ORGANIC ELECTROLUMINESCENT MATERIALS AND DEVICES

A composition including a first compound capable of functioning as a phosphorescent emitter in an OLED is provided. The first compound has at least one aromatic ring and at least one substituent R directly bonded to one of the at least one aromatic rings. Each substituent R has the formula of where (a) G1 is selected from NR1, SiR1R2, GeR1R2, alkyl, cycloalkyl, and combinations thereof; and G2 is a non-aromatic polycyclic group; (b) G1 is a direct bond; and G2 is a non-aromatic spiro polycyclic group; or (c) G1 is selected from direct bond, NR1, SiR1R2, GeR1R2, alkyl, cycloalkyl, and combinations thereof; G2 is a non-aromatic polycyclic group; and R is directly bonded to a phenyl, pyridine, or triazine. R1, R2, and R3 are are a variety of substituents. Formulations and devices, such as an OLEDs, that include the first compound are also described.

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Description
CROSS-REFERENCE TO RELATED APPLICATIONS

This application is a continuation of co-pending U.S. Pat. Application No. 16/438,819, filed on Jun. 12, 2019, which is a continuation of U.S. Pat. Application No. 15/240,044, filed on Aug. 18, 2016, which claims priority to U.S. Provisional applications No. 62/213,757, filed on Sep. 3, 2015; No. 62/232,194, filed on Sep. 24, 2015; No. 62/291,960, filed on Feb. 5, 2016; No. 62/322,510, filed on Apr. 14, 2016; and No. 62/330,412 filed on May 2, 2016, the entire contents of which are incorporated herein by reference.

PARTIES TO A JOINT RESEARCH AGREEMENT

The claimed invention was made by, on behalf of, and/or in connection with one or more of the following parties to a joint university corporation research agreement: The Regents of the University of Michigan, Princeton University, University of Southern California, and the Universal Display Corporation. The agreement was in effect on and before the date the claimed invention was made, and the claimed invention was made as a result of activities undertaken within the scope of the agreement.

FIELD

The present invention relates to compounds for use as emitters, and devices, such as organic light emitting diodes, including the same.

BACKGROUND

Opto-electronic devices that make use of organic materials are becoming increasingly desirable for a number of reasons. Many of the materials used to make such devices are relatively inexpensive, so organic opto-electronic devices have the potential for cost advantages over inorganic devices. In addition, the inherent properties of organic materials, such as their flexibility, may make them well suited for particular applications such as fabrication on a flexible substrate. Examples of organic opto-electronic devices include organic light emitting diodes/devices (OLEDs), organic phototransistors, organic photovoltaic cells, and organic photodetectors. For OLEDs, the organic materials may have performance advantages over conventional materials. For example, the wavelength at which an organic emissive layer emits light may generally be readily tuned with appropriate dopants.

OLEDs make use of thin organic films that emit light when voltage is applied across the device. OLEDs are becoming an increasingly interesting technology for use in applications such as flat panel displays, illumination, and backlighting. Several OLED materials and configurations are described in U.S. Pat. Nos. 5,844,363, 6,303,238, and 5,707,745, which are incorporated herein by reference in their entirety.

One application for phosphorescent emissive molecules is a full color display. Industry standards for such a display call for pixels adapted to emit particular colors, referred to as “saturated” colors. In particular, these standards call for saturated red, green, and blue pixels. Alternatively the OLED can be designed to emit white light. In conventional liquid crystal displays emission from a white backlight is filtered using absorption filters to produce red, green and blue emission. The same technique can also be used with OLEDs.The white OLED can be either a single EML device or a stack structure. Color may be measured using CIE coordinates, which are well known to the art.

One example of a green emissive molecule is tris(2-phenylpyridine) iridium, denoted Ir(ppy)3, which has the following structure:

In this, and later figures herein, we depict the dative bond from nitrogen to metal (here, Ir) as a straight line.

As used herein, the term “organic” includes polymeric materials as well as small molecule organic materials that may be used to fabricate organic opto-electronic devices. “Small molecule” refers to any organic material that is not a polymer, and “small molecules” may actually be quite large. Small molecules may include repeat units in some circumstances. For example, using a long chain alkyl group as a substituent does not remove a molecule from the “small molecule” class. Small molecules may also be incorporated into polymers, for example as a pendent group on a polymer backbone or as a part of the backbone. Small molecules may also serve as the core moiety of a dendrimer, which consists of a series of chemical shells built on the core moiety. The core moiety of a dendrimer may be a fluorescent or phosphorescent small molecule emitter. A dendrimer may be a “small molecule,” and it is believed that all dendrimers currently used in the field of OLEDs are small molecules.

As used herein, “top” means furthest away from the substrate, while “bottom” means closest to the substrate. Where a first layer is described as “disposed over” a second layer, the first layer is disposed further away from substrate. There may be other layers between the first and second layer, unless it is specified that the first layer is “in contact with” the second layer. For example, a cathode may be described as “disposed over” an anode, even though there are various organic layers in between.

As used herein, “solution processible” means capable of being dissolved, dispersed, or transported in and/or deposited from a liquid medium, either in solution or suspension form.

A ligand may be referred to as “photoactive” when it is believed that the ligand directly contributes to the photoactive properties of an emissive material. A ligand may be referred to as “ancillary” when it is believed that the ligand does not contribute to the photoactive properties of an emissive material, although an ancillary ligand may alter the properties of a photoactive ligand.

As used herein, and as would be generally understood by one skilled in the art, a first “Highest Occupied Molecular Orbital” (HOMO) or “Lowest Unoccupied Molecular Orbital” (LUMO) energy level is “greater than” or “higher than” a second HOMO or LUMO energy level if the first energy level is closer to the vacuum energy level. Since ionization potentials (IP) are measured as a negative energy relative to a vacuum level, a higher HOMO energy level corresponds to an IP having a smaller absolute value (an IP that is less negative). Similarly, a higher LUMO energy level corresponds to an electron affinity (EA) having a smaller absolute value (an EA that is less negative). On a conventional energy level diagram, with the vacuum level at the top, the LUMO energy level of a material is higher than the HOMO energy level of the same material. A “higher” HOMO or LUMO energy level appears closer to the top of such a diagram than a “lower” HOMO or LUMO energy level.

As used herein, and as would be generally understood by one skilled in the art, a first work function is “greater than” or “higher than” a second work function if the first work function has a higher absolute value. Because work functions are generally measured as negative numbers relative to vacuum level, this means that a “higher” work function is more negative. On a conventional energy level diagram, with the vacuum level at the top, a “higher” work function is illustrated as further away from the vacuum level in the downward direction. Thus, the definitions of HOMO and LUMO energy levels follow a different convention than work functions.

More details on OLEDs, and the definitions described above, can be found in U.S. Pat. No. 7,279,704, which is incorporated herein by reference in its entirety.

SUMMARY

According to one embodiment, a composition comprising a first compound is provided. In the composition, the first compound is capable of functioning as a phosphorescent emitter in an organic light emitting device at room temperature, and the first compound has at least one aromatic ring and at least one substituent R, where each of the at least one substituent R is directly bonded to one of the at least one aromatic rings. Each of the at least one substituent R has the formula of

where :

  • (a) G1 is selected from the group consisting of NR1, SiR1R2, GeR1R2, alkyl, cycloalkyl, and combinations thereof; and G2 is a non-aromatic polycyclic group, which can be further substituted by one or more R3;
  • (b) G1 is a direct bond; and G2 is a non-aromatic spiro polycyclic group, which can be further substituted by one or more R3; or
  • (c) G1 is selected from the group consisting of: direct bond, NR1, SiR1R2, GeR1R2, alkyl, cycloalkyl, and combinations thereof; G2 is a non-aromatic polycyclic group, which can be further substituted by one or more R3; and R is directly bonded to an aromatic ring selected from the group consisting of phenyl, pyridine, and triazine, which can be further fused to other rings;
  • R1, R2, and R3 are independently selected from the group consisting of hydrogen, deuterium, halide, alkyl, cycloalkyl, heteroalkyl, arylalkyl, alkoxy, aryloxy, amino, silyl, alkenyl, cycloalkenyl, heteroalkenyl, alkynyl, aryl, heteroaryl, acyl, carbonyl, carboxylic acids, ester, nitrile, isonitrile, sulfanyl, sulfinyl, sulfonyl, phosphino, and combinations thereof; and
  • each G1 and G2 can be independently, partially or fully deuterated.

According to another embodiment, an organic light emitting diode/device (OLED) is also provided. The OLED can include an anode, a cathode, and an organic layer, disposed between the anode and the cathode. The organic layer can include the first compound as described herein. According to yet another embodiment, the organic light emitting device is incorporated into one or more device selected from a consumer product, an electronic component module, and/or a lighting panel.

According to yet another embodiment, a formulation containing the first compound as described herein is provided.

BRIEF DESCRIPTION OF THE DRAWINGS

FIG. 1 shows an organic light emitting device.

FIG. 2 shows an inverted organic light emitting device that does not have a separate electron transport layer.

DETAILED DESCRIPTION

Generally, an OLED comprises at least one organic layer disposed between and electrically connected to an anode and a cathode. When a current is applied, the anode injects holes and the cathode injects electrons into the organic layer(s). The injected holes and electrons each migrate toward the oppositely charged electrode. When an electron and hole localize on the same molecule, an “exciton,” which is a localized electron-hole pair having an excited energy state, is formed. Light is emitted when the exciton relaxes via a photoemissive mechanism. In some cases, the exciton may be localized on an excimer or an exciplex. Non-radiative mechanisms, such as thermal relaxation, may also occur, but are generally considered undesirable.

The initial OLEDs used emissive molecules that emitted light from their singlet states (“fluorescence”) as disclosed, for example, in U.S. Pat. No. 4,769,292, which is incorporated by reference in its entirety. Fluorescent emission generally occurs in a time frame of less than 10 nanoseconds.

More recently, OLEDs having emissive materials that emit light from triplet states (“phosphorescence”) have been demonstrated. Baldo et al., “Highly Efficient Phosphorescent Emission from Organic Electroluminescent Devices,” Nature, vol. 395, 151-154, 1998; (“Baldo-I”) and Baldo et al., “Very high-efficiency green organic light-emitting devices based on electrophosphorescence,” Appl. Phys. Lett., vol. 75, No. 3, 4-6 (1999) (“Baldo-II”), are incorporated by reference in their entireties. Phosphorescence is described in more detail in U.S. Pat. No. 7,279,704 at cols. 5-6, which are incorporated by reference.

FIG. 1 shows an organic light emitting device 100. The figures are not necessarily drawn to scale. Device 100 may include a substrate 110, an anode 115, a hole injection layer 120, a hole transport layer 125, an electron blocking layer 130, an emissive layer 135, a hole blocking layer 140, an electron transport layer 145, an electron injection layer 150, a protective layer 155, a cathode 160, and a barrier layer 170. Cathode 160 is a compound cathode having a first conductive layer 162 and a second conductive layer 164. Device 100 may be fabricated by depositing the layers described, in order. The properties and functions of these various layers, as well as example materials, are described in more detail in US 7,279,704 at cols. 6-10, which are incorporated by reference.

More examples for each of these layers are available. For example, a flexible and transparent substrate-anode combination is disclosed in U.S. Pat. No. 5,844,363, which is incorporated by reference in its entirety. An example of a p-doped hole transport layer is m-MTDATA doped with F4-TCNQ at a molar ratio of 50:1, as disclosed in U.S. Pat. Application Publication No. 2003/0230980, which is incorporated by reference in its entirety. Examples of emissive and host materials are disclosed in U.S. Pat. No. 6,303,238 to Thompson et al., which is incorporated by reference in its entirety. An example of an n-doped electron transport layer is BPhen doped with Li at a molar ratio of 1:1, as disclosed in U.S. Pat. Application Publication No. 2003/0230980, which is incorporated by reference in its entirety. U.S. Pat. Nos. 5,703,436 and 5,707,745, which are incorporated by reference in their entireties, disclose examples of cathodes including compound cathodes having a thin layer of metal such as Mg:Ag with an overlying transparent, electrically-conductive, sputter-deposited ITO layer. The theory and use of blocking layers is described in more detail in U.S. Pat. No. 6,097,147 and U.S. Pat. Application Publication No. 2003/0230980, which are incorporated by reference in their entireties. Examples of injection layers are provided in U.S. Pat. Application Publication No. 2004/0174116, which is incorporated by reference in its entirety. A description of protective layers may be found in U.S. Pat. Application Publication No. 2004/0174116, which is incorporated by reference in its entirety.

FIG. 2 shows an inverted OLED 200. The device includes a substrate 210, a cathode 215, an emissive layer 220, a hole transport layer 225, and an anode 230. Device 200 may be fabricated by depositing the layers described, in order. Because the most common OLED configuration has a cathode disposed over the anode, and device 200 has cathode 215 disposed under anode 230, device 200 may be referred to as an “inverted” OLED. Materials similar to those described with respect to device 100 may be used in the corresponding layers of device 200. FIG. 2 provides one example of how some layers may be omitted from the structure of device 100.

The simple layered structure illustrated in FIGS. 1 and 2 is provided by way of nonlimiting example, and it is understood that embodiments of the invention may be used in connection with a wide variety of other structures. The specific materials and structures described are exemplary in nature, and other materials and structures may be used. Functional OLEDs may be achieved by combining the various layers described in different ways, or layers may be omitted entirely, based on design, performance, and cost factors. Other layers not specifically described may also be included. Materials other than those specifically described may be used. Although many of the examples provided herein describe various layers as comprising a single material, it is understood that combinations of materials, such as a mixture of host and dopant, or more generally a mixture, may be used. Also, the layers may have various sublayers. The names given to the various layers herein are not intended to be strictly limiting. For example, in device 200, hole transport layer 225 transports holes and injects holes into emissive layer 220, and may be described as a hole transport layer or a hole injection layer. In one embodiment, an OLED may be described as having an “organic layer” disposed between a cathode and an anode. This organic layer may comprise a single layer, or may further comprise multiple layers of different organic materials as described, for example, with respect to FIGS. 1 and 2.

