Patents Assigned to The Trustees of the University of Pennsylvania
  • Publication number: 20180221239
    Abstract: Gait rehabilitation systems, methods, and apparatuses thereof are disclosed. In accordance with one aspect of the invention, a gait rehabilitation system may include a harness configured for attachment to an individual and at least one sensor configured to sense at least one parameter associated with gait of an individual, the individual having an affected leg and an unaffected leg. The system includes a braking system configured for attachment to the harness and in communication with the at least one sensor. The braking system is further configured for monitoring the at least one sensor to sense the at least one parameter associated with an individual's gait, determining when the affected leg is in a modification portion of the individual's gait from the sensed at least one parameter, and applying a braking force resisting movement of the harness during the determined modification portion.
    Type: Application
    Filed: August 5, 2016
    Publication date: August 9, 2018
    Applicants: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, THE STATE UNIVERSITY OF NEW YORK
    Inventors: Katherine J. KUCHENBECKER, Vivienne CLAYTON, Ilana TEICHER, Siyao HU, Erin VASUDEVAN
  • Publication number: 20180223251
    Abstract: The presently disclosed subject matter provides an approach to address the needs for microscale control in shaping the spatial geometry and microarchitecture of 3D collagen hydrogels. For example, the disclosed subject matter provides for compositions, methods, and systems employing N-sulfosuccinimidyl-6-(4?-azido-2?-nitro-phenylamino)hexanoate (“sulfo-SANPAH”), to prevent detachment of the hydrogel from the anchoring substrate due to cell-mediated contraction.
    Type: Application
    Filed: July 27, 2016
    Publication date: August 9, 2018
    Applicant: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
    Inventors: Dongeun Huh, Mark Mondrinos, Cassidy Blundell, Jeongyun Seo
  • Patent number: 10041090
    Abstract: Adeno-associated virus rh.8 sequences, vectors containing same, and methods of use are provided.
    Type: Grant
    Filed: December 2, 2015
    Date of Patent: August 7, 2018
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: Guangping Gao, James M. Wilson, Mauricio R. Alvira
  • Patent number: 10040846
    Abstract: The present invention provides compositions and methods for generating a genetically modified T cells comprising a chimeric antigen receptor (CAR) having an antigen binding domain, a transmembrane domain, a costimulatory signaling region, and a CD3 zeta signaling domain, wherein the T cell exhibits prolonged exponential expansion in culture that is ligand independent and independent of the addition of exogenous cytokines or feeder cells.
    Type: Grant
    Filed: February 22, 2013
    Date of Patent: August 7, 2018
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: Matthew J. Frigault, Yangbing Zhao, John Scholler, Carl H. June
  • Patent number: 10040828
    Abstract: Nucleic acid molecules and compositions comprising one or more nucleic acid sequences that encode an RSV immunogen are disclosed. Nucleic acid are disclosed that comprise the sequences that encodes consensus RSV F protein or immunogenic fragment thereof, sequences that encodes an RSV G(A) protein or immunogenic fragment thereof and sequences that encodes an RSV G(B) protein or immunogenic fragment thereof. Compositions comprising one, combinations of two or all three sequences are disclosed. The coding sequences optionally include operable linked coding sequence that encode a signal peptide. Nucleic acid molecules and compositions comprising the chemokine CC20 and/or a consensus RSV M2-1 protein or immunogenic fragment thereof are also disclosed. Immunomodulatory methods and methods of inducing an immune response against RSV are disclosed. Method of preventing RSV infection and methods of treating individuals infected with RSV are disclosed.
    Type: Grant
    Filed: April 10, 2013
    Date of Patent: August 7, 2018
    Assignee: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
    Inventors: David B. Weiner, Daniel Choo, Karuppiah Muthumani, Nyamekye Obeng-Adjei, Veronica Scott
  • Patent number: 10043250
    Abstract: Interactive non-uniformity correction (NC) and interactive intensity standardization (IS) require sample tissue regions to be specified for several different types of tissues. Interactive NC estimates the degree of non-uniformity at each voxel in a given image, builds a global function for non-uniformity correction, and then corrects the image to improve quality. Interactive IS includes two steps: a calibration step and a transformation step. In the first step, tissue intensity signatures of each tissue from a few subjects are utilized to set up key landmarks in a standardized intensity space. In the second step, a piecewise linear intensity mapping function is built between the same tissue signatures derived from the given image and those in the standardized intensity space to transform the intensity of the given image into standardized intensity. Interactive IS for MR images combined with interactive NC can substantially improve numeric characterization of tissues.
    Type: Grant
    Filed: March 25, 2016
    Date of Patent: August 7, 2018
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: Jayaram K. Udupa, Dewey Odhner, Yubing Tong, Drew A. Torigian
  • Patent number: 10040859
    Abstract: Compositions and methods for treating a cytokine release syndrome such as chimeric antigen receptor T-cell cytokine release syndrome or hemophagocytic lymphohistiocytosis are provided.
