Tablets, Lozenges, Or Pills Patents (Class 424/464)
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Patent number: 12128140Abstract: The disclosure provides an oral extended release formulation for the treatment of treatment-resistant depression and treatment-resistant anxiety.Type: GrantFiled: March 5, 2020Date of Patent: October 29, 2024Assignee: Douglas Pharmaceuticals, Ltd.Inventors: Paul William Glue, Natalie June Medlicott, Peter William Surman
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Patent number: 12109270Abstract: There is provided a complex comprising rifaximin and a complexing agent, wherein the complexing agent is a polyvinyl pyrrolidone (PVP) or a cyclodextrin. There is also provided a process for preparing the complex, a pharmaceutical composition including the complex and therapeutic uses of the complex.Type: GrantFiled: July 12, 2022Date of Patent: October 8, 2024Assignee: CIPLA LIMITEDInventors: Maruti Ganpati Ghagare, Sunilkumar Parasnath Saroj, Dharmaraj Ramachandra Rao, Rajendra Narayanrao Kankan
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Patent number: 12048672Abstract: Provided is packaged medicine capable of inhibiting deterioration of electrodes over a long period of time and reliably transmitting a signal after ingestion even when a long period of time has elapsed since production to ingestion. The packaged medicine includes a solid medicine including drug powder and a micro-device, a container provided with a solid medicine accommodating space accommodating the solid medicine therein, and inert gas encapsulated in the solid medicine accommodating space. The micro-device includes two electrodes with mutually different ionization tendencies and a transmitter operable to transmit a signal using electromotive force generated when the electrodes come in contact with electrolyte.Type: GrantFiled: May 1, 2018Date of Patent: July 30, 2024Assignee: Otsuka Pharmaceutical Co., Ltd.Inventors: Kazuma Yokoi, Kenzo Kashihara, Kenta Yamamoto, Takahiro Sonoki, Shohei Yamada
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Patent number: 11998029Abstract: The invention relates to a method for treating insects, comprising the separation of the cuticles from the soft part of the insects, followed by the separation of the soft part of the insects into an oil fraction, a solid fraction and an aqueous fraction. The invention further relates to powders, in particular a powder obtainable by the method of treating insects according to the invention, and to the use of these powders in food.Type: GrantFiled: March 10, 2017Date of Patent: June 4, 2024Inventors: Sophie Laurent, Thibault Sarton Du Jonchay, Jean-Gabriel Levon, Ceclia Socolsky, Lorena Sanchez, Nathalie Berezina, Benjamin Armenjon, Antoine Hubert
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Patent number: 11993561Abstract: The present disclosure discloses an expectorant compound, and specifically discloses compounds represented by formula I and formula II, pharmaceutically acceptable salts or tautomers thereof.Type: GrantFiled: July 1, 2020Date of Patent: May 28, 2024Assignee: HC SYNTHETIC PHARMACEUTICAL CO., LTD.Inventors: Cheng Yang, Sumin Qi, Qiyuan Zhang, Dongxing Li, Tieshan Chen, Xiaodan Zhao
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Patent number: 11980610Abstract: Disclosed are an oral solid dosage form composition comprising an active ingredient and a solubilizing carrier wherein a foaming ingredient is used to improve disintegration, dispersion or dissolution, and a preparation method therefor.Type: GrantFiled: October 30, 2018Date of Patent: May 14, 2024Assignee: SAMYANG HOLDINGS CORPORATIONInventors: Sang Yeob Park, Hye Jung Lim, Jae Young Lee, Min Hyo Seo, Sa Won Lee
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Patent number: 11980622Abstract: The present invention relates to extended release pharmaceutical dosage forms of oxcarbazepine.Type: GrantFiled: March 16, 2022Date of Patent: May 14, 2024Assignee: Apotex Inc.Inventors: Krishna Hari Bhandari, Sandeep Patel, Navin Vaya, Bernard Charles Sherman, Arunprasath Kaliaperumal
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Patent number: 11975077Abstract: A cell-penetrating peptide (CPP) comprising a plurality of mono(amino acid)s, oligo(amino acid)s, or poly(amino acid)s where a plurality of the amino acids comprise a positively charged guanylurea unit with a small molecule fragment and each of the mono(amino acid)s, oligo(amino acid)s, or poly(amino acid)s comprising a drug attached through a linker. The CPP can be used for treating cancers.Type: GrantFiled: September 17, 2021Date of Patent: May 7, 2024Assignee: THE FLORIDA INTERNATIONAL UNIVERSITY BOARD OF TRUSTEESInventor: Joong Ho Moon