Structures and materials not specifically described may also be used, such as OLEDs comprised of polymeric materials (PLEDs) such as disclosed in U.S. Pat. No. 5,247,190 to Friend et al., which is incorporated by reference in its entirety. By way of further example, OLEDs having a single organic layer may be used. OLEDs may be stacked, for example as described in U.S. Pat. No. 5,707,745 to Forrest et al, which is incorporated by reference in its entirety. The OLED structure may deviate from the simple layered structure illustrated in FIGS. 1 and 2. For example, the substrate may include an angled reflective surface to improve out-coupling, such as a mesa structure as described in U.S. Pat. No. 6,091,195 to Forrest et al., and/or a pit structure as described in U.S. Pat. No. 5,834,893 to Bulovic et al., which are incorporated by reference in their entireties.

Unless otherwise specified, any of the layers of the various embodiments may be deposited by any suitable method. For the organic layers, preferred methods include thermal evaporation, ink-jet, such as described in U.S. Pat. Nos. 6,013,982 and 6,087,196, which are incorporated by reference in their entireties, organic vapor phase deposition (OVPD), such as described in U.S. Pat. No. 6,337,102 to Forrest et al., which is incorporated by reference in its entirety, and deposition by organic vapor jet printing (OVJP), such as described in U.S. Pat. No. 7,431,968, which is incorporated by reference in its entirety. Other suitable deposition methods include spin coating and other solution based processes. Solution based processes are preferably carried out in nitrogen or an inert atmosphere. For the other layers, preferred methods include thermal evaporation. Preferred patterning methods include deposition through a mask, cold welding such as described in U.S. Pat. Nos. 6,294,398 and 6,468,819, which are incorporated by reference in their entireties, and patterning associated with some of the deposition methods such as ink-jet and OVJD. Other methods may also be used. The materials to be deposited may be modified to make them compatible with a particular deposition method. For example, substituents such as alkyl and aryl groups, branched or unbranched, and preferably containing at least 3 carbons, may be used in small molecules to enhance their ability to undergo solution processing. Substituents having 20 carbons or more may be used, and 3-20 carbons is a preferred range. Materials with asymmetric structures may have better solution processibility than those having symmetric structures, because asymmetric materials may have a lower tendency to recrystallize. Dendrimer substituents may be used to enhance the ability of small molecules to undergo solution processing.

Devices fabricated in accordance with embodiments of the present invention may further optionally comprise a barrier layer. One purpose of the barrier layer is to protect the electrodes and organic layers from damaging exposure to harmful species in the environment including moisture, vapor and/or gases, etc. The barrier layer may be deposited over, under or next to a substrate, an electrode, or over any other parts of a device including an edge. The barrier layer may comprise a single layer, or multiple layers. The barrier layer may be formed by various known chemical vapor deposition techniques and may include compositions having a single phase as well as compositions having multiple phases. Any suitable material or combination of materials may be used for the barrier layer. The barrier layer may incorporate an inorganic or an organic compound or both. The preferred barrier layer comprises a mixture of a polymeric material and a non-polymeric material as described in U.S. Pat. No. 7,968,146, PCT Pat. Application Nos. PCT/US2007/023098 and PCT/US2009/042829, which are herein incorporated by reference in their entireties. To be considered a “mixture”, the aforesaid polymeric and non-polymeric materials comprising the barrier layer should be deposited under the same reaction conditions and/or at the same time. The weight ratio of polymeric to non-polymeric material may be in the range of 95:5 to 5:95. The polymeric material and the non-polymeric material may be created from the same precursor material. In one example, the mixture of a polymeric material and a non-polymeric material consists essentially of polymeric silicon and inorganic silicon.

Devices fabricated in accordance with embodiments of the invention can be incorporated into a wide variety of electronic component modules (or units) that can be incorporated into a variety of electronic products or intermediate components. Examples of such electronic products or intermediate components include display screens, lighting devices such as discrete light source devices or lighting panels, etc. that can be utilized by the end-user product manufacturers. Such electronic component modules can optionally include the driving electronics and/or power source(s). Devices fabricated in accordance with embodiments of the invention can be incorporated into a wide variety of consumer products that have one or more of the electronic component modules (or units) incorporated therein. Such consumer products would include any kind of products that include one or more light source(s) and/or one or more of some type of visual displays. Some examples of such consumer products include flat panel displays, computer monitors, medical monitors, televisions, billboards, lights for interior or exterior illumination and/or signaling, heads-up displays, fully or partially transparent displays, flexible displays, laser printers, telephones, cell phones, tablets, phablets, personal digital assistants (PDAs), wearable device, laptop computers, digital cameras, camcorders, viewfinders, micro-displays, 3-D displays, vehicles, a large area wall, theater or stadium screen, or a sign. Various control mechanisms may be used to control devices fabricated in accordance with the present invention, including passive matrix and active matrix. Many of the devices are intended for use in a temperature range comfortable to humans, such as 18° C. to 30° C., and more preferably at room temperature (20-25° C.), but could be used outside this temperature range, for example, from -40° C. to + 80° C.

The materials and structures described herein may have applications in devices other than OLEDs. For example, other optoelectronic devices such as organic solar cells and organic photodetectors may employ the materials and structures. More generally, organic devices, such as organic transistors, may employ the materials and structures.

In the field of organic chemistry, a polycyclic compound is an organic chemical featuring several closed rings of atoms, primarily carbon. These ring substructures comprises cycloalkanes, aromatics, and other ring types. They come in sizes of three atoms and upward, and in combinations of linkages that include tethering (such as in biaryls), fusing (edge-to-edge, such as in anthracene and steroids), links via a single atom (such as in spiro compounds), and bridged cyclics such as adamantane. Though “poly” literally means “many”, in this context polycyclic includes smaller rings such as bicyclic, tricyclic, and tetracyclic.

The term “halo,” “halogen,” or “halide” as used herein includes fluorine, chlorine, bromine, and iodine.

The term “alkyl” as used herein contemplates both straight and branched chain alkyl radicals. Preferred alkyl groups are those containing from one to fifteen carbon atoms and includes methyl, ethyl, propyl, 1-methylethyl, butyl, 1-methylpropyl, 2-methylpropyl, pentyl, 1-methylbutyl, 2-methylbutyl, 3-methylbutyl, 1,1-dimethylpropyl, 1,2-dimethylpropyl, 2,2-dimethylpropyl,and the like. Additionally, the alkyl group may be optionally substituted.

The term “cycloalkyl” as used herein contemplates cyclic alkyl radicals. Preferred cycloalkyl groups are those containing 3 to 10 ring carbon atoms and includes cyclopropyl, cyclopentyl, cyclohexyl, adamantyl, and the like. Additionally, the cycloalkyl group may be optionally substituted.

The term “alkenyl” as used herein contemplates both straight and branched chain alkene radicals. Preferred alkenyl groups are those containing two to fifteen carbon atoms. Additionally, the alkenyl group may be optionally substituted.

The term “alkynyl” as used herein contemplates both straight and branched chain alkyne radicals. Preferred alkynyl groups are those containing two to fifteen carbon atoms. Additionally, the alkynyl group may be optionally substituted.

The terms “aralkyl” or “arylalkyl” as used herein are used interchangeably and contemplate an alkyl group that has as a substituent an aromatic group. Additionally, the aralkyl group may be optionally substituted.

The term “heterocyclic group” as used herein contemplates aromatic and non-aromatic cyclic radicals. Hetero-aromatic cyclic radicals also means heteroaryl. Preferred hetero-non-aromatic cyclic groups are those containing 3 to 7 ring atoms which includes at least one hetero atom, and includes cyclic amines such as morpholino, piperdino, pyrrolidino, and the like, and cyclic ethers, such as tetrahydrofuran, tetrahydropyran, and the like. Additionally, the heterocyclic group may be optionally substituted.

The term “aryl” or “aromatic group” as used herein contemplates single-ring groups and polycyclic ring systems. The polycyclic rings may have two or more rings in which two carbons are common to two adjoining rings (the rings are “fused”) wherein at least one of the rings is aromatic, e.g., the other rings can be cycloalkyls, cycloalkenyls, aryl, heterocycles, and/or heteroaryls. Preferred aryl groups are those containing six to thirty carbon atoms, preferably six to twenty carbon atoms, more preferably six to twelve carbon atoms. Especially preferred is an aryl group having six carbons, ten carbons or twelve carbons. Suitable aryl groups include phenyl, biphenyl, triphenyl, triphenylene, tetraphenylene, naphthalene, anthracene, phenalene, phenanthrene, fluorene, pyrene, chrysene, perylene, and azulene, preferably phenyl, biphenyl, triphenyl, triphenylene, fluorene, and naphthalene. Additionally, the aryl group may be optionally substituted.

The term “heteroaryl” as used herein contemplates single-ring hetero-aromatic groups that may include from one to five heteroatoms. The term heteroaryl also includes polycyclic hetero-aromatic systems having two or more rings in which two atoms are common to two adjoining rings (the rings are “fused”) wherein at least one of the rings is a heteroaryl, e.g., the other rings can be cycloalkyls, cycloalkenyls, aryl, heterocycles, and/or heteroaryls. Preferred heteroaryl groups are those containing three to thirty carbon atoms, preferably three to twenty carbon atoms, more preferably three to twelve carbon atoms. Suitable heteroaryl groups include dibenzothiophene, dibenzofuran, dibenzoselenophene, furan, thiophene, benzofuran, benzothiophene, benzoselenophene, carbazole, indolocarbazole, pyridylindole, pyrrolodipyridine, pyrazole, imidazole, triazole, oxazole, thiazole, oxadiazole, oxatriazole, dioxazole, thiadiazole, pyridine, pyridazine, pyrimidine, pyrazine, triazine, oxazine, oxathiazine, oxadiazine, indole, benzimidazole, indazole, indoxazine, benzoxazole, benzisoxazole, benzothiazole, quinoline, isoquinoline, cinnoline, quinazoline, quinoxaline, naphthyridine, phthalazine, pteridine, xanthene, acridine, phenazine, phenothiazine, phenoxazine, benzofuropyridine, furodipyridine, benzothienopyridine, thienodipyridine, benzoselenophenopyridine, and selenophenodipyridine, preferably dibenzothiophene, dibenzofuran, dibenzoselenophene, carbazole, indolocarbazole, imidazole, pyridine, triazine, benzimidazole, 1,2-azaborine, 1,3-azaborine, 1,4-azaborine, borazine, and aza-analogs thereof. Additionally, the heteroaryl group may be optionally substituted.

The alkyl, cycloalkyl, alkenyl, alkynyl, aralkyl, heterocyclic group, aryl, and heteroaryl may be unsubstituted or may be substituted with one or more substituents selected from the group consisting of deuterium, halogen, alkyl, cycloalkyl, heteroalkyl, arylalkyl, alkoxy, aryloxy, amino, cyclic amino, silyl, alkenyl, cycloalkenyl, heteroalkenyl, alkynyl, aryl, heteroaryl, acyl, carbonyl, carboxylic acid, ether, ester, nitrile, isonitrile, sulfanyl, sulfinyl, sulfonyl, phosphino, and combinations thereof.

As used herein, “substituted” indicates that a substituent other than H is bonded to the relevant position, such as carbon. Thus, for example, where R1 is mono-substituted, then one R1 must be other than H. Similarly, where R1 is di-substituted, then two of R1 must be other than H. Similarly, where R1 is unsubstituted, R1 is hydrogen for all available positions.

The “aza” designation in the fragments described herein, i.e. aza-dibenzofuran, aza-dibenzothiophene, etc. means that one or more of the C-H groups in the respective fragment can be replaced by a nitrogen atom, for example, and without any limitation, azatriphenylene encompasses both dibenzo[f,h]quinoxaline and dibenzo[f,h]quinoline. One of ordinary skill in the art can readily envision other nitrogen analogs of the aza-derivatives described above, and all such analogs are intended to be encompassed by the terms as set forth herein.

It is to be understood that when a molecular fragment is described as being a substituent or otherwise attached to another moiety, its name may be written as if it were a fragment (e.g. phenyl, phenylene, naphthyl, dibenzofuryl) or as if it were the whole molecule (e.g. benzene, naphthalene, dibenzofuran). As used herein, these different ways of designating a substituent or attached fragment are considered to be equivalent.

According to one embodiment, a composition comprising a first compound is described. In the composition, the first compound is capable of functioning as a phosphorescent emitter in an organic light emitting device at room temperature, and the first compound has at least one aromatic ring and at least one substituent R, where each of the at least one substituent R is directly bonded to one of the at least one aromatic rings. Each of the at least one substituent R has the formula of

where :

  • (a) G1 is selected from the group consisting of NR1, SiR1R2, GeR1R2, alkyl, cycloalkyl, and combinations thereof; and G2 is a non-aromatic polycyclic group, which can be further substituted by one or more R3;
  • (b) G1 is a direct bond; and G2 is a non-aromatic spiro polycyclic group, which can be further substituted by one or more R3; or
  • (c) G1 is selected from the group consisting of: direct bond, NR1, SiR1R2, GeR1R2, alkyl, cycloalkyl, and combinations thereof; G2 is a non-aromatic polycyclic group, which can be further substituted by one or more R3; and R is directly bonded to an aromatic ring selected from the group consisting of phenyl, pyridine, and triazine, which can be further fused to other rings;
  • wherein R1, R2, and R3 are independently selected from the group consisting of hydrogen, deuterium, halide, alkyl, cycloalkyl, heteroalkyl, arylalkyl, alkoxy, aryloxy, amino, silyl, alkenyl, cycloalkenyl, heteroalkenyl, alkynyl, aryl, heteroaryl, acyl, carbonyl, carboxylic acids, ester, nitrile, isonitrile, sulfanyl, sulfinyl, sulfonyl, phosphino, and combinations thereof; and
  • each G1 and G2 can be independently, partially or fully deuterated.

In some embodiments, G1 is SiR1R2. In some embodiments, G1 is NR1. In some embodiments, G1 is alkyl. In some such embodiments, G1 is selected from the gourp consisiting of divalent methyl, ethyl, propyl, and butyl. In some embodiments, G1 is fully or partially deuterated.

In some embodiments, G2 is polycyclic alkyl. In some embodiments, G2 is carborane. In some embodiments, G2 contains at least one heteroatom. In some embodiments, G2 includes at least one heterocyclic group.

In some embodiments, the first compound is capable of emitting light from a triplet excited state to a ground singlet state at room temperature.

