Patents Issued in February 20, 2001
  • Patent number: 6190622
    Abstract: An apparatus for producing ozone from oxygen comprises a high voltage electrode connectable to a current source; a ground electrode spaced from the high voltage electrode and having an upstream end and a downstream end; a dielectric element positioned between the high voltage electrode and the ground electrode; a path for air flow positioned between the dielectric element and the ground electrode; and, a current collector positioned downstream of the high voltage electrode and comprising an extension of the ground electrode.
    Type: Grant
    Filed: November 19, 1999
    Date of Patent: February 20, 2001
    Assignee: Fantom Technologies Inc.
    Inventors: Wayne Ernest Conrad, Helmut Gerhard Conrad, Ted Szylowiec, Richard Stanley Philips
  • Patent number: 6190623
    Abstract: An apparatus is provided which comprises two burner zones using a single igniter separated by a heat transfer zone for use in low-cost hydrogen generation units. When used in conjunction with a control system which limits the effluent temperature to less than about 700° C., the apparatus can be constructed of materials such as carbon steel and stainless steel rather than more exotic materials. This simplified structure and the use of less exotic materials provides an efficient, low-cost combined partial oxidation reactor for small-scale hydrogen production systems, especially for hydrogen production systems associated with fuel cell operation for the production of electricity.
    Type: Grant
    Filed: June 18, 1999
    Date of Patent: February 20, 2001
    Assignee: UOP LLC
    Inventors: Robert J. Sanger, Gavin P. Towler, Kishore J. Doshi, Kurt M. Vanden Bussche, John J. Senetar
  • Patent number: 6190624
    Abstract: The apparatus for indirectly exchanging heat with narrow channels in a heat exchange type channel reaction zone uses plates containing partially perforated sections to simplify or eliminate the use of manifolds to distribute to and collect different fluids from the various channels. The invention simplifies the operation by directly communicating adjacent channels across sections of perforations located at one end or the other of the channels. The arrangement of this invention provides the advantage of more compact heat exchanging reactor arrangements. In this manner, multiple pass channels can be contained in a single plate channel arrangement using only single or double distribution manifolds at the ends of the channels. The arrangement of the invention can also simplify the use of a single manifold arrangement at one end of the channels to facilitate catalyst unloading and catalyst replacement in the reaction channels.
    Type: Grant
    Filed: September 8, 1998
    Date of Patent: February 20, 2001
    Assignee: UOP LLC
    Inventor: Jacques J. L. Romatier
  • Patent number: 6190625
    Abstract: The present invention provides a method for fluidized bed roasting of molybdenite to molybdenum trioxide. A fluid bed reactor separated into separate zones is used to provide plug flow conditions. A cooling tube is submerged in the fluid bed to control temperature. A vibrator is used to enhance fluidization.
    Type: Grant
    Filed: August 7, 1997
    Date of Patent: February 20, 2001
    Assignee: Qualchem, Inc.
    Inventors: Mahesh C. Jha, William A. May
  • Patent number: 6190626
    Abstract: The method of the present invention detoxifies spent aluminum potliners to remove hazardous cyanides, fluorides, and polynuclear aromatics by reacting crushed potliners with a CaCl2/HCl leach mill solution in the presence of iron. The method produces a solid waste suitable for landfill disposal and a recyclable reaction liquor. The reaction to destroy the polynuclear aromatics preferably occurs at a pH of no more than about 0.2, at about 120° C. and 80 psig following destruction of the cyanides and converting of the fluorides to florspar in an initial oxidation at a lower temperature, lower pressure, and higher pH.
    Type: Grant
    Filed: February 22, 1999
    Date of Patent: February 20, 2001
    Inventor: Joseph B. Cashman
  • Patent number: 6190627
    Abstract: Method for treating atmospheric pollutants by contacting the atmosphere with a catalyst composition or adsorptive material coated on the surface of a substrate in which the catalyst composition or adsorptive material is protected from degradation by harmful contaminants contained in the atmosphere by a coating of at least one porous protective material and a device useful therefor.
    Type: Grant
    Filed: November 30, 1999
    Date of Patent: February 20, 2001
    Assignee: Engelhard Corporation
    Inventors: Jeffrey B. Hoke, Ronald M. Heck, Fred M. Allen
  • Patent number: 6190628
    Abstract: A method and apparatus for optimizing the injecting of NOx inhibiting liquid reagent into the flue gas of a utility or industrial type boiler to reduce emissions of NOx including a temperature sensor for measuring the boiler flue gas temperature and a moveable conduit for injecting the NOx inhibiting reagent into the flue gas at a sensed predetermined temperature range.
    Type: Grant
    Filed: June 28, 1994
    Date of Patent: February 20, 2001
    Assignee: Diamond Power International, Inc.
