Patents Assigned to The Trustees of the University of Pennsylvania
  • Patent number: 9868990
    Abstract: The present invention relates to the NIPA-1 proteins and nucleic acids encoding the NIPA-1 proteins. The present invention further provides assays for the detection of NIPA-1 polymorphisms and mutations associated with disease states, as well as methods of screening for ligands and modulators of NIPA-1 proteins.
    Type: Grant
    Filed: February 3, 2016
    Date of Patent: January 16, 2018
    Assignees: The Regents of the University of Michigan, The Trustees of the University of Pennsylvania
    Inventors: John K. Fink, Shirley Rainier, Robert D. Nicholls, Jinghua Chai
  • Patent number: 9861622
    Abstract: The present invention provides methods and compositions for treating hyperlipidemia and/or hypercholesterolemia comprising administering to the subject an effective amount of an MTP inhibitor to inhibit hyperlipidemia and/or hypercholesterolemia in said subject, wherein said administration comprises an escalating series of doses of the MTP inhibitor. In some embodiments the method comprises administering at least three step-wise, increasing dosages of the MTP inhibitor to the subject. In some embodiments, the method further comprises the administration of one or more other lipid modifying compounds.
    Type: Grant
    Filed: July 25, 2016
    Date of Patent: January 9, 2018
    Assignee: The Trustees of the University of Pennsylvania
    Inventor: Daniel J. Rader
  • Patent number: 9861474
    Abstract: Cardiac repair prostheses, sets, and methods for implanting in an aorta are disclosed. Cardiac repair prosthesis sets can include a radially expandable support supporting a unidirectional valve that is configured for implantation into the aortic valve region of a patient and a second radially expandable support for a substantially blood impervious stent having a size and shape for implantation into the ascending aorta of said patient where the unidirectional valve and stent are configured for integration within the patient by at least one joining element. Cardiac repair prostheses can include a radially expandable support supporting a unidirectional valve configured for implantation into the aortic valve region of a patient and a second radially expandable support for a substantially blood impervious stent having a size and shape for implantation into the ascending aorta of said patient where the unidirectional valve and stent are joined by at least one joining element.
    Type: Grant
    Filed: July 17, 2014
    Date of Patent: January 9, 2018
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: Bartosz Rylski, Joseph Bavaria, Rita Carrie Milewski
  • Patent number: 9865465
    Abstract: Nanocrystal thin film devices and methods for fabricating nanocrystal thin film devices are disclosed. The nanocrystal thin films are diffused with a dopant such as Indium, Potassium, Tin, etc. to reduce surface states. The thin film devices may be exposed to air during a portion of the fabrication. This enables fabrication of nanocrystal-based devices using a wider range of techniques such as photolithography and photolithographic patterning in an air environment.
    Type: Grant
    Filed: January 17, 2014
    Date of Patent: January 9, 2018
    Assignee: The Trustees Of The University Of Pennsylvania
    Inventors: Cherie R. Kagan, David K. Kim, Ji-Hyuk Choi, Yuming Lai
  • Patent number: 9855357
    Abstract: A device for rapidly sanitizing a surface is described. The device has an enclosure having an opening adapted to insert a surface, and an interior; a liquid nitric oxide solution applicator; and an absorbent material. The liquid nitric oxide solution applicator is in fluid communication with the interior of the enclosure and is adapted to apply liquid nitric oxide solution onto the surface when the surface is positioned within the enclosure. A method of rapidly sanitizing a surface is described. The devices and methods provided herein may be implemented to sanitize the surface of any body part or item that may be placed within the device. An infectious agent on the surface may be killed; i.e., the surface is disinfected. Non-limiting applications of the devices and methods include preventing nosocomial infections or food contamination, sanitizing household items, and implementing sanitizing procedures to comply with FDA Good Manufacturing Practices.
    Type: Grant
    Filed: March 5, 2014
    Date of Patent: January 2, 2018
    Assignee: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
    Inventor: Paul H. Axelsen
  • Patent number: 9856275
    Abstract: The invention is directed to the preparation of fluorinated compounds and their use in organic synthesis. In particular, the invention is directed to methods of reacting compounds of structure with Rf—CH?N2 or (CF3)2C?N2 to form a perfluoroalkylate or -arylated compounds, and products derived from these reactions, where X, YB, and Rf are described herein.
    Type: Grant
    Filed: February 12, 2014
    Date of Patent: January 2, 2018
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: Gary Alan Molander, Oana Andreea Argintaru
  • Publication number: 20170369777
    Abstract: Monodisperse particles having: a single pure crystalline phase of a rare earth-containing lattice, a uniform three-dimensional size, and a uniform polyhedral morphology are disclosed. Due to their uniform size and shape, the monodisperse particles self assemble into superlattices. The particles may be luminescent particles such as down-converting phosphor particles and up-converting phosphors. The monodisperse particles of the invention have a rare earth-containing lattice which in one embodiment may be an yttrium-containing lattice or in another may be a lanthanide-containing lattice. The monodisperse particles may have different optical properties based on their composition, their size, and/or their morphology (or shape).
