Abstract: A method for the treatment of diabetes mellitus and conditions associated with diabetes mellitus in a mammal, which method comprises administering an effective non-toxic and pharmaceutically acceptable amount of an insulin sensitizer and an insulin secretagogue, to a mammal in need thereof.

Abstract: This invention relates to pharmaceutical compositions and methods for treating alopecia and promoting hair growth using pyrrolidine derivatives.

Abstract: Niacin and niacin prodrugs are topically administered as suitable formulations ro devices for impoving the lipid profiles of subjects, preferably humans.

Abstract: The present invention is a container for an IV aqueous solution of a Gram-positive oxazolidinone agent, such as linezolid a the compound of formula: 1

Abstract: The invention relates to a method for the treatment or prevention of a condition or disease selected from the group consisting of hypertension, (acute and chronic) congestive heart failure, left ventricular dysfunction and hypertrophic cardiomyopathy, myocardial infarction and its sequelae, supraventricular and ventricular arrhythmias, atrial fibrillation or atrial flutter, atherosclerosis, angina (whether stable or ustable), renal insufficiency (diabetic and non-diabetic), heart failure, angina pectoris, diabetessecondary aldosteronism, primary and secondary pulmonary hyperaldosteronism, primary and pulmonary hypertension, renal failure conditions, such as diabetic nephropathy,glomerulonephritis, scleroderma, glomerular sclerosis, proteinuria of primary renal disease, and also renal vascular hypertension, diabetic retinopathy, the management of other vascular disorders, such as migraine, Raynaud's disease, luminal hyperplasia, cognitive dysfunction (such as Alzheimer's), and stroke, comprising administering

Abstract: A novel class of imidazo heterocyclic compounds, pharmaceutical compositions comprising them and use thereof in the treatment and/or prevention of diseases and disorders related to the histamine H3 receptor. More particularly, the compounds are useful for the treatment and/or prevention of diseases and disorders in which an interaction with the histamine H3 receptor is beneficial.

Abstract: A method of treating onychomycosis is described which includes administration to an infected area around a nail of a patient a tissue softening composition containing urea and an antifungal composition in one or separate compositions, concurrently or non-concurrently. Also described is a kit which contains the unit dosage forms, a protective gel and appropriate dressings for ready application.

Abstract: The subject invention provides novel compositions of biologically active discodermolide compounds which can advantageously be used for immunomodulation and/or treating cancer. The compounds of the subject invention have utility for use in the treatment of cancer, as tubulin polymerizers and as microtubule stabilization agents. The present invention also pertains to the identification of regions of the discodermolide molecule which are responsible for certain aspects of the bioactivity of discodermolide compounds.

Abstract: Methods are described for preventing or reducing the risk of a first occurrence of a cardiovascular event using an HMG-CoA reductase inhibitor alone or in combination with another lipid altering agent. Subjects to be treated are those having an average serum total cholesterol level, an average to mildly elevated serum low-density lipoprotein cholesterol level, and a below average serum high-density lipoprotein cholesterol level, with no history of clinically evident coronary disease.

Abstract: Arthropod-controlling composition comprising an &agr;-pyrone compound shown by the formula: 1

Abstract: The present invention provides a method of preventing pest feed harm on a fibrous product, a composition preventing pest feed harm on a fibrous product and uses of 1-methyl-2-nitro-3-[(3-tetrahydrofuryl)methyl]guanidine for preventing pest feed harm on a fibrous product. The method comprises applying to a fibrous product, an effective amount of 1-methyl-2-nitro-3-[(3-tetrahydrofuryl)methyl]guanidine. The composition comprises a carrier and as an active ingredient 1-methyl-2-nitro-3-[(3-tetrahydrofuryl)methyl]guanidine.

Abstract: A dosage form for intranasal and/or inhalation administration of an analgesic having low opioid receptor binding activity to a warm blooded animal, that includes a pharmaceutically effective amount of the analgesic. A preferred analgesic is tramadol, a tramadol and/or a pharmaceutically acceptable salt, metabolite or derivative thereof. Methods of making and using the formulation according to the invention are also provided.

Abstract: The production of IgA is selectively inhibited by orally administering 15-deoxyspergualin or pharmacologically acceptable salts thereof, thus preventing and treating IgA-associated immunological diseases such as IgA nephropathy.

