Patents Assigned to The Trustees of the University of Pennsylvania
  • Publication number: 20250144243
    Abstract: Provided herein are novel AAV capsids and recombinant AAV vectors comprising the same. In certain embodiment, vectors comprising a novel AAV capsid show improved transduction of cardiac tissue and/or reduced targeting of liver tissue compared to a prior art AAV capsid.
    Type: Application
    Filed: January 24, 2023
    Publication date: May 8, 2025
    Applicant: The Trustees of the University of Pennsylvania
    Inventors: Jacob Hoffman, Joshua Joyner Sims
  • Patent number: 12291707
    Abstract: The present disclosure provides gene edited modified immune cells or precursors thereof (e.g., gene edited modified T cells) comprising an exogenous T cell receptor (TCR) and/or a chimeric antigen receptor (CAR) having specificity for a target antigen, and an insertion and/or deletion in one or more endogenous gene loci, wherein the endogenous gene loci encode regulators of T cell function, thereby resulting in immune cells having enhanced function. Compositions and methods of treatment are also provided. The present invention provides methods of screening for TCR- or CAR-T cells with enhanced immune function (e.g., T cell efficacy, T cell memory, and/or T cell persistence).
    Type: Grant
    Filed: January 29, 2024
    Date of Patent: May 6, 2025
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: Yangbing Zhao, Jiangtao Ren
  • Patent number: 12291699
    Abstract: The presently disclosed subject matter provides a biomimetic lung disease model, and methods of its production and use. In one exemplary embodiment, the biomimetic lung disease model can include a first and second microchannel with a membrane coated with airway epithelial cells disposed between the microchannels and at least one device coupled to the biomimetic model that delivers an agent to at least one microchannel. In certain embodiments, the agent is cigarette smoke.
    Type: Grant
    Filed: October 11, 2023
    Date of Patent: May 6, 2025
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: Dongeun Huh, Mark Mondrinos, Woo Yul Byun
  • Patent number: 12286401
    Abstract: Compounds and methods of treating HIV-1 in a human infected with HIV-1 or preventing HIV-1 infection in a human susceptible to infection with HIV-1 are provided. The compounds are of formula (I), (II), and (IA), wherein R1-R7, X, X?, Y, Y?, Z, and n are defined herein, and the methods comprises administering therapeutically effective amounts of these compounds to the human.
    Type: Grant
    Filed: July 31, 2019
    Date of Patent: April 29, 2025
    Assignees: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, VAL-CHUM, LIMITED PARTNERSHIP
    Inventors: Melissa Carey Davies, Amos B. Smith, III, Andres Finzi, Shilei Ding, Jean-Philippe Chapleau
  • Publication number: 20250127719
    Abstract: The present disclosure relates to ionizable lipidoid compounds comprising an anisamide moiety, and lipid nanoparticles (LNPs) comprising the same. In certain embodiments, the LNP selectively binds to at least one sigma receptor. In certain embodiments, the LNP specifically targets a cell of interest (e.g., a cell expressing a sigma receptor, fibroblast, cancer cell, stromal cell, and epithelial cell, inter alia). In another aspect, the present disclosure provides methods for in vivo delivery of therapeutic agents to treat, prevent, and/or ameliorate diseases and/or disorders, including but not limited to fibrosis and cancer.
    Type: Application
    Filed: December 6, 2022
    Publication date: April 24, 2025
    Applicant: The Trustees Of The University Of Pennsylvania
    Inventors: Michael J. Mitchell, Xuexiang Han
  • Publication number: 20250130224
    Abstract: Provided are systems and methods for tagging biomolecules of interest, methods of generating tagged biomolecules, and methods of use thereof. An adapter system comprises one or more epitope tags operably linked to an antibody binding domain (AbBD), which may be a photoreactive antibody binding domain (pAbBD). A pAbBD may be used to covalently photocrosslink epitope tags to immunoglobulins or immunoglobulin fragments, which may in turn be used to label biomolecules of interest. Such epitope-tagged immunoglobulins may be used in various biological research applications, including multiplexed staining assays and tandem affinity pulldown assays.
    Type: Application
    Filed: August 3, 2022
    Publication date: April 24, 2025
    Applicants: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, ALPHATHERA LLC
    Inventors: Andrew TSOURKAS, Yi Shu
  • Patent number: 12281167
    Abstract: The present invention relates to compositions and methods for treating diseases, disorders or conditions associated with the expression of the glycosyl-phosphatidylinositol (GPI)-linked GDNF family protein ?-receptor 4 (GFR?4).
