Abstract: 1-Oxo- and 1,3-dioxo-2-(2,6-dioxopiperidin-3-yl)isoindolines substituted in the 4- and/or 7-position of the isoindoline ring and optionally further substituted in the 3-position of the 2,6-dioxopiperidine ring reduce the levels of inflammatory cytokines such as TNF&agr; in a mammal.

Abstract: The present invention relates to a process for preparing piperidine derivative compounds of the formulae: 1

Abstract: The present invention relates to a procedure for the oxidation of a thioether group to a sulfoxide group, with aqueous sodium percarbonate in the presence of a molybdenum salt as a catalyst. The procedure is of application to oxidize the thioether group of a compound (I), where R1 is a C1-C6 alkyl, a halogenated C1-C6 alkyl, or —(CH2)n—OR9, where n is an integer between 1 and 6 and R9 is H or a C1-C6 alkyl; R2, R3, R4, R5, R6 and R8, independently form each other represent H, a C1-C6 alkyl, or C1-C6 alkoxy; and R7 is H, a C1-C6 alkyl, a C1-C6 alkoxy or a C1-C6 fluorinated alkoxy, in order to obtain the sulfinyl derivative (II).

Abstract: The invitation provides an efficient method for the resolution of (R)-(+)-(formula (I)) and (S)-(−)(formula (II))-enantiomers of amlodipine, where the chiral reagent for resolution is tartaric acid and the chiral auxiliary reagent for resolution is deuterated dimethyl sulphoxide (DMSO-d6).

Abstract: The present invention aims at providing a process for producing a substituted alkylamine derivative useful as an intermediate for medicine or agrochemical, from a 2-aminothiophenol derivative at a high yield industrially.

Abstract: The present invention describes a process for preparing isoxazoles of the formula I 1

Abstract: Novel pyrazoles of formula (I) wherein R1 represents halogen, C1-6 alkyl, C1-5 haloalkyl, C2-6 alkoxy, C1-4 alkylthio, C2-5 alkenyloxy, C3-5 alkynyloxy, C2-6 (total carbon number) alkoxyalkyl, C2-6 (total carbon number) alkylthioalkyl, C1-5 haloalkoxy, C2-6 (total carbon number) alkoxyalkoxy, hydroxy or optionally substituted phenyl, R2 represents hydrogen, halogen, C1-5 alkyl, C2-6 (total carbon number) alkoxyalkyl, C2-6 (total carbon number) alkylthioalkyl, C2-6 (total carbon number) alkylsulfinylalkyl, C2-6 (total carbon number) alkylsulfonylalkyl or C1-5 haloalkyl, R3 represents hydrogen, C1-5 alkyl, —COR4, COOR5, CH(OR6)2 or CH2(Si(R7)3, R4 represents C1-10 alkyl, C1-6 haloalkyl, C2-6 alkenyl, optionally substituted C3-6 cycloalkyl, C2-6 (total carbon number) alkoxyalkyl, C2-6 (total carbon number) alkylthioalkyl, optionally substituted phenyl, C1-6 haloalkyl, alkylamino, di-(C1-6 alkyl)amino or optionally substituted phenylamino, R5 represents C1-7 alkyl, R6 and R7 represent C1-6 alkyl, and n is 1

Abstract: A process for preparing N-alkenyl-amides by reacting the corresponding NH-amides with acetylenes in the liquid phase in the presence of basic alkali metal compounds and of a cocatalyst comprises using as the cocatalyst compounds of the general formulae (Ia) and/or (Ib)

Abstract: The invention relates to a method for producing compounds of general formula (I) wherein R1 is selected from the following groups: (a) OR5 and (b) mono-, di-, or tri-substituted phenyl; and R2 represents a group (C1-C6) alkyl. The method is characterized in that it comprises the following steps: a) reacting a compound of general formula (II) with an acid of general formula R1CH2 COOH (III) in a water-free medium; b) reacting the resulting compound with a strong base in an aprotic solvent in order to obtain an intermediate cyclic compound which forms a compound of general formula (I) after dehydration; and c) isolating said resulting compound of general formula (I).

Abstract: In this application is disclosed a process for producing 3,9-bis(2-chloroethyl)-2,4,8,10-tetraoxaspiro[5.5]undecane comprising a step of reacting acrolein, pentaerythritol, and hydrogen chloride at one step, according to which the compound can be obtained conveniently in high yields.

Abstract: Please add the following abstract: Seco-baccatin III derivatives of formula: 1

Abstract: 1-Deoxybaccatin III, 1-deoxytaxol and 1-deoxy taxol analogs and method for the preparation thereof.