    Type: Application
    Filed: August 16, 2017
    Publication date: December 28, 2017
    Applicants: INTELLIGENT MATERIAL SOLUTIONS, INC., THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
    Inventors: Joshua E. COLLINS, Howard Y. BELL, Xingchen YE, Christopher Bruce MURRAY
  • Patent number: 9850261
    Abstract: Compositions and methods using silicon-based cross-coupling agents in the formation of carbon-carbon and carbon-nitrogen bonds are described.
    Type: Grant
    Filed: July 16, 2015
    Date of Patent: December 26, 2017
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: Adam T. Hoye, Won-Suk Kim, Dionicio Martinez-Solorio, Amos B. Smith, III, Rongbiao Tong, Minh Huu Nguyen, Luis Sanchez, Bruno Nicolas Melillo
  • Patent number: 9851425
    Abstract: A technique and associated imaging system is provided that selectively acquires the myelin water signal by utilizing a multiple inversion RF pulses to suppress a range of long T1 components including those from axonal and extracellular water. This leaves the myelin water, which has been suggested to have short T1, as the primary source of the image. After long T1 suppression, the resulting image is dominated by short T2 in the range of the myelin water (T2*<20 ms at 3 T). This result confirms that the short T1 component has short T2* and, therefore, the resulting image is a myelin water image.
    Type: Grant
    Filed: November 26, 2013
    Date of Patent: December 26, 2017
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: Jongho Lee, Sehong Oh
  • Patent number: 9850469
    Abstract: The present disclosure pertains to the field peptide stapling and/or macrocyclization, where a structural motif is used to improve the properties of amino acid sequences (e.g. protease resistance, cellular penetration, biological activity). Also within the scope of the disclosure are methods for unstapling the S,S-tetrazine-containing amino acid sequence. The disclosure is also directed to methods for the reductive removal of thiocyanates from an amino acid sequence with cysteine to recycle back to the native amino acid sequence.
    Type: Grant
    Filed: March 17, 2015
    Date of Patent: December 26, 2017
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: Amos B. Smith, III, Stephen Brown
  • Patent number: 9845480
    Abstract: The present invention includes methods for effecting phenotype conversion in a cell by transfecting the cell with phenotype-converting nucleic acid. Expression of the nucleic acids results in a phenotype conversion in the transfected cell. Preferably the phenotype-converting nucleic acid is a transcriptome, and more preferably an mRNA transcriptome.
    Type: Grant
    Filed: October 12, 2015
    Date of Patent: December 19, 2017
    Assignee: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
    Inventors: James Eberwine, Jai-Yoon Sul, Tae Kyung Kim, Vickas Patel
  • Patent number: 9846157
    Abstract: A repeatable method for detecting circulating tumor cells in vitro is provided. The method involves combining a test sample from a patient suspected of having circulating tumor cells, and a non-lytic adenoviral system, and culture media for the cells. The adenoviral system utilizes (i) a first replication-defective adenoviral particle in which an expression cassette is packaged, said expression cassette comprising an adenoviral 5? and 3? ITRs and a tumor-specific promoter; and (ii) a coding sequence for a reporter protein which is expressed in the presence of circulating tumor cells, and an adenoviral 3? ITR. The test sample and the non-lytic adenoviral system are incubated for a sufficient time to permit expression of the reporter protein, and measuring reporter protein expression in the test samples, whereby presence of reporter expression indicates the presence of circulating tumor cells in the sample.
    Type: Grant
    Filed: March 14, 2013
    Date of Patent: December 19, 2017
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: Stephen M. Hahn, Jay F. Dorsey, Gary D. Kao, Emigdio Reyes
  • Publication number: 20170355778
    Abstract: Methods of treating an individual who has an erbB protein mediated tumor is disclosed. Methods of preventing erbB protein mediated tumors in an individual are disclosed. The methods comprise administering to the individual a nucleic acid molecule that encodes a protein that dimerizes with an erbB protein and that is deficient in tyrosine kinase activity. Composition that comprise such nucleic acid molecules including pharmaceutical compositions are disclosed.
