Patents Assigned to The Trustees of the University of Pennsylvania
  • Publication number: 20180297000
    Abstract: In one aspects of the invention, a microcapsule includes a film encapsulating a material. The film is formed by complexation of at least two mutually attractive components initially present in an aqueous dispersion comprising a continuous phase and a dispersed phase. The at least one first component is initially present in the continuous phase and the at least one second component is initially present in the dispersed phase. According to another aspect of the invention, provided is a process for forming microcapsules including the step of injecting a dispersed phase having at least a first component into a continuous phase having at least a second component, where the first component and the second component are mutually attractive, such that a film is formed by complexation of the first charged component and the second charged component.
    Type: Application
    Filed: April 13, 2018
    Publication date: October 18, 2018
    Applicant: The Trustees of the University of Pennsylvania
    Inventors: Daeyeon Lee, Kathleen J. Stebe, Sarah D. Hann
  • Publication number: 20180297039
    Abstract: A magnetic separation filter has an unsupported magnetically soft material layer having a plurality of pores, and, optionally, a passivation layer disposed on the magnetically soft material layer. The magnetic separation filter may be part of a microfluidic device having a lateral flow channel and a vertical flow magnetic separation filter. The magnetic separation device may be used to separate magnetically tagged particles, such as cells.
    Type: Application
    Filed: October 4, 2016
    Publication date: October 18, 2018
    Applicant: The Trustees of the University of Pennsylvania
    Inventors: David Issadore, Venkata Yelleswarapu, Jina Ko
  • Patent number: 10096733
    Abstract: Methods of preparing a dispersion of colloidal nanocrystals (NCs) for use as NC thin films are disclosed. A dispersion of NCs capped with ligands may be mixed with a solution containing chalcogenocyanate (xCN)-based ligands. The mixture may be separated into a supernatant and a flocculate. The flocculate may be dispersed with a solvent to form a subsequent dispersion of NCs capped with xCN-based ligands.
    Type: Grant
    Filed: May 10, 2016
    Date of Patent: October 9, 2018
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: Cherie R. Kagan, Aaron T. Fafarman, Ji-Hyuk Choi, Weon-Kyu Koh, David K. Kim, Soong Ju Oh, Yuming Lai, Sung-Hoon Hong, Sangameshwar Rao Saudari, Christopher B. Murray
  • Patent number: 10096729
    Abstract: The present invention provides materials with high bulk photovoltaic effect response. The present invention also provides for products comprising the high bulk photovoltaic effect materials of the present invention.
    Type: Grant
    Filed: January 23, 2015
    Date of Patent: October 9, 2018
    Assignee: The Trustees of The University of Pennsylvania
    Inventors: Andrew M. Rappe, Steve M. Young, Fan Zheng
  • Patent number: 10092324
    Abstract: Disclosed are systems, methods, and devices for percutaneous retrieval of objects, such as endovascular devices, from an internal body space. The present inventions have vascular, non-vascular (gastrointestinal), and surgical (laproscopic) applications. The inventions include a retrieval end having one or more compressed states and an expanded state, the retrieval end adopting the expanded state when the retrieval end is deployed into a subject's internal body space, the retrieval end having a mouth through which an object can be passed into an interior space within the retrieval end when the retrieval end is in the expanded state, the mouth being adjustable between an opened state and a closed state; wherein when at least a portion of the retrieval end of the inner sheath is transitioned to a compressed state following capture of the object, the retrieval end exerts an inward force that at least partially collapses or compresses the object.
    Type: Grant
    Filed: September 2, 2016
    Date of Patent: October 9, 2018
    Assignees: The Trustees of the University of Pennsylvania, The Children's Hospital of Philadelphia
    Inventors: Matthew J. Gillespie, Joseph H. Gorman, III, Robert C. Gorman, Mark Piper
  • Patent number: 10092243
    Abstract: A personal electronic device (PED)-endoscope image and diagnosis capture system is provided. The system includes a PED adapter having a magnification lens connection side and a PED connection side. A magnification lens is connectable with the lens connection side of the PED adapter. An eyepiece lens coupler is also provided and connects the magnification lens to the endoscope eyepiece. A PED is connected to the PED adapter and includes a processor, a memory and an image capture system with a PED lens. The PED adapter aligns the magnification lens with the PED lens. The processor is configured to activate the image capture system using a remote or voice-activated trigger signal and store captured images in the PED memory. Patient data and examination data can be associated with the images, and the images and data can be transferred from the PED to an electronic medical records system.