Abstract: The present invention relates to a process for producing epoxides. This process comprises the oxidation of hydrocarbons in the presence of oxygen and at least one reducing agent and a catalyst, characterized in that the reaction mixture is passed through at least one catalyst-containing layer and through at least one adsorbent-containing layer, which adsorbs the epoxide. The catalyst-containing layers and the adsorbent-containing layers are arranged alternately one behind the other such that the reaction mixtures passes through a catalyst-containing layer, and an adsorbent-containing layer.

Abstract: It is known to polymerize olefins using transition metal complexes and/or compounds. There is an ongoing search for catalysts for olefin polymerization which do not rely on transition metals as the active center. The present invention provides novel aluminum phosphinimine complexes, containing additional heteroatoms which are useful in the polymerization of olefins.

Abstract: This invention relates to the novel use of diphenyl phosphonates in the treatment of disease states mediated by the chemokine, Interleukin-8 (IL-8).

Abstract: Diaryl carbonates such as diphenyl carbonate is obtained in high yields and purity by melt crystallization from solutions of the crude product. Multi-stage crystallizations and controlled heating of the crystals purify the product.

Abstract: A method for separating at least one lower polarity fluid from a mixture of fluids having varying polarity, comprising contacting at least one low polarity or non-polar polymeric membrane with the mixture of fluids under conditions such that the at least one lower polarity fluid selectively permeates through the membrane, wherein the membrane is one which has a ratio of heteroatoms chemically bonded to the carbon atoms in the membrane to the number of carbon atoms of less than about 0.2, preferably less than about 0.05.

Abstract: A process for preparing chlorocarbonyl chlorides of the formula (I) 1

Abstract: A process for the preparation of chlorocarboxylic chlorides of formula (I) 1

Abstract: Esters derived from fatty acids and juvenoid alcohols of the general formula (I), in which X means the oxygen atom or the NH group, Y means the NH group or the oxygen atom, R means methyl, ethyl, 1-propyl, 2-methylethyl or propargyl and R′ means saturated or unsaturated alkyl with 4 to 22 carbon atoms. Esters derived from fatty acids and juvenoid alcohols are produced by a reaction of a juvenoid alcohol of the general formula (II), in which X means the oxygen atom or the NH group, Y means the NH group or the oxygen atom and R means methyl, ethyl, 1-propyl, 2-methylethyl or propargy] with a fatty acid chloride of the general formula (Ill): R′COC1 in which R′ means saturated or unsaturated alkyl with 4 to 22 carbon atoms, under the continuous stirring, at 0 to 70° C., using a convenient solvent, as toluene, xylene or benzene and under the presence of a base catalyst, as triethylamine, pyridine or quinoline.

Abstract: A compound is of formula (I), in which: A1 to A4, E1 and E2 each independently represent hydrogen or an optionally-substituted hydrocarbon group; B1 and B2 each independently represent a single bond, an oxygen atom or an optionally-substituted hydrocarbon group; MG1 and MG2 each independently represent an optionally-substituted ring system; CG is a divalent or polyvalent chiral group. The optically active compound may be used as a doping agent for liquid crystals for a wide range of applications including solid state cholesteric filters for projection displays, circular polarisers, optical filters, etc.

Abstract: A method for production of pivalic acid comprising the steps of: (a) reacting isobutylene, carbon monoxide, and a first catalyst to produce a reaction mixture; (b) contacting the reaction mixture with water, thereby producing a crude acid product having pivalic acid and oligomeric neo-carboxylic acid; (c) separating the pivalic acid and the oligomeric neo-carboxylic acid from the crude acid product; (d) reacting the oligomeric neo-carboxylic acid with a source of carbon monoxide at a temperature of less than 200° C. in the presence of a second catalyst to produce a C5 carbocation product, wherein the first and second catalyst are either the same or different; and (e) reacting the C5 carbocation product with water; thereby producing pivalic acid having an overall yield of at least 80 wt. %.

Abstract: An aminopolycarboxylate is described, which is represented by the following formula (1): 1

Abstract: A method for the decomposition of a Michael type adduct, characterized by causing a Michael type adduct to react in the presence of an N-oxyl compound thereby decomposing the Michael type adduct into acrylic acid and/or the acrylic ester and/or the alcohol and a method for the production of acrylic acid and/or the acrylic ester, characterized by comprising a step of recovering a Michael type adduct formed in the process for the production of acrylic acid or acrylic ester and a step of decomposing the recovered Michael type adduct by the method of decomposition mentioned above. This invention, therefore, allows promotion of efficient utilization of the raw materials.

