Treatment of autoimmune disorders with oral interferon

Abstract

Autoimmune disorders are treated by the administration of human interferon, particularly IFN-.alpha. or IFN-.beta., at a dosage of from about 0.01 to about 5 IU/lb./day such that the interferon is held in contact with the patient's oral and pharyngeal mucosae. The interferon is administered in a solid dosage form, e.g., a saliva-dissolvable lozenge.

Claims

1. A method for treating a human patient afflicted with an autoimmune disorder characterized by chronic inflammatory tissue degeneration, the method consisting essentially of the steps of:

introducing a saliva-soluble dosage form of interferon into the mouth of the patient,

allowing the solid dosage form to dissolve in the mouth to form an interferon-containing solution, and

contacting the interferon-containing solution with the oral and pharyngeal mucosa;

2. The method of claim 1 wherein the administered interferon is human alpha-interferon.

3. The method of claim 2 wherein the interferon is administered at a dosage of about 0.1 to about 4.0 IU/lb of patient body weight per day.

4. The method of claim 1 wherein the autoimmune disorder is selected from the group consisting of multiple sclerosis, rheumatoid arthritis, nasal solar dermatitis, and lupus erythematosus.

5. The method of claim 1 wherein human alpha-interferon is administered to the human patient at a dosage of about 0.5 to about 1.5 IU/lb of patient body weight per day.

6. The method of claim 1 wherein the administered interferon is human beta-interferon.

7. The method of claim 1 wherein the solid dosage form is a lozenge.

8. The method of claim 2 wherein the solid dosage form is a lozenge.

9. The method of claim 3 wherein the solid dosage form is a lozenge.

10. The method of claim 4 wherein the solid dosage form is a lozenge.

11. The method of claim 5 wherein the solid dosage form is a lozenge.

12. The method of claim 6 wherein the solid dosage form is a lozenge.

13. A method for treating a human patient afflicted with an autoimmune disorder characterized by chronic inflammatory tissue degeneration, the method comprising the steps of:

introducing a saliva-soluble dosage form of interferon into the mouth of the patient,

allowing the solid dosage form to dissolve in the mouth to form an interferon-containing solution, and

contacting the interferon-containing solution with the oral and pharyngeal mucosa;

14. The method of claim 13 wherein the interferon is administered at a dosage of about 0.1 to about 4.0 IU/lb of patient body weight per day.

15. The method of claim 13 wherein the autoimmune disorder is selected from the group consisting of multiple sclerosis, rheumatoid arthritis, nasal solar dermatitis, and lupus erythematosus.

16. The method of claim 13 wherein human alpha-interferon is administered to the human patient at a dosage of about 0.5 to about 1.5 IU/lb of patient body weight per day.

17. The method of claim 13 wherein the administered interferon is human alpha-interferon.

18. The method of claim 17 wherein the saliva soluble dosage form is a lozenge.