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Patent number: 11951111Abstract: Described herein, in part, are tablets, such as immediate release multi-layer or bilayer tablets for orally delivering olanzapine and samidorphan, methods of using said tablets in the treatment of disorders described herein, and kits comprising said tablets.Type: GrantFiled: June 1, 2023Date of Patent: April 9, 2024Assignee: Alkermes Pharma Ireland LimitedInventors: Renato A. Chiarella, Hector Guzman, Paul Hurley, David Manser, Kristopher Perkin
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Patent number: 11925628Abstract: This invention discloses uses for nicardipine in preparing anti-lung cancer products. This invention provides uses for nicardipine in the preparation of products to treat non-small cell lung cancer. From carrying out cancer drug repositioning for the FDA- and CFDA-approved drug nicardipine, experiments for this invention show, based on screening of non-anti-cancer drugs for various cancer cell lines (tissue types) and mutation sites, that nicardipine has a new use as an anti-small cell lung cancer and/or anti-non small cell lung cancer medication, thus achieving a new purpose for an old drug.Type: GrantFiled: June 30, 2015Date of Patent: March 12, 2024Assignee: Shanghai Jiao Tong UniversityInventors: Yongyong Shi, Zhijian Song
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Patent number: 11918559Abstract: Oral dosage forms of metaxalone having improved bioavailability in the fed and fasted states, including dosage forms that employ a reduced dose based on such improved bioavailability.Type: GrantFiled: May 14, 2023Date of Patent: March 5, 2024Assignee: Primus Pharmceuticals, Inc.Inventors: Mukteeshwar Gande, Robert M. Levy
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Patent number: 11896732Abstract: The present invention is directed to a hemostatic material comprising a compacted, hemostatic aggregates of cellulosic fibers. In some aspects, the hemostatic material further includes additives, such as carboxymethyl cellulose (CMC) or other polysaccharides, calcium salts, anti-infective agents, hemostasis promoting agents, gelatin, collagen, or combinations thereof. In another aspect, the present invention is directed to a method of making the hemostatic materials described above by compacting a cellulosic-based material into hemostatic aggregates. In another aspect, the present invention is directed to a method of treating a wound by applying hemostatic materials described above onto and/or into the wound of a patient.Type: GrantFiled: December 22, 2021Date of Patent: February 13, 2024Assignee: Cilag GmbH InternationalInventor: Yi-Lan Wang
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Patent number: 11890267Abstract: A modified release benzonatate solid tablet or capsule is described which comprises a benzonatate adsorbate in a matrix with a sufficient amount of one or more pharmaceutically acceptable modified release pH-independent, substances to provide a modified release profile to the benzonatate, wherein there is substantially no benzonatate release from the tablet or capsule in the buccal cavity and no more than about 25% release of the benzonatate within 1 hour as determined in an in vitro dissolution assay.Type: GrantFiled: January 11, 2022Date of Patent: February 6, 2024Assignee: TRIS PHARMA INCInventors: Andrea Nelson, Quin-Zene Chen, Harsh Mehta, Yu-Hsing Tu
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Patent number: 11885817Abstract: Epileptic seizures are difficult to diagnose and are often difficult to distinguish from several conditions with similar presentations, and therefore, diagnosis of seizures is often a long, expensive, and unreliable process. This invention provides biomarkers for identifying seizures and epilepsy, assays for measuring and assessing biomarker concentration, predictive models based on biomarkers and computational systems for detecting, assessing and diagnosing phasic and tonic changes associated with seizures and epilepsy in all clinical and healthcare settings. Diagnostic and treatment methods, systems, kits, and predictive models provided herein, provide quantitative and/or qualitative assessment in order to allow patients to proceed immediately to diagnostic and/or treatment protocols, and assess therapeutic treatment effectiveness.Type: GrantFiled: May 16, 2018Date of Patent: January 30, 2024Assignee: Cognizance Biomarkers, LLCInventors: Todd Wallach, Elisa A. Waxman, John Gledhill, Richard St. Clair, Elizabeth Brand
