Abstract: A method for producing a T cell having tolerance to an allergen or antigen which method comprises incubating the T cell with an antigen presenting cell (APC) in the presence of (i) a composition capable of upregulating expression of an endogenous Notch ligand in the APC and (ii) the allergen or antigen is provided.

Abstract: A novel oral pharmaceutical composition in the form of a stable flocculated suspension in water is described as comprising: megestrol acetate; at least one compound selected from the group consisting of polyethylene glycol, propylene glycol, glycerol, and sorbitol; and a surfactant, wherein polysorbate and polyethylene glycol are not simultaneously present.

Abstract: Mammalian hair growth is reduced by applying to the skin a composition including an inhibitor of an enzyme involved in arachidonic acid metabolism.

Abstract: Cosmetic compositions, such as solid aqueous cosmetic compositions, such as solid aqueous gels, comprising, in a cosmetically acceptable medium, at least one polyvinyl alcohol, wherein said compositions have a stress measurement ranging from 200 to 10,000 Pascals. Processes for preparing such compositions comprising (1) cooling a homogeneous aqueous solution of at least one polyvinyl alcohol to a temperature of less than or equal to −5° C., and (2) heating said solution to a temperature of 20-25° C.

Abstract: The invention is a process for producing a dairy-based cosmetic product, which comprises preparing a premix by mixing whey powder with a liquid carrier, heating the resulting mixture, then cooling the heated mixture, adding a preservative and imidazolidinyl urea to the mixture prior to or after heating to complete preparation of the premix, and formulating a cosmetic product from the premix by adding EDTA or an EDTA salt and citric acid to the premix, and completing the formulation, the cosmetic product containing at least about 3% wt. whey solids basis.

Abstract: A covering for soft furnishing is impregnated with an insecticide, such as permethrin. The concentration of permethrin is sufficient to kill house dust mites and deter larger insects such as fleas and ticks. The insecticide is released from the covering over an operational period so as to encourage the absorption of the insecticide into surrounding soft furnishings. The covering is manufactured from machined fabric, such as knitted voile, having interstices sufficiently small to reduce the rate of insecticide release over the operational period.

Abstract: A device for dispensing a skin treating agent on an appendage and its method of manufacture. The device having a first side with an inner surface and an outer surface, a second side with an inner surface and an outer surface, the first side and second side connected at an outer seal with the inner surfaces facing one another and forming a chamber for receiving and enclosing the appendage. The first and second sides having a perforated area which when torn apart creates an opening where the appendage is inserted into the chamber and a quantity of skin treating agent distributed in discrete areas on at least one of the inner surfaces of the chamber. A securing member enables the device to be secured to the appendage.

Abstract: A moisturizing and therapeutic glove is disclosed which includes a thin layer of Aloe Vera coated evenly and uniformly on an inside surface of the glove. Aloe Vera is attached to the surface through a dehydration process achieved with a controlled drying method. Aloe Vera soothes hand during the wearing of the glove.

Abstract: Pharmaceutical composition comprising (S)-N-ethyl-3-[1-dimethylamino)ethyl]-N-methyl-phenyl-carbamate in free base or acid addition salt form and an anti-oxidant. Said pharmaceutical compositions may be delivered to a patient using a transdermal delivery device.

Abstract: Cationic cytofectins and liposomes comprising the same are disclosed which are especially useful for delivering exogenous compounds into cells in vitro and in vivo. The liposomes may comprise (a) a neutral lipid such as dioleoylphosphatidyl-ethanolamine (DOPE) or similar lipid-like compounds such as 1,2-dioleoyl-oxiphosphatidylethanolamine or other lipid-like structures and (b) one or more of the cationic cytofectins provided herein. The invention provides transfection kits and methods for delivery of exogenous compounds into cells.

Abstract: The effective introduction of foreign genes and other biologically active molecules into targeted mammalian cells is a challenge still facing those skilled in the art. Gene therapy, for example, requires successful transfection of target cells in a patient. The present invention relates to novel micellar complexes of cationic amphiphilic compounds that facilitate delivery of biologically active molecules to the targeted cells of a mammal. The novel micellar complexes are comprised of a cationic amphiphile, a biologically active molecule, a derivative of polyethylene glycol (PEG), and optionally, a co-lipid. A further aspect of the invention is the use of targeting agents in any of the methods that effectuate the delivery of biologically active molecules into the cells of mammals. A targeting agent is usually any molecule, peptide sequence, or large protein that preferentially targets or binds to specific mammalian cells.

