatgaacgcagagagtgtcagtgctgaca
2048 3960937 — NO caggcacaccgccttgaggtgggcagtgccc
2049 2519659 COL3A1 NO gaaagattcattggcatgccacaggggattctcctcc
2050 3380965 — NO tctaacccttgagacactgccaacatccctcctagtacaagacttttcttggtgcttgctgtttttagaggagttttggcccttcagtgtttgtaaagctctcggatc
ctcagaaaaaaattctttagtgattaattttgaaattggagctgtttgattattttgattaagaagctgattttcggcctggcacg
2051 3690096 DNAJA2 YES agatgggaatgatttgcacatgacatataaaataggacttgttgaagctctatgtggatttcagttcacatttaagcaccttgatggacgtcagattgtggtgaaa
taccc
2052 3777917 — YES aggatcctgccgaaaggtgctcagtggcct
2053 3811929 — NO atgtatcattctccatacacctgtgcctt
2054 2436400 — NO ccagccacgcgtccagcaggtcagggatt
2055 3868616 SHANK1 YES tacatcattaaggagaagacagtcttgctgcagaagaaggacagtgaggggtttgg
2056 2833315 — NO atcttttgattgctagcccagctgctttccttgttatcactttgtggagcaggctggacattgacaatgagttctgagactgagtggaatgggagacccctccca
gctggtggtcgagctgcctagagcatggtccatctgtttgggactagggttgagctcc
2057 2886091 — NO tgacgaatttcgtctttcttccctacggtggagtcagtgttaaacatacaacaaggagttctggggcacaggc
2058 3146585 RNF19A YES atgtccacgatgtgctgcttatataataaagatgaatgatgggagctgcaatcacatgacatgtgc
2059 3271059 — NO gtgagatacttgacatggggacctttac
2060 3589673 — NO ttcaagaagttctggggacagaggg
2061 3971336 MBTPS2 YES tccttggaaaaacgctgatgcagactttggcacaaatgatggctgactctccctcttcttattcttcctcctcttcttcctcttcctcctcttcttcctcttcctcttcttc
atcttcttcctcttcctcgcttcacaatgaacaggtgttacaagttgtg
2062 3304025 — NO gtatgtgataagtatttggatttgagagtagacctttcatagtgaggcttatcaggttgaggggaggtgatgactggaaatatatttatttattttaaatcccactttg
gctttagtaaaatctgaatatgtgtgcatttctagtttcttacaccaaatgtaggttccgtaagttcatgcaagtacagtgggtc
2063 3350758 PAFAH1B2 YES agacaaagagcctgatgtactgttcgtgggagactccatggtgcagttaatgcagcaat
2064 3921733 — NO cagtgtcgctacaggggatctctcaggctcacaacgggccactcctctagggaagttctggtctcatcatgatccttgtttggtctcactccccatgtccttctct
gtccctcctccaactgccatttatttatttaactgaaaaagtaccaatcacccacataggcatga
2065 2361637 — NO acaggagccaatgcccaatcatagc
2066 2625412 — NO accacctgggtattgaagccctataaaaacactttctacttaccttaatatagtctggcgttgctgggacctcacagtgttctttcacactttttatgtaacttagga
actgaaataccactcatgcatttgttctaaag
2067 2737704 — NO gattgctatggaagtactgagtccctgaaggagagacaaggtgcaggaagccccaatcgccaggccatcgatgaaattgtggagggcatcgcagagcgt
tatcatccaggcaatcgtccctatt
2068 2795252 — NO gttcggatgatttcacgggagcagc
2069 3203541 AQP7 YES gctgtgacctttgctaactgtgcgctgggccgcg
2070 3510917 — NO aagaccagggtaatcatagaactgccaagcagaaagaaatgtagaatgtagcagtggtgtggagacccgtggctgacaggtggtggtcttcatataggct
gagggacaggctagatgcatgtcaagtggc
2071 3670551 — NO gagctccagggatatctcttctgcacattcttccagagcagtgcatctctcttctggttgtttgtacacccttcttttactctccttattatcctctcccatgttcattca
gtacatacttagtgagtgttcaccagatgcttagcacctggggtatac
2072 3729159 DHX40 NO gcctatggcaggattctttcttgaattaatattaatccttaaattgatttttctgggattatacaaattcctttttatataaaagtatattgtttaaaacagtagctatagc
cattaaccaaaggacagatgatatatatatatatgatatatatatatatataagttcttttttagctgtacctacgtacttatatcagcaccatgtatgtaggtgtgata
gtactttcaaacagcgcctccacctggcctactctgttatttccacctgtttgggtagggccatttaacttccattatgccaaacttgggatgggattttcgaagca
gacaacactatttcatcgtgtttcaaattggaaccttgaggctagttagtatcacact
2073 2969482 CDC2L6 YES tgtatttgccggctgccagattccataccccaaacgagaattccttaatgaagat
2074 3040116 SNX13 YES tggcaaccttattttactacacgcattgtagatgactttggcacacacttacgagtattcagaaaggctcaaca
2075 3819122 LOC100129391 YES gaggtggctagaaaacggcaagaac
2076 2359763 — NO acctgcgtcacaccctggctagtgacccagtcagacgtgctggggaccctggctgaccacctgtaccaggggcaaggaaggaaggagaggggagcatt
gtgaagcagggcaggatgactcttgaaggtggagacaggccctggacagctctgggacccttaatggtggcagc
2077 2969302 WASF1 YES ggtttgatagaaaatcgccctcagtcaccagctacaggcagaacacctgtgtttgt
2078 2330410 C1orf113 NO gaagctggtcccacggaaagtggtatctcgggaatcag
2079 3265461 FAM160B1 NO tctaggtggggaactgactgataacccttggcagcaatcaaagtgccagtggctcctcgatgtttacatttttttctattttgttcagtcttttgttttaaatgattcta
aagagattaaagaaaacagagttttaaatgtcctatttacatgttaaaggatttggggaaattgggtatgtatgtgaatgggtgtacatgtaggaacctgtagttc
agcaaagctgcgctgggcacagcatgcttgtacttgattgacaaaatcgtgtttgccagtccactttctatttttcctttaagtgatgctgatcactcaaataatgct
tttaagctattgtttgtttttatttgacatgttaagccgcagcactttcttcttcatctttccatttactgatatttgggggaacaggctatcaaaggttccggcttgaag
ggaactgtcactac
2080 3735093 LOC643008 NO gccaccgacttcgtgcaggagatgcgc
2081 2402500 PAFAH2 YES ggcaacattgacatgagccgtgtggctgtgatgggacattcatttggaggggccacagctatt
2082 3552152 MEG3 YES tcttcaacccactgcttcctgactcgctctactccgtggaagcacgctcaca
2083 2736402 — NO attataaggtatgatatggcttcccaattgtcaaagaattaaaatgctcattaggagaggagtgactgcttctccctttagtagaaaaacaattcaaactcaggtt
accaattacaatacacaaactaaaacagttatgttgagccgggaaaccgtcttcttgtaggctatcttctagcaccaaataatgcccacatgatttctggctgaa
ggcca
2084 2751960 — NO gcttccttcgtgaattctaaccgtaccgttactgtgtttgaggatcactggcagccgagctctgagtggggaactgagataagaaaggtgttgtcatgataaca
cctggacagctgcatcccacagactatgggagtgccaggaaactggctacctcacagcagagtagagaaaatggaaataaacacaaatataagcttttcag
tgagctgtgggtcagagaaggccacaagtggtctggcagatcatggtgcagctctttgtttcatgagctacgtgcagcagtagtttttatgagctctttttgtag
ctttccagccctaggattcagccatggtaa
2085 3024231 — NO tgcccagaaacgaccattttggacaatctcatccagttttacgcttgttttattcagaaagagaatcacctatcctcttcacatc
2086 2928814 — NO taaggaaattgggttgtcaccactggctttgagtaattcgttttgtctatgcaagctgtcttcatacgaaaaaggttttcatactatatccagtccc
2087 3166955 NFX1 YES gttgaagtcgaaacatcccactggacat
2088 3829651 KIAA0355 YES cctgactgtggtgcaagtccatttccagtttttgactcatgcgttacagaaggtccagccggtggctcactcttgctttgctgaggtcatcgtgcc
2089 3709186 JMJD3 YES gtcaggcagctgtaagcggcgacagaag
2090 2947628 — NO ctgttgacttcagagtcgagtgtgag
2091 3820638 SLC44A2 NO cccagtgatggccacgtcttgtttctagaatcccttcctttgcacaagccatattctgaactcttaattccttcccttaacttcaatccctatgtctcctgtcctacctc
atggttttcctggccccacacctgatgctcagagcccactgtgaacccctggtgcctcttttggactcggttc
2092 3823661 AP1M1 NO cagcctcagactttttcccactgagggtccagagagcggggccacgtgtcacccacgtctgcgcttggtcacccgtcctccccaccctgtgtgtgtttatgtc
atagttacattaa
2093 4038647 — NO aggtctccgctttcctggaaatccagaccc
2094 2543897 — NO agctctgggtgagacttgtcttccgggggctg
2095 2353902 — NO ctctgattaggtcttgtgcccattgttgaaccaaatgctgtgcttaggaggatgggacatgttctttttgttttgcttagttagggcctggctctggagccaggaga
ggggaggaggaaatgttgctggatgtaagttagcactgatactaattattctaacaatgattaatagttagaatggctgggtgcagtggcacatagtcccagct
ccgcaggaggttgagatgggaggatcgcctggggccaggagtccaaggctatggggcaccatgatcatga
2096 3190953 PPP2R4 YES cactttgtggatgagaaggccgtgaatgagaaccacaaggact
2097 3922999 PKNOX1 YES gcgcccggccgagaatgacatcttaa
2098 3701615 — NO atggacagcttcaaagggcagtttgggggtttctgtttattttcctgtatgttctggtcacctcaatcatctaaccagaagaactggcccaaaattaggcacaag
aaaaaaggaaaaagtctagccctgccacataactcctggaactggttgcagaaactgaac
2099 2528729 — NO gggaagacacgaagggagggcgctg
2100 3188305 — NO ggatagcttctattgtggacgtggaatcc
2101 3578798 — NO agatctactcctggatgcgggtacaggacagcatccccagactgtttgtaaagtctcatgtgatacatggagggcaggcct
2102 3810041 — NO agcagaagcaaacgggggtgtctcaggagggggccccgtttccttcttgtaaagctgctcccacccacagccacactccattcagtcaggtttatgtgctgtt
cttccttgtcccttatgaggtagaaccatcaccttgcgtgcaaagcagctta
2103 2520084 MGC13057 NO ggtgtctgtcggtctttgcttgtcagctgt
2104 2615285 — NO gtgtttgtgctcaatgtaagagcaaggaaggtgcgggaagatgagggggatgaggcgcaggagtacagggctgttattca
2105 2676383 NEK4 YES tggtagagtggtttgtacagatcgccatggctttgcag