    Inventor: H. Randy Carter
  • Patent number: 6190629
    Abstract: A scrubber assembly for removal of water soluble and/or alkaline gases from an exhaust stream uses a scrubber mixture contained within at least one scrubber vessel. Preferably the scrubber mixture include a liquid phase including an aqueous acid solution, and solid phase including a solid organic acid. Preferably, the scrubber mixture includes a solid carboxylic acid having low toxicity and low corrosiveness to system components. In one embodiment, a plurality of scrubber vessels, each containing the scrubber mixture are connected in series. The scrubber assembly may further include an indicator tank containing an indicator mixture. The pH of the scrubber mixture and/or indicator mixture may be monitored, thereby making operation of the system not only simpler and more reliable, but also more efficient. A method for removal of water soluble and/or alkaline gases from an exhaust stream is also disclosed.
    Type: Grant
    Filed: April 16, 1999
    Date of Patent: February 20, 2001
    Assignee: CBL Technologies, Inc.
    Inventors: Glenn S. Solomon, David J. Miller, Tetsuzo Ueda
  • Patent number: 6190630
    Abstract: This invention provides a flue gas treating process for removing sulfur oxides and dust from exhaust gas containing sulfur oxides and dust by using an absorption tower into which an absorbing fluid containing an alkaline agent is sprayed, comprising the steps of equipping the absorption tower with integrally formed dust collection means comprising dust collecting plates and discharge electrodes, and with dust separation means for sweeping off the dust collected by the dust collection means; and treating the exhaust gas in the dust collection means and subsequently cleaning the exhaust gas in the absorption tower, whereby desulfurization and dust removal are effected while sweeping off the collected dust by the dust separation means. Thus, desulfurization and dust removal can be effected in a simple manner, and the capacity of an electrostatic precipitator installed on the upstream side can be reduced.
    Type: Grant
    Filed: February 20, 1998
    Date of Patent: February 20, 2001
    Assignee: Mitsubishi Heavy Industries, Ltd.
    Inventors: Masakazu Onizuka, Toru Takashina, Kiyoshi Okazoe, Hiroyuki Katayama
  • Patent number: 6190631
    Abstract: A single crystal silicon wafer which, during the heat treatment cycles of essentially any electronic device manufacturing process, will form an ideal, non-uniform depth distribution of oxygen precipitates. The wafer is characterized in that is has a non-uniform distribution of crystal lattice vacancies, the concentration of vacancies in the bulk layer being greater than the concentration of vacancies in the surface layer and the vacancies having a concentration profile in which the peak density of the vacancies is at or near a central plane with the concentration generally decreasing from the position of peak density in the direction of a front surface of the wafer. In one embodiment, the wafer is further characterized in that it has a first axially symmetric region in which vacancies are the predominant intrinsic point defect and which is substantially free of agglomerated intrinsic point defects, wherein the first axially symmetric region comprises a central axis or has a width of at least about 15 mm.
    Type: Grant
    Filed: April 9, 1998
    Date of Patent: February 20, 2001
    Assignee: MEMC Electronic Materials, Inc.
    Inventors: Robert A. Falster, Joseph C. Holzer, Marco Cornara, Daniela Gambaro, Massimiliano Olmo, Steve A. Markgraf, Paolo Mutti, Seamus A. McQuaid, Bayard K. Johnson
  • Patent number: 6190632
    Abstract: A system for producing ammonia by integrating blast furnace ironmaking with ammonia production wherein cryogenic rectification links the two systems enabling the production of ammonia synthesis gas from blast furnace gas for use in the ammonia production.
    Type: Grant
    Filed: February 25, 1999
    Date of Patent: February 20, 2001
    Assignee: Praxair Technology, Inc.
    Inventors: Minish Mahendra Shah, Raymond Francis Drnevich
  • Patent number: 6190633
    Abstract: Inexpensive spindle- or needle-like calcium carbonate giving useful properties for bulk, brightness, opacity, wire abrasion resistance and yield as a paper filler is provided by taking advantage of the causticization step. In a first step, a quick lime having a calcium carbonate content of 10% by weight or less is slaked with a liquor having a pH of 5.5 to 13.5 at a concentration of 20 to 60% to prepare a milk of lime. In a second step, causticization reaction takes place at a green liquor loading rate of 0.02 to 0.5 cc (green liquor)/min/g (quick lime) at a reaction temperature of 20 to 105° C. to afford spindle- or needle-like calcium carbonate.
    Type: Grant
    Filed: June 1, 1999
    Date of Patent: February 20, 2001
    Assignee: Nippon Paper Industries Co., Ltd.