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Patent number: 11883427Abstract: The disclosure provides for pharmaceutical compositions comprising an alginate salt, such as sodium alginate. The disclosure further provides for processes and methods for making pharmaceutical compositions. In yet a further aspect, the disclosure provides for methods of utilizing a pharmaceutical composition for treatment of acid reflux diseases. In another aspect, the disclosure provides for formulations suitable for oral use in dosage forms of capsules and dry powders.Type: GrantFiled: August 4, 2021Date of Patent: January 30, 2024Assignee: PHARAGEN LLCInventor: Joseph Ryan Smolarz
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Patent number: 11872318Abstract: Nanocrystals, compositions, and methods that aid particle transport in mucus are provided. In some embodiments, the compositions and methods involve making mucus-penetrating particles (MPP) without any polymeric carriers, or with minimal use of polymeric carriers. The compositions and methods may include, in some embodiments, modifying the surface coatings of particles formed of pharmaceutical agents that have a low water solubility. Such methods and compositions can be used to achieve efficient transport of particles of pharmaceutical agents though mucus barriers in the body for a wide spectrum of applications, including drug delivery, imaging, and diagnostic applications. In certain embodiments, a pharmaceutical composition including such particles is well-suited for administration routes involving the particles passing through a mucosal barrier.Type: GrantFiled: January 23, 2023Date of Patent: January 16, 2024Assignee: The Johns Hopkins UniversityInventors: Alexey Popov, Elizabeth M. Enlow, James Bourassa, Colin R. Gardner, Hongming Chen, Laura M. Ensign, Samuel K. Lai, Tao Yu, Justin Hanes, Ming Yang
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Patent number: 11857684Abstract: The present disclosure relates generally to bilayer tablets comprising a combination of two active pharmaceutical ingredients, and more specifically to bilayer tablets comprising acetylsalicylic acid, pseudoephedrine, and a dissolution aid. The bilayer tablets utilize a combination of granulated and non-granulated acetylsalicylic acid along with a unique distribution of sodium carbonate as a dissolution aid that provide acetylsalicylic acid and pseudoephedrine in a single dosage form having rapid dissolution and long-term storage stability (low degradation). The present disclosure also provides methods of preparing and of using the bilayer tablets.Type: GrantFiled: November 11, 2021Date of Patent: January 2, 2024Assignee: Bayer HealthCare LLCInventor: Harsh Mehta
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Patent number: 11857512Abstract: The present disclosure relates to pharmaceutical compositions, including dosage forms, such as tablets or capsules, comprising venglustat, in free base, or pharmaceutically acceptable salt form, a diluent/filler and a lubricant, optionally in combination with one or more additional therapeutic agents, to processes for manufacture thereof, and to methods of use in the treatment or prevention of disease.Type: GrantFiled: July 23, 2021Date of Patent: January 2, 2024Assignee: GENZYME CORPORATIONInventors: Audrey Jeanjean, Danielle Combessis, David Rigal, Chris Ho, Pankaj Taneja
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Patent number: 11857669Abstract: This disclosure features methods and compositions for treating diseases of the gastrointestinal tract with a JAK inhibitor.Type: GrantFiled: May 6, 2021Date of Patent: January 2, 2024Assignee: BIORA THERAPEUTICS, INC.Inventors: Mitchell Lawrence Jones, Sharat Singh, Christopher Loren Wahl, Harry Stylli
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Patent number: 11844822Abstract: The present invention relates to stabilization of a certain benzothia(dia)zepine derivative in a solid formulation containing the same. In the present invention, in a solid formulation containing the benzothia(dia)zepine derivative mentioned above, a combination of polyethylene glycol and polyvinyl alcohol is not blended, or alternatively, in the case of blending polyethylene glycol and polyvinyl alcohol in the solid formulation, the aforementioned derivative is isolated from the combination of polyethylene glycol and polyvinyl alcohol.Type: GrantFiled: June 15, 2020Date of Patent: December 19, 2023Assignee: Elobix ABInventors: Takahiko Ando, Hirokazu Hagio, Takashi Matsushita, Yusuke Ito