In some embodiments, the first compound is a metal coordination complex having a metal-carbon bond. In some such embodiments, the metal is selected from the group consisting of Ir, Rh, Re, Ru, Os, Pt, Au, and Cu. In some such embodiments, the metal is Ir, while the metal is Pt is other embodiments.

In some embodiments, the first compound has the formula of M(L1)x(L2)y(L3)z, where:

  • L1, L2 and L3 can be the same or different;
  • x is 1, 2, or 3;
  • y is 0, 1, or 2;
  • z is 0, 1, or 2;
  • x+y+z is the oxidation state of the metal M;
  • L1, L2 and L3 are each independently selected from the group consisting of:
  • , and
  • each X1 to X17 are independently selected from the group consisting of carbon and nitrogen;
  • X is selected from the group consisting of BR′, NR′, PR′, O, S, Se, C═O, S═O, SO2, CR′R″, SiR′R″, and GeR′R″;
  • each R′ and R″ is independently, optionally fused or joined to form a ring;
  • each Ra, Rb, Rc, and Rd independently represents from mono substitution to the maximum possible number of substitutions, or no substitution;
  • each R′, R″, Ra, Rb, Rc, and Rd is independently selected from the group consisting of hydrogen, deuterium, halide, alkyl, cycloalkyl, heteroalkyl, arylalkyl, alkoxy, aryloxy, amino, silyl, alkenyl, cycloalkenyl, heteroalkenyl, alkynyl, aryl, heteroaryl, acyl, carbonyl, carboxylic acids, ester, nitrile, isonitrile, sulfanyl, sulfinyl, sulfonyl, phosphino, and combinations thereof;
  • any two adjacent substitutents of Ra, Rb, Rc, and Rd are optionally fused or joined to form a ring or form a multidentate ligand; and
  • at least one of the Ra, Rb, Rc, and Rd includes the at least one substituent R.

In some embodiments where the first compound has the structure M(L1)x(L2)y(L3)z, the first compound has the formula of Ir(L1)2(L2). In some such embodiments, L1 has the formula selected from the group consisting of:

and

and L2 has the formula

In some such embodiments, L2 has the formula:

where:

  • Re, Rf, Rh, and Ri are independently selected from group consisting of alkyl, cycloalkyl, aryl, and heteroaryl;
  • at least one of Re, Rf, Rh, and Ri has at least two carbon atoms; and
  • Rg is selected from group consisting of hydrogen, deuterium, halogen, alkyl, cycloalkyl, heteroalkyl, arylalkyl, alkoxy, aryloxy, amino, silyl, alkenyl, cycloalkenyl, heteroalkenyl, alkynyl, aryl, heteroaryl, acyl, carbonyl, carboxylic acid, ester, nitrile, isonitrile, sulfanyl, sulfinyl, sulfonyl, phosphino, and combinations thereof.

In some embodiments where the first compound has the formula of Ir(L1)2(L2), ligands L1 and L2 are different and each independently selected from the group consisting of:

, and

In some embodiments where the first compound has the formula of Ir(L1)2(L2), ligands L1 and L2 are each independently selected from the group consisting of:

, and

In some embodiments where the first compound has the structure M(L1)x(L2)y(L3)z, the first compound has the formula of Pt(L1)2 or Pt(L1)(L2). In some embodiments where the first compound has the formula of Pt(L1)2 or Pt(L1)(L2), one L1 is connected to the other L1 or L2 to form a tetradentate ligand.

In some embodiments where the first compound has the structure M(L1)x(L2)y(L3)z, at least one of Ra, Rb, Rc, and Rd includes an alkyl or cycloalkyl group that is partially or fully deuterated.

In some embodiments, G2 is selected from the group consisting of:

In some embodiments, each of the at least one substituent R is independently selected from the group consisting of:

, and

In some embodiments where the first compound has the structure M(L1)x(L2)y(L3)z,, at least one of L1, L2, and L3 is selected from the group consisting of:

, and

In some embodiments where the first compound has the formula of Ir(L1)2(L2), ligands L1 and L2 are different and each independently selected from the group consisting of:

and

In some embodiments where the first compound has the formula of M(L1)x(L2)y(L3)z, ligand L1 is LA having the following structure:

selected from the group consisting of LA1 to LA2480 as listed below:

Ligand RA1 RA2 RA3 RA4 RA5 RA6 Ligand RA1 RA2 RA3 RA4 RA5 RA6 LA1 RG1 H H H H H LA1241 CD3 H RG58 H H H LA2 RG2 H H H H H LA1242 CD3 H RG59 H H H LA3 RG3 H H H H H LA1243 CD3 H RG60 H H H LA4 RG4 H H H H H LA1244 CD3 H RG61 H H H

Ligand RA1 RA2 RA3 RA4 RA5 RA6 Ligand RA1 RA2 RA3 RA4 RA5 RA6 LA5 RG5 H H H H H LA1245 CD3 H RG62 H H H LA6 RG6 H H H H H LA1246 CD3 H RG63 H H H LA7 RG7 H H H H H LA1247 CD3 H RG64 H H H LA8 RG8 H H H H H LA1248 CD3 H RG65 H H H LA9 RG9 H H H H H LA1249 CD3 H RG66 H H H LA10 RG10 H H H H H LA1250 CD3 H RG67 H H H LA11 RG11 H H H H H LA1251 CD3 H RG68 H H H LA12 RG12 H H H H H LA1252 CD3 H RG69 H H H LA13 RG13 H H H H H LA1253 CD3 H RG70 H H H LA14 RG14 H H H H H LA1254 CD3 H RG71 H H H LA15 RG15 H H H H H LA1255 CD3 H RG72 H H H LA16 RG16 H H H H H LA1256 CD3 H RG73 H H H LA17 RG17 H H H H H LA1257 CD3 H RG74 H H H LA18 RG18 H H H H H LA1258 CD3 H RG75 H H H LA19 RG19 H H H H H LA1259 CD3 H RG76 H H H LA20 RG20 H H H H H LA1260 CD3 H RG77 H H H LA21 RG21 H H H H H LA1261 CD3 H RG78 H H H LA22 RG22 H H H H H LA1262 CD3 H RG79 H H H LA23 RG23 H H H H H LA1263 CD3 H RG80 H H H LA24 RG24 H H H H H LA1264 CD3 H RG81 H H H LA25 RG25 H H H H H LA1265 CD3 H RG82 H H H LA26 RG26 H H H H H LA1266 CD3 H RG83 H H H LA27 RG27 H H H H H LA1267 CD3 H RG84 H H H LA28 RG28 H H H H H LA1268 CD3 H RG85 H H H

Ligand RA1 RA2 RA3 RA4 RA5 RA6 Ligand RA1 RA2 RA3 RA4 RA5 RA6 LA29 RG29 H H H H H LA1269 CD3 H RG86 H H H LA30 RG30 H H H H H LA1270 CD3 H RG87 H H H LA31 RG31 H H H H H LA1271 CD3 H RG88 H H H LA32 RG32 H H H H H LA1272 CD3 H RG89 H H H LA33 RG33 H H H H H LA1273 CD3 H RG90 H H H LA34 RG34 H H H H H LA1274 CD3 H RG91 H H H LA35 RG35 H H H H H LA1275 CD3 H RG92 H H H LA36 RG36 H H H H H LA1276 CD3 H RG93 H H H LA37 RG37 H H H H H LA1277 CD3 H RG94 H H H LA38 RG38 H H H H H LA1278 CD3 H RG95 H H H LA39 RG39 H H H H H LA1279 CD3 H RG96 H H H LA40 RG40 H H H H H LA1280 CD3 H RG97 H H H LA41 RG41 H H H H H LA1281 CD3 H RG98 H H H LA42 RG42 H H H H H LA1282 CD3 H RG99 H H H LA43 RG43 H H H H H LA1283 CD3 H RG100 H H H LA44 RG44 H H H H H LA1284 CD3 H RG101 H H H LA45 RG45 H H H H H LA1285 CD3 H RG102 H H H LA46 RG46 H H H H H LA1286 CD3 H RG103 H H H LA47 RG47 H H H H H LA1287 CD3 H RG104 H H H LA48 RG48 H H H H H LA1288 CD3 H RG105 H H H LA49 RG49 H H H H H LA1289 CD3 H RG106 H H H LA50 RG50 H H H H H LA1290 CD3 H RG107 H H H LA51 RG51 H H H H H LA1291 CD3 H RG108 H H H LA52 RG52 H H H H H LA1292 CD3 H RG109 H H H

Ligand RA1 RA2 RA3 RA4 RA5 RA6 Ligand RA1 RA2 RA3 RA4 RA5 RA6 LA53 RG53 H H H H H LA1293 CD3 H RG110 H H H LA54 RG54 H H H H H LA1294 CD3 H RG111 H H H LA55 RG55 H H H H H LA1295 CD3 H RG112 H H H LA56 RG56 H H H H H LA1296 CD3 H RG113 H H H LA57 RG57 H H H H H LA1297 CD3 H RG114 H H H LA58 RG58 H H H H H LA1298 CD3 H RG115 H H H LA59 RG59 H H H H H LA1299 CD3 H RG116 H H H LA60 RG60 H H H H H LA1300 CD3 H RG117 H H H LA61 RG61 H H H H H LA1301 CD3 H RG118 H H H LA62 RG62 H H H H H LA1302 CD3 H RG119 H H H LA63 RG63 H H H H H LA1303 CD3 H RG120 H H H LA64 RG64 H H H H H LA1304 CD3 H RG121 H H H LA65 RG65 H H H H H LA1305 CD3 H RG122 H H H LA66 RG66 H H H H H LA1306 CD3 H RG123 H H H LA67 RG67 H H H H H LA1307 CD3 H RG124 H H H LA68 RG68 H H H H H LA1308 CD3 H RG125 H H H LA69 RG69 H H H H H LA1309 CD3 H RG126 H H H LA70 RG70 H H H H H LA1310 CD3 H RG127 H H H LA71 RG71 H H H H H LA1311 CD3 H RG128 H H H LA72 RG72 H H H H H LA1312 CD3 H RG129 H H H LA73 RG73 H H H H H LA1313 CD3 H RG130 H H H LA74 RG74 H H H H H LA1314 CD3 H RG131 H H H LA75 RG75 H H H H H LA1315 CD3 H RG132 H H H LA76 RG76 H H H H H LA1316 CD3 H RG133 H H H

Ligand RA1 RA2 RA3 RA4 RA5 RA6 Ligand RA1 RA2 RA3 RA4 RA5 RA6 LA77 RG77 H H H H H LA1317 CD3 H RG134 H H H LA78 RG78 H H H H H LA1318 CD3 H RG135 H H H LA79 RG79 H H H H H LA1319 CD3 H RG136 H H H LA80 RG80 H H H H H LA1320 CD3 H RG137 H H H LA81 RG81 H H H H H LA1321 CD3 H RG138 H H H LA82 RG82 H H H H H LA1322 CD3 H RG139 H H H LA83 RG83 H H H H H LA1323 CD3 H RG140 H H H LA84 RG84 H H H H H LA1324 CD3 H RG141 H H H LA85 RG85 H H H H H LA13 25 CD3 H RG142 H H H LA86 RG86 H H H H H LA1326 CD3 H RG143 H H H LA87 RG87 H H H H H LA1327 CD3 H RG144 H H H LA88 RG88 H H H H H LA1328 CD3 H RG145 H H H LA89 RG89 H H H H H LA1329 CD3 H RG146 H H H LA90 RG90 H H H H H LA1330 CD3 H RG147 H H H LA91 RG91 H H H H H LA1331 CD3 H RG148 H H H LA92 RG92 H H H H H LA1332 CD3 H RG149 H H H LA93 RG93 H H H H H LA1333 CD3 H RG150 H H H LA94 RG94 H H H H H LA1334 CD3 H RG151 H H H LA95 RG95 H H H H H LA1335 CD3 H RG152 H H H LA96 RG96 H H H H H LA1336 CD3 H RG153 H H H LA97 RG97 H H H H H LA1337 CD3 H RG154 H H H LA98 RG98 H H H H H LA1338 CD3 H RG155 H H H LA99 RG99 H H H H H LA1339 CD3 H RG156 H H H LA100 RG100 H H H H H LA1340 CD3 H RG157 H H H

Ligand RA1 RA2 RA3 RA4 RA5 RA6 Ligand RA1 RA2 RA3 RA4 RA5 RA6 LA101 RG101 H H H H H LA1341 CD3 H RG158 H H H LA102 RG102 H H H H H LA1342 CD3 H RG159 H H H LA103 RG103 H H H H H LA1343 CD3 H RG160 H H H LA104 RG104 H H H H H LA1344 CD3 H RG161 H H H LA105 RG105 H H H H H LA1345 CD3 H RG162 H H H LA106 RG106 H H H H H LA1346 CD3 H RG163 H H H LA107 RG107 H H H H H LA1347 CD3 H RG164 H H H LA108 RG108 H H H H H LA1348 CD3 H RG165 H H H LA109 RG109 H H H H H LA1349 CD3 H RG166 H H H LA110 RG110 H H H H H LA1350 CD3 H RG167 H H H LA111 RG111 H H H H H LA1351 CD3 H RG168 H H H LA112 RG112 H H H H H LA1352 CD3 H RG169 H H H LA113 RG113 H H H H H LA1353 H CD3 RG1 H H H LA114 RG114 H H H H H LA1354 H CD3 RG2 H H H LA115 RG115 H H H H H LA1355 H CD3 RG3 H H H LA116 RG116 H H H H H LA1356 H CD3 RG4 H H H LA117 RG117 H H H H H LA1357 H CD3 RG5 H H H LA118 RG118 H H H H H LA1358 H CD3 RG6 H H H LA119 RG119 H H H H H LA1359 H CD3 RG7 H H H LA120 RG120 H H H H H LA1360 H CD3 RG8 H H H LA121 RG121 H H H H H LA1361 H CD3 RG9 H H H LA122 RG122 H H H H H LA1362 H CD3 RG10 H H H LA123 RG123 H H H H H LA1363 H CD3 RG11 H H H LA124 RG124 H H H H H LA1364 H CD3 RG12 H H H