    Inventors: Kazuto Takahashi, Kiyoshi Kanai, Yasunori Nanri, Yasuhiro Okamoto
  • Patent number: 6190634
    Abstract: A nanoscale carbide article consisting essentially of covalently bounded elements M1, M2, and C having the molar ratio M1:M2:C::1:y:x, wherein the article has an aspect ratio of between 10 and 1000 and has a shorter axis of between 1 and 40 nanometers.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: February 20, 2001
    Assignee: President and Fellows of Harvard College
    Inventors: Charles M. Lieber, Hongjie Dai
  • Patent number: 6190635
    Abstract: In order to remove the methanesulphonyl chloride entrained by the gaseous HCl by-product, an amount of water ranging from 0.01 to 20%, relative to the mass of HCl to be treated, is injected into the HCl gas flow and the temperature is lowered to a value below or equal to 15° C.
    Type: Grant
    Filed: July 30, 1998
    Date of Patent: February 20, 2001
    Assignee: Elf Atochem S.A.
    Inventors: Jean Ollivier, Rene Clair, Denise Molines, Marc Ferrigno
  • Patent number: 6190636
    Abstract: A novel method is described whereby chlorine and sodium sulfate waste by-products from chemical by-products are recycled to form useful chemicals. Sodium sulfate is first reacted to form a metal sulfate and sodium chloride. The sodium chloride may be used as a chemical feed in chlor-alkali plants. The metal sulfate is then reacted to form an ammonium sulfate or bisulfate which in turn is reacted with chlorine to form sulfuric acid. The sulfuric acid may be used a chemical feed in chlorine dioxide plants and in various other chemical processes.
    Type: Grant
    Filed: July 2, 1999
    Date of Patent: February 20, 2001
    Inventors: Mohammed N. I. Khan, M. Fazlul Hoq
  • Patent number: 6190637
    Abstract: The present invention provides a method for preparing [F-18]-fluoride ion which comprises the step of bringing [O-18]-enriched water containing [F-18]-fluoride ion formed by proton irradiation of [O-18]-enriched water into contact with a strongly acidic cation exchange resin to remove impurity cations, the step of then bringing the [O-18]-enriched water containing [F-18]-fluoride ion treated above into contact with a weakly basic anion exchange resin to make [F-18]-fluoride ion adsorbed to the resin and, along therewith, to recover the [O-18]-enriched water which has passed through the resin, and the step of eluting and collecting the [F-18]-fluoride ion adsorbed to the weakly basic anion exchange resin.
    Type: Grant
    Filed: March 11, 1999
    Date of Patent: February 20, 2001
    Assignee: Nihon Medi-Physics Co., Ltd.
    Inventors: Sento Ino, Masahiko Tamura, Osamu Itoh
  • Patent number: 6190638
    Abstract: Mixtures of synthesis mixtures of different alkalinity's produce small MFI crystals that are not spherical.
    Type: Grant
    Filed: October 19, 1998
    Date of Patent: February 20, 2001
    Assignee: Exxon Chemical Patents Inc.
    Inventors: Marc H. Anthonis, Antonie Jan Bons, Johannes P. Verduijn
  • Patent number: 6190639
    Abstract: Process for the preparation of a mesoporous, crystalline, acidic molecular sieve comprising the successive steps of (a) preparing an aqueous mixture comprising a silicon source, a fluorine source, and an organic template at a temperature in the range of at most 90° C. such that crystallization starts; (b) adjusting the pH of the solution to such value in the range of from about 5.0 to about 12.5 that a precipitate is formed; (c) recovering the precipitate; and (d) calcining the precipitate to obtain the mesoporous, crystalline, acidic molecular sieve, wherein an aluminum source is added in one or more of steps (a) and (b) and/or between steps (c) and (d) in such amount that after addition of all aluminum source the Si/Al atomic ratio is at least about 3.
    Type: Grant
    Filed: July 12, 1999
    Date of Patent: February 20, 2001
    Assignee: Shell Oil Company
    Inventors: Jean-Louis Guth, Laurent Georges Huve, Anne-Claude Voegtlin
  • Patent number: 6190640
    Abstract: The invention involves the therapeutic use of humanized antibodies, fragments, etc., which bind to the antigen A33. These antibody molecules are useful in the treatment of various neoplasias, including colon cancer. Various modes of administration, and doses are described.
    Type: Grant
    Filed: November 19, 1996
    Date of Patent: February 20, 2001
    Assignees: Ludwig Institute for Cancer Research, Sloan-Kettering Institute for Cancer Research
    Inventors: Sydney Welt, Gerd Ritter, Leonard Cohen, Clarence Williams, Jr., Elizabeth Carswell Richards, Mary John, Lloyd J. Old
  • Patent number: 6190641
    Abstract: The sensitivity and specificity of the optical modality can be enhanced by the use of highly absorbing dyes as contrast agents. Novel indocyanine dyes that absorb and emit light in the near infrared region of electromagnetic spectrum are disclosed. These dyes are useful for imaging, diagnosis and therapy of various diseased states. Particularly, the molecules of the invention are useful for optical diagnostic imaging and therapy, in endoscopic applications for the detection of tumors and other abnormalities, for localized therapy, for photoacoustic tumor imaging, detection and therapy, and for sonofluorescence tumor imaging, detection and therapy.
