Glutaryl 7-ACA derivatives and processes for obtaining them
There are disclosed new compounds of formula (I), wherein R is: a hydrogen atom: a linear or branched C1-C4 alkyl group, unsubstituted or substituted by at least a phenyl group or at least a hydrogen atom: a benzyl group substituted by at least a linear or branched C1-C4 alkyl or alkoxy group or a nitro group; a silyl substituted by at least a linear or branched, unsubstituted or substituted C1-C4 alkyl group; n is 0 or 1; and Y is a radical of formula (II), wherein A is H, OH, Cl, CH2, CH2X, where X is F, Cl, Br, I, OH or OR' and R' is COCH3 or a linear or branched, unsubstituted or substituted C1-C4 alkyl group and . . . represents a single or a double bond, with the proviso that when n=0 and R is H, R' is not a methyl group; and processes for obtaining them.
Latest Antibioticos S.p.A. Patents:
- Process for the production of daptomycin
- Crystalline irinotecan hydrochloride and methods for its preparation
- CRYSTALLINE IRINOTECAN HYDROCHLORIDE AND METHODS FOR ITS PREPARATION
- PROCESS FOR THE PRODUCTION OF DAPTOMYCIN
- Crystalline Polymorphs of Topotecan Hydrochloride and Methods for the Preparation Thereof
Claims
1. The compound of formula: ##STR9##
2. The compound of formula: ##STR10##
3. The compound of formula: ##STR11##
4. The compound of formula: ##STR12##
5. The compound of formula: ##STR13##
3658649 | April 1972 | Arnold et al. |
4275062 | June 23, 1981 | Breuer et al. |
4558123 | December 10, 1985 | McShane |
5095107 | March 10, 1992 | Blanchard |
5229509 | July 20, 1993 | Nieves Elvira et al. |
5424196 | June 13, 1995 | Cambiaghi et al. |
5571910 | November 5, 1996 | Walker et al. |
- Matsumoto, K. et al Chemical Abstract No. 88:119418, The Abstract of JP 52125696 (Oct. 21, 1977), Obtained Via STN (1978). Carey, F. A. et al. Advanced Organic Chemistry, Part A: Structure and Mechanisms (Plenum Press, N.Y.) pp. 258, 259 and 286 (1990). Greene, T.W. Protective Groups in Organic Synthesis(Wiley & Sons, N.Y.) pp. 152-157 173 and 174 (1981). Greene, T.W. et al. Protective Groups in Organic Synthesis (Wiley & Sons, N.Y.) pp. 224-226, 253 and 254 (1991). Krempova, A. et al. Chemical Abstract No. 111:170083, The Abstract of CS 251457 (Aug. 15, 1988) Obtained Via STN (1989).
Type: Grant
Filed: Mar 13, 1996
Date of Patent: May 12, 1998
Assignee: Antibioticos S.p.A. (Milan)
Inventors: Loris Sogli (Novara), Davide Longoni (Gorgonzola), Giovanni Pozzi (Besana Brianza), Enrico Siviero (Pavia), Daniele Mario Terrassan (Concorezzo), Ermanno Bernasconi (Caronno Varesino), Francisco Salto (Madrid)
Primary Examiner: Mukund J. Shah
Assistant Examiner: King Lit Wong
Law Firm: Oblon, Spivak, McClelland, Maier & Neustadt, P.C.
Application Number: 8/605,135
International Classification: C07D50160;