Unsubstituted Acids Of The Acetic Series Patents (Class 560/231)
  • Patent number: 9700499
    Abstract: Provided are personal care products and compositions that comprise at least one preservative compound selected from the group consisting of phenoxyethanol, 2-phenyl ethanol, phenoxypropanol, 3-phenylpropanol and benzylalcohol, in a total concentration of 0.1 to 1% (w/w); and at least one preservative enhancer compound selected from the group consisting of 4-methylbenzaldehyde, heliotropine, vanilline, 4-hydroxybenzaldehye, 3-hydroxybenzaldehyde, 4-methoxybenzaldehyde, 3-methoxybenzaldehyde, 2, 4-dihydroxybenzaldehyde, 3-hydroxy-4-methoxybenzaldehyde, 3, 5-dihydroxybenzaldehyde, and 4-hydroxy-2-methoxybenzaldehyde, in a total concentration of 0.05 to 0.5% (w/w), in a cosmetically acceptable base. The composition does not contain certain classic bactericidal, fungicidal, sporicidal or preservative compounds. Further provided are methods of forming such compositions and products and the use of preservatives and preservative enhancers in such compositions and products.
    Type: Grant
    Filed: December 18, 2006
    Date of Patent: July 11, 2017
    Assignee: GIVAUDAN SA
    Inventor: Andreas Natsch
  • Patent number: 9302974
    Abstract: A process for producing acetic acid is disclosed in which the water concentration is controlled in the side stream between two columns. Controlling the water concentration by a recycle rate of the light liquid phase maintains the hydrogen iodide concentration in the side stream to be up to 50 wppm.
    Type: Grant
    Filed: July 1, 2015
    Date of Patent: April 5, 2016
    Assignee: CELANESE INTERNATIONAL CORPORATION
    Inventors: Ronald D. Shaver, Yaw-Haw Liu, Mark O. Scates
  • Patent number: 9290718
    Abstract: The present invention pertains to novel cyclopentanols and their unexpected advantageous use thereof in enhancing, improving or modifying the fragrance of perfumes, colognes, toilet waters, fabric care products, personal products, and the like.
    Type: Grant
    Filed: December 11, 2013
    Date of Patent: March 22, 2016
    Assignee: International Flavors & Fragrances Inc.
    Inventors: Anthony T. Levorse, Jr., Nicole L. Giffin
  • Patent number: 9079851
    Abstract: A reactive distillation method comprises introducing an feed stream comprising ethanol to a reactive distillation column, contacting the feed stream with a catalyst in the reactive distillation column during a distillation, where the feed stream reacts in the presence of the catalyst to produce a reaction product comprising ethyl acetate and hydrogen, removing ethyl acetate during the distillation from the reactive distillation column as a bottoms stream, and removing hydrogen during the distillation from the reactive distillation column as an overhead stream.
    Type: Grant
    Filed: February 1, 2012
    Date of Patent: July 14, 2015
    Assignee: Greenyug, LLC
    Inventors: Sagar B. Gadewar, Brian Christopher Vicente, Robert Elliot Norton, Michael Francis Doherty
  • Publication number: 20150119599
    Abstract: This invention relates to a gem-dinitro ester energetic material represented by Chemical Formula 1 below, which is synthesized using esterification, and to a preparation method thereof: wherein R is a C5˜C15 substituted or unsubstituted linear or branched alkyl group.
    Type: Application
    Filed: May 29, 2014
    Publication date: April 30, 2015
    Applicant: AGENCY FOR DEFENSE DEVELOPMENT
    Inventors: Seung-Hee KIM, Jin-Seuk KIM
  • Publication number: 20150118165
    Abstract: The present invention relates to the use of at least one cyclohexanol ether derivative of the formula I as antimicrobial active compound or as anti-acne, antidandruff, deodorant or antiperspirant active compound, to preparations comprising these compounds, and to specific cyclohexanol ether derivatives.
    Type: Application
    Filed: April 5, 2013
    Publication date: April 30, 2015
    Applicant: Merck Patent GmbH
    Inventors: Thomas Rudolph, Sylvia Eisenberg
  • Patent number: 8987501
    Abstract: A radioisotope labeled reagent includes a compound having the general formula (I), L-(aCbH2)naCbH3??(I) where a in each occurrence independently is a carbon mass number between 11 and 14 inclusive, b in each occurrence independently is a hydrogen mass number between 1 and 3 inclusive, such that a in each occurrence is not 12 simultaneously with b in each occurrence being 1; L is a leaving group R1SO2—O—, R1—S—, 12C1H3(12C3H2)n—S—R1C(O)O—, NC—, (R1)3P—, XMg- and Li—, where n is an integer between 0 and 3 inclusive, where X is chloro, bromo or iodine, where R1 is H, aryl, a substituent containing aryl, C1-C20 alkyl, a substituent containing C1-C20 alkyl, C2-C20 alkenyl, a substitute containing C2-C20 alkenyl, C2-C20 alkynyl, and a substitute containing C2-C20 alkynyl with the proviso that when n is 0, a is 13 and b is 2 and R1 in R1—S is not aryl.