2106 3337536 — NO aggcttcttgcacaggcagaaggggct
2107 3670582 — NO tacgtgcccaagaatcaatccaatccaactgataacattttctctgaagatagctgcctcttcaaatactggtacagagattcaagaagctgtaccacagacca
tcagtt
2108 2359853 — NO cccatttttcattaggtccaggtgtatccaaatgttgcca
2109 3349998 — NO tgatgtggccccgattgcagaattgagttggaggctgaagcatgtgagctctgatccttgcc
2110 3431977 — NO cttccctctggaagactaacatgtactgctgaagtcttgttcagtgtccttctagccccagactttgcagcctaccaacatggactgagacagggaaagcgtg
ggcaagtgagttccatactctaattttcctacagaagcatcctaagtggtgtgtgggttctcagatcaagtcacaaacacattcacagcccatgatatcgtacaa
cactactttttagttcaaattaattatgagtaacaacagactatctgccaaaatagggagctgca
2111 2482372 ACYP2 YES agctaggaaaataggagtggttggctg
2112 2619332 SS18L2 YES cattgcagatgccagtccaaccagcac
2113 3810037 — NO cccgtggctctaaaagtattatccgaaatcaaccagtcacccctttcaccttctctcagtttaaaaatggatccagtgcatacccaatag
2114 2944959 — NO gtaggaatcaaacatagcgccatctatctgctttttatattatcctacactattttaaaaactgctcaacagtcttatacagaaatctttaaaagatagacaggataa
catgctatattaaccccaccattgaaataatccaacaccatcacgattccgattaagagaagaaaaaaatcttttttttttctttttttttctttttttctttttttttttccga
aaccactcgccctccactgactgcccctgtaccacatcaaacagtctcctctcctccacgcctccggggtctgggaagtctcacctcactgatttc
TABLE 4
Differentially expressed RNA transcripts used to plot hierarchical
clustering and expression matrix (‘heat map’) in FIG. 1B. The 526
RNA transcripts represent a subset of the differentially expressed
transcripts (Table 3) between patients in the three clinical status
groups (i.e., ‘SYS’, ‘PSA’ and ‘NED’) disease using linear
regression and a p-value cut-off of p < 0.01. Weighting factors were
from the regression coeffecient values; positive and negative values
indicated transcripts correlated to increased expression in ‘SYS’
and ‘NED’ disease, respectively with intermediate expression
values in the ‘PSA’ disease group. Weighting factors were used
to derive 526-metagene values in FIG. 2.
SEQ
ID
No Weights
1 −6.08
2 −5.71
3 −5.68
4 −5.39
5 −5.26
6 −4.84
7 −4.7
8 −4.68
9 −4.66
10 −4.55
11 −4.53
12 −4.47
13 −4.4
14 −4.37
15 −4.32
16 −4.27
17 −4.23
18 −4.2
19 −4.18
20 −4.1
21 −4.09
22 −4.06
23 −4.03
24 −4.02
25 −4.01
26 −4
27 −3.96
28 −3.95
29 −3.95
30 −3.95
31 −3.95
32 −3.92
33 −3.91
34 −3.88
35 −3.86
36 −3.85
37 −3.8
38 −3.8
39 −3.79
40 −3.74
41 −3.73
42 −3.73
43 −3.71
44 −3.7
45 −3.7
46 −3.7
47 −3.68
48 −3.67
49 −3.66
50 −3.66
51 −3.65
52 −3.65
53 −3.64
54 −3.64
55 −3.63
56 −3.62
57 −3.6
58 −3.6
59 −3.59
60 −3.58
61 −3.58
62 −3.58
63 −3.58
64 −3.58
65 −3.57
66 −3.57
67 −3.57
68 −3.55
69 −3.52
70 −3.51
71 −3.5
72 −3.5
73 −3.49
74 −3.48
75 −3.48
76 −3.47
77 −3.47
78 −3.47
79 −3.47
80 −3.46
81 −3.45
82 −3.45
83 −3.44
84 −3.43
85 −3.43
86 −3.43
87 −3.43
88 −3.42
89 −3.41
90 −3.41
91 −3.4
92 −3.4
93 −3.39
94 −3.38
95 −3.36
96 −3.36
97 −3.36
98 −3.36
99 −3.35
100 −3.35
101 −3.35
102 −3.34
103 −3.34
104 −3.34
105 −3.33
106 −3.33
107 −3.32
108 −3.32
109 −3.31
110 −3.31
111 −3.3
112 −3.3
113 −3.3
114 −3.3
115 −3.27
116 −3.27
117 −3.26
118 −3.26
119 −3.26
120 −3.25
121 −3.25
122 −3.24
123 −3.24
124 −3.23
125 −3.23
126 −3.22
127 −3.22
128 −3.22
129 −3.22
130 −3.22
131 −3.21
132 −3.21
133 −3.21
134 −3.2
135 −3.19
136 −3.19
137 −3.19
138 −3.19
139 −3.18
140 −3.17
141 −3.17
142 −3.16
143 −3.16
144 −3.15
145 −3.14
146 −3.14
147 −3.13
148 −3.13
149 −3.12
150 −3.12
151 −3.11
152 −3.11
153 −3.11
154 −3.11
155 −3.1
156 −3.1
157 −3.09
158 −3.09
159 −3.09
160 −3.08
161 −3.08
162 −3.08
163 −3.07
164 −3.07
165 −3.07
166 −3.07
167 −3.07
168 −3.07
169 −3.06
170 −3.06
171 −3.06
172 −3.05
173 −3.05
174 −3.05
175 −3.05
176 −3.04
177 −3.03
178 −3.03
179 −3.03
180 −3.02
181 −3.02
182 −3.02
183 −3.01
184 −3.01
185 −3
186 −3
187 −2.96
188 −2.96
189 −2.96
190 −2.95
191 −2.95
192 −2.95
193 −2.94
194 −2.94
195 −2.94
196 −2.93
197 −2.92
198 −2.92
199 −2.92
200 −2.92
201 −2.91
202 −2.91
203 −2.9
204 −2.89
205 −2.89
206 −2.88
207 −2.88
208 −2.87
209 −2.87
210 −2.87
211 −2.86
212 −2.85
213 −2.85
914 5.32
915 5.27
916 4.82
917 4.64
918 4.59
919 4.54
920 4.49
921 4.45
922 4.43
923 4.38
924 4.38
925 4.36
926 4.36
927 4.33
928 4.27
929 4.27
930 4.18
931 4.17
932 4.13
933 4.12
934 4.08
935 4.08
936 4.07
937 4.07
938 4.04
939 4.03
940 4.03
941 4.02
942 4.02
943 4.01
944 3.97
945 3.95
946 3.95
947 3.95
948 3.95
949 3.92
950 3.92
951 3.9
952 3.89
953 3.88
954 3.84
955 3.84
956 3.83
957 3.8
958 3.8
959 3.8
960 3.79
961 3.77
962 3.76
963 3.75
964 3.74
965 3.72
966 3.71
967 3.71
968 3.71
969 3.7
970 3.7
971 3.69
972 3.69
973 3.68
974 3.67
975 3.66
976 3.65
977 3.64
978 3.63
979 3.62
980 3.62
981 3.61
982 3.61
983 3.6
984 3.6
985 3.59
986 3.59
987 3.58
988 3.58
989 3.57
990 3.57
991 3.56
992 3.56
993 3.55
994 3.55
995 3.55
996 3.55
997 3.54
998 3.54
999 3.54
1000 3.54
1001 3.54
1002 3.53
1003 3.53
1004 3.53
1005 3.53
1006 3.53
1007 3.53
1008 3.52
1009 3.52
1010 3.51
1011 3.51
1012 3.5
1013 3.49
1014 3.49
1015 3.48
1016 3.48
1017 3.48
1018 3.48
1019 3.47
1020 3.46
1021 3.45
1022 3.45
1023 3.44
1024 3.44
1025 3.44
1026 3.43
1027 3.43
1028 3.42
1029 3.41
1030 3.41
1031 3.41
1032 3.41
1033 3.4
1034 3.4
1035 3.4
1036 3.39
1037 3.39
1038 3.39
1039 3.39
1040 3.38
1041 3.38
1042 3.38
1043 3.38
1044 3.37
1045 3.37
1046 3.37
1047 3.36
1048 3.35
1049 3.35
1050 3.35
1051 3.34
1052 3.34
1053 3.33
1054 3.33
1055 3.33
1056 3.32
1057 3.31
1058 3.31
1059 3.31
1060 3.31
1061 3.3
1062 3.3
1063 3.3
1064 3.29
1065 3.29
1066 3.29
1067 3.28
1068 3.27
1069 3.27
1070 3.27
1071 3.27
1072 3.26
1073 3.26
1074 3.25
1075 3.24
1076 3.24
1077 3.24
1078 3.22
1079 3.22
1080 3.22
1081 3.21
1082 3.21
1083 3.2
1084 3.2
1085 3.2
1086 3.2
1087 3.2
1088 3.19
1089 3.19
1090 3.19
1091 3.19
1092 3.19
1093 3.18
1094 3.18
1095 3.18
1096 3.18
1097 3.18
1098 3.17
1099 3.17
1100 3.17
1101 3.16
1102 3.16
1103 3.16
1104 3.16
1105 3.15
1106 3.15
1107 3.15
1108 3.15
1109 3.14
1110 3.14
1111 3.14
1112 3.14
1113 3.13
1114 3.13
1115 3.12
1116 3.12
1117 3.12
1118 3.11
1119 3.11
1120 3.11
1121 3.11
1122 3.1
1123 3.1
1124 3.1
1125 3.09
1126 3.09
1127 3.09
1128 3.09
1129 3.09
1130 3.08
1131 3.08
1132 3.08
1133 3.08
1134 3.08
1135 3.07
1136 3.07
1137 3.07
1138 3.06
1139 3.06
1140 3.06
1141 3.06
1142 3.05
1143 3.05
1144 3.05
1145 3.05
1146 3.05
1147 3.04
1148 3.04
1149 3.04
1150 3.04
1151 3.04
1152 3.03
1153 3.03
1154 3.03
1155 3.03
1156 3.02
1157 3.02
1158 3.02
1159 3.01
1160 3.01
1161 3.01
1162 3.01
1163 3.01
1164 3.01
1165 3
1166 3
1167 3
1168 3
1169 3
1170 2.99
1171 2.99
1172 2.99
1173 2.99
1174 2.99
1175 2.99
1176 2.99
1177 2.98
1178 2.98
1179 2.97
1180 2.97
1181 2.97
1182 2.97
1183 2.96
1184 2.96
1185 2.96
1186 2.96
1187 2.96
1188 2.96
1189 2.95
1190 2.94
1191 2.94
1192 2.94
1193 2.94
1194 2.93
1195 2.93
1196 2.93
1197 2.93
1198 2.93
1199 2.92
1200 2.92
1201 2.91
1202 2.91
1203 2.91
1204 2.91
1205 2.9
1206 2.89
1207 2.89
1208 2.89
1209 2.89
1210 2.88
1211 2.88
1212 2.88
1213 2.87
1214 2.86
1215 2.86
1216 2.86
1217 2.86
1218 2.86
1219 2.85
1220 2.85
1221 2.85
1222 2.85
1223 2.85
1224 2.85
1225 2.85
1226 2.85
TABLE 5
Differentially expressed RNA transcripts used to plot
hierarchical clustering and expression matrix (‘heat map’)
