Abstract: Provided herein are novel AAV capsids and recombinant AAV vectors comprising the same. In certain embodiment, vectors comprising a novel AAV capsid show improved transduction of cardiac tissue and/or reduced targeting of liver tissue compared to a prior art AAV capsid.
Type:
Application
Filed:
January 24, 2023
Publication date:
May 8, 2025
Applicant:
The Trustees of the University of Pennsylvania
Abstract: The present disclosure provides gene edited modified immune cells or precursors thereof (e.g., gene edited modified T cells) comprising an exogenous T cell receptor (TCR) and/or a chimeric antigen receptor (CAR) having specificity for a target antigen, and an insertion and/or deletion in one or more endogenous gene loci, wherein the endogenous gene loci encode regulators of T cell function, thereby resulting in immune cells having enhanced function. Compositions and methods of treatment are also provided. The present invention provides methods of screening for TCR- or CAR-T cells with enhanced immune function (e.g., T cell efficacy, T cell memory, and/or T cell persistence).
Type:
Grant
Filed:
January 29, 2024
Date of Patent:
May 6, 2025
Assignee:
The Trustees of the University of Pennsylvania
Abstract: The presently disclosed subject matter provides a biomimetic lung disease model, and methods of its production and use. In one exemplary embodiment, the biomimetic lung disease model can include a first and second microchannel with a membrane coated with airway epithelial cells disposed between the microchannels and at least one device coupled to the biomimetic model that delivers an agent to at least one microchannel. In certain embodiments, the agent is cigarette smoke.
Type:
Grant
Filed:
October 11, 2023
Date of Patent:
May 6, 2025
Assignee:
The Trustees of the University of Pennsylvania
Inventors:
Dongeun Huh, Mark Mondrinos, Woo Yul Byun
Abstract: Compounds and methods of treating HIV-1 in a human infected with HIV-1 or preventing HIV-1 infection in a human susceptible to infection with HIV-1 are provided. The compounds are of formula (I), (II), and (IA), wherein R1-R7, X, X?, Y, Y?, Z, and n are defined herein, and the methods comprises administering therapeutically effective amounts of these compounds to the human.
Type:
Grant
Filed:
July 31, 2019
Date of Patent:
April 29, 2025
Assignees:
THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, VAL-CHUM, LIMITED PARTNERSHIP
Inventors:
Melissa Carey Davies, Amos B. Smith, III, Andres Finzi, Shilei Ding, Jean-Philippe Chapleau
Abstract: The present disclosure relates to ionizable lipidoid compounds comprising an anisamide moiety, and lipid nanoparticles (LNPs) comprising the same. In certain embodiments, the LNP selectively binds to at least one sigma receptor. In certain embodiments, the LNP specifically targets a cell of interest (e.g., a cell expressing a sigma receptor, fibroblast, cancer cell, stromal cell, and epithelial cell, inter alia). In another aspect, the present disclosure provides methods for in vivo delivery of therapeutic agents to treat, prevent, and/or ameliorate diseases and/or disorders, including but not limited to fibrosis and cancer.
Type:
Application
Filed:
December 6, 2022
Publication date:
April 24, 2025
Applicant:
The Trustees Of The University Of Pennsylvania
Abstract: Provided are systems and methods for tagging biomolecules of interest, methods of generating tagged biomolecules, and methods of use thereof. An adapter system comprises one or more epitope tags operably linked to an antibody binding domain (AbBD), which may be a photoreactive antibody binding domain (pAbBD). A pAbBD may be used to covalently photocrosslink epitope tags to immunoglobulins or immunoglobulin fragments, which may in turn be used to label biomolecules of interest. Such epitope-tagged immunoglobulins may be used in various biological research applications, including multiplexed staining assays and tandem affinity pulldown assays.
Type:
Application
Filed:
August 3, 2022
Publication date:
April 24, 2025
Applicants:
THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, ALPHATHERA LLC
Abstract: The present invention relates to compositions and methods for treating diseases, disorders or conditions associated with the expression of the glycosyl-phosphatidylinositol (GPI)-linked GDNF family protein ?-receptor 4 (GFR?4).