Abstract: Therapeutic compounds and methods for inhibiting amyloid deposition in a subject, whatever its clinical setting, are described. Amyloid deposition is inhibited by the administration to a subject of an effective amount of a therapeutic compound comprising an anionic group and a carrier molecule, or a pharmaceutically acceptable salt thereof, such that an interaction between an amnyloidogenic protein and a basement membrane constituent is inhibited. Preferred anionic groups are sulfonates and sulfates.

Abstract: A method of decreasing atherosclerosis and its complications including but not limited to myocardial infarction, stroke, and peripheral vascular disease comprising administering to a human or animal an amount of dutasteride sufficient to decrease atherosclerosis and its complications.

Abstract: The present invention provides an osmotic device containing controlled release venlafaxine in the core in combination with an anti-psychotic agent in a rapid release external coat. A wide range of anti-psychotic agents can be used in this device. Particular embodiments of the invention provide osmotic devices having predetermined release profiles. One embodiment of the osmotic device includes an external coat that has been spray-coated rather compression-coated onto the device. The device with spray-coated external core is smaller and easier to swallow than the similar device having a compression-coated external coat. The device is useful for the treatment of depression, anxiety or psychosis related disorders.

Abstract: An antibiotic product is comprised of at least three dosages forms, each of which has a different release profile, with the Cmax for the antibiotic product being reached in less than about twelve hours. In one embodiment, there is an immediate release dosage form, as well as two or more delayed release dosage forms, with each of the dosage forms having a different release profile, wherein each reaches a Cmax at different times.

Abstract: Pharmaceutical compositions that enable the release of a physiologically active substance over a prolonged period of time following administration to a patient are described. The pharmaceutical compositions are provided by encapsulation of a physiologically active substance into a matrix comprising biodegradable polymers and lipids. The rate of release of the physiologically active substance from the pharmaceutical composition is controlled by varying the ratio of the polymer to the lipid. The compositions can be stored in an aqueous suspension or as a solid dosage form. The physiologically active substances include small molecules, peptides, proteins, nucleic acids and vaccines. The biodegradable polymers include homopolymers, or random or block copolymers. The lipids include phospholipids, cholesterol and glycerides.

Abstract: Solid particulate dispersions of pharmaceutical agents in a matrix of a water-soluble polymer exhibiting good aqueous dissolution and enhanced bioavailability.

Abstract: The invention features articles for delivery of a biologically active substance, methods for making such articles, and methods for treating an animal using the articles.

Abstract: The present invention relates to nutritive compositions containing whey, FOS, and bovine or caprine colostrum for the creation and maintenance of a heathy intestinal flora and for the enhancement of the immune system.

Abstract: Methods and materials for tissue reconstruction, repair, and/or augmentation are disclosed. The invention provides isolated bladder submucosa for use in tissue reconstruction. The methods of the invention include the use of isolated bladder submucosa for repair, reconstruction, and/or augmentation of bladder and other organs and tissues.

Abstract: A method for stabilizing dilute solutions of 3-isothiazolone compounds against the formation of unwanted brown precipitate in the presence of low levels of copper, by the addition of 2 to 50% of selected water-soluble organic solvents, is disclosed. Preferably, the aqueous solutions are substantially free of metal nitrate, metal nitrite and magnesium salt stabilizers.

Abstract: Improved methods of administering a synthetic plasma-like solution to a subject, as well as systems and kits for practicing the same, are provided by the subject invention. In the subject methods, the CO2 level of the subject, particularly the CO2 level of at least one of the blood and brain of the subject, is reduced prior to administration of the synthetic plasma-like solution. The subject methods find use in a variety of applications where synthetic plasma-like solutions are employed, including the treatment of hypovolemia, hyphemia, and surgical procedures in which at least a portion of a subject's blood is replaced with a synthetic plasma-like solution and provide for a number of improvements, including a reduced risk of acidosis/acidemia and complications associated therewith.

Abstract: Nutritional compositions comprising aloe vera, hydrolyzed collagen, garcinia cambogia, chromium polynicotinate, chromium picolinate, chromium cruciferate, conjugated linoleic acid, fiber and natural amino acids are disclosed. Nutritional compositions comprising aloe vera, hydrolyzed collagen, garcinia cambogia tea, fenugreek tea, coleus forskohli tea, chromium polynicotinate, chromium picolinate, chromium cruciferate, conjugated linoleic acid, fiber and natural amino acids are also disclosed. Methods for preparing and using these compositions are additionally provided.