    Type: Grant
    Filed: October 4, 2012
    Date of Patent: March 24, 2015
    Assignee: PerkinElmer Health Sciences, Inc.
    Inventor: Jerry Scot Pounds
  • Patent number: 8969613
    Abstract: A system and method for removing acetaldehyde from an acetic acid system, including providing a solution from the acetic acid system, the stream having methyl iodide and acetaldehyde, and contacting the solution with an ion-exchange resin and/or liquid catalyst.
    Type: Grant
    Filed: October 31, 2012
    Date of Patent: March 3, 2015
    Assignee: LyondellBasell Acetyls, LLC
    Inventors: Noel C. Hallinan, Brian A. Salisbury
  • Publication number: 20150021194
    Abstract: Solution-phase (e.g., homogeneous) or surface-immobilized (e.g., heterogeneous) electrode-driven oxidation catalysts based on iridium coordination compounds which self-assemble upon chemical or electrochemical oxidation of suitable precursors and methods of making and using thereof are. Iridium species such as {[Ir(LX)x(H2O)y(?-O)]zm+}n wherein x, y, m are integers from 0-4, z and n from 1-4 and LX is an oxidation-resistant chelate ligand or ligands, such as such as 2(2-pyridyl)-2-propanolate, form upon oxidation of various molecular iridium complexes, for instance [Cp*Ir(LX)OH] or [(cod)Ir(LX)] (Cp*=pentamethylcyclopentadienyl, cod=cis-cis,1,5-cyclooctadiene) when exposed to oxidative conditions, such as sodium periodate (NaIO4) in aqueous solution at ambient conditions.
    Type: Application
    Filed: June 27, 2014
    Publication date: January 22, 2015
    Inventors: Stafford Wheeler Sheehan, Ulrich Hintermair, Julianne M. Thomsen, Gary W. Brudvig, Robert H. Crabtree
  • Publication number: 20150025266
    Abstract: In one embodiment, the present application discloses methods to selectively synthesize higher alcohols and hydrocarbons useful as fuels and industrial chemicals from syngas and biomass. Ketene and ketonization chemistry along with hydrogenation reactions are used to synthesize fuels and chemicals. In another embodiment, ketene used to form fuels and chemicals may be manufactured from acetic acid which in turn can be synthesized from synthesis gas which is produced from coal, biomass, natural gas, etc.
    Type: Application
    Filed: July 16, 2013
    Publication date: January 22, 2015
    Applicant: Pioneer Energy, Inc.
    Inventors: John Henri, Jan Zygmunt, Mark Berggren, Robert Zubrin
  • Publication number: 20150017227
    Abstract: Disclosed are methods and compositions for treating skin diseases or conditions with a composition containing a lipid component as an active ingredient.
    Type: Application
    Filed: July 11, 2014
    Publication date: January 15, 2015
    Inventors: Byung Eui Kim, Donald Y.M. Leung
  • Publication number: 20140336407
    Abstract: A process of integrated system formed by coupling of fixed bed, jetting floating bed, and separating unit, aimed to provide a new process and equipment of higher efficiency, which integrates multi-type reactors and separation is provided. Reaction materials undergo preliminary reaction in fixed bed reactor and intensified reaction in jetting floating bed reactor, and then separation in the subsequent separation system. Unreacted materials will be returned to the raw material intermediate storage tank for mixing with fresh materials, as raw materials for continued reaction. During this process, materials first pass the fixed bed reactor once to achieve certain conversion rate, and then enter the jetting floating bed reactor for intensified reaction. When the product reaches required concentration, the materials will enter subsequent separation equipment for separation.
    Type: Application
    Filed: May 25, 2012
    Publication date: November 13, 2014
    Inventors: Zheng Zhou, Zhibing Zhang, Gaodong Yang, Xionghui Gong, Pingkeng Wu
  • Publication number: 20140336137
    Abstract: The invention relates to nitroso derivatives including carboxylic acid and phosphoric acid esters of hydroxy nitroso compounds that donate nitroxyl (HNO) under physiological conditions. The compounds and compositions of the invention are useful in treating and/or preventing the onset and/or development of diseases or conditions that are responsive to nitroxyl therapy, including heart failure, ischemia/reperfusion injury and cancer.