Type:
Grant
Filed:
September 27, 2023
Date of Patent:
April 22, 2025
Assignees:
The Trustees of the University of Pennsylvania, University of Florida Research Foundation, Incorporated
Inventors:
Donald L. Siegel, Vijay Bhoj, Christoph Rader, Rebecca Goydel
Abstract: The invention includes a vaccine comprising an antigen and IL-21. The invention also includes methods for increasing an immune response in a subject. The methods may comprise administering the vaccine to the subject in need thereof.
Type:
Grant
Filed:
April 15, 2021
Date of Patent:
April 22, 2025
Assignees:
The Trustees of the University of Pennsylvania, Inovio Pharmaceuticals, Inc.
Abstract: The present invention provides a mutant protein which has the same amino acid sequence of a wild type PF4 monomer except that (i) at least one amino acid of the wild type PF4 monomer has been deleted, (ii) at least one amino acid of the wild type PF4 monomer has been replaced by another amino acid, or (iii) a combination of such changes has been made. The present invention also provides methods of treating or reducing the likelihood of HIT, treating angiogenesis, treating abnormal cell growth, or affecting coagulation pathologies that lead to thrombus formation, by administering such mutant proteins to a patient.
Type:
Grant
Filed:
January 23, 2024
Date of Patent:
April 22, 2025
Assignee:
The Trustees of the University of Pennsylvania
Inventors:
Mark I. Greene, Douglas B. Cines, Zheng Cai, Zhiqiang Zhu
Abstract: This present disclosure relates to the use of donor organ-derived microvesicles to monitor the status of a transplanted organ in a subject. Accordingly, this disclosure provides for methods and kits for isolating, purifying and/or identifying donor organ-derived microvesicles from a biological sample of a subject. In certain embodiments, a method for isolating, purifying and/or identifying donor organ-derived microvesicles includes obtaining a biological sample from the subject and isolating, purifying or identifying a donor organ-derived microvesicle from the biological sample by the detection of a protein specific for the donor.
Type:
Application
Filed:
December 18, 2024
Publication date:
April 10, 2025
Applicant:
THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
Abstract: This invention relates to conjugate antibody, drug and nanoparticle compositions and methods of generating the same. This invention further relates to methods of using same for imaging, diagnosing or treating a disease.
Type:
Grant
Filed:
October 22, 2021
Date of Patent:
April 8, 2025
Assignee:
THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
Abstract: Nucleic acid molecules and compositions comprising one or more nucleic acid sequences that encode a consensus Marburgvirus filovirus glycoprotein immunogens. Immunomodulatory methods and methods of inducing an immune response against Marburgvirus are disclosed. Method of preventing infection by Marburgvirus and methods of treating individuals infected with Marburgvirus are disclosed. Consensus Marburgvirus filovirus glycoprotein immunogens are disclosed.
Type:
Grant
Filed:
March 7, 2023
Date of Patent:
April 8, 2025
Assignees:
The Wistar Institute of Anatomy and Biology, The Trustees of the University of Pennsylvania
Abstract: A portable pupillometer for evaluating one or more pupils of a subject includes an optical assembly to stimulate the one or more pupils. The optical assembly has a light source to deliver a stimulus to the one or more pupils and a detector to capture images of the one or more pupils during delivery of the stimulus. A control device is coupled to the optical assembly, which has a controller to perform a plurality of operations in accordance with instructions stored in a digital memory. The plurality of operations includes: obtaining pupillary light reflex data comprising a plurality of Pupillary Light Reflex metrics during stimulation of the one or more pupils; analyzing the pupillary light reflex data based on one or more characteristics of the subject; determining a probability of a concussion injury suffered by the subject; and outputting the probability to a user of the pupillometer.