    Type: Grant
    Filed: January 18, 2000
    Date of Patent: February 20, 2001
    Assignee: Mallinckrodt Inc.
    Inventors: Samuel Achilefu, Raghavan Rajagopalan, Richard B. Dorshow, Joseph E. Bugaj
  • Patent number: 6190642
    Abstract: Irrigants to be used with vibratory scaling apparatus and lavage are provided. The irrigants of the invention are characterized in that they contain medicaments for the treatment of conditions in the mouth and have a viscosity and deliquescence adapted to substantially optimize the efficiency of the apparatus. The irrigants are formulated so that they have minimal stickiness on drying, minimal foaming and do not gum-up the apparatus in which they are used. Also provided is a method for treating dental diseases comprising applying the irrigants of the invention through a vibratory scaring apparatus to substantially optimize the efficiency of said apparatus and to substantially optimize destruction and removal of infectious bacteria using said apparatus and the removal or inactivation of endotoxins derived from bacteria or the host.
    Type: Grant
    Filed: October 18, 1994
    Date of Patent: February 20, 2001
    Assignee: Dentsply Research & Development Corp.
    Inventors: Emery W. Dougherty, John B. Heyde
  • Patent number: 6190643
    Abstract: The invention relates to a method for reducing the viability of detrimental oral microorganisms in an individual, said method comprising subjecting the individual's oral cavity to a bioactive glass, the average particle size of which is less than 100 &mgr;m. Furthermore, this invention concerns a method for the prevention of dental caries and/or gingivitis in an individual, said caries being caused by a cariogenic bacteria; or for prevention or treatment of periapical infections. Further the invention relates to a method for the whitening and/or mechanical cleaning of an individual'teeth.
    Type: Grant
    Filed: March 2, 1999
    Date of Patent: February 20, 2001
    Inventors: Patricia Stoor, Eva Söderling, Antti Yli-Urpo, Jukka Salonen
  • Patent number: 6190644
    Abstract: Disclosed are oral compositions comprising one or more linear polyphosphates having an average chain length of about 4 or more, sodium monofluorophosphate, a buffering agent, an abrasive polishing material containing less than 23% calcium, and one or more aqueous carriers, wherein the oral composition has a total water content of from about 5% to about 20%.
    Type: Grant
    Filed: November 21, 1996
    Date of Patent: February 20, 2001
    Assignee: The Procter & Gamble Company
    Inventors: Stephen Francis McClanahan, Donald James White, Jr., Edward Russell Cox
  • Patent number: 6190645
    Abstract: The present invention is a sunscreen composition that protects the scalp and hair from the sun's rays. The composition contains at least one sunscreen agent in combination with a cinnamido alkyl amine cationic quaternary salt. In addition, a method for protecting the scalp and hair by applying an effective amount of the composition is provided.
    Type: Grant
    Filed: July 15, 1999
    Date of Patent: February 20, 2001
    Assignee: Playtex Products, Inc.
    Inventors: James SaNogueira, Thomas Russo
  • Patent number: 6190646
    Abstract: A microemulsion is prepared containing: a mixture of (1) nitrogenous compounds, (2) from 10-5% by weight of an alkyl or alkenyl phosphoric ester surfactant, the alkyl and alkenyl groups of which contain less than 12 carbon atoms per group and the ester surfactant containing from 1 to 10 alkoxy radicals, (3) from 3 to 20% by weight of at least one cosurfactant, (4) a vegetable oil, an animal oil or a fatty acid and (5) a plasticizer. The microemulsion having a viscosity at 5° C. less than or equal to 200 mPa·sec and is stable at a temperature of −10° C. to +50° C. Further, the microemulsion is useful as a biodegradation accelerator.
