Patents Assigned to The Trustees of the University of Pennsylvania
  • Publication number: 20180171294
    Abstract: A method of creating a microenvironment for culture expansion of T cells. The expanded T cells can be used for a variety of therapeutic and research purposes.
    Type: Application
    Filed: February 28, 2016
    Publication date: June 21, 2018
    Applicant: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
    Inventors: Brian J. Czerniecki, Lea Lowenfeld
  • Publication number: 20180169222
    Abstract: The presently disclosed subject matter relates to methods and compositions relating to immunostimulatory RNA motifs that act as adjuvants and/or immunostimulatory agents to enhance host immune responses.
    Type: Application
    Filed: April 29, 2016
    Publication date: June 21, 2018
    Applicant: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
    Inventor: Carolina B. Lopez
  • Publication number: 20180174851
    Abstract: The disclosed subject matter provides thin films including a metal silicide and methods for forming such films. The disclosed subject matter can provide techniques for tailoring the electronic structure of metal thin films to produce desirable properties. In example embodiments, the metal silicide can comprise a platinum silicide, such as for example, PtSi, Pt2Si, or Pt3Si. For example, the disclosed subject matter provides methods which include identifying a desired phase of a metal silicide, providing a substrate, depositing at least two film layers on the substrate which include a first layer including amorphous silicon and a second layer including metal contacting the first layer, and annealing the two film layers to form a metal silicide. Methods can be at least one of a source-limited method and a kinetically-limited method. The film layers can be deposited on the substrate using techniques known in the art including, for example, sputter depositing.
    Type: Application
    Filed: February 7, 2018
    Publication date: June 21, 2018
    Applicant: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
    Inventors: Robert W. Carpick, Frank Streller, Rahul Agarwal, Filippo Mangolini
  • Publication number: 20180175319
    Abstract: A method for engineering a line shape of emission spectrum of an organic emissive material in an electroluminescent device is disclosed in which a layer of plasmonic metallic nanostructures having a localized surface plasmonic resonance (LSPR) is provided in proximity to the emissive layer and the layer of plasmonic metallic nanostructures is greater than 2 nm but less than 100 nm from the emissive layer and the LSPR of the plasmonic metallic nanostructures matches the emission wavelength of the organic emissive material. An electroluminescent device incorporating the plasmonic metallic nanostructures is also disclosed.
    Type: Application
    Filed: December 15, 2016
    Publication date: June 21, 2018
    Applicants: Universal Display Corporation, THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
    Inventors: Nicholas J. THOMPSON, Cherie R. KAGAN, Christopher B. MURRAY
  • Publication number: 20180169024
    Abstract: Embodiments of the present invention relate to mechanically-activated microcapsules (MAMCs) for controlled drug-delivery, wherein the MAMCs release one or more active ingredients in response to mechanical stimuli in a subject's body. The MAMCs provide a platform for stimulating biological regeneration, biological repair, modifying disease, and/or controlling disease in mechanically-loaded musculoskeletal tissues.
    Type: Application
    Filed: June 1, 2016
    Publication date: June 21, 2018
    Applicant: The Trustees Of The University Of Pennsylvania
    Inventors: Daeyeon Lee, Robert L. Mauck, George R. Dodge, Fuquan Tu, Bhavana Mohanraj
  • Patent number: 9999779
    Abstract: Methods and apparatus are provided for applying low magnetic fields (<400 G) to mammalian cells, tissues and organs for protection from the damaging effects of ionizing radiation and other oxygen dependent injuries that involve the radical pair mechanism. The magnetic fields are generated by fixed magnets or active magnets and used to enhance the survival of healthy cells during radiation treatment for cancer, to protect workers from radiation within nuclear power plants, to protect astronauts from radiation during long space voyages, to increase working time in exposed environments, to provide a safe room in hazardous locations, and to protect normal tissue during radiation treatment and in medical imaging modalities that use ionizing radiation (X-ray, CT, mammography). The method described herein may also be used to mitigate the damaging effects of reperfusion, stroke, oxygen toxicity, inflammation, autoimmune disease, and the like by applying protective magnetic fields.
    Type: Grant
    Filed: October 29, 2014
    Date of Patent: June 19, 2018
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: Lawrence Dougherty, James J. Pilla, Keith A. Cengel, Alireza Kassaee
  • Patent number: 9999756
    Abstract: Systems and methods for delivering a gaseous contrast agent to the lungs of a subject.