Abstract: The machine of the present invention is a means for manufacturing thermoplastic tubes from hollow thermoplastic sleeves by a variety of different manufacturing processes. The machine is a single apparatus having an indexing table with a plurality of mandrels for holding hollow thermoplastic sleeves for the purpose of transporting the same around a closed manufacturing path. The manufacturing path of the machine of the present invention is a series of stations which are mechanical devices for carrying out the manufacturing steps necessary to produce tubes from thermoplastic blank sleeves. The stations of the manufacturing path are modular so that they may be removed, added or rearranged; may be optionally connected to a process logic controller and may optionally have sensors for information feedback to the PLC device.

Abstract: A mold clamping apparatusm for an injection molding machine comprises a stationary platen fixedly holding the stationary mold, a movable platen fixedly holding the movable mold and disposed opposite to the stationary platen, tie bars for guiding the movable platen for movement toward and away from the stationary platen, a movable platen driving means for moving the movable platen along the tie bars to close and open the mold, a movable platen fixing means for fixing the movable platen to the tie bars at a set position immediately before a position where the movable mold is joined to the stationary mold, and a clamping force applying means comprising sealed hydraulic cylinder actuators capable of converting energy of a hydraulic fluid into an intensified mold clamping force and of applying the intensified mold clamping force to the stationary platens.

Abstract: A method for feeding a pet a balanced meal or supplement. For a dog, the meal includes a main course having a high protein content, a side dish having a high carbohydrate content and a dog treat preferably in the traditional shape of a bone or biscuit which the dog has been preconditioned to perceive as a reward. The meal is provided in a tray having a removable cover, the tray being divided into separate compartments in which the main course, side dish and treat are placed. According to this inventive method, the dog receives a well-balanced and enjoyable meal or supplement.

Abstract: A process for manufacturing black leaf tea that looks and feels like orthodox processed tea but has the liquor characteristics of a fuller fermented CTC processed tea. The process involves withering a first supply of freshly plucked tea leaves, macerating the withered leaves, allowing the macerated withered leaves to ferment to produce macerated dhool, withering a second supply of freshly plucked tea leaves, mixing the macerated dhool obtained from the first supply of leaves with the withered leaves obtained from the second supply of leaves, rolling the mixture, allowing the rolled mixture to ferment, and drying the fermented mixture to yield black leaf tea.

Abstract: A beverage filter cartridge comprises an outer container with an access opening. A filter element is received in and configured and arranged to subdivide the interior of the container into first and second chambers. A beverage medium is stored in the first chamber. A lid closes the access opening. The lid has a first section overlying the first chamber and a second section overlying the second chamber. The first section of the lid is yieldably piercable to accommodate an inflow of liquid into the first chamber for infusion with the beverage medium to produce a beverage. The filter element is permeable to accommodate a flow of the beverage from the first chamber into the second chamber, and the second section of the lid is yieldably piercable to accommodate an outflow of the beverage from the second chamber to the exterior of the cartridge.

Abstract: The present invention relates to the system, apparatus, and method for controllably mixing a concentrate with a dilution substance using closed-loop feedback in order to improve the resultant substance. The present invention discloses a system, apparatus and method for sensing the conductivity of a diluted substance to provide feedback information for adjusting dispensing of a concentrate used to produce the resultant or diluted substance. The present invention also includes a system for dispensing beverages using the conductivity sensor such that the system controllably adjusts the dispensing of concentrate to maintain the resultant beverage within a desired concentration range based on conductivity sensing. The present invention also includes the method for sensing the conductivity of the resultant beverage and adjusting the dispensing of concentrate in response to the conductivity of the resultant beverage.

Abstract: The object of the present invention is to provide a method by which a great amount of fat and oil can be added continuously to porous feed.

Abstract: A peeling apparatus includes a set of abrasive rollers, at least one roller drive motor, a feeder for controllably feeding fruit or vegetables adjacent the abrasive rollers, at least one sensor associated with at least one roller drive motor for sensing a load thereon, and a controller for controlling the feeder based upon a sensed load. The controller may increase the feed rate based upon an increase in sensed load, and decrease the feed rate of the auger based upon a decrease in sensed load. The at least one roller drive motor may be a hydraulic or electric motor.