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Patent number: 11844866Abstract: A novel orally administrable dosage form including a drug/active layer for loading a therapeutic agent and an extension layer for retaining the API or drug dosage form in the stomach of a subject in need thereof. Also disclosed is a method of treating diseases with the dosage form.Type: GrantFiled: March 2, 2023Date of Patent: December 19, 2023Assignee: NOVELSTAR PHARMACEUTICALS, INC.Inventors: Fang Zhou, Shao Fu
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Patent number: 11840515Abstract: Disclosed herein are methods for obtaining N-(4-fluorobenzyl)-N-(1-methylpiperidin-4-yl)-N-(4-(2-methylpropyloxy)phenylmethyl) carbamide (pimavanserin) comprising the step of contacting an intermediate according to Formula (A) or a salt thereof, with an intermediate Formula B, or a salt thereof, to produce pimavanserin or a salt thereof wherein Y is —ORi or —NR2aR2b; R3 is hydrogen or substituted or unsubstituted heteroalicyclyl, R4 is substituted or unsubstituted aralkyl; X is —OR22 or —NR23R24; (wherein R22 is hydrogen or substituted or unsubstituted C1-6alkyl and one of R23 and R24 is hydrogen and the other is hydrogen or N-methylpiperidin-4-yl); and R21 is —OCH2CH(CH3)2 or F; Also disclosed herein is the tartrate salt of N-(4-fluorobenzyl)-N-(1-methylpiperidin-4-yl)-N?-(4-(2-methylpropyloxy)phenylmethyl) carbamide and methods for obtaining the salt.Type: GrantFiled: March 16, 2021Date of Patent: December 12, 2023Assignee: ACADIA Pharmaceuticals Inc.Inventors: Marlon Carlos, Sagun Tandel, Roger Olsson, Mikael Hillgren, Matthew J. Fleming, Andreas Philipp Boudier, Beat T. Weber
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Patent number: 11806421Abstract: The porous-cellulose particles according to the present invention are constituted by gathered crystalline celluloses having a type I crystal form including a glucose molecule as a constitutional unit. That is, porous-cellulose particles having high sphericity have been achieved from a natural raw material. The porous-cellulose particles have an average particle diameter of 0.5 to less than 50 ?m, a specific surface area of 50 to 1000 m2/g, and a sphericity of 0.85 or more. Cosmetic products containing such porous-cellulose particles have excellent texture properties.Type: GrantFiled: June 28, 2019Date of Patent: November 7, 2023Assignee: JGC CATALYSTS AND CHEMICALS LTD.Inventors: Satoshi Watanabe, Naoyuki Enomoto, Ikuko Shimazaki
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Patent number: 11801303Abstract: Preparations and formulations capable of crossing and incorporating into a membrane of a cell or an organelle or an exosome are described. Methods of treatments utilizing the preparations and formulations are also described.Type: GrantFiled: September 7, 2021Date of Patent: October 31, 2023Inventor: Joyce H. Ma
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Patent number: 11801671Abstract: This present invention relates to a method for making a two-layered product (3) comprising a hydrophilic first material (1) made from electrospun fibers connected to a hydrophobic second material (2) made from electrospun fibers, and wherein said first material (1) contains a drug substance, characterized in that —said method comprises using a press (5) comprising a first surface (100) and a second surface (200), and wherein said second surface (200) has a temperature being higher than the temperature of said first surface (100), —said first (1) and second material (2) being arranged in a layered combination between the first (100) and second surface (200) of the press (5), wherein a pressure is provided towards said layered combination from said first (100) and second surface (200) of said press (5), and whereby said first material (1) comes into contact with said first surface (100) of said press (5), —wherein the combination of pressure between the first (100) and second surface (200) and the temperature oType: GrantFiled: January 22, 2018Date of Patent: October 31, 2023Assignee: AFYX THERAPEUTICS A/SInventor: Jens Hansen