    Type: Application
    Filed: July 28, 2014
    Publication date: November 13, 2014
    Inventors: Lisa Marie Frost, Stephen Martin Courtney, Frederick Arthur Brookfield, Vincent Jacob Kalish
  • Publication number: 20140323757
    Abstract: The present invention provides a novel compound isolated from yeasts and its use as a bio-surfactant. The bio-surfactant of the present invention shows high surfactant activity, is biodegradable, and is safe to the human body due to its low toxicity. Also, the bio-surfactant of the present invention can be eco-friendly produced through a cultivation of a microorganism in large quantities.
    Type: Application
    Filed: July 15, 2013
    Publication date: October 30, 2014
    Inventor: Jong Shik Kim
  • Publication number: 20140235891
    Abstract: The invention relates to an application of organic framework porous solid acid.
    Type: Application
    Filed: July 6, 2012
    Publication date: August 21, 2014
    Applicant: PetroChina Company Limited
    Inventors: Wenpeng Li, Fengshou Xiao, Haicheng Xiao, Fujian Liu, Yinghui Li, Xiangju Meng, Xianming Xu, Xiangmin Yu, Wei Zhang, Kezhong Xu, Guoquan Song, Haotian Pei, Fangwei Li, Qunying Zeng, Zhixiang Zhang, Yeman Li
  • Patent number: 8778838
    Abstract: The present invention relates to aqueous concentrate formulations for plant protection comprising: 2-chloro-5-[3,6-dihydro-3-methyl-2,6-dioxo-4-(trifluoromethyl)-1-(2H)pyrimidinyl]-4-fluoro-N-[[methyl(1-methylethyl)amino]sulfonyl]benzamide in the form of its anhydrate; N-(phosphonomethyl)glycine in the form of its free acid, in the form of the ammonium salt or a substituted ammonium salt or a mixture thereof; at least two different non-ionic surfactants with at least one of them comprising an ethylene oxide polymer moiety or an ethylene oxide/C3-C4-alkylene oxide block copolymer moiety, and water; wherein the pH-value of the formulation is below 6.
    Type: Grant
    Filed: August 26, 2010
    Date of Patent: July 15, 2014
    Assignee: BASF SE
    Inventors: Michael Krapp, Wolfgang Gregori, Sven Adam, Klaus Kolb, Juergen Jakob, Bernd Sievernich, Joerg Steuerwald, Steven Bowe, Joseph Zawierucha, Rex Liebl
  • Publication number: 20140194648
    Abstract: Process for producing 2-ethylheptanoic acid.
    Type: Application
    Filed: May 15, 2012
    Publication date: July 10, 2014
    Applicant: Evonik Degussa GmbH
    Inventors: Christian Boeing, Dietrich Maschmeyer, Markus Winterberg, Michael Grass, Andreas Gevers, Hinnerk Gordon Becker
  • Publication number: 20140187812
    Abstract: The invention provides systems and processes for concentrating acetic acid and acetic anhydride streams. The systems allow operation of equipment used for such concentrations in two or more modes of operation. At least one mode is intended to produce a concentrated or purified acetic acid stream. At least one other mode is intended to produce a concentrated or purified acetic anhydride stream.
    Type: Application
    Filed: March 14, 2013
    Publication date: July 3, 2014
    Applicant: Eastman Chemical Company
    Inventors: Gregory Abbott Wellman, JR., Joseph Nathaniel Bays, Robert Sterling Kline
  • Patent number: 8748673
    Abstract: Disclosed herein are processes for alcohol production by reducing an esterification product, such as ethyl acetate. The processes comprise esterifying acetic acid and an alcohol such as ethanol to produce an esterification product. The esterification product is reduced with hydrogen in the presence of a catalyst to obtain a crude reaction mixture comprising ethyl acetate, ethanol, and at least one alcohol having at least 4 carbon atoms. The ethanol is recovered with a reduced amount of the alcohol having at least 4 carbon atoms.
    Type: Grant
    Filed: November 18, 2011
    Date of Patent: June 10, 2014
    Assignee: Celanese International Corporation
    Inventors: R. Jay Warner, Wei Qi, Tatiana Sonnenberg
  • Patent number: 8703102
    Abstract: The present disclosure provides various methods and systems for manufacture, transport and delivery of material including highly polarized nuclei that is in a hyperpolarized state.
