Abstract: A paraffin refill or package system or article wherein the paraffin mixture is provided in a large total volume which has preselected portions or sub-volumes which are defined by a divider structure. The sub-volumes or portions are preferably cube shaped. In use, a single carton containing the paraffin refill or system is opened. One or more portions or cubes of the system are added to the bath apparatus reservoir and heated. The user then observes the resultant liquefied mix to determine whether additional portions of the system are necessary. Any remaining portions of the system are saved in the carton.

Abstract: The present invention relates to gel compositions comprising alkyl amides of tri-basic carboxylic acids and methods of making gel compositions.

Abstract: The present invention relates to a rinse-off antimicrobial cleansing composition comprising from about 0.1% to about 5% of an antimicrobial active, from about 8% to about 18% of an anionic surfactant, from about 2% to about 12% of a proton donating agent; from about 1% to about 30% of a lipophilic skin moisturizing agent; from about 0.1% to about 4% of a stabilizer; and from about 35% to about 88.8% of water. At least about 67% of the anionic surfactant comprises a mixture of Class A and Class C surfactant. The weight ratio of Class A surfactant to Class C surfactant ranges from about 5:1 to about 1:2. The composition is adjusted to a pH of from about 3.5 to about 4.5.

Abstract: The present invention relates to a rinse-off antimicrobial cleansing composition comprising from about 0.001% to about 5% of an antimicrobial active, from about 1% to about 80% of an anionic surfactant, from about 0.1% to about 12% of a proton donating agent; and from about 3% to about 98.899% of water, wherein the composition is adjusted to a pH of from about 3.0 to about 6.0, wherein the rinse-off antimicrobial cleansing composition has a Gram Positive Residual Effectiveness Index of greater than about 1.8, and wherein the rinse-off antimicrobial cleansing composition has a Mildness Index of greater than 0.3. The invention also encompasses methods for cleansing skin and providing residual effectiveness versus Gram positive bacteria using these products.

Abstract: A cosmetic hair composition comprising, in a cosmetically acceptable medium, at least one ceramide compound and at least one agent for screening out ultraviolet radiation containing at least one sulphonic acid radical. The invention also relates to a process of including a ceramide compound in a cosmetic hair composition containing a UV screening agent containing at least one sulphonic acid radical, in order to improve the fixing of the UV screening agent to the hair.

Abstract: A process for preparing a photochromic compound and/or improving the photochromic properties of a photochromic compound selected from metal oxides, hydrated metal oxides and metal oxide/hydrate complexes by heat-treating the photochromic compound in the presence of at least one metallic component such as an oxide or hydroxide of lithium, sodium and/or potassium, the photochromic compound obtained using this process, and the cosmetic composition comprising it.

Abstract: The present invention relates to a substantially dry, disposable, personal cleansing product useful for both cleansing and consistently conditioning the skin or hair. These products are used by the consumer by wetting the dry product with water. The product comprises of a water insoluble substrate, a lathering surfactant, and a conditioning component having a lipid hardness value of at least about 0.02 kg. This invention also encompasses methods for providing consistent deposition of conditioning agents to the skin or hair. The invention also encompasses methods for cleansing and conditioning the skin or hair using these products and to methods for manufacturing these products.

Abstract: A composition for cosmetics use which comprises a lysophospholipid mixture, wherein 30 mol % or more of fatty acids bonded to said lysophospholipid mixture are monoenoic fatty acids; and a cosmetic composition which comprises a lysophospholipid mixture and a cosmetically acceptable carrier, wherein 30 mol % or more of fatty acids bonded to said lysophospholipid mixture are monoenoic fatty acids. The cosmetic composition having such a lysophospholipid mixture has high storage stability and is excellent in feeling upon use.

