Patents Assigned to The Trustees of the University of Pennsylvania
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Patent number: 11607125Abstract: A method for non-invasive assessment of photoreceptor function in a mammalian subject comprises exposing a subject's eye to a visible light stimulus to initiate an intrinsic reflectance response in one or a population of photoreceptors and capturing multiple images of photoreceptor's intrinsic reflectance response to the stimulus. Patterns of variability in the intrinsic reflectance response of a single photoreceptor or population of photoreceptors are useful in diagnosis and treatment monitoring of an ocular condition, disease, disorder or a response to treatment for said ocular condition, disease or disorder.Type: GrantFiled: April 20, 2019Date of Patent: March 21, 2023Assignee: The Trustees of the University of PennsylvaniaInventors: Jessica I. W. Morgan, David H. Brainard, Robert F. Cooper, William S. Tuten
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Patent number: 11609159Abstract: The present subject matter relates to systems, devices, and methods for agricultural sample collection. In one aspect, a sample collection system includes an aerial robotic platform, an arm assembly coupled to the aerial robotic platform and comprising an arm that extends away from the aerial robotic platform, and a sample collector connected to a distal end of the arm, wherein the sample collector is configured to selectively remove one or more samples of agricultural material from a plant to be analyzed.Type: GrantFiled: May 8, 2018Date of Patent: March 21, 2023Assignee: The Trustees of the University of PennsylvaniaInventors: Daniel Orol, Lukas Vacek, Delaney Vanessa Kaufman, Jnaneshwar Das, R. Vijay Kumar
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Publication number: 20230076977Abstract: The present invention provides methods for increasing expression of utrophin in a subject in need thereof, the method comprising administering to the subject a pharmaceutical composition comprising a post-transcriptionally utrophin upregulator compound. The present invention also provides methods for treating a subject having a muscular dystrophy. This invention further provides methods for high-throughput screening for a post-transcriptional utrophin upregulator compound.Type: ApplicationFiled: January 14, 2021Publication date: March 9, 2023Applicants: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, University of Pittsburgh - Of the Commonwealth System of Higher EducationInventors: Tejvir S. KHURANA, Donna M. HURYN
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Publication number: 20230070731Abstract: Compositions and methods for small molecule control of precise base editing are disclosed.Type: ApplicationFiled: January 20, 2021Publication date: March 9, 2023Applicant: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIAInventors: Rahul Kohli, Junwei Shi, Kiara Berrios
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Patent number: 11597778Abstract: The present invention relates to compositions and methods of use of anti-ADAMTS13 autoantibodies and fragments thereof. In one aspect, the invention includes a composition comprising an isolated anti-ADAMTS13 autoantibody or fragment thereof. In other aspects, methods are described for generating an in vivo model of thrombotic thrombocytopenic purpura (TTP) comprising introducing at least one anti-ADAMTS13 autoantibody or fragment thereof into a model organism and identifying an anti-autoimmune reagent for treating TTP.Type: GrantFiled: April 6, 2016Date of Patent: March 7, 2023Assignee: The Trustees of the University of PennsylvaniaInventors: Donald L. Siegel, Stephen Kacir, Eric Ostertag, X. Long Zheng
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Patent number: 11597911Abstract: This invention relates, inter alia, to compositions of low serum or serum free media and methods for the expansion of T cell populations and methods for using such populations of cells. In some aspects, the invention relates to compositions and methods for the selective expansion of T cell subpopulations.Type: GrantFiled: February 26, 2018Date of Patent: March 7, 2023Assignees: Life Technologies Corporation, The Trustees of the University of PennsylvaniaInventors: Angel M. Varela-Rohena, Melanie B. Andolina, James L. Riley, Andrew Medvec
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Patent number: 11596679Abstract: The present disclosure relates to compositions and methods for inducing an adaptive immune response against Hepatitis C virus (HCV) in a subject. In some embodiments, the present disclosure provides a composition comprising a nucleic acid molecule encoding a HCV antigen, an HCV antigen, an adjuvant, or a combination thereof. For example, in some embodiments, the composition comprises a vaccine comprising a nucleic acid molecule encoding a HCV antigen, an HCV antigen, an adjuvant, or a combination thereof.Type: GrantFiled: April 27, 2018Date of Patent: March 7, 2023Assignees: VANDERBILT UNIVERSITY, THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, THE JOHNS HOPKINS UNIVERSITYInventors: James E. Crowe, Jr., Andrew Flyak, Justin Bailey, Stuart Ray, George Shaw
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Patent number: 11596636Abstract: The present invention provides compositions and methods for treating and preventing cancer. The invention comprises an inhibitor of epigenetic regulators, including MLL1, MLL2, MOZ, menin, WDR5, or a combination thereof. In one embodiment, the invention provides a personalized method of treating a cancer as dependent upon its epigenetic signature.Type: GrantFiled: January 14, 2015Date of Patent: March 7, 2023Assignee: The Trustees of the University of PennsylvaniaInventors: Shelley L. Berger, Xianxin Hua, Morgan Sammons, Jiajun Zhu
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Patent number: 11597754Abstract: The present invention provides compositions and methods for treating cancer in a human. The invention includes relates to administering a genetically modified T cell expressing a CAR having an antigen binding domain, a transmembrane domain, a CD2 signaling domain, and a CD3 zeta signaling domain. The invention also includes incorporating CD2 into the CAR to alter the cytokine production of CAR-T cells in both negative and positive directions.Type: GrantFiled: July 2, 2019Date of Patent: March 7, 2023Assignee: The Trustees of the University of PennsylvaniaInventors: Carl H. June, John Scholler, Avery D. Posey, Jr.