    Type: Grant
    Filed: September 10, 2010
    Date of Patent: April 22, 2014
    Assignee: Millikelvin Technologies LLC
    Inventors: Neal Kalechofsky, Avrum Belzer
  • Patent number: 8703994
    Abstract: A process for preparing carboxylic acid derivatives of the formula H—(C?O)—R, R is OR1 or NR2R3, R1 is optionally substituted C1-C15-alkyl, C5-C10-cycloalkyl, C5-C10-heterocyclyl, C5-C10-aryl or C5-C10-heteroaryl, substituents are C1-C15-alkyl, C1-C6-alkoxy, C5-C10-cycloalkyl or C5-C10-aryl; R2 and R3 are independently hydrogen or optionally substituted C1-C15-alkyl, C5-C10 cycloalkyl, C5-C10-heterocyclyl, C5-C10-aryl or C5-C10-heteroaryl, substituents are selected from the group consisting of C1-C15-alkyl, C5-C10-cycloalkyl and C5-C10-aryl or R2 and R3 together with the nitrogen atom form a five- or six-membered ring which optionally comprises one or more heteroatoms selected from O, S and N and bearing the substituent R4, R4 is hydrogen or C1-C6-alkyl; by reacting a reaction mixture comprising carbon dioxide, hydrogen and an alcohol of the formula R1—OH or an amine of the formula NHR2R3 in the presence of a catalyst comprising gold at a pressure from 0.2 to 30 MPa and a temperature from 20 to 200° C.
    Type: Grant
    Filed: July 26, 2012
    Date of Patent: April 22, 2014
    Assignee: BASF SE
    Inventors: Thomas Schaub, Rocco Paciello, Marek Pazicky, Giuseppe Fachinetti, Debora Preti
  • Patent number: 8614349
    Abstract: The present invention provides a method for oxidizing a hydrocarbon, an alcohol or an aldehyde, which comprises: oxidizing a hydrocarbon, an alcohol or an aldehyde to an alcohol, an aldehyde, a carboxylic acid or a carboxylate ester corresponding thereto, in a liquid phase having: a region in which oxygen is substantially present; and a region in which oxygen is substantially absent, in the presence of a catalyst containing a palladium, wherein the region in which oxygen is substantially absent is 0.1 to 10% by volume with respect to a total of the region in which oxygen is substantially present and the region in which oxygen is substantially absent.
    Type: Grant
    Filed: November 17, 2005
    Date of Patent: December 24, 2013
    Assignee: Asahi Kasei Chemicals Corporation
    Inventors: Koshiro Yokota, Tatsuo Yamaguchi, Toru Watanabe
  • Publication number: 20130281728
    Abstract: A compound having a structure of: wherein each of R1-R6 is individually H, halogen, hydroxyl, amino, optionally substituted alkoxy, optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted aryl, optionally substituted acyl, optionally substituted acyloxy, optionally substituted cycloalkyl, optionally substituted heterocycloalkyl, optionally substituted heteroaryl, optionally substituted aryloxy, optionally substituted heteroaryloxy, optionally substituted heterocycloxy, halogenated alkyl, thioether, optionally substituted thiol, ester, aminocarbonyl, amido, nitro, silyl, sulfinyl, sulfonyl, or phosphino.
    Type: Application
    Filed: April 18, 2013
    Publication date: October 24, 2013
    Inventors: Shih-Yuan Liu, Senmiao Xu
  • Publication number: 20130281664
    Abstract: The present invention relates to novel Ruthenium catalysts and related borohydride complexes, and the use of such catalysts, inter alia, for (1) hydrogenation of amides (including polyamides) to alcohols and amines; (2) preparing amides from alcohols with amines (including the preparation of polyamides (e.g., polypeptides) by reacting dialcohols and diamines and/or by polymerization of amino alcohols); (3) hydrogenation of esters to alcohols (including hydrogenation of cyclic esters (lactones) or cyclic di-esters (di-lactones) or polyesters); (4) hydrogenation of organic carbonates (including polycarbonates) to alcohols and hydrogenation of carbamates (including polycarbamates) or urea derivatives to alcohols and amines; (5) dehydrogenative coupling of alcohols to esters; (6) hydrogenation of secondary alcohols to ketones; (7) amidation of esters (i.e.
    Type: Application
    Filed: October 11, 2011
    Publication date: October 24, 2013
    Inventors: David Milstein, Ekambaram Balaraman, Chidambaram Gunanathan, Boopathy Gnanaprakasam, Jing Zhang
  • Publication number: 20130108882
    Abstract: An asphalt-containing substrate having an adhesive, coating or sealant composition applied to the substrate surface and adhesive, coating or sealant compositions are described herein. The composition resists softening of the asphalt compound in the asphalt-containing substrate at elevated temperatures and includes at least one base material and at least one plasticizer. The plasticizer has is a low molecular weight compound and preferably includes an ester-containing reaction product of at least one glycerol and at least one carboxylic acid or a glycol and an aryl carboxylic acid. The composition base material is preferably a polymer or copolymer that includes polyurethanes, silylated polyurethanes, silylated polyethers, copolymers thereof, and blends thereof. Products containing the composition and a method of applying the composition to a substrate are also disclosed herein.