Abstract: In a method for controlling the mixing of dough ingredients in a mixer, dough ingredients are mixed. The amount of power supplied to the mixer is measured in specified time intervals. Data relating to the amount of power supplied are stored. Based on the stored data, a decline in the amount of power supplied to the mixer is identified and the mixer mixes the dough ingredients for a predetermined period of time after the decline is identified. A mixer of the present invention includes a mixing device, a motor coupled to the mixing device, a power source coupled to the motor, and a mixing-time controller.

Abstract: A process for the production of a frozen food product comprising AFP, wherein the conditions are chosen such that the ice-crystals in the product have an aspect ratio of from 1.9 to 3.

Abstract: A block former for the production of blocks of cheese, comprising an upright drainage column with a feed opening for curd particles at the upper end, a closed casing and a perforated inner tube. There is an annular space between the casing and the inner tube and a cutting-off device at the lower end for cutting off blocks of cheese. A discharge device is provided for discharging a cut-off block of cheese after a block forming cycle. A vacuum device is also provided for filling under reduced pressure the inner tube with curd particles via the feed opening and for creating a vacuum in the annular space. The column is divided into an upper and a lower part in such a manner that different pressures can prevail simultaneously in the upper and the lower part during any moment of the cycle.

Abstract: By this invention, low calorie fat compositions comprising the use of acylated glycerides are provided. Of particular interest is the use of triglyceride compositions having a at least one acylated fatty acid. Preferably, the acylated fatty acid has a melting temperature above 40° C. The acylated glyceride compositions find use as low calorie fat ingredients in food compositions. The low calorie fat compositions of the present invention demonstrate a caloric value of less than 6.5 kcal/g. Such low calorie fat compositions find use in the preparation of food compositions wherein at least a portion of the fat ingredients have been replaced with a acylated glyceride compositions of the present invention.

Abstract: A novel encapsulated product is provided and includes: at least one active ingredient; at least one compressible material; and at least one tableting material; wherein the encapsulated product is in the form of a caplet having a diameter of from about 1 millimeter to about 7 millimeters and a length from about 1 millimeter to about 7 millimeters. A method for preparing the encapsulated product is also provided. The encapsulated product may be incorporated into a food item, a soft confectionery product, a hard confectionery product, a jelly gum confectionery product, and a dry beverage or chewing gum product.

Abstract: A luminescent nanophase binder is provided for use in UV and VUV applications. The binder promotes adherence of phosphor coatings to lamp envelopes and emits visible light under UV and VUV excitation. In a preferred embodiment, the binder comprises SiO2 nanoparticles doped with terbium or terbium and yttrium. Preferably, the nanoparticles have a particle size of less than 50 nm.

Abstract: Removing the electrical field from the internal volume of high-voltage structures; e.g., bushings, connectors, capacitors, and cables. The electrical field is removed from inherently weak regions of the interconnect, such as between the center conductor and the solid dielectric, and places it in the primary insulation. This is accomplished by providing a conductive surface on the inside surface of the principal solid dielectric insulator surrounding the center conductor and connects the center conductor to this conductive surface. The advantage of removing the electric fields from the weaker dielectric region to a stronger area improves reliability, increases component life and operating levels, reduces noise and losses, and allows for a smaller compact design. This electric field control approach is currently possible on many existing products at a modest cost. Several techniques are available to provide the level of electric field control needed.

Abstract: A process is disclosed which utilizes ink-jet printing of optical polymeric fluids to produce microlenses on a substrate having an axial gradient index of refraction. Two optical polymeric fluids are used, one having an index of refraction higher than the other. A base portion of the microlens is printed using the lower index of refraction material and a cap portion of the microlens is printed over the base portion to produce a radiused formed microlens. Inter-diffusion of the base portion and top or cap portion creates a generally uniform gradient diffusion zone in the axial (vertical) direction wherein the lower boundary of the zone has the index of the base portion and the upper boundary of the zone has the index of the top portion. After a sufficient gradient diffusion zone is formed, the formed microlens is solidified by curing or other means to stop any further diffusion. The microlenses may be formed as individual lenses on a optical substrate or as an array of microlenses.

