Glutaryl 7-ACA derivatives and processes for obtaining them

- Antibioticos S.p.A.

There are disclosed new compounds of formula (I), wherein R is: a hydrogen atom: a linear or branched C1-C4 alkyl group, unsubstituted or substituted by at least a phenyl group or at least a hydrogen atom: a benzyl group substituted by at least a linear or branched C1-C4 alkyl or alkoxy group or a nitro group; a silyl substituted by at least a linear or branched, unsubstituted or substituted C1-C4 alkyl group; n is 0 or 1; and Y is a radical of formula (II), wherein A is H, OH, Cl, CH2, CH2X, where X is F, Cl, Br, I, OH or OR' and R' is COCH3 or a linear or branched, unsubstituted or substituted C1-C4 alkyl group and . . . represents a single or a double bond, with the proviso that when n=0 and R is H, R' is not a methyl group; and processes for obtaining them.

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1. The compound of formula: ##STR9##

2. The compound of formula: ##STR10##

3. The compound of formula: ##STR11##

4. The compound of formula: ##STR12##

5. The compound of formula: ##STR13##

Referenced Cited
U.S. Patent Documents
3658649 April 1972 Arnold et al.
4275062 June 23, 1981 Breuer et al.
4558123 December 10, 1985 McShane
5095107 March 10, 1992 Blanchard
5229509 July 20, 1993 Nieves Elvira et al.
5424196 June 13, 1995 Cambiaghi et al.
5571910 November 5, 1996 Walker et al.
Other references
  • Matsumoto, K. et al Chemical Abstract No. 88:119418, The Abstract of JP 52125696 (Oct. 21, 1977), Obtained Via STN (1978). Carey, F. A. et al. Advanced Organic Chemistry, Part A: Structure and Mechanisms (Plenum Press, N.Y.) pp. 258, 259 and 286 (1990). Greene, T.W. Protective Groups in Organic Synthesis(Wiley & Sons, N.Y.) pp. 152-157 173 and 174 (1981). Greene, T.W. et al. Protective Groups in Organic Synthesis (Wiley & Sons, N.Y.) pp. 224-226, 253 and 254 (1991). Krempova, A. et al. Chemical Abstract No. 111:170083, The Abstract of CS 251457 (Aug. 15, 1988) Obtained Via STN (1989).
Patent History
Patent number: 5750682
Type: Grant
Filed: Mar 13, 1996
Date of Patent: May 12, 1998
Assignee: Antibioticos S.p.A. (Milan)
Inventors: Loris Sogli (Novara), Davide Longoni (Gorgonzola), Giovanni Pozzi (Besana Brianza), Enrico Siviero (Pavia), Daniele Mario Terrassan (Concorezzo), Ermanno Bernasconi (Caronno Varesino), Francisco Salto (Madrid)
Primary Examiner: Mukund J. Shah
Assistant Examiner: King Lit Wong
Law Firm: Oblon, Spivak, McClelland, Maier & Neustadt, P.C.
Application Number: 8/605,135