Pharmaceutical composition for inhibiting the growth of cancers

Abstract

A pharmaceutical composition that inhibits the growth of tumors and cancers in mammals and can be used to treat viral infections that comprises a fungicide in combination with chemotherapeutic agents is disclosed. The particular fungicide used is a benzimidazole derivative. Potentiators can also be included in the composition.

Claims

1. A method of treating cancer susceptible to treatment in warm blooded mammals comprising administering a safe and effective amount of a pharmaceutical composition comprising a safe and enhanced amount of a benzimodale selected from the group consisting of: ##STR5## wherein X is hydrogen, halogen, alkyl of less than 7 carbon atoms or alkoxy of less than 7 carbon atoms; n is a positive integer of less than 4; Y is hydrogen, chlorine, nitro, methyl or ethyl; and R is hydrogen, CONHR.sub.3 wherein R.sub.3 is alkyl of less in 7 carbons or an alkyl group having from 1 to 8 carbon atoms, and R.sub.2 is 4thiazolyl or NHCOOR.sub.1 wherein R.sub.1 is an aliphatic hydrocarbon of less than 7 carbon atoms and the pharmaceutically acceptable organic or inorganic acid addition salts thereof, a safe and effective amount of a chemotherapeutic agent and a safe and effective amount of a potentiator.

2. A method according to claim 1 wherein said chemotherapeutic agent is selected from the group consisting of DNA-interactive Agents, Antimetabolites, Tubulin-Interactive Agents, Hormonal agents, Asparaginase or hydroxyurea.

3. A unit dosage composition for treating cancer susceptible to treatment in animals or humans comprising a safe and enhanced amount of a benzimidazole selected from the group consisting of ##STR6## wherein X is hydrogen, halogen, alkyl of less than 7 carbon atoms or alkoxy of less than 7 carbon atoms; n is a positive integer of less than 4; Y is hydrogen, chlorine, nitro, methyl or ethyl; and R is hydrogen, CONHR.sub.3 wherein R.sub.3 is alkyl of less than 7 carbons or an alkyl group having from 1 to 8 carbon atoms, and R.sub.2 is 4-thiazolyl or NHCOOR.sub.1 wherein R.sub.1 is aliphatic hydrocarbon of less than 7 carbon atoms and pharmaceutically acceptable salts thereof, a safe and effective amount of a chemotherapeutic agent and safe and effective amount of a potentiator.

4. A pharmaceutical composition for treating cancers, tumors or leukemia susceptible to treatment comprising a pharmaceutical carrier and a safe and enhanced amount of a benzimidazole selected from the group consisting of: ##STR7## wherein X is hydrogen, halogen, alkyl of less than 7 carbon atoms or alkoxy of less than 7 carbon atoms; n is a positive integer of less than 4; Y is hydrogen, chlorine, nitro, methyl or ethyl; and R is hydrogen CONHR.sub.3 wherein R.sub.3 is alkyl of less than 7 carbons or an alkyl group having from 1 to 8 carbon atoms, and R.sub.2 is 44thiazolyl or NHCOOR.sub.1 wherein R.sub.1 is aliphatic hydrocarbon of less than 7 carbon atoms, and the pharmaceutically acceptable inorganic or acid addition salts thereof; a safe and effective amount of a chemotherapeutic agent and a safe and effective amount of a potentiator.

5. A pharmaceutical composition for treating cancer susceptible to treatment in animals or humans comprising a safe and enhanced amount of a benzimidazole selected from the group consisting of: ##STR8## wherein X is hydrogen; Y is hydrogen and R is hydrogen and R.sub.2 is NHCOOR.sub.1 wherein R.sub.1 is an aliphatic hydrocarbon of less than 7 carbon atoms and the pharmaceutically acceptable organic or inorganic acid addition salts thereof; and a safe and effective amount of a chemotherapeutic agent and a safe and effective amount of a potentiator.