Patents Assigned to The Trustees of the University of Pennsylvania
  • Patent number: 12258379
    Abstract: The present invention includes compositions and methods comprising sortase immune receptors and sortase chimeric antigen receptors (CARs).
    Type: Grant
    Filed: October 12, 2019
    Date of Patent: March 25, 2025
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: Mauro Castellarin, June Carl
  • Publication number: 20250090018
    Abstract: A portable pupillometer for evaluating one or more pupils of a subject includes an optical assembly to stimulate the one or more pupils. The optical assembly has a light source to deliver a stimulus to the one or more pupils and a detector to capture images of the one or more pupils during delivery of the stimulus. A control device is coupled to the optical assembly, which has a controller to perform a plurality of operations in accordance with instructions stored in a digital memory. The plurality of operations includes: obtaining pupillary light reflex data comprising a plurality of Pupillary Light Reflex metrics during stimulation of the one or more pupils; analyzing the pupillary light reflex data based on one or more characteristics of the subject; determining a probability of a concussion injury suffered by the subject; and outputting the probability to a user of the pupillometer.
    Type: Application
    Filed: September 3, 2024
    Publication date: March 20, 2025
    Applicants: The Children's Hospital of Philadelphia, The Trustees of the University of Pennsylvania
    Inventors: Kristy B. Arbogast, Christina L. Master, Daniel Corwin, Matthew Grady, Catherine McDonald, Francesca Mandell, Ian Barnett
  • Patent number: 12251476
    Abstract: Embodiments of the present invention relate to mechanically-activated microcapsules (MAMCs) for controlled drug-delivery, wherein the MAMCs release one or more active ingredients in response to mechanical stimuli in a subject's body. The MAMCs provide a platform for stimulating biological regeneration, biological repair, modifying disease, and/or controlling disease in mechanically-loaded musculoskeletal tissues.
    Type: Grant
    Filed: August 3, 2022
    Date of Patent: March 18, 2025
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: Daeyeon Lee, Robert Leon Mauck, George R Dodge, Fuquan Tu, Bhavana Mohanraj
  • Patent number: 12252598
    Abstract: Systems and methods for achieving levitation via a photophoretic effect are provided. In certain embodiments, a structure of ultralight materials is provided, for example a BoPET film and carbon nanotubes and has a top and bottom side, made of two separate materials. When the bottom side is illuminated by light at certain intensity, it can result in an upward lift force being applied to the entire structure, causing the structure to levitate.
    Type: Grant
    Filed: May 12, 2022
    Date of Patent: March 18, 2025
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: Igor Bargatin, Zhipeng Lu, Mohsen Azadi
  • Patent number: 12245741
    Abstract: A method for generating and providing artificial intelligence assisted surgical guidance includes analyzing video images from surgical procedure and training a neural network to identify at least one of anatomical objects, surgical objects, and tissue manipulation in video images. The method includes receiving, by the neural network, a live feed of video images from the surgery. The method further includes classifying, by the neural network, at least one of anatomical objects, surgical objects, and tissue manipulation in the live feed of video images. The method further includes outputting, in real time, surgical guidance based on algorithms created using the classified at least on of anatomical objects, surgical objects, and tissue manipulations in the live feed of video images.
    Type: Grant
    Filed: July 25, 2019
    Date of Patent: March 11, 2025
    Assignee: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
    Inventors: Vivek Paresh Buch, Peter John Madsen, Jianbo Shi
  • Publication number: 20250073469
    Abstract: Methods and apparatus for improving cognitive function within a human. The invention utilizes a neurostimulation device, such as a signal generator, to affect tissue elements at a lateral temporal lobe of the human brain. The implanted device delivers treatment therapy to thereby improve cognitive function by the human. A sensor may be used to detect various characteristics of cognition. A microprocessor algorithm may then analyze the output from the sensor to regulate delivery of the stimulation therapy.
    Type: Application
    Filed: July 8, 2024
    Publication date: March 6, 2025
    Applicant: The Trustees of the University of Pennsylvania
    Inventors: Michael KAHANA, Daniel Sutton RIZZUTO
  • Patent number: 12240884
    Abstract: The invention provides methods of making immune effector cells (e.g., T cells, NK cells) that can be engineered to express a chimeric antigen receptor (CAR), compositions and reaction mixtures comprising the same, and methods of treatment using the same.
