Patents Assigned to The Trustees of the University of Pennsylvania
  • Patent number: 10207919
    Abstract: The present disclosure relates to a hybrid nanoparticle comprising a metallic core and at least one lipophilic dendron attached to the surface of the metallic core, and methods of producing such hybrid nanoparticles. The present disclosure also relates to films containing the hybrid nanoparticles described herein.
    Type: Grant
    Filed: June 10, 2016
    Date of Patent: February 19, 2019
    Assignees: Rhodia Operations, Centre National De La Recherche Scientifique, The Trustees of the University of Pennsylvania
    Inventors: Bertrand Donnio, Davit Jishkariani, Benjamin Diroll, Lawrence Alan Hough, Christopher Murray, Matteo Cargnello, Ludivine Malassis
  • Publication number: 20190050005
    Abstract: A method of controlling a motor may include receiving command data indicating only a desired torque and/or force for the motor and including no torque and/or force or current feedback data from the motor. Based on the command data and at least one motor characteristic and no separate torque and/or force or current feedback data, a voltage signal corresponding to a desired motor current to produce the desired torque and/or force may be generated. A control signal configured to provide the motor with the desired motor current may be generated using only the voltage signal as an input. The motor may be controlled by inputting the control signal to the motor, and the inputting may cause the motor to output substantially the desired torque and/or force.
    Type: Application
    Filed: February 2, 2017
    Publication date: February 14, 2019
    Applicant: The Trustees of the University of Pennsylvania
    Inventors: Gavin KENNEALLY, Avik DE
  • Patent number: 10203335
    Abstract: Provided are methods for labeling transfer RNA comprising replacing the uracil component of a dihydrouridine of said transfer RNA with a fluorophore. The disclosed methods may comprise fluorescent labeling of natural tRNAs (i.e., tRNAs that have been synthesized in a cell, for example, in a bacterium, a yeast cell, or a vertebrate cell) at dihydrouridine (D) positions, or fluorescent labeling of synthetic tRNAs. In another aspect, the present invention provides methods for assessing protein synthesis in a translation system comprise providing a tRNA having a fluorophore substitution for the uracil component of a dihydrouridine in a D loop of the tRNA; introducing the labeled tRNA into the translation system; irradiating the translation system with electromagnetic radiation, thereby generating a fluorescence signal from the fluorophore; detecting the fluorescence signal; and, correlating the fluorescence signal to one or more characteristics of the protein synthesis in the translation system.
    Type: Grant
    Filed: February 9, 2017
    Date of Patent: February 12, 2019
    Assignees: The Trustees of the University of Pennsylvania, Anima Cell Metrology
    Inventors: Barry S. Cooperman, Zeev Smilansky, Yale E. Goldman, Dongli Pan
  • Patent number: 10201598
    Abstract: Compositions comprising a nucleic acid molecule that encodes TB esat-6 proteins are disclosed. Methods of inducing an immune response against TB an individual are disclosed. Method of treating an individual who has been diagnosed with TB are disclosed. Method of preventing TB infection in an individual are disclosed.
    Type: Grant
    Filed: September 26, 2017
    Date of Patent: February 12, 2019
    Assignee: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
    Inventors: David B. Weiner, Daniel Villarreal
  • Publication number: 20190038652
    Abstract: The invention provides compositions and methods for treating asthma in a subject in need thereof comprising administering chemically synthesized secoisolaricirecinol diglucoside (SDG), and in particular, a racemic mixture of the SDG (LGM2605), stereoisomers thereof, metabolites thereof, and analogs thereof. Also provided are methods for treating or preventing ozone-induced damage in a subject in need thereof.
    Type: Application
    Filed: October 5, 2018
    Publication date: February 7, 2019
    Applicant: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
    Inventor: Melpo CHRISTOFIDOU-SOLOMIDOU
  • Publication number: 20190038232
    Abstract: A personal electronic device (PED)—endoscope image and diagnosis capture system is provided. The system includes a PED adapter having a magnification lens connection side and a PED connection side. A magnification lens is connectable with the lens connection side of the PED adapter. An eyepiece lens coupler is also provided and connects the magnification lens to the endoscope eyepiece. A PED is connected to the PED adapter and includes a processor, a memory and an image capture system with a PED lens. The PED adapter aligns the magnification lens with the PED lens. The processor is configured to activate the image capture system using a remote or voice-activated trigger signal and store captured images in the PED memory. Patient data and examination data can be associated with the images, and the images and data can be transferred from the PED to an electronic medical records system.
