Aminomethanobenzazocine intermediates

N-Alkylated-8-aminated-2,6-methano-3-benzazocines, useful as strong analgesics, are prepared by one route comprising reduction of 8-nitro intermediates or by another route comprising Birch type reduction of 8-methoxy intermediates followed by dehydration-rearrangement of the oximes of the resulting 8-oxo intermediates.

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Claims

Referenced Cited
U.S. Patent Documents
3632591 January 1972 Albertson et al.
3764606 October 1973 Akkerman et al.
3853889 December 1974 Monkovic et al.
4009171 February 22, 1977 Albertson
Patent History
Patent number: RE29943
Type: Grant
Filed: Aug 22, 1977
Date of Patent: Mar 20, 1979
Assignee: Sterling Drug Inc. (New York, NY)
Inventors: Mark P. Wentland (North Greenbush, NY), Noel F. Albertson (Schodack, NY)
Primary Examiner: Natalie Trousof
Assistant Examiner: Richard A. Schwartz
Attorneys: Theodore C. Miller, B. Woodrow Wyatt
Application Number: 5/826,683
Classifications
Current U.S. Class: Two Of The Cyclos Share At Least Three Ring Carbons (e.g., Benzomorphans, Etc.) (546/97); 424/267
International Classification: C07D22126;