Patents Assigned to The Trustees of the University of Pennsylvania
  • Patent number: 9943590
    Abstract: This invention relates to methods of using a Listeria vaccine vector to induce a Th1 immune response in subjects having persistent Th2 immune response profiles.
    Type: Grant
    Filed: October 7, 2015
    Date of Patent: April 17, 2018
    Assignees: The Trustees of the University of Pennsylvania, University of Georgia Research Foundation, Inc.
    Inventors: Donald A. Harn, Jr., Yvonne Paterson, Lisa McEwen
  • Patent number: 9942683
    Abstract: Methods and systems for sound propagation and perception for autonomous agents in dynamic environments are described. Adaptive discretization of continuous sound signals allows one to obtain a minimal, yet sufficient sound packet representation (SPR) for human-like perception, and a hierarchical clustering scheme to facilitate approximate perception. Planar sound propagation of discretized sound signals exhibit acoustic properties such as attenuation, reflection, refraction, and diffraction, as well as multiple convoluted sound signals. Agent-based sound perceptions using hierarchical clustering analysis that accommodates natural sound degradation due to audio distortion facilitate approximate human-like perception.
    Type: Grant
    Filed: July 16, 2014
    Date of Patent: April 10, 2018
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: Norman I. Badler, Pengfei Huang, Mubbasir Kapadia
  • Patent number: 9937205
    Abstract: The present invention provides compositions and methods for inhibiting one or more diacylglycerol kinase (DGK) isoform in a cell in order to enhance the cytolytic activity of the cell. In one embodiment, the cells may be used in adoptive T cell transfer. For example, in some embodiments, the cell is modified to express a chimeric antigen receptor (CAR). Inhibition of DGK in T cells used in adoptive T cell transfer increases cytolytic activity of the T cells and thus may be used in the treatment of a variety of conditions, including cancer, infection, and immune disorders.
    Type: Grant
    Filed: September 4, 2013
    Date of Patent: April 10, 2018
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: Steven M. Albelda, Liang-Chuan Wang, Gary Koretzky, Matthew Riese
  • Publication number: 20180085168
    Abstract: A method comprises receiving one or more plan parameters of a first radiation treatment plan for a first patient and one or more passing rate data for the first treatment plan; generating a predictive model for passing rate data from the plan parameters of the first radiation treatment plan and the passing rate data for the first treatment plan; receiving one or more plan parameters of a second radiation treatment plan for a second patient; and applying the predictive model to the plan parameters of the second radiation treatment to generate one or more predicted passing rate data for the plan parameters for the second patient.
    Type: Application
    Filed: March 30, 2016
    Publication date: March 29, 2018
    Applicant: The Trustees of the University of Pennsylvania
    Inventors: Gilmer VALDES, Timothy SOLBERG, Ryan SCHEUERMANN, Marc BELLERIVE, C.Y. HUNG, Arthur OLSZANSKI
  • Patent number: 9926588
    Abstract: This invention provides methods for treating diseases associated with elevated p38 mitogen-activated protein kinase activity. Moreover, the invention provides methods for testing a candidate compound for a p38 mitogen-activated protein kinase modifying activity by calculating the level of relocalization of an SMN complex component from the cytoplasm to the nucleus of a cell. Additionally, the invention provides a kit and a system for calculating the same.
    Type: Grant
    Filed: June 4, 2008
    Date of Patent: March 27, 2018
    Assignee: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
    Inventors: Gideon Dreyfuss, Mumtaz Kasim
  • Patent number: 9930777
    Abstract: The present invention provides methods for fabricating graphene workpieces. The present invention also provides for products produced by the methods of the present invention and for apparatuses used to perform the methods of the present invention.
    Type: Grant
    Filed: April 23, 2015
    Date of Patent: March 27, 2018
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: Alan T. Johnson, Rajatesh R. Gudibande, Zhengqing John Qi
  • Patent number: 9925268
    Abstract: The present invention provides implants comprising a therapeutic drug and a polymer containing polylactic acid (PLA) and optionally polyglycolic acid (PGA). The present invention also provides methods of maintaining a therapeutic level of a drug in a subject, releasing a therapeutic drug at a substantially linear rate, and treating schizophrenia and other diseases and disorders, utilizing implants of the present invention.