    Type: Application
    Filed: October 31, 2012
    Publication date: May 2, 2013
    Applicant: HENRY COMPANY LLC
    Inventor: Henry Company LLC
  • Patent number: 8431655
    Abstract: The invention provides epoxy and oxetane compositions including the novel acyloxy and N-acyl curing agents described herein. Use of invention curing agents result in cured adhesive compositions with remarkably increased adhesion and reduced hydrophilicity when compared to resins cured with other types of curing agents. Furthermore, the curatives of this invention do not interfere with free-radical cure and are thus suited for use in hybrid cure thermoset compositions.
    Type: Grant
    Filed: June 15, 2010
    Date of Patent: April 30, 2013
    Assignee: Designer Molecules, Inc.
    Inventor: Stephen M Dershem
  • Patent number: 8409832
    Abstract: To provide a method for producing acetic acid from lignocellulose with high efficiency and a method for producing bioethanol. First, lignocellulose such as wood is decomposition-treated by a method such as pressurized hydrothermal treatment (Step S1). Then, the treatment solution obtained in Step S1 is acetic acid-fermented as a substrate using Clostridium thermoaceticum as an anaerobic microorganism in the presence of cysteine hydrochloride monohydrate at a concentration of 0.05 to 0.1 g/L (Step S2).
    Type: Grant
    Filed: March 3, 2011
    Date of Patent: April 2, 2013
    Assignee: Shiro Saka
    Inventors: Shiro Saka, Hisashi Miyafuji, Yoshihito Kohara, Haruo Kawamoto
  • Publication number: 20130065969
    Abstract: A compound of formula (I) wherein R1 and R2 are independently selected from hydrogen, methyl, ethyl, propyl and isopropyl; or R1 and R2 together form a saturated or monounsaturated 5- or 6-membered hydrocarbon ring, as represented by the arcuate dotted line; R3 is selected from methyl and ethyl; R4 is selected from methyl, ethyl, propyl, isopropyl, cyclopropyl, butyl, isobutyl, cyclobutyl and cyclopentyl; R5 is selected from hydrogen and methyl, and the dotted line between positions 3? and 4? represents an optional double bond. The compounds have a musk odour and are useful in fine and functional fragrances.
    Type: Application
    Filed: September 10, 2010
    Publication date: March 14, 2013
    Inventors: Philip Kraft, Urs Mueller
  • Publication number: 20130066091
    Abstract: A process for producing a chlorohydrin, an ester of a chlorohydrin, or a mixture thereof including the steps of contacting, in a hydrochlorination reactor, a multihydroxylated aliphatic hydrocarbon, an ester of a multihydroxylated aliphatic hydrocarbon, or a mixture thereof with a source of a hydrogen chloride, in the presence of a hydrophobic or extractable carboxylic acid catalyst is provided.
    Type: Application
    Filed: May 19, 2011
    Publication date: March 14, 2013
    Applicant: Dow Global Technologies LLC
    Inventors: Tina L. Arrowood, William J. Kruper, JR., John R. Briggs
  • Patent number: 8362292
    Abstract: A process for producing allyl acetate is disclosed. The process comprises reacting a feed comprising propylene, acetic acid, oxygen, and carbon dioxide in the presence of a supported palladium catalyst. The feed comprises from 2 to 6 mole percent carbon dioxide, which improves the selectivity to allyl acetate.
    Type: Grant
    Filed: August 10, 2012
    Date of Patent: January 29, 2013
    Assignee: Lyondell Chemical Technology, L.P.
    Inventors: Andrew P. Kahn, Elizabeth I. Ross-Medgaarden
  • Publication number: 20120184630
    Abstract: A compound of formula (I) wherein R1 and R2 are independently selected from hydrogen, methyl, ethyl, propyl and isopropyl; or R1 and R2 together form a saturated or monounsaturated 5- or 6-membered hydrocarbon ring, as represented by the arcuate dotted line; R3 is selected from methyl and ethyl; R4 is selected from methyl, ethyl, propyl, isopropyl, cyclopropyl, butyl, isobutyl, cyclobutyl and cyclopentyl; R5 is selected from hydrogen and methyl, and the dotted line between positions 3? and 4? represents an optional double bond. The compounds have a musk odour and are useful in fine and functional fragrances.
    Type: Application
    Filed: September 10, 2010
    Publication date: July 19, 2012
    Inventors: Philip Kraft, Urs Mueller
  • Publication number: 20120184748
    Abstract: A compound is useful as a recyclable catalyst for esterification or acylation of alcohols and consists of saccharine and a compound comprising a pyridine moiety. In addition, also a method of preparing the compound and an ester synthesis method using the compound are introduced.