    Type: Grant
    Filed: October 29, 2014
    Date of Patent: June 19, 2018
    Assignee: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
    Inventors: Kiarash Emami, Stephen J. Kadlecek, Rahim R. Rizi, Masaru Ishii, Hooman Hamedani
  • Publication number: 20180162818
    Abstract: Described herein is an alpha-emitting radionuclide, 211At, which has been incorporated into a selective sigma-2 ligand moiety to provide cytotoxic capabilities to a chemical compound. As described herein, a compound of formula (I), wherein R1-R4, m, and n are defined herein, was prepared and utilized in in vitro and in vivo tumor targeting of alpha-emitting sigma-2 ligand in a breast cancer model. In one embodiment, the compound is 5-(211At)—N-(4-(6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)butyl)-2,3-dimethoxybenzamide.
    Type: Application
    Filed: April 26, 2016
    Publication date: June 14, 2018
    Applicant: The Trustees of The University of Pennsylvania
    Inventors: Daniel A. PRYMA, Brian p. LIEBERMAN, Mehran MAKVANDI, Robert H. MACH
  • Patent number: 9994619
    Abstract: Provided herein are nucleic acid sequences that encode novel consensus amino acid sequences of herpes virus antigens, as well as genetic constructs/vectors and vaccines expressing the sequences. Also provide herein are methods for generating an immune response against herpes virus using the vaccines that are provided.
    Type: Grant
    Filed: January 20, 2016
    Date of Patent: June 12, 2018
    Assignee: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
    Inventors: David B Weiner, Devon Shedlock
  • Patent number: 9993545
    Abstract: The present invention relates to synthetic, consensus foot-and-mouth disease virus (FMDV) immunogenic proteins and nucleic acid molecule encoding such proteins, to vaccines against FMDV, to methods for inducing immune responses against FMVD, to methods for distinguishing between individuals infected with FMDV versus those vaccinated against FMDV, and methods of prophylactically and/or therapeutically immunizing individuals against FMDV.
    Type: Grant
    Filed: March 17, 2014
    Date of Patent: June 12, 2018
    Assignees: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, INOVIO PHARMACEUTICALS, INC.
    Inventors: David B. Weiner, Jian Yan, Karuppiah Muthumani, Niranjan Y. Sardesai
  • Patent number: 9994625
    Abstract: Protein misfolding underpins several fatal neurodegenerative disorders. The application is directed to recombinant Hsp104 proteins comprising missense mutations aimed at correcting these events, and methods for expressing and delivering same.
    Type: Grant
    Filed: February 25, 2015
    Date of Patent: June 12, 2018
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: James Shorter, Meredith E. Jackrel
  • Patent number: 9994629
    Abstract: Disclosed herein is a composition including a recombinant nucleic acid sequence that encodes an antibody. Also disclosed herein is a method of generating a synthetic antibody in a subject by administering the composition to the subject. The disclosure also provides a method of preventing and/or treating disease in a subject using said composition and method of generation.
    Type: Grant
    Filed: December 13, 2013
    Date of Patent: June 12, 2018
    Assignee: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
    Inventors: David B. Weiner, Karuppiah Muthumani, Niranjan Sardesai, Seleeke Flingai
  • Patent number: 9994818
    Abstract: The invention includes compositions and methods for generating and expanding therapeutic Th17 cells. The invention includes contacting T cells with a composition comprising a first agent that is capable of providing a primary activation signal to T cells and a second agent that is capable of activating ICOS on T cells in the presence of Th-17 polarizing agents.
    Type: Grant
    Filed: August 11, 2015
    Date of Patent: June 12, 2018
    Assignee: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
    Inventors: James L. Riley, Chrystal Paulos, Carl H. June, Bruce L. Levine
  • Patent number: 9990856
    Abstract: Systems and methods for training an operator of a robotic surgery system are disclosed. One such method includes enabling the operator to perform a test procedure, recording vibrations of a surgical tool of the robotic surgery system during the test procedure, and generating a score for the operator based at least in part on the recorded vibrations of the surgical tool.