    Type: Grant
    Filed: September 15, 1999
    Date of Patent: February 20, 2001
    Assignee: Elf Aquitaine
    Inventors: Jacques Tellier, Anne Basseres, Pascal Brochette, Alexandre Espert
  • Patent number: 6190647
    Abstract: The hair treatment composition for increasing the formability and luster of hair contains from 0.01 to 10 percent by weight of a copolymer formed from at least one ethylenic unsaturated monomer of the formula (I): CH2═CR1R2  (I), wherein R1 is A—(CH2CH2O)x—R3 or COOH group and A is C(═O)O, C(═O)NH or CH2O, x is a number from 1 to 100, R3 is a C8- to C30-alkyl group, R2 is H, a C1- to C30-alkyl group or a CH2—R1 group, with the proviso that at least one of the groups, R1 and R2, contain the A—(CH2CH2O)x—R3 group; and from at least one ethylenic unsaturated monomer of the formula (II): CH2═CR4COOR5  (II), wherein R4 and R5 are, independently of each other, H or an alkyl group with 1 to 30 carbon atoms; from 0.01 to 50 percent by weight of a polyethylene glycol with a molecular weight over 500 g/mol and from 0.01 to 20 percent by weight of a nonionic surfactant having an HLB-value under 20.
    Type: Grant
    Filed: July 10, 1998
    Date of Patent: February 20, 2001
    Assignee: Wella Aktiengesellschaft
    Inventors: Thomas Karlen, Daniel Chambettaz, Karin Steinbrecht
  • Patent number: 6190648
    Abstract: In a hair cosmetic containing titanium-dioxide-coated mica, titanium-dioxide-coated mica with particle diameters of 20 &mgr;m or larger is used in a proportion not more than 10% by volume in the total volume of the titanium-dioxide-coated mica so that, when applied to hair, it may not impart an unnaturally glittering impression to the hair. To improve re-dispersibility of such a hair cosmetic, a carboxyvinyl polymer and an amphoteric macromolecule may be used in combination.
    Type: Grant
    Filed: June 19, 1998
    Date of Patent: February 20, 2001
    Assignee: Kao Corporation
    Inventors: Emiko Kouzu, Takashi Itou, Atsushi Uzu, Tadashi Nomura, Michiko Asami, Aya Hirano, Yoshiaki Itou
  • Patent number: 6190649
    Abstract: The present invention relates to a method for sequestering bile acids in a patient and to particular polymers for use in the method. The invention further relates to a method for reducing blood cholesterol, treating atherosclerosis, treating hypercholesterolemia and/or reducing plasma lipid content of a mammal. The methods of the invention comprise orally administering to the patient a therapeutically effective amount of a polymer characterized by a polyether backbone and amino or ammonium groups pendant therefrom. The amino nitrogen atoms can be substituted by one or more substituents independently selected from among substituted and unsubstituted, normal, branched and cyclic alkyl groups, and aryl groups. When the polymer comprises pendant ammonium or quaternary ammonium groups, the polymer will be associated with a pharmaceutically acceptable anion.
    Type: Grant
    Filed: April 23, 1999
    Date of Patent: February 20, 2001
    Assignee: GelTex Pharmaceuticals, Inc.
    Inventors: Stephen Randall Holmes-Farley, Chad Cori Huval
  • Patent number: 6190650
    Abstract: An antiviral compound comprises a dendrimer such as a polyamidoamine or polyly sine dendrimer having a plurality of terminal groups, wherein at least one of the terminal groups has an anionic- or cationic-containing moiety bonded thereto, particularly a sulfonic acid-containing, carboxylic acid-containing or trimethylammonium-containing moiety or the like.
    Type: Grant
    Filed: April 28, 1997
    Date of Patent: February 20, 2001
    Assignee: Biomolecular Research Institute Ltd.
    Inventors: Barry Ross Matthews, George Holan
  • Patent number: 6190651
    Abstract: A solution for preserving contact lenses for shipping, which comprises a polyvinyl pyrrolidone having a weight average molecular weight of from 500 to 200,000, and which contains no surfactant.
    Type: Grant
    Filed: July 15, 1999
    Date of Patent: February 20, 2001
    Assignee: Menicon Co., Ltd.
    Inventors: Kazuhiko Nakada, Yutaka Matano
  • Patent number: 6190652
    Abstract: Compositions of cis-jasmone were found to effectively attract adult Lepidoptera. The cis-jasmone may be used alone or in combination with one or more other volatiles of the Japanese honeysuckle flower, particularly linalool and/or phenylacetaldehyde. By attracting the adult Lepidoptera to attracticidal baits and/or field traps, the attractants are useful for the control and monitoring of these agricultural pests.
    Type: Grant
    Filed: July 28, 1997
    Date of Patent: February 20, 2001
    Assignee: The United States of America as represented by the Secretary of Agriculture
    Inventors: Sammy D. Pair, Robert J. Horvat
  • Patent number: 6190653
    Abstract: Compositions and lures are described which provide synthetic chemical attractants which function as highly effective attractants for male and female moths, primarily moths of the family Noctuidae. In one aspect, the attractants provide an effective attractant amount of vapor of 3-methyl-1-butanol, 3-methyl-1-pentanol or mixtures thereof. In another aspect, the attractants provide vapor blends of acetic acid and one or more compounds selected from the group consisting of 3-methyl-1-butanol, 3-methyl-2-butanol, and 3-methyl-1-pentanol. By attracting male and female moths to traps or baits, the chemical attractants provide a means for detecting, surveying, monitoring, and controlling the moths.
