15-Deoxy-16-hydroxy-16-vinyl and cyclopropyl substituted prostanoic acids and congeners

Abstract

This disclosure describes esters having prostaglandin-like activity of 15-deoxy-16-hydroxy-16-substituted-prostanoic acids formed by replacing the hydroxy group of the C.sub.1 -carboxylic acid substituent with para-acetamidophenoxy, methylsulfonylamido, para-acetylphenoxy, para-phenylphenoxy, C.sub.3 -C.sub.10 cycloalkoxy, arylalkoxy wherein the alkoxy group has from 7-12 carbon atoms, phenoxy or phenoxy substituted with 1-3 chlorine atoms or C.sub.1 -C.sub.3 alkyl, phenacyloxy or phenacyloxy ring-substituted with from 1-3 bromine atoms, a nitro moiety, C.sub.1-C.sub.8 arylalkyl, or arylalkoxy wherein the alkoxy group has from 7-12 carbon atoms; substituted arylamino (C.sub.1 -C.sub.12), substituted-naphthoxy, fluorenoxy, carboxyalkoxy (C.sub.5 -C.sub.11), 5-indanyloxy, benzoylphenoxy, benzyloxy or ring-substituted benzyloxy, glyceryloxy, phosphatoglyceryloxy, amino substituted with an alkanoyl or cycloalkanoyl group; aroyl or substituted aroyl; alkylsulfonyl; arylsulfonyl or substituted-arylsulfonyl, hydrazinyl and substituted hydrazinyl; alkylamino (C.sub.1 -C.sub.5), or the semicarbazide of the para-formylphenoxy group.

Description