Patents Assigned to The Trustees of the University of Pennsylvania
  • Publication number: 20200165301
    Abstract: De novo artificial protein based reporters that may be expressed in eukaryotic (e.g., mammalian) cells and methods of using the same are provided herein.
    Type: Application
    Filed: November 4, 2016
    Publication date: May 28, 2020
    Applicant: The Trustees of the University of Pennsylvania
    Inventors: Goutham KODALI, Molly Marie SHEEHAN, Joshua MANCINI, Bohdana Marie DISCHER, Michael MAGARACI, Nathan M. ENNIST, Brian CHOW, Peter Leslie DUTTON, Christopher MOSER
  • Patent number: 10655135
    Abstract: Disclosed herein are compositions and methods for treating Type II diabetes. The compositions comprise plant expressed Exendin 4. Particularly exemplified are plant derived compositions that include a CTB-EX4 conjugate that is bioencapsulated in chloroplasts.
    Type: Grant
    Filed: October 24, 2012
    Date of Patent: May 19, 2020
    Assignee: The Trustees of the University of Pennsylvania
    Inventor: Henry Daniell
  • Patent number: 10647960
    Abstract: The present invention includes methods for effecting phenotype conversion in a cell by transfecting the cell with phenotype-converting nucleic acid. Expression of the nucleic acids results in a phenotype conversion in the transfected cell. Preferably the phenotype-converting nucleic acid is a transcriptome, and more preferably an mRNA transcriptome.
    Type: Grant
    Filed: April 6, 2010
    Date of Patent: May 12, 2020
    Assignee: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
    Inventors: James Eberwine, Jai-Yoon Sul, Chia-Wen Wu, Fanyi Zeng, Junhyong Kim
  • Patent number: 10646590
    Abstract: The present invention includes methods for transferring a multigenic phenotype to a cell by transfecting, preferably by phototransfection, and locally transfecting a cell or a cellular process with a laser while the cell is bathed in a fluid medium comprising two or more nucleic acids, thereby introducing the nucleic acid into the interior of the cell. Expression of the nucleic acids results in a multigenic phenotype in the transfected cell.
    Type: Grant
    Filed: December 12, 2006
    Date of Patent: May 12, 2020
    Assignee: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
    Inventors: James Eberwine, Philip G. Haydon, Jai-Yoon Sul, Hajime Takano, Chia-Wen Kitty Wu, Fanyi Zeng
  • Patent number: 10646563
    Abstract: Compositions, recombinant vaccines and live attenuated pathogens comprising one or more isolated nucleic acid molecules that encode an immunogen in combination with an isolated nucleic acid molecule that encodes IL-28 or a functional fragment thereof are disclosed. Methods of inducing an immune response in an individual against an immunogen, using such compositions are disclosed.
    Type: Grant
    Filed: September 11, 2018
    Date of Patent: May 12, 2020
    Assignee: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
    Inventors: David B. Weiner, Matthew Morrow
  • Patent number: 10647998
    Abstract: Described herein are synonymously altered gene sequences which express protein in differing levels within secretory as compared to non-secretory target tissue. An expression cassette comprising an open reading frame (ORF) for a protein under the control of regulatory sequences which direct expression of the product in cell, which ORF has been modified to preferentially increase expression levels in a selected tissue, wherein the modified ORF is characterized by a triplet frequency of any one of Tables 3-12, 16 or 17.
    Type: Grant
    Filed: June 20, 2017
    Date of Patent: May 12, 2020
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: James M. Wilson, Anna Tretiakova
  • Patent number: 10647938
    Abstract: The presently disclosed technology relates to a nano-additives to improve the performance of lubricants, oils, and greases. More specifically, the presently disclosed technology relates to applying capped metal oxide nanoparticles, such as capped zirconia nanoparticles, in the lubricants to produce a tribofilms on the lubricating surfaces to provide wear protection to the said surfaces. Also, the interaction of the capped zirconia nanoparticles with other commonly used additives in lubricants may further optimize the performance of the resulting tribofilms.