    Type: Grant
    Filed: September 18, 1998
    Date of Patent: February 20, 2001
    Assignee: The United States of America as represented by the Secretary of Agriculture
    Inventors: Peter J. Landolt, Robert R. Heath
  • Patent number: 6190654
    Abstract: A light reflecting fish attractant comprised of mica flakes is provided. The mica flakes are cast into the water where they slowly sink to the bottom. During their descent, they cascade wildly with the eddies and currents of the water. The light which filters down into the water is reflected off the mica, causing a glittering or flashing. This reflected light attracts fish into the area. The mica flakes are chosen to be sized in the range of 0.001 inch to about 3.0 inch in length, in the range of 0.001 inch to about 3 inch in width and about any size larger than 0.001 inch in thickness. This size range permits the mica flakes to approximate the common sizes of fish scales. The mica flakes giving the appearance of fish scales attracts predator fish to the area where the mica flakes are introduced. After introducing the mica flakes to the water, the sportsman would introduce the fishing line to the area where the flakes have been placed.
    Type: Grant
    Filed: March 16, 1999
    Date of Patent: February 20, 2001
    Inventor: Ken Hukee
  • Patent number: 6190655
    Abstract: Ligands for flt3 receptors capable of transducing self-renewal signals to regulate the growth, proliferation or differentiation of progenitor cells and stem cells are disclosed. The invention is directed to flt3-L as an isolated protein, the DNA encoding the flt3-L, host cells transfected with cDNAs encoding flt3-L, compositions comprising flt3-L, methods of improving gene transfer to a mammal using flt3-L, and methods of improving transplantations using flt3-L. Flt3-L finds use in treating patients with anemia, AIDS and various cancers.
    Type: Grant
    Filed: September 25, 1998
    Date of Patent: February 20, 2001
    Assignee: Immunex Corporation
    Inventors: Stewart D. Lyman, M. Patricia Beckmann
  • Patent number: 6190656
    Abstract: A method for activating a mammalian immune system entails a series of IL-2 administrations that are effected intermittently over an extended period. Each administration of IL-2 is sufficient to allow spontaneous DNA synthesis in peripheral blood or lymph node cells of the patient to increase and peak, and each subsequent administration follows the preceding administration in the series by a period of time that is sufficient to allow IL-2 receptor expression in peripheral or lymph node blood of the patient to increase, peak and then decrease to 50% of peak value. This intermittent IL-2 therapy can be combined with another therapy which targets a specific disease state, such as an anti-retroviral therapy comprising, for example, the administration of AZT, ddI or interferon alpha. In addition, IL-2 administration can be employed to facilitate in situ transduction of T cells in the context of gene therapy.
    Type: Grant
    Filed: September 2, 1997
    Date of Patent: February 20, 2001
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: H. Clifford Lane, Joseph A. Kovacs, Anthony S. Fauci
  • Patent number: 6190657
    Abstract: The present invention is directed to the isolation and use of super-infective, tumor-specific vectors that are strains of parasites including, but not limited to bacteria, fungi and protists. In certain embodiments the parasites include, but are not limited to, the bacterium Salmonella spp., such as Salmonella typhimurium, the bacterium Mycobacterium avium and the protozoan Leishmania amazonensis. In other embodiments, the present invention is concerned with the isolation of super-infective, tumor-specific, suicide gene-containing strains of parasites for use in treatment of solid tumors.
    Type: Grant
    Filed: June 4, 1996
    Date of Patent: February 20, 2001
    Assignee: Yale University
    Inventors: John M. Pawelek, David Bermudes, Kenneth Brooks Low
  • Patent number: 6190658
    Abstract: This invention discloses a genetically modified manganese superoxide dismutase nucleic acid molecule and protein. Also disclosed are recombinant molecules, recombinant cells, therapeutic compositions and methods of using the modified manganese superoxide dismutase to treat oxidative damage.
    Type: Grant
    Filed: May 8, 1998
    Date of Patent: February 20, 2001
    Assignee: Webb-Waring Institute for Biomedical Research
    Inventors: Joe M. McCord, Bifeng Gao, Sonia C. Flores
  • Patent number: 6190659
    Abstract: The present invention describes a novel polypeptide, and methods of its use in effective thrombolytic therapy in the treatment of coronary and pulmonary thrombosis. Its use is also disclosed in vaccines to abrogate a streptococcal infection. Pharmaceutical compositions containing the novel polypeptide are included. One particular form of the novel polypeptide is streptococcal surface enolase (SEN), a specific binding protein for human plasmin and/or human plasminogen on group A streptococci that displays classical &agr;-enolase activity, i.e., it can catalyze the dehydration of D-glycerate-2-phosphate to phosphoenolpyruvate. In addition, SEN impedes the inhibition of the fibrinolytic activity of plasmin by &agr;2-antiplasmin and can bind plasminogen without preventing streptokinase from cleaving this plasmin precursor.