    Type: Application
    Filed: May 25, 2011
    Publication date: July 19, 2012
    Applicant: NATIONAL TAIPEI UNIVERSITY OF TECHNOLOGY
    Inventors: NORMAN LU, WEN-HAN TU, CHIEH-KENG LI
  • Patent number: 8148570
    Abstract: Vinyl acetate is prepared by a) continuous gas-phase reaction of ethylene, acetic acid and oxygen at 1 to 30 bar and 130° C. to 200° C., the process heat being removed by heat exchange with water at 120° C. to 185° C. and 1 to 10 bar, b) the product gas stream consisting essentially of ethylene, vinyl acetate, acetic acid, water, carbon dioxide and further inert gases is fractionated, and c) all or part of the ethylene is recycled to the recycle gas process, wherein all or part of steam formed in the gas-phase reaction by heat exchange, with a temperature of from 120° C. to 185° C. and pressure of from 1 to 10 bar, is compressed by a differential pressure of at least 0.5 bar and used further.
    Type: Grant
    Filed: October 30, 2006
    Date of Patent: April 3, 2012
    Assignee: Wacker Chemie AG
    Inventor: Harald Michl
  • Patent number: 8138116
    Abstract: The application discloses a Titanium oxide composition and the application thereof. The mentioned Titanium oxide composition comprises Titanium co-precipitate(s), organic acid, diol, and water. According to this application, a catalyzed poly-esterification with said Titanium oxide composition is also disclosed. The mentioned polyesterification comprises a step of adding said Titanium oxide composition into at least one stage selected from slurry stage, esterification stage, and polycondensation stage.
    Type: Grant
    Filed: November 20, 2009
    Date of Patent: March 20, 2012
    Assignee: Far Eastern New Century Corporation
    Inventors: Hsin-Chin Ho, Ching-Tsu Peng, Shih-Fong Lee, Yui-Chi Lin, Chun-Wei Chen
  • Patent number: 8110700
    Abstract: The present invention relates to a process for preparing vinyl carboxylates, wherein a carboxylic acid is reacted with an alkyne compound in the presence of a catalyst which is selected from salts of perrhenic acid at a temperature of =250° C. The process gives rise to the desired vinyl esters with a high yield.
    Type: Grant
    Filed: May 15, 2008
    Date of Patent: February 7, 2012
    Assignee: BASF SE
    Inventors: Wolfgang Staffel, Roderich Roettger, Markus Christian Biel, Reinhard Kaczmarek
  • Patent number: 8080684
    Abstract: Methods and systems for the production of ethyl acetate are described herein. The methods and systems incorporate the novel use of a high shear device to promote dispersion and mixing of a carbonyl co-reactant (e.g. acetic acid, acetaldehyde) with ethanol. The high shear device may allow for lower reaction temperatures and pressures and may also reduce reaction time with existing catalysts.
    Type: Grant
    Filed: June 19, 2008
    Date of Patent: December 20, 2011
    Assignee: H R D Corporation
    Inventors: Abbas Hassan, Ebrahim Bagherzadeh, Rayford G. Anthony, Gregory Borsinger, Aziz Hassan
  • Patent number: 8062482
    Abstract: A method for removing acetaldehyde from a mixture of methyl acetate, methanol and acetaldehyde includes: (a) feeding the mixture of methyl acetate, methanol and acetaldehyde to a distillation column; (b) distilling the feed mixture of methyl acetate methanol and acetaldehyde at a pressure of 10 psig or more to generate an overhead vapor stream enriched in acetaldehyde as compared with the feed mixture and a residue stream depleted in acetaldehyde as compared with the feed mixture; and (c) withdrawing the residue stream depleted in acetaldehyde from the distillation column.
    Type: Grant
    Filed: October 30, 2007
    Date of Patent: November 22, 2011
    Assignee: Celanese International Corporation
    Inventor: R. Jay Warner
  • Patent number: 8053592
    Abstract: Provided that a method for inexpensively producing optically active ?-ionone with a high yield and a high asymmetric yield and with good workability in a short process, and a perfume composition comprising the optically active ?-ionone obtained by the aforementioned method. A method for producing optically active ?-ionone, comprising allowing ?-ionone as a mixture of optical isomers to react with an esterification agent, and hydrolyzing the obtained ?-ionone enol ester; a method for producing optically active ?-ionone comprising subjecting ?-ionone as a mixture of optical isomers to an asymmetric reduction, allowing the obtained optically active ?-ionol to react with an esterification agent to give an optically active ?-ionol ester, hydrolyzing the obtained optically active ?-ionol ester after purification as necessary, and then oxidizing the obtained optically active ?-ionol; and a perfume composition comprising thus obtained optically active ?-ionone.