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Patent number: 11779595Abstract: Provided herein are methods and compositions for modulating a microorganism's response to an antimicrobial agent. In one embodiment, the method comprises contacting the microorganism with an antimicrobial agent and bicarbonate. In one embodiment, provided herein are methods for treating a microbial infection comprising administering to a subject in need an effective amount of (i) bicarbonate and (ii) an antimicrobial agent. Also provided herein are methods of screening for antimicrobial compounds.Type: GrantFiled: January 25, 2021Date of Patent: October 10, 2023Assignee: McMaster UniversityInventors: Eric Brown, Maya Farha, Craig MacNair, Jonathan Stokes
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Patent number: 11752095Abstract: The disclosure is directed to medroxyprogesterone compositions suitable for subcutaneous injection comprising about 260 mg/ml to 440 mg/ml medroxyprogesterone acetate, about 0.6 mg/ml to 1.5 mg/ml docusate sodium and, polyethylene glycol. Methods of using these compositions are also described.Type: GrantFiled: September 6, 2019Date of Patent: September 12, 2023Assignee: Family Health InternationalInventors: Prakash Sundaramurthi, Ivana Mijakovac, Andrea Rasic, Iva Tunjic
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Patent number: 11744827Abstract: Methods and compositions for treating a lysosomal movement associated disease in an animal, in which the position of lysosomes can influence disease progression, comprising administering an effective amount of a first lysosome migration inhibitor or a pharmaceutically acceptable salt, solvate, clathrate, stereoisomer, enantiomer or prodrug thereof.Type: GrantFiled: June 29, 2020Date of Patent: September 5, 2023Assignee: Board of Supervisors of Louisiana State University and Agricultural and Mechanical CollegeInventors: James Allen Cardelli, Magdalena Liliana Circu, Samantha Sarah Dykes, Hazem Edmond El-Osta
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Patent number: 11672761Abstract: A composition and method of treatment in a subject, whereby the subject is administered via the oral mucosa a rapidly infusing composition that includes (a) a pharmaceutically acceptable binder and/or excipient system containing gelatin and mannitol, and (b) a therapeutically effective amount of an active therapeutic ingredient (ATI). Preferably, a composition and method of treating pain in a subject, whereby the subject is administered via the oral mucosa a rapidly infusing composition that includes (a) a pharmaceutically acceptable binder and/or excipient system containing gelatin and mannitol, and (b) a therapeutically effective amount cannabidiol (CBD).Type: GrantFiled: April 8, 2021Date of Patent: June 13, 2023Assignee: Orcosa Inc.Inventors: Vincent T Mileto, Simon Winslow, Mark Ridall
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Patent number: 11642381Abstract: Microbiota restoration therapy (MRT) compositions (e.g., oral MRT compositions) and methods for manufacturing MRT compositions are disclosed. An example method for manufacturing an MRT composition may include collecting a stool sample, purifying the stool sample to form a purified sample, stabilizing the purified sample to form a stabilized sample, converting the stabilized sample to a solid, adding one or more additives and/or excipients to the solid to form a treatment composition, and encapsulating the treatment composition.Type: GrantFiled: November 9, 2020Date of Patent: May 9, 2023Assignee: REBIOTIX, INC.Inventors: Lee A. Jones, Courtney R. Jones, Beth Anne-Szkudlarek Brown, Joshua Erickson, Messac Che Neba
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Patent number: 11638690Abstract: Embodiments of the invention provide swallowable devices, preparations and methods for delivering drugs and other therapeutic agents within the GI tract. Many embodiments provide a swallowable device for delivering the agents. Particular embodiments provide a swallowable device such as a capsule for delivering drugs into the intestinal wall or other GI lumen. Embodiments also provide various drug preparations that are configured to be contained within the capsule, advanced from the capsule into the intestinal wall and degrade to release the drug into the bloodstream to produce a therapeutic effect. The preparation can be operably coupled to delivery means having a first configuration where the preparation is contained in the capsule and a second configuration where the preparation is advanced out of the capsule into the intestinal wall. Embodiments of the invention are particularly useful for the delivery of drugs which are poorly absorbed, tolerated and/or degraded within the GI tract.Type: GrantFiled: December 4, 2020Date of Patent: May 2, 2023Assignee: Rani Therapeutics, LLCInventor: Mir Imran