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Patent number: 11596678Abstract: Nucleic acid molecules and compositions comprising one or more nucleic acid sequences that encode a consensus Marburgvirus filovirus glycoprotein immunogens. Immunomodulatory methods and methods of inducing an immune response against Marburgvirus are disclosed. Method of preventing infection by Marburgvirus and methods of treating individuals infected with Marburgvirus are disclosed. Consensus Marburgvirus filovirus glycoprotein immunogens are disclosed.Type: GrantFiled: December 1, 2017Date of Patent: March 7, 2023Assignees: The Trustees of the University of Pennsylvania, The Wistar Institute of Anatomv and BiologvInventors: David Weiner, Ami Patel, Sarah Elliott
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Patent number: 11591404Abstract: The invention provides compositions and methods for treating diseases associated with expression of CD123. The invention also relates to chimeric antigen receptor (CAR) specific to CD123, vectors encoding the same, and recombinant cells comprising the CD123 CAR. The invention also includes methods of administering a genetically modified cell expressing a CAR that comprises a CD123 binding domain.Type: GrantFiled: May 27, 2020Date of Patent: February 28, 2023Assignees: Novartis AG, The Trustees of the University of PennsylvaniaInventors: Jennifer Brogdon, Saar Gill, David Jonathan Glass, Saad Kenderian, Andreas Loew, Joan Mannick, Michael C. Milone, Leon Murphy, David L. Porter, Marco Ruella, Yongqiang Wang, Qilong Wu, Jiquan Zhang
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Patent number: 11591614Abstract: Provided herein are methods and compositions for treatment of Batten disease. Such compositions include a recombinant adeno-associated virus (rAAV), said rAAV comprising an AAV capsid, and a vector genome packaged therein, said vector genome comprising (a) an AAV 5? inverted terminal repeat (ITR) sequence; (b) a promoter; (c) a CLN2 coding sequence encoding a human TPP1; (d) an AAV 3? ITR.Type: GrantFiled: May 11, 2018Date of Patent: February 28, 2023Assignee: The Trustees of the University of PennsylvaniaInventors: James M. Wilson, Nathan Katz, Christian Hinderer, Juliette Hordeaux
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Patent number: 11591298Abstract: The present invention relates to novel bisaminoquinoline compounds, pharmaceutical compositions comprising these novel compounds and methods for inhibiting autophagy in biological systems. Methods of treating cancer in patients in need using compounds and/or compositions according to the present invention alone or in combination with at least one additional anticancer agent represent additional aspects of the invention. Methods of treating disease states and/or conditions in which inhibition of autophagy plays a favorable treatment role including rheumatoid arthritis, malaria, antiphospholipid antibody syndrome, lupus, chronic urticaria and Sjogren's disease, with compounds according to the present invention represent additional aspects of the invention.Type: GrantFiled: February 26, 2019Date of Patent: February 28, 2023Assignee: The Trustees of the University of PennsylvaniaInventors: Ravi K. Amaravadi, Jeffrey Winkler
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Patent number: 11584937Abstract: The invention relates to molecules for controlling plant growth and development. Specifically, the invention relates to molecules comprising a gibberellin activator or a gibberellin inhibitor operably linked to a promoter specific to a lateral organ primordium. The invention also relates to transgenic plants having the transgenic molecules and methods for making such transgenic plants.Type: GrantFiled: April 28, 2015Date of Patent: February 21, 2023Assignee: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIAInventors: Doris Wagner, Nobutoshi Yamaguchi
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Publication number: 20230046047Abstract: The invention relates to antibody conjugates (e.g., a bispecific antibody), drug and nanoparticle compositions and methods and compositions for generating them. This invention further relates to methods of using these compositions for imaging, diagnosing or treating a disease.Type: ApplicationFiled: August 25, 2021Publication date: February 16, 2023Applicant: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIAInventors: Andrew Tsourkas, James Z. Hui