in FIG. 1C. The 148 RNA transcripts represent a subset of the
most differentially expressed transcripts between patients with
clinically significant ‘recurrent’ (i.e., ‘SYS’) and ‘non-recurrent’
(i.e., ‘PSA’ and ‘NED’) disease. Weighting factors were
from the test statistic values; positive and negative values
indicated transcripts correlated to increased expression in
recurrent and non-recurrent disease, respectively. Weighting
factors were used to derive 148-metagene values, which were
converted by scaling and normalizing into ‘POP’ scores
depicted in FIG. 7.
SEQ ID No Weights
1 −4.1
2 −4.21
3 −5.48
4 −3.04
6 −3.73
8 −3.88
14 −3.78
20 −3.14
32 −3.87
33 −3.75
36 −4.93
42 −3.46
45 −3.1
46 −4.14
60 −5.72
63 −4.79
65 −3.82
66 −4.02
67 −3.37
69 −3.25
79 −3.1
86 −3.57
88 −4.54
96 −3.68
100 −3.63
104 −2.93
115 −3.29
129 −3.91
130 −3.32
181 −3.27
182 −3.37
187 −3.56
189 −3.44
194 −2.09
217 −4
225 −4.01
241 −4.16
265 −3.86
280 −4.02
293 −3.36
295 −3.57
334 −3.36
355 −3.44
387 −3.73
400 −3.17
437 −4.02
445 −3.14
460 −3.36
468 −3
536 −3.65
592 −2.7
596 −2.79
684 −2.75
915 3.78
920 4.36
923 3.23
925 3.04
926 4.61
927 3.79
933 3.24
934 3.65
935 3.64
939 4.2
941 4.14
944 3.72
945 4.03
947 4.44
949 3.77
954 4.34
960 3.54
968 3.84
970 3.5
971 4.68
974 3.63
978 5.27
986 2.59
999 4.74
1004 4.5
1005 3.62
1014 4.86
1022 6.29
1023 4.08
1031 3.75
1032 3.49
1039 3.44
1045 3.41
1052 3.28
1060 4.48
1062 4.1
1080 3.97
1093 4.02
1095 3.77
1101 3.55
1108 3.39
1117 3.97
1123 4.03
1124 3.45
1126 3.25
1132 3.51
1146 3.78
1147 3.37
1153 3.71
1164 3.54
1167 3.6
1194 3.2
1208 3.35
1218 3.56
1219 2.96
1233 3.44
1234 3.86
1248 3.56
1261 3.19
1291 2.99
1299 3.74
1300 3.33
1304 3.14
1311 3.66
1314 3.95
1318 3.9
1320 3.45
1324 3.31
1330 3.02
1335 4.35
1341 3.7
1344 2.93
1346 3.51
1357 3.82
1367 3.35
1369 3.75
1372 3.07
1375 3.17
1383 3.67
1390 3.49
1395 3.19
1402 3.45
1416 3.29
1425 3.73
1443 2.97
1453 3.01
1469 3.02
1474 3.52
1489 3.66
1503 3.19
1527 3.25
1551 3.41
1598 3.26
1624 2.91
1689 2.82
TABLE 6
Genes identified in a literature search as being correlated to
clinical outcome or prognosis in prostate cancer patients.
Indicated are the gene name and HNGC gene symbol.
Gene Name Symbol
Aminoadipate-semialdehyde dehydrogenase AASDH
ATP-binding cassette, sub-family A (ABC1), member 5 ABCA5
ATP-binding cassette, sub-family B (MDR/TAP), member 1 ABCB1
ATP-binding cassette, sub-family C (CFTR/MRP), member 2 ABCC2
ATP-binding cassette, sub-family C (CFTR/MRP), member 4 ABCC4
ATP-binding cassette, sub-family C (CFTR/MRP), member 5 ABCC5
ATP-binding cassette, sub-family G (WHITE), member 2 ABCG2
V-abl Abelson murine leukemia viral oncogene homolog 1 ABL1
Acetyl-Coenzyme A carboxylase alpha ACACA
Acyl-Coenzyme A oxidase 1, palmitoyl ACOX1
Acid phosphatase 2, lysosomal ACP2
Acid phosphatase, prostate ACPP
Actin, gamma 2, smooth muscle, enteric ACTG2
Aspartoacylase (aminocyclase) 3 ACY3
AF4/FMR2 family, member 3 AFF3
AF4/FMR2 family, member 4 AFF4
Aryl hydrocarbon receptor AHR
Absent in melanoma 2 AIM2
V-akt murine thymoma viral oncogene homolog 2 AKT2
Aminolevulinate, delta-, synthase 1 ALAS1
Activated leukocyte cell adhesion molecule ALCAM
Aldehyde dehydrogenase 1 family, member A2 ALDH1A2
Anaplastic lymphoma kinase (Ki-1) ALK
Arachidonate 12-lipoxygenase ALOX12
Arachidonate 15-lipoxygenase, type B ALOX15B
Alpha-methylacyl-CoA racemase AMACR
Alanyl (membrane) aminopeptidase (aminopeptidase N, ANPEP
aminopeptidase M, microsomal aminopeptidase, CD13,
p150)
Anthrax toxin receptor 2 ANTXR2
Annexin A2 ANXA2
APEX nuclease (multifunctional DNA repair enzyme) 1 APEX1
Androgen receptor (dihydrotestosterone receptor; testicular AR
feminization; spinal and bulbar muscular atrophy; Kennedy
disease)
V-raf murine sarcoma 3611 viral oncogene homolog ARAF
Amphiregulin (schwannoma-derived growth factor) AREG
AT rich interactive domain 4A (RBP1-like) ARID4A
Armadillo repeat containing 5 ARMC5
Aryl hydrocarbon receptor nuclear translocator ARNT
N-acylsphingosine amidohydrolase (acid ceramidase)-like ASAHL
ATPase family, AAA domain containing 2 ATAD2
Activating transcription factor 1 ATF1
Ataxia telangiectasia mutated ATM
Atrophin 1 ATN1
ATP synthase, H+ transporting, mitochondrial F1 complex, ATP5D
delta subunit
ATP synthase, H+ transporting, mitochondrial F0 complex, ATP5J
subunit F6
Aurora kinase A AURKA
Aurora kinase B AURKB
AXL receptor tyrosine kinase AXL
Beta-2-microglobulin B2M
BCL2-antagonist of cell death BAD
BAI1-associated protein 2-like 2 BAIAP2L2
BCL2-antagonist/killer 1 BAK1
BRCA1 associated protein-1 (ubiquitin carboxy-terminal BAP1
hydrolase)
BRCA1 associated RING domain 1 BARD1
B-cell CLL/lymphoma 2 BCL2
BCL2-like 1 BCL2L1
B-cell CLL/lymphoma 3 BCL3
Breakpoint cluster region BCR
BCS1-like (yeast) BCS1L
Biglycan BGN
Baculoviral IAP repeat-containing 2 BIRC2
Baculoviral IAP repeat-containing 3 BIRC3
Baculoviral IAP repeat-containing 5 (survivin) BIRC5
Baculoviral IAP repeat-containing 7 (livin) BIRC7
Bloom syndrome BLM
BMI1 polycomb ring finger oncogene BMI1
Bone morphogenetic protein 4 BMP4
BolA homolog 2 (E. coli) BOLA2
V-raf murine sarcoma viral oncogene homolog B1 BRAF
Breast cancer 1, early onset BRCA1
Breast cancer 2, early onset BRCA2
BTB (POZ) domain containing 14B BTBD14B
Bruton agammaglobulinemia tyrosine kinase BTK
BUB1 budding uninhibited by benzimidazoles 1 homolog BUB1
(yeast)
Chromosome 15 open reading frame 33 C15orf33
Chromosome 17 open reading frame 56 C17orf56
Chromosome 17 open reading frame 57 C17orf57
Chromosome 1 open reading frame 115 C1orf115
Chromosome 1 open reading frame 77 C1orf77
Chromosome 2 open reading frame 33 C2orf33
Chromosome 2 open reading frame 37 C2orf37
Chromosome 3 open reading frame 14 C3orf14
Chromosome 8 open reading frame 32 C8orf32
Chromosome 8 open reading frame 53 C8orf53
Chromosome 8 open reading frame 76 C8orf76
Calcium channel, voltage-dependent, beta 4 subunit CACNB4
Calmodulin binding transcription activator 1 CAMTA1
Caspase 2, apoptosis-related cysteine peptidase (neural CASP2
precursor cell expressed, developmentally down-regulated
2)
Caspase 3, apoptosis-related cysteine peptidase CASP3
Caspase 8, apoptosis-related cysteine peptidase CASP8
Caveolin 1, caveolae protein, 22 kDa CAV1
Cas-Br-M (murine) ecotropic retroviral transforming CBL
sequence
Cholecystokinin CCK
Cyclin A2 CCNA2
Cyclin B1 CCNB1
Cyclin C CCNC
Cyclin D1 CCND1
Cyclin E1 CCNE1
Cyclin H CCNH
CD34 molecule CD34
CD38 molecule CD38
CD40 molecule, TNF receptor superfamily member 5 CD40
CD44 molecule (Indian blood group) CD44
CD59 molecule, complement regulatory protein CD59
CD69 molecule CD69
CD9 molecule CD9
Cell division cycle 2, G1 to S and G2 to M CDC2
Cell division cycle 25 homolog A (S. pombe) CDC25A
Cell division cycle 25 homolog B (S. pombe) CDC25B
Cell division cycle 25 homolog C (S. pombe) CDC25C
CDC42 effector protein (Rho GTPase binding) 5 CDC42EP5
Cadherin 1, type 1, E-cadherin (epithelial) CDH1
Cadherin 11, type 2, OB-cadherin (osteoblast) CDH11
Cadherin 13, H-cadherin (heart) CDH13