Ligand RA1 RA2 RA3 RA4 RA5 RA6 Ligand RA1 RA2 RA3 RA4 RA5 RA6 LA125 RG125 H H H H H LA1365 H CD3 RG13 H H H LA126 RG126 H H H H H LA1366 H CD3 RG14 H H H LA127 RG127 H H H H H LA1367 H CD3 RG15 H H H LA128 RG128 H H H H H LA1368 H CD3 RG16 H H H LA129 RG129 H H H H H LA1369 H CD3 RG17 H H H LA130 RG130 H H H H H LA1370 H CD3 RG18 H H H LA131 RG131 H H H H H LA1371 H CD3 RG19 H H H LA132 RG132 H H H H H LA1372 H CD3 RG20 H H H LA133 RG133 H H H H H LA1373 H CD3 RG21 H H H LA134 RG134 H H H H H LA1374 H CD3 RG22 H H H LA135 RG135 H H H H H LA1375 H CD3 RG23 H H H LA136 RG136 H H H H H LA1376 H CD3 RG24 H H H LA137 RG137 H H H H H LA1377 H CD3 RG25 H H H LA138 RG138 H H H H H LA1378 H CD3 RG26 H H H LA139 RG139 H H H H H LA1379 H CD3 RG27 H H H LA140 RG140 H H H H H LA1380 H CD3 RG28 H H H LA141 RG141 H H H H H LA1381 H CD3 RG29 H H H LA142 RG142 H H H H H LA1382 H CD3 RG30 H H H LA143 RG143 H H H H H LA1383 H CD3 RG31 H H H LA144 RG144 H H H H H LA1384 H CD3 RG32 H H H LA145 RG145 H H H H H LA1385 H CD3 RG33 H H H LA146 RG146 H H H H H LA1386 H CD3 RG34 H H H LA147 RG147 H H H H H LA1387 H CD3 RG35 H H H LA148 RG148 H H H H H LA1388 H CD3 RG36 H H H

Ligand RA1 RA2 RA3 RA4 RA5 RA6 Ligand RA1 RA2 RA3 RA4 RA5 RA6 LA149 RG149 H H H H H LA1389 H CD3 RG37 H H H LA150 RG150 H H H H H LA1390 H CD3 RG38 H H H LA151 RG151 H H H H H LA1391 H CD3 RG39 H H H LA152 RG152 H H H H H LA1392 H CD3 RG40 H H H LA153 RG153 H H H H H LA1393 H CD3 RG41 H H H LA154 RG154 H H H H H LA1394 H CD3 RG42 H H H LA155 RG155 H H H H H LA1395 H CD3 RG43 H H H LA156 RG156 H H H H H LA1396 H CD3 RG44 H H H LA157 RG157 H H H H H LA1397 H CD3 RG45 H H H LA158 RG158 H H H H H LA1398 H CD3 RG46 H H H LA159 RG159 H H H H H LA1399 H CD3 RG47 H H H LA160 RG160 H H H H H LA1400 H CD3 RG48 H H H LA161 RG161 H H H H H LA1401 H CD3 RG49 H H H LA162 RG162 H H H H H LA1402 H CD3 RG50 H H H LA163 RG163 H H H H H LA1403 H CD3 RG51 H H H LA164 RG164 H H H H H LA1404 H CD3 RG52 H H H LA165 RG165 H H H H H LA1405 H CD3 RG53 H H H LA166 RG166 H H H H H LA1406 H CD3 RG54 H H H LA167 RG167 H H H H H LA1407 H CD3 RG55 H H H LA168 RG168 H H H H H LA1408 H CD3 RG56 H H H LA169 RG169 H H H H H LA1409 H CD3 RG57 H H H LA170 RG1 H CD3 H H H LA1410 H CD3 RG58 H H H LA171 RG2 H CD3 H H H LA1411 H CD3 RG59 H H H LA172 RG3 H CD3 H H H LA1412 H CD3 RG60 H H H

Ligand RA1 RA2 RA3 RA4 RA5 RA6 Ligand RA1 RA2 RA3 RA4 RA5 RA6 LA173 RG4 H CD3 H H H LA1413 H CD3 RG61 H H H LA174 RG5 H CD3 H H H LA1414 H CD3 RG62 H H H LA175 RG6 H CD3 H H H LA1415 H CD3 RG63 H H H LA176 RG7 H CD3 H H H LA1416 H CD3 RG64 H H H LA177 RG8 H CD3 H H H LA1417 H CD3 RG65 H H H LA178 RG9 H CD3 H H H LA1418 H CD3 RG66 H H H LA179 RG10 H CD3 H H H LA1419 H CD3 RG67 H H H LA180 RG11 H CD3 H H H LA1420 H CD3 RG68 H H H LA181 RG12 H CD3 H H H LA1421 H CD3 RG69 H H H LA182 RG13 H CD3 H H H LA1422 H CD3 RG70 H H H LA183 RG14 H CD3 H H H LA1423 H CD3 RG71 H H H LA184 RG15 H CD3 H H H LA1424 H CD3 RG72 H H H LA185 RG16 H CD3 H H H LA1425 H CD3 RG73 H H H LA186 RG17 H CD3 H H H LA1426 H CD3 RG74 H H H LA187 RG18 H CD3 H H H LA1427 H CD3 RG75 H H H LA188 RG19 H CD3 H H H LA1428 H CD3 RG76 H H H LA189 RG20 H CD3 H H H LA1429 H CD3 RG77 H H H LA190 RG21 H CD3 H H H LA1430 H CD3 RG78 H H H LA191 RG22 H CD3 H H H LA1431 H CD3 RG79 H H H LA192 RG23 H CD3 H H H LA1432 H CD3 RG80 H H H LA193 RG24 H CD3 H H H LA1433 H CD3 RG81 H H H LA194 RG25 H CD3 H H H LA1434 H CD3 RG82 H H H LA195 RG26 H CD3 H H H LA1435 H CD3 RG83 H H H LA196 RG27 H CD3 H H H LA1436 H CD3 RG84 H H H

Ligand RA1 RA2 RA3 RA4 RA5 RA6 Ligand RA1 RA2 RA3 RA4 RA5 RA6 LA197 RG28 H CD3 H H H LA1437 H CD3 RG85 H H H LA198 RG29 H CD3 H H H LA1438 H CD3 RG86 H H H LA199 RG30 H CD3 H H H LA1439 H CD3 RG87 H H H LA200 RG31 H CD3 H H H LA1440 H CD3 RG88 H H H LA201 RG32 H CD3 H H H LA1441 H CD3 RG89 H H H LA202 RG33 H CD3 H H H LA1442 H CD3 RG90 H H H LA203 RG34 H CD3 H H H LA1443 H CD3 RG91 H H H LA204 RG35 H CD3 H H H LA1444 H CD3 RG92 H H H LA205 RG36 H CD3 H H H LA1445 H CD3 RG93 H H H LA206 RG37 H CD3 H H H LA1446 H CD3 RG94 H H H LA207 RG38 H CD3 H H H LA1447 H CD3 RG95 H H H LA208 RG39 H CD3 H H H LA1448 H CD3 RG96 H H H LA209 RG40 H CD3 H H H LA1449 H CD3 RG97 H H H LA210 RG41 H CD3 H H H LA1450 H CD3 RG98 H H H LA211 RG42 H CD3 H H H LA1451 H CD3 RG99 H H H LA212 RG43 H CD3 H H H LA1452 H CD3 RG100 H H H LA213 RG44 H CD3 H H H LA1453 H CD3 RG101 H H H LA214 RG45 H CD3 H H H LA1454 H CD3 RG102 H H H LA215 RG46 H CD3 H H H LA1455 H CD3 RG103 H H H LA216 RG47 H CD3 H H H LA1456 H CD3 RG104 H H H LA217 RG48 H CD3 H H H LA1457 H CD3 RG105 H H H LA218 RG49 H CD3 H H H LA1458 H CD3 RG106 H H H LA219 RG50 H CD3 H H H LA1459 H CD3 RG107 H H H LA220 RG51 H CD3 H H H LA1460 H CD3 RG108 H H H

Ligand RA1 RA2 RA3 RA4 RA5 RA6 Ligand RA1 RA2 RA3 RA4 RA5 RA6 LA221 RG52 H CD3 H H H LA1461 H CD3 RG109 H H H LA222 RG53 H CD3 H H H LA1462 H CD3 RG110 H H H LA223 RG54 H CD3 H H H LA1463 H CD3 RG111 H H H LA224 RG55 H CD3 H H H LA1464 H CD3 RG112 H H H LA225 RG56 H CD3 H H H LA1465 H CD3 RG113 H H H LA226 RG57 H CD3 H H H LA1466 H CD3 RG114 H H H LA227 RG58 H CD3 H H H LA1467 H CD3 RG115 H H H LA228 RG59 H CD3 H H H LA1468 H CD3 RG116 H H H LA229 RG60 H CD3 H H H LA1469 H CD3 RG117 H H H LA230 RG61 H CD3 H H H LA1470 H CD3 RG118 H H H LA231 RG62 H CD3 H H H LA1471 H CD3 RG119 H H H LA232 RG63 H CD3 H H H LA1472 H CD3 RG120 H H H LA233 RG64 H CD3 H H H LA1473 H CD3 RG121 H H H LA234 RG65 H CD3 H H H LA1474 H CD3 RG122 H H H LA235 RG66 H CD3 H H H LA1475 H CD3 RG123 H H H LA236 RG67 H CD3 H H H LA1476 H CD3 RG124 H H H LA237 RG68 H CD3 H H H LA1477 H CD3 RG125 H H H LA238 RG69 H CD3 H H H LA1478 H CD3 RG126 H H H LA239 RG70 H CD3 H H H LA1479 H CD3 RG127 H H H LA240 RG71 H CD3 H H H LA1480 H CD3 RG128 H H H LA241 RG72 H CD3 H H H LA1481 H CD3 RG129 H H H LA242 RG73 H CD3 H H H LA1482 H CD3 RG130 H H H LA243 RG74 H CD3 H H H LA1483 H CD3 RG131 H H H LA244 RG75 H CD3 H H H LA1484 H CD3 RG132 H H H

Ligand RA1 RA2 RA3 RA4 RA5 RA6 Ligand RA1 RA2 RA3 RA4 RA5 RA6 LA245 RG76 H CD3 H H H LA1485 H CD3 RG133 H H H LA246 RG77 H CD3 H H H LA1486 H CD3 RG134 H H H LA247 RG78 H CD3 H H H LA1487 H CD3 RG135 H H H LA248 RG79 H CD3 H H H LA1488 H CD3 RG136 H H H LA249 RG80 H CD3 H H H LA1489 H CD3 RG137 H H H LA250 RG81 H CD3 H H H LA1490 H CD3 RG138 H H H LA251 RG82 H CD3 H H H LA1491 H CD3 RG139 H H H LA252 RG83 H CD3 H H H LA1492 H CD3 RG140 H H H LA253 RG84 H CD3 H H H LA1493 H CD3 RG141 H H H LA254 RG85 H CD3 H H H LA1494 H CD3 RG142 H H H LA255 RG86 H CD3 H H H LA1495 H CD3 RG143 H H H LA256 RG87 H CD3 H H H LA1496 H CD3 RG144 H H H LA257 RG88 H CD3 H H H LA1497 H CD3 RG145 H H H LA258 RG89 H CD3 H H H LA1498 H CD3 RG146 H H H LA259 RG90 H CD3 H H H LA1499 H CD3 RG147 H H H LA260 RG91 H CD3 H H H LA1500 H CD3 RG148 H H H LA261 RG92 H CD3 H H H LA1501 H CD3 RG149 H H H LA262 RG93 H CD3 H H H LA1502 H CD3 RG150 H H H LA263 RG94 H CD3 H H H LA1503 H CD3 RG151 H H H LA264 RG95 H CD3 H H H LA1504 H CD3 RG152 H H H LA265 RG96 H CD3 H H H LA1505 H CD3 RG153 H H H LA266 RG97 H CD3 H H H LA1506 H CD3 RG154 H H H LA267 RG98 H CD3 H H H LA1507 H CD3 RG155 H H H LA268 RG99 H CD3 H H H LA1508 H CD3 RG156 H H H

Ligand RA1 RA2 RA3 RA4 RA5 RA6 Ligand RA1 RA2 RA3 RA4 RA5 RA6 LA269 RG100 H CD3 H H H LA1509 H CD3 RG157 H H H LA270 RG101 H CD3 H H H LA1510 H CD3 RG158 H H H LA271 RG102 H CD3 H H H LA1511 H CD3 RG159 H H H LA272 RG103 H CD3 H H H LA1512 H CD3 RG160 H H H LA273 RG104 H CD3 H H H LA1513 H CD3 RG161 H H H LA274 RG105 H CD3 H H H LA1514 H CD3 RG162 H H H LA275 RG106 H CD3 H H H LA1515 H CD3 RG163 H H H LA276 RG107 H CD3 H H H LA1516 H CD3 RG164 H H H LA277 RG108 H CD3 H H H LA1517 H CD3 RG165 H H H LA278 RG109 H CD3 H H H LA1518 H CD3 RG166 H H H LA279 RG110 H CD3 H H H LA1519 H CD3 RG167 H H H LA280 RG111 H CD3 H H H LA1520 H CD3 RG168 H H H LA281 RG112 H CD3 H H H LA1521 H CD3 RG169 H H H LA282 RG113 H CD3 H H H LA1522 RG1 CD3 CD3 H H H LA283 RG114 H CD3 H H H LA1523 RG2 CD3 CD3 H H H LA284 RG115 H CD3 H H H LA1524 RG3 CD3 CD3 H H H LA285 RG116 H CD3 H H H LA1525 RG4 CD3 CD3 H H H LA286 RG117 H CD3 H H H LA1526 RG5 CD3 CD3 H H H LA287 RG118 H CD3 H H H LA1527 RG6 CD3 CD3 H H H LA288 RG119 H CD3 H H H LA1528 RG7 CD3 CD3 H H H LA289 RG120 H CD3 H H H LA1529 RG8 CD3 CD3 H H H LA290 RG121 H CD3 H H H LA1530 RG9 CD3 CD3 H H H LA291 RG122 H CD3 H H H LA1531 RG10 CD3 CD3 H H H LA292 RG123 H CD3 H H H LA1532 RG11 CD3 CD3 H H H