Abstract: An oily composition comprises a solid phase containing a water-soluble effective substance and/or a water-dispersible effective substance and an oil phase containing an oily component and an emulsifying agent having an HLB value of not more than 10, wherein the solid phase is dispersed in the oil phase in the form of a fine particulate state having an average particle size of not more than 5 &mgr;m and the water content or the aqueous alcohol solution content of the solid phase is not more than 30% by weight.

Abstract: Embodiments include a liquid colorant composition having an acrylates/octylacrylamide copolymer, a cellulose material, alcohol and a colorant. The cellulose material may be hydroxypropylcellulose. Isostearyl alcohol and silica may be included in the composition to enhance properties such as the spreadability and feel of the composition on the lips. Additional additives such as fragrance and botanical extracts may also be added. Such compositions can be easily applied to the lips and offer long wear characteristics.

Abstract: A composition for application to fingernails and toe nails includes a binder and a pigment, the binder including volatile and non-volatile components and the pigment being present in the composition in an amount of between 30% to 40% of the total volume of the non-volatile portion of the composition, creating a physical action upon drying of a layer of the composition applied to the nails, wherein a lack of cohesive strength between the pigment and binder results in formation of random cracks in the applied layer.

Abstract: A blackhead-removing face pack sheet with superior ease of use and blackhead-removing capacity is provided. The blackhead-removing face pack sheet 1 is formed from a laminate which comprises a gas-permeable and flexible base layer 2 and a pack material layer 3 the primary component of which is a copolymer of vinyl acetate and N-vinyl-2-pyrrolidone. The base layer 2 comprises a porous material such as a nonwoven fabric, and part of it is impregnated or embedded with the pack material constituting the pack material layer 3. This gives a high force of adhesion between the base layer 2 and the pack material layer 3.

Abstract: The present invention relates to injectable suspensions of bio-active glass and dextran or a dextran derivative for the repair of soft tissue or hard bone in mammals, especially humans. In one embodiment, the dextran derivatives include free radical polymerizable groups, which can be polymerized following injection into a patient.

Abstract: An anti-oxidizing composition for scavenging free radicals, comprising at least one essential oil component containing a number of fat-soluble, low-molecular-weight compounds, a pharmaceutical composition comprising the above composition, and a process for preparing the same are described. Percutaneous absorption of the pharmaceutical composition is effective in treating immune diseases, particularly AIDS.

Abstract: A ready-to-use water dispersible pigment composition containing at least 5% by weight of water is provided. The composition comprises a stable dispersion of a water-insoluble and/or hydrophobic natural pigment such as a carotenoid, curcumin, a porphyrin pigment or vegetables carbon black in the form of bodies of an average size which is at the most 10 &mgr;m is provided. The pigment bodies are dispersed without the use of a surface active substance in an aqueous phase comprising a hydrocolloid. The natural pigment in compositions which are useful for coloring of food products and pharmaceuticals do not migrate in the products. The compositions are useful in coating compositions for tablets and dragees.

Abstract: A method of preparing an extract of at least one active principle in the form of completely dry soluble granules wherein an extract of an active principle is prepared in a solvent medium and depositing the extract upon the internal and external walls of microporous carriers that are insoluble in the solvent, drying the impregnated granules, and coating the walls of the granules with a film forming polymer. The granules are a soluble dietary fiber based upon a polymer selected from the group comprising inulin and oligofructoses and, fructo-oligosaccharides separately or mixed.

Abstract: A material with excellent selective absorption of super antigens. Said material contains urea bonds or thiourea bonds and remains active even in a high protein concentration solution in the neutral region, Activity remains after sterilization. Also provided is a body fluid purifying column for eliminating or detoxification of super antigens. In addition to that, this invention provides a wound dressing material with super antigen adsorbing properties.

Abstract: A device for the release of substances from pressure sensitive hot-melt adhesives with a uniform or non-uniform distribution of said substances is characterized by the fact that the pressure sensitive hot-melt adhesive is hydrophilic and comprises at least one water-soluble, or at least water-swellable, polymer, at least one water-soluble, meltable adhesive resin, as well as substance to be released.