    Type: Grant
    Filed: October 23, 2013
    Date of Patent: October 9, 2018
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: Natasha Mirza, Jason Brant
  • Patent number: 10093746
    Abstract: The present invention relates to compositions and methods of isolated polynucleotides that encode or polypeptides comprising glypican-3 (GPC3). The invention also includes a chimeric antigen receptor (CAR) wherein the CAR is able to target GPC3. The invention further includes methods of treating a subject or diagnosing and treating diseases, disorders or conditions associated with dysregulated glypican-3.
    Type: Grant
    Filed: September 3, 2015
    Date of Patent: October 9, 2018
    Assignees: The Trustees of the University of Pennsylvania, The United States of America as represented by the Department of Veterans Affairs
    Inventor: David Kaplan
  • Patent number: 10096734
    Abstract: Methods of forming colloidal nanocrystal (NC)-based thin film devicesare disclosed. The methods include the steps of depositing a dispersion of NCs on a substrate to form a NC thin-film, wherein at least a portion of the NCs is capped with chalcogenocyanate (xCN)-based ligands; and doping the NC thin-film with a metal.
    Type: Grant
    Filed: May 10, 2016
    Date of Patent: October 9, 2018
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: Cherie R. Kagan, Aaron T. Fafarman, Ji-Hyuk Choi, Weon-Kyu Koh, David K. Kim, Soong Ju Oh, Yuming Lai, Sung-Hoon Hong, Sangameshwar Rao Saudari, Christopher B. Murray
  • Patent number: 10093917
    Abstract: The present invention includes compositions, methods and kits for the real-time detection of transcription and translation in live cells, tissues and organisms. The present invention further provides method for the rapid sequencing of nucleic acids without using conventional sequencing techniques or reactions.
    Type: Grant
    Filed: December 31, 2015
    Date of Patent: October 9, 2018
    Assignee: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
    Inventors: James Eberwine, Ulo Langel, Emelia Eiriksdottir, Tiina Peritz [nee Pajunen], Jai-Yoon Sul, Philip G. Haydon, Junhyong Kim
  • Publication number: 20180280462
    Abstract: The invention provides compositions and methods for treating neurological disorders and viral infection using whole-grain flaxseed, flaxseed lignans such as Secoisolariciresinol diglucoside (SDG), human lignans metabolized from flaxseed such as Enterodiol (ED) or Enterolactone (EL), and synthetic flaxseed lignan analogs.
    Type: Application
    Filed: June 1, 2018
    Publication date: October 4, 2018
    Applicant: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
    Inventors: Melpo CHRISTOFIDOU-SOLOMIDOU, Kelly JORDAN-SCIUTTO
  • Publication number: 20180281028
    Abstract: An ultrasonication apparatus is provided for improving catheter function. The ultrasonication apparatus includes a transducer configured to produce ultrasonic waves for ultrasonication and a chamber for containing a fluid having a passage for receiving a catheter. The chamber is adapted to receive the ultrasonic waves from the transducer.
    Type: Application
    Filed: October 18, 2016
    Publication date: October 4, 2018
    Applicant: The Trustees of the University of Pennsylvania
    Inventors: Jayesh P. Thawani, Jared M. Pisapia, Hongjie Zhu, M. Sean Grady, Andrew Tsourkas
  • Publication number: 20180280475
    Abstract: The present invention provides methods for treating hair loss, treating, inhibiting, or suppressing a degenerative skin disorder, treating androgenetic alopecia (AGA), generating new hair follicles (HF), and increasing the size of existing HF. The methods comprise epidermal disruption or administration of wnt, and administration of a fibroblast growth factor-9 polypeptide or another compound that upregulates sonic hedgehog gene signaling.
    Type: Application
    Filed: June 8, 2018
    Publication date: October 4, 2018
    Applicant: The Trustees of the University of Pennsylvania
    Inventors: George Cotsarelis, Oh Sang Kwon
  • Publication number: 20180271835
    Abstract: Provided are compositions for inhibiting a biological activity of an aldo-keto reductase family 1, member C3 (AKR1C3) polypeptide. In some embodiments, the compositions are indomethacin derivatives that are AKR1C3-specific inhibitors. Also provided are methods for producing disclosed indomethacin derivatives that substantially lack cyclooxygenase inhibitory activity but that have AKR1C3 inhibitory activity, methods for inhibiting AKR1C3 polypeptide biological activities, and methods for treating prostate tumors in subjects.
    Type: Application
    Filed: February 19, 2018
    Publication date: September 27, 2018
    Applicants: Vanderbilt University, The Trustees of the University of Pennsylvania
    Inventors: Lawrence J. Marnett, Andy J. Liedtke, Trevor M. Penning, Adegoke O. Adeniji, Michael C. Byrns
  • Patent number: 10081810
    Abstract: The present invention provides a c-Rel-specific siRNA and its use for preventing and treating autoimmune psoriasis. In particular, the c-Rel-specific siRNAs have sequences as shown in SEQ ID Nos. 1-2 or SEQ ID Nos. 3-4. In the present invention, small interfering RNA (siRel) specific to c-Rel are employed to inhibit c-Rel biosynthesis, and prevent and treat autoimmune psoriasis by inhibiting inflammatory factors relating to IL-23/IL-17A inflammatory axis.