Abstract: This invention concerns a method for absorbing acrylic acid, characterized by supplying an acrylic acid-containing reaction gas component obtained by the reaction of catalytic gas phase oxidation to an acrylic acid absorption column and advancing a high boiling inert hydrophobic organic liquid into counter-flow contact with said reaction gas in said acrylic acid absorption column with the mass flow rate of the organic liquid fixed in the range of 0.2-7.0 times the mass flow rate of the acrylic acid in the reaction gas thereby absorbing acrylic acid in said organic liquid and obtaining an acrylic acid-containing solution including a low boiling substance in the range of 0.7-7.5 wt % based on the weight of bottom liquid of absorption column.

Abstract: A process for preparing amines comprises reacting an epoxide of the formula (I) 1

Abstract: Processes for the stereospecific synthesis of coenzyme Q10, ubiquinone, are disclosed; a total synthetic procedure using geraniol as the starting material. The process of the invention results in high yields of isometrically pure ubiquinone. The synthetic coenzyme Q 10 can be used as an antioxidant, a nutritional supplement and as a pharmaceutical in treating many conditions.

Abstract: The present invention is a high-quality bisphenol A wherein the content of sodium is not more than 80 ppb and the content of each element of the group A consisting of iron, nickel, chromium, manganese, lead, and molybdenum is not more than 50 ppb, or a high-quality bisphenol A containing an organic compound such as 9,9′-dimethylxanthene, 2-(4-hydroxyphenyl)-2,4,4-trimethylchroman, 2,2,4-trimethyl-chromene, etc., in an amount of lower than a specific amount, and a preparation process of these high-quality bisphenol A. When an aromatic polycarbonate is prepared using the high-quality bisphenol of the invention, an aromatic polycarbonate which is not colored at the preparation thereof and molding the polycarbonate.

Abstract: Dinitrotoluene (DNT) is produced by the adiabatic nitration of toluene with nitric acid at a temperature of from about 60 to about 200° C. and at a molar ratio of toluene to nitric acid of from about 1:1.5 to about 1:3.0. The reaction mixture thus-obtained is concentrated to a water content of up to 30% by weight. The dinitrotoluene which is present in the reaction mixture is at least partially (if not completely) removed from the reaction mixture either before or after concentration of the reaction mixture. The DNT which is still present in the vapor generated during the concentration of the reaction mixture is kept liquid by the addition of a solvent to the vapors generated during concentration of the reaction mixture. The solvent added to vapor, together with any DNT present in the vapor is recovered. This solvent/DNT mixture may be recycled directly to the reaction vessel. The solvent/DNT mixture may also be separated. The separated solvent may be recycled to the solvent addition step.

Abstract: Methods and materials are provided for the production and purification of halogenated compounds and intermediates in the production of 1,1,1,3,3-pentafluoropropane. In a preferred embodiment, the process steps include: (1) reacting carbon tetrachloride with vinyl chloride to produce 1,1,1,3,3-pentachloropropane; (2) dehydrochlorinating the 1,1,1,3,3-pentachloropropane with a Lewis acid catalyst to produce 1,1,3,3-tetrachloropropene; (3) fluorinating the 1,1,3,3-tetrachloropropene to produce 1-chloro-3,3,3-trifluoropropene; (4) fluorinating the 1-chloro-3,3,3-trifluoropropene to produce a product mixture containing 1,1,1,3,3-pentafluoropropane; and (5) separating 1,1,1,3,3-pentafluoropropane from by-products.

Abstract: Tuning fuel composition delivered to a spark ignition, internal combustion engine as a function of driving cycle conditions results in improvements in one or more of fuel efficiency and combustion emissions.

Abstract: An integrated process of preparing a C2-5 alkenyl-substituted aromatic compound using a C6-12 aromatic compound and a C2-5 alkane as raw materials.

Abstract: The present invention provides a process for producing an alkylaromatic compound comprising the step of contacting an alkylatable aromatic compound with an alkylating agent under alkylation conditions in the presence of a alkylation catalyst comprising phosphorus and a porous crystalline inorganic oxide material having an X-ray diffraction pattern including the d-spacing maxima at 12.4±0.25, 6.9±0.15, 3.57±0.07 and 3.42±0.07 Angstrom.