Abstract: A sustained/immediate acting ketoprofen patch. A moisture permeable backing, a moisture non-permeable primer, a moisture high-permeable drug layer containing ketoprofen and a skin adhesion layer controlling release of a drug solution are piled up. An ethyl acetate soluble acrylic/rubber adhesive is coated onto a silicon coated paper, dried and transfer coated onto the backing to form the primer. The drug layer is formed by coating a drug solution onto a silicon coated paper, drying and transfer coating onto the primer. The skin adhesion layer is formed by coating a mixture of a solution prepared by dissolving an emulsifier in ethyl acetate and acrylic adhesive, drying and transfer coating onto the drug layer. The ketoprofen patch has a drug release controlling function and a good adhesion strength. The drug transferring effect through the skin is good.

Abstract: The present invention provides a number of screening methods for evaluating compounds capable of suppressing cytokine production either in vitro or in vivo. The methods generally involve stimulating the production of a cytokine in a cell, exposing a portion of the cells to a putative cytokine modulating agent and determining subsequent levels of cytokine production in the cells. Additionally, the present invention provides certain compounds identified by this method.

Abstract: The present invention provides a method of achieving the time-specific delivery of a pharmaceutically active agent to a patient in need of the therapeutic effects of the pharmaceutically active agent. The method includes administering a pharmaceutical formulation comprising (a) a core including the pharmaceutically active agent to be delivered, and (b) a swellable polymeric coating layer substantially surrounding the core. The swellable polymeric coating layer delays the release of the pharmaceutically active agent from the core for a predetermined period of time dependent upon the thickness of the swellable polymeric coating layer. The swellable polymeric coating layer surrounding the core is provided by a new method which includes alternately (I) wetting the core with a binder solution, and (ii) coating the core with powdered polymeric particles a sufficient number of times to produce a time-specific dosage formulation having the desired thickness of swellable polymeric coating layer.

Abstract: This invention provides folic acid-containing pharmaceutical compositions comprising either an oral contraceptive or a hormone replacement composition. This invention also provides methods of administering folic acid to a subject using the instant pharmaceutical compositions. Finally, this invention provides a drug delivery system useful for administering the instant pharmaceutical compositions.

Abstract: The present invention relates to a process for producing a chitosan-containing soft capsule. The process includes the steps of rendering chitosan a powder; adding the chitosan powder, powder comprising an organic acid and a salt thereof, and an emulsifier to an oil or fat; stirring the resultant mixture so as to suspend the powders, to thereby obtain a gel-like stock; and feeding the gel-like stock and a gelatin solution for coating into an automated encapsulation machine, to effect encapsulation of the stock with gelatin.

Abstract: This invention provides a pharmaceutical composition comprising a non-peptide osteogenesis-promoting substance and a polyethylene glycol or a derivative thereof, which can be advantageously used as a agent for preventing or treating various bone diseases (e.g., osteoporosis) in view of the high oral absorbability and stability of the active ingredient.

Abstract: Thyroxine medications which include combinations of levothyroxine, and/or liothronine, or dextrothyroxine, or thyroid, and one or more iodine salts, or iodine donor compounds are described, which produce a stable thyroxine medication, with a long shelf life. A method for manufacturing the medications is also described.

Abstract: The effervescent formulation elation in the form of granules or of a tablet contains, in addition to the effervescent base, at least one water-soluble or at least suspendable plant extract whose particles are coated with at least one oily, fatty or waxy substance. At least one emulsifier and/or at least one antifoam may be present in the coating and/or as a further component of the mixture, in particular applied as a further component of the mixture to a pharmaceutically permissible filler as carrier. The individual phases are prepared by a procedure in which the plant extract or the filler is heated—preferably in a granulator, in particular in a vacuum granulator—and wet or mixed with a melt or solution of the oily, fatty or waxy substance or at least one emulsifier and/or at least one antifoam and then dried—preferably in a vacuum—and sieved to the desired particle size.