    Type: Grant
    Filed: April 21, 2015
    Date of Patent: August 7, 2018
    Assignees: The Children's Hospital of Philadelphia, The Trustees of the University of Pennsylvania
    Inventors: Edward M. Behrens, Julia E. Rood, Taku Kambayashi
  • Publication number: 20180217142
    Abstract: The invention relates to methods for providing prognosis, diagnosis, monitoring and treatment of a mild traumatic brain injury (mTBI) in a subject, including a sports-related concussion. The invention further relates to assessing the severity of brain damage resulting from mTBI in a subject, including in a subject who has not undergone a CT scan following the injury. For example, the methods of the invention can be used to determine the suitability for someone who has suffered a sports-related injury to return to play that sport. This invention also relates to methods of predicting risk for developing brain damage and long-term dysfunction in a subject having suffered mTBI.
    Type: Application
    Filed: March 23, 2018
    Publication date: August 2, 2018
    Applicant: The Trustees of the University of Pennsylvania
    Inventor: Robert Siman
  • Publication number: 20180216058
    Abstract: The presently disclosed subject matter provides a biomimetic lung disease model, and methods of its production and use. In one exemplary embodiment, the biomimetic lung disease model can include a first and second microchannel with a membrane coated with airway epithelial cells disposed between the microchannels and at least one device coupled to the biomimetic model that delivers an agent to at least one microchannel. In certain embodiments, the agent is cigarette smoke.
    Type: Application
    Filed: July 27, 2016
    Publication date: August 2, 2018
    Applicant: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
    Inventors: Dongeun Huh, Mark Mondrinos, Woo Yul Byun
  • Patent number: 10034930
    Abstract: Nucleic acid molecules and compositions comprising one or more nucleic acid sequences that encode a consensus filovirus immunogen including a consensus Marburgvirus filovirus glycoprotein MARV GP immunogen, a consensus Ebolavirus Sudan filovirus glycoprotein SEBOV GP immunogen and a consensus Ebolavirus Zaire glycoprotein ZEBOV GP immunogen are disclosed. The coding sequences optionally include operable linked coding sequence that encode a signal peptide. Immunomodulatory methods and methods of inducing an immune response against filovirus, particularly Marburgvirus, Ebolavirus Sudan and Ebolavirus Zaire are disclosed. Method of preventing filovirus infection, particularly infection by Marburgvirus, Ebolavirus Sudan and Ebolavirus Zaire and methods of treating individuals infected with filovirus infection, particularly infection by Marburgvirus, Ebolavirus Sudan and Ebolavirus Zaire are disclosed. Consensus filovirus proteins are disclosed.
    Type: Grant
    Filed: February 13, 2017
    Date of Patent: July 31, 2018
    Assignee: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
    Inventors: David B. Weiner, Devon Shedlock
  • Patent number: 10037028
    Abstract: Systems, devices, and methods for on-board sensing and control of robotic vehicles (e.g., MAVs) using commercial off-the-shelf hand-held electronic devices as a sensing and control system are provided. In one aspect, a system for controlling a micro aerial vehicle may include one or more sensors, a state estimation module in communication with the one or more sensors, the state estimation module being configured to generate an estimated pose of the micro aerial vehicle based on inputs from the one or more sensors, and a position controller in communication with the state estimation module and configured to communicate attitude commands to an attitude controller of the micro aerial vehicle. Each of the one or more sensors, the state estimation module, and the position controller may be contained in a commercial off-the-shelf hand-held electronic device that is configured to be coupled to the micro aerial vehicle.
    Type: Grant
    Filed: July 25, 2016
    Date of Patent: July 31, 2018
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: Giuseppe Loianno, Yash Shailesh Mulgaonkar, R. Vijay Kumar
  • Publication number: 20180210007
    Abstract: The presently disclosed subject matter provides systems and methods for generating nanostructures from tribological films. A probe tip can be immersed in a liquid mixture comprising a plurality of ink particles suspended in a medium. A substrate on which the tribological film is to be generated can also be immersed in the liquid mixture. A processor controlling movement of the probe tip can be configured to cause the probe tip to slide along the substrate in a shape of a desired pattern of the nanostructure with a contact force to cause one or more ink particles of the plurality of ink particles compressed underneath the probe tip to be transformed into a tribological film onto the substrate in the shape of the desired pattern of the nanostructure.