    Type: Grant
    Filed: September 27, 2023
    Date of Patent: April 22, 2025
    Assignees: The Trustees of the University of Pennsylvania, University of Florida Research Foundation, Incorporated
    Inventors: Donald L. Siegel, Vijay Bhoj, Christoph Rader, Rebecca Goydel
  • Patent number: 12280108
    Abstract: The invention includes a vaccine comprising an antigen and IL-21. The invention also includes methods for increasing an immune response in a subject. The methods may comprise administering the vaccine to the subject in need thereof.
    Type: Grant
    Filed: April 15, 2021
    Date of Patent: April 22, 2025
    Assignees: The Trustees of the University of Pennsylvania, Inovio Pharmaceuticals, Inc.
    Inventors: David B. Weiner, Matthew P. Morrow
  • Patent number: 12282028
    Abstract: The present invention provides a mutant protein which has the same amino acid sequence of a wild type PF4 monomer except that (i) at least one amino acid of the wild type PF4 monomer has been deleted, (ii) at least one amino acid of the wild type PF4 monomer has been replaced by another amino acid, or (iii) a combination of such changes has been made. The present invention also provides methods of treating or reducing the likelihood of HIT, treating angiogenesis, treating abnormal cell growth, or affecting coagulation pathologies that lead to thrombus formation, by administering such mutant proteins to a patient.
    Type: Grant
    Filed: January 23, 2024
    Date of Patent: April 22, 2025
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: Mark I. Greene, Douglas B. Cines, Zheng Cai, Zhiqiang Zhu
  • Publication number: 20250116666
    Abstract: This present disclosure relates to the use of donor organ-derived microvesicles to monitor the status of a transplanted organ in a subject. Accordingly, this disclosure provides for methods and kits for isolating, purifying and/or identifying donor organ-derived microvesicles from a biological sample of a subject. In certain embodiments, a method for isolating, purifying and/or identifying donor organ-derived microvesicles includes obtaining a biological sample from the subject and isolating, purifying or identifying a donor organ-derived microvesicle from the biological sample by the detection of a protein specific for the donor.
    Type: Application
    Filed: December 18, 2024
    Publication date: April 10, 2025
    Applicant: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
    Inventor: Prashanth Vallabhajosyula
  • Patent number: 12270809
    Abstract: This invention relates to conjugate antibody, drug and nanoparticle compositions and methods of generating the same. This invention further relates to methods of using same for imaging, diagnosing or treating a disease.
    Type: Grant
    Filed: October 22, 2021
    Date of Patent: April 8, 2025
    Assignee: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
    Inventors: Andrew Tsourkas, James Z Hui
  • Patent number: 12268735
    Abstract: Nucleic acid molecules and compositions comprising one or more nucleic acid sequences that encode a consensus Marburgvirus filovirus glycoprotein immunogens. Immunomodulatory methods and methods of inducing an immune response against Marburgvirus are disclosed. Method of preventing infection by Marburgvirus and methods of treating individuals infected with Marburgvirus are disclosed. Consensus Marburgvirus filovirus glycoprotein immunogens are disclosed.
    Type: Grant
    Filed: March 7, 2023
    Date of Patent: April 8, 2025
    Assignees: The Wistar Institute of Anatomy and Biology, The Trustees of the University of Pennsylvania
    Inventors: David Weiner, Ami Patel, Sarah Elliott
  • Patent number: 12258379
    Abstract: The present invention includes compositions and methods comprising sortase immune receptors and sortase chimeric antigen receptors (CARs).
    Type: Grant
    Filed: October 12, 2019
    Date of Patent: March 25, 2025
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: Mauro Castellarin, June Carl
  • Publication number: 20250090018
    Abstract: A portable pupillometer for evaluating one or more pupils of a subject includes an optical assembly to stimulate the one or more pupils. The optical assembly has a light source to deliver a stimulus to the one or more pupils and a detector to capture images of the one or more pupils during delivery of the stimulus. A control device is coupled to the optical assembly, which has a controller to perform a plurality of operations in accordance with instructions stored in a digital memory. The plurality of operations includes: obtaining pupillary light reflex data comprising a plurality of Pupillary Light Reflex metrics during stimulation of the one or more pupils; analyzing the pupillary light reflex data based on one or more characteristics of the subject; determining a probability of a concussion injury suffered by the subject; and outputting the probability to a user of the pupillometer.