Abstract: The invention provides a pharmaceutically acceptable solid oral formulation of olanzapine and a process for making such formulation.

Abstract: The present invention describes a surprising new and effective pharmaceutical composition comprising microparticles and a pharmaceutically acceptable carrier. In particular, the present invention describes a pharmaceutical composition containing microparticles off a matrix material into which is infused a therapeutic agent. The present invention further provides a method of infusing a therapeutic agent such as a protein or peptide into a matrix material to form microparticles containing said therapeutic agent by employing a compressed solvent which is normally gaseous at ambient temperature and pressure. A method is also disclosed of treating or preventing a disease in a mammal by administering to said mammal through a mucosal membrane an effective amount of a pharmaceutical composition comprising microparticles containing a therapeutic agent which effectively treats the disease or disorder.

Abstract: Disclosed is a method of producing a sustained-release preparation for injection, which comprises adding to microspheres which are obtained from w/o emulsion with a solution containing a physiologically active peptide as an internal aqueous phase and a solution containing a polylactic acid having a weight-average molecular weight of about 5,000 to about 25,000 as an oil phase, a sugar in an amount of about 2 to about 60% (w/w) relative to the microspheres; freeze drying and subsequent heating at the temperature ranging from the glass transition temperature of the microspheres to the temperature which is higher by about 20° C. than the glass transition temperature for about 24 to about 120 hours; and the method of the present invention suppresses microsphere particle aggregation during production process, makes it possible to almost perfectly remove the water and organic solvent in microspheres, and yields microspheres having good dispersibility and storage-stability.

Abstract: A composition for delivering a stable, bioactive compound to a subject comprising a first component and a second component, the first component comprises microparticles of sugar glass or a phosphate glass containing the bioactive agent. The sugar glass or phosphate glass optionally includes a glass formation facilitator compound, and the second component comprises at least one biocompatible liquid perfluorocarbon in which the first component is insoluble and dispersed. The liquid perfluorocarbon optionally includes a surfactant.

Abstract: A sustained-release preparation containing a bioactive polypeptide is prepared using a starting material containing a lyophilized product of an aqueous solution or suspension of the bioactive polypeptide in a non-ionic surfactant. The lyophilized product is dispersed in an oil phase, which further contains a biocompatible, biodegradable polymer.

Abstract: A subliming propolis solid composition having a subliming function to stably give an excellent sense of fragrance and being useful as an atmosphere-ameliorating agent, the composition comprising (A) a propolis mass and/or an extraction residue thereof, (B) water alone or a mixture of water with a water-soluble solvent capable of forming a hydrogen bond with water, (C) a surfactant and (D) a hydrophilic polymer compound, the subliming propolis solid composition containing, per 100 parts by weight of total of the components (A) and (B), 0.01 to 25 parts by weight of the component (C) and 0.1 to 50 parts by weight of the component (D).

Abstract: The present invention provides methods and compositions for promoting healing of damaged tissue that result in an increased level of nitric oxide in the vicinity of the damaged tissues. Also provided are methods and compositions for inhibiting unwanted wound healing by inhibiting the activity of nitric oxide in the tissue.

Abstract: A coating syrup is made using an emulsion of an emulsifier and either an oil-based flavoring agent, a food acid or both. The emulsion may be used to coat comestibles, such as pellets of chewing gum. The emulsion helps to retain volatile flavors that may otherwise flash off during the coating operation.

Abstract: A gum base including a siloxane polymer, a polar polymer and optionally a filler, chewing gums made from the gum base as well as methods for manufacturing chewing gum and gum bases are disclosed.

Abstract: A strain of bread-mixing yeast for use in obtaining fresh bread-making yeasts: giving at least 100 ml in 2 hours at 30° C. in test A1, preferably at least 110 ml., more preferably at least 150 ml; complying with the following ratio: release ⁢   ⁢ of ⁢   ⁢ CO 2 ⁢   ⁢ in ⁢   ⁢ 48 ⁢   ⁢ hours ⁢   ⁢ at ⁢   ⁢ 8 ⁢ ° ⁢   ⁢   ⁢ C .