    Type: Application
    Filed: August 29, 2016
    Publication date: July 26, 2018
    Applicant: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
    Inventors: Robert W. Carpick, Harmandeep S. Khare, Nitya Nand Gosvami, Imene Lahouij
  • Publication number: 20180209975
    Abstract: This present disclosure relates to the use of donor organ-derived microvesicles to monitor the status of a transplanted organ in a subject. Accordingly, this disclosure provides for methods and kits for isolating, purifying and/or identifying donor organ-derived microvesicles from a biological sample of a subject. In certain embodiments, a method for isolating, purifying and/or identifying donor organ-derived microvesicles includes obtaining a biological sample from the subject and isolating, purifying or identifying a donor organ-derived microvesicle from the biological sample by the detection of a protein specific for the donor.
    Type: Application
    Filed: March 23, 2018
    Publication date: July 26, 2018
    Applicant: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
    Inventors: Prashanth Vallabhjosyula, Douglas Taylor
  • Patent number: 10032635
    Abstract: The disclosed subject matter provides thin films including a metal silicide and methods for forming such films. The disclosed subject matter can provide techniques for tailoring the electronic structure of metal thin films to produce desirable properties. In example embodiments, the metal silicide can comprise a platinum silicide, such as for example, PtSi, Pt2Si, or Pt3Si. For example, the disclosed subject matter provides methods which include identifying a desired phase of a metal silicide, providing a substrate, depositing at least two film layers on the substrate which include a first layer including amorphous silicon and a second layer including metal contacting the first layer, and annealing the two film layers to form a metal silicide. Methods can be at least one of a source-limited method and a kinetically-limited method. The film layers can be deposited on the substrate using techniques known in the art including, for example, sputter depositing.
    Type: Grant
    Filed: January 27, 2016
    Date of Patent: July 24, 2018
    Assignee: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
    Inventors: Robert W. Carpick, Frank Streller, Rahul Agarwal, Filippo Mangolini
  • Patent number: 10030040
    Abstract: The invention relates to processes for preparing (S,S)-secoisolariciresinol diglucoside and (R,R)-secoisolariciresinol diglucoside and compositions comprising the same.
    Type: Grant
    Filed: June 10, 2014
    Date of Patent: July 24, 2018
    Assignee: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
    Inventors: Melpo Christofidou-Solomidou, Kyriacos C. Nicolaou, Roman A. Valiulin, Nicholas Simmons, Philipp M. Heretsch
  • Patent number: 10022434
    Abstract: Provided herein are nucleic acid sequences that encode novel consensus amino acid sequences of HA hemagglutinin and/or influenza B hemagglutinin, as well as genetic constructs/vectors and vaccines expressing the sequences. Also provided herein are methods for generating an immune response against one or more influenza A serotypes and/or influenza B serotypes, or combinations thereof, using the vaccines that are provided.
    Type: Grant
    Filed: March 12, 2014
    Date of Patent: July 17, 2018
    Assignee: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
    Inventors: David B. Weiner, Jian Yan, Matthew Morrow
  • Patent number: 10017813
    Abstract: Provided are solid-state nanopore platforms for fast, electronic, label-free and high-resolution analysis of biomolecules.
    Type: Grant
    Filed: March 26, 2014
    Date of Patent: July 10, 2018
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: Marija Drndic, Kimberly Elizabeth Venta, Gabriel Shemer
  • Patent number: 10016404
    Abstract: The present invention provides methods and compositions for treating hyperlipidemia and/or hypercholesterolemia comprising administering to the subject an effective amount of an MTP inhibitor to inhibit hyperlipidemia and/or hypercholesterolemia in said subject, wherein said administration comprises an escalating series of doses of the MTP inhibitor. In some embodiments the method comprises administering at least three step-wise, increasing dosages of the MTP inhibitor to the subject. In some embodiments, the method further comprises the administration of one or more other lipid modifying compounds.
    Type: Grant
    Filed: May 25, 2017
    Date of Patent: July 10, 2018
    Assignee: The Trustees of the University of Pennsylvania
    Inventor: Daniel J. Rader
  • Patent number: 10020161
    Abstract: A method for irradiating a planning target volume with charged particles includes delivering the charged particles to the planning target volume with a charged particle therapy system including a charged particle beam path and a gantry configured to rotate about the planning target volume and to direct the charged particle beam path; rotating the gantry, during an irradiation session, to a plurality of positions; during the rotation, irradiating the planning target volume with the charged particles at a first energy level at one or more of the plurality of positions.
    Type: Grant
    Filed: July 20, 2015
    Date of Patent: July 10, 2018
    Assignee: The Trustees of the University of Pennsylvania
    Inventor: Alejandro Carabe-Fernandez
  • Patent number: 10016617
    Abstract: This invention provides methods for inducing an immune response against a Her-2/neu antigen-expressing tumor and for treating the same and vaccinating against the same in human and canine subjects using a combination of radiation therapy and a recombinant attenuated Listeria strain vaccine.
    Type: Grant
    Filed: March 26, 2015
    Date of Patent: July 10, 2018
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: Nicola Mason, Yvonne Paterson