Abstract: A process for the disproportionation of cumene is disclosed which comprises the step of contacting a feed containing cumene, under disproportionation conditions, with a catalyst comprising a molecular sieve, preferably TEA-mordenite. The contacting step disproportionates at least part of the cumene in the feed to provide a disproportionation effluent containing benzene and a mixture of diisopropylbenzene isomers. The effluent is then recovered and contains, prior to any separation step, less 1% of ortho-diisopropylbenzene by weight of the total diisopropylbenzene content of said effluent, less than 1 wt % of n-propylbenzene, less than 5 wt % of triisopropylbenzenes and less than 5 wt % of disproportionation products other than benzene and diisopropylbenzenes.

Abstract: Disclosed is a method of rejuvenating a molecular sieve. The method includes contacting a molecular sieve having a methanol uptake of less than 1, or a catalyst containing molecular sieve having a methanol up of less than 1, with anhydrous liquid or vapor until the methanol uptake ratio is increased by at least 10%. The rejuvenated molecular sieve or catalyst can be used to make an olefin product from an oxygenate-containing feedstock. The preferred molecular sieve is a silicoaluminophosphate (SAPO) molecular sieve.

Abstract: An olefin metathesis catalyst consists essentially of a transition metal or oxide thereof supported on a high purity silica support possessing low amounts of acidic or basic sites such that in the reaction of pure butene-1 over said catalyst under metathesis reaction conditions the reaction possesses a weight selectivity to hexene-3 of at least 55 wt %.

Abstract: A method for concentrating 2,6-dimethylnaphthalene in a dimethylnaphthalene isomer mixture includes supplying the dimethylnaphthalene isomer mixture to an adsorption column packed with Y-type zeolite. In this instance, by setting the value derived from the expression (u⅓/&egr;)d−5/3 at 14 (m5/3 s−⅓kg−1) or more, the concentration ratio of 2,6-dimethylnaphthalene to 2,7-dimethylnaphthalene can be 2.0 or more. u here represents the linear velocity (m/s) of the dimethylnaphthalene isomer mixture supplied to an adsorption column, &egr; represents the packing density (kg/m3) of Y-type zeolite, and d represents the grain size (m) of the Y-type zeolite.

Abstract: A container body of a concrete cask includes a storage portion that stores a canister. A refilling system includes a reduction cylinder having an outside diameter smaller than the diameter of the storage portion and an inside diameter larger than the diameter of the canister, a first lift mechanism configured to raise and lower the reduction cylinder between a down position in the storage portion and an up position wherein it is drawn out of the storage portion, and a second lift mechanism having a holding portion for holding one end portion of the canister and configured to raise and lower the canister with respect to the container body. In refilling operations, the canister is loaded into and unloaded from the storage portion of the container body by the second lift mechanism with the reduction cylinder set in the storage portion.

Abstract: A photochemical process for removing or minimizing the concentration of PCDD or PCDF compounds within an industrial gas stream. The process includes the direct photolysis of PCDD or PCDF compounds. Light within a particular spectral range is irradiated into the gas stream and is absorbed by the PCDD and PCDF compounds in the presence of a hydrogen donor and this results in producing a lower chlorinated PCDD or PCDF compound form. In addition, the gas stream may be treated by removing particular matter therefrom and thereafter subjected to the above-described irradiation. Further, as another optional step, the gas stream may be irradiated with the specific purpose of targeting PCDD and PCDF precursor compounds. In this case, the irradiation is absorbed the precursor compounds causing them to be chemically modified to different chemical compounds that do not participate in chemical reactions that result in the formation of PCDD and PCDF compounds.

Abstract: A semi-automatic needle loader assembly is disclosed that includes a setting group for positioning at least one of an isotope seed and a spacer, a loading group operatively engaging the setting group for depositing the at least one of an isotope seed and a spacer, a viewing member for visualizing the at least one of an isotope seed and a spacer, and a needle holding group positioned to pass the at least one of an isotope seed and a spacer to a needle assembly.

Abstract: An apparatus is described that efficiently resupplies radioactive seeds to a brachytherapy applicator. A seed-holding system includes a holder and a transfer device. The holder, which may be disposable, stores the radioactive seeds and the transfer device, which may be reusable, helps shield and dispense the seeds. The holder is coupled to the transfer device, and the apparatus is mated to an applicator. After seeds have been dispensed, the apparatus may be disconnected from the applicator and the empty holder may be ejected from the transfer device, and replaced with a full holder.

Abstract: A device and method for stimulating a beneficial blood circulation especially on the scalp area to prevent, stop and control hair loss, regenerate hair, as well as alleviate pain by means of strategically-placed magnetic bodies incorporated in a portable, grippable model of known geometric structures for generating a healing force of form energy. The magnetic bodies in form of permanent magnets generate an amplified and varying magnetic force in response to the modifying action of the form energy called shape wave. One or more permanent magnets are attached about the body of the grippable device secured by attachment means; at least one permanent magnet is located at the base portion, and another permanent magnet may be located around the wall portions or in designated places within and or outside the grippable device.