    Type: Grant
    Filed: March 15, 2013
    Date of Patent: June 5, 2018
    Assignee: The Trustees Of The University Of Pennsylvania
    Inventors: Katherine J. Kuchenbecker, Will McMahan, Ernest D. Gomez, Karlin Bark
  • Patent number: 9987321
    Abstract: The invention provides compositions and methods for treating neurological disorders and viral infection using whole-grain flaxseed, flaxseed lignans such as Secoisolariciresinol diglucoside (SDG), human lignans metabolized from flaxseed such as Enterodiol (ED) or Enterolactone (EL), and synthetic flaxseed lignan analogs.
    Type: Grant
    Filed: November 19, 2013
    Date of Patent: June 5, 2018
    Assignee: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
    Inventors: Melpo Christofidou-Solomidou, Kelly Jordan-Sciutto
  • Patent number: 9987347
    Abstract: An aspect of the present invention is related to nucleic acid constructs capable of expressing a polypeptide, such as a consensus dengue prME that elicits an immune response in a mammal against more than one subtype of dengue virus, and methods of use thereof. Additionally, there are DNA plasmid vaccines capable of generating in a mammal an immune response against a plurality of dengue virus subtypes, comprising a DNA plasmid and a pharmaceutically acceptable excipient, and methods of use thereof. The DNA plasmid is capable of expressing a consensus dengue antigen in a cell of the mammal in a quantity effective to elicit an immune response in the mammal that is cross reactive against all 4 dengue subtypes.
    Type: Grant
    Filed: March 14, 2014
    Date of Patent: June 5, 2018
    Assignees: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, INOVIO PHARMACEUTICALS, INC.
    Inventors: David B. Weiner, Jian Yan, Niranjan Sardesai
  • Patent number: 9981024
    Abstract: The present invention provides recombinant Listeria strains comprising an angiogenic factor, recombinant polypeptides comprising an angiogenic factor operatively linked to a polypeptide comprising a PEST-like sequence, recombinant nucleotide molecules encoding same, related vaccines, and immunogenic and therapeutic methods utilizing same.
    Type: Grant
    Filed: August 1, 2016
    Date of Patent: May 29, 2018
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: Matthew Seavey, Yvonne Paterson, Paulo Maciag, Duane Sewell
  • Patent number: 9982256
    Abstract: This invention provides expression vectors for a ribonucleic acid (RNA) molecule comprising a double-stranded region of random sequence, sets and libraries of same, methods of generating same, and methods for identifying an RNA therapeutic or RNA molecule that has an ability to affect a biological parameter, for identifying a drug target for a disease or disorder of interest, and for identifying a variant of an RNA molecule that has an altered ability to affect a biological parameter of interest.
    Type: Grant
    Filed: October 19, 2015
    Date of Patent: May 29, 2018
    Assignee: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
    Inventors: Robert B. Wilson, Yongping Wang
  • Patent number: 9984283
    Abstract: Methods, systems, and computer readable media for automated detection of abnormalities in medical images are disclosed. According to a method for automated abnormality detection, the method includes receiving a target image. The method also includes deformably registering to the target image or to a common template a subset of normative images from a plurality of normative images, wherein the subset of normative images is associated with a normal variation of an anatomical feature. The method further includes defining a dictionary using the subset of normative images. The method also includes decomposing, using sparse decomposition and the dictionary, the target image. The method further includes classifying one or more voxels of the target image as normal or abnormal based on results of the sparse decomposition.
    Type: Grant
    Filed: February 16, 2016
    Date of Patent: May 29, 2018
    Assignee: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
    Inventors: Christos Davatzikos, Ke Zeng, Ali Guray Erus
  • Patent number: 9981036
    Abstract: Nucleic acid molecules and compositions comprising: a nucleic acid sequence that encodes IL-12 p35 subunit or a functional fragment thereof and/or a nucleic acid sequence that encodes IL 12 p40 subunit or a functional fragment thereof, are disclosed. The nucleic acid molecules and compositions further comprising a nucleic acid sequence that encodes an immunogen are also disclosed. Method of modulating immune response and methods of inducing an immune response against an immunogen are disclosed. Therapeutic and prophylactic vaccination methods are also disclosed.
    Type: Grant
    Filed: February 26, 2016
    Date of Patent: May 29, 2018
    Assignee: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
    Inventors: David B. Weiner, Matthew P. Morrow, Jian Yan