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Patent number: 11578341Abstract: A rAAV vector is described herein which has an AAVhu68 capsid and at least one expression cassette in the capsid. The at least one expression cassette comprises nucleic acid sequences encoding a functional SMN protein and expression control sequences that direct expression of the SMN sequences in a host cell. Also provided are compositions containing this rAAVhu68.SMN vector and methods of using same for spinal muscular atrophy in a patient.Type: GrantFiled: February 27, 2018Date of Patent: February 14, 2023Assignee: The Trustees of the University of PennsylvaniaInventors: James M. Wilson, Christian Hinderer, Nathan Katz, Qiang Wang
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Patent number: 11581501Abstract: An electronic device and a production method thereof, wherein the electronic device includes: a semiconductor layer comprising a plurality of quantum dots; and a first electrode and a second electrode spaced apart from each other; wherein the plurality of quantum dots do not comprise cadmium, lead, or mercury; wherein the plurality of quantum dots comprise indium and optionally gallium; a Group VA element, wherein the Group VA element comprises antimony, arsenic, or a combination thereof, and a molar ratio of the Group VA element with respect to the Group IIIA metal (e.g., indium) is less than or equal to about 1.2:1, and wherein the semiconductor layer may be disposed between the first electrode and the second electrode.Type: GrantFiled: June 14, 2019Date of Patent: February 14, 2023Assignees: SAMSUNG ELECTRONICS CO., LTD., THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIAInventors: Tae Gon Kim, Tianshuo Zhao, Nuri Oh, Cherie Kagan, Eun Joo Jang, Christopher Murray
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Patent number: 11578137Abstract: This invention relates to inhibition of the complement signaling using an anti-C5 antibody. Specifically, the invention relates to methods of treating a complement-mediated disease or complement-mediated disorder in an individual by contacting the individual with an anti-C5 antibody.Type: GrantFiled: March 6, 2018Date of Patent: February 14, 2023Assignee: The Trustees of the University of PennsylvaniaInventors: Wenchao Song, Sayaka Sato, Takashi Miwa, Damodar Gullipalli
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Patent number: 11578130Abstract: Compositions and methods relating to regulatable chimeric antigen receptors (RCARs), where the intracellular signaling or proliferation of the RCAR can be controlled to optimize the use of an RCAR-expressing cell to provide an immune response, are provided. For example, a RCAR can comprise a dimerization switch that, upon the presence of a dimerization molecule, can couple an intracellular signaling domain to an extracellular recognition element, e.g., an antigen binding domain, an inhibitory counter ligand binding domain, or costimulatory ECD domain. An RCAR can be engineered to include an appropriate antigen binding domain that is specific to a desired antigen target and used in the treatment of a disease.Type: GrantFiled: December 5, 2018Date of Patent: February 14, 2023Assignees: Novartis AG, The Trustees of the University of PennsylvaniaInventors: Jennifer Brogdon, Boris Engels, David Jonathan Glass, Brian Granda, John Hastewell, Andreas Loew, Joan Mannick, Michael C. Milone, Leon Murphy, William Raj Sellers, Huijuan Song, Brian Edward Vash, Jan Weiler, Qilong Wu, Li Zhou
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Patent number: 11578113Abstract: The invention includes compositions comprising at least one chimeric autoantibody receptor (CAAR) specific for an autoantibody, vectors comprising the same, compositions comprising CAAR vectors packaged in viral particles, and recombinant T cells comprising the CAAR. The invention also includes methods of making a genetically modified T cell expressing a CAAR (CAART) wherein the expressed CAAR comprises a desmoglein extracellular domain.Type: GrantFiled: April 22, 2019Date of Patent: February 14, 2023Assignee: The Trustees of the University of PennsylvaniaInventors: Aimee S. Payne, Christoph T. Ellebrecht, Vijay Bhoj, Michael C. Milone