    Type: Application
    Filed: February 1, 2017
    Publication date: December 14, 2017
    Applicant: The Trustees of the University of Pennsylvania
    Inventors: Mark I. GREENE, Donald M. O'ROURKE, Ramachandran MURALI, Byeong Woo PARK
  • Patent number: 9839367
    Abstract: An implantable sensor array incorporates active electronic elements to greatly increase the number of sensors and their density that can be simultaneously recorded and activated. The sensors can be of various configurations and types, for example: optical, chemical, temperature, pressure or other sensors including effectors for applying signals to surrounding tissues. The sensors/effectors are arranged on a flexible and stretchable substrate with incorporated active components that allow the effective size, configuration, number and pattern of sensors/effectors to be dynamically changed, as needed, through a wired or wireless means of communication. Active processing allows many channels to be combined either through analog or digital means such that the number of wires exiting the array can be substantially reduced compared to the number of sensors/effectors on the array.
    Type: Grant
    Filed: July 22, 2016
    Date of Patent: December 12, 2017
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: Brian Litt, Jonathan Viventi
  • Patent number: 9834610
    Abstract: The present invention provides fusion proteins that act on the glucocorticoid-induced TNFR family-related gene (GITR) and OX40 signaling pathway. In certain aspects, the proteins of the invention are useful in modulating both regulatory T (Treg) cells and effector T (Teff) cells.
    Type: Grant
    Filed: January 31, 2014
    Date of Patent: December 5, 2017
    Assignees: Thomas Jefferson University, The Trustees of the University of Pennsylvania
    Inventor: Mark L. Tykocinski
  • Patent number: 9827212
    Abstract: The present invention provides methods for dilating the bronchi or bronchioles and relaxing a pulmonary smooth muscle in a subject by treating the subject with a pharmaceutical composition, which includes a Histone deacetylase (HDAC) inhibitor. The ability to dilate the bronchi or bronchioles and relax a pulmonary smooth muscle according to the methods of the invention allows treating, alleviating, or inhibiting bronchoconstrictive diseases or disorders and symptoms associated or derived from bronchoconstrictive diseases.
    Type: Grant
    Filed: March 18, 2010
    Date of Patent: November 28, 2017
    Assignee: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
    Inventors: Jonathan A. Epstein, Reynold Panettieri
  • Patent number: 9827321
    Abstract: The present inventions are directed to shear-thinning and stabilizing hydrogels, especially for use in drug delivery and therapy. Various embodiments provide settable, shear-thinning hydrogels, each hydrogel comprising a hydrophilic polymer network, said hydrophilic polymer network comprising non-covalent crosslinks and at least one set of chemical moieties being capable of participating in at least one chemical covalent cross-linking reaction. In certain embodiments, these settable shear-thinning hydrogels are triggerable to cross-link by the application of a stimulus.
    Type: Grant
    Filed: July 30, 2013
    Date of Patent: November 28, 2017
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: Jason A. Burdick, Christopher B. Rodell
  • Publication number: 20170334890
    Abstract: Methods for improving mitochondrial function, decreasing iron accumulation, and/or decreasing oxidative stress by exposing cells or treating a subject to compounds or compositions of the general formula are described that are beneficial in treating, for example, diseases and conditions such as Friedreich's ataxia, normal aging, and various neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease. Furthermore, such compounds are useful as probes for identifying defects in mitochondrial metabolism, mitochondrial iron accumulation, cellular stress among other mitochondrial diseases and helping to identify compounds active in overcoming such defects.
    Type: Application
    Filed: June 2, 2017
    Publication date: November 23, 2017
    Applicant: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
    Inventors: Robert B. Wilson, Maria Grazia Cotticelli, Phillip A. Benedetti, Amos SMITH, Jason E. Melvin, Donna M. Huryn
  • Publication number: 20170335281
    Abstract: The invention provides compositions and methods for treating diseases associated with expression of a cancer associated antigen as described herein. The invention also relates to chimeric antigen receptor (CAR) specific to a cancer associated antigen as described herein, vectors encoding the same, and recombinant T cells comprising the CARs of the present invention. The invention also includes methods of administering a genetically modified T cell expressing a CAR that comprises an antigen binding domain that binds to a cancer associated antigen as described herein.
    Type: Application
    Filed: March 13, 2015
    Publication date: November 23, 2017
    Applicants: Novartis AG, The Trustees of the University of Pennsylvania
    Inventors: Andreas Loew, Michael C. Milone, Daniel J. Powell, Jr., Yangbing Zhao
  • Patent number: 9821031
    Abstract: This invention relates to methods of treating and ameliorating congenital and neonatal hyperinsulinism and post-prandial hypoglycemia, comprising the step of administering an antagonist of the Glucagon-Like Peptide-1 (GLP-I) receptor, e.g. a GLP-I fragment or analogue thereof.
    Type: Grant
    Filed: January 8, 2008
    Date of Patent: November 21, 2017
    Assignees: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, CHILDREN'S HOSPITAL OF PHILADELPHIA
    Inventors: Doris Stoffers, Diva D. De Leon, Charles Stanley