    Type: Grant
    Filed: January 24, 2011
    Date of Patent: November 8, 2011
    Assignee: Takasago International Corporation
    Inventors: Tetsuya Yamamoto, Kenji Yagi, Kenya Ishida
  • Publication number: 20110269988
    Abstract: The present invention relates to a separation process for removing acetone from a mixture comprising acetone, methyl acetate and methyl iodide, said process comprising the steps of: (a) introducing said stream comprising acetone, methyl acetate and methyl iodide into a first distillation zone; (b) introducing acetic acid into said first distillation zone, either by addition of acetic acid to said stream comprising acetone, methyl acetate and methyl iodide or by introduction of acetic acid directly to the first distillation zone at one or more points at or above the point of introduction of said stream comprising acetone, methyl acetate and methyl iodide into the first distillation zone in step (a), or a combination of both; (c) removing from the first distillation zone an overhead stream comprising methyl iodide and a bottoms stream comprising acetone, methyl acetate, acetic acid, and a reduced amount of methyl iodide; (d) introducing into a second distillation zone the bottoms stream from step (c); (e) remov
    Type: Application
    Filed: December 23, 2009
    Publication date: November 3, 2011
    Inventors: Sean Anthony Hennigan, David Edward George Jeffers, Martin John Sellers, Stephen James Smith, Peter John Wilson
  • Publication number: 20110269709
    Abstract: The invention provides the compounds of formula (I) or pharmaceutically acceptable salts thereof. The invention also provides pharmaceutical compositions comprising one or more compounds of formula I or intermediates thereof and one more of pharmaceutically acceptable carriers, vehicles or diluents. The invention further provides methods of preparation and methods of use of prodrugs including NO-releasing prodrugs, double prodrugs and mutual prodrugs comprising the compounds of formula I.
    Type: Application
    Filed: December 23, 2010
    Publication date: November 3, 2011
    Inventor: Apparao Satyam
  • Publication number: 20110250159
    Abstract: The present invention pertains to a method of counteracting a malodor by introducing a malodor counteracting effective amount of an enantiomeric compound selected from the group consisting of (1R)-1-cyclohexylethyl butyrate and (1S)-1-cyclohexylethyl acetate.
    Type: Application
    Filed: June 21, 2011
    Publication date: October 13, 2011
    Inventors: Richard K Payne, Richard M. Boden, Mónica Diaz Sierra, Matthias H. Tabert
  • Publication number: 20110237825
    Abstract: A process for the carbonylation of dimethyl ether and/or methanol with carbon monoxide to produce methyl acetate and/or acetic acid in the presence of a catalyst formed by compositing a mordenite loaded with silver and/or copper, with an inorganic oxide binder.
    Type: Application
    Filed: November 16, 2009
    Publication date: September 29, 2011
    Inventors: Evert Jan Ditzel, David John Law, John Glenn Sunley
  • Patent number: 8026383
    Abstract: The invention relates to novel synthesis methods for the preparation of statin derivatives, which methods proceed by way of a key intermediate of formula I wherein X is halogen, acyloxy, activated hydrocarbyloxy, activated hydrocarbylthio or —N(CH3)OCH3, Ra is a hydroxy-protecting group and Rb is a carboxy-protecting group, and, as well as to the compound of formula I, to further new intermediates and methods for their preparation by Friedel-Crafts acylation.
    Type: Grant
    Filed: November 4, 2010
    Date of Patent: September 27, 2011
    Assignee: BASF SE
    Inventors: Reinhold Öhrlein, Gabriele Baisch, Nicole End, Stephan Burkhardt, Martin Studer
  • Publication number: 20110217654
    Abstract: The invention pertains to a compound generating an acid of the formula I or II, for instance corresponding sulfonium and iodonium salts, as well as corresponding sulfonyloximes wherein X is CH2 or CO; Y is O, NR4, S, O(CO), O(CO)O, O(CO)NR4, OSO2, O(CS), or O(CS)NR4; R1 is for example C1-C18alkyl, C1-C10haloalkyl, C2-C12alkenyl, C4-C30cycloalkenyl, phenyl-C1-C3-alkyl, C3-C30cycloalkyl, C3-C30cycloalkyl-C1-C18alkyl, interrupted C2-C18alkyl, interrupted C3-C30cycloalkyl, interrupted C3-C30cycloalkyl-C1-C18alkyl, interrupted C4-C30cycloalkenyl, phenyl, naphthyl, anthracyl, phenanthryl, biphenylyl, fluorenyl or heteroaryl, all unsubstituted or are substituted; or R1 is NR12R13; R2 and R3 are for example C3-C30cycloalkylene, C3-C30cycloalkyl-C1-C18alkylene, C1-C18alkylene, C1-C10haloalkylene, C2-C12alkenylene, C4-C30cycloalkenylene, phenylene, naphthylene, anthracylene, phenanthrylene, biphenylene or heteroarylene; all unsubstituted or substituted; R4 is for example C3-C30cycloalkyl, C3-C30cycloalkyl-C1-C18al
    Type: Application
    Filed: February 16, 2011
    Publication date: September 8, 2011
    Applicant: BASF SE
    Inventors: Hitoshi Yamato, Toshikage Asakura, Akira Matsumoto, Keita Tanaka, Yuichi Nishimae
  • Publication number: 20110201809
    Abstract: A process of making entecavir comprising converting a compound of formula (M5) to entecavir, wherein the two PGs on the formula (M5) are taken together to form an optionally substituted six- or seven-member cyclic ring.