    Type: Grant
    Filed: September 18, 2020
    Date of Patent: March 4, 2025
    Assignees: Novartis AG, The Trustees of the University of Pennsylvania
    Inventors: Felipe Bedoya, Saba Ghassemi, Carl H. June, Omkar U. Kawalekar, Bruce L Levine, Jan J. Melenhorst, Michael C. Milone, Daniel J. Powell, Jr., Zoe Zheng
  • Patent number: 12240872
    Abstract: Nucleic acid molecules and compositions comprising one or more nucleic acid sequences that encode a consensus Ebolavirus glycoproteinimmunogens are disclosed. The coding sequences optionally include operable linked coding sequence that encode a signal peptide. Immunomodulatory methods and methods of inducing an immune response against Ebolavirus are disclosed. Method of preventing Ebolavirus and methods of treating individuals infected with Ebolavirus are disclosed. Consensus Ebolavirus proteins are disclosed.
    Type: Grant
    Filed: August 17, 2021
    Date of Patent: March 4, 2025
    Assignees: The Trustees of the University of Pennsylvania, The Wistar Institute of Anatomy and Biology, Inovio Pharmaceuticals, Inc.
    Inventors: David B. Weiner, Ami Patel, Jian Yan
  • Publication number: 20250065123
    Abstract: The disclosed subject matter provides techniques for treating a subject. An example method includes placing a lead in a vertebral vein of the subject, placing at least one electrode within the vertebral vein adjacent to an autonomic nerve, and modulating a cardiovascular system of the subject by supplying a predetermined amount of an electrical stimulation energy to the autonomic nerve. In non-limiting embodiments, the lead can be placed in the vertebral vein via a subclavian vein, an axillary vein, or a combination thereof. In some embodiments, the at least one electrode can be coupled to the lead.
    Type: Application
    Filed: November 15, 2024
    Publication date: February 27, 2025
    Applicant: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
    Inventors: Timothy MARKMAN, Saman NAZARIAN
  • Patent number: 12234274
    Abstract: The present invention provides compositions and methods for treating cancer in a human. The invention includes relates to administering a genetically modified T cell expressing a CAR having an antigen binding domain, a transmembrane domain, a CD2 signaling domain, and a CD3 zeta signaling domain. The invention also includes incorporating CD2 into the CAR to alter the cytokine production of CAR-T cells in both negative and positive directions.
    Type: Grant
    Filed: August 5, 2021
    Date of Patent: February 25, 2025
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: Carl H. June, John Scholler, Avery D. Posey, Jr.
  • Publication number: 20250060368
    Abstract: Among the various aspects of the present disclosure is the provision of methods of detecting and treating immunotherapy-resistant B cell malignancies. Methods of detection include detecting a glycosylation state of CD19 or detecting expression or activity of SPPL3 in malignant B cells, comparing to a reference state or value, and determining that the B cell malignancy is resistant to immunotherapy if the glycosylation state of CD19 or expression or activity of SPPL3 is substantially increased or decreased relative to corresponding reference levels. Also provided are therapeutic agents capable of modulating CD19 glycosylation or SPPL3 expression or activity for treatment of B cell malignancies in combination with CD19-targeted immunotherapies.
    Type: Application
    Filed: February 7, 2023
    Publication date: February 20, 2025
    Applicants: Washington University, The Trustees of the University of Pennsylvania, University of Augsburg
    Inventors: Nathan Singh, Armin Ghobadi, Marco Ruella, Saar Gill, Regina Fluhrer
  • Publication number: 20250059567
    Abstract: Compositions and methods for effecting base editing to correct mutations in the phenylalanine hydroxylase gene, thereby curing phenylketonuria, are disclosed.
    Type: Application
    Filed: December 20, 2023
    Publication date: February 20, 2025
    Applicants: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, THE CHILDREN'S HOSPITAL OF PHILADELPHIA
    Inventors: Kiran Musunuru, Xiao Wang, Dominique Lynnette Brooks, Rebecca Ahrens-Nicklas
  • Patent number: 12227555
    Abstract: The present invention includes compositions and methods for a modified immune cell or precursor cell thereof comprising an inducible expression system. Also provided are gene edited modified immune cells suitable for T cell therapy. Methods of treatment using modified immune cells of the present invention are also provided.
    Type: Grant
    Filed: January 13, 2021
    Date of Patent: February 18, 2025
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: Yangbing Zhao, Xiaojun Liu, Wei Pan
  • Patent number: 12229226
    Abstract: A system and method for generating a decision tree having a plurality of nodes, arranged hierarchically as parent nodes and child nodes, comprising: generating a node including: receiving i) training data including data instances, each data instance having a plurality of attributes and a corresponding label, ii) instance weightings, iii) a valid domain for each attribute generated, and iv) an accumulated weighted sum of predictions for a branch of the decision tree; and associating one of a plurality of binary prediction of an attribute with each node including selecting the one of the plurality of binary predictions having a least amount of error; in accordance with a determination that the node includes child nodes, repeat the generating the node step for the child nodes; and in accordance with a determination that the node is a terminal node, associating the terminal node with an outcome classifier; and displaying the decision tree including the plurality of nodes arranged hierarchically.