Abstract: The present invention provides efficient, selective and economical methods for producing cereal suspensions having the aroma and/or flavor of natural cereals and for modifying the viscosity and/or sugar kind of cereal suspensions. The methods include treating a cereal substrate suspension with an enzyme preparation which comprises at least one hydrolase having the ability to hydrolyze &agr;-glycosidic bonds and having no glucanase and proteinase effect. The hydrolase may be selected from the group consisting of &bgr;-amylase, &agr;-amylase, amyloglucosidase and pullulanase, with the proviso that when the enzyme preparation comprises &bgr;-amylase or (&agr;-amylase there is always a mixture of at least one other of the &agr;-glycosidic hydrolases. In addition to the above-identified hydrolases, the enzyme preparations of the present invention may further comprise an isomerase, such as glucose isomerase.

Abstract: A flavor enhancer which is low in monosodium glutamate, which is substantially free of 5′-IMP and 5′-GMP and which enhances both meat, vegetable and diary flavors. The use of the flavor enhancer in flavoring compositions and food and feed applications.

Abstract: A method of preserving produce by providing a plastic packaging material having a thickness of up to about 500 microns and a permeability to water vapor exceeding about 1.5 g mm m−2 per day at 38° C. and 85-90% relative humidity, whereby when the material is used to package produce, no condensation or minimal condensation appears on a surface of the material. Related methods and products produced thereby are also described and claimed.

Abstract: Precooked, packaged ground meat products and methods of making such products. The product comprises ground meat and at least one moisture-absorbing additive. The formulated meat mixture is formed into a raw ground meat portion. Perforations are formed in the raw ground meat portion. The perforated raw ground meat portion is sealed within a closed envelope and cooked. The moisture-absorbing additive and perforations control the purge (water and other juices) discharged by the meat during cooking. The moisture-absorbing additive absorbs some of this purge; the perforations trap much of the remaining purge. The resulting product is thus without large amounts of free purge within the package and may be broken apart easily into cooked ground meat upon removal from the package. The raw meat should be frozen and maintained frozen until cooking to maintain the grain structure and perforations during handling.

Abstract: A cold-storage method of a kimchi jar whereby kimchi is thawed after selectively input freezing time lapses to thereafter refrigerate same, so that the kimchi is prevented from being naturally aged to enable to enjoy fresh flavor of the kimchi for a long time, the method comprising the steps of: maintaining an in-chamber temperature at an established cold storage temperature for a cold storage period of time established by a manipulating unit to thereby refrigerate the kimchi; and maintaining the in-chamber temperature at a refrigerated storage temperature when the established cold storage period of time lapses, to thaw and thereafter to cold storage the kimchi stored in the cool chamber.

Abstract: A process for the foaming of the headspace of containers filled with carbonated beverages, wherein, after the filling of the beverages into the containers, the containers are transferred to a foaming area, in which an electromagnetic beam, preferably a laser beam, is irradiated in a controlled way into the headspace of the container which is not filled with the beverage, whereby, due to the resultant foaming, the gas volume in the headspace is displaced from it, and the containers are subsequently sealed, as well as to a device for carrying out the process.

Abstract: Filled wafer blocks are made by feeding preliminary blocks at a lower level to a stacking station and then feeding a wafer sheet coated on an upper side with a spread to that location, gripping them and inverting them as they are laid on the lower block to form a filled block in the production of filled wafers and the like. The filled wafer blocks can also have uncoated sheets laid onto the blocks.