    Type: Application
    Filed: February 15, 2011
    Publication date: August 18, 2011
    Inventors: Tsung-Cheng Hu, Hung-Tsung Huang
  • Publication number: 20110166372
    Abstract: A process for producing an optically active cyclopropanecarboxylic acid ester compound represented by the formula (4): (wherein R5, R6 and * each represents the same meaning as defined below), comprising reacting a diazoacetic acid ester represented by the formula (2): N2CHCO2R5??(2) (wherein R5 represents an alkyl group having 1 to 15 carbon atoms or the like) with a compound represented by the formula (3): (wherein R6 represents an alkyl group having 1 to 15 carbon atoms or the like), in the presence of an asymmetric copper complex obtained by reacting a copper compound and an optically active salicylideneaminoalcohol compound represented by the formula (1): (wherein R1 represents an alkyl group having 1 to 4 carbon atoms or the like, R2 represents a hydrogen atom or the like, R3 and R4 independently represent a hydrogen atom or the like, and * represents an asymmetric center).
    Type: Application
    Filed: September 7, 2009
    Publication date: July 7, 2011
    Inventors: Katsuhisa Masumoto, Kouji Yoshikawa
  • Patent number: 7964751
    Abstract: Disclosed are enantiomers of amino-phenyl-acetic acid octadec-9-(Z)-enyl ester, and salts thereof, including pharmaceutical compositions, uses and a process for the manufacture thereof.
    Type: Grant
    Filed: February 25, 2008
    Date of Patent: June 21, 2011
    Assignee: Yeda Research and Development Co. Ltd.
    Inventors: Yaacov Herzig, Jeffrey Sterling, Vladimir Ioffe, Yuriy Raizi, Istvan Miskolczi, Andras Zekany
  • Publication number: 20110124892
    Abstract: The present invention relates to a process for converting a multihydroxylated-aliphatic hydrocarbon or ester thereof to a chlorohydrin, by contacting the multihydroxylated-aliphatic hydrocarbon or ester thereof starting material with a source of hydrogen chloride at superatmospheric, atmospheric and subatmospheric pressure conditions for a sufficient time and at a sufficient temperature, preferably wherein such contracting step is carried out without substantial removal of water, to produce the desired chlorohydrin product; wherein the desired product or products can be made in high yield without substantial formation of undesired overchlorinated byproducts; said process carried out without a step undertaken to specifically remove volatile chlorinated hydrocarbon by-products or chloroacetone, wherein the combined concentration of volatile chlorinated hydrocarbon by-products and chloroacetone is less than 2000 ppm throughout any stage of the said process.
    Type: Application
    Filed: January 31, 2011
    Publication date: May 26, 2011
    Inventors: William J. Kruper, JR., Tina Arrowood, Bruce Michael Bell, John Briggs, Robert M. Campbell, Bruce D. Hook, Anh Nguyen, Curt Theriault, Ralf Fitschen
  • Publication number: 20110118500
    Abstract: Provided that a method for inexpensively producing optically active ?-ionone with a high yield and a high asymmetric yield and with good workability in a short process, and a perfume composition comprising the optically active ?-ionone obtained by the aforementioned method. A method for producing optically active ?-ionone, comprising allowing ?-ionone as a mixture of optical isomers to react with an esterification agent, and hydrolyzing the obtained ?-ionone enol ester; a method for producing optically active ?-ionone comprising subjecting ?-ionone as a mixture of optical isomers to an asymmetric reduction, allowing the obtained optically active ?-ionol to react with an esterification agent to give an optically active ?-ionol ester, hydrolyzing the obtained optically active ?-ionol ester after purification as necessary, and then oxidizing the obtained optically active ?-ionol; and a perfume composition comprising thus obtained optically active ?-ionone.
    Type: Application
    Filed: January 24, 2011
    Publication date: May 19, 2011
    Applicant: TAKASAGO INTERNATIONAL CORPORATION
    Inventors: Tetsuya Yamamoto, Kenji Yagi, Kenya Ishida
  • Publication number: 20110062392
    Abstract: The present disclosure provides various methods and systems for manufacture, transport and delivery of material including highly polarized nuclei that is in a hyperpolarized state.
    Type: Application
    Filed: September 10, 2010
    Publication date: March 17, 2011
    Applicant: Millikelvin Technologies LLC
    Inventors: Neal Kalechofsky, Avrum Belzer