    Type: Grant
    Filed: June 19, 2017
    Date of Patent: March 27, 2018
    Assignee: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
    Inventors: Steven Siegel, Karen Winey
  • Publication number: 20180078682
    Abstract: Orthopedic and dental implants coated with an antibacterial coating and methods of making and using, are described herein. The implant can be coated with a hydrophobic, polycationic antibacterial polymer. The polymer can be covalently or non-covalently associated with the surface; however, in particular embodiments, the polymer is non-covalently associated with the surface. As shown in the examples below, clinical observations, digital radiography, and a battery of well-accepted ex vivo analytical methods show that the presence of a hydrophobic polycationic polymer coating, such as N,N-dodecyl,methyl-PEI coating on the surface of a metal implant, was effective in eliminating the clinical signs of infection in vivo in a large animal infection model. Moreover, the coated plates supported bone healing, and in fact decreased healing times, even in the presence of significant bacterial contamination compared to a control.
    Type: Application
    Filed: November 16, 2017
    Publication date: March 22, 2018
    Applicant: The Trustees of the University of Pennsylvania
    Inventors: Thomas P. Schaer, Suzanne Stewart, Alexander M. Klibanov
  • Patent number: 9919038
    Abstract: The present invention provides recombinant Listeria strains comprising an angiogenic factor, recombinant polypeptides comprising an angiogenic factor operatively linked to a polypeptide comprising a PEST-like sequence, recombinant nucleotide molecules encoding same, related vaccines, and immunogenic and therapeutic methods utilizing same.
    Type: Grant
    Filed: January 15, 2016
    Date of Patent: March 20, 2018
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: Matthew Seavey, Yvonne Paterson, Paulo Maciag, Duane Sewell
  • Patent number: 9919054
    Abstract: The invention relates to compositions comprising (i) biocompatible hydrogel and (ii) one or more therapeutic agents contained within said hydrogel; wherein the hydrogel is cross-linked utilizing a cross-linker comprising a peptide sequence that is capable of being degraded by an enzyme; the therapeutic agent being effective as a treatment of a condition related to the presence of the enzyme.
    Type: Grant
    Filed: May 22, 2017
    Date of Patent: March 20, 2018
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: Jason Alan Burdick, Robert C. Gorman, Joseph H. Gorman, III, Brendan Patrick Purcell
  • Patent number: 9920295
    Abstract: The present invention relates to a bioreactor apparatus, and methods of use, for the isolation of rare blood cells, including hematopoietic stem cells and megakaryocytes. The apparatus includes a soft substrate and an anti-contractility agent, thereby providing a soft microenvironment to cultured cells. The apparatus of the invention is permissive for the survival of non-dividing cells while dividing cells are eliminated. This unique property allows for the simple isolation of rare blood cells without the use of costly equipment and antibodies.
    Type: Grant
    Filed: February 21, 2013
    Date of Patent: March 20, 2018
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: Dennis E. Discher, Jae-Won Shin
  • Publication number: 20180071233
    Abstract: The present invention provides methods for dilating the bronchi or bronchioles and relaxing a pulmonary smooth muscle in a subject by treating the subject with a pharmaceutical composition, which includes a Histone deacetylase (HDAC) inhibitor. The ability to dilate the bronchi or bronchioles and relax a pulmonary smooth muscle according to the methods of the invention allows treating, alleviating, or inhibiting bronchoconstrictive diseases or disorders and symptoms associated or derived from bronchoconstrictive diseases.
    Type: Application
    Filed: November 21, 2017
    Publication date: March 15, 2018
    Applicant: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
    Inventors: Jonathan A. EPSTEIN, Reynold PANETTIERI
  • Patent number: 9914535
    Abstract: Technology for achieving the behavior and benefits of traditional cyclic control in one rotor may be implemented with a simple under-actuated passive mechanism. An air vehicle employing the disclosed technology maintains lifting thrust by regulating the average rotor speed and generates control moments through coordinated pulsing of the motor torque. Rapid pulsing of the motor torque induces oscillations in propeller angle of attack, and so causes “cyclic control” without requiring the traditional auxiliary actuators and linkages. The MAV propulsion system is capable of using a minimum number of actuators in dual roles of thrust and moment objectives.
    Type: Grant
    Filed: March 14, 2014
    Date of Patent: March 13, 2018
    Assignee: The Trustees of the University of Pennsylvania
    Inventor: James J. Paulos
  • Patent number: 9913879
    Abstract: The inventive subject matter relates to novel methods for modulating an immune response in an animal, which comprises administering to said animal an effective amount of an agent that increases IL-27R/WSX-1 activity. Further, the inventive subject matter relates to pharmaceutical compositions comprising an effective amount of an agent that increases IL-27R/WSX-1 activity.