    Type: Grant
    Filed: May 4, 2016
    Date of Patent: May 12, 2020
    Assignees: PIXELLIGENT TECHNOLOGIES, LLC, UCHICAGO ARGONNE, LLC, THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
    Inventors: Imene Lahouij, Robert Carpick, Andrew Jackson, Harman Khare, Nitya Gosvami, Nicholaos G. Demas, Robert A. Erck, Aaron C. Greco, George R. Fenske, Wei Xu, Gregory Cooper, Zhiyun Chen
  • Patent number: 10647758
    Abstract: A recombinant adeno-associated virus (AAV) having an AAV capsid and packaged therein a heterologous nucleic acid which expresses two functional antibody constructs in a cell is described. Also described are antibodies comprising a heavy chain and a light chain from a heterologous antibody. In one embodiment, the antibodies are co-expressed from a vector containing: a first expression cassette which encodes at least a first open reading frame (ORF) for a first immunoglobulin under the control of regulatory control sequences which direct expression thereof; and a second expression cassette which comprises a second ORF, a linker, and a third ORF under the control of regulatory control sequences which direct expression thereof, wherein the second and third ORF for a second and third immunoglobulin construct. The vector co-expressing these two antibody constructs is in one embodiment an AAV, in which the 5? and 3? ITRs flank the expression cassettes and regulatory sequences.
    Type: Grant
    Filed: July 2, 2019
    Date of Patent: May 12, 2020
    Assignee: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
    Inventors: James M. Wilson, Anna Tretiakova
  • Patent number: 10639458
    Abstract: The presently disclosed subject matter relates to methods and devices for decompressing the lymphatic system. In particular, the present disclosure provides devices for actively or passively decompressing the lymphatic system and methods of their use and deployment within a subject. In certain non-limiting embodiments, a device of the present disclosure can include a pump for actively transferring lymph fluid from the lymphatic fluid into the venous system.
    Type: Grant
    Filed: June 26, 2015
    Date of Patent: May 5, 2020
    Assignees: The Trustees of the University of Pennsylvania, The Children's Hospital of Philadelphia
    Inventors: Maxim Itkin, Yoav Dori
  • Patent number: 10638940
    Abstract: Electrocardiogram (ECG)-gated cardiac magnetic resonance imaging (MRI) alone may be unable to capture the hemodynamics associated with arrhythmic events. As a result, values such as ejection fraction are acquisition dependent. The desired RR-duration determines the arrhythmia rejection. By combining real-time volume measurements with ECG recordings, beat morphologies can be categorized and a more comprehensive evaluation of ventricular function during arrhythmia can be provided.
    Type: Grant
    Filed: February 4, 2016
    Date of Patent: May 5, 2020
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: Walter R. T. Witschey, Francisco Contijoch, Robert C. Gorman, Yuchi Han
  • Patent number: 10642616
    Abstract: Techniques are described for metadata processing that can be used to encode an arbitrary number of security policies for code running on a processor. Metadata may be added to every word in the system and a metadata processing unit may be used that works in parallel with data flow to enforce an arbitrary set of policies. In one aspect, the metadata may be characterized as unbounded and software programmable to be applicable to a wide range of metadata processing policies. Techniques and policies have a wide range of uses including, for example, safety, security, and synchronization. Additionally, described are aspects and techniques in connection with metadata processing in an embodiment based on the RISC-V architecture.
    Type: Grant
    Filed: June 16, 2017
    Date of Patent: May 5, 2020
    Assignees: The Charles Stark Draper Laboratory, Inc, The Trustees of the University of Pennsylvania Penn Center for Innovation
    Inventors: Andre' DeHon, Udit Dhawan
  • Patent number: 10640553
    Abstract: The present invention provides compositions and methods for regulating the specificity and activity of T cells. In one embodiment, the invention provides a type of chimeric antigen receptor (CAR) wherein the CAR is termed a “KIR-CAR” which is a CAR design comprising a component of a receptor naturally found on natural killer (NK) cells. In one embodiment, the NK receptor includes but is not limited to a naturally occurring activating and inhibitory receptor of NK cells known as a killer cell immunoglobulin-like receptor (KIR).
    Type: Grant
    Filed: July 24, 2017
    Date of Patent: May 5, 2020
    Assignees: Novartis AG, The Trustees of the University of Pennsylvania
    Inventors: Michael Milone, Enxiu Wang
  • Patent number: 10642360
    Abstract: Methods, systems, and computer readable media involving a content coupled physical activity surface are disclosed. One system includes a processor and a memory. The system is configured to receive information about a physical action performed by a user based on feedback from a physical activity surface including at least one sensor for detecting physical activity of the user, to determine, based on the feedback, configuration information, and metadata associated with a content coupled experience involving a physical action sequence, a second physical action to perform, information for prompting the user to perform the second physical action, and information for detecting the second physical action via the physical activity surface, and to provide, to the physical activity surface, the information for prompting the user to perform the second physical action and for detecting the second physical action via the physical activity surface.