Abstract: Identification of MYC target genes whose expression is either induced or repressed by c-myc induction in human fibroblasts is disclosed. Also disclosed are methods of inducing or repressing expression of MYC target genes.

Abstract: A method for the treatment of disorders relating to serotonergic system in humans, for example depression and anxiety, comprising orally administering deramciclane in a daily dosage of about 20 to about 60 mg.

Abstract: A method for treating malignant cells such as leukemia or chronic myeloid leukemia, in a mammal, comprising of administering to the mammal a leukemia therapeutically effective amount of reactive oxygen intermediates. A method of treating cancer in a mammal with cancer and modulating the mammal's immune system, comprising of administering to the mammal in need thereof a cancer therapeutically effective amount of reactive oxygen intermediates. A method of treating leukemia in a mammal with leukemia, comprising of administering to the mammal in need thereof a leukemia therapeutically effective amount of ozone into the mammal's blood and a leukemia therapeutically effective amount of ether lipids.

Abstract: The present invention relates to use of a composition for symptomatic relief, when needed, comprising, in admixture

Abstract: A continuous output system makes paper coating by combining an emulsifier with ASA particles having a mean average size in the low to sub-micron region. A turbine, pump, blender or other device exposes the ASA to a number of repeated episodes of high shear until the resulting ASA is in the form of particles having a mean average diameter in approximately the 1&mgr; range. The measure of the amount of high shear is identified by an energy factor index. A system for cooling the ASA enables the processing without causing a hydrolyzing of the ASA, even when a heated cooked emulsion is used.

Abstract: A catalytic composition for the dimerization, the codimerization or the oligomerization of olefins results from the dissolution of at least one nickel complex that contains a heterocyclic carbene in a liquid mixture that comprises at least one ammonium halide or quaternary phosphonium halide, at least one aluminum halide and optionally at least one organometallic aluminum compound. It is used in a process of dimerization, codimerization or oligomerization of olefins.

Abstract: Small cross-section composites are used as reinforcements for concrete. The composites include longitudinally oriented fibers embedded in a depolymerizable and repolymerizable thermoplastic matrix. The composites are mixed into the wet concrete and poured with the concrete to form a reinforced concrete structure.

Abstract: A method of making improved optical quality polymers by normalizing the polymerization rates of the components of the monomer mix used is presented. The polymers produced by this process minimize the formation of separate domains and decrease the level of grit in contact lenses made from the polymers. Monomer reaction rates can be normalized by conducting the polymerization at elevated temperature.

Abstract: The present invention discloses a method for enhancing the wear-resistance of polymers by crosslinking them, especially before irradiation sterilization. In particular, this invention presents the use of chemically crosslinked ultrahigh molecular weight polyethylene in in vivo implants.

Abstract: A drag reduction mixture made from a 30-70 proportion of polyisobutylene particles and water. The mixture further contains a surfactant, a viscosifier, an anti-foaming agent, and a biocide. The mixture can be made as a slurry or suspension, depending on the amount of viscosifier.

Abstract: For well kill treatment to prevent the intrusion of formation fluids into the wellbore while the well is open, a well kill additive including a dry mixture of water soluble crosslinkable polymer, a crosslinking agent, and a reinforcing material of fibers and/or comminuted plant materials. The method of forming a well kill fluid includes contacting the additive with water or an aqueous solution, with a method of conforming the formation further including the step of injecting the fluid into the wellbore.

Abstract: A synthetic aggregate having a multiplicity of uses such as for mixing with a cementing material to form concrete, mortar or plaster is disclosed. The aggregate includes crushed fragments of a size which are capable of passing through mesh screen having sieve openings ranging from between about 19 mm and 75 microns. The aggregate fragments are made by curing and then crushing a compressed product. The compressed product is made by compressing an aqueous cementitious mixture comprising cement and at least one member selected from the group consisting of bottom ash and non-cementitious fly ash. The compressed product is cured so that it has a compressive strength of at least 600 psi.

Abstract: A stain/topcoat system for non-porous thermoset and/or thermoplastic articles comprises a pigmented stain, and a topcoat comprising one or more non-siloxane film-forming polymers, an emulsion of one or more curable organopolysiloxanes, a weatherability agent having a functional group that is reactive with carboxylate functional sites and water. The topcoat displays exceptional adhesion and weatherability to pigmented stained surfaces.