Ligand RA1 RA2 RA3 RA4 RA5 RA6 Ligand RA1 RA2 RA3 RA4 RA5 RA6 LA293 RG124 H CD3 H H H LA1533 RG12 CD3 CD3 H H H LA294 RG125 H CD3 H H H LA1534 RG13 CD3 CD3 H H H LA295 RG126 H CD3 H H H LA1535 RG14 CD3 CD3 H H H LA296 RG127 H CD3 H H H LA1536 RG15 CD3 CD3 H H H LA297 RG128 H CD3 H H H LA1537 RG16 CD3 CD3 H H H LA298 RG129 H CD3 H H H LA1538 RG17 CD3 CD3 H H H LA299 RG130 H CD3 H H H LA1539 RG18 CD3 CD3 H H H LA300 RG131 H CD3 H H H LA1540 RG19 CD3 CD3 H H H LA301 RG132 H CD3 H H H LA1541 CD3 RG1 H H H H LA302 RG133 H CD3 H H H LA1542 CD3 RG2 H H H H LA303 RG134 H CD3 H H H LA1543 CD3 RG3 H H H H LA304 RG135 H CD3 H H H LA1544 CD3 RG4 H H H H LA305 RG136 H CD3 H H H LA1545 CD3 RG5 H H H H LA306 RG137 H CD3 H H H LA1546 CD3 RG6 H H H H LA307 RG138 H CD3 H H H LA1547 CD3 RG7 H H H H LA308 RG139 H CD3 H H H LA1548 CD3 RG8 H H H H LA309 RG140 H CD3 H H H LA1549 CD3 RG9 H H H H LA310 RG141 H CD3 H H H LA1550 CD3 RG10 H H H H LA311 RG142 H CD3 H H H LA1551 CD3 RG11 H H H H LA312 RG143 H CD3 H H H LA1552 CD3 RG12 H H H H LA313 RG144 H CD3 H H H LA1553 CD3 RG13 H H H H LA314 RG145 H CD3 H H H LA1554 CD3 RG14 H H H H LA315 RG146 H CD3 H H H LA1555 CD3 RG15 H H H H LA316 RG147 H CD3 H H H LA1556 CD3 RG16 H H H H

Ligand RA1 RA2 RA3 RA4 RA5 RA6 Ligand RA1 RA2 RA3 RA4 RA5 RA6 LA317 RG148 H CD3 H H H LA1557 CD3 RG17 H H H H LA318 RG149 H CD3 H H H LA1558 CD3 RG18 H H H H LA319 RG150 H CD3 H H H LA1559 CD3 RG19 H H H H LA320 RG151 H CD3 H H H LA1560 CD3 CD3 RG1 H H CD3 LA321 RG152 H CD3 H H H LA1561 CD3 CD3 RG2 H H CD3 LA322 RG153 H CD3 H H H LA1562 CD3 CD3 RG3 H H CD3 LA323 RG154 H CD3 H H H LA1563 CD3 CD3 RG4 H H CD3 LA324 RG155 H CD3 H H H LA1564 CD3 CD3 RG5 H H CD3 LA325 RG156 H CD3 H H H LA1565 CD3 CD3 RG6 H H CD3 LA326 RG157 H CD3 H H H LA1566 CD3 CD3 RG7 H H CD3 LA327 RG158 H CD3 H H H LA1567 CD3 CD3 RG8 H H CD3 LA328 RG159 H CD3 H H H LA1568 CD3 CD3 RG9 H H CD3 LA329 RG160 H CD3 H H H LA1569 CD3 CD3 RG10 H H CD3 LA330 RG161 H CD3 H H H LA1570 CD3 CD3 RG11 H H CD3 LA331 RG162 H CD3 H H H LA1571 CD3 CD3 RG12 H H CD3 LA332 RG163 H CD3 H H H LA1572 CD3 CD3 RG13 H H CD3 LA333 RG164 H CD3 H H H LA1573 CD3 CD3 RG14 H H CD3 LA334 RG165 H CD3 H H H LA1574 CD3 CD3 RG15 H H CD3 LA335 RG166 H CD3 H H H LA1575 CD3 CD3 RG16 H H CD3 LA336 RG167 H CD3 H H H LA1576 CD3 CD3 RG17 H H CD3 LA337 RG168 H CD3 H H H LA1577 CD3 CD3 RG18 H H CD3 LA338 RG169 H CD3 H H H LA1578 CD3 CD3 RG19 H H CD3 LA339 RG1 CD3 CD3 H H CD3 LA1579 CD3 H RG1 H H CD3 LA340 RG2 CD3 CD3 H H CD3 LA1580 CD3 H RG2 H H CD3

Ligand RA1 RA2 RA3 RA4 RA5 RA6 Ligand RA1 RA2 RA3 RA4 RA5 RA6 LA341 RG3 CD3 CD3 H H CD3 LA1581 CD3 H RG3 H H CD3 LA342 RG4 CD3 CD3 H H CD3 LA1582 CD3 H RG4 H H CD3 LA343 RG5 CD3 CD3 H H CD3 LA1583 CD3 H RG5 H H CD3 LA344 RG6 CD3 CD3 H H CD3 LA1584 CD3 H RG6 H H CD3 LA345 RG7 CD3 CD3 H H CD3 LA1585 CD3 H RG7 H H CD3 LA346 RG8 CD3 CD3 H H CD3 LA1586 CD3 H RG8 H H CD3 LA347 RG9 CD3 CD3 H H CD3 LA1587 CD3 H RG9 H H CD3 LA348 RG10 CD3 CD3 H H CD3 LA1588 CD3 H RG10 H H CD3 LA349 RG11 CD3 CD3 H H CD3 LA1589 CD3 H RG11 H H CD3 LA350 RG12 CD3 CD3 H H CD3 LA1590 CD3 H RG12 H H CD3 LA351 RG13 CD3 CD3 H H CD3 LA1591 CD3 H RG13 H H CD3 LA352 RG14 CD3 CD3 H H CD3 LA1592 CD3 H RG14 H H CD3 LA353 RG15 CD3 CD3 H H CD3 LA1593 CD3 H RG15 H H CD3 LA354 RG16 CD3 CD3 H H CD3 LA1594 CD3 H RG16 H H CD3 LA355 RG17 CD3 CD3 H H CD3 LA1595 CD3 H RG17 H H CD3 LA356 RG18 CD3 CD3 H H CD3 LA1596 CD3 H RG18 H H CD3 LA357 RG19 CD3 CD3 H H CD3 LA1597 CD3 H RG19 H H CD3 LA358 RG20 CD3 CD3 H H CD3 LA1598 RG1 CD3 H H H H LA359 RG21 CD3 CD3 H H CD3 LA1599 RG2 CD3 H H H H LA360 RG22 CD3 CD3 H H CD3 LA1600 RG3 CD3 H H H H LA361 RG23 CD3 CD3 H H CD3 LA1601 RG4 CD3 H H H H LA362 RG24 CD3 CD3 H H CD3 LA1602 RG5 CD3 H H H H LA363 RG25 CD3 CD3 H H CD3 LA1603 RG6 CD3 H H H H LA364 RG26 CD3 CD3 H H CD3 LA1604 RG7 CD3 H H H H

Ligand RA1 RA2 RA3 RA4 RA5 RA6 Ligand RA1 RA2 RA3 RA4 RA5 RA6 LA365 RG27 CD3 CD3 H H CD3 LA1605 RG8 CD3 H H H H LA366 RG28 CD3 CD3 H H CD3 LA1606 RG9 CD3 H H H H LA367 RG29 CD3 CD3 H H CD3 LA1607 RG10 CD3 H H H H LA368 RG30 CD3 CD3 H H CD3 LA1608 RG11 CD3 H H H H LA369 RG31 CD3 CD3 H H CD3 LA1609 RG12 CD3 H H H H LA370 RG32 CD3 CD3 H H CD3 LA1610 RG13 CD3 H H H H LA371 RG33 CD3 CD3 H H CD3 LA1611 RG14 CD3 H H H H LA372 RG34 CD3 CD3 H H CD3 LA1612 RG15 CD3 H H H H LA373 RG35 CD3 CD3 H H CD3 LA1613 RG16 CD3 H H H H LA374 RG36 CD3 CD3 H H CD3 LA1614 RG17 CD3 H H H H LA375 RG37 CD3 CD3 H H CD3 LA1615 RG18 CD3 H H H H LA376 RG38 CD3 CD3 H H CD3 LA1616 RG19 CD3 H H H H LA377 RG39 CD3 CD3 H H CD3 LA1617 H CD3 RG1 H H CD3 LA378 RG40 CD3 CD3 H H CD3 LA1618 H CD3 RG2 H H CD3 LA379 RG41 CD3 CD3 H H CD3 LA1619 H CD3 RG3 H H CD3 LA380 RG42 CD3 CD3 H H CD3 LA1620 H CD3 RG4 H H CD3 LA381 RG43 CD3 CD3 H H CD3 LA1621 H CD3 RG5 H H CD3 LA382 RG44 CD3 CD3 H H CD3 LA1622 H CD3 RG6 H H CD3 LA383 RG45 CD3 CD3 H H CD3 LA1623 H CD3 RG7 H H CD3 LA384 RG46 CD3 CD3 H H CD3 LA1624 H CD3 RG8 H H CD3 LA385 RG47 CD3 CD3 H H CD3 LA1625 H CD3 RG9 H H CD3 LA386 RG48 CD3 CD3 H H CD3 LA1626 H CD3 RG10 H H CD3 LA387 RG49 CD3 CD3 H H CD3 LA1627 H CD3 RG11 H H CD3 LA388 RG50 CD3 CD3 H H CD3 LA1628 H CD3 RG12 H H CD3

Ligand RA1 RA2 RA3 RA4 RA5 RA6 Ligand RA1 RA2 RA3 RA4 RA5 RA6 LA389 RG51 CD3 CD3 H H CD3 LA1629 H CD3 RG13 H H CD3 LA390 RG52 CD3 CD3 H H CD3 LA1630 H CD3 RG14 H H CD3 LA391 RG53 CD3 CD3 H H CD3 LA1631 H CD3 RG15 H H CD3 LA392 RG54 CD3 CD3 H H CD3 LA1632 H CD3 RG16 H H CD3 LA393 RG55 CD3 CD3 H H CD3 LA1633 H CD3 RG17 H H CD3 LA394 RG56 CD3 CD3 H H CD3 LA1634 H CD3 RG18 H H CD3 LA395 RG57 CD3 CD3 H H CD3 LA1635 H CD3 RG19 H H CD3 LA396 RG58 CD3 CD3 H H CD3 LA1636 H RG1 H H H H LA397 RG59 CD3 CD3 H H CD3 LA1637 H RG2 H H H H LA398 RG60 CD3 CD3 H H CD3 LA1638 H RG3 H H H H LA399 RG61 CD3 CD3 H H CD3 LA1639 H RG4 H H H H LA400 RG62 CD3 CD3 H H CD3 LA1640 H RG5 H H H H LA401 RG63 CD3 CD3 H H CD3 LA1641 H RG6 H H H H LA402 RG64 CD3 CD3 H H CD3 LA1642 H RG7 H H H H LA403 RG65 CD3 CD3 H H CD3 LA1643 H RG8 H H H H LA404 RG66 CD3 CD3 H H CD3 LA1644 H RG9 H H H H LA405 RG67 CD3 CD3 H H CD3 LA1645 H RG10 H H H H LA406 RG68 CD3 CD3 H H CD3 LA1646 H RG11 H H H H LA407 RG69 CD3 CD3 H H CD3 LA1647 H RG12 H H H H LA408 RG70 CD3 CD3 H H CD3 LA1648 H RG13 H H H H LA409 RG71 CD3 CD3 H H CD3 LA1649 H RG14 H H H H LA410 RG72 CD3 CD3 H H CD3 LA1650 H RG15 H H H H LA411 RG73 CD3 CD3 H H CD3 LA1651 H RG16 H H H H LA412 RG74 CD3 CD3 H H CD3 LA1652 H RG17 H H H H

Ligand RA1 RA2 RA3 RA4 RA5 RA6 Ligand RA1 RA2 RA3 RA4 RA5 RA6 LA413 RG75 CD3 CD3 H H CD3 LA1653 H RG18 H H H H LA414 RG76 CD3 CD3 H H CD3 LA1654 H RG19 H H H H LA415 RG77 CD3 CD3 H H CD3 LA1655 H RG20 H H H H LA416 RG78 CD3 CD3 H H CD3 LA1656 H RG21 H H H H LA417 RG79 CD3 CD3 H H CD3 LA1657 H RG22 H H H H LA418 RG80 CD3 CD3 H H CD3 LA1658 H RG23 H H H H LA419 RG81 CD3 CD3 H H CD3 LA1659 H RG24 H H H H LA420 RG82 CD3 CD3 H H CD3 LA1660 H RG25 H H H H LA421 RG83 CD3 CD3 H H CD3 LA1661 H RG26 H H H H LA422 RG84 CD3 CD3 H H CD3 LA1662 H RG27 H H H H LA423 RG85 CD3 CD3 H H CD3 LA1663 H RG28 H H H H LA424 RG86 CD3 CD3 H H CD3 LA1664 H RG29 H H H H LA425 RG87 CD3 CD3 H H CD3 LA1665 H RG30 H H H H LA426 RG88 CD3 CD3 H H CD3 LA1666 H RG31 H H H H LA427 RG89 CD3 CD3 H H CD3 LA1667 H RG32 H H H H LA428 RG90 CD3 CD3 H H CD3 LA1668 H RG33 H H H H LA429 RG91 CD3 CD3 H H CD3 LA1669 H RG34 H H H H LA430 RG92 CD3 CD3 H H CD3 LA1670 H RG35 H H H H LA431 RG93 CD3 CD3 H H CD3 LA1671 H RG36 H H H H LA432 RG94 CD3 CD3 H H CD3 LA1672 H RG37 H H H H LA433 RG95 CD3 CD3 H H CD3 LA1673 H RG38 H H H H LA434 RG96 CD3 CD3 H H CD3 LA1674 H RG39 H H H H LA435 RG97 CD3 CD3 H H CD3 LA1675 H RG40 H H H H LA436 RG98 CD3 CD3 H H CD3 LA1676 H RG41 H H H H