    Type: Grant
    Filed: September 17, 1996
    Date of Patent: February 20, 2001
    Assignee: The Rockefeller University
    Inventors: Vijaykumar Pancholi, Vincent A. Fischetti
  • Patent number: 6190660
    Abstract: A monoclonal antibody, or fragments thereof, having binding specificity for both endoglin expressed on human vascular endothelial cells and on murine endothelial cells. Antiangiogenic therapy in mammals can be effected by administering to the mammalian host a therapeutically effective amount of an anti-endoglin monoclonal antibody, or fragment thereof, either unconjugated or conjugated to at least one angiogenesis inhibitor or antitumor agent. The composition is useful for treating tumor and angiogenesis-associated diseases.
    Type: Grant
    Filed: February 3, 2000
    Date of Patent: February 20, 2001
    Assignee: Health Research, Inc.
    Inventor: Ben K. Seon
  • Patent number: 6190661
    Abstract: Disclosed are methods and compositions for identifying, monitoring and treating premalignant and malignant conditions in a human subject. The present invention further discloses methods and compositions for determining cells undergoing apoptosis, and for increasing the efficacy of a cancer therapy. The methods involve the use of apurinic/apyrimidinic endonuclease (APE), independently, as a marker for (pre)malignant conditions and for apoptosis. Also described are polyclonal antibody preparations for use in methods for detecting APE and methods for modulating expression susceptibility of cells to apoptosis.
    Type: Grant
    Filed: June 18, 1999
    Date of Patent: February 20, 2001
    Assignee: Advanced Research & Technology Institute
    Inventors: Mark R. Kelley, John Duquid, John Eble
  • Patent number: 6190662
    Abstract: Methods for obtaining surface expression of a desired protein or polypeptide in Gram-positive host organisms are provided. In addition, vectors useful in such methods as well as Gram-positive host organisms transformed with such vectors are disclosed.
    Type: Grant
    Filed: March 6, 1998
    Date of Patent: February 20, 2001
    Assignee: Vlaams Interuniversitair Instituut voor Biotechnologie (VIB) vzw
    Inventors: Lothar Steidler, Erik Remaut, Jeremy Mark Wells
  • Patent number: 6190663
    Abstract: The present invention provides nucleic acid and amino acid sequences that identify and encode a novel human map kinase homolog (SMAP) expressed in cells of the human stomach. The present invention also provides for PCR oligomers or hybridization probes for the detection of nucleotide sequences encoding SMAP or SMAP-like molecules, antisense molecules to the nucleotide sequences which encode SMAP, diagnostic tests based on SMAP encoding nucleic acid molecules, genetically engineered expression vectors and host cells for the production of purified SMAP, antibodies capable of binding specifically to SMAP, and agonists and inhibitors with specific binding activity for the polypeptide SMAP.
    Type: Grant
    Filed: July 28, 1998
    Date of Patent: February 20, 2001
    Assignee: Incyte Genomics, Inc.
    Inventors: Phillip R. Hawkins, Janice Au-Young, Karl J. Guegler, Craig G. Wilde
  • Patent number: 6190664
    Abstract: A cosmetic skin-care composition containing as the active principle a depigmentationally active combination of (a) an acidic mixture including (i) at least one &agr;-hydroxylated acid or a derivative thereof, with the exception of ascorbic acid, and (ii) at least one compound selected from the group which consists of kojic acid, caffeic acid, azelaic acid, aminobutyric acid, fusaric acid, 5-hydroxy 2-hydroxymethyl-&ggr;-pyridone, and derivatives thereof, and (b) at least one active component of a plant extract from at least one plant selected from white mulberry, liquorice, skull cap, grapefruit, birch, heather, strawberry tree, bearberry, lemon, lettuce, oarweed, cucumber, ginseng, hop, sweet corn, feverfew, sage, soya, elder, spirulina, lime, ferocious aloe, yukinoshita, bloodwort, hoelen, wood rose, &agr;-orizanol, burnet, ginkgo biloba, tanlex VB and Eclipsa alba, with the proviso that when the composition contains kojic acid and a liquorice extract, it contains at least one other plant extract component.