Abstract: The present invention provides a wood additive thermoset composite (WATC) to mold a three dimensional product, such as a speaker cabinet, which combines the favorable qualities of both wood and thermosetting resin/plastic. In particular, the WATC has at least about 50% wood by weight with the rest substantially being thermosetting resin material by weight.

Abstract: A flame-retarded resin composition contains: (A) an ABS resin; (B) an aromatic phosphate having a melting point of 80° C.

Abstract: The invention relates to compositions useful for bonding fluoropolymer to substantially non-fluorinated polymer. The compositions of the invention comprise a substantially non-fluorinated polymer or a mixture of said polymers, a di- or polyamine, preferably, an aliphatic diamine, and an onium catalyst, preferably, a phosphonium salt.

Abstract: The water base adhesion promotor for polypropylene comprises:

Abstract: A method of achieving a novel superior dispersion of insoluble sulfur comprises mixing polysulfur while it is in the rubbery state with a diluent, such as rubber, to obtain a novel uniform dispersion of the sulfur in the diluent.

Abstract: This invention relates to a technique for making a high quality natural rubber composition having a dirt content of less than 0.03 percent and a constant Mooney viscosity of 60 by blending up to 60 weight percent cup-lump rubber with natural rubber made by coagulating natural rubber latex.

Abstract: A raw material for injection molding comprising a metal powder or a ceramic powder, and a binder containing at least two types of resins, obtained by coating or encapsulating the metal powder or ceramic powder particles with a resin insoluble in a predetermined solvent and having a high softening temperature, and subsequently kneading the resultant powder and a resin soluble in the solvent and having a low softening temperature.

Abstract: The present invention provides a novel organic/inorganic hybrid hydrogel which is superior in homogeneity, transparency, mechanical properties, and in swelling and shrinking properties, a manufacturing method therefore, and a dry body of the organic/inorganic hybrid hydrogel which is obtained by removing water from said hydrogel. The organic/inorganic hybrid hydrogel comprises a water soluble polymer (A), a water swelling clay mineral (B) which can be homogeneously dispersed in water, and water (C), and water (C) is included in a three-dimensional network formed by (A) and (B).

Abstract: The invention relates to self-adhesive addition-crosslinking silicone compositions which contain the components

Abstract: A polyoxymethylene resin composition, having enhanced tensile elongation, thermal stability, processibility and impact resistance, comprises: (i) from 45 to less than 97% % by weight of a polyoxymethylene resin (Component A); (ii) from 1 to less than 20% by weight of a thermoplastic polyester elastomer (Component B); (iii) from 2 to 35% by weight of a thermoplastic polyurethane elastomer (Component C); and (iv) from 0.1 to less than 10% by weight of a maleic anhydride-grafted aliphatic polyolefinic rubbery polymer (Component D), based on the total weight of Components A, B, C and D.

Abstract: The present invention discloses polymeric compositions containing a vinylaromatic lubricating copolymer which can be melt processed to provide plastic films or layers having excellent optical, printing, weathering, and tensile impact resistance characteristics. The present invention also discloses a processes for preparing plastic films of the compositions of the present invention. The present invention also discloses composite articles having the plastic films of the present invention and an underlying substrate.

Abstract: A blend of one or more crosslinked polymers or copolymers prepared from an olefinically unsaturated polymerizable carboxylic or anhydride monomer and at least one high molecular weight essentially linear polymer prepared from an olefinically unsaturated polymerizable carboxylic acid monomer. The blend is neutralized to typically a low pH, and generally contains a noncovalent, e.g. ionic, crosslinking agent, and a cure rate modifier. The hydrogel blend is capable of containing a large amount of water, has good tack, good adhesion, and can be utilized as an application vehicle having a backing thereon as well as containing various substances such as personal care compounds, pharmaceuticals, active ingredients, and the like.

Abstract: The melt of polyvinyl aromatic polymers comprising from 10 to 45 weight % of star branched polymer prepared using a combination of thermal and tetra functional peroxide initiation has an improved melt strength permitting better foam formation for extrusion foam blown with conventional blowing agents and inert gases including CO2 and an improved tensile strength for oriented polystyrene (OPS) articles, e.g. blown film or extruded sheet.