Ligand RA1 RA2 RA3 RA4 RA5 RA6 Ligand RA1 RA2 RA3 RA4 RA5 RA6 LA437 RG99 CD3 CD3 H H CD3 LA1677 H RG42 H H H H LA438 RG100 CD3 CD3 H H CD3 LA1678 H RG43 H H H H LA439 RG101 CD3 CD3 H H CD3 LA1679 H RG44 H H H H LA440 RG102 CD3 CD3 H H CD3 LA1680 H RG45 H H H H LA441 RG103 CD3 CD3 H H CD3 LA1681 H RG46 H H H H LA442 RG104 CD3 CD3 H H CD3 LA1682 H RG47 H H H H LA443 RG105 CD3 CD3 H H CD3 LA1683 H RG48 H H H H LA444 RG106 CD3 CD3 H H CD3 LA1684 H RG49 H H H H LA445 RG107 CD3 CD3 H H CD3 LA1685 H RG50 H H H H LA446 RG108 CD3 CD3 H H CD3 LA1686 H RG51 H H H H LA447 RG109 CD3 CD3 H H CD3 LA1687 H RG52 H H H H LA448 RG110 CD3 CD3 H H CD3 LA1688 H RG53 H H H H LA449 RG111 CD3 CD3 H H CD3 LA1689 H RG54 H H H H LA450 RG112 CD3 CD3 H H CD3 LA1690 H RG55 H H H H LA451 RG113 CD3 CD3 H H CD3 LA1691 H RG56 H H H H LA452 RG114 CD3 CD3 H H CD3 LA1692 H RG57 H H H H LA453 RG115 CD3 CD3 H H CD3 LA1693 H RG58 H H H H LA454 RG116 CD3 CD3 H H CD3 LA1694 H RG59 H H H H LA455 RG117 CD3 CD3 H H CD3 LA1695 H RG60 H H H H LA456 RG118 CD3 CD3 H H CD3 LA1696 H RG61 H H H H LA457 RG119 CD3 CD3 H H CD3 LA1697 H RG62 H H H H LA458 RG120 CD3 CD3 H H CD3 LA1698 H RG63 H H H H LA459 RG121 CD3 CD3 H H CD3 LA1699 H RG64 H H H H LA460 RG122 CD3 CD3 H H CD3 LA1700 H RG65 H H H H

Ligand RA1 RA2 RA3 RA4 RA5 RA6 Ligand RA1 RA2 RA3 RA4 RA5 RA6 LA461 RG123 CD3 CD3 H H CD3 LA1701 H RG66 H H H H LA462 RG124 CD3 CD3 H H CD3 LA1702 H RG67 H H H H LA463 RG125 CD3 CD3 H H CD3 LA1703 H RG68 H H H H LA464 RG126 CD3 CD3 H H CD3 LA1704 H RG69 H H H H LA465 RG127 CD3 CD3 H H CD3 LA1705 H RG70 H H H H LA466 RG128 CD3 CD3 H H CD3 LA1706 H RG71 H H H H LA467 RG129 CD3 CD3 H H CD3 LA1707 H RG72 H H H H LA468 RG130 CD3 CD3 H H CD3 LA1708 H RG73 H H H H LA469 RG131 CD3 CD3 H H CD3 LA1709 H RG74 H H H H LA470 RG132 CD3 CD3 H H CD3 LA1710 H RG75 H H H H LA471 RG133 CD3 CD3 H H CD3 LA1711 H RG76 H H H H LA472 RG134 CD3 CD3 H H CD3 LA1712 H RG77 H H H H LA473 RG135 CD3 CD3 H H CD3 LA1713 H RG78 H H H H LA474 RG136 CD3 CD3 H H CD3 LA1714 H RG79 H H H H LA475 RG137 CD3 CD3 H H CD3 LA1715 H RG80 H H H H LA476 RG138 CD3 CD3 H H CD3 LA1716 H RG81 H H H H LA477 RG139 CD3 CD3 H H CD3 LA1717 H RG82 H H H H LA478 RG140 CD3 CD3 H H CD3 LA1718 H RG83 H H H H LA479 RG141 CD3 CD3 H H CD3 LA1719 H RG84 H H H H LA480 RG142 CD3 CD3 H H CD3 LA1720 H RG85 H H H H LA481 RG143 CD3 CD3 H H CD3 LA1721 H RG86 H H H H LA482 RG144 CD3 CD3 H H CD3 LA1722 H RG87 H H H H LA483 RG145 CD3 CD3 H H CD3 LA1723 H RG88 H H H H LA484 RG146 CD3 CD3 H H CD3 LA1724 H RG89 H H H H

Ligand RA1 RA2 RA3 RA4 RA5 RA6 Ligand RA1 RA2 RA3 RA4 RA5 RA6 LA485 RG147 CD3 CD3 H H CD3 LA1725 H RG90 H H H H LA486 RG148 CD3 CD3 H H CD3 LA1726 H RG91 H H H H LA487 RG149 CD3 CD3 H H CD3 LA1727 H RG92 H H H H LA488 RG150 CD3 CD3 H H CD3 LA1728 H RG93 H H H H LA489 RG151 CD3 CD3 H H CD3 LA1729 H RG94 H H H H LA490 RG152 CD3 CD3 H H CD3 LA1730 H RG95 H H H H LA491 RG153 CD3 CD3 H H CD3 LA1731 H RG96 H H H H LA492 RG154 CD3 CD3 H H CD3 LA1732 H RG97 H H H H LA493 RG155 CD3 CD3 H H CD3 LA1733 H RG98 H H H H LA494 RG156 CD3 CD3 H H CD3 LA1734 H RG99 H H H H LA495 RG157 CD3 CD3 H H CD3 LA1735 H RG100 H H H H LA496 RG158 CD3 CD3 H H CD3 LA1736 H RG101 H H H H LA497 RG159 CD3 CD3 H H CD3 LA1737 H RG102 H H H H LA498 RG160 CD3 CD3 H H CD3 LA1738 H RG103 H H H H LA499 RG161 CD3 CD3 H H CD3 LA1739 H RG104 H H H H LA500 RG162 CD3 CD3 H H CD3 LA1740 H RG105 H H H H LA501 RG163 CD3 CD3 H H CD3 LA1741 H RG106 H H H H LA502 RG164 CD3 CD3 H H CD3 LA1742 H RG107 H H H H LA503 RG165 CD3 CD3 H H CD3 LA1743 H RG108 H H H H LA504 RG166 CD3 CD3 H H CD3 LA1744 H RG109 H H H H LA505 RG167 CD3 CD3 H H CD3 LA1745 H RG110 H H H H LA506 RG168 CD3 CD3 H H CD3 LA1746 H RG111 H H H H LA507 RG169 CD3 CD3 H H CD3 LA1747 H RG112 H H H H LA508 H RG1 CD3 H H H LA1748 H RG113 H H H H

Ligand RA1 RA2 RA3 RA4 RA5 RA6 Ligand RA1 RA2 RA3 RA4 RA5 RA6 LA509 H RG2 CD3 H H H LA1749 H RG114 H H H H LA510 H RG3 CD3 H H H LA1750 H RG115 H H H H LA511 H RG4 CD3 H H H LA1751 H RG116 H H H H LA512 H RG5 CD3 H H H LA1752 H RG117 H H H H LA513 H RG6 CD3 H H H LA1753 H RG118 H H H H LA514 H RG7 CD3 H H H LA1754 H RG119 H H H H LA515 H RG8 CD3 H H H LA1755 H RG120 H H H H LA516 H RG9 CD3 H H H LA1756 H RG121 H H H H LA517 H RG10 CD3 H H H LA1757 H RG122 H H H H LA518 H RG11 CD3 H H H LA1758 H RG123 H H H H LA519 H RG12 CD3 H H H LA1759 H RG124 H H H H LA520 H RG13 CD3 H H H LA1760 H RG125 H H H H LA521 H RG14 CD3 H H H LA1761 H RG126 H H H H LA522 H RG15 CD3 H H H LA1762 H RG127 H H H H LA523 H RG16 CD3 H H H LA1763 H RG128 H H H H LA524 H RG17 CD3 H H H LA1764 H RG129 H H H H LA525 H RG18 CD3 H H H LA1765 H RG130 H H H H LA526 H RG19 CD3 H H H LA1766 H RG131 H H H H LA527 H RG20 CD3 H H H LA1767 H RG132 H H H H LA528 H RG21 CD3 H H H LA1768 H RG133 H H H H LA529 H RG22 CD3 H H H LA1769 H RG134 H H H H LA530 H RG23 CD3 H H H LA1770 H RG135 H H H H LA531 H RG24 CD3 H H H LA1771 H RG136 H H H H LA532 H RG25 CD3 H H H LA1772 H RG137 H H H H

Ligand RA1 RA2 RA3 RA4 RA5 RA6 Ligand RA1 RA2 RA3 RA4 RA5 RA6 LA533 H RG26 CD3 H H H LA1773 H RG138 H H H H LA534 H RG27 CD3 H H H LA1774 H RG139 H H H H LA535 H RG28 CD3 H H H LA1775 H RG140 H H H H LA536 H RG29 CD3 H H H LA1776 H RG141 H H H H LA537 H RG30 CD3 H H H LA1777 H RG142 H H H H LA538 H RG31 CD3 H H H LA1778 H RG143 H H H H LA539 H RG32 CD3 H H H LA1779 H RG144 H H H H LA540 H RG33 CD3 H H H LA1780 H RG145 H H H H LA541 H RG34 CD3 H H H LA1781 H RG146 H H H H LA542 H RG35 CD3 H H H LA1782 H RG147 H H H H LA543 H RG36 CD3 H H H LA1783 H RG148 H H H H LA544 H RG37 CD3 H H H LA1784 H RG149 H H H H LA545 H RG38 CD3 H H H LA1785 H RG150 H H H H LA546 H RG39 CD3 H H H LA1786 H RG151 H H H H LA547 H RG40 CD3 H H H LA1787 H RG152 H H H H LA548 H RG41 CD3 H H H LA1788 H RG153 H H H H LA549 H RG42 CD3 H H H LA1789 H RG154 H H H H LA550 H RG43 CD3 H H H LA1790 H RG155 H H H H LA551 H RG44 CD3 H H H LA1791 H RG156 H H H H LA552 H RG45 CD3 H H H LA1792 H RG157 H H H H LA553 H RG46 CD3 H H H LA1793 H RG158 H H H H LA554 H RG47 CD3 H H H LA1794 H RG159 H H H H LA555 H RG48 CD3 H H H LA1795 H RG160 H H H H LA556 H RG49 CD3 H H H LA1796 H RG161 H H H H

Ligand RA1 RA2 RA3 RA4 RA5 RA6 Ligand RA1 RA2 RA3 RA4 RA5 RA6 LA557 H RG50 CD3 H H H LA1797 H RG162 H H H H LA558 H RG51 CD3 H H H LA1798 H RG163 H H H H LA559 H RG52 CD3 H H H LA1799 H RG164 H H H H LA560 H RG53 CD3 H H H LA1800 H RG165 H H H H LA561 H RG54 CD3 H H H LA1801 H RG166 H H H H LA562 H RG55 CD3 H H H LA1802 H RG167 H H H H LA563 H RG56 CD3 H H H LA1803 H RG168 H H H H LA564 H RG57 CD3 H H H LA1804 H RG169 H H H H LA565 H RG58 CD3 H H H LA1805 H H RG1 H H H LA566 H RG59 CD3 H H H LA1806 H H RG2 H H H LA567 H RG60 CD3 H H H LA1807 H H RG3 H H H LA568 H RG61 CD3 H H H LA1808 H H RG4 H H H LA569 H RG62 CD3 H H H LA1809 H H RG5 H H H LA570 H RG63 CD3 H H H LA1810 H H RG6 H H H LA571 H RG64 CD3 H H H LA1811 H H RG7 H H H LA572 H RG65 CD3 H H H LA1812 H H RG8 H H H LA573 H RG66 CD3 H H H LA1813 H H RG9 H H H LA574 H RG67 CD3 H H H LA1814 H H RG10 H H H LA575 H RG68 CD3 H H H LA1815 H H RG11 H H H LA576 H RG69 CD3 H H H LA1816 H H RG12 H H H LA577 H RG70 CD3 H H H LA1817 H H RG13 H H H LA578 H RG71 CD3 H H H LA1818 H H RG14 H H H LA579 H RG72 CD3 H H H LA1819 H H RG15 H H H LA580 H RG73 CD3 H H H LA1820 H H RG16 H H H

Ligand RA1 RA2 RA3 RA4 RA5 RA6 Ligand RA1 RA2 RA3 RA4 RA5 RA6 LA581 H RG74 CD3 H H H LA1821 H H RG17 H H H LA582 H RG75 CD3 H H H LA1822 H H RG18 H H H LA583 H RG76 CD3 H H H LA1823 H H RG19 H H H LA584 H RG77 CD3 H H H LA1824 H H RG20 H H H LA585 H RG78 CD3 H H H LA1825 H H RG21 H H H LA586 H RG79 CD3 H H H LA1826 H H RG22 H H H LA587 H RG80 CD3 H H H LA1827 H H RG23 H H H LA588 H RG81 CD3 H H H LA1828 H H RG24 H H H LA589 H RG82 CD3 H H H LA1829 H H RG25 H H H LA590 H RG83 CD3 H H H LA1830 H H RG26 H H H LA591 H RG84 CD3 H H H LA1831 H H RG27 H H H LA592 H RG85 CD3 H H H LA1832 H H RG28 H H H LA593 H RG86 CD3 H H H LA1833 H H RG29 H H H LA594 H RG87 CD3 H H H LA1834 H H RG30 H H H LA595 H RG88 CD3 H H H LA1835 H H RG31 H H H LA596 H RG89 CD3 H H H LA1836 H H RG32 H H H LA597 H RG90 CD3 H H H LA1837 H H RG33 H H H LA598 H RG91 CD3 H H H LA1838 H H RG34 H H H LA599 H RG92 CD3 H H H LA1839 H H RG35 H H H LA600 H RG93 CD3 H H H LA1840 H H RG36 H H H LA601 H RG94 CD3 H H H LA1841 H H RG37 H H H LA602 H RG95 CD3 H H H LA1842 H H RG38 H H H LA603 H RG96 CD3 H H H LA1843 H H RG39 H H H LA604 H RG97 CD3 H H H LA1844 H H RG40 H H H