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Patent number: 11633389Abstract: An oral methylphenidate extended release tablet is described, which can be scored and still retain its extended release profile. The tablet contains a combination of an uncoated methylphenidate-ion exchange resin complex, a barrier coated methylphenidate-ion exchange resin complex-matrix, and an uncomplexed methylphenidate active component. Following administration of a single dose of the extended release methylphenidate chewable tablet, a therapeutically effective amount of methylphenidate is reached in less than about 20 minutes and the composition provides a twelve-hour extended release profile.Type: GrantFiled: October 14, 2020Date of Patent: April 25, 2023Assignee: TRIS PHARMA, INCInventors: Yu-Hsing Tu, Ashok Perumal, Kalyan Kathala
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Patent number: 11633361Abstract: A product and process of manufacturing an edible soft-chewable dosage form for the delivery of pharmaceutically active ingredients or nutritional agents orally to an animal or human subject, by forming a granulated soft-chew mass by appropriate mixing and sifting steps, and forming tablets with a compression press. Such soft-chew dosage forms have hardness of less than about two kilopond (2 kp) and friability of less than about one percent (1%) at three-hundred (300) rotations when measured according to the United States Pharmacopeia (USP) test. The process for manufacturing such compressed soft-chew tablets employs compression (tablet) pressing equipment to produce soft-chew tablets of consistent weight and texture.Type: GrantFiled: June 5, 2020Date of Patent: April 25, 2023Assignee: First Time US Generics LLCInventors: Manesh A. Dixit, Vaibhav L. Pawar, Rushi R. Patel, Mineshkumar D. Patel, Amol Somwanshi
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Patent number: 11617721Abstract: The present disclosure relates to a dry process for preparing a solid pharmaceutical dosage form of vitamin K1 comprising: a) blending vitamin K1 with a first diluent under a first set of pre-determined conditions to obtain a first mixture; b) contacting the first mixture with a second diluent under a second set of pre-determined conditions to obtain a second mixture; c) mixing the second mixture with the excipients selected from a group consisting of disintegrant, lubricant and glidant under a third set of pre-determined conditions to obtain a third mixture; and d) compressing or encapsulating the third mixture to obtain the solid pharmaceutical dosage form of vitamin K1.Type: GrantFiled: December 20, 2019Date of Patent: April 4, 2023Assignee: ATOZ PHARMACEUTICALS LTD.Inventors: Olaganathan Arumugam, Natarajan Venkatachalam
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Patent number: 11596670Abstract: This disclosure features methods and compositions for treating diseases of the gastrointestinal tract with IL-10 or an IL-10 agonist.Type: GrantFiled: March 30, 2018Date of Patent: March 7, 2023Assignee: BIORA THERAPEUTICS, INC.Inventors: Mitchell Lawrence Jones, Sharat Singh, Christopher Loren Wahl, Harry Stylli
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Patent number: 11590100Abstract: A thermogenic cannabis composition for oral administration, including cannabis extract and at least one thermogenic agent, and method of producing same.Type: GrantFiled: April 20, 2021Date of Patent: February 28, 2023Assignee: PANAXIA PHARMACEUTICAL INDUSTRIES LTD.Inventors: David Segal, Eran Goldberg, Shany Hershkovits, Hagai Moshe
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Patent number: 11576941Abstract: The invention discloses taste masking formulations for bitter natural compounds, selected from the extracts, fraction and pure phytochemicals produced in combination with a synthetic polymer or a natural polymer. The invention also relates to the novel process of producing the taste masking formulations. The invention also relates to taste masking formulations of Bacopa extracts with no bitter taste or negligible bitter taste in combination with synthetic polymers such as Eudragit or natural polymers such as Shellac.Type: GrantFiled: June 21, 2017Date of Patent: February 14, 2023Assignee: LAILA NUTRACEUTICALSInventors: Ganga Raju Gokaraju, Rama Raju Gokaraju, Kishore Babu Govada, Venkata Krishna Raju Alluri, Nagendra Babu Vutti, Kiran Bhupathiraju, Venkata Kanaka Ranga Raju Gokaraju, Trimurtulu Golakoti