    Type: Grant
    Filed: June 30, 2017
    Date of Patent: February 18, 2025
    Assignee: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
    Inventors: Gilmer Valdes, Timothy D. Solberg, Charles B. Simone, II, Lyle H. Ungar, Eric Eaton, Jose Marcio Luna
  • Patent number: 12227588
    Abstract: The present invention includes compositions and methods for treating T cell lymphomas and leukemias. In certain aspects, the compositions and methods include CAR T cells targeting CD2, CD5, or CD7 and modified cells wherein CD2, CD5, or CD7 has been knocked-out.
    Type: Grant
    Filed: March 28, 2024
    Date of Patent: February 18, 2025
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: Marco Ruella, Saar Gill, Carl H. June, Avery D. Posey, Daniel J. Powell
  • Patent number: 12226471
    Abstract: The present invention relates to compositions and methods for inducing an adaptive immune response against Hepatitis C virus (HCV) in a subject. In some embodiments, the present invention provides a composition comprising a nucleoside-modified nucleic acid molecule encoding a HCV antigen, adjuvant, or a combination thereof. For example, in some embodiments, the composition comprises a vaccine comprising a nucleoside-modified nucleic acid molecule encoding a HCV antigen, adjuvant, or a combination thereof.
    Type: Grant
    Filed: May 1, 2023
    Date of Patent: February 18, 2025
    Assignees: The Trustees of the University of Pennsylvania, The Johns Hopkins University, Vanderbilt University
    Inventors: Drew Weissman, George M. Shaw, Justin R. Bailey, Stuart C. Ray, James Crowe, Jr., Andrew Flyak
  • Publication number: 20250049949
    Abstract: Provided herein is a recombinant AAV (rAAV) comprising an AAV capsid and a vector genome packaged therein, wherein the vector genome comprises an AAV 5? inverted terminal repeat (ITR), an expression cassette comprising an open reading frame (ORF) for a mature human Lamin A (hLaminA) under control of a regulatory sequence which direct expression of mature hLaminA in a target cell, and an AAV 3? ITR. Also provided is a pharmaceutical composition comprising a rAAV as described herein in a formulation buffer, and a method of treatment of idiopathic dilated cardiomyopathy (DCM) or a disease associated with a mutation in a Lamin A (LMNA) gene.
    Type: Application
    Filed: December 24, 2022
    Publication date: February 13, 2025
    Applicant: The Trustees of the University of Pennsylvania
    Inventor: Christian Hinderer
  • Publication number: 20250051296
    Abstract: Formulations and methods for reducing blood glucose and/or increasing insulin signaling in a subject have been developed. The formulations include SBI-477 and compounds based on SBI-477 i.e., SBI-477 analogs (collectively, SBI-477 compounds) and/or Mondo family inhibitors, in an effective amount to inhibit intracellular lipid accumulation and/or increase cellular glucose uptake when compared to levels in a control subject not administered the composition. Also disclosed are methods of reducing intracellular lipid accumulation and/or increase glucose uptake in a subject in need thereof. The method includes administering to the subject an effective amount of SBI-477 compounds and/or Mondo family inhibitor to reducing intracellular lipid accumulation and/or increase glucose uptake in the subject.
    Type: Application
    Filed: August 9, 2024
    Publication date: February 13, 2025
    Applicant: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
    Inventors: Daniel Kelly, Richard Vega, Hampton Sessions, Teresa Leone, Byungyong Ahn, Satyamaheshwar Peddibhotla
  • Patent number: 12223655
    Abstract: A computerized method of providing automatic anatomy recognition (AAR) includes gathering image data from patient image sets, formulating precise definitions of each body region and organ and delineating them following the definitions, building hierarchical fuzzy anatomy models of organs for each body region, recognizing and locating organs in given images by employing the hierarchical models, and delineating the organs following the hierarchy. The method may be applied, for example, to body regions including the thorax, abdomen and neck regions to identify organs.
    Type: Grant
    Filed: January 6, 2022
    Date of Patent: February 11, 2025
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: Jayaram K. Udupa, Dewey Odhner, Drew A. Torigian, Yubing Tong
  • Patent number: 12221615
    Abstract: Compositions and methods for treating type II diabetes in a subject. A viral vector is provided which includes a nucleic acid molecule comprising a sequence encoding a propeptide and the active portion of GLP-1, wherein, when expressed, the N-terminal amino acid of GLP-1 immediately follows the C-terminal amino acid of the propeptide. In desired embodiments, the subject is a cat or dog.
    Type: Grant
    Filed: August 5, 2016
    Date of Patent: February 11, 2025
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: Christian Hinderer, James M. Wilson, Matthew Wilson