    Type: Grant
    Filed: August 18, 2017
    Date of Patent: September 25, 2018
    Assignees: SHENZHEN INSTITUTES OF ADVANCED TECHNOLOGY, THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
    Inventors: Qingguo Ruan, Youhai H. Chen, Tingting Fan, Yifan Ma, Lintao Cai, Shaowen Wang, Xiaochun Wan
  • Patent number: 10080771
    Abstract: Compositions and methods for generating human epithelial stem cells from induced pluripotent stem cells are disclosed. Also disclosed are methods of using cells so generated in hair transplant procedures.
    Type: Grant
    Filed: January 28, 2016
    Date of Patent: September 25, 2018
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: Xiaowei Xu, Ruifeng Yang
  • Publication number: 20180265565
    Abstract: The present invention relates to compositions and methods for treating of a HIV infected mammal using a CD4 membrane-bound chimeric receptor or a HIV specific scFvs CARs. One aspect includes a modified T cell and pharmaceutical compositions comprising the modified cells for adoptive cell therapy and treating a disease or condition associated with HIV infection.
    Type: Application
    Filed: September 22, 2016
    Publication date: September 20, 2018
    Applicant: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
    Inventors: James L. Riley, Rachel Leibman, Aimee S. Payne, Christoph T. Ellebrecht, Michael C. Milone
  • Patent number: 10076565
    Abstract: An aspect of the present invention is directed towards DNA plasmid vaccines capable of generating in a mammal an immune response against a plurality of influenza virus subtypes, comprising a DNA plasmid and a pharmaceutically acceptable excipient. The DNA plasmid is capable of expressing a consensus influenza antigen in a cell of the mammal in a quantity effective to elicit an immune response in the mammal, wherein the consensus influenza antigen comprises consensus hemagglutinin (HA), neuraminidase (NA), matrix protein, nucleoprotein, M2 ectodomain-nucleo-protein (M2e-NP), or a combination thereof. Preferably the consensus influenza antigen comprises HA, NA, M2e-NP, or a combination thereof. The DNA plasmid comprises a promoter operably linked to a coding sequence that encodes the consensus influenza antigen. Additionally, an aspect of the present invention includes methods of eliciting an immune response against a plurality of influenza virus subtypes in a mammal using the DNA plasmid vaccines provided.
    Type: Grant
    Filed: January 26, 2017
    Date of Patent: September 18, 2018
    Assignee: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
    Inventors: Ruxandra Draghia-Akli, David B. Weiner, Jian Yan, Dominick Laddy
  • Patent number: 10078763
    Abstract: A system and method for metadata processing that can be used to encode an arbitrary number of security policies for code running on a stored-program processor. This disclosure adds metadata to every word in the system and adds a metadata processing unit that works in parallel with data flow to enforce an arbitrary set of policies, such that metadata is unbounded and software programmable to be applicable to a wide range of metadata processing policies. This instant disclosure is applicable to a wide range of uses including safety, security, and synchronization.
    Type: Grant
    Filed: November 19, 2015
    Date of Patent: September 18, 2018
    Assignees: BAE Systems Information and Electronic Systems Integration Incc, The Trustees of the University of Pennsylvania
    Inventors: Silviu Chiricescu, Andre DeHon, Udit Dhawan
  • Publication number: 20180258149
    Abstract: The invention provides compositions and methods improved CAR T cell therapies. Specifically, the invention provides cells with reduced Tet, e.g., Tet2 function or expression, and methods of use therefore. The invention further provides Tet2 inhibitors and methods of use therefore in connection with CAR T cells.
    Type: Application
    Filed: September 16, 2016
    Publication date: September 13, 2018
    Applicants: Novartis AG, The Trustees of the University of Pennsylvania
    Inventors: Gregory Motz, Frederic Dixon Bushman, Joseph A. Fraietta, Carl H. June, Jan J. Melenhorst, Christopher Loren Nobles, Regina M. Young
  • Patent number: 10071953
    Abstract: The invention includes compositions comprising selective AKR1C3 inhibitors. The invention also includes compositions comprising bifunctional AKR1C3 inhibitors and selective androgen receptor modulators. The invention further includes methods of treatment using the compositions of the invention.
    Type: Grant
    Filed: January 12, 2016
    Date of Patent: September 11, 2018
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: Trevor M. Penning, Adegoke O. Adeniji, Michael C. Byrns, Jeffrey Winkler, Barry Twenter