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Patent number: 11576903Abstract: Provided herein is an amorphous compound represented by Formula (I): and compositions thereof, which are useful in the treatment of disorders related to the activity of the c-KIT and PDGFR? kinases, and oncogenic forms thereof.Type: GrantFiled: October 18, 2021Date of Patent: February 14, 2023Assignee: Deciphera Pharmaceuticals, LLCInventors: Michael D. Kaufman, Scott Bone, Corey Bloom, Fred Jordan
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Patent number: 11576867Abstract: A dosage form comprising a tablet core and one or more discontinuous coated regions in various configurations on the surface of the dosage form is disclosed. A method for making the dosage form is also disclosed.Type: GrantFiled: January 28, 2020Date of Patent: February 14, 2023Assignee: Johnson & Johnson Consumer Inc.Inventors: Harry Sowden, Gerard McNally, Der-Yang Lee
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Patent number: 11571151Abstract: Embodiments herein include implantable medical devices including chemical sensors with bioerodible masking layers to allow for staged activation of the sensors. In an embodiment, an implantable medical device includes a substrate defining wells and a first chemical sensor and a second chemical sensor disposed within separate wells of the substrate. The first chemical sensor and the second chemical sensor can be configured to detect one or more analytes. The device can include a first bioerodible masking layer disposed over the second chemical sensor, sealing off the second chemical sensor. The device can further include a protective planarization layer disposed over at least one of the first chemical sensor and the second chemical sensor such that the outermost surface of the medical device over the first sensor is flush with the outermost surface of the medical device over the second sensor. Other embodiments are also included herein.Type: GrantFiled: August 21, 2018Date of Patent: February 7, 2023Assignee: Cardiac Pacemakers, Inc.Inventors: Michael John Kane, Yingbo Li
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Patent number: 11559485Abstract: Amorphous solid dispersions and pharmaceutical compositions of the protein kinase inhibitor nilotinib. The pharmaceutical compositions may be used in methods of treating a proliferative disorder such as cancer. In particular, the present disclosure provides a pharmaceutical composition in the form of an orally disintegrating tablet. In some embodiments, the pharmaceutical compositions can be administered without regard to food consumption. In other embodiments, the pharmaceutical compositions can be administered at a significantly lower dose as compared to a commercially available immediate-release nilotinib formulation, while providing a comparable therapeutic effect.Type: GrantFiled: May 24, 2021Date of Patent: January 24, 2023Assignee: NANOCOPOEIA, LLCInventors: Christian F. Wertz, Tzehaw Chen, Joseph McTarsney, Sarah M. Rieschl, Limin Shi
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Patent number: 11530374Abstract: A laundry care composition comprises a laundry care ingredient or adjunct and at least one compound that is capable of changing from a first color state (i.e., the initial color state in the composition) to a second color state that is perceptibly different from the first color state. A method for treating textile articles comprises the steps of: (a) providing a laundry care composition as described above; (b) adding the laundry care composition to a liquid medium; and (c) placing the textile articles in the liquid medium.Type: GrantFiled: May 5, 2015Date of Patent: December 20, 2022Assignee: Milliken & CompanyInventors: Benjamin R. Butterfield, Eduardo Torres, Sanjeev K. Dey, Michael Hong, Haihu Qin, Dominick J. Valenti
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Patent number: 11510877Abstract: Multiparticulate compositions including an active agent and a gelling agent are disclosed. The multiparticulate compositions are prepared by an aqueous-based spray and congeal process.Type: GrantFiled: October 9, 2018Date of Patent: November 29, 2022Assignee: Capsugel Belgium NVInventors: Christopher D. Craig, Cody Prather
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Patent number: 11504333Abstract: The invention pertains to dispersible tablets comprising as active ingredient N-{3-[5-(2-Amino-4-pyrimidinyl)-2-(1,1-dimethylethyl)-1,3-thiazol-4-yl]-2-fluorophenyl}-2,6-difluorobenzenesulfonamide, methanesulfonate salt, processes for preparing the same, and processes for using the same.Type: GrantFiled: June 29, 2018Date of Patent: November 22, 2022Assignee: Novartis AGInventors: Nikos Karanikolopoulos, Paul Anthony Goulding