    Type: Grant
    Filed: April 18, 2014
    Date of Patent: March 13, 2018
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: Christopher A. Hunter, Alejandro Villarino
  • Publication number: 20180057603
    Abstract: The present invention provides a fusion proteins comprising (a) a first stretch of consecutive amino acids, the sequence of which is the sequence of an anti-p185her2/neu polypeptide or an anti-EGFR polypeptide; (b) a second stretch of consecutive amino acids, the sequence of which is the sequence of a polypeptide capable of binding at least one polypeptide other than p185her2/neu or EGFR; and (c) a third stretch of consecutive amino acids, the sequence of which comprises the sequence of a biologically active portion of interferon-gamma (IFN?), wherein (b) is located at the carboxy-terminal end of (a), and (c) is located at the carboxy-terminal end of (b). The present invention provides methods and compositions treating or preventing cancer and for sensitizing cancer cells to radiation or a chemotherapeutic agent, which comprises administering i) an anti-p185her2/neu antibody, an anti-EGFR antibody or an erbB kinase inhibitor and interferon-gamma (IFN?); or ii) a fusion protein of the invention.
    Type: Application
    Filed: February 9, 2016
    Publication date: March 1, 2018
    Applicant: The Trustees of the University of Pennsylvania
    Inventors: Mark Greene, Hongtao Zhang, Hiromichi Tsuchiya, Yasuhiro Nagai, Lian Lam, Aaron Runkle, Jeffrey Drebin, Mei Qing Ji
  • Patent number: 9905760
    Abstract: Disclosed herein are resistive switching devices having, e.g., an amorphous layer comprised of an insulating aluminum-based or silicon-based material and a conducting material. The amorphous layer may be disposed between two or more electrodes and be capable of switching between at least two resistance states. Circuits and memory devices including resistive switching devices are also disclosed, and a composition of matter involving an insulating aluminum-based or an silicon-based material and a conducting material. Also disclosed herein are methods for switching the resistance of an amorphous material.
    Type: Grant
    Filed: June 14, 2016
    Date of Patent: February 27, 2018
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: I-Wei Chen, Xiang Yang
  • Publication number: 20180050095
    Abstract: This invention relates to methods of treating and ameliorating congenital and neonatal hyperinsulinism and post-prandial hypoglycemia, comprising the step of administering an antagonist of the Glucagon-Like Peptide-1 (GLP-1) receptor, e.g. a GLP-1 fragment or analogue thereof.
    Type: Application
    Filed: March 8, 2017
    Publication date: February 22, 2018
    Applicants: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, CHILDREN'S HOSPITAL OF PHILADELPHIA
    Inventors: Doris Stoffers, Diva D. DE LEON, Charles STANLEY
  • Publication number: 20180051243
    Abstract: A fluid transfer system includes a transfer carousel capable of rotational and/or translational movement; at least one holding vessel (e.g. syringe) having a plunger, wherein the syringe is connected to the transfer carousel such that the movement of the transfer carousel results in movement of the syringe and wherein the syringe is capable of translational movement relative to the transfer carousel; a drive motor connected to the syringe that is capable of controlling the position of the plunger; and a peripheral module comprising at least one vessel that is capable of containing a fluid, wherein the vessel has an opening that can be mated with the syringe to allow fluid transfer between the vessel and the syringe. Methods for transferring a fluid are also disclosed.
    Type: Application
    Filed: March 11, 2016
    Publication date: February 22, 2018
    Applicant: The Trustees of the University of Pennsylvania
    Inventors: Michael HOGAN, Orkan M. TELHAN, Karen HOGAN
  • Patent number: 9895351
    Abstract: Provided are compositions for inhibiting a biological activity of an aldo-keto reductase family 1, member C3 (AKR1C3) polypeptide. In some embodiments, the compositions are indomethacin derivatives that are AKR1C3-specific inhibitors. Also provided are methods for producing disclosed indomethacin derivatives that substantially lack cyclooxygenase inhibitory activity but that have AKR1C3 inhibitory activity, methods for inhibiting AKR1C3 polypeptide biological activities, and methods for treating prostate tumors in subjects.
    Type: Grant
    Filed: April 19, 2016
    Date of Patent: February 20, 2018
    Assignees: Vanderbilt University, The Trustees of the University of Pennsylvania
    Inventors: Lawrence J. Marnett, Andy J. Liedtke, Trevor M. Penning, Adegoke O. Adeniji, Michael C. Byrns
  • Patent number: 9895399
    Abstract: The invention relates to methods and compositions for maintaining the pro-regenerative capacity of distal nerve segments following nerve injury.
    Type: Grant
    Filed: January 31, 2014
    Date of Patent: February 20, 2018
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: Douglas H. Smith, Kacy D. Cullen, John A. Wolf