Abstract: A method for producing edible quality refined fish oil comprising the steps of extracting press liquor from a cooked fish, wherein the press liquor consists primarily of fish oil and water inherent in the cooked fish. The fish oil is from the group of fish consisting of menhaden, other similar fish, and mixtures thereof. Enzymes present in the press liquor are deactivated by injecting an acidic solution into said press liquor. After the fish oil is removed from the press liquor, the fish oil is cold filtered to produce an olein fraction and a stearine fraction. The stearine fraction is separated from the olein fraction and fatty acids that remain in the olein fraction are removed. Then bleaching the fish oil by mixing amorphous silica and diatomaceous earth with the fish oil, under vacuum conditions, and deodorizing the fish oil under vacuum conditions with steam injection. Finally, preparing the fish oil for storage by mixing a chelating agent and anti-oxidants with fish oil.

Abstract: A method for preparing a natural product including crushing and dejuicing muscadine grapes. The method includes breaking down the pulp of the crushed and dejuiced muscadines through heating the pomice and enzymatic action through a predetermined period. The method further includes removing the broken down pulp from the pomice. The method further includes placing the skins and seeds of the extruded pulp into net bags and closing the bags and placing the bags in a dryer at an elevated temperature and drying the contents of the bags to a predetermined moisture. The method further includes bagging the dried material and storing the food-grade containers in a room at a predetermined temperature and finely grinding the dried material.

Abstract: Apparatus (10) is disclosed including first and second forming rollers (18, 21) which rotatably abut with an anvil roller (20). The forming rollers (18, 21) each include a periphery forming a continuous forming surface including a plurality of axially and circumferentially spaced grooves (24) each formed as a continuous depression arranged in a serpentine and non-intersecting manner. Food (14) is simultaneously fed between a continuous strip of support material (16) and a continuous ribbon of film material (66) as they pass between a first abutment nip of the first forming roller (18) and the anvil roller (20). After extending partially around the periphery of the first forming roller (18), the materials (16, 66) and the food therebetween pass around an adjustable idler roller (70) to between a second abutment nip of the second forming roller (21) and the anvil roller (20).

Abstract: An apparatus for making citrus juice preferably includes a supply of relatively small frozen bodies comprising at least one of citrus juice and pulp, a heating section for adding heat to the frozen bodies to thaw the frozen bodies, and a filling section downstream from the heating section for filling juice containers with citrus juice. The relatively small frozen bodies may have at least one dimension less than about 1.5 inches. The apparatus may also include a pasteurizing section upstream from the filling section. In one embodiment, the supply comprises a plurality of portable containers each containing a plurality of frozen bodies. The heating section preferably comprises a heat transfer tank, a heat transfer fluid in the heat transfer tank, a heater for the heat transfer fluid, and a conveyor for advancing the containers of frozen bodies through the heat transfer fluid. Each portable container may comprise a flexible bag, for example.

Abstract: The present invention pertains to a food ingredient comprising one or more sterols, one or more fats and one or more emulsifiers, as well as to methods of making the food ingredient and food compositions comprising the food ingredient The food ingredient can be used as a cholesterol-lowering agent.

Abstract: The invention provides a spread which contains phospholipids, has a 60% or less than 60% by weight oil phase, and exhibits an increase in conductivity at 36° C. to 0.2 mS/cm or more than 0.2 mS/cm in 300 seconds, and as such, forms a stable emulsion to produce a highly stable product, and when ingested, melts well and rapidly demulsifies to yield a sufficiently satisfying flavor.

Abstract: A process for the preparation of a substantially free flowing particulate flavor by mixing an oil soluble flavor with a melted edible fat having a melting point from about 30° C. (85° F.) to 93° C. (200° F.) to form a solution of the oil soluble flavor in the melted fat, cooling the solution of the oil soluble flavor in the melted fat, with the addition of a super-cooling agent with agitation during cooling, to produce solid particles having an average diameter of from about 0.1 to 10 cm, and then, if desired, grinding these particles with a super-cooling agent to produce the substantially free flowing particulate flavor whose particles have an average diameter of less than 1 mm.