    Type: Application
    Filed: October 8, 2018
    Publication date: February 7, 2019
    Applicant: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
    Inventors: Natasha Mirza, Jason Brant
  • Patent number: 10195268
    Abstract: Provided herein are nucleic acid sequences that encode novel consensus amino acid sequences of HBV core protein, as well as genetic constructs/vectors and vaccines that express said protein sequences. Also provided herein are methods for generating an immune response against HBV using the nucleic acid sequences that are provided.
    Type: Grant
    Filed: July 19, 2016
    Date of Patent: February 5, 2019
    Assignee: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
    Inventors: David Weiner, Jian Yan, Nyamekye Obeng-Adjei
  • Publication number: 20190030145
    Abstract: The present invention provides methods of treating, protecting against, and inducing an immune response against a human papillomavirus-associated oropharyngeal tumor or cancer, comprising the step of administering to a subject a recombinant Listeria strain expressing a human papillomavirus antigen.
    Type: Application
    Filed: July 2, 2018
    Publication date: January 31, 2019
    Applicant: The Trustees of the University of Pennsylvania
    Inventor: Yvonne Paterson
  • Publication number: 20190029788
    Abstract: Techniques for mesh augmentation and prevention of incisional hernia, including systems and methods for affixing mesh to a fascial incision. A mesh strip can be integrated with one or more uni-directional fasteners. Each fastener can include an anchoring mechanism adapted for affixation to anterior abdominal wall fascia and a mating interface. An applicator can include tension arms adapted to interface with the mating interfaces of the fasteners to maintain a vertical tension of the mesh strip and a handle coupled with the tension arms adapted to spread the tension arms and thereby control a horizontal tension of the mesh strip. The mesh strip can be configured to be aligned over a fascial incision using the applicator and affixed under tension to anterior abdominal wall fascia by tissue penetration of the anchoring mechanisms of the one or more fasteners.
    Type: Application
    Filed: October 4, 2018
    Publication date: January 31, 2019
    Applicant: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
    Inventor: John Patrick Fischer
  • Patent number: 10189884
    Abstract: The invention includes a thioamide-modified peptide, wherein the thioamide modification increases the in vivo half-life of the peptide. The invention further includes methods of treating or preventing a disease or disorder in a subject in need thereof, the method comprising administering to the subject a thioamide-modified peptide of the invention.
    Type: Grant
    Filed: April 28, 2015
    Date of Patent: January 29, 2019
    Assignees: The Trustees of the University of Pennsylvania, President and Fellows of Harvard College
    Inventors: E. James Petersson, Alan Saghatelian
  • Patent number: 10189885
    Abstract: The present invention provides recombinant proteins or peptides comprising a mutated listeriolysin O (LLO) protein or fragment thereof, comprising a substitution or internal deletion of the cholesterol-binding domain or a portion thereof, fusion proteins or peptides comprising same, nucleotide molecules encoding same, and vaccine vectors comprising or encoding same. The present invention also provides methods of utilizing recombinant proteins, peptides, nucleotide molecules, and vaccine vectors of the present invention to induce an immune response to a peptide of interest.
    Type: Grant
    Filed: July 1, 2015
    Date of Patent: January 29, 2019
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: Yvonne Paterson, Paulo Maciag
  • Patent number: 10188702
    Abstract: This invention relates to methods of treating and ameliorating congenital and neonatal hyperinsulinism and post-prandial hypoglycemia, comprising the step of administering an antagonist of the Glucagon-Like Peptide-1 (GLP-1) receptor, e.g. a GLP-1 fragment or analog thereof.
    Type: Grant
    Filed: March 8, 2017
    Date of Patent: January 29, 2019
    Assignees: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, CHILDREN'S HOSPITAL OF PHILADELPHIA
    Inventors: Doris Stoffers, Diva D. De Leon, Charles Stanley
  • Patent number: 10183404
    Abstract: Linear motion devices that may include a band configured to be helically interlinked into a tube, where the band includes a plurality of protrusions and a plurality of recesses that engage the plurality of protrusions to link the band with itself. The linear motion devices also include a sliding guide configured to link and unlink the band, where the sliding guide includes an outer layer, an inner layer, and a ramp between the outer and inner layers having a helical incline to support a bottom portion of the band. The linear motion devices include a driving mechanism that is in contact with the band, the driving mechanism configured to move the band through the sliding guide up the helical incline to link the band, thereby extending the tube, and to move the band through the sliding guide down the helical incline to unlink the band, thereby retracting the tube.
    Type: Grant
    Filed: January 23, 2015
    Date of Patent: January 22, 2019
    Assignee: The Trustees of the University of Pennsylvania
    Inventor: Mark Yim
  • Publication number: 20190017084
    Abstract: Disclosed herein are methods for multiple stage isothermal amplification of nucleic acid comprising a first substantially isothermal amplification reaction on the nucleic acid to generate a first amplification product and at least one substantially isothermal amplification reaction on the first amplification product to generate at least one second amplification product in an amount sufficient for recovery, testing, or characterization.