Abstract: Barium titanate-based particles having a coating comprising an oxide, hydrous oxide, hydroxide or organic acid salt of a metal other than barium or titanium, wherein at least 90 percent of said particles have a particle size less than 0.9 micrometer when said particles are dispersed by high shear mixing, useful in the fabrication of thin, fine-grained dielectric layers for multilayer ceramic capacitors with high breakdown voltage.

Abstract: The invention relates to a method of producing Pd/Au-containing supported catalysts by CVD (chemical vapor deposition) of vaporizable Pd/Au precursors. For this purpose, suitable noble metal precursors are vaporized and deposited on porous support bodies and subsequently reduced thermally or chemically to the metal and thereby fixed to the support. In particular, the invention relates to the production of Pd/Au coated catalysts on porous supports by this method.

Abstract: The present invention provides a method for manufacturing zeolite which is useful as catalyst carrier for exhaust gas clean up by decomposition, reduction or oxidation catalyst carrier for synthesis and/or decomposition of organic or inorganic chemicals, and membrane for selective separation of organic substances, gases and inorganic cations. This new method is one in which a crystalline silica or amorphous glass contained in a fired ceramic substrate is used as a silica source for forming a natural or synthetic zeolite film on the ceramic substrate, while at the same time making the ceramic substrate porous.

Abstract: A method for adjusting the size of cooling holes (4) of a gas turbine component (1) is disclosed in which the component (1) is shielded with an easy removable and non conduction shielding material (7) without shielding the cooling holes (4) itself. The cooling holes (4) are then coated by means of a galvanic process and thereby a manufacturing tolerance of the size of the cooling holes (4) is reached. The shielding material (7) is removed and, subsequently, a heat treatment for securing a bonding of the metallic coating is applied.

Abstract: The present invention provides a chemical vapor deposition using, as feed gases, a silicon compound and hydrazine or a derivative thereof, or a compound containing both silicon and nitrogen, and a process and a system useful for chemical vapor deposition growth, in which a chlorinated silane compound and ammonia, feed gases, are preliminarily reacted with each other, and the resulting reaction gas mixture from which the ammonium halide produced by the preliminary reaction has been eliminated is fed to form a thin film on a substrate.

Abstract: The methods to create three-dimensional artworks (such as painting, sculpture, calligraphy) comprise heating and melting the polymeric compounds, applying molten polymeric compounds to various substrates (paper, wood, ceramic, metal, marble, plastics, glass, fabric, rubber, stone). Once applied, the molten polymer can be manipulated at artist's discrete while it is still fluid and soft. The heating applicator and heating tools are used to melt and manipulate the polymeric compounds before or after polymeric compounds solidify. The resulting products have a physical three-dimensional sculptured structure.

Abstract: A method of forming a coating of polyionic materials in a layer-by-layer-like manner onto a polymeric material is provided. A polymeric material, such as a contact lens, can be dipped once into a solution of polyionic materials such that layers of polyionic material can be formed thereon. A single dip solution of the present invention typically contains a polyanionic material and a polycationic material in a non-stoichiometric amount and maintained within a certain pH range.

Abstract: In a method of application of a coating medium by use of a spray device onto a moving surface, which in the direct application method is the surface of a material web, specifically a paper or cardboard web, an atmosphere of back-moistening and/or moistening medium for the atomized coating medium is maintained in the area of the spray device.

Abstract: An information layer for an optical information storage medium is formed in a centrifuge. A photopolymerizable composition is applied to a solid base having a relief pattern, and a flexible, transparent film layer is applied on top of the composition. The three are spun in a centrifuge to cause a thin, even distribution of the photopolymerizable composition, which is photopolymerized. The resulting replica is separated from the relief pattern and has a fluorescent material applied thereto. Alternatively, the replica has a non-fluorescent material applied thereto, and the non-fluorescent material is made fluorescent through diffusion. Multiple information layers thus formed can be glued together to form a multilayer optical information storage medium.

Abstract: The present invention is a method of making a thin film of a polyurethane. The method has the steps of: (a) vacuum coating a thin layer of a solventless mixture of a monomer mixture, said monomer mixture selected from the group consisting of polyols, polyisocyanates and combinations thereof, onto a substrate in a vacuum chamber; and (b) curing the monomer as said thin film of said polyurethane.

Abstract: The present invention enables selective plating of a substrate by use of the method of removing or deactivating by an argon laser beam L an electroless plating reaction catalyst imparted to the substrate.