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Patent number: 11504332Abstract: Compositions and kits for oral administration of a phosphodiesterase-4 (PDE4) inhibitor and one or more additional active agents that reduces or eliminates a side effect associated with the PDE4 inhibitor are provided. Also provided are methods for use of these compositions and kits for treating conditions treatable with a PDE4 inhibitor therapy and for increasing patient compliance with treatment with PDE4 inhibitors.Type: GrantFiled: August 16, 2021Date of Patent: November 22, 2022Assignee: VK RESEARCH ASSOCIATES INC.Inventors: Victor Chehebar, Siva Rama Krishna Nutalapati
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Patent number: 11478432Abstract: The present invention relates to the technical field of medicine and relates to an instant release pharmaceutical preparation of an anticoagulant and a preparation method therefor. The instant release pharmaceutical preparation of an anticoagulant comprises a vicagrel compound or a pharmaceutically acceptable form thereof, the preparation is a tablet or a capsule, the vicagrel or the pharmaceutically acceptable form thereof is provided at a suitable particle size, and the D90 thereof <50 ?m. With regard to the drug-containing particles obtained by the present invention, a pharmaceutical preparation formed therefrom exhibits rapid release characteristics in an in vitro dissolution test and exhibits considerable advantages in pharmacokinetics in vivo, showing a greater degree (AUC) and rate (Cmax) of drug absorption.Type: GrantFiled: April 16, 2018Date of Patent: October 25, 2022Assignee: Jiangsu Vcare Pharma Tech Co., Ltd.Inventors: Yanlei Zhao, Jianjun Zhang, Xuefang Liu, Yuan Gao, Hongbin Sun, Yanchun Gong, Yongqiang Liu
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Patent number: 11465107Abstract: The present invention relates to a process of producing a nano Omega-3 microemulsion system includes: (i) preparing a dispersal phase by heating Omega-3; (ii) preparing a carrier by heating a liquid PEG (polyethylene glycol); (iii) adding the carrier to the dispersal phase; (iv) emulsifying as follows: when the temperature arrives at 60° C., adding ACRYSOL K-140 to the mixture of the carrier and dispersal phase in step (iii), continuing to stir at a speed of 500 to 700 rpm, at a temperature of 60 to 80° C., in vacuum, for 3 to 5 hours, controlling the quality of resulting product by dissolving into water and measuring the transparency, the reaction is quenched, the temperature is decreased slowly until it is in the range of 40 to 60° C.; emulsifying for the entire mixture for 30 minutes; (v) filtrating the product by injecting through nanofilter system before filling-packaging.Type: GrantFiled: August 5, 2019Date of Patent: October 11, 2022Inventor: Hong Ngoc Thi Dang
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Patent number: 11452721Abstract: Provided herein are capsules containing pimavanserin, processes for manufacturing said capsule, and pharmaceutical compositions containing pimavanserin.Type: GrantFiled: March 14, 2022Date of Patent: September 27, 2022Assignee: ACADIA Pharmaceuticals Inc.Inventors: Ravindra Tejwani, Stephen Edward Abele, Emanuel Joseph Vizzotti
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Patent number: 11446248Abstract: A process for the preparation of oral delayed release solid formulations and the formulations obtainable from said process are now described. Said process comprises the following steps: a) melting at least one lipid; b) spraying said at least one melted lipid on at least one active ingredient in the form of a moving powder; c) cooling the resulting mixture; d) optional granulation of the mixture; e) optional compression of the mixture.Type: GrantFiled: December 21, 2018Date of Patent: September 20, 2022Inventor: Antonio Enrico Seneci
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Patent number: 11439599Abstract: The invention relates to a scored tablet (1) comprising a convex upper face (2), an at least partially concave lower face (3) and a side wall (4) extending between the upper and lower faces; two score grooves (5, 6) are formed in the concave lower face, said grooves being perpendicular to one another and continuous with score slits (8, 9, 10, 11) located in the side wall.Type: GrantFiled: May 22, 2018Date of Patent: September 13, 2022Assignee: CEVA SANTE ANIMALEInventors: Nadège Mallo, Philippe Jolivet, Mickael Venel, Rosita Garcia