    Type: Application
    Filed: September 3, 2024
    Publication date: March 20, 2025
    Applicants: The Children's Hospital of Philadelphia, The Trustees of the University of Pennsylvania
    Inventors: Kristy B. Arbogast, Christina L. Master, Daniel Corwin, Matthew Grady, Catherine McDonald, Francesca Mandell, Ian Barnett
  • Patent number: 12252598
    Abstract: Systems and methods for achieving levitation via a photophoretic effect are provided. In certain embodiments, a structure of ultralight materials is provided, for example a BoPET film and carbon nanotubes and has a top and bottom side, made of two separate materials. When the bottom side is illuminated by light at certain intensity, it can result in an upward lift force being applied to the entire structure, causing the structure to levitate.
    Type: Grant
    Filed: May 12, 2022
    Date of Patent: March 18, 2025
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: Igor Bargatin, Zhipeng Lu, Mohsen Azadi
  • Patent number: 12251476
    Abstract: Embodiments of the present invention relate to mechanically-activated microcapsules (MAMCs) for controlled drug-delivery, wherein the MAMCs release one or more active ingredients in response to mechanical stimuli in a subject's body. The MAMCs provide a platform for stimulating biological regeneration, biological repair, modifying disease, and/or controlling disease in mechanically-loaded musculoskeletal tissues.
    Type: Grant
    Filed: August 3, 2022
    Date of Patent: March 18, 2025
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: Daeyeon Lee, Robert Leon Mauck, George R Dodge, Fuquan Tu, Bhavana Mohanraj
  • Patent number: 12245741
    Abstract: A method for generating and providing artificial intelligence assisted surgical guidance includes analyzing video images from surgical procedure and training a neural network to identify at least one of anatomical objects, surgical objects, and tissue manipulation in video images. The method includes receiving, by the neural network, a live feed of video images from the surgery. The method further includes classifying, by the neural network, at least one of anatomical objects, surgical objects, and tissue manipulation in the live feed of video images. The method further includes outputting, in real time, surgical guidance based on algorithms created using the classified at least on of anatomical objects, surgical objects, and tissue manipulations in the live feed of video images.
    Type: Grant
    Filed: July 25, 2019
    Date of Patent: March 11, 2025
    Assignee: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
    Inventors: Vivek Paresh Buch, Peter John Madsen, Jianbo Shi
  • Publication number: 20250073469
    Abstract: Methods and apparatus for improving cognitive function within a human. The invention utilizes a neurostimulation device, such as a signal generator, to affect tissue elements at a lateral temporal lobe of the human brain. The implanted device delivers treatment therapy to thereby improve cognitive function by the human. A sensor may be used to detect various characteristics of cognition. A microprocessor algorithm may then analyze the output from the sensor to regulate delivery of the stimulation therapy.
    Type: Application
    Filed: July 8, 2024
    Publication date: March 6, 2025
    Applicant: The Trustees of the University of Pennsylvania
    Inventors: Michael KAHANA, Daniel Sutton RIZZUTO
  • Patent number: 12240884
    Abstract: The invention provides methods of making immune effector cells (e.g., T cells, NK cells) that can be engineered to express a chimeric antigen receptor (CAR), compositions and reaction mixtures comprising the same, and methods of treatment using the same.
    Type: Grant
    Filed: September 18, 2020
    Date of Patent: March 4, 2025
    Assignees: Novartis AG, The Trustees of the University of Pennsylvania
    Inventors: Felipe Bedoya, Saba Ghassemi, Carl H. June, Omkar U. Kawalekar, Bruce L Levine, Jan J. Melenhorst, Michael C. Milone, Daniel J. Powell, Jr., Zoe Zheng
  • Patent number: 12240872
    Abstract: Nucleic acid molecules and compositions comprising one or more nucleic acid sequences that encode a consensus Ebolavirus glycoproteinimmunogens are disclosed. The coding sequences optionally include operable linked coding sequence that encode a signal peptide. Immunomodulatory methods and methods of inducing an immune response against Ebolavirus are disclosed. Method of preventing Ebolavirus and methods of treating individuals infected with Ebolavirus are disclosed. Consensus Ebolavirus proteins are disclosed.
    Type: Grant
    Filed: August 17, 2021
    Date of Patent: March 4, 2025
    Assignees: The Trustees of the University of Pennsylvania, The Wistar Institute of Anatomy and Biology, Inovio Pharmaceuticals, Inc.
    Inventors: David B. Weiner, Ami Patel, Jian Yan