Cyclin-dependent kinase 10 CDK10
Cyclin-dependent kinase 2 CDK2
Cyclin-dependent kinase 4 CDK4
Cyclin-dependent kinase 6 CDK6
Cyclin-dependent kinase 7 CDK7
Cyclin-dependent kinase 9 CDK9
Cyclin-dependent kinase inhibitor 1A (p21, Cip1) CDKN1A
Cyclin-dependent kinase inhibitor 1B (p27, Kip1) CDKN1B
CDKN2A interacting protein N-terminal like CDKN2AIPNL
Cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4) CDKN2C
Cyclin-dependent kinase inhibitor 3 (CDK2-associated dual CDKN3
specificity phosphatase)
CCAAT/enhancer binding protein (C/EBP), alpha CEBPA
Centrosomal protein 135 kDa CEP135
Centrosomal protein 70 kDa CEP70
Chromatin assembly factor 1, subunit A (p150) CHAF1A
CHK1 checkpoint homolog (S. pombe) CHEK1
Chromogranin A (parathyroid secretory protein 1) CHGA
Chromatin accessibility complex 1 CHRAC1
Ceroid-lipofuscinosis, neuronal 5 CLN5
Clusterin CLU
Calponin 1, basic, smooth muscle CNN1
Cannabinoid receptor 1 (brain) CNR1
Collagen, type XVIII, alpha 1 COL18A1
Collagen, type I, alpha 1 COL1A1
Collagen, type IV, alpha 3 (Goodpasture antigen) COL4A3
COMM domain containing 5 COMMD5
Catechol-O-methyltransferase COMT
Coatomer protein complex, subunit beta 2 (beta prime) COPB2
COP9 constitutive photomorphogenic homolog subunit 5 COPS5
(Arabidopsis)
Cytoplasmic polyadenylation element binding protein 3 CPEB3
Cysteine-rich secretory protein 3 CRISP3
V-crk sarcoma virus CT10 oncogene homolog (avian) CRK
V-crk sarcoma virus CT10 oncogene homolog (avian)-like CRKL
Colony stimulating factor 1 receptor, formerly McDonough CSF1R
feline sarcoma viral (v-fms) oncogene homolog
Colony stimulating factor 2 (granulocyte-macrophage) CSF2
Colony stimulating factor 3 receptor (granulocyte) CSF3R
C-src tyrosine kinase CSK
Cystatin B (stefin B) CSTB
Connective tissue growth factor CTGF
Collagen triple helix repeat containing 1 CTHRC1
Catenin (cadherin-associated protein), alpha 1, 102 kDa CTNNA1
Catenin (cadherin-associated protein), beta 1, 88 kDa CTNNB1
Cathepsin B CTSB
Cathepsin L1 CTSL1
Cortactin CTTN
Cullin 2 CUL2
Chemokine (C—X—C motif) ligand 14 CXCL14
Chemokine (C—X—C motif) ligand 9 CXCL9
Chromosome X open reading frame 41 CXorf41
Cytochrome b5 type A (microsomal) CYB5A
Cytoplasmic FMR1 interacting protein 1 CYFIP1
Cytochrome P450, family 27, subfamily A, polypeptide 1 CYP27A1
Cytochrome P450, family 2, subfamily C, polypeptide 9 CYP2C9
Cytochrome P450, family 3, subfamily A, polypeptide 5 CYP3A5
Disabled homolog 2, mitogen-responsive phosphoprotein DAB2
(Drosophila)
Death associated protein 3 DAP3
Death-associated protein kinase 1 DAPK1
Deleted in colorectal carcinoma DCC
Dodecenoyl-Coenzyme A delta isomerase (3,2 trans-enoyl- DCI
Coenzyme A isomerase)
Decorin DCN
Dynactin 2 (p50) DCTN2
Damage-specific DNA binding protein 2, 48 kDa DDB2
Dopa decarboxylase (aromatic L-amino acid decarboxylase) DDC
Development and differentiation enhancing factor 1 DDEF1
DNA-damage-inducible transcript 3 DDIT3
DEAD (Asp-Glu-Ala-Asp) box polypeptide 6 DDX6
2,4-dienoyl CoA reductase 2, peroxisomal DECR2
DEK oncogene (DNA binding) DEK
DENN/MADD domain containing 3 DENND3
DEP domain containing 1B DEPDC1B
DEP domain containing 6 DEPDC6
Diacylglycerol kinase, alpha 80 kDa DGKA
DEAH (Asp-Glu-Ala-His) box polypeptide 9 DHX9
Deiodinase, iodothyronine, type II DIO2
DIRAS family, GTP-binding RAS-like 3 DIRAS3
Dyskeratosis congenita 1, dyskerin DKC1
DKEZP564O0823 protein DKEZP564O0823
Discs, large homolog 3 (neuroendocrine-dlg, Drosophila) DLG3
Discs, large (Drosophila) homolog-associated protein 1 DLGAP1
Deleted in malignant brain tumors 1 DMBT1
Dedicator of cytokinesis 5 DOCK5
Desmoplakin DSP
E2F transcription factor 1 E2F1
E2F transcription factor 2 E2F2
E2F transcription factor 3 E2F3
E2F transcription factor 4, p107/p130-binding E2F4
Endothelial differentiation, lysophosphatidic acid G-protein- EDG7
coupled receptor, 7
Endothelin receptor type B EDNRB
Eukaryotic translation elongation factor 1 alpha 1 EEF1A1
Embryonal Fyn-associated substrate EFS
Epidermal growth factor (beta-urogastrone) EGF
Epidermal growth factor receptor (erythroblastic leukemia EGFR
viral (v-erb-b) oncogene homolog, avian)
Early growth response 2 (Krox-20 homolog, Drosophila) EGR2
Early growth response 3 EGR3
Euchromatic histone-lysine N-methyltransferase 1 EHMT1
Euchromatic histone-lysine N-methyltransferase 2 EHMT2
Eukaryotic translation initiation factor 2-alpha kinase 2 EIF2AK2
Eukaryotic translation initiation factor 3, subunit H EIF3H
ELK1, member of ETS oncogene family ELK1
ELK3, ETS-domain protein (SRF accessory protein 2) ELK3
Elongation factor RNA polymerase II ELL
Elongation factor RNA polymerase II-like 3 ELL3
Epithelial membrane protein 2 EMP2
Ectonucleotide pyrophosphatase/phosphodiesterase 2 ENPP2
(autotaxin)
Enhancer of yellow 2 homolog (Drosophila) ENY2
EPH receptor A1 EPHA1
EPH receptor B4 EPHB4
Epsin 1 EPN1
Erythropoietin EPO
Epidermal growth factor receptor pathway substrate 15 EPS15
Epidermal growth factor receptor pathway substrate 8 EPS8
V-erb-b2 erythroblastic leukemia viral oncogene homolog 2, ERBB2
neuro/glioblastoma derived oncogene homolog (avian)
V-erb-b2 erythroblastic leukemia viral oncogene homolog 3 ERBB3
(avian)
V-erb-a erythroblastic leukemia viral oncogene homolog 4 ERBB4
(avian)
Excision repair cross-complementing rodent repair ERCC1
deficiency, complementation group 1 (includes overlapping
antisense sequence)
Excision repair cross-complementing rodent repair ERCC2
deficiency, complementation group 2 (xeroderma
pigmentosum D)
Excision repair cross-complementing rodent repair ERCC3
deficiency, complementation group 3 (xeroderma
pigmentosum group B complementing)
Excision repair cross-complementing rodent repair ERCC4
deficiency, complementation group 4
Excision repair cross-complementing rodent repair ERCC5
deficiency, complementation group 5 (xeroderma
pigmentosum, complementation group G (Cockayne
syndrome))
Excision repair cross-complementing rodent repair ERCC6
deficiency, complementation group 6
V-ets erythroblastosis virus E26 oncogene homolog (avian) ERG
Endoplasmic reticulum to nucleus signaling 2 ERN2
Estrogen receptor 1 ESR1
Estrogen receptor 2 (ER beta) ESR2
V-ets erythroblastosis virus E26 oncogene homolog 1 ETS1
(avian)
V-ets erythroblastosis virus E26 oncogene homolog 2 ETS2
(avian)
Ets variant gene 1 ETV1
Ets variant gene 4 (E1A enhancer binding protein, E1AF) ETV4
Ets variant gene 6 (TEL oncogene) ETV6
Even-skipped homeobox 1 EVX1
Exocyst complex component 2 EXOC2
Exostoses (multiple) 1 EXT1
Exostoses (multiple) 2 EXT2
Enhancer of zeste homolog 2 (Drosophila) EZH2
Ezrin EZR
Coagulation factor II (thrombin) receptor F2R
Coagulation factor V (proaccelerin, labile factor) F5
Family with sequence similarity 114, member A1 FAM114A1
Family with sequence similarity 13, member C1 FAM13C1
Family with sequence similarity 49, member B FAM49B
Family with sequence similarity 84, member B FAM84B
Family with sequence similarity 8, member A1 FAM8A1
Fanconi anemia, complementation group A FANCA