    Type: Grant
    Filed: February 6, 1998
    Date of Patent: February 20, 2001
    Assignee: C 3 D
    Inventor: Christian Dampeirou
  • Patent number: 6190665
    Abstract: Disclosed is a calcium channel antagonist effective as a single substance for attaining dual purposes of inhibiting secretion of parathyroid hormones and of promoting absorption and utilization of calcium in human body as well as a process for preparing the calcium channel antagonist. According to the present invention. the calcium channel antagonist is prepared by baking a calciferous material of plant origin at a temperature of 500-1000° C. under reduce pressure or vacuum and extracting the baked material with and acidic substance. The calcium channel antagonist may be incorporated with a conventional calcium preparations to enhance bioavailability of calcium. Further, the calcium channel antagonist of the present invention may be processed to calcium preparations in the form of porous granules.
    Type: Grant
    Filed: May 19, 1998
    Date of Patent: February 20, 2001
    Assignee: Fujix Inc.
    Inventors: Ranko Inoue, Takeshi Inoue, Takuo Fujita, Yoshihisa Kudoh, Seiichi Yamagiwa
  • Patent number: 6190666
    Abstract: The disclosure describes recombinant alphavirus RNA molecules and expression of heterologous proteins therefrom in animal cells. Recombinant alphaviruses of the present invention, when made to express an antigenic protein, can be administered as vaccines.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: February 20, 2001
    Assignee: Bioption
    Inventors: Henrik Garoff, Peter Liljeström
  • Patent number: 6190667
    Abstract: This invention relates to methods of screening molecules capable of inhibiting the survival of Helicobacter pylori in vivo by specifically inhibiting the activity of UreI, to the molecules identified by these methods, and to the use of these molecules to treat or prevent H. pylori infection.
    Type: Grant
    Filed: June 30, 1998
    Date of Patent: February 20, 2001
    Assignee: Institut Pasteur
    Inventors: Hilde De Reuse, Stéphane Skouloubris, Valérie Cussac, Agnès Labigne
  • Patent number: 6190668
    Abstract: An isolated and purified non-denatured transferrin receptor protein of a Moraxella strain, particularly M. catarrhalis, has an apparent molecular mass of about 80 to about 90 kDa, as determined by SDS-PAGE. The transferrin receptor protein or a fragment analog thereof is useful in diagnostic applications and immunogenic compositions, particularly for in vivo administration to a host to confer protection against disease caused by a strain of Moraxella. The transferrin receptor protein is isolated from strains of Moraxella catarrhalis by a procedure including extraction of agent soluble proteins of a cell mass produced by cultivating the strain under iron-starved conditions. The transferrin receptor protein is selectively solubilized from the extracted cell mass and purified.
    Type: Grant
    Filed: July 30, 1998
    Date of Patent: February 20, 2001
    Assignee: Connaught Laboratories Limited
    Inventors: Yan-Ping Yang, Lisa E. Myers, Robin E. Harkness, Michel H. Klein
  • Patent number: 6190669
    Abstract: Attenuated Salmonella mutants which constitutively express the Vi antigen are disclosed, as well as vaccines against typhoid fever containing the same, live vector vaccines containing the same, and DNA-mediated vaccines containing the same.
    Type: Grant
    Filed: May 13, 1998
    Date of Patent: February 20, 2001
    Assignee: University of Maryland, Baltimore
    Inventors: Fernando R. Noriega, Marcelo B. Sztein, Myron M. Levine
  • Patent number: 6190670
    Abstract: The invention provides a method of enhancing an immune response to an immunogen in an animal. The method comprises administering to the animal an effective amount of the immunogen and an effective amount of a modified C-reactive protein (mCRP) or a mutant-mCRP. The invention also provides a vaccine and a method of producing this vaccine. The vaccine comprises an immunogen and an mCRP or a mutant-mCRP in a pharmaceutically-acceptable vehicle. The invention further provides a kit for immunizing an animal to an immunogen comprising (1) a container holding the immunogen and a container holding an mCRP or a mutant-mCRP or (2) a container holding the immunogen and an mCRP or a mutant-mCRP. The invention also provides a method of elicing an immune response to a hapten in an animal. The method comprises administering to the animal an effective amount of the hapten in association with an an effective amount of an mCRP or a mutant-mCRP. The invention further provides a vaccine and a method of producing this vaccine.
    Type: Grant
    Filed: August 18, 1999
    Date of Patent: February 20, 2001
    Assignee: Immtech International Inc.
    Inventors: Lawrence A. Potempa, James A. Radosevich
  • Patent number: 6190671
    Abstract: A drug containing, in particular, fractions of the envelopes of bacteria of genera Beggiatoa and Vitreoscilla. The drug is particularly useful for treating ear, nose and throat infections or bronchopulmonary infections.
    Type: Grant
    Filed: June 5, 1995
    Date of Patent: February 20, 2001
    Assignee: L'Oreal
    Inventors: Lucien Aubert, Richard Martin