    Type: Grant
    Filed: December 22, 2016
    Date of Patent: May 5, 2020
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: Rahul Mangharam, Orkan Telhan, Kuk Jin Jang, Matthew Edward O'Kelly
  • Patent number: 10640569
    Abstract: Provided are compositions and methods for treating diseases associated with expression of mesothelin. Also provided are a chimeric antigen receptor(CAR) specific to mesothelin, vectors encoding the same, and recombinant T cells comprising the mesothelin CAR. Further provided are methods of administering a genetically modified T cell expressing a CAR that comprises a mesothelin binding domain.
    Type: Grant
    Filed: December 19, 2014
    Date of Patent: May 5, 2020
    Assignees: Novartis AG, The Trustees of the University of Pennsylvania
    Inventors: Gregory Beatty, Boris Engels, Neeraja Idamakanti, Carl H. June, Andreas Loew, Huijuan Song, Qilong Wu
  • Patent number: 10632462
    Abstract: A microfluidic device includes an integrated circuit and a first substrate layer having a first surface and a second surface. The first surface of the first substrate layer is connected to the integrated circuit. The first substrate layer is in fluid communication with the integrated circuit. The microfluidic device also includes a second substrate layer having a surface area substantially larger than that of the first substrate layer. The second substrate layer includes a first and second surface. The first surface of the second substrate layer is connected to the second surface of the first substrate layer. The second substrate layer includes a first fluid inlet. The second substrate layer is in fluid communication with the integrated circuit through the first substrate layer.
    Type: Grant
    Filed: September 15, 2015
    Date of Patent: April 28, 2020
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: David Issadore, Melaku Muluneh Woldermariam
  • Patent number: 10632170
    Abstract: Methods for treating, preventing or delaying onset of tumor formation and other forms of cancer are disclosed. The methods involve administration of a complement inhibitor to inhibit C5a receptor signaling in the tumor microenvironment.
    Type: Grant
    Filed: February 19, 2009
    Date of Patent: April 28, 2020
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: John D. Lambris, Maciej M. Markiewski
  • Patent number: 10633623
    Abstract: The presently disclosed subject matter provides a microfluidic device that can simulate capillary blood flow on a fetal side of the device and pooled blood on a maternal side of the device (i.e., intervillous space). The microfluidic device can reconstitute the maternal-fetal interface, can expand the capabilities of cell culture models, and can provide an alternative to current maternal-fetal transfer models.
    Type: Grant
    Filed: March 23, 2016
    Date of Patent: April 28, 2020
    Assignee: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
    Inventors: Dongeun Huh, Cassidy Blundell
  • Patent number: 10632217
    Abstract: A device for rapidly sanitizing a surface is described. The device has an enclosure having an opening adapted to insert a surface, and an interior; a liquid nitric oxide solution applicator; and an absorbent material. The liquid nitric oxide solution applicator is in fluid communication with the interior of the enclosure and is adapted to apply liquid nitric oxide solution onto the surface when the surface is positioned within the enclosure. A method of rapidly sanitizing a surface is described. The devices and methods provided herein may be implemented to sanitize the surface of any body part or item that may be placed within the device. An infectious agent on the surface may be killed; i.e., the surface is disinfected. Non-limiting applications of the devices and methods include preventing nosocomial infections or food contamination, sanitizing household items, and implementing sanitizing procedures to comply with FDA Good Manufacturing Practices.
    Type: Grant
    Filed: December 29, 2017
    Date of Patent: April 28, 2020
    Assignee: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
    Inventor: Paul H. Axelsen
  • Patent number: 10624964
    Abstract: The presently disclosed subject matter relates to methods and compositions relating to immunostimulatory RNA motifs that act as adjuvants and/or immunostimulatory agents to enhance host immune responses.
    Type: Grant
    Filed: April 29, 2016
    Date of Patent: April 21, 2020
    Assignee: The Trustees of the University of Pennsylvania
    Inventor: Carolina B. Lopez
  • Patent number: 10626382
    Abstract: Non-viral delivery systems comprising engineered hOTC DNA and RNA sequences are provided which when delivered to a subject in need thereof are useful for treating hyperammonemia, ornithine transcarbamylase deficiency and symptoms associated therewith. Also provided are methods of using hOTC for treatment of liver fibrosis and/or cirrhosis in OTCD patients by administering hOTC.
    Type: Grant
    Filed: January 3, 2018
    Date of Patent: April 21, 2020
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: Lili Wang, James M. Wilson