Ligand RA1 RA2 RA3 RA4 RA5 RA6 Ligand RA1 RA2 RA3 RA4 RA5 RA6 LA605 H RG98 CD3 H H H LA1845 H H RG41 H H H LA606 H RG99 CD3 H H H LA1846 H H RG42 H H H LA607 H RG100 CD3 H H H LA1847 H H RG43 H H H LA608 H RG101 CD3 H H H LA1848 H H RG44 H H H LA609 H RG102 CD3 H H H LA1849 H H RG45 H H H LA610 H RG103 CD3 H H H LA1850 H H RG46 H H H LA611 H RG104 CD3 H H H LA1851 H H RG47 H H H LA612 H RG105 CD3 H H H LA1852 H H RG48 H H H LA613 H RG106 CD3 H H H LA1853 H H RG49 H H H LA614 H RG107 CD3 H H H LA1854 H H RG50 H H H LA615 H RG108 CD3 H H H LA1855 H H RG51 H H H LA616 H RG109 CD3 H H H LA1856 H H RG52 H H H LA617 H RG110 CD3 H H H LA1857 H H RG53 H H H LA618 H RG111 CD3 H H H LA1858 H H RG54 H H H LA619 H RG112 CD3 H H H LA1859 H H RG55 H H H LA620 H RG113 CD3 H H H LA1860 H H RG56 H H H LA621 H RG114 CD3 H H H LA1861 H H RG57 H H H LA622 H RG115 CD3 H H H LA1862 H H RG58 H H H LA623 H RG116 CD3 H H H LA1863 H H RG59 H H H LA624 H RG117 CD3 H H H LA1864 H H RG60 H H H LA625 H RG118 CD3 H H H LA1865 H H RG61 H H H LA626 H RG119 CD3 H H H LA1866 H H RG62 H H H LA627 H RG120 CD3 H H H LA1867 H H RG63 H H H LA628 H RG121 CD3 H H H LA1868 H H RG64 H H H

Ligand RA1 RA2 RA3 RA4 RA5 RA6 Ligand RA1 RA2 RA3 RA4 RA5 RA6 LA629 H RG122 CD3 H H H LA1869 H H RG65 H H H LA630 H RG123 CD3 H H H LA1870 H H RG66 H H H LA631 H RG124 CD3 H H H LA1871 H H RG67 H H H LA632 H RG125 CD3 H H H LA1872 H H RG68 H H H LA633 H RG126 CD3 H H H LA1873 H H RG69 H H H LA634 H RG127 CD3 H H H LA1874 H H RG70 H H H LA635 H RG128 CD3 H H H LA1875 H H RG71 H H H LA636 H RG129 CD3 H H H LA1876 H H RG72 H H H LA637 H RG130 CD3 H H H LA1877 H H RG73 H H H LA638 H RG131 CD3 H H H LA1878 H H RG74 H H H LA639 H RG132 CD3 H H H LA1879 H H RG75 H H H LA640 H RG133 CD3 H H H LA1880 H H RG76 H H H LA641 H RG134 CD3 H H H LA1881 H H RG77 H H H LA642 H RG135 CD3 H H H LA1882 H H RG78 H H H LA643 H RG136 CD3 H H H LA1883 H H RG79 H H H LA644 H RG137 CD3 H H H LA1884 H H RG80 H H H LA645 H RG133 CD3 H H H LA1885 H H RG81 H H H LA646 H RG139 CD3 H H H LA1886 H H RG82 H H H LA647 H RG140 CD3 H H H LA1887 H H RG83 H H H LA648 H RG141 CD3 H H H LA1888 H H RG84 H H H LA649 H RG142 CD3 H H H LA1889 H H RG85 H H H LA650 H RG143 CD3 H H H LA1890 H H RG86 H H H LA651 H RG144 CD3 H H H LA1891 H H RG87 H H H LA652 H RG145 CD3 H H H LA1892 H H RG88 H H H

Ligand RA1 RA2 RA3 RA4 RA5 RA6 Ligand RA1 RA2 RA3 RA4 RA5 RA6 LA653 H RG146 CD3 H H H LA1893 H H RG89 H H H LA654 H RG147 CD3 H H H LA1894 H H RG90 H H H LA655 H RG148 CD3 H H H LA1895 H H RG91 H H H LA656 H RG149 CD3 H H H LA1896 H H RG92 H H H LA657 H RG150 CD3 H H H LA1897 H H RG93 H H H LA658 H RG151 CD3 H H H LA1898 H H RG94 H H H LA659 H RG152 CD3 H H H LA1899 H H RG95 H H H LA660 H RG153 CD3 H H H LA1900 H H RG96 H H H LA661 H RG154 CD3 H H H LA1901 H H RG97 H H H LA662 H RG155 CD3 H H H LA1902 H H RG98 H H H LA663 H RG156 CD3 H H H LA1903 H H RG99 H H H LA664 H RG157 CD3 H H H LA1904 H H RG100 H H H LA665 H RG158 CD3 H H H LA1905 H H RG101 H H H LA666 H RG159 CD3 H H H LA1906 H H RG102 H H H LA667 H RG160 CD3 H H H LA1907 H H RG103 H H H LA668 H RG161 CD3 H H H LA1908 H H RG104 H H H LA669 H RG162 CD3 H H H LA1909 H H RG105 H H H LA670 H RG163 CD3 H H H LA1910 H H RG106 H H H LA671 H RG164 CD3 H H H LA1911 H H RG107 H H H LA672 H RG165 CD3 H H H LA1912 H H RG108 H H H LA673 H RG166 CD3 H H H LA1913 H H RG109 H H H LA674 H RG167 CD3 H H H LA1914 H H RG110 H H H LA675 H RG168 CD3 H H H LA1915 H H RG111 H H H LA676 H RG169 CD3 H H H LA1916 H H RG112 H H H

Ligand RA1 RA2 RA3 RA4 RA5 RA6 Ligand RA1 RA2 RA3 RA4 RA5 RA6 LA677 CD3 RG1 CD3 H H CD3 LA1917 H H RG113 H H H LA678 CD3 RG2 CD3 H H CD3 LA1918 H H RG114 H H H LA679 CD3 RG3 CD3 H H CD3 LA1919 H H RG115 H H H LA680 CD3 RG4 CD3 H H CD3 LA1920 H H RG116 H H H LA681 CD3 RG5 CD3 H H CD3 LA1921 H H RG117 H H H LA682 CD3 RG6 CD3 H H CD3 LA1922 H H RG118 H H H LA683 CD3 RG7 CD3 H H CD3 LA1923 H H RG119 H H H LA684 CD3 RG8 CD3 H H CD3 LA1924 H H RG120 H H H LA685 CD3 RG9 CD3 H H CD3 LA1925 H H RG121 H H H LA686 CD3 RG10 CD3 H H CD3 LA1926 H H RG122 H H H LA687 CD3 RG11 CD3 H H CD3 LA1927 H H RG123 H H H LA688 CD3 RG12 CD3 H H CD3 LA1928 H H RG124 H H H LA689 CD3 RG13 CD3 H H CD3 LA1929 H H RG125 H H H LA690 CD3 RG14 CD3 H H CD3 LA1930 H H RG126 H H H LA691 CD3 RG15 CD3 H H CD3 LA1931 H H RG127 H H H LA692 CD3 RG16 CD3 H H CD3 LA1932 H H RG128 H H H LA693 CD3 RG17 CD3 H H CD3 LA1933 H H RG129 H H H LA694 CD3 RG18 CD3 H H CD3 LA1934 H H RG130 H H H LA695 CD3 RG19 CD3 H H CD3 LA1935 H H RG131 H H H LA696 CD3 RG20 CD3 H H CD3 LA1936 H H RG132 H H H LA697 CD3 RG21 CD3 H H CD3 LA1937 H H RG133 H H H LA698 CD3 RG22 CD3 H H CD3 LA1938 H H RG134 H H H LA699 CD3 RG23 CD3 H H CD3 LA1939 H H RG135 H H H LA700 CD3 RG24 CD3 H H CD3 LA1940 H H RG136 H H H

Ligand RA1 RA2 RA3 RA4 RA5 RA6 Ligand RA1 RA2 RA3 RA4 RA5 RA6 LA701 CD3 RG25 CD3 H H CD3 LA1941 H H RG137 H H H LA702 CD3 RG26 CD3 H H CD3 LA1942 H H RG138 H H H LA703 CD3 RG27 CD3 H H CD3 LA1943 H H RG139 H H H LA704 CD3 RG28 CD3 H H CD3 LA1944 H H RG140 H H H LA705 CD3 RG29 CD3 H H CD3 LA1945 H H RG141 H H H LA706 CD3 RG30 CD3 H H CD3 LA1946 H H RG142 H H H LA707 CD3 RG31 CD3 H H CD3 LA1947 H H RG143 H H H LA708 CD3 RG32 CD3 H H CD3 LA1948 H H RG144 H H H LA709 CD3 RG33 CD3 H H CD3 LA1949 H H RG145 H H H LA710 CD3 RG34 CD3 H H CD3 LA1950 H H RG146 H H H LA711 CD3 RG35 CD3 H H CD3 LA1951 H H RG147 H H H LA712 CD3 RG36 CD3 H H CD3 LA1952 H H RG148 H H H LA713 CD3 RG37 CD3 H H CD3 LA1953 H H RG149 H H H LA714 CD3 RG38 CD3 H H CD3 LA1954 H H RG150 H H H LA715 CD3 RG39 CD3 H H CD3 LA1955 H H RG151 H H H LA716 CD3 RG40 CD3 H H CD3 LA1956 H H RG152 H H H LA717 CD3 RG41 CD3 H H CD3 LA1957 H H RG153 H H H LA718 CD3 RG42 CD3 H H CD3 LA1958 H H RG154 H H H LA719 CD3 RG43 CD3 H H CD3 LA1959 H H RG155 H H H LA720 CD3 RG44 CD3 H H CD3 LA1960 H H RG156 H H H LA721 CD3 RG45 CD3 H H CD3 LA1961 H H RG157 H H H LA722 CD3 RG46 CD3 H H CD3 LA1962 H H RG158 H H H LA723 CD3 RG47 CD3 H H CD3 LA1963 H H RG159 H H H LA724 CD3 RG48 CD3 H H CD3 LA1964 H H RG160 H H H

Ligand RA1 RA2 RA3 RA4 RA5 RA6 Ligand RA1 RA2 RA3 RA4 RA5 RA6 LA725 CD3 RG49 CD3 H H CD3 LA1965 H H RG161 H H H LA726 CD3 RG50 CD3 H H CD3 LA1966 H H RG162 H H H LA727 CD3 RG51 CD3 H H CD3 LA1967 H H RG163 H H H LA728 CD3 RG52 CD3 H H CD3 LA1968 H H RG164 H H H LA729 CD3 RG53 CD3 H H CD3 LA1969 H H RG165 H H H LA730 CD3 RG54 CD3 H H CD3 LA1970 H H RG166 H H H LA731 CD3 RG55 CD3 H H CD3 LA1971 H H RG167 H H H LA732 CD3 RG56 CD3 H H CD3 LA1972 H H RG168 H H H LA733 CD3 RG57 CD3 H H CD3 LA1973 H H RG169 H H H LA734 CD3 RGS8 CD3 H H CD3 LA1974 H H H RG1 H H LA735 CD3 RG59 CD3 H H CD3 LA1975 H H H RG2 H H LA736 CD3 RG60 CD3 H H CD3 LA1976 H H H RG3 H H LA737 CD3 RG61 CD3 H H CD3 LA1977 H H H RG4 H H LA738 CD3 RG62 CD3 H H CD3 LA1978 H H H RG5 H H LA739 CD3 RG63 CD3 H H CD3 LA1979 H H H RG6 H H LA740 CD3 RG64 CD3 H H CD3 LA1980 H H H RG7 H H LA741 CD3 RG65 CD3 H H CD3 LA1981 H H H RG8 H H LA742 CD3 RG66 CD3 H H CD3 LA1982 H H H RG9 H H LA743 CD3 RG67 CD3 H H CD3 LA1983 H H H RG10 H H LA744 CD3 RG68 CD3 H H CD3 LA1984 H H H RG11 H H LA745 CD3 RG69 CD3 H H CD3 LA1985 H H H RG12 H H LA746 CD3 RG70 CD3 H H CD3 LA1986 H H H RG13 H H LA747 CD3 RG71 CD3 H H CD3 LA1987 H H H RG14 H H LA748 CD3 RG72 CD3 H H CD3 LA1988 H H H RG15 H H

Ligand RA1 RA2 RA3 RA4 RA5 RA6 Ligand RA1 RA2 RA3 RA4 RA5 RA6 LA749 CD3 RG73 CD3 H H CD3 LA1989 H H H RG16 H H LA750 CD3 RG74 CD3 H H CD3 LA1990 H H H RG17 H H LA751 CD3 RG75 CD3 H H CD3 LA1991 H H H RG18 H H LA752 CD3 RG76 CD3 H H CD3 LA1992 H H H RG19 H H LA753 CD3 RG77 CD3 H H CD3 LA1993 H H H RG20 H H LA754 CD3 RG78 CD3 H H CD3 LA1994 H H H RG21 H H LA755 CD3 RG79 CD3 H H CD3 LA1995 H H H RG22 H H LA756 CD3 RG80 CD3 H H CD3 LA1996 H H H RG23 H H LA757 CD3 RG81 CD3 H H CD3 LA1997 H H H RG24 H H LA758 CD3 RG82 CD3 H H CD3 LA1998 H H H RG25 H H LA759 CD3 RG83 CD3 H H CD3 LA1999 H H H RG26 H H LA760 CD3 RG84 CD3 H H CD3 LA2000 H H H RG27 H H LA761 CD3 RG85 CD3 H H CD3 LA2001 H H H RG28 H H LA762 CD3 RG86 CD3 H H CD3 LA2002 H H H RG29 H H LA763 CD3 RG87 CD3 H H CD3 LA2003 H H H RG30 H H LA764 CD3 RG88 CD3 H H CD3 LA2004 H H H RG31 H H LA765 CD3 RG89 CD3 H H CD3 LA2005 H H H RG32 H H LA766 CD3 RG90 CD3 H H CD3 LA2006 H H H RG33 H H LA767 CD3 RG91 CD3 H H CD3 LA2007 H H H RG34 H H LA768 CD3 RG92 CD3 H H CD3 LA2008 H H H RG35 H H LA769 CD3 RG93 CD3 H H CD3 LA2009 H H H RG36 H H LA770 CD3 RG94 CD3 H H CD3 LA2010 H H H RG37 H H LA771 CD3 RG95 CD3 H H CD3 LA2011 H H H RG38 H H LA772 CD3 RG96 CD3 H H CD3 LA2012 H H H RG39 H H