Abstract: A method for beneficially restructuring ingestible substances such as sports drinks, water, neutraceuticals, pharmaceuticals, and the like and its contents for consumption by organisms. The method is also applied to topical substances such as lotions and creams. The method involves subjecting such substances for a period of time to an electromagnetic field of a specified flux density varying from 10−5 to 10−21 gauss and a specific frequency varying from 0 hertz to 300 hertz, depending on the intended subsequent use of the substance. The specific flux density and the specific frequency is empirically determined to restructure the substances such that the substances beneficially affect the organism which has the substances incorporated into the organism's metabolism.

Abstract: Disclosed are compositions comprising magnetic nanoparticles, a biocompatible coating, and a target-specific ligand. Also disclosed are devices for treating diseased tissue for use with such compositions. Further disclosed are methods for treating diseased tissue, such as cancer, using such compositions and devices, as well as methods for treating diseased tissue utilizing hypertermia.

Abstract: A system for treating neurological conditions by low-frequency time varying electrical stimulation includes an electrical device for applying such low-frequency energy, in a range below approximately 10 Hz, to the patient's brain tissue. An implantable embodiment applies direct electrical stimulation to electrodes implanted in or on the patient's brain, while a non-invasive embodiment causes a magnetic field to induce electrical currents in the patient's brain.

Abstract: To provide an artificial cardiopulmonary circuit system having high heat resistance and excellent blood compatibility. The artificial cardiopulmonary circuit system includes a hollow fiber membrane oxygenator including a plurality of porous hollow fiber membranes for gas exchange having a blood contact part that contacts blood on one side thereof and a gas contact part that contacts a gas on the other side thereof, and a housing that contains the hollow fiber membranes therein. At least a portion of the blood contact part of the hollow fiber membrane oxygenator is coated with a polymer comprising a repeating unit represented by the following general formula (1) as a main structural component and having a viscosity at 65° C.

Abstract: A system and method for assessing urinary function is provided. The system includes a processor, a tubing assembly forming a first fluid conduit between a first fluid inlet and a first fluid outlet, and an insert member having a channel therethrough and coupled to the first fluid outlet so that fluid flowing through the first fluid conduit may flow through the insert member. The insert member is dimensioned for at least partial insertion into a patient's urethral canal distal of the patient's urethral sphincter, and dimensioned so that, when inserted, it substantially blocks fluid flow into or out of the urethral canal other than through the insert member channel.

Abstract: A method is provided for assessing urinary function including removably coupling a first test module to a portable control device, selecting from a plurality of different tests a first test to assess urinary function, the selection being made based on first module identification information obtained by the control device from the test module, and performing the first test. The method may also include one or more of the steps of inserting an insert member coupled to the first test module at least partially into a patient's urinary tract, infusing fluid through the insert member into the urinary tract, and measuring pressure within the urinary tract as fluid is infused therein.

Abstract: This invention provides an artificial sphincter including a component coated on at least one contacting surface with a polymeric material, the polymeric coating adapted to expand and return to an original configuration and to prevent or inhibit wear or abrasion of the contacting surface. The polymeric material is parylene in some embodiments. The component adapted for inflation and deflation may be a cuff formed from silicon and adapted to surround a urethra or a rectum. Also provided by the present invention is a method of depositing a coating to a surface of an inflatable component by providing a vacuum chamber system having an inner chamber positioned within an outer chamber. At least one coating material is introduced into at least one of the inner and outer chambers to deposit a coating onto an exposed surface of the component. This invention also provides methods of masking portions of surfaces of an inflatable component to prevent a coating from being deposited on the masked portion.

Abstract: A jacket of biological compatible material has an internal volume dimensioned for an apex of the heart to be inserted into the volume and for the jacket to be slipped over the heart. The jacket has a longitudinal dimension between upper and lower ends sufficient for the jacket to surround a lower portion of the heart with the jacket surrounding a valvular annulus of the heart and further surrounding the lower portion to cover at least the ventricular lower extremities of the heart. The jacket is adapted to be secured to the heart with the jacket surrounding at least the valvular annulus and the ventricular lower extremities. The jacket is adjustable on the heart to snugly conform to an external geometry of the heart and assume a maximum adjusted volume for the jacket to constrain circumferential expansion of the heart beyond the maximum adjusted volume during diastole and to permit unimpeded contraction of the heart during systole.