Fanconi anemia, complementation group G FANCG
Fas (TNF receptor superfamily, member 6) FAS
Fas ligand (TNF superfamily, member 6) FASLG
Fatty acid synthase FASN
Fibulin 1 FBLN1
F-box protein 32 FBXO32
F-box and WD repeat domain containing 11 FBXW11
Farnesyl diphosphate synthase (farnesyl pyrophosphate FDPS
synthetase, dimethylallyltranstransferase,
geranyltranstransferase)
Fer (fps/fes related) tyrosine kinase (phosphoprotein FER
NCP94)
Feline sarcoma oncogene FES
FEV (ETS oncogene family) FEV
Fibroblast growth factor 12 FGF12
Fibroblast growth factor 3 (murine mammary tumor virus FGF3
integration site (v-int-2) oncogene homolog)
Fibroblast growth factor 5 FGF5
Fibroblast growth factor 8 (androgen-induced) FGF8
Fibroblast growth factor 9 (glia-activating factor) FGF9
Fibroblast growth factor receptor 1 (fms-related tyrosine FGFR1
kinase 2, Pfeiffer syndrome)
Fibroblast growth factor receptor 2 (bacteria-expressed FGFR2
kinase, keratinocyte growth factor receptor, craniofacial
dysostosis 1, Crouzon syndrome, Pfeiffer syndrome,
Jackson-Weiss syndrome)
Fibroblast growth factor receptor 4 FGFR4
Fragile histidine triad gene FHIT
Folliculin FLCN
Friend leukemia virus integration 1 FLI1
Hypothetical protein FLJ90709 FLJ90709
Fms-related tyrosine kinase 1 (vascular endothelial growth FLT1
factor/vascular permeability factor receptor)
Fms-related tyrosine kinase 4 FLT4
Flavin containing monooxygenase 5 FMO5
Fibromodulin FMOD
Folate hydrolase (prostate-specific membrane antigen) 1 FOLH1
Folate receptor 1 (adult) FOLR1
V-fos FBJ murine osteosarcoma viral oncogene homolog FOS
FK506 binding protein 12-rapamycin associated protein 1 FRAP1
Frizzled-related protein FRZB
FYN oncogene related to SRC, FGR, YES FYN
Frizzled homolog 7 (Drosophila) FZD7
Gamma-aminobutyric acid (GABA) A receptor, gamma 2 GABRG2
Growth arrest and DNA-damage-inducible, alpha GADD45A
G protein beta subunit-like GBL
Gastrulation brain homeobox 2 GBX2
Ganglioside-induced differentiation-associated protein 1 GDAP1
Growth differentiation factor 15 GDF15
Glioma-associated oncogene homolog 1 (zinc finger protein) GLI1
Glutaredoxin 2 GLRX2
GPI anchored molecule like protein GML
Geminin, DNA replication inhibitor GMNN
Guanine nucleotide binding protein (G protein), alpha 15 GNA15
GNAS complex locus GNAS
Guanine nucleotide binding protein (G protein), beta GNB1
polypeptide 1
Glucosamine (UDP-N-acetyl)-2-epimerase/N- GNE
acetylmannosamine kinase
N-acetylglucosamine-1-phosphate transferase, alpha and GNPTAB
beta subunits
Golgi membrane protein 1 GOLM1
Golgi-localized protein GOLSYN
G protein-coupled receptor 137B GPR137B
Growth factor receptor-bound protein 2 GRB2
Growth factor receptor-bound protein 7 GRB7
Gremlin 2, cysteine knot superfamily, homolog (Xenopus GREM2
laevis)
Gastrin-releasing peptide receptor GRPR
Glycogen synthase kinase 3 alpha GSK3A
Glutathione S-transferase pi GSTP1
Glucuronidase, beta GUSB
H1 histone family, member X H1FX
Heparin-binding EGF-like growth factor HBEGF
HCCA2 protein HCCA2
Host cell factor C1 (VP16-accessory protein) HCFC1
Hemopoietic cell kinase HCK
Histone deacetylase 1 HDAC1
Histone deacetylase 7A HDAC7A
Hepatoma-derived growth factor (high-mobility group HDGF
protein 1-like)
HECT, C2 and WW domain containing E3 ubiquitin protein HECW2
ligase 2
Hypoxia-inducible factor 1, alpha subunit (basic helix-loop- HIF1A
helix transcription factor)
Hydroxymethylbilane synthase HMBS
3-hydroxy-3-methylglutaryl-Coenzyme A reductase HMGCR
Hyaluronan-mediated motility receptor (RHAMM) HMMR
Hook homolog 1 (Drosophila) HOOK1
Homeobox A9 HOXA9
Homeobox C4 HOXC4
Hepsin (transmembrane protease, serine 1) HPN
Hypoxanthine phosphoribosyltransferase 1 (Lesch-Nyhan HPRT1
syndrome)
V-Ha-ras Harvey rat sarcoma viral oncogene homolog HRAS
Hydroxysteroid (17-beta) dehydrogenase 4 HSD17B4
Hydroxysteroid (17-beta) dehydrogenase 6 homolog HSD17B6
(mouse)
Heat shock transcription factor 4 HSF4
Heat shock 27 kDa protein 1 HSPB1
Intercellular adhesion molecule 1 (CD54), human rhinovirus ICAM1
receptor
Immediate early response 3 IER3
Interferon, gamma IFNG
Interferon gamma receptor 1 IFNGR1
Insulin-like growth factor 1 (somatomedin C) IGF1
Insulin-like growth factor 1 receptor IGF1R
Insulin-like growth factor 2 receptor IGF2R
Insulin-like growth factor binding protein 1 IGFBP1
Insulin-like growth factor binding protein 2, 36 kDa IGFBP2
Insulin-like growth factor binding protein 3 IGFBP3
Insulin-like growth factor binding protein 6 IGFBP6
IKAROS family zinc finger 1 (Ikaros) IKZF1
Interleukin 11 IL11
Interleukin 12A (natural killer cell stimulatory factor 1, IL12A
cytotoxic lymphocyte maturation factor 1, p35)
Interleukin 12B (natural killer cell stimulatory factor 2, IL12B
cytotoxic lymphocyte maturation factor 2, p40)
Interleukin 13 IL13
Interleukin 1, beta IL1B
Interleukin 2 IL2
Interleukin 3 (colony-stimulating factor, multiple) IL3
Interleukin 4 IL4
Interleukin 6 (interferon, beta 2) IL6
Interleukin 6 receptor IL6R
Interleukin 8 IL8
Integrin-linked kinase ILK
Inner membrane protein, mitochondrial (mitofilin) IMMT
Inhibin, alpha INHA
Inhibin, beta A INHBA
Interferon regulatory factor 1 IRF1
Insulin receptor substrate 2 IRS2
ISL LIM homeobox 1 ISL1
Integrin, alpha V (vitronectin receptor, alpha polypeptide, ITGAV
antigen CD51)
Integrin, beta 1 (fibronectin receptor, beta polypeptide, ITGB1
antigen CD29 includes MDF2, MSK12)
Integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) ITGB3
Integrin, beta 4 ITGB4
Inositol 1,4,5-trisphosphate 3-kinase A ITPKA
Inositol 1,4,5-triphosphate receptor, type 1 ITPR1
Isovaleryl Coenzyme A dehydrogenase IVD
Janus kinase 2 (a protein tyrosine kinase) JAK2
Jumonji, AT rich interactive domain 1A JARID1A
Jumonji domain containing 2B JMJD2B
Jun oncogene JUN
Jun B proto-oncogene JUNB
Jun D proto-oncogene JUND
Potassium channel regulator KCNRG
Kinase insert domain receptor (a type III receptor tyrosine KDR
kinase)
KH domain containing, RNA binding, signal transduction KHDRBS3
associated 3
KIAA0196 KIAA0196
KIAA0922 KIAA0922
KIAA1324 KIAA1324
Kinesin family member C2 KIFC2
V-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene KIT
homolog
Kruppel-like factor 6 KLF6
Ketch domain containing 4 KLHDC4
Kallikrein-related peptidase 2 KLK2
Kallikrein-related peptidase 3 KLK3
Kallikrein-related peptidase 4 KLK4
Karyopherin (importin) beta 1 KPNB1
Keratin 15 KRT15
Keratin 5 (epidermolysis bullosa simplex, Dowling- KRT5
Meara/Kobner/Weber-Cockayne types)
L1 cell adhesion molecule L1CAM
Lymphocyte-specific protein tyrosine kinase LCK
Lipocalin 2 LCN2
Leprecan-like 1 LEPREL1
Leucine-rich repeat-containing G protein-coupled receptor 4 LGR4
Ligase I, DNA, ATP-dependent LIG1
Ligase III, DNA, ATP-dependent LIG3
LIM domain only 1 (rhombotin 1) LMO1
LIM domain only 2 (rhombotin-like 1) LMO2
Poly (ADP-ribose) polymerase family, member 1 LOC649459
Lactotransferrin LOC728320
Hypothetical protein BC008326 LOC89944
Lysyl oxidase LOX
Leucine rich repeat containing 2 LRRC2
Limbic system-associated membrane protein LSAMP