    Type: Application
    Filed: January 13, 2017
    Publication date: January 17, 2019
    Applicant: The Trustees Of The University Of Pennsylvania
    Inventors: Haim H. BAU, Michael G. MAUK, Jinzhao SONG, Changchun LIU
  • Publication number: 20190016758
    Abstract: Compounds comprising peptides and peptidomimetics capable of binding C3 protein and inhibiting complement activation are disclosed. These compounds display greatly improved complement activation-inhibitory activity as compared with currently available compounds. Methods of making and using the compounds are also disclosed.
    Type: Application
    Filed: January 25, 2018
    Publication date: January 17, 2019
    Applicant: The Trustees of the University of Pennsylvania
    Inventors: John D. Lambris, Madan Katragadda
  • Publication number: 20190010394
    Abstract: Monodisperse particles having: a single pure crystalline phase of a rare earth-containing lattice, a uniform three-dimensional size, and a uniform polyhedral morphology are disclosed. Due to their uniform size and shape, the monodisperse particles self assemble into superlattices. The particles may be luminescent particles such as down-converting phosphor particles and up-converting phosphors. The monodisperse particles of the invention have a rare earth-containing lattice which in one embodiment may be an yttrium-containing lattice or in another may be a lanthanide-containing lattice. The monodisperse particles may have different optical properties based on their composition, their size, and/or their morphology (or shape).
    Type: Application
    Filed: August 30, 2018
    Publication date: January 10, 2019
    Applicants: INTELLIGENT MATERIAL SOLUTIONS, INC., THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
    Inventors: Joshua E. COLLINS, Howard Y. BELL, Xingchen YE, Christopher Bruce MURRAY
  • Patent number: 10174083
    Abstract: The invention relates to aza-amino acid backbone-modified biomimetic collagens and general methods for designing and making biomimetic materials and molecular mimics.
    Type: Grant
    Filed: April 28, 2017
    Date of Patent: January 8, 2019
    Assignee: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
    Inventors: David M. Chenoweth, Yitao Zhang
  • Patent number: 10174095
    Abstract: The invention provides compositions and methods for treating diseases associated with expression of BCMA. The invention also relates to chimeric antigen receptor (CAR) specific to BCMA vectors encoding the same, and recombinant T cells comprising the BCMA CAR. The invention also includes methods of administering a genetically modified T cell expressing a CAR that comprises a BCMA binding domain.
    Type: Grant
    Filed: July 21, 2015
    Date of Patent: January 8, 2019
    Assignees: Novartis AG, The Trustees of the University of Pennsylvania
    Inventors: Jennifer Brogdon, Eugene Choi, Hilmar Erhard Ebersbach, David Glass, Heather Huet, Carl H. June, Joan Mannick, Michael C. Milone, Leon Murphy, Gabriela Plesa, Celeste Richardson, Marco Ruella, Reshma Singh, Yongqiang Wang, Qilong Wu
  • Patent number: 10174079
    Abstract: Compounds comprising peptides capable of binding C3 protein and inhibiting complement activation are disclosed. The compounds comprise compstatin analogs in which the N-terminus contains an added or substituted component that improves (1) the peptide's binding affinity to C3 or its fragments, (2) the peptide's solubility in aqueous liquids, (3) the peptide's plasma stability, (4) the peptide's in vivo retention and/or (5) the peptide's bioavailability, as compared with an unmodified compstatin peptide under equivalent conditions. Pharmaceutical compositions and methods of using the compounds are also disclosed.
    Type: Grant
    Filed: April 19, 2017
    Date of Patent: January 8, 2019
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: John D. Lambris, Hongchang Qu, Daniel Ricklin
  • Patent number: 10174120
    Abstract: The present invention provides methods of treating and enhancing efficacy of immunotherapy for a solid tumor in a subject, comprising the step of contacting the subject with a compound or composition that modulates the expression or activity of ETRB, ET-1, ICAM-1, or another protein found herein to play a role in homing of T cells to a solid tumor. The present invention also provides methods of prognosticating a solid tumor in a subject, comprising the step of measuring an expression level of a protein found herein to play a role in homing of T cells to a solid tumor, or a nucleotide molecule encoding same.
    Type: Grant
    Filed: January 20, 2016
    Date of Patent: January 8, 2019
    Assignee: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
    Inventors: Ronald J Buckanovich, George Coukos, Andrea Facciabene