Type:
Application
Filed:
September 3, 2024
Publication date:
March 20, 2025
Applicants:
The Children's Hospital of Philadelphia, The Trustees of the University of Pennsylvania
Inventors:
Kristy B. Arbogast, Christina L. Master, Daniel Corwin, Matthew Grady, Catherine McDonald, Francesca Mandell, Ian Barnett
Abstract: Systems and methods for achieving levitation via a photophoretic effect are provided. In certain embodiments, a structure of ultralight materials is provided, for example a BoPET film and carbon nanotubes and has a top and bottom side, made of two separate materials. When the bottom side is illuminated by light at certain intensity, it can result in an upward lift force being applied to the entire structure, causing the structure to levitate.
Type:
Grant
Filed:
May 12, 2022
Date of Patent:
March 18, 2025
Assignee:
The Trustees of the University of Pennsylvania
Inventors:
Igor Bargatin, Zhipeng Lu, Mohsen Azadi
Abstract: Embodiments of the present invention relate to mechanically-activated microcapsules (MAMCs) for controlled drug-delivery, wherein the MAMCs release one or more active ingredients in response to mechanical stimuli in a subject's body. The MAMCs provide a platform for stimulating biological regeneration, biological repair, modifying disease, and/or controlling disease in mechanically-loaded musculoskeletal tissues.
Type:
Grant
Filed:
August 3, 2022
Date of Patent:
March 18, 2025
Assignee:
The Trustees of the University of Pennsylvania
Inventors:
Daeyeon Lee, Robert Leon Mauck, George R Dodge, Fuquan Tu, Bhavana Mohanraj
Abstract: A method for generating and providing artificial intelligence assisted surgical guidance includes analyzing video images from surgical procedure and training a neural network to identify at least one of anatomical objects, surgical objects, and tissue manipulation in video images. The method includes receiving, by the neural network, a live feed of video images from the surgery. The method further includes classifying, by the neural network, at least one of anatomical objects, surgical objects, and tissue manipulation in the live feed of video images. The method further includes outputting, in real time, surgical guidance based on algorithms created using the classified at least on of anatomical objects, surgical objects, and tissue manipulations in the live feed of video images.
Type:
Grant
Filed:
July 25, 2019
Date of Patent:
March 11, 2025
Assignee:
THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
Inventors:
Vivek Paresh Buch, Peter John Madsen, Jianbo Shi
Abstract: Methods and apparatus for improving cognitive function within a human. The invention utilizes a neurostimulation device, such as a signal generator, to affect tissue elements at a lateral temporal lobe of the human brain. The implanted device delivers treatment therapy to thereby improve cognitive function by the human. A sensor may be used to detect various characteristics of cognition. A microprocessor algorithm may then analyze the output from the sensor to regulate delivery of the stimulation therapy.
Type:
Application
Filed:
July 8, 2024
Publication date:
March 6, 2025
Applicant:
The Trustees of the University of Pennsylvania
Abstract: The invention provides methods of making immune effector cells (e.g., T cells, NK cells) that can be engineered to express a chimeric antigen receptor (CAR), compositions and reaction mixtures comprising the same, and methods of treatment using the same.
Type:
Grant
Filed:
September 18, 2020
Date of Patent:
March 4, 2025
Assignees:
Novartis AG, The Trustees of the University of Pennsylvania
Inventors:
Felipe Bedoya, Saba Ghassemi, Carl H. June, Omkar U. Kawalekar, Bruce L Levine, Jan J. Melenhorst, Michael C. Milone, Daniel J. Powell, Jr., Zoe Zheng
Abstract: Nucleic acid molecules and compositions comprising one or more nucleic acid sequences that encode a consensus Ebolavirus glycoproteinimmunogens are disclosed. The coding sequences optionally include operable linked coding sequence that encode a signal peptide. Immunomodulatory methods and methods of inducing an immune response against Ebolavirus are disclosed. Method of preventing Ebolavirus and methods of treating individuals infected with Ebolavirus are disclosed. Consensus Ebolavirus proteins are disclosed.
Type:
Grant
Filed:
August 17, 2021
Date of Patent:
March 4, 2025
Assignees:
The Trustees of the University of Pennsylvania, The Wistar Institute of Anatomy and Biology, Inovio Pharmaceuticals, Inc.