Latent transforming growth factor beta binding protein 2 LTBP2
Mal, T-cell differentiation protein-like MALL
Mucosa associated lymphoid tissue lymphoma translocation MALT1
gene 1
Monoamine oxidase B MAOB
Mitogen-activated protein kinase kinase 6 MAP2K6
Mitogen-activated protein kinase kinase kinase 8 MAP3K8
Mitogen-activated protein kinase 1 MAPK1
Mitogen-activated protein kinase 10 MAPK10
Mitogen-activated protein kinase 14 MAPK14
MARCKS-like 1 MARCKSL1
MARVEL domain containing 3 MARVELD3
MAS1 oncogene MAS1
Megakaryocyte-associated tyrosine kinase MATK
Methyl-CpG binding domain protein 2 MBD2
Melanoma cell adhesion molecule MCAM
Mutated in colorectal cancers MCC
MCF.2 cell line derived transforming sequence MCF2
Myeloid cell leukemia sequence 1 (BCL2-related) MCL1
Minichromosome maintenance complex component 7 MCM7
Microcephalin 1 MCPH1
Mdm4, transformed 3T3 cell double minute 4, p53 binding MDM4
protein (mouse)
Mediator complex subunit 30 MED30
Myocyte enhancer factor 2C MEF2C
Meis homeobox 2 MEIS2
Multiple endocrine neoplasia I MEN1
Met proto-oncogene (hepatocyte growth factor receptor) MET
Methyltransferase 10 domain containing METT10D
Hypothetical protein MGC15523 MGC15523
Antigen identified by monoclonal antibody Ki-67 MKI67
Myeloid leukemia factor 1 MLF1
Myeloid leukemia factor 2 MLF2
MutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli) MLH1
Myeloid/lymphoid or mixed-lineage leukemia (trithorax MLLT3
homolog, Drosophila); translocated to, 3
Myeloid/lymphoid or mixed-lineage leukemia (trithorax MLLT4
homolog, Drosophila); translocated to, 4
Myeloid/lymphoid or mixed-lineage leukemia (trithorax MLLT6
homolog, Drosophila); translocated to, 6
Matrix metallopeptidase 1 (interstitial collagenase) MMP1
Matrix metallopeptidase 10 (stromelysin 2) MMP10
Matrix metallopeptidase 14 (membrane-inserted) MMP14
Matrix metallopeptidase 2 (gelatinase A, 72 kDa gelatinase, MMP2
72 kDa type IV collagenase)
Matrix metallopeptidase 3 (stromelysin 1, progelatinase) MMP3
Matrix metallopeptidase 7 (matrilysin, uterine) MMP7
Matrix metallopeptidase 9 (gelatinase B, 92 kDa gelatinase, MMP9
92 kDa type IV collagenase)
V-mos Moloney murine sarcoma viral oncogene homolog MOS
Membrane protein, palmitoylated 7 (MAGUK p55 MPP7
subfamily member 7)
Mitochondrial ribosomal protein L13 MRPL13
MutS homolog 2, colon cancer, nonpolyposis type 1 (E. coli) MSH2
MutS homolog 3 (E. coli) MSH3
MutS homolog 6 (E. coli) MSH6
Microseminoprotein, beta- MSMB
Macrophage scavenger receptor 1 MSR1
Macrophage stimulating 1 receptor (c-met-related tyrosine MST1R
kinase)
Metastasis associated 1 MTA1
5,10-methylenetetrahydrofolate reductase (NADPH) MTHFR
Myotrophin MTPN
5-methyltetrahydrofolate-homocysteine methyltransferase MTR
Metastasis suppressor 1 MTSS1
Mucin 1, cell surface associated MUC1
MAX dimerization protein 1 MXD1
MAX interactor 1 MXI1
V-myb myeloblastosis viral oncogene homolog (avian) MYB
V-myb myeloblastosis viral oncogene homolog (avian)-like 2 MYBL2
Myosin binding protein C, slow type MYBPC1
V-myc myelocytomatosis viral oncogene homolog (avian) MYC
V-myc myelocytomatosis viral related oncogene, MYCN
neuroblastoma derived (avian)
Myosin, heavy chain 11, smooth muscle MYH11
Myosin, light chain 9, regulatory MYL9
Myosin, light chain kinase MYLK
N-acetyltransferase 2 (arylamine N-acetyltransferase) NAT2
Neuroblastoma, suppression of tumorigenicity 1 NBL1
Nibrin NBN
Non-SMC condensin II complex, subunit D3 NCAPD3
N-myc downstream regulated gene 1 NDRG1
NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 9, NDUFB9
22 kDa
Neurofilament, heavy polypeptide 200 kDa NEFH
Neogenin homolog 1 (chicken) NEO1
Neuropilin (NRP) and tolloid (TLL)-like 2 NETO2
Neurofibromin 1 (neurofibromatosis, von Recklinghausen NF1
disease, Watson disease)
Nuclear factor of kappa light polypeptide gene enhancer in NFKB1
B-cells 1 (p105)
Nuclear factor of kappa light polypeptide gene enhancer in NFKB2
B-cells 2 (p49/p100)
Nuclear factor of kappa light polypeptide gene enhancer in NFKBIA
B-cells inhibitor, alpha
Nitric oxide synthase 3 (endothelial cell) NOS3
Notch homolog 1, translocation-associated (Drosophila) NOTCH1
Notch homolog 2 (Drosophila) NOTCH2
Notch homolog 4 (Drosophila) NOTCH4
Nephroblastoma overexpressed gene NOV
NADPH oxidase 4 NOX4
Aminopeptidase-like 1 NPEPL1
NAD(P)H dehydrogenase, quinone 1 NQO1
Nuclear receptor subfamily 4, group A, member 1 NR4A1
Neuroblastoma RAS viral (v-ras) oncogene homolog NRAS
Neuropilin 1 NRP1
Neurotrophic tyrosine kinase, receptor, type 1 NTRK1
Neurotrophic tyrosine kinase, receptor, type 2 NTRK2
Neurotrophic tyrosine kinase, receptor, type 3 NTRK3
Nuclear mitotic apparatus protein 1 NUMA1
Nucleoporin 98 kDa NUP98
Ornithine decarboxylase antizyme 2 OAZ2
Oxysterol binding protein-like 9 OSBPL9
P antigen family, member 4 (prostate associated) PAGE4
PAP associated domain containing 1 PAPD1
Par-3 partitioning defective 3 homolog (C. elegans) PARD3
PAS domain containing serine/threonine kinase PASK
Pre-B-cell leukemia homeobox 1 PBX1
Proliferating cell nuclear antigen PCNA
PCTAIRE protein kinase 1 PCTK1
Platelet-derived growth factor alpha polypeptide PDGFA
Platelet-derived growth factor receptor, alpha polypeptide PDGFRA
Platelet-derived growth factor receptor, beta polypeptide PDGFRB
Protein disulfide isomerase family A, member 5 PDIA5
PDZ and LIM domain 5 PDLIM5
Phosphatidylethanolamine-binding protein 4 PEBP4
Phosphatidylethanolamine N-methyltransferase PEMT
Placental growth factor, vascular endothelial growth factor- PGF
related protein
Phosphoglycerate kinase 1 PGK1
Progesterone receptor PGR
Phosphatase and actin regulator 2 PHACTR2
PHD finger protein 20-like 1 PHF20L1
PHD finger protein 8 PHF8
Phytanoyl-CoA 2-hydroxylase interacting protein-like PHYHIPL
Protein inhibitor of activated STAT, 2 PIAS2
Phosphoinositide-3-kinase, catalytic, alpha polypeptide PIK3CA
Phosphoinositide-3-kinase, catalytic, delta polypeptide PIK3CD
Polycystic kidney and hepatic disease 1 (autosomal PKHD1L1
recessive)-like 1
Phospholipase A2, group IIA (platelets, synovial fluid) PLA2G2A
Phospholipase A2, group VII (platelet-activating factor PLA2G7
acetylhydrolase, plasma)
Pleiomorphic adenoma gene 1 PLAG1
Plasminogen activator, tissue PLAT
Plasminogen activator, urokinase receptor PLAUR
Plasminogen PLG
Plexin domain containing 1 PLXDC1
Promyelocytic leukemia PML
PMS1 postmeiotic segregation increased 1 (S. cerevisiae) PMS1
Polymerase (RNA) I polypeptide C, 30 kDa POLR1C
Periostin, osteoblast specific factor POSTN
POU class 2 homeobox 1 POU2F1
Peroxisome proliferator-activated receptor delta PPARD
Peroxisome proliferator-activated receptor gamma PPARG
Protein phosphatase 2 (formerly 2A), regulatory subunit A, PPP2R1B
beta isoform
Papillary renal cell carcinoma (translocation-associated) PRCC
Peroxisomal proliferator-activated receptor A interacting PRIC285
complex 285
Protein kinase, cAMP-dependent, regulatory, type I, alpha PRKAR1A
(tissue specific extinguisher 1)
Protease, serine, 8 PRSS8
Prostate stem cell antigen PSCA