Abstract: Linear, branched or crosslinked polymer based on at least one monomer, possessing a free, partially salified or completely salified strong acid functional group, copolymerized with at least one monomer chosen either from esters of aliphatic alcohols comprising from 8 to 30 carbon atoms and of unsaturated monocarboxylic acids or from esters of aliphatic alcohols comprising from 8 to 30 carbon atoms and of unsaturated polycarboxylic acids. Preparation process, use as thickener and/or emulsifier and composition comprising it.

Abstract: The present invention relates to novel hydrocarbon resins and the process for preparing them. In particular, the invention relates to the production of hydrocarbon/acrylic hybrid resins which are suitable for use in formulating adhesives, printing inks, and other coating compositions.

Abstract: The present invention modifies a cross-linkable thermoset polymer with a thermoplastic polymer to create a spinnable thermoset/thermoplastic polymer composition that may be spun into thermoset/thermoplastic fibers.

Abstract: The invention provides urethane polymers bonded to therapeutically active compounds, such as antibiotics. The invention also features methods of applying therapeutically active compounds to polyurethane polymers using textile dyeing. These polymers may be used in a variety of clinical applications.

Abstract: There is provided a bulk handling method for maintaining granular material in a free-flowing state in a vessel during storing, transporting, or while in an idle mode in a fluidized-bed reactor or purger.

Abstract: A universal masterbatch composition for adding fillers and particularly pigment to polymers, having up to 85%, by weight, of at least one filler, up to 25%, by weight, of at least one viscosity modifier and a remainder quantity of a styrene butadiene block copolymer.

Abstract: This invention relates to high melting polyolefin copolymers suitable as thermoplastic elastomers and catalysts and methods for their synthesis. These elastomeric olefin copolymers are characterized by a mole fraction of crystallizable component Xc from about 30 to about 99%; low glass transition temperatures, below −20° C., and typically below −50 ° C.; melting points above about 90° C.; high molecular weights; a molecular weight distribution MW/Mn</=10; and a narrow composition distribution between chains of </=15%. The novel copolymers of the invention range from reactor blends to multiblock copolymers that can be sequentially fractionated into fractions of differing crystallinities, which fractions nevertheless show compositions of comonomers which differ by less than 15% from the parent polymer (reactor product).

Abstract: Hyperbranched copolymers comprising at least one C2-C20 &agr;-monoolefin monomers and 0.2 to 20 mole % of at least one &agr;,&ohgr;-non-conjugated diene monomers having 5 to 18 carbon atoms are prepared by coordination (metallocene) copolymerization of the monomers and quenching the reaction prior to the formation of a gelled product. The products are characterized by a number average molecular weight less than 5 times the entanglement molecular weight of a homopolymer prepared using the same catalyst but in the absence of the diene component.

Abstract: A silicone sealant composition containing: (a) a moisture curable organopolysiloxane component, comprising a mixture or reaction product of (i) an organopolysiloxane polymer having hydrolyzable substituent groups and (ii) a polyfunctional silicon compound having two or more hydrolyzable substituent groups, (b) a filler and (c) a hydrocarbon fluid comprising, based on 100 parts by weight of the hydrocarbon fluid, greater than 40 parts by weight cyclic paraffinic hydrocarbons and less than 60 parts by weight noncyclic paraffinic hydrocarbons, exhibits improved tensile, elongation and adhesive properties.

Abstract: A method for producing a basic amino acid-modified organopolysiloxane comprising reacting (A) a basic amino acid with (B) an organopolysiloxane having carboxylic anhydride groups bonded to silicon atoms.

Abstract: The present invention provides a polymer that can be used as an anti-refelctive coating (ARC) polymer, an ARC composition comprising the same, methods for producing the same, and methods for using the same. The polymer of the present invention is particularly useful in a submicrolithographic process, for example, using KrF (248 nm), ArF (193 nm), or F2 (157 nm) laser as a light source. The polymer of the present invention comprises a chromophore that is capable of absorbing light at the wavelengths used in a submicrolithographic process. Thus, the ARC of the present invention significantly reduces or prevents back reflection of light and the problem of the CD alteration caused by the diffracted and/or reflected light. The ARC of the present invention also significantly reduces or eliminates the standing wave effect and reflective notching.