Ligand RA1 RA2 RA3 RA4 RA5 RA6 Ligand RA1 RA2 RA3 RA4 RA5 RA6 LA773 CD3 RG97 CD3 H H CD3 LA2013 H H H RG40 H H LA774 CD3 RG98 CD3 H H CD3 LA2014 H H H RG41 H H LA775 CD3 RG99 CD3 H H CD3 LA2015 H H H RG42 H H LA776 CD3 RG100 CD3 H H CD3 LA2016 H H H RG43 H H LA777 CD3 RG101 CD3 H H CD3 LA2017 H H H RG44 H H LA778 CD3 RG102 CD3 H H CD3 LA2018 H H H RG45 H H LA779 CD3 RG103 CD3 H H CD3 LA2019 H H H RG46 H H LA780 CD3 RG104 CD3 H H CD3 LA2020 H H H RG47 H H LA781 CD3 RG105 CD3 H H CD3 LA2021 H H H RG48 H H LA782 CD3 RG106 CD3 H H CD3 LA2022 H H H RG49 H H LA783 CD3 RG107 CD3 H H CD3 LA2023 H H H RG50 H H LA784 CD3 RG108 CD3 H H CD3 LA2024 H H H RG51 H H LA785 CD3 RG109 CD3 H H CD3 LA2025 H H H RG52 H H LA786 CD3 RG110 CD3 H H CD3 LA2026 H H H RG53 H H LA787 CD3 RG111 CD3 H H CD3 LA2027 H H H RG54 H H LA788 CD3 RG112 CD3 H H CD3 LA2028 H H H RG55 H H LA789 CD3 RG113 CD3 H H CD3 LA2029 H H H RG56 H H LA790 CD3 RG114 CD3 H H CD3 LA2030 H H H RG57 H H LA791 CD3 RG115 CD3 H H CD3 LA2031 H H H RGS8 H H LA792 CD3 RG116 CD3 H H CD3 LA2032 H H H RG59 H H LA793 CD3 RG117 CD3 H H CD3 LA2033 H H H RG60 H H LA794 CD3 RG118 CD3 H H CD3 LA2034 H H H RG61 H H LA795 CD3 RG119 CD3 H H CD3 LA2035 H H H RG62 H H LA796 CD3 RG120 CD3 H H CD3 LA2036 H H H RG63 H H

Ligand RA1 RA2 RA3 RA4 RA5 RA6 Ligand RA1 RA2 RA3 RA4 RA5 RA6 LA797 CD3 RG121 CD3 H H CD3 LA2037 H H H RG64 H H LA798 CD3 RG122 CD3 H H CD3 LA2038 H H H RG65 H H LA799 CD3 RG123 CD3 H H CD3 LA2039 H H H RG66 H H LA800 CD3 RG124 CD3 H H CD3 LA2040 H H H RG67 H H LA801 CD3 RG125 CD3 H H CD3 LA2041 H H H RG68 H H LA802 CD3 RG126 CD3 H H CD3 LA2042 H H H RG69 H H LA803 CD3 RG127 CD3 H H CD3 LA2043 H H H RG70 H H LA804 CD3 RG128 CD3 H H CD3 LA2044 H H H RG71 H H LA805 CD3 RG129 CD3 H H CD3 LA2045 H H H RG72 H H LA806 CD3 RG130 CD3 H H CD3 LA2046 H H H RG73 H H LA807 CD3 RG131 CD3 H H CD3 LA2047 H H H RG74 H H LA808 CD3 RG132 CD3 H H CD3 LA2048 H H H RG75 H H LA809 CD3 RG133 CD3 H H CD3 LA2049 H H H RG76 H H LA810 CD3 RG134 CD3 H H CD3 LA2050 H H H RG77 H H LA811 CD3 RG135 CD3 H H CD3 LA2051 H H H RG78 H H LA812 CD3 RG136 CD3 H H CD3 LA2052 H H H RG79 H H LA813 CD3 RG137 CD3 H H CD3 LA2053 H H H RG80 H H LA814 CD3 RG138 CD3 H H CD3 LA2054 H H H RG81 H H LA815 CD3 RG139 CD3 H H CD3 LA2055 H H H RG82 H H LA816 CD3 RG140 CD3 H H CD3 LA2056 H H H RG83 H H LA817 CD3 RG141 CD3 H H CD3 LA2057 H H H RG84 H H LA818 CD3 RG142 CD3 H H CD3 LA2058 H H H RG85 H H LA819 CD3 RG143 CD3 H H CD3 LA2059 H H H RG86 H H LA820 CD3 RG144 CD3 H H CD3 LA2060 H H H RG87 H H

Ligand RA1 RA2 RA3 RA4 RA5 RA6 Ligand RA1 RA2 RA3 RA4 RA5 RA6 LA821 CD3 RG145 CD3 H H CD3 LA2061 H H H RG88 H H LA822 CD3 RG146 CD3 H H CD3 LA2062 H H H RG89 H H LA823 CD3 RG147 CD3 H H CD3 LA2063 H H H RG90 H H LA824 CD3 RG148 CD3 H H CD3 LA2064 H H H RG91 H H LA825 CD3 RG149 CD3 H H CD3 LA2065 H H H RG92 H H LA826 CD3 RG150 CD3 H H CD3 LA2066 H H H RG93 H H LA827 CD3 RG151 CD3 H H CD3 LA2067 H H H RG94 H H LA828 CD3 RG152 CD3 H H CD3 LA2068 H H H RG95 H H LA829 CD3 RG153 CD3 H H CD3 LA2069 H H H RG96 H H LA830 CD3 RG154 CD3 H H CD3 LA2070 H H H RG97 H H LA831 CD3 RG155 CD3 H H CD3 LA2071 H H H RG98 H H LA832 CD3 RG156 CD3 H H CD3 LA2072 H H H RG99 H H LA833 CD3 RG157 CD3 H H CD3 LA2073 H H H RG100 H H LA834 CD3 RG158 CD3 H H CD3 LA2074 H H H RG101 H H LA835 CD3 RG159 CD3 H H CD3 LA2075 H H H RG102 H H LA836 CD3 RG160 CD3 H H CD3 LA2076 H H H RG103 H H LA837 CD3 RG161 CD3 H H CD3 LA2077 H H H RG104 H H LA838 CD3 RG162 CD3 H H CD3 LA2078 H H H RG105 H H LA839 CD3 RG163 CD3 H H CD3 LA2079 H H H RG106 H H LA840 CD3 RG164 CD3 H H CD3 LA2080 H H H RG107 H H LA841 CD3 RG165 CD3 H H CD3 LA2081 H H H RG108 H H LA842 CD3 RG166 CD3 H H CD3 LA2082 H H H RG109 H H LA843 CD3 RG167 CD3 H H CD3 LA2083 H H H RG110 H H LA844 CD3 RG168 CD3 H H CD3 LA2084 H H H RG111 H H

Ligand RA1 RA2 RA3 RA4 RA5 RA6 Ligand RA1 RA2 RA3 RA4 RA5 RA6 LA845 CD3 RG169 CD3 H H CD3 LA2085 H H H RG112 H H LA846 CD3 RG1 CD3 H H H LA2086 H H H RG113 H H LA847 CD3 RG2 CD3 H H H LA2087 H H H RG114 H H LA848 CD3 RG3 CD3 H H H LA2088 H H H RG115 H H LA849 CD3 RG4 CD3 H H H LA2089 H H H RG116 H H LA850 CD3 RG5 CD3 H H H LA2090 H H H RG117 H H LA851 CD3 RG6 CD3 H H H LA2091 H H H RG118 H H LA852 CD3 RG7 CD3 H H H LA2092 H H H RG119 H H LA853 CD3 RG8 CD3 H H H LA2093 H H H RG120 H H LA854 CD3 RG9 CD3 H H H LA2094 H H H RG121 H H LA855 CD3 RG10 CD3 H H H LA2095 H H H RG122 H H LA856 CD3 RG11 CD3 H H H LA2096 H H H RG123 H H LA857 CD3 RG12 CD3 H H H LA2097 H H H RG124 H H LA858 CD3 RG13 CD3 H H H LA2098 H H H RG125 H H LA859 CD3 RG14 CD3 H H H LA2099 H H H RG126 H H LA860 CD3 RG15 CD3 H H H LA2100 H H H RG127 H H LA861 CD3 RG16 CD3 H H H LA2101 H H H RG128 H H LA862 CD3 RG17 CD3 H H H LA2102 H H H RG129 H H LA863 CD3 RG18 CD3 H H H LA2103 H H H RG130 H H LA864 CD3 RG19 CD3 H H H LA2104 H H H RG131 H H LA865 CD3 RG20 CD3 H H H LA2105 H H H RG132 H H LA866 CD3 RG21 CD3 H H H LA2106 H H H RG133 H H LA867 CD3 RG22 CD3 H H H LA2107 H H H RG134 H H LA868 CD3 RG23 CD3 H H H LA2108 H H H RG135 H H

Ligand RA1 RA2 RA3 RA4 RA5 RA6 Ligand RA1 RA2 RA3 RA4 RA5 RA6 LA869 CD3 RG24 CD3 H H H LA2109 H H H RG136 H H LA870 CD3 RG25 CD3 H H H LA2110 H H H RG137 H H LA871 CD3 RG26 CD3 H H H LA2111 H H H RG138 H H LA872 CD3 RG27 CD3 H H H LA2112 H H H RG139 H H LA873 CD3 RG28 CD3 H H H LA2113 H H H RG140 H H LA874 CD3 RG29 CD3 H H H LA2114 H H H RG141 H H LA875 CD3 RG30 CD3 H H H LA2115 H H H RG142 H H LA876 CD3 RG31 CD3 H H H LA2116 H H H RG143 H H LA877 CD3 RG32 CD3 H H H LA2117 H H H RG144 H H LA878 CD3 RG33 CD3 H H H LA2118 H H H RG145 H H LA879 CD3 RG34 CD3 H H H LA2119 H H H RG146 H H LA880 CD3 RG35 CD3 H H H LA2120 H H H RG147 H H LA881 CD3 RG36 CD3 H H H LA2121 H H H RG148 H H LA882 CD3 RG37 CD3 H H H LA2122 H H H RG149 H H LA883 CD3 RG38 CD3 H H H LA2123 H H H RG150 H H LA884 CD3 RG39 CD3 H H H LA2124 H H H RG151 H H LA885 CD3 RG40 CD3 H H H LA2125 H H H RG152 H H LA886 CD3 RG41 CD3 H H H LA2126 H H H RG153 H H LA887 CD3 RG42 CD3 H H H LA2127 H H H RG154 H H LA888 CD3 RG43 CD3 H H H LA2128 H H H RG155 H H LA889 CD3 RG44 CD3 H H H LA2129 H H H RG156 H H LA890 CD3 RG45 CD3 H H H LA2130 H H H RG157 H H LA891 CD3 RG46 CD3 H H H LA2131 H H H RG158 H H LA892 CD3 RG47 CD3 H H H LA2132 H H H RG159 H H

Ligand RA1 RA2 RA3 RA4 RA5 RA6 Ligand RA1 RA2 RA3 RA4 RA5 RA6 LA893 CD3 RG48 CD3 H H H LA2133 H H H RG160 H H LA894 CD3 RG49 CD3 H H H LA2134 H H H RG161 H H LA895 CD3 RG50 CD3 H H H LA2135 H H H RG162 H H LA896 CD3 RG51 CD3 H H H LA2136 H H H RG163 H H LA897 CD3 RG52 CD3 H H H LA2137 H H H RG164 H H LA898 CD3 RG53 CD3 H H H LA2138 H H H RG165 H H LA899 CD3 RG54 CD3 H H H LA2139 H H H RG166 H H LA900 CD3 RG55 CD3 H H H LA2140 H H H RG167 H H LA901 CD3 RG56 CD3 H H H LA2141 H H H RG168 H H LA902 CD3 RG57 CD3 H H H LA2142 H H H RG169 H H LA903 CD3 RG58 CD3 H H H LA2143 H H H H RG1 H LA904 CD3 RG59 CD3 H H H LA2144 H H H H RG2 H LA905 CD3 RG60 CD3 H H H LA2145 H H H H RG3 H LA906 CD3 RG61 CD3 H H H LA2146 H H H H RG4 H LA907 CD3 RG62 CD3 H H H LA2147 H H H H RG5 H LA908 CD3 RG63 CD3 H H H LA2148 H H H H RG6 H LA909 CD3 RG64 CD3 H H H LA2149 H H H H RG7 H LA910 CD3 RG65 CD3 H H H LA2150 H H H H RG8 H LA911 CD3 RG66 CD3 H H H LA2151 H H H H RG9 H LA912 CD3 RG67 CD3 H H H LA2152 H H H H RG10 H LA913 CD3 RG68 CD3 H H H LA2153 H H H H RG11 H LA914 CD3 RG69 CD3 H H H LA2154 H H H H RG12 H LA915 CD3 RG70 CD3 H H H LA2155 H H H H RG13 H LA916 CD3 RG71 CD3 H H H LA2156 H H H H RG14 H

Ligand RA1 RA2 RA3 RA4 RA5 RA6 Ligand RA1 RA2 RA3 RA4 RA5 RA6 LA917 CD3 RG72 CD3 H H H LA2157 H H H H RG15 H LA918 CD3 RG73 CD3 H H H LA2158 H H H H RG16 H LA919 CD3 RG74 CD3 H H H LA2159 H H H H RG17 H LA920 CD3 RG75 CD3 H H H LA2160 H H H H RG18 H LA921 CD3 RG76 CD3 H H H LA2161 H H H H RG19 H LA922 CD3 RG77 CD3 H H H LA2162 H H H H RG20 H LA923 CD3 RG78 CD3 H H H LA2163 H H H H RG21 H LA924 CD3 RG79 CD3 H H H LA2164 H H H H RG22 H LA925 CD3 RG80 CD3 H H H LA2165 H H H H RG23