Proteasome (prosome, macropain) 26S subunit, non- PSMD1
ATPase, 1
Patched homolog 1 (Drosophila) PTCH1
Patched homolog 2 (Drosophila) PTCH2
Prostaglandin E receptor 3 (subtype EP3) PTGER3
Prostaglandin-endoperoxide synthase 1 (prostaglandin G/H PTGS1
synthase and cyclooxygenase)
Prostaglandin-endoperoxide synthase 2 (prostaglandin G/H PTGS2
synthase and cyclooxygenase)
Parathyroid hormone-like hormone PTHLH
PTK2 protein tyrosine kinase 2 PTK2
PTK7 protein tyrosine kinase 7 PTK7
Pleiotrophin (heparin binding growth factor 8, neurite PTN
growth-promoting factor 1)
Protein tyrosine phosphatase type IVA, member 3 PTP4A3
Protein tyrosine phosphatase-like (proline instead of PTPLB
catalytic arginine), member b
Protein tyrosine phosphatase, receptor type, F PTPRF
Protein tyrosine phosphatase, receptor type, G PTPRG
Protein tyrosine phosphatase, receptor type, H PTPRH
Protein tyrosine phosphatase, receptor type, N polypeptide 2 PTPRN2
Poly-U binding splicing factor 60 KDa PUF60
Purine-rich element binding protein A PURA
Paxillin PXN
Pyrroline-5-carboxylate reductase 1 PYCR1
Pyrroline-5-carboxylate reductase-like PYCRL
Glutaminyl-tRNA synthetase QARS
RAB32, member RAS oncogene family RAB32
RAB8A, member RAS oncogene family RAB8A
Rabaptin, RAB GTPase binding effector protein 2 RABEP2
RAD21 homolog (S. pombe) RAD21
RAD23 homolog A (S. cerevisiae) RAD23A
RAD50 homolog (S. cerevisiae) RAD50
RAD54 homolog B (S. cerevisiae) RAD54B
V-raf-1 murine leukemia viral oncogene homolog 1 RAF1
V-ral simian leukemia viral oncogene homolog B (ras RALB
related; GTP binding protein)
RAP1, GTP-GDP dissociation stimulator 1 RAP1GDS1
RAP2A, member of RAS oncogene family RAP2A
Retinoic acid receptor, alpha RARA
RAS p21 protein activator (GTPase activating protein) 1 RASA1
Retinoblastoma 1 (including osteosarcoma) RB1
Retinoblastoma binding protein 6 RBBP6
Retinoblastoma-like 2 (p130) RBL2
Retinol dehydrogenase 11 (all-trans/9-cis/11-cis) RDH11
RecQ protein-like (DNA helicase Q1-like) RECQL
RecQ protein-like 4 RECQL4
V-rel reticuloendotheliosis viral oncogene homolog (avian) REL
V-rel reticuloendotheliosis viral oncogene homolog A, RELA
nuclear factor of kappa light polypeptide gene enhancer in
B-cells 3, p65 (avian)
Ret proto-oncogene RET
Ras homolog gene family, member A RHOA
Ras homolog gene family, member H RHOH
Receptor (TNFRSF)-interacting serine-threonine kinase 1 RIPK1
Relaxin 1 RLN1
Ring finger protein 139 RNF139
Ring finger protein 185 RNF185
V-ros UR2 sarcoma virus oncogene homolog 1 (avian) ROS1
Replication protein A1, 70 kDa RPA1
Ras-related GTP binding C RRAGC
Related RAS viral (r-ras) oncogene homolog RRAS
Rhabdoid tumor deletion region gene 1 RTDR1
S100 calcium binding protein A4 S100A4
Sterile alpha motif domain containing 12 SAMD12
Stearoyl-CoA desaturase 5 SCD5
Sodium channel and clathrin linker 1 SCLT1
Sodium channel, nonvoltage-gated 1 alpha SCNN1A
Scribbled homolog (Drosophila) SCRIB
Syndecan 2 SDC2
Succinate dehydrogenase complex, subunit B, iron sulfur SDHB
(Ip)
Succinate dehydrogenase complex, subunit C, integral SDHC
membrane protein, 15 kDa
SEC14-like 1 (S. cerevisiae) SEC14L1
Sema domain, immunoglobulin domain (Ig), short basic SEMA3F
domain, secreted, (semaphorin) 3F
Serpin peptidase inhibitor, clade B (ovalbumin), member 5 SERPINB5
Serpin peptidase inhibitor, clade I (neuroserpin), member 1 SERPINI1
Splicing factor 1 SF1
Secreted frizzled-related protein 4 SFRP4
SH3-domain binding protein 2 SH3BP2
SH3 domain containing ring finger 2 SH3RF2
Sonic hedgehog homolog (Drosophila) SHH
Seven in absentia homolog 1 (Drosophila) SIAH1
V-ski sarcoma viral oncogene homolog (avian) SKI
SKI-like oncogene SKIL
Solute carrier family 14 (urea transporter), member 1 (Kidd SLC14A1
blood group)
Solute carrier family 20 (phosphate transporter), member 1 SLC20A1
Solute carrier family 22 (extraneuronal monoamine SLC22A3
transporter), member 3
Solute carrier family 25, member 42 SLC25A42
Solute carrier family 44, member 1 SLC44A1
Solute carrier family 45, member 3 SLC45A3
SMAD family member 4 SMAD4
SWI/SNF related, matrix associated, actin dependent SMARCB1
regulator of chromatin, subfamily b, member 1
SWI/SNF related, matrix associated, actin dependent SMARCC1
regulator of chromatin, subfamily c, member 1
Sphingomyelin phosphodiesterase, acid-like 3B SMPDL3B
Small nuclear ribonucleoprotein polypeptide E SNRPE
Syntrophin, beta 1 (dystrophin-associated protein A1, SNTB1
59 kDa, basic component 1)
Syntrophin, beta 2 (dystrophin-associated protein A1, SNTB2
59 kDa, basic component 2)
Syntrophin, gamma 1 SNTG1
Suppressor of cytokine signaling 7 SOCS7
Superoxide dismutase 1, soluble (amyotrophic lateral SOD1
sclerosis 1 (adult))
Secreted protein, acidic, cysteine-rich (osteonectin) SPARC
SAM pointed domain containing ets transcription factor SPDEF
Spleen focus forming virus (SFFV) proviral integration SPI1
oncogene spi1
Secreted phosphoprotein 1 (osteopontin, bone sialoprotein I, SPP1
early T-lymphocyte activation 1)
Squalene epoxidase SQLE
Sulfide quinone reductase-like (yeast) SQRDL
V-src sarcoma (Schmidt-Ruppin A-2) viral oncogene SRC
homolog (avian)
Steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 SRD5A2
alpha-steroid delta 4-dehydrogenase alpha 2)
ST3 beta-galactoside alpha-2,3-sialyltransferase 1 ST3GAL1
ST3 beta-galactoside alpha-2,3-sialyltransferase 5 ST3GAL5
ST6 beta-galactosamide alpha-2,6-sialyltranferase 1 ST6GAL1
Suppression of tumorigenicity 7 ST7
Signal transducer and activator of transcription 1, 91 kDa STAT1
Signal transducer and activator of transcription 3 (acute- STAT3
phase response factor)
Signal transducer and activator of transcription 5B STAT5B
Six transmembrane epithelial antigen of the prostate 2 STEAP2
Stress-induced-phosphoprotein 1 (Hsp70/Hsp90-organizing STIP1
protein)
Serine/threonine kinase 11 STK11
Spleen tyrosine kinase SYK
Synapsin I SYN1
Synapsin III SYN3
Tumor-associated calcium signal transducer 1 TACSTD1
TATA box binding protein (TBP)-associated factor, RNA TAF1C
polymerase I, C, 110 kDa
TAF2 RNA polymerase II, TATA box binding protein TAF2
(TBP)-associated factor, 150 kDa
T-cell acute lymphocytic leukemia 1 TAL1
Tax1 (human T-cell leukemia virus type I) binding protein 1 TAX1BP1
TATA box binding protein TBP
Transcription factor 7-like 2 (T-cell specific, HMG-box) TCF7L2
TEK tyrosine kinase, endothelial (venous malformations, TEK
multiple cutaneous and mucosal)
Telomerase reverse transcriptase TERT
Transcription factor AP-2 gamma (activating enhancer TFAP2C
binding protein 2 gamma)
Transcription factor Dp-1 TFDP1
Transcription factor binding to IGHM enhancer 3 TFE3
Trefoil factor 1 TFF1
TRK-fused gene TFG
Transferrin receptor (p90, CD71) TFRC
Transforming growth factor, alpha TGFA
Transforming growth factor, beta 1 TGFB1
Transforming growth factor, beta 2 TGFB2
Transforming growth factor, beta 3 TGFB3
Transforming growth factor, beta-induced, 68 kDa TGFBI
Transforming growth factor, beta receptor I (activin A TGFBR1
receptor type II-like kinase, 53 kDa)
Transforming growth factor, beta receptor II (70/80 kDa) TGFBR2
Transforming growth factor, beta receptor III TGFBR3
Transglutaminase 2 (C polypeptide, protein-glutamine- TGM2
gamma-glutamyltransferase)
Thrombospondin 1 THBS1
Thrombospondin 2 THBS2
Thrombopoietin (myeloproliferative leukemia virus THPO
oncogene ligand, megakaryocyte growth and development
factor)
T-cell lymphoma invasion and metastasis 1 TIAM1
TIMP metallopeptidase inhibitor 2 TIMP2
Thymidine kinase 1, soluble TK1
Transmembrane protein with EGF-like and two follistatin- TMEFF2
like domains 2
Transmembrane protein 134 TMEM134
Transmembrane protein 45B TMEM45B
Transmembrane protein 65 TMEM65
Transmembrane protein 71 TMEM71
Transmembrane protease, serine 2 TMPRSS2
Tumor necrosis factor receptor superfamily, member 10a TNFRSF10A
Tumor necrosis factor receptor superfamily, member 10b TNFRSF10B
Tumor necrosis factor receptor superfamily, member 11a, TNFRSF11A
NFKB activator
Tumor necrosis factor receptor superfamily, member 11b TNFRSF11B
(osteoprotegerin)
Tumor necrosis factor receptor superfamily, member 1A TNFRSF1A
Tumor necrosis factor (ligand) superfamily, member 10 TNFSF10
Tumor necrosis factor (ligand) superfamily, member 8 TNFSF8
Topoisomerase (DNA) I TOP1
Topoisomerase (DNA) II alpha 170 kDa TOP2A
Tumor protein p53 (Li-Fraumeni syndrome) TP53
Tumor protein p53 inducible protein 11 TP53I11
Tumor protein p73 TP73
Translocated promoter region (to activated MET oncogene) TPR
TPX2, microtubule-associated, homolog (Xenopus laevis) TPX2
Tripartite motif-containing 38 TRIM38
TRNA methyltransferase 12 homolog (S. cerevisiae) TRMT12
Transient receptor potential cation channel, subfamily M, TRPM8
member 8
Trichorhinophalangeal syndrome I TRPS1
Tuberous sclerosis 1 TSC1
Tuberous sclerosis 2 TSC2
Tetraspanin 13 TSPAN13
Tetraspanin 14 TSPAN14
Tissue specific transplantation antigen P35B TSTA3
Tetratricopeptide repeat domain 29 TTC29
Thymidylate synthetase TYMS
TYRO3 protein tyrosine kinase TYRO3
Ubiquitin-conjugating enzyme E2, J2 (UBC6 homolog, UBE2J2
yeast)
UBX domain containing 3 UBXD3
Vesicle-associated membrane protein 2 (synaptobrevin 2) VAMP2
Vav 1 guanine nucleotide exchange factor VAV1
Vav 2 guanine nucleotide exchange factor VAV2
Versican VCAN
Vascular endothelial growth factor A VEGFA
Vestigial like 3 (Drosophila) VGLL3
Wiskott-Aldrich syndrome (eczema-thrombocytopenia) WAS
WD repeat domain 67 WDR67
WEE1 homolog (S. pombe) WEE1
WNT1 inducible signaling pathway protein 1 WISP1
Wingless-type MMTV integration site family, member 10B WNT10B
Wingless-type MMTV integration site family member 2 WNT2
Wingless-type MMTV integration site family, member 2B WNT2B
Wingless-type MMTV integration site family, member 5A WNT5A
Wingless-type MMTV integration site family, member 8B WNT8B
Werner syndrome WRN
Wilms tumor 1 WT1
Xanthine dehydrogenase XDH
Xeroderma pigmentosum, complementation group A XPA
Xeroderma pigmentosum, complementation group C XPC
X-ray repair complementing defective repair in Chinese XRCC1
hamster cells 1
X-ray repair complementing defective repair in Chinese XRCC4
hamster cells 4
X-ray repair complementing defective repair in Chinese XRCC5
hamster cells 5 (double-strand-break rejoining; Ku
autoantigen, 80 kDa)
X-ray repair complementing defective repair in Chinese XRCC6
hamster cells 6 (Ku autoantigen, 70 kDa)
V-yes-1 Yamaguchi sarcoma viral oncogene homolog 1 YES1
Yip1 domain family, member 1 YIPF1
Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase YWHAB
activation protein, beta polypeptide
Zinc finger protein 36, C3H type, homolog (mouse) ZFP36
Zinc finger protein 313 ZNF313
Zinc finger protein 34 ZNF34
Zinc finger protein 511 ZNF511
Zinc finger protein 7 ZNF7
TABLE 7
RNA transcripts used to derive metagene values for 18-RNA
metagene depicted in FIG. 3. The 6-RNA metagene is a subset
of the sequences listed in Table 7, also depicted in FIG. 3.
18-RNA metagene scores were scaled and normalized to
generate ‘POP’ scores depicted in FIG. 4. Weighting
factors were from the linear regression coefficient values;
positive and negative values indicated transcripts correlated
to increased expression in ‘SYS’ and ‘NED’ disease,
respectively with intermediate expression values in the
‘PSA’ disease group.
SEQ ID No Weights
1 −6.08
2 −5.71
3 −5.68
4 −5.39
5 −5.26
6 −4.84
7 −4.7
8 −4.68
9 −4.66
10 −4.55
11 −4.53
914 5.32
915 5.27
916 4.82
917 4.64
918 4.59
919 4.54
920 4.49
TABLE 8
RNA transcripts used to derive metagene values for 20-RNA
metagene depicted in FIG. 3. Weighting factors were from the
linear regression coefficient values; positive and negative values
indicated transcripts correlated to increased expression in
‘SYS’ and ‘NED’ disease, respectively with intermediate
expression values in the ‘PSA’ disease group.
SEQ ID No Weights
1 −6.08
4 −5.39
6 −4.84
9 −4.66
14 −4.37
15 −4.32
16 −4.27
18 −4.2
19 −4.18
20 −4.1
21 −4.09
915 5.27
916 4.82
917 4.64
920 4.49
922 4.43
928 4.27
929 4.27
931 4.17
935 4.08
936 4.07
TABLE 9
RNA transcripts used to derive 10-RNA metagene values, which
were converted by scaling and normalizing into ‘POP’ scores
depicted in FIG. 5. RNA transcripts were identified using Nearest
Shrunken Centroids algorithm with leave-1-out cross-validation
to distinguish ‘recurren’ (i.e., ‘SYS’) and ‘non-recurrent’
(i.e., ‘PSA’ and ‘NED’) disease from Table 3 RNA transcripts.
Weighting factors were from the test statistic values; positive and
negative values indicated transcripts correlated to increased
expression in ‘recurrent’ and ‘non-recurrent’ disease,
respectively.
Seq ID Weights
3 −5.48
36 −4.93
60 −5.72
63 −4.79
926 4.61
971 4.68
978 5.27
999 4.74
1014 4.86
1022 6.29
TABLE 10
RNA transcripts used to derive 41-RNA metagene values, which
were converted by scaling and normalizing into ‘POP’ scores
depicted in FIG. 6. RNA transcripts were identified using Nearest
Shrunken Centroids algorithm with leave-1-out cross-validation to
distinguish ‘recurrent’ (i.e., ‘SYS’) and ‘non-recurrent’
(i.e., ‘PSA’ and ‘NED’) disease from Table 3 RNA transcripts.
Weighting factors were from the test statistic values; positive and
negative values indicated transcripts correlated to increased
expression in ‘recurrent’ and ‘non-recurrent’ disease,
respectively.
Seq ID Weights
1 −4.1
2 −4.21
3 −5.48
32 −3.87
33 −3.75
36 −4.93
46 −4.14
60 −5.72
63 −4.79
66 −4.02
69 −3.25
88 −4.54
100 −3.63
241 −4.16
265 −3.86
334 −3.36
437 −4.02
920 4.36
925 3.04
934 3.65
945 4.03
947 4.44
954 4.34
971 4.68
978 5.27
999 4.74
1004 4.5
1014 4.86
1022 6.29
1023 4.08
1032 3.49
1080 3.97
1093 4.02
1101 3.55
1164 3.54
1248 3.56
1304 3.14
1311 3.66
1330 3.02
1402 3.45
1425 3.73
Although the invention has been described with reference to certain specific embodiments, various modifications thereof will be apparent to those skilled in the art without departing from the spirit and scope of the invention. All such modifications as would be apparent to one skilled